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Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Copyright © 2016 Korean Endocrine Society
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.
Values are expressed as mean±SD.
CS, cholestyramine; T4, thyroxine; T3, triiodothyronine; TSH, thyroid stimulating hormone.
aTotally 12 g per day of cholestyramine were administrated; bP value for Mann-Whitney U test and chi-square test; cNormal range is 0.89 to 1.76 ng/dL; dNormal range is 0.6 to 1.81 ng/mL; eNormal range is 0.55 to 4.78 µIU/mL (lowest detectable values was 0.008 µIU/mL).
Variable | MZ+CSa (n=5) | MZ (n=12) | P valueb |
---|---|---|---|
Sex, female/male | 3/2 | 8/4 | 0.793 |
Age, yr | 34.2±18.0 | 41.9±14.4 | 0.225 |
Baseline | |||
Free T4, ng/dLc | 4.97±1.80 | 4.55±0.76 | 0.833 |
T3, ng/mLd | 5.09±1.81 | 4.28±1.14 | 0.170 |
TSH, µIU/mLe | 0.007±0.001 | 0.019±0.04 | 0.955 |
Four weeks after treatment | |||
Free T4, ng/dLc | 2.12±0.64 | 2.71±0.74 | 0.091 |
T3, ng/mLd | 1.80±0.69 | 2.19±0.79 | 0.370 |
TSH, µIU/mLe | 0.007±0.001 | 0.048±0.15 | 0.737 |
Average change in free T4 (Δ), ng/dLc | 2.85±1.44 | 1.84±0.91 | 0.399 |
Average change in T3 (Δ), ng/mLd | 3.28±1.41 | 2.08±0.81 | 0.058 |
Dose of methimazole, mg | 32.00±4.47 | 30±0.0 | 0.121 |
Described adverse events | 1/5 | 3/12 | |
Details | Pruritus (1) | Hepatitis (1) Pruritus (3) |
Values are expressed as mean±SD. CS, cholestyramine; T4, thyroxine; T3, triiodothyronine; TSH, thyroid stimulating hormone. aTotally 12 g per day of cholestyramine were administrated; b