Endocrinol Metab > Volume 24(2); 2009 > Article
Journal of Korean Endocrine Society 2009;24(2):132-137.
DOI: https://doi.org/10.3803/jkes.2009.24.2.132    Published online June 1, 2009.
A Case of Pseudohypoparathyroidism without Albright's Hereditary Osteodystrophy in an Adult.
Yoonbum Lee, Jungmin Roh, Jeong seon Yoo, Jeongwoo Han, Jisun Nam, Minho Cho, Jongsuk Park, Chulwoo Ahn, Kyungrae Kim
Department of Internal Medicine, Yonsei University of College of Medicine, Korea.
Abstract
Pseudohypoparathyroidism is a rare disease caused by resistance to parathyroid hormone, and is associated with typical clinical typical symptoms such as tetany and seizures, hypocalcemia, hyperphosphatemia and increased parathyroid hormone levels. Pseudohypoparathyroidism is classified to Type Ia, Ib, Ic and II according to the clinical and biochemical manifestations. Type Ia and Ic have morphological characteristics called Albright's hereditary osteodystrophy. Type Ib differs from type II for the pathogenesis. Type Ib may~receptors and type II may~ pathway, but the pathophysiology of type II is not clear yet. Administration of parathyroid hormone extract may help to distinguish between the two types. We report a case of a pseudohypoparathyroidism type Ib or II patient who had tetany, hypocalcemia and hyperphosphatemia with normal morphologic features.
Key Words: hypocalcemia, pseudohypoparathyroidism


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