1. Braverman LE, Cooper DS, Kopp PA. Werner & Ingbar’s the thyroid; 11th ed. Philadelphia: Wolters Kluwer; 2021. Chapter 50:Subclinical hypothyroidism. p. 635-40.
2. Cooper DS. Clinical practice. Subclinical hypothyroidism. N Engl J Med 2001;345:260-5.
[CROSSREF] [PUBMED]
3. Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev 2008;29:76-131.
[CROSSREF] [PUBMED]
4. Hansen PS, Brix TH, Sorensen TI, Kyvik KO, Hegedus L. Major genetic influence on the regulation of the pituitary-thyroid axis: a study of healthy Danish twins. J Clin Endocrinol Metab 2004;89:1181-7.
[CROSSREF] [PUBMED]
5. Kim WG, Kim WB, Woo G, Kim H, Cho Y, Kim TY, et al. Thyroid stimulating hormone reference range and prevalence of thyroid dysfunction in the Korean population: Korea National Health and Nutrition Examination Survey 2013 to 2015. Endocrinol Metab (Seoul) 2017;32:106-14.
[CROSSREF] [PUBMED] [PMC] [PDF]
6. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002;87:489-99.
[CROSSREF] [PUBMED]
7. Cooper DS, Biondi B. Subclinical thyroid disease. Lancet 2012;379:1142-54.
[CROSSREF] [PUBMED]
8. Mendes D, Alves C, Silverio N, Batel Marques F. Prevalence of undiagnosed hypothyroidism in Europe: a systematic review and meta-analysis. Eur Thyroid J 2019;8:130-43.
[CROSSREF] [PUBMED] [PMC]
9. Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, et al. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 1977;7:481-93.
[CROSSREF] [PUBMED]
10. Nystrom E, Bengtsson C, Lindquist O, Noppa H, Lindstedt G, Lundberg PA. Thyroid disease and high concentration of serum thyrotrophin in a population sample of women. A 4-year follow-up. Acta Med Scand 1981;210:39-46.
[PUBMED]
11. Drinka PJ, Nolten WE. Prevalence of previously undiagnosed hypothyroidism in residents of a midwestern nursing home. South Med J 1990;83:1259-61. 1265.
[CROSSREF] [PUBMED]
12. Konno N, Yuri K, Taguchi H, Miura K, Taguchi S, Hagiwara K, et al. Screening for thyroid diseases in an iodine sufficient area with sensitive thyrotrophin assays, and serum thyroid autoantibody and urinary iodide determinations. Clin Endocrinol (Oxf) 1993;38:273-81.
[CROSSREF] [PUBMED]
13. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med 2000;160:526-34.
[CROSSREF] [PUBMED]
14. Hoogendoorn EH, Hermus AR, de Vegt F, Ross HA, Verbeek AL, Kiemeney LA, et al. Thyroid function and prevalence of anti-thyroperoxidase antibodies in a population with borderline sufficient iodine intake: influences of age and sex. Clin Chem 2006;52:104-11.
[CROSSREF] [PUBMED]
15. Perez-Campos Mayoral L, Hernandez-Huerta MT, Mayoral-Andrade G, Perez-Campo Mayoral E, Zenteno E, Martinez-Cruz R, et al. TSH levels in subclinical hypothyroidism in the 97.5th percentile of the population. Int J Endocrinol 2020;2020:2698627.
[PUBMED] [PMC]
16. Chung JH. Evaluation of thyroid hormone levels and urinary iodine concentrations in Koreans based on the data from Korea National Health and Nutrition Examination Survey VI (2013 to 2015). Endocrinol Metab (Seoul) 2018;33:160-3.
[CROSSREF] [PUBMED] [PMC]
17. Biondi B. The normal TSH reference range: what has changed in the last decade? J Clin Endocrinol Metab 2013;98:3584-7.
[CROSSREF] [PUBMED]
18. Surks MI, Hollowell JG. Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism. J Clin Endocrinol Metab 2007;92:4575-82.
[CROSSREF] [PUBMED]
19. Chung JH. Update on thyroid hormone levels and thyroid dysfunction in the Korean population based on data from the Korea National Health and Nutrition Examination Survey VI (2013 to 2015). Endocrinol Metab (Seoul) 2020;35:7-13.
[CROSSREF] [PUBMED] [PMC]
20. Park SY, Kim HI, Oh HK, Kim TH, Jang HW, Chung JH, et al. Age- and gender-specific reference intervals of TSH and free T4 in an iodine-replete area: data from Korean National Health and Nutrition Examination Survey IV (2013-2015). PLoS One 2018;13:e0190738.
[CROSSREF] [PUBMED] [PMC]
21. Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, et al. 2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid 2017;27:315-89.
[CROSSREF] [PUBMED]
22. Li C, Shan Z, Mao J, Wang W, Xie X, Zhou W, et al. Assessment of thyroid function during first-trimester pregnancy: what is the rational upper limit of serum TSH during the first trimester in Chinese pregnant women? J Clin Endocrinol Metab 2014;99:73-9.
[CROSSREF] [PUBMED]
23. Moon HW, Chung HJ, Park CM, Hur M, Yun YM. Establishment of trimester-specific reference intervals for thyroid hormones in Korean pregnant women. Ann Lab Med 2015;35:198-204.
[CROSSREF] [PUBMED] [PMC]
24. Peeters RP. Subclinical hypothyroidism. N Engl J Med 2017;376:2556-65.
[CROSSREF] [PUBMED]
25. Biondi B, Cappola AR, Cooper DS. Subclinical hypothyroidism: a review. JAMA 2019;322:153-60.
[CROSSREF] [PUBMED]
26. Andersen S, Pedersen KM, Bruun NH, Laurberg P. Narrow individual variations in serum T(4) and T(3) in normal subjects: a clue to the understanding of subclinical thyroid disease. J Clin Endocrinol Metab 2002;87:1068-72.
[CROSSREF] [PUBMED]
27. Kim YA, Park YJ. Prevalence and risk factors of subclinical thyroid disease. Endocrinol Metab (Seoul) 2014;29:20-9.
[CROSSREF] [PUBMED] [PMC]
28. Walsh JP, Bremner AP, Feddema P, Leedman PJ, Brown SJ, O’Leary P. Thyrotropin and thyroid antibodies as predictors of hypothyroidism: a 13-year, longitudinal study of a community-based cohort using current immunoassay techniques. J Clin Endocrinol Metab 2010;95:1095-104.
[CROSSREF] [PUBMED]
29. Moore DC. Natural course of ‘subclinical’ hypothyroidism in childhood and adolescence. Arch Pediatr Adolesc Med 1996;150:293-7.
[CROSSREF] [PUBMED]
30. Meyerovitch J, Rotman-Pikielny P, Sherf M, Battat E, Levy Y, Surks MI. Serum thyrotropin measurements in the community: five-year follow-up in a large network of primary care physicians. Arch Intern Med 2007;167:1533-8.
[CROSSREF] [PUBMED]
31. Volzke H, Alte D, Kohlmann T, Ludemann J, Nauck M, John U, et al. Reference intervals of serum thyroid function tests in a previously iodine-deficient area. Thyroid 2005;15:279-85.
[CROSSREF] [PUBMED]
32. Caron PJ, Nieman LK, Rose SR, Nisula BC. Deficient nocturnal surge of thyrotropin in central hypothyroidism. J Clin Endocrinol Metab 1986;62:960-4.
[CROSSREF] [PUBMED]
33. Kim TH, Kim KW, Ahn HY, Choi HS, Won H, Choi Y, et al. Effect of seasonal changes on the transition between subclinical hypothyroid and euthyroid status. J Clin Endocrinol Metab 2013;98:3420-9.
[CROSSREF] [PUBMED]
34. Hennessey JV, Espaillat R. Subclinical hypothyroidism: a historical view and shifting prevalence. Int J Clin Pract 2015;69:771-82.
[CROSSREF] [PUBMED] [PMC]
35. Lee MW, Shin DY, Kim KJ, Hwang S, Lee EJ. The biochemical prognostic factors of subclinical hypothyroidism. Endocrinol Metab (Seoul) 2014;29:154-62.
[CROSSREF] [PUBMED] [PMC]
36. Huber G, Staub JJ, Meier C, Mitrache C, Guglielmetti M, Huber P, et al. Prospective study of the spontaneous course of subclinical hypothyroidism: prognostic value of thyrotropin, thyroid reserve, and thyroid antibodies. J Clin Endocrinol Metab 2002;87:3221-6.
[CROSSREF] [PUBMED]
37. Diez JJ, Iglesias P. Spontaneous subclinical hypothyroidism in patients older than 55 years: an analysis of natural course and risk factors for the development of overt thyroid failure. J Clin Endocrinol Metab 2004;89:4890-7.
[CROSSREF] [PUBMED]
38. Konno N, Makita H, Yuri K, Iizuka N, Kawasaki K. Association between dietary iodine intake and prevalence of subclinical hypothyroidism in the coastal regions of Japan. J Clin Endocrinol Metab 1994;78:393-7.
[CROSSREF] [PUBMED]
39. Cho NH, Choi HS, Kim KW, Kim HL, Lee SY, Choi SH, et al. Interaction between cigarette smoking and iodine intake and their impact on thyroid function. Clin Endocrinol (Oxf) 2010;73:264-70.
[CROSSREF] [PUBMED]
40. Willms A, Bieler D, Wieler H, Willms D, Kaiser KP, Schwab R. Correlation between sonography and antibody activity in patients with Hashimoto thyroiditis. J Ultrasound Med 2013;32:1979-86.
[CROSSREF] [PUBMED]
41. Mariotti S, Franceschi C, Cossarizza A, Pinchera A. The aging thyroid. Endocr Rev 1995;16:686-715.
[CROSSREF] [PUBMED]
42. Boucai L, Hollowell JG, Surks MI. An approach for development of age-, gender-, and ethnicity-specific thyrotropin reference limits. Thyroid 2011;21:5-11.
[CROSSREF] [PUBMED] [PMC]
43. Gussekloo J, van Exel E, de Craen AJ, Meinders AE, Frolich M, Westendorp RG. Thyroid status, disability and cognitive function, and survival in old age. JAMA 2004;292:2591-9.
[CROSSREF] [PUBMED]
44. Hyland KA, Arnold AM, Lee JS, Cappola AR. Persistent subclinical hypothyroidism and cardiovascular risk in the elderly: the cardiovascular health study. J Clin Endocrinol Metab 2013;98:533-40.
[CROSSREF] [PUBMED]
45. Pasqualetti G, Pagano G, Rengo G, Ferrara N, Monzani F. Subclinical hypothyroidism and cognitive impairment: systematic review and meta-analysis. J Clin Endocrinol Metab 2015;100:4240-8.
[CROSSREF] [PUBMED]
46. Stott DJ, Rodondi N, Kearney PM, Ford I, Westendorp RGJ, Mooijaart SP, et al. Thyroid hormone therapy for older adults with subclinical hypothyroidism. N Engl J Med 2017;376:2534-44.
[CROSSREF] [PUBMED]
47. Lazarus J, Brown RS, Daumerie C, Hubalewska-Dydejczyk A, Negro R, Vaidya B. 2014 European Thyroid Association guidelines for the management of subclinical hypothyroidism in pregnancy and in children. Eur Thyroid J 2014;3:76-94.
[CROSSREF] [PUBMED] [PMC]
48. Kang MJ, Hwang IT, Chung HR. Excessive iodine intake and subclinical hypothyroidism in children and adolescents aged 6-19 years: results of the sixth Korean National Health and Nutrition Examination Survey, 2013-2015. Thyroid 2018;28:773-9.
[CROSSREF] [PUBMED]
49. Cerbone M, Bravaccio C, Capalbo D, Polizzi M, Wasniewska M, Cioffi D, et al. Linear growth and intellectual outcome in children with long-term idiopathic subclinical hypothyroidism. Eur J Endocrinol 2011;164:591-7.
[CROSSREF] [PUBMED]
50. Wasniewska M, Aversa T, Salerno M, Corrias A, Messina MF, Mussa A, et al. Five-year prospective evaluation of thyroid function in girls with subclinical mild hypothyroidism of different etiology. Eur J Endocrinol 2015;173:801-8.
[CROSSREF] [PUBMED]
51. Aversa T, Valenzise M, Corrias A, Salerno M, De Luca F, Mussa A, et al. Underlying Hashimoto’s thyroiditis negatively affects the evolution of subclinical hypothyroidism in children irrespective of other concomitant risk factors. Thyroid 2015;25:183-7.
[CROSSREF] [PUBMED]
52. Lee YJ, Jung SY, Jung HW, Kim SY, Lee YA, Lee SY, et al. Unfavorable course of subclinical hypothyroidism in children with Hashimoto’s thyroiditis compared to those with isolated non-autoimmune hyperthyrotropinemia. J Korean Med Sci 2017;32:124-9.
[CROSSREF] [PUBMED]
53. Crisafulli G, Aversa T, Zirilli G, Pajno GB, Corica D, De Luca F, et al. Subclinical hypothyroidism in children: when a replacement hormonal treatment might be advisable. Front Endocrinol (Lausanne) 2019;10:109.
[CROSSREF] [PUBMED] [PMC]
54. Arafah BM. Increased need for thyroxine in women with hypothyroidism during estrogen therapy. N Engl J Med 2001;344:1743-9.
[CROSSREF] [PUBMED]
55. Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev 1997;18:404-33.
[CROSSREF] [PUBMED]
56. Stricker R, Echenard M, Eberhart R, Chevailler MC, Perez V, Quinn FA, et al. Evaluation of maternal thyroid function during pregnancy: the importance of using gestational age-specific reference intervals. Eur J Endocrinol 2007;157:509-14.
[CROSSREF] [PUBMED]
57. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid 2011;21:1081-125.
[CROSSREF] [PUBMED] [PMC]
58. Maraka S, Ospina NM, O’Keeffe DT, Espinosa De Ycaza AE, Gionfriddo MR, Erwin PJ, et al. Subclinical hypothyroidism in pregnancy: a systematic review and meta-analysis. Thyroid 2016;26:580-90.
[CROSSREF] [PUBMED] [PMC]
59. Consortium on Thyroid and Pregnancy-Study Group on Preterm Birth. Korevaar TIM, Derakhshan A, Taylor PN, Meima M, Chen L, et al. Association of thyroid function test abnormalities and thyroid autoimmunity with preterm birth: a systematic review and meta-analysis. JAMA 2019;322:632-41.
[CROSSREF] [PUBMED] [PMC]
60. Correia N, Mullally S, Cooke G, Tun TK, Phelan N, Feeney J, et al. Evidence for a specific defect in hippocampal memory in overt and subclinical hypothyroidism. J Clin Endocrinol Metab 2009;94:3789-97.
[CROSSREF] [PUBMED]
61. Zhu DF, Wang ZX, Zhang DR, Pan ZL, He S, Hu XP, et al. fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism. Brain 2006;129(Pt 11):2923-30.
[CROSSREF] [PUBMED]
62. Jorde R, Waterloo K, Storhaug H, Nyrnes A, Sundsfjord J, Jenssen TG. Neuropsychological function and symptoms in subjects with subclinical hypothyroidism and the effect of thyroxine treatment. J Clin Endocrinol Metab 2006;91:145-53.
[CROSSREF] [PUBMED]
63. Loh HH, Lim LL, Yee A, Loh HS. Association between subclinical hypothyroidism and depression: an updated systematic review and meta-analysis. BMC Psychiatry 2019;19:12.
[CROSSREF] [PUBMED] [PMC]
64. Zhao T, Chen BM, Zhao XM, Shan ZY. Subclinical hypothyroidism and depression: a meta-analysis. Transl Psychiatry 2018;8:239.
[CROSSREF] [PUBMED] [PMC]
65. Demartini B, Ranieri R, Masu A, Selle V, Scarone S, Gambini O. Depressive symptoms and major depressive disorder in patients affected by subclinical hypothyroidism: a cross-sectional study. J Nerv Ment Dis 2014;202:603-7.
[PUBMED]
66. Park YJ, Lee EJ, Lee YJ, Choi SH, Park JH, Lee SB, et al. Subclinical hypothyroidism (SCH) is not associated with metabolic derangement, cognitive impairment, depression or poor quality of life (QoL) in elderly subjects. Arch Gerontol Geriatr 2010;50:e68-73.
[CROSSREF] [PUBMED]
67. Kim JS, Zhang Y, Chang Y, Ryu S, Guallar E, Shin YC, et al. Subclinical hypothyroidism and incident depression in young and middle-age adults. J Clin Endocrinol Metab 2018;103:1827-33.
[CROSSREF] [PUBMED]
68. Panicker V, Evans J, Bjoro T, Asvold BO, Dayan CM, Bjerkeset O. A paradoxical difference in relationship between anxiety, depression and thyroid function in subjects on and not on T4: findings from the HUNT study. Clin Endocrinol (Oxf) 2009;71:574-80.
[CROSSREF] [PUBMED]
69. Feller M, Snel M, Moutzouri E, Bauer DC, de Montmollin M, Aujesky D, et al. Association of thyroid hormone therapy with quality of life and thyroid-related symptoms in patients with subclinical hypothyroidism: a systematic review and meta-analysis. JAMA 2018;320:1349-59.
[CROSSREF] [PUBMED] [PMC]
70. Mooijaart SP, Du Puy RS, Stott DJ, Kearney PM, Rodondi N, Westendorp RGJ, et al. Association between levothyroxine treatment and thyroid-related symptoms among adults aged 80 years and older with subclinical hypothyroidism. JAMA 2019;322:1977-86.
[CROSSREF] [PUBMED] [PMC]
71. Oiwa A, Minemura K, Nishio SI, Yamazaki M, Komatsu M. Implications of thyroid autoimmunity in infertile women with subclinical hypothyroidism in the absence of both goiter and anti-thyroid antibodies: lessons from three cases. Endocr J 2019;66:193-8.
[CROSSREF] [PUBMED]
72. Chen X, Zhang N, Cai Y, Shi J. Evaluation of left ventricular diastolic function using tissue Doppler echocardiography and conventional doppler echocardiography in patients with subclinical hypothyroidism aged <60 years: a meta-analysis. J Cardiol 2013;61:8-15.
[CROSSREF] [PUBMED]
73. Owen PJ, Sabit R, Lazarus JH. Thyroid disease and vascular function. Thyroid 2007;17:519-24.
[CROSSREF] [PUBMED]
74. Gao N, Zhang W, Zhang YZ, Yang Q, Chen SH. Carotid intima-media thickness in patients with subclinical hypothyroidism: a meta-analysis. Atherosclerosis 2013;227:18-25.
[CROSSREF] [PUBMED]
75. Hak AE, Pols HA, Visser TJ, Drexhage HA, Hofman A, Witteman JC. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med 2000;132:270-8.
[CROSSREF] [PUBMED]
76. Singh S, Duggal J, Molnar J, Maldonado F, Barsano CP, Arora R. Impact of subclinical thyroid disorders on coronary heart disease, cardiovascular and all- cause mortality: a meta-analysis. Int J Cardiol 2008;125:41-8.
[CROSSREF] [PUBMED]
77. Moon S, Kim MJ, Yu JM, Yoo HJ, Park YJ. Subclinical hypothyroidism and the risk of cardiovascular disease and all-cause mortality: a meta-analysis of prospective cohort studies. Thyroid 2018;28:1101-10.
[CROSSREF] [PUBMED]
78. Kim H, Kong SH, Moon JH, Kim SY, Park KH, Kim JS, et al. Subclinical hypothyroidism affects the long-term outcomes of patients who undergo coronary artery bypass grafting surgery but not heart valve surgery. Endocrinol Metab (Seoul) 2020;35:308-18.
[CROSSREF] [PUBMED] [PMC]
79. Baumgartner C, da Costa BR, Collet TH, Feller M, Floriani C, Bauer DC, et al. Thyroid function within the normal range, subclinical hypothyroidism, and the risk of atrial fibrillation. Circulation 2017;136:2100-16.
[CROSSREF] [PUBMED] [PMC]
80. Gencer B, Collet TH, Virgini V, Bauer DC, Gussekloo J, Cappola AR, et al. Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts. Circulation 2012;126:1040-9.
[CROSSREF] [PUBMED]
81. Chaker L, Baumgartner C, den Elzen WP, Ikram MA, Blum MR, Collet TH, et al. Subclinical hypothyroidism and the risk of stroke events and fatal stroke: an individual participant data analysis. J Clin Endocrinol Metab 2015;100:2181-91.
[CROSSREF] [PUBMED] [PMC]
82. Collet TH, Bauer DC, Cappola AR, Asvold BO, Weiler S, Vittinghoff E, et al. Thyroid antibody status, subclinical hypothyroidism, and the risk of coronary heart disease: an individual participant data analysis. J Clin Endocrinol Metab 2014;99:3353-62.
[CROSSREF] [PUBMED] [PMC]
83. Rodondi N, den Elzen WP, Bauer DC, Cappola AR, Razvi S, Walsh JP, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA 2010;304:1365-74.
[CROSSREF] [PUBMED] [PMC]
84. Redford C, Vaidya B. Subclinical hypothyroidism: should we treat? Post Reprod Health 2017;23:55-62.
[CROSSREF] [PUBMED]
85. Jabbar A, Ingoe L, Junejo S, Carey P, Addison C, Thomas H, et al. Effect of levothyroxine on left ventricular ejection fraction in patients with subclinical hypothyroidism and acute myocardial infarction: a randomized clinical trial. JAMA 2020;324:249-58.
[CROSSREF] [PUBMED]
86. Parsaik AK, Singh B, Roberts RO, Pankratz S, Edwards KK, Geda YE, et al. Hypothyroidism and risk of mild cognitive impairment in elderly persons: a population-based study. JAMA Neurol 2014;71:201-7.
[CROSSREF] [PUBMED] [PMC]
87. Rieben C, Segna D, da Costa BR, Collet TH, Chaker L, Aubert CE, et al. Subclinical thyroid dysfunction and the risk of cognitive decline: a meta-analysis of prospective cohort studies. J Clin Endocrinol Metab 2016;101:4945-54.
[CROSSREF] [PUBMED] [PMC]
88. Akintola AA, Jansen SW, van Bodegom D, van der Grond J, Westendorp RG, de Craen AJ, et al. Subclinical hypothyroidism and cognitive function in people over 60 years: a systematic review and meta-analysis. Front Aging Neurosci 2015;7:150.
[CROSSREF] [PUBMED] [PMC]
89. Blum MR, Bauer DC, Collet TH, Fink HA, Cappola AR, da Costa BR, et al. Subclinical thyroid dysfunction and fracture risk: a meta-analysis. JAMA 2015;313:2055-65.
[CROSSREF] [PUBMED] [PMC]
90. Segna D, Bauer DC, Feller M, Schneider C, Fink HA, Aubert CE, et al. Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts. J Intern Med 2018;283:56-72.
[CROSSREF] [PUBMED]
91. Siru R, Alfonso H, Chubb SAP, Golledge J, Flicker L, Yeap BB. Subclinical thyroid dysfunction and circulating thyroid hormones are not associated with bone turnover markers or incident hip fracture in older men. Clin Endocrinol (Oxf) 2018;89:93-9.
[CROSSREF] [PUBMED]
92. Virgini VS, Rodondi N, Cawthon PM, Harrison SL, Hoffman AR, Orwoll ES, et al. Subclinical thyroid dysfunction and frailty among older men. J Clin Endocrinol Metab 2015;100:4524-32.
[CROSSREF] [PUBMED] [PMC]
93. Virgini VS, Wijsman LW, Rodondi N, Bauer DC, Kearney PM, Gussekloo J, et al. Subclinical thyroid dysfunction and functional capacity among elderly. Thyroid 2014;24:208-14.
[CROSSREF] [PUBMED] [PMC]
94. Da Costa AB, Pellizzari C, Carvalho GA, Sant’Anna BC, Montenegro RL, Zammar Filho RG, et al. High prevalence of subclinical hypothyroidism and nodular thyroid disease in patients on hemodialysis. Hemodial Int 2016;20:31-7.
[CROSSREF] [PUBMED]
95. Shin DH, Lee MJ, Lee HS, Oh HJ, Ko KI, Kim CH, et al. Thyroid hormone replacement therapy attenuates the decline of renal function in chronic kidney disease patients with subclinical hypothyroidism. Thyroid 2013;23:654-61.
[CROSSREF] [PUBMED] [PMC]
96. Rhee CM, Kim S, Gillen DL, Oztan T, Wang J, Mehrotra R, et al. Association of thyroid functional disease with mortality in a national cohort of incident hemodialysis patients. J Clin Endocrinol Metab 2015;100:1386-95.
[CROSSREF] [PUBMED] [PMC]
97. Meuwese CL, van Diepen M, Cappola AR, Sarnak MJ, Shlipak MG, Bauer DC, et al. Low thyroid function is not associated with an accelerated deterioration in renal function. Nephrol Dial Transplant 2019;34:650-9.
[CROSSREF] [PUBMED]
98. Posadas-Romero C, Jorge-Galarza E, Posadas-Sanchez R, Acuna-Valerio J, Juarez-Rojas JG, Kimura-Hayama E, et al. Fatty liver largely explains associations of subclinical hypothyroidism with insulin resistance, metabolic syndrome, and subclinical coronary atherosclerosis. Eur J Endocrinol 2014;171:319-25.
[CROSSREF] [PUBMED]
99. Liu L, Yu Y, Zhao M, Zheng D, Zhang X, Guan Q, et al. Benefits of levothyroxine replacement therapy on nonalcoholic fatty liver disease in subclinical hypothyroidism patients. Int J Endocrinol 2017;2017:5753039.
[CROSSREF] [PUBMED] [PMC]
100. Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract 2012;18:988-1028.
[CROSSREF] [PUBMED]
101. Pearce SH, Brabant G, Duntas LH, Monzani F, Peeters RP, Razvi S, et al. 2013 ETA guideline: management of subclinical hypothyroidism. Eur Thyroid J 2013;2:215-28.
[CROSSREF] [PUBMED] [PMC]
104. Bekkering GE, Agoritsas T, Lytvyn L, Heen AF, Feller M, Moutzouri E, et al. Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline. BMJ 2019;365:l2006.
[CROSSREF] [PUBMED]
105. Ruggeri RM, Trimarchi F, Biondi B. Management of endocrine disease: l-thyroxine replacement therapy in the frail elderly: a challenge in clinical practice. Eur J Endocrinol 2017;177:R199-217.
[CROSSREF] [PUBMED]
106. Cooper DS. Thyroid disease in the oldest old: the exception to the rule. JAMA 2004;292:2651-4.
[CROSSREF] [PUBMED]
107. Calissendorff J, Falhammar H. To treat or not to treat subclinical hypothyroidism, what is the evidence? Medicina (Kaunas) 2020;56:40.
[CROSSREF] [PUBMED] [PMC]
108. Taylor P, Bianco AC. Urgent need for further research in subclinical hypothyroidism. Nat Rev Endocrinol 2019;15:503-4.
[CROSSREF] [PUBMED] [PMC]