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Endocrinol Metab : Endocrinology and Metabolism



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Case Report A Case of Focal Type Nesidioblastosis in Adult Treated with Distal Pancreatectomy.
Dae Gyu Seo, Wang Sik Shin, Gil Sung Han, Jae Gun Jung, Ho Sang Shon, Ki Sung Ahn, Hoon Kyu Oh, Jae bok Park, Young Jin Kim
Endocrinology and Metabolism 1994;10(2):136-141

Published online: November 6, 2019
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Nesidioblastosis, the process of differentiation of pancreatic islets from ductular epithelium, is a frequent cause of hyperinsulinemic hypoglycemia in neonates and infants, but rare in adults. A 38-year-old man had suffered from intermittent hypoglycemic symtoms for 10 years. He had inappropriately elevated plasma immunoreactive insulin level and I/G ratio during a prolonged fast. There was no evidence of tumor on the abdominal CT scan and operation although celiac angiography showed a round mass like lesion in the distal pancreatic area.His hypoglycemic symptoms were improved by distal pancreatectomy.Pathologic finding in the resected pancreas was that of focal type nesidioblastosis I.e, increased size and number of islets with scattered numerous small islets around ductules in focal lesion. Distal pancreatectomy as an initial operation may be effective in the treatment of focal type nesidioblastosis.

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