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Endocrinol Metab : Endocrinology and Metabolism



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Original Article Changes of Interleutin-6 Level Ofter Treatment of Radioactive Iodine in Graves' Disease.
Keun Yong Park
Endocrinology and Metabolism 1994;10(3):214-219

Published online: November 6, 2019
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Interleukin-6(IL-6) is a cytokine secreted from lymphocytes or non-lymphoid cell(monocyte, fibroblast, osteoblast, vascular endothelial cell, or synoviocytes). Increased serum IL-6 concentrations have recently been reported in patients with subacute thyroiditis, possibly because of cytokine release damaged thyroid cells. In this study, IL-6 levels serum T_3, T_4, Thyroglobulin(Tg) and TSH were determined by an radioimmunoassay method in 14 patients treated with radioactive iodine(10mci) for Graves' disease. IL-6 levels were as follows: 23.9+-0.8 fmol/ml(at baseline), 25.4+-1.1 fmol/ml(1hour), 24.7+-0.6 fmol/ml(24hours), 76.8+-2.0 fmol/ml(48hours), 22.8+-0.5 fmol/ml(72hours). There was significant increase in IL-6 values at 48hours after RAI treatment(p<0.01). Serum Tg, T_3 and T_4 also increased after RAI treatment, but no significant correlation could be demonstrated with the increase in L-6. The results of this study support the concept that IL-6 can be regarded as a useful marker of thyroid-destructive processes.

Endocrinol Metab : Endocrinology and Metabolism