Endocrinol Metab > Volume 27(4); 2012 > Article
Endocrinology and Metabolism 2012;27(4):268-273.
DOI: https://doi.org/10.3803/EnM.2012.27.4.268    Published online December 20, 2012.
Neuroendocrine Regulation of Energy Metabolism.
Marcelo O Dietrich, Tamas L Horvath
1Program on Cell and Neurobiology of Energy Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA. tamas.horvath@yale.edu
2Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
3Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
4Department of Neurobiology, Yale University School of Medicine, New Haven, CT, USA.
Abstract
Significant advancements have been made in the past century regarding the neuronal control of feeding behavior and energy expenditure. The effects and mechanisms of action of various peripheral metabolic signals on the brain have become clearer. Molecular and genetic tools for visualizing and manipulating individual components of brain homeostatic systems in combination with neuroanatomical, electrophysiological, behavioral, and pharmacological techniques have begun to elucidate the molecular and neuronal mechanisms of complex feeding behavior and energy expenditure. This review article highlights some of these advancements that have led to the current understanding of the brain's involvement in the acute and chronic regulation of energy homeostasis.
Key Words: Ghrelin, Glucose, Hunger, Hypothalamus, Leptin


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