Warning: fopen(/home/virtual/enm-kes/journal/upload/ip_log/ip_log_2024-03.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 88 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 89 Effect of Hyperthyroidism on Preventing Renal Insufficiency
Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Articles

Page Path
HOME > Endocrinol Metab > Volume 37(2); 2022 > Article
Editorial
Thyroid Effect of Hyperthyroidism on Preventing Renal Insufficiency
Tae Yong Kimorcid
Endocrinology and Metabolism 2022;37(2):220.
DOI: https://doi.org/10.3803/EnM.2022.201
Published online: April 25, 2022

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Corresponding author: Tae Yong Kim. Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea Tel: +82-2-3010-3249, Fax: +82-2-3010-6962, E-mail: tykim@amc.seoul.kr
• Received: March 28, 2022   • Accepted: April 1, 2022

Copyright © 2022 Korean Endocrine Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • 2,072 Views
  • 88 Download
Both hyperthyroidism and hypothyroidism affect the glomerular filtration rate (GFR), tubular function, and electrolyte homeostasis; these effects are reversible after restoring euthyroidism [1]. Many studies have shown that hypothyroidism has a definite effect on renal function. However, only a few clinical studies have investigated the effect of hyperthyroidism on renal function, most likely due to the low prevalence of hyperthyroidism. Furthermore, most previous studies recruited a limited number of patients with a relatively short-term follow-up period. To fill in the missing pieces, we need a large-scale epidemiological study with long-term follow-up investigating the effect of hyperthyroidism on renal dysfunction.
As described in their article published in this issue, Cho et al. [2] have found a piece of the puzzle, answering a key question: “Do patients with Graves’ disease (GD) have a higher risk for developing end-stage renal disease (ESRD)?”
Cho et al. [2] retrospectively analyzed claims-based data from the Korean National Health Insurance Database and biannual health checkup data to determine the risk of developing ESRD in the GD population compared with matched healthy controls (over 400,000 subjects in each group). They found that GD patients had an almost 50% lower risk of developing ESRD than matched controls. They also showed supporting data from subgroup analyses. A higher baseline GFR, a longer treatment duration, and a higher cumulative dose of medication for GD were significant protective factors against ESRD.
This is the first epidemiological study investigating the effect of GD on renal dysfunction with long-term follow-up. I hope that this study will clarify directions for further clinical studies to prove the benefit of levothyroxine treatment for those who are susceptible to renal insufficiency, such as elderly patients and those with diabetes or hypertension.

CONFLICTS OF INTEREST

No potential conflict of interest relevant to this article was reported.

  • 1. Iglesias P, Bajo MA, Selgas R, Diez JJ. Thyroid dysfunction and kidney disease: an update. Rev Endocr Metab Disord 2017;18:131–44.ArticlePubMed
  • 2. Cho YY, Kim B, Shin DW, Jang HR, Kim BY, Jung CH, et al. Graves’ disease and the risk of end-stage renal disease: a Korean population-based study. Endocrine Metab 2022;37:281–9.Article

Figure & Data

References

    Citations

    Citations to this article as recorded by  

      Related articles

      Endocrinol Metab : Endocrinology and Metabolism