Endocrinol Metab > Volume 27(4); 2012 > Article
Endocrinology and Metabolism 2012;27(4):276-281.
DOI: https://doi.org/10.3803/EnM.2012.27.4.276    Published online December 20, 2012.
APOA5 Polymorphism Is Associated with Metabolic Syndrome in Korean Postmenopausal Women.
Doh Hee Kim, Seung Hee Lee, Kyung Hoon Han, Chae Bong Kim, Kwan Young Song, Sook Cho, Kye Heui Lee
1Research Institute, Seoul Medical Center, Seoul, Korea.
2Department of Neurosurgery, Seoul Medical Center, Seoul, Korea.
3Department of Obstetrics and Gynecology, Seoul Medical Center, Seoul, Korea.
4Department of Internal Medicine, Seoul Medical Center, Seoul, Korea. people@chol.com
Abstract
BACKGROUND
Menopause is an independent risk factor in metabolic syndrome which induced an alteration of the lipid metabolism by hormonal changes. Apolipoprotein A5 gene (APOA5) was related to the regulation of triglyceride and high density lipoprotein cholesterol (HDL-C) level with biosynthesis and decomposition. This study was conducted to investigate the relationship between APOA5 polymorphism and metabolic syndrome in Korean postmenopausal women. METHODS: This study included 307 postmenopausal women with anthropometric and biochemical measurement in 2010-2011. The polymorphism of APOA5 was analyzed by polymerase chain reaction-restriction fragment length polymorphism method with MseI restriction enzyme. RESULTS: The metabolic syndrome prevalence with TT genotype was significantly lower than the frequency in those with TC/CC (27.09%, 38.46%, and 45.71% for TT, TC, and CC, respectively; P < 0.05). Multiple regression analysis of metabolic syndrome risk factors indicated that postmenopausal women with CC genotype had a higher risk with 3 times than that in TT genotype (P < 0.05). APOA5 C carriers showed an increased risk of triglyceride level (odd ratio, 2.93 and 1.85 for CC and TC+CC, respectively; P < 0.05). Interestingly, HDL-C was related to triglyceride directly in comparison to APOA5. CONCLUSION: The results of this study indicate that APOA5 has an influence on serum triglyceride and HDL-C, which contribute to metabolic syndrome in Korean postmenopausal women.
Key Words: Apolipoproteins A, HDL cholesterol, Metabolic syndrome X, Single nucleotide polymorphism, Triglycerides


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