Letter: The Effects of High Fat Diet and Resveratrol on Mitochondrial Activity of Brown Adipocytes (Endocrinol Metab 2016;31:328-35, Cheol Ryong Ku et al.)

Ji-Young Cha

doi:10.3803/EnM.2016.31.3.480

Articles

Page Path: HOME > Endocrinol Metab > Volume 31(3); 2016 > Article

Letter Letter: The Effects of High Fat Diet and Resveratrol on Mitochondrial Activity of Brown Adipocytes (Endocrinol Metab 2016;31:328-35, Cheol Ryong Ku et al.): Ji-Young Cha; Endocrinology and Metabolism 2016;31(3):480-481.
DOI: https://doi.org/10.3803/EnM.2016.31.3.480
Published online: September 26, 2016

Department of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine and Gachon Medical Research Institute, Gachon University Gil Medical Center, Incheon, Korea.

Corresponding author: Ji-Young Cha. Department of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, 155 Gaetbeol-ro, Yeonsu-gu, Incheon 21999, Korea. Tel: +82-32-899-6070, Fax: +82-32-899-6032, jycha1014@gachon.ac.kr

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

2,698 Views
25 Download

Full Article

Download PDF

Article information
References

Resveratrol (RSV) is a naturally occurring polyphenol that has been shown to have a wide range of biological activities, including phytoestrogenic, antioxidant, anti-inflammatory, anti-cancer, and anti-aging functions [1 2 3]. Several studies have proposed that RSV has beneficial effects on obesity and diabetes, such as decreased adipogenesis and viability in maturing preadipocytes, and increased lipolysis and decreased lipogenesis in mature adipocytes [2 4]. Treatment with RSV in mice ameliorated insulin resistance and increased resistance to cold [4]. The beneficial effects of RSV have been largely attributed to the ability of RSV to enhance energy expenditure by boosting mitochondrial function as a result of increased levels of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and uncoupling protein 1 (UCP-1) in skeletal muscles and brown adipose tissue (BAT) [4].

Recently, Ku et al. [5] demonstrated that RSV treatment improved insulin sensitivity in Otsuka Long Evans Tokushima Fatty (OLETF) rats which were fed either a standard chow diet (SD) or high fat diet (HFD). RSV treatment increased the number of brown adipocytes in both diet groups. However, the increased mitochondrial activity related to increased expression of UCP-1, phospho-adenosine monophosphate-activated protein kinase (phospho-AMPK), and estrogen receptor α (ER-α) was observed only in HFD-fed OLETF rats. These effects are consistent with the previous report from Lagouge et al. [4] which showed that RSV activates APMK and surtuin 1 in HFD-fed mice leading to activation of PGC-1α, and increased mitochondrial biogenesis. However, future studies are needed to address the mechanism of RSV on the mitochondrial activation of BAT and improved insulin sensitivity in SD-fed OLETF rats.

An interesting finding from this study was that RSV increases the expression of ER-α in the HFD group. RSV has been shown to act as a phytoestrogen and interact directly with ER-α and ER-β [6 7]. The phytoestrogenic action of RSV might depend on the distinctive expression patterns of ER-α and ER-β and the amplitude of this effect is also cell type specific. Therefore, more detailed investigations on the relationship between mitochondrial activity and ER-α would help elucidate the mechanisms underlying the beneficial effects of RSV on insulin sensitivity.

Article information

CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.

References

1. Kulkarni SS, Canto C. The molecular targets of resveratrol. Biochim Biophys Acta 2015;1852:1114–1123. Article PubMed
2. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006;444:337–342. Article PubMed PMC PDF
3. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 2006;5:493–506. Article PubMed PDF
4. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006;127:1109–1122. Article PubMed
5. Ku CR, Cho YH, Hong ZY, Lee H, Lee SJ, Hong SS, et al. The effects of high fat diet and resveratrol on mitochondrial activity of brown adipocytes. Endocrinol Metab (Seoul) 2016;31:328–335. Article PubMed PMC
6. Bowers JL, Tyulmenkov VV, Jernigan SC, Klinge CM. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta. Endocrinology 2000;141:3657–3667. Article PubMed PDF
7. Gehm BD, McAndrews JM, Chien PY, Jameson JL. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci U S A 1997;94:14138–14143. Article PubMed PMC

Figure & Data

References

Citations

Citations to this article as recorded by

PubReader
Cite

CITE

export Copy Format

Close

XML Download