2. Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME. Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms. Circ Res 2015;116:991-1006.
[PUBMED] [PMC]
3. Nakamura K, Fuster JJ, Walsh K. Adipokines: a link between obesity and cardiovascular disease. J Cardiol 2014;63:250-9.
[CROSSREF] [PUBMED]
4. Barnes AS. The epidemic of obesity and diabetes: trends and treatments. Tex Heart Inst J 2011;38:142-4.
[PUBMED] [PMC]
5. Azim SF, Akhter QS, Akter T, Farid F. Obesity and dyslipidemia: risk factors for development of senile cataract. J Bangladesh Soc Physiol 2018;13:29-34.
[CROSSREF]
6. Leske MC, Wu SY, Hennis A, Connell AM, Hyman L, Schachat A. Diabetes, hypertension, and central obesity as cataract risk factors in a black population: the Barbados Eye Study. Ophthalmology 1999;106:35-41.
[CROSSREF] [PUBMED]
7. Reddy PY, Giridharan NV, Balakrishna N, Validandi V, Pullakhandam R, Reddy GB. Increased risk of cataract development in WNIN-obese rats due to accumulation of intralenticular sorbitol. IUBMB Life 2013;65:472-8.
[CROSSREF] [PUBMED]
9. Klein BE, Klein R, Moss SE. Incidence of cataract surgery in the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Am J Ophthalmol 1995;119:295-300.
[CROSSREF] [PUBMED]
10. Klein BE, Klein R, Moss SE. Prevalence of cataracts in a population-based study of persons with diabetes mellitus. Ophthalmology 1985;92:1191-6.
[CROSSREF] [PUBMED]
11. Klein R, Klein BE, Moss SE. Visual impairment in diabetes. Ophthalmology 1984;91:1-9.
[CROSSREF]
12. Cruz DN. Midodrine: a selective alpha-adrenergic agonist for orthostatic hypotension and dialysis hypotension. Expert Opin Pharmacother 2000;1:835-40.
[PUBMED]
13. Beak J, Huang W, Parker JS, Hicks ST, Patterson C, Simpson PC, et al. An oral selective alpha-1A adrenergic receptor agonist prevents doxorubicin cardiotoxicity. JACC Basic Transl Sci 2017;2:39-53.
[CROSSREF] [PUBMED] [PMC]
14. Han YM, Lee YJ, Jang YN, Kim HM, Seo HS, Jung TW, et al. Aspirin improves nonalcoholic fatty liver disease and atherosclerosis through regulation of the PPARδ-AMPKPGC-1α pathway in dyslipidemic conditions. Biomed Res Int 2020;2020:7806860.
[PUBMED] [PMC]
15. Lee YJ, Jang YN, Han YM, Kim HM, Seo HS. 6-Gingerol normalizes the expression of biomarkers related to hypertension via PPARδ in HUVECs, HEK293, and differentiated 3T3-L1 cells. PPAR Res 2018;2018:6485064.
[CROSSREF] [PUBMED] [PMC]
16. Kinoshita JH, Fukushi S, Kador P, Merola LO. Aldose reductase in diabetic complications of the eye. Metabolism 1979;28(4 Suppl 1):462-9.
[CROSSREF] [PUBMED]
17. Tataranni PA. Pathophysiology of obesity-induced insulin resistance and type 2 diabetes mellitus. Eur Rev Med Pharmacol Sci 2002;6:27-32.
[PUBMED]
18. Noran NH, Nooriah S, Mimiwati Z. The association between body mass index and age related cataract. Med J Malaysia 2007;62:49-52.
[PUBMED]
19. Weintraub JM, Willett WC, Rosner B, Colditz GA, Seddon JM, Hankinson SE. A prospective study of the relationship between body mass index and cataract extraction among US women and men. Int J Obes Relat Metab Disord 2002;26:1588-95.
[CROSSREF] [PUBMED]
20. Schaumberg DA, Glynn RJ, Christen WG, Hankinson SE, Hennekens CH. Relations of body fat distribution and height with cataract in men. Am J Clin Nutr 2000;72:1495-502.
[CROSSREF] [PUBMED]
21. Hiller R, Podgor MJ, Sperduto RD, Nowroozi L, Wilson PW, D’Agostino RB, et al. A longitudinal study of body mass index and lens opacities: the Framingham Studies. Ophthalmology 1998;105:1244-50.
[CROSSREF] [PUBMED]
22. Hamid S, Gul A, Hamid Q. Relationship of cytokines and AGE products in diabetic and non-diabetic patients with cataract. Int J Health Sci (Qassim) 2016;10:507-15.
[CROSSREF] [PUBMED] [PMC]
23. Lee H, Lee IS, Choue R. Obesity, inflammation and diet. Pediatr Gastroenterol Hepatol Nutr 2013;16:143-52.
[CROSSREF] [PUBMED] [PMC]
24. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003;112:1821-30.
[CROSSREF] [PUBMED] [PMC]
25. Ellulu MS, Patimah I, Khaza’ai H, Rahmat A, Abed Y. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci 2017;13:851-63.
[CROSSREF] [PUBMED]
26. Lee YJ, Kim HS, Seo HS, Na JO, Jang YN, Han YM, et al. Stimulation of alpha1-adrenergic receptor ameliorates cellular functions of multiorgans beyond vasomotion through PPARδ. PPAR Res 2020;2020:3785137.
[PUBMED] [PMC]
27. Fernandez-Sanchez A, Madrigal-Santillan E, Bautista M, Esquivel-Soto J, Morales-Gonzalez A, Esquivel-Chirino C, et al. Inflammation, oxidative stress, and obesity. Int J Mol Sci 2011;12:3117-32.
[CROSSREF] [PUBMED] [PMC]
28. Nogueira-Machado JA, Chaves MM. From hyperglycemia to AGE-RAGE interaction on the cell surface: a dangerous metabolic route for diabetic patients. Expert Opin Ther Targets 2008;12:871-82.
[CROSSREF] [PUBMED]
29. Spector A, Garner WH. Hydrogen peroxide and human cataract. Exp Eye Res 1981;33:673-81.
[CROSSREF] [PUBMED]
30. Kaur J, Kukreja S, Kaur A, Malhotra N, Kaur R. The oxidative stress in cataract patients. J Clin Diagn Res 2012;6:1629-32.
[CROSSREF] [PUBMED] [PMC]
31. Matsui H, Lin LR, Ho YS, Reddy VN. The effect of up- and downregulation of MnSOD enzyme on oxidative stress in human lens epithelial cells. Invest Ophthalmol Vis Sci 2003;44:3467-75.
[CROSSREF] [PUBMED]
32. Lin D, Barnett M, Grauer L, Robben J, Jewell A, Takemoto L, et al. Expression of superoxide dismutase in whole lens prevents cataract formation. Mol Vis 2005;11:853-8.
[PUBMED]
33. Sippel TO. Energy metabolism in the lens during development of galactose cataract in rats. Invest Ophthalmol 1966;5:576-82.
[PUBMED]
34. Wong TY. The ophthalmology examinations review. Singapore: World Scientific Publishing Company; 2001. p. 4.
[CROSSREF]
35. Ushiama S, Ishimaru Y, Narukawa M, Yoshioka M, Kozuka C, Watanabe N, et al. Catecholamines facilitate fuel expenditure and protect against obesity via a novel network of the gut-brain axis in transcription factor Skn-1-deficient mice. EBioMedicine 2016;8:60-71.
[CROSSREF] [PUBMED] [PMC]
36. Hutchinson DS, Bengtsson T. alpha1A-adrenoceptors activate glucose uptake in L6 muscle cells through a phospholipase C-, phosphatidylinositol-3 kinase-, and atypical protein kinase C-dependent pathway. Endocrinology 2005;146:901-12.
[PUBMED]
37. Willis MS, Ilaiwy A, Montgomery MD, Simpson PC, Jensen BC. The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid and endocannabinoid metabolites associated with inflammation in vivo. Metabolomics 2016;12:155.
[CROSSREF] [PUBMED] [PMC]
38. Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky JM, et al. PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A 2006;103:3444-9.
[PUBMED] [PMC]
39. Stoppani J, Hildebrandt AL, Sakamoto K, Cameron-Smith D, Goodyear LJ, Neufer PD. AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle. Am J Physiol Endocrinol Metab 2002;283:E1239-48.
[PUBMED]
40. Srivastava S, Barrett JN, Moraes CT. PGC-1alpha/beta upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations. Hum Mol Genet 2007;16:993-1005.
[CROSSREF] [PUBMED]
41. Wan Z, Root-McCaig J, Castellani L, Kemp BE, Steinberg GR, Wright DC. Evidence for the role of AMPK in regulating PGC-1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue. Obesity (Silver Spring) 2014;22:730-8.
[CROSSREF] [PUBMED]
42. Jager S, Handschin C, St-Pierre J, Spiegelman BM. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A 2007;104:12017-22.
[PUBMED] [PMC]
43. Lee YJ, Jang YN, Han YM, Kim HM, Jeong JM, Son MJ, et al. Caffeoylquinic acid-rich extract of Aster glehni F. Schmidt ameliorates nonalcoholic fatty liver through the regulation of PPARδ and adiponectin in ApoE KO mice. PPAR Res 2017;2017:3912567.
[PUBMED] [PMC]
44. Tsutsumi K, Inoue Y, Yoshida C. Acceleration of development of diabetic cataract by hyperlipidemia and low high-density lipoprotein in rats. Biol Pharm Bull 1999;22:37-41.
[CROSSREF] [PUBMED]