Journal of Korean Endocrine Society 1996;11(2):240-246.
Published online November 7, 2019.
Two Cases of hypoglycemia in IDDM patients with insulin antibody.
G A Kim, K W Lee, M R Kim, Y J Kim, J N Jang, S K Bae, B G Son
Hirata et al. first described the association of insulin antibodies with hypoglycemia attacks and decreased glucose tolerance in a patient who had not previously received insulin injections. Since that time there have been additional reports in the Japanese literature. Insulin antibodies are present in most of the patients who received insulin for a period of time, usually exceeding six weeks. There were several reports of hypoglycemia in patients with non-insulin-dependent diabetes mellitus who had developed insulin antibody after insulin administration and also in patients with insulin dependent diabetes mellitus. It is well known that either insulin antibody to the lower affinity site or insulin receptor antibody can be a eause of hypoglycemia. Recently, we experienced two cases of hypoglycemia in patient with insulin dependent diabetes rnellitus and non- insulin- dependent diabetes mellitus who had developed insulin antibody after insulin administration. Hereby we present these cases with review of the literature.
Key Words: Hypoglycemia, Insulin antibody, NIDDM

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