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Review Article Parathyroid Gland Generation from Pluripotent Stem Cells
Mayuko Kanoorcid

DOI: https://doi.org/10.3803/EnM.2024.1989 [Epub ahead of print]
Published online: June 10, 2024
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Department of Metabolism and Endocrinology, St. Marianna University School of Medicine, Kawasaki, Japan
Corresponding author:  Mayuko Kano, Tel: +82-44-977-8111, Fax: +82-44-976-8941, 
Email: kano@marianna-u.ac.jp
Received: 25 March 2024   • Revised: 17 April 2024   • Accepted: 7 May 2024

Patients with permanent hypoparathyroidism require lifelong treatment. Current replacement therapies sometimes have adverse effects (e.g., hypercalciuria and chronic kidney disease). Generating parathyroid glands (PTGs) from the patient’s own induced pluripotent stem cells (PSCs), with transplantation of these PTGs, would be an effective treatment option. Multiple methods for generating PTGs from PSCs have been reported. One major trend is in vitro differentiation of PSCs into PTGs. Another is in vivo generation of PSC-derived PTGs by injecting PSCs into PTG-deficient embryos. This review discusses current achievements and challenges in present and future PTG regenerative medicine.

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