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1Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Philippine General Hospital, Manila, Philippines.
2Department of Pathology, Philippine General Hospital, Manila, Philippines.
Copyright © 2017 Korean Endocrine Society
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.
Characteristic | Philippines | USA [7] | Italy [6] | Japan [5] | Korea [11] | Taiwan [12] | Morocco [8] |
---|---|---|---|---|---|---|---|
Sample size | 18 | 91 | 183 | 29 | 49 | 67 | 7 |
Age at diagnosis, yr | 62.0 | 59.0 | 56.3 | 57.0 | 49.3 | 50.3 | 60.0 |
Female sex, % | 72.2 | 62.0 | 69.4 | 75.9 | 73.5 | 64.2 | 85.7 |
Criteria used for PDTC diagnosis | Turin criteria | Follicular cell differentiation+necrosis or mitotic index >5/10 HPF | TIS pattern | TIS pattern | TIS pattern+necrosis | TIS pattern | Turin criteria |
Predominant histology | Insular and trabecular | NR | Insular | Solid and trabecular | Solid and trabecular | NR | Insular |
Mean tumor size, cm | 5.8 | <4 | 5.3 | 3.1 | 4.7 | 4.2 | 4.0 |
Extrathyroidal extension, % | 44.4 | 30.0 | 54.0 | 55.2 | 59.0 | NR | 0 |
Lymph node metastasis, % | 27.8 | 40.7 | NR | 72.4 | 29.0 | NR | 57.1 |
Distant metastasis, % | 27.8 | 26.0 | NR | 13.8 | 33.0 | 49.3 | 0 |
Adjuvant RAI, % | 44.4 | 73.6 | 45.4 | NR | 78.0 | 67.2 | 100.0 |
5-Year survival rate, % | 83.3 | 62.0 | 85.0 | 89.3 | 69.4 | 62.7 | 85.0 |
Characteristic | WDTC [15] | PDTC | P value |
---|---|---|---|
Sample size | 0728 | 18 | - |
Age at diagnosis, yr | 44 (18–82) | 61 (40–75) | <0.001 |
Female sex, % | 85.9 | 72.2 | 0.051 |
Greatest tumor dimension, cm | 2.9 | 5.8 | <0.001 |
TNM stage on diagnosis, % | |||
Stage I | 58.4 | 5.6 | <0.001 |
Stage II | 13.2 | 5.6 | 0.172 |
Stage III | 13.1 | 27.8 | 0.035 |
Stage IV | 15.4 | 61.1 | <0.001 |
Lymph node metastasis, % | 18 | 27.8 | 0.144 |
Distant metastasis, % | 4.9 | 27.8 | <0.001 |
Treatment, % | |||
Initial surgery | 100 | 94.4 | |
Total thyroidectomy with neck dissection | 23.9 | 27.8 | 0.351 |
Total thyroidectomy only | 55.6 | 27.8 | 0.010 |
Near total thyroidectomy | 3.0 | 0 | 0.228 |
Subtotal thyroidectomy | 9.5 | 11.1 | 0.410 |
Lobectomy | 8.0 | 5.6 | 0.355 |
Tumor debulking with tracheostomy | 0 | 16.7 | <0.001 |
Tumor debulking only | 0 | 5.6 | <0.001 |
RAI | 71.8 | 44.4 | 0.339 |
EBRT | 2.1 | 0 | 0.267 |
Chemotherapy | 0.3 | 0 | 0.408 |
5-Year survival rate, % | 99.5 | 83.3 | <0.001 |
5-Year persistence and/or recurrence rate, % | 18.8 | 50.0 | 0.001 |
Characteristic | PDTC | ATC [19] | P value |
---|---|---|---|
Sample size | 18 | 15 | - |
Age, yr | 62 (40–75) | 63 (36–73) | 0.370 |
Female sex, % | 72.2 | 53.0 | 0.127 |
Greatest tumor dimension, cm | 5.8 | 10.0 | <0.001 |
Clinical presentation, % | |||
Goiter | 100.0 | 60.0 | 0.002 |
Hoarseness | 27.8 | 60.0 | 0.031 |
Dysphagia | 38.9 | 80.0 | 0.009 |
Difficulty of breathing | 38.9 | 60.0 | 0.114 |
Neck pain | 11.1 | 40.0 | 0.027 |
Weight loss | 22.2 | 60.0 | 0.014 |
Cough | 11.1 | 33.0 | 0.062 |
Lymph node metastasis, % | 27.8 | 73.0 | 0.005 |
Distant metastasis, % | 27.8 | 47.0 | 0.127 |
Treatment, % | |||
Surgery | 94.4 | 47.0 | 0.001 |
Curative | 72.2 | 20.0 | 0.001 |
Palliative | 22.2 | 26.7 | 0.382 |
RAI | 44.4 | 0 | <0.001 |
EBRT | 0 | 20.0 | 0.023 |
Chemotherapy | 0 | 0 | - |
5-Year survival rate, % | 83.3 | 0 | <0.001 |
Duration from diagnosis to death, mo | 12 | 3 | <0.001 |