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Response: Natural Course of Cytologically Benign Thyroid Nodules: Observation of Ultrasonographic Changes (Endocrinol Metab 2013;28:110-8, Dong Jun Lim et al.)
Dong Jun Lim, Ki Hyun Baek
Endocrinology and Metabolism 2013;28(3):243-244.
DOI: https://doi.org/10.3803/EnM.2013.28.3.243
Published online: September 13, 2013

Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.

Corresponding author: Ki Hyun Baek. Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, 10 63-ro, Yeongdeungpo-gu, Seoul 150-713, Korea. Tel: +82-2-3779-1400, Fax: +82-2-780-3132, drbkh@catholic.ac.kr

Copyright © 2013 Korean Endocrine Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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We have read Dr. Cho's letter regarding our article on the observation of ultrasonographic (US) changes in cytologically benign thyroid nodules [1] and are happy to respond to it.
We see many patients with benign nodules in daily clinical practice both before and after initial confirmation of benign cytology by fine needle aspiration (FNA), and usually follow-up with US. The most notable point is that, the more effort we invest in finding thyroid cancer in nodules, the more benign nodules were left behind in our clinics afterwards. One time benign cytologic results by FNA cannot be considered to safely eliminate the possibility of malignancy because false negativity is an inherent characteristic of FNA. Besides, it isn't clear whether or when we should perform repeat FNA on nodules with initially benign cytologic results. Therefore, a thorough understanding of the natural course of benign thyroid nodules is needed to establish an appropriate follow-up scheme. In this sense, our study showed US changes of benign nodules with suspicious features over a short-term period.
Partially concordant with our results, one article by Kwak et al. [2] indicated that repeat FNA of thyroid nodules with initial benign cytology is valuable only in growing nodules with suspicious US features, not in completely benign-appearing nodules. A more recent paper suggested that long-term follow-up of patients with cytologically-confirmed benign nodules is asassociated with increased repeat FNA and US without improvement in the malignancy detection rate, discouraging unlimited follow-up of benign nodules [3]. Derived from the above viewpoints, follow-up procedures for nodules with suspicious US features should be different from benign-looking nodules without suspicious US features, whether this includes more US or repeat FNA. However, this kind of protocol should be validated first with a long-term, well-designed prospective study.
Regarding the question of the age factor in our study raised by Dr Cho, the fact that younger age is associated with nodule growth in women may be more supported by the recent basic research of Xu et al. [4]. Our study used a more than 50% increase in nodule volume as a cut off, which varied from previous studies and might widen the differences of the effects of younger and older ages on nodule growth.

No potential conflict of interest relevant to this article was reported.

  • 1. Lim DJ, Kim JY, Baek KH, Kim MK, Park WC, Lee JM, Kang MI, Cha BY. Natural course of cytologically benign thyroid nodules: observation of ultrasonographic changes. Endocrinol Metab 2013;28:110–118.Article
  • 2. Kwak JY, Koo H, Youk JH, Kim MJ, Moon HJ, Son EJ, Kim EK. Value of US correlation of a thyroid nodule with initially benign cytologic results. Radiology 2010;254:292–300. ArticlePubMed
  • 3. Lee S, Skelton TS, Zheng F, Schwartz KA, Perrier ND, Lee JE, Bassett RL, Ahmed S, Krishnamurthy S, Busaidy NL, Grubbs EG. The biopsy-proven benign thyroid nodule: is long-term follow-up necessary? J Am Coll Surg 2013;217:81–88. ArticlePubMed
  • 4. Xu S, Chen G, Peng W, Renko K, Derwahl M. Oestrogen action on thyroid progenitor cells: relevant for the pathogenesis of thyroid nodules? J Endocrinol 2013;218:125–133. ArticlePubMed

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    • Calcification Patterns in Papillary Thyroid Carcinoma are Associated with Changes in Thyroid Hormones and Coronary Artery Calcification
      Jeonghoon Ha, Jeongmin Lee, Kwanhoon Jo, Jeong-Sun Han, Min-Hee Kim, Chan Jung, Moo Kang, Bong Cha, Dong-Jun Lim
      Journal of Clinical Medicine.2018; 7(8): 183.     CrossRef

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