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Original Article Subunit-Specific Developmental Roles of PI3K in SF1- Expressing Cells
My Khanh Q. Huynh1,2orcid , Sang Hee Lyoo1,3orcid , Dong Joo Yang1, Yun-Hee Choi1orcid , Ki Woo Kim1,3orcid

DOI: https://doi.org/10.3803/EnM.2024.1999 [Epub ahead of print]
Published online: August 30, 2024
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1Division of Physiology, Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Korea
2Department of Global Medical Science, Yonsei University Wonju College of Medicine, Wonju, Korea
3Department of Applied Life Science, BK21 FOUR, Yonsei University College of Dentistry, Seoul, Korea
Corresponding author:  Yun-Hee Choi, Tel: +82-2-2228-3052, Fax: +82-2-2228-3052, 
Email: yhchoi1975@yuhs.ac
Ki Woo Kim, Tel: +82-2-2228-3052, Fax: +82-2-2228-3052, 
Email: kiwoo-kim@yuhs.ac
Received: 4 April 2024   • Revised: 27 May 2024   • Accepted: 19 June 2024
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Abstract

Background
Phosphatidylinositol 3-kinase (PI3K) regulates cellular development and energy homeostasis. However, the roles of its subunits in organ development remain largely unknown.
Methods
We explored the roles of PI3K catalytic subunits in steroidogenic factor 1 (SF1)-expressing cells through knockout (KO) of the p110α and p110β subunits.
Results
We examined mice with a double KO of p110α and p110β in SF1-expressing cells (p110αβ KOSF1). Although these animals exhibited no significant changes in the development of the ventromedial hypothalamus, we noted pronounced hypotrophy in the adrenal cortex, testis, and ovary. Additionally, corticosterone and aldosterone levels were significantly reduced. The absence of these subunits also resulted in decreased body weight and survival rate, along with impaired glucose homeostasis, in p110αβ KOSF1 mice.
Conclusion
The data demonstrate the specific roles of PI3K catalytic subunits in the development and function of SF1-expressing organs.

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