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Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
Copyright © 2018 Korean Endocrine Society
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.
AUTHOR CONTRIBUTIONS: Conception or design: P.T., L.G. Acquisition, analysis, or interpretation of data: P.T., L.G. Drafting the work or revising: P.T. Final approval of the manuscript: L.G.
Study | Country | Cut-off | MTC cases undergone ProCT evaluation during follow-up | REC | NED | ProCT sensitivity | ProCT specificity |
---|---|---|---|---|---|---|---|
Algeciras-Schimnich et al. (2009) [14] | USA | >0.15a | 133b | 43 | 42 | 97.7 | 100 |
Kaczka et al. (2010) [15] | Poland | >0.06 | 29 | 6 | 23 | 100 | 87 |
Walter et al. (2010) [17] | Switzerland-Netherlands | >0.06 | 69 | 69 | NA | 97.1 | NA |
Kratzsch et al. (2011) [18] | Germany | >0.06 | 10 | 10 | NA | 100 | NA |
Trimboli et al. (2018) [19] | Switzerland-Italy | >0.32a | 55 | 12 | 43 | 91.7 | 97.7 |
Total | 296 | 140 | 108 |
MTC, medullary thyroid carcinoma; ProCT, procalcitonin; REC, recurrent MTC; NED, no evidence of disease; NA, not available.
aReceiver operating characteristic derived cut-off; bThis group included 8 newly diagnosed MTC, 40 MTC with postoperative detectable and stable calcitonin levels (assessed as stable disease), and 43 MTC with proved structural disease (REC disease).
Study | Risk of bias | Feasibility | ||||||
---|---|---|---|---|---|---|---|---|
Patient selection | Study test | Reference standard | Timing | Patient selection | Study test | Reference standard | Timing | |
Algeciras-Schimnich et al. (2009) [14] | L | L | L | L | L | L | L | L |
Kaczka et al. (2010) [15] | L | U | U | H | H | L | L | L |
Walter et al. (2010) [17] | L | L | H | H | H | L | L | L |
Kratzsch et al. (2011) [18] | L | L | U | L | L | L | L | L |
Trimboli et al. (2018) [19] | L | U | U | L | L | L | L | L |