Endocrinol Metab > Volume 25(1); 2010 > Article
Journal of Korean Endocrine Society 2010;25(1):56-60.
DOI: https://doi.org/10.3803/jkes.2010.25.1.56    Published online March 1, 2010.
Acromegaly with Diabetes Insipidus after Pituitary Tumor Removal: Successful Pregnancy and Delivery.
Sei Hyun Kim, Joo Il Kim, Yae Min Park, In Sik Won, Kwen Chul Shin, Yunjeong Jo, Sihoon Lee, Yeun Sun Kim, Ki Young Lee, Ie Byung Park
Department of Endocrinology and Metabolism, Gil Hospital, Gachon University of Medicine and Science, Korea.
A 33-year-old woman visited our hospital because of oligomenorrhea. Acromegaly was diagnosed based on elevated insulin like growth factor-I (IGF-I) and paradoxical growth hormone (GH) rise in oral glucose tolerance test. Pituitary macroadenoma was detected on magnetic resonance imaging (MRI). The pituitary tumor was removed. Still, diabetes insipidus developed. We prescribed desmopressin and bromocriptine. Two months post-surgery, IGF-I was decreased and a combined pituitary function test was normal, except for the follicle stimulating hormone response. Residual tumor was detected on MRI. The bromocriptine dose was increased and treatment with the long-acting somatostatin analogue octreotide long acting release (LAR) was begun. After the fifth round of octreotide LAR, IGF-I was normalized. After the seventh round of octreotide LAR, the patient became pregnant. Bromocriptine and octreotide LAR were stopped, and desmopressin was continued. Successful delivery occurred at week 38 of pregnancy. The patient was discharged without any complications. Acromegaly is a disease caused by chronic GH hypersecretion, generally related to a somatotroph adenoma. Amenorrhea and menstrual irregularities are common in acromegaly. Pregnancy rarely occurs because chronic anovulation usually exists. When gonadotroph axis was preserved, the possibility of pregnancy in a woman of child-bearing age with acromegaly should be considered.
Key Words: Acromegaly, Octreotide, Pregnancy

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