Endocrinol Metab > Volume 36(3); 2021 > Article |
|
T2DM, type 2 diabetes mellitus; IGF2, insulin-like growth factor 2; IFNL2, interferon lambda 2; IL, interleukin; NGF, nerve growth factor; BLK, BLK proto-oncogene; PROZ, protein Z; AFP, alpha-fetoprotein; ADAM2, ADAM metallopeptidase domain 2; CA15-3, carbohydrate antigen 15-3; PSG2, pregnancy specific beta-1-glycoprotein 2; CEA, carcinoembryonic antigen; CRP, C-reactive protein; FSHB, follicle stimulating hormone beta; TG, thyroglobulin; STAT6, signal transducer and activator of transcription 6.
Characteristic | Normoglycemia (n=71) | Prediabetes (n=35) | T2DM (n=36) | P value |
---|---|---|---|---|
Sex, male/female | 59/12 | 29/6 | 30/6 | 0.999 |
Hypertension | 9 | 6 | 10 | 0.152 |
Dyslipidemia | 0 | 3 | 19 | <0.001 |
CVD | 0 | 2 | 6 | 0.001 |
Smoking | 9 | 4 | 11 | 0.040 |
Alcohol | 40 | 18 | 13 | 0.139 |
Age, yr | 55.7±11.0 | 57.5±12.5 | 59.1±10.2 | 0.309 |
Height, cm | 167.04±7.67 | 166.40±9.09 | 165.14±7.71 | 0.519 |
Weight, kg | 62.96±7.01 | 64.15±8.20 | 63.90±8.14 | 0.702 |
BMI, kg/m2 | 22.69±1.48 | 23.22±1.24 | 23.30±1.80 | 0.079 |
Waist, cm | 79.86±6.42 | 82.75±5.18 | 86.60±6.81 | <0.001 |
SBP, mm Hg | 122.31±13.46 | 120.74±11.38 | 126.78±17.81 | 0.242 |
DBP, mm Hg | 78.41±9.18 | 73.09±8.51 | 75.83±12.71 | 0.017 |
WBC, 103/μL | 5.76±0.98a | 6.38±1.56 | 6.71±1.60 | 0.003 |
Hb, g/dL | 14.44±1.30b | 14.37±1.12 | 14.68±1.86 | 0.691 |
AST, U/L | 22.54±6.26 | 23.11±7.07 | 25.44±8.46 | 0.131 |
ALT, U/L | 18.32±8.19 | 22.03±8.96 | 25.83±11.78 | 0.001 |
Creatinine, mg/dL | 0.89±0.15 | 0.90±0.14 | 0.83±0.18 | 0.093 |
TG, mg/dL | 138.31±99.00 | 139.85±96.98 | 178.90±102.10 | 0.116 |
HDL, mg/dL | 51.03±14.01 | 53.78±12.43 | 44.77±10.19 | 0.010 |
LDL, mg/dL | 109.69±25.21 | 113.74±31.17 | 113.37±50.06 | 0.766 |
HbA1c, % | 5.29±0.20 | 5.93±0.20 | 7.29±1.49 | <0.001 |
FPG, mg/dL | 86.77±6.01 | 107.89±7.39 | 136.83±43.09 | <0.001 |
Insulin, μIU/mL | 2.09±1.37 | 5.45±3.48 | 7.75±5.68 | <0.001 |
HOMA-IR | 0.45±0.30 | 1.45±0.91 | 2.54±1.64 | <0.001 |
HOMA-β | 32.62±23.30 | 44.57±30.99 | 52.08±65.20 | 0.050 |
PROZ, pg/mL | 1,864.07±450.83 | 1,490.32±367.19 | 1,583.34±465.43 | <0.001 |
Values are expressed as number or mean±standard deviation. The definitions of smoking and alcohol are numbers of currently smoking and drinking in each group.
PROZ, protein Z; T2DM, type 2 diabetes mellitus; CVD, cardiovascular disease; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; WBC, white blood cell; Hb, hemoglobin; AST, aspartate aminotransferase; ALT, alanine aminotransferase; TG, triglyceride; HDL, high-density lipoprotein; LDL, low-density lipoprotein; HbA1c, hemoglobin A1c; FPG, fasting plasma glucose; HOMA-IR, homeostatic model assessment for insulin resistance; HOMA-β, homeostasis model assessment of β-cell function.
Yun-Ui Bae
https://orcid.org/0000-0002-5084-5293
Ji Hong You
https://orcid.org/0000-0003-1544-7094
Ho Chan Cho
https://orcid.org/0000-0003-0712-7728
Growth in Children with HLA-Conferred Susceptibility to Type 1 Diabetes2022 February;37(1)
Association of Vitamin D Deficiency with Diabetic Nephropathy2021 February;36(1)