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1Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea
2Department of Internal Medicine, Seoul National University Hospital, Chung-Ang University College of Medicine, Seoul, Korea
3Division of Endocrinology, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea
4Department of Pathology, Chung-Ang University College of Medicine, Seoul, Korea
5Department of Breast and Endocrine Surgery, Hallym University Sacred Heart Hospital, Anyang, Korea
6Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea
7Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea
8Department of Radiology, School of Medicine, Kangwon National University Hospital, Chuncheon, Korea
9Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea
10Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea
11Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
Copyright © 2021 Korean Endocrine Society
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICTS OF INTEREST
No potential conflict of interest relevant to this article was reported.
AUTHOR CONTRIBUTIONS
Conception or design: Y.J.P., K.H.Y., C.K.J., B.H.K. Acquisition, analysis, or interpretation of data: M.K., S.W.C., H.Y.A., H.S.K., Y.J.S., D.C., B.K.K., G.E.Y., I.S.P., K.H.Y., C.K.J., B.H.K. Drafting the work or revising: M.K., S.W.C., C.K.J., B.H.K. Final approval of the manuscript: M.K., S.W.C., H.Y.A., H.S.K., Y.J.S., D.C., B.K.K., G.E.Y., I.S.P., K.H.Y., C.K.J., B.H.K.
Patient | Age, yr | Sex | Primary tumor size, cm | TNM stagea | Metastatic LNs | Background | US categoryb | Recur | Recurred area | RFS, mo |
---|---|---|---|---|---|---|---|---|---|---|
1 | 33 | M | 3.5 | T3N1aM0 | 29 | None | Intermediate | Yes | Lat. neck LNs | 6 |
2 | 21 | F | 1.1 | T1N1aM0 | 6 | HT | Intermediate | Yes | Lat. neck LNs | 51 |
3 | 32 | F | 2.0 | T3N1bM0 | 22 | HT | High | No | - | 88 |
4 | 26 | F | 0.9 | T1N1aM0 | 2 | HT | High | No | - | 67 |
Characteristic | Value |
---|---|
Number of patients | 63 |
| |
Age, yr | 42.1±13.1 |
| |
Male patients | 10 (15.9) |
| |
Pathology, variant | |
Tall cell | 51 (81.0) |
Columnar cell | 1 (1.6) |
Diffuse sclerosing | 4 (6.3) |
Cribriform-morular | 3 (4.8) |
Solid | 4 (6.3) |
Hobnail | 0 |
Warthin-like | 0 |
| |
Primary tumor size, cm | 1.3±0.9 |
| |
Lymphovascular invasion | 22 (34.9) |
| |
Extrathyroidal extension | |
Microscopic | 30 (47.6) |
Gross | 8 (12.7) |
| |
Cervical LN metastasis | |
N1a | 29 (46.0) |
N1b | 8 (12.7) |
| |
Distant metastasis | 0 |
| |
Total thyroidectomy | 59 (93.7) |
| |
RAI | 53 (84.1) |
| |
RAI dose, mCi | 104.4±74.8 |
Variable | Number (%) |
---|---|
ATA classification | |
High suspicion | 45 (75.0) |
Intermediate suspicion | 15 (25.0) |
Low suspicion | 0 |
Very low suspicion | 0 |
Benign | 0 |
| |
Echogenicity | |
Hypoechoic | 50 (83.3) |
Isoechoic | 10 (16.7) |
| |
Calcification | |
Microcalcification | 26 (43.3) |
Macrocalcification | 4 (6.7) |
Rim calcification | 0 |
Micro- and macrocalcification | 2 (3.3) |
| |
Margin, irregular or microlobulated | 46 (76.7) |
| |
Shape, taller-than-wide | 22 (36.7) |
Patient | Age, yr | Sex | Primary tumor size, cm | TNM stage |
Metastatic LNs | Background | US category |
Recur | Recurred area | RFS, mo |
---|---|---|---|---|---|---|---|---|---|---|
1 | 33 | M | 3.5 | T3N1aM0 | 29 | None | Intermediate | Yes | Lat. neck LNs | 6 |
2 | 21 | F | 1.1 | T1N1aM0 | 6 | HT | Intermediate | Yes | Lat. neck LNs | 51 |
3 | 32 | F | 2.0 | T3N1bM0 | 22 | HT | High | No | - | 88 |
4 | 26 | F | 0.9 | T1N1aM0 | 2 | HT | High | No | - | 67 |
Values are expressed as mean±standard deviation or number (%). LN, lymph node; RAI, radioiodine ablation.
ATA, American Thyroid Association.
TNM, tumor-node-metastasis; LN, lymph node; US, ultrasonography; RFS, recurrence-free survival; HT, Hashimoto’s thyroiditis; Lat., lateral. According to the 7th edition of the TNM staging system; According to the American Thyroid Association classification systems.