Immunoglobulin G4-Related Thyroid Disease: A Single-Center Experience and Literature Review

Meihua Jin; Bictdeun Kim; Ahreum Jang; Min Ji Jeon; Young Jun Choi; Yu-Mi Lee; Dong Eun Song; Won Gu Kim

doi:10.3803/EnM.2021.1318

Endocrinol Metab > Volume 37(2); 2022 > Article

Jin, Kim, Jang, Jeon, Choi, Lee, Song, and Kim: Immunoglobulin G4-Related Thyroid Disease: A Single-Center Experience and Literature Review

Original Article

Thyroid

Endocrinology and Metabolism 2022;37(2):312-322.

Published online: April 25, 2022

DOI: https://doi.org/10.3803/EnM.2021.1318

Immunoglobulin G4-Related Thyroid Disease: A Single-Center Experience and Literature Review

Keypoint

Immunoglobulin G4 (IgG4)-related disease is an entity that can involve the thyroid gland. The authors retrospectively reviewed the clinical presentation and the radiological and pathological findings of 5 patients diagnosed with IgG4-related thyroid disease at a single tertiary medical center in Korea. In conclusion, biopsy with IgG4 immunostaining and serum IgG4 measurements may be helpful in diagnosing patients suspected of having IgG4-related thyroid disease.

Meihua Jin¹

, Bictdeun Kim¹, Ahreum Jang¹, Min Ji Jeon¹, Young Jun Choi², Yu-Mi Lee³, Dong Eun Song⁴, Won Gu Kim¹

¹Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

²Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

³Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

⁴Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Corresponding author: Won Gu Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea
Tel: +82-2-3010-5883, Fax: +82-2-3010-6962, E-mail: wongukim@amc.seoul.kr

Received November 1, 2021 Revised February 8, 2022 Accepted February 17, 2022

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

Immunoglobulin G4 (IgG4)-related disease is an entity that can involve the thyroid gland. The spectrum of IgG4-related thyroid disease (IgG4-RTD) includes Hashimoto thyroiditis (HT) and its fibrotic variant, Riedel thyroiditis, as well as Graves’ disease. The early diagnosis of IgG4-RTD is important because it is a medically treatable disease, and a delay in the diagnosis might result in unnecessary surgery. We present a case series of IgG4-RTD with a review of the literature.

Methods

We retrospectively reviewed the clinical presentation and the radiological and pathological findings of patients diagnosed with IgG4-RTD between 2017 and 2021 at a tertiary medical center in Korea. We also conducted a literature review of IgG4-RTD.

Results

Five patients were diagnosed with IgG4-RTD during the study period. The patients’ age ranged from 31 to 76 years, and three patients were men. Most patients visited the clinic for a neck mass, and hypoechogenic nodular lesions were observed on neck ultrasonography. Three patients had IgG4 HT, and two patients had IgG4 Riedel thyroiditis. All patients developed hypothyroidism that necessitated L-thyroxine replacement. The diagnosis of IgG4-RTD was confirmed after a pathological examination of the surgical specimen in the first two cases. However, the early diagnosis was possible after a core needle biopsy in three clinically suspected patients.

Conclusion

The diagnosis of IgG4-RTD requires clinical suspicion combined with serology and histological analyses using IgG4 immunostaining. The early diagnosis of IgG4-RTD is difficult; thus, biopsy with IgG4 immunostaining and serum IgG4 measurements will help diagnose patients suspected of having IgG4-RTD.

Keywords: Immunoglobulin G4; Thyroid diseases; Hashimoto disease; Riedel thyroiditis; Graves disease

INTRODUCTION

Immunoglobulin G4 (IgG4)-related disease, a disease entity involving multiple organs, is characterized by dense lymphoplasmacytic infiltration of IgG4-positive plasma cells in various involved tissues [1-3]. Since autoimmune pancreatitis was reported in 2001, similar fibro-inflammatory diseases such as Mikulicz syndrome, retroperitoneal fibrosis, Kűttner tumor, and Riedel thyroiditis (RT) have been unified under the unique spectrum of IgG4-related disease [1,3-7]. It is typically characterized by elevated serum IgG4 levels and a good response to steroid therapy [2,8]. Thyroid gland involvement in IgG4-related disease was suggested based on the frequent observation of hypothyroidism and thyroid autoantibodies in patients with autoimmune pancreatitis [9,10].

A unique subgroup of Hashimoto thyroiditis (HT) with increased IgG4-positive plasma cells in the thyroid tissue was first reported in 2009 [11]. Since then, the identification of other subtypes of IgG4-rich thyroid conditions has been reported. This expanding spectrum of IgG4-related thyroid disease (IgG4-RTD) now includes HT and its fibrotic variant (FVHT), RT, and Graves’ disease (GD) [8]. The pathogenesis of IgG4-RTD involves genetic factors, antigen-antibody reactions, and allergic phenomena, but remains poorly understood [2,12]. Due to insufficient awareness of this clinical entity, the prevalence of IgG4-RTD is likely to be underestimated. Most studies regarding IgG4 HT were reported in Japan, with the remainder in China and Germany [13-16].

IgG4-RTD is a medically treatable disease in the vast majority of cases. Nonetheless, rapid progression of the disease and a delayed diagnosis might result in unnecessary surgery. Despite its clinical importance, there have been only a few case reports of IgG4-RTD, including RT, in Korea [17-19]. IgG4 immunostaining data were insufficient in these reports, and the diagnosis was confirmed after total thyroidectomy. In some recent cases, we have diagnosed IgG4-RTD by core needle biopsy (CNB) before surgery. Therefore, we report a case series of IgG4-RTD from a single institution and present a literature review of IgG4-RTD focusing on IgG4-related HT.

METHODS

Patients

We retrospectively reviewed the medical records of five patients diagnosed with IgG4-related thyroiditis between 2017 and 2021 at a tertiary medical center in Korea. For each case, clinical presentation, radiology, pathology, treatment, and clinical outcomes were described in detail. This study was approved by the Institutional Review Board of Asan Medical Center (No. 2021-0867). The requirement of informed consent from the patients was waived due to the retrospective study design.

Laboratory measurement and histological evaluation

The reference ranges of thyroid-stimulating hormone (TSH) and free thyroxine (fT4) were 0.4 to 4.5 mIU/L and 0.80 to 1.90 mg/dL, respectively. The anti-thyroid peroxidase antibody (TPOAb) level was determined by radioimmunoassay (BRAHMS anti-TPOn RIA, Thermo Fisher, Waltham, MA, USA), and a value of ≥60 U/mL was considered positive. The anti-thyroglobulin antibody (TgAb) level was also measured by radioimmunoassay (BRAHMS anti-Tgn RIA), and a value of ≥60 U/mL was considered positive [20]. Serum IgG was measured using nephelometry (nephelometer, Dade Behring, Siemens, Munich, Germany) and IgG4 using a single radial immunodiffusion method (The Binding Site, Birmingham, UK) [21]. A serum IgG4 level ≥135 mg/dL was considered to indicate positivity [2,22]. An experienced endocrine pathologist (D.E.S.) reviewed all the specimens and confirmed the diagnosis of IgG4-RTD. The histological criteria for diagnosis of IgG4-thyroiditis were as follows: ≥20 IgG4-positive plasma cells/high power field (HPF) and an IgG4/IgG ratio >30% [13]. The diagnosis of IgG4-RTD was categorized as definite, probable, or possible based on the recently updated criteria of IgG4-RTD [22].

Literature review

We performed a literature review using the keywords “IgG4,” “thyroid,” “Hashimoto,” “Riedel’s thyroiditis,” and “Graves’ disease” in the PubMed database. We also found related studies by referring to several recent reviews [8,23-25]. We identified nine studies on IgG4-related HT, one study on FVHT, 10 studies on IgG4-related RT, and eight studies on IgG4-related GD. Each spectrum of disease was briefly summarized.

CNB-based pathology revealed a dense sclerotic inflammatory lesion with increased IgG4-positive cells (up to 54 cells/HPF) with an IgG4/IgG ratio of 21%, suggesting IgG4-related HT (Fig. 2M-O).

Treatment and clinical outcome

The serum IgG4 level had increased to 1,070 mg/dL, with multiple enlarged mesenteric lymph nodes on abdominal-pelvic CT, necessitating follow-up. She is being treated with L-thyroxine and followed with neck US, and is under consideration for steroid treatment in case of deterioration.

DISCUSSION

IgG4-related HT

We presented three cases (cases 1, 3, and 5) of IgG4-related HT in this study. Autoantibodies and serum IgG4 had increased in two patients (cases 1 and 5). One patient underwent total thyroidectomy for progressive goiter, and two patients were being treated with L-thyroxine and closely followed up. We found nine studies in the literature on IgG4-related HT from several countries (Table 2) [11,13-16,26-29]. Most of the early research began in Japan, and the authors proposed the new term “IgG4 thyroiditis” [11,13,26]. Based on the immunohistochemical staining pattern for IgG4 on surgical pathology, IgG4 thyroiditis can be sub-classified as distinct from HT, with a more severe lymphoplasmacytic infiltration, dense fibrosis, and marked follicular cell degeneration [11]. In 2012, the same group performed a larger study including 105 patients with HT; 28 had IgG4 thyroiditis and 77 had non-IgG4 thyroiditis [13]. They extended the previous histopathological findings by describing the pattern of stromal fibrosis. IgG4 thyroiditis was significantly associated with the presence of predominant interfollicular fibrosis, whereas non-IgG4 thyroiditis was characterized by predominant interlobular fibrosis [13]. The prevalence of IgG4 thyroiditis in all HT patients ranged from 12.6% to 38.5% in several studies using surgical specimen databases. The discrepancies between Europe and Asia might be explained by genetic, dietary, and geographic differences [23]. Furthermore, one reason might be the histological criteria for the diagnosis of IgG4 thyroiditis [8,15]. In contrast to these studies, which used surgical specimens as the data source, two studies that screened serum total IgG levels in patients with HT diagnosed with IgG4 thyroiditis based on the serum criterion (IgG4 >135 mg/dL) showed lower prevalence (4.0% to 5.3%) [27,28,30]. In these two studies using serological databases, five and six patients were diagnosed with IgG4 thyroiditis, one and two of whom were confirmed by biopsy, respectively [27,28].

Since IgG4 thyroiditis began to emerge as a new clinicopathological entity, subsequent studies were reported to investigate the further meaning of this sub-classification, including the serum IgG4 level. Unlike the earlier study by Li et al. [26], Zhang et al. [16], and Raess et al. [29] reported that there were no significant differences in serum total IgG and IgG4 levels between the IgG4 thyroiditis and non-IgG4 thyroiditis groups. Furthermore, other studies reported that only 4.0% to 5.3% of patients with HT were diagnosed with IgG4 thyroiditis based on the serum criterion [2,27,28]. These findings suggest that serum IgG and IgG4 levels were neither necessary nor adequate for the diagnosis of IgG4 thyroiditis. If additional criteria are met, “probable” IgG4-RTD can be diagnosed without serum IgG4 elevation according to the latest diagnostic criteria [22]. This is also supported by our study, which showed that serum IgG4 levels were elevated in two of three patients. However, the levels of IgG4 binding to specific thyroid antigens, such as TPOAb and TgAb, were significantly higher in the IgG4 thyroiditis group [16]. Thus, these markers, including TPOAb IgG4 and TgAb IgG4, might be helpful for differentiating the diagnosis.

In addition to histopathological findings, Li et al. [26] reported distinct clinical and ultrasonographic features between IgG4 thyroiditis and non-IgG4 thyroiditis. Compared with patients with non-IgG4 thyroiditis, patients with IgG4 thyroiditis were more likely to be younger and male, and showed more rapid progress, more subclinical hypothyroidism than euthyroidism, more diffuse low echogenicity, and higher levels of circulating antibodies [26]. These clinical features had some degree of discrepancy in other studies. In terms of age, Zhang et al. [16] and Jokisch et al. [15] also reported that patients with IgG4 thyroiditis were significantly younger than patients with non-IgG4 thyroiditis. However, this was not confirmed in the study by Takeshima et al. [28]. This may have resulted from the low prevalence of disease and regional differences. In general, according to previous studies, the mean age of patients with IgG4 thyroiditis was 42 to 74 years, with middle-aged men being typically affected (Table 2). Although a lower female-to-male ratio is a well-established finding in IgG4-related HT compared to non-IgG4 thyroiditis, 50% to 100% of patients diagnosed with IgG4 thyroiditis were women (Table 2). Despite its small numbers, our study revealed a comparable patient profile.

Fibrous variant of HT

FVHT is a rare form of HT, accounting for 10% of patients with HT [31]. The main histopathological feature of FVHT is marked fibrous replacement of more than one-third of the thyroid parenchyma [31]. Thus, it is characterized by severe constrictive symptoms and a very firm thyroid gland with rapid enlargement. Deshpande et al. [32] first proposed that FVHT belongs to the spectrum of IgG4-RTD in 2012. These authors evaluated 28 cases of HT and nine cases of FVHT and found that compared to typical HT, FVHT showed a significantly higher IgG4-positive cell count, IgG4/IgG ratio, and hypothyroidism. The median age of the nine patients was 50 years, and one of them was male. Due to the rarity of the disease and the small numbers of the current study, we were unable to present an FVHT case in this study. More research is needed in the future.

IgG4-related RT

RT is a rare form of chronic thyroiditis that characteristically extends through surrounding tissues with a prevalence of 1.06 cases per 100,000 patients [33]. Although the precise etiology of this disease remains unknown, in some cases it has been considered as the thyroid manifestation of multifocal fibrosis in combination with other fibrotic disorders. In 2010, Dahlgren et al. [7] reported surplus IgG4 plasma cells in three cases of RT surgical specimens, and they suggested that RT was a part of the IgG4-related systemic disease spectrum. A few case studies have evaluated RT in the literature, including a recent systematic review, as briefly presented in Table 3 [7,24,34-40]. The mean age of the 24 patients was 42 years (range, 21 to 81) and most (78.9%) were women (Table 3). Typically, hypothyroidism is not described in RT, and only 33% of the patients had hypothyroidism. We presented two cases (case 2 and 4) of IgG4-related RT in this study. Both of these patients were men and developed hypothyroidism. As RT is a rare disease, there have been neither treatment guidelines nor large prospective studies. Based on these studies, multiple treatment approaches for RT, including systemic steroids, tamoxifen, and thyroidectomy have been used [39]. Glucocorticoids are still the mainstay of therapy, and surgical management is administered when a histopathological diagnostic confirmation is needed or when acute compressive symptoms exist. In the current case series, one patient underwent total thyroidectomy to rule out malignancy; however, the other one is being followed up with thyroid function tests and US without steroid treatment or surgery. Additionally, IgG4-related RT was linked with other fibrosclerotic diseases; thus, a systemic work-up for other organs is important.

Both FVHT and RT are characterized by destruction of the thyroid architecture by stromal fibrosis, which blurs the differential diagnosis. Most importantly, FVHT is typically limited to the thyroid without extracapsular extension, unlike RT [8,41]. RT is also associated with lower thyroid antibody titers, the more frequent presence of autoimmune disease, and diminished Doppler flow on US compared to FVHT [2,41].

IgG4-related GD

Since the first case of a patient with GD whose histological and serological findings indicated IgG4-RTD, studies on the relationship between GD and IgG4 have been actively conducted [42]. A subset of patients with GD have elevated serum IgG4 levels, which have been reported to be associated with thyroid eye disease (TED). As summarized in Table 4, the prevalence of elevated serum IgG4 ranges from 6.4% to 23.1% [25,43-50]. These patients were older at diagnosis and responded excellently to anti-thyroid drug therapy [23,43,46]. These studies reported that the prevalence of TED in patients with IgG4-related GD was as high as 37.5% to 100%. Furthermore, Yu et al. [48] reported that serum IgG4 levels were associated with the severity of TED. However, these studies focused on the relationship between serum IgG4 and GD, rather than histological confirmation, and the criteria for serum IgG4 elevation were varied. Therefore, the role of IgG4 in GD needs to be validated in the future. As with FVHT, we were unable to include IgG4-related GD patients in this study.

Diagnosis of IgG4-RTD

IgG4-RTD includes a heterogeneous spectrum of disease features; therefore, the approach to treating this disease may be complex. The recently proposed criteria by the Japan Endocrine Society comprise five items: (1) enlargement of the thyroid, (2) hypoechoic lesions in the thyroid evidenced by US, (3) elevated serum IgG4 levels, (4) histopathological findings in the thyroid lesion, and (5) the involvement of other organs [22]. The diagnosis is categorized as “definitive,” “probable,” or “possible” based on the degree to which the above five items are present.

Because histological features are the mainstay of the diagnosis, physicians’ decision to perform a biopsy with additional IgG4 immunostaining is most important for the early diagnosis of IgG4-RTD. Based on our experience and the literature review, enlargement of the thyroid lobe with hypoechoic lesions on US and combined thyroid dysfunction might be important factors. In our study, we did not diagnose the first two patients with IgG4-RTD by CNB because we did not perform IgG4 immunostaining. However, we performed CNB with immunostaining of IgG4 in the three more recent clinically suspected cases. Because IgG4-RTD is a medically treatable disease, an early diagnosis might reduce unnecessary surgery and subsequent complications.

Another issue is the technique of performing CNB in IgG4-RTD. The lesion in IgG4-RTD is particularly hard; thus, inserting the core needle into the lesion is challenging and needs caution. When the stylet of the core needle and the cutting cannula are fired, the needle recoils. The recoil must be minimized to collect an accurate sample and to minimize damage to the surrounding structures.

It is currently impossible to assess the prevalence of IgG4-RTD in Korea, because only a few cases have recently begun to be diagnosed. In addition, the treatment of patients (three out of five) in this study was not substantially different from the existing treatment of non-IgG4-RTD. However, it cannot be assumed that the findings are of little clinical significance for these reasons. Due to a lack of awareness and suspicion of this disease, IgG4-RTD might be underdiagnosed. In this study, two patients underwent surgery before the diagnosis of IgG4-RTD, and three cases were diagnosed in a single year thereafter. Therefore, we expect awareness and suspicion of this disease entity will lead to more diagnoses and an improved understanding of the disease. Furthermore, the prognosis and treatment will be evaluated accurately through longer follow-up.

Conclusion

This study describes the first case series of IgG4-RTD in Korea and reviews the current knowledge of IgG4-RTD. The early diagnosis of IgG4-RTD requires clinical features combined with serology and histological features with IgG4 immunostaining. We expect further research that will lead to a deeper understanding of IgG4-RTD in Korea.

NOTES

CONFLICTS OF INTEREST

No potential conflict of interest relevant to this article was reported.

AUTHOR CONTRIBUTIONS

Conception or design: W.G.K. Acquisition, analysis, or interpretation of data: M.J., B.K., A.J., M.J.J., Y.J.C, Y.M.L., D.E.S. Drafting the work or revising: M.J., B.K., D.E.S., W.G.K. Final approval of the manuscript: D.E.S., W.G.K.

Acknowledgments

This study was supported by a grant (2021IL0039) from the Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.

A part of this study was presented as poster at the Ninth Seoul International Congress of Endocrinology and Metabolism, 2021.

Fig. 1.

Initial thyroid ultrasonography showing heterogeneously decreased parenchymal echogenicity without a focal nodular lesion: transverse view (A), longitudinal view (B). Neck computed tomography showing diffuse enlarged and heterogeneous attenuation of the bilateral thyroid glands: transverse view (C), coronal view (D). Core needle biopsy showing dense interlobar stromal fibrosis and atrophy of thyroid follicles (E, F: H&E stain, ×100). Gross pathology of an enlarged thyroid gland with a weight of 135 g (G). Surgical pathology showing dense lymphoplasmacytic infiltration (H, I: H&E stain, ×200). Immunoglobulin G4 (IgG4) immunohistochemistry revealing diffuse infiltration of IgG4-positive plasma cells (J: IgG4 stain, ×200).

Fig. 2.

Thyroid ultrasonography (US) shows a solid, irregular-shaped hypoechoic mass: transverse view (A), longitudinal view (B). Core needle biopsy (CNB) revealing interfollicular fibrosis (C: H&E stain, ×100), dense lymphoplasmacytic infiltration (D: H&E stain, ×200), and immunoglobulin G4 (IgG4)-positive plasma cells increased up to 63/high power fields (E: IgG4 stain, ×200). Thyroid US showing an irregular-shaped hypoechoic nodule with macrocalcification: transverse view (F), longitudinal view (G). Dense interlobar stromal fibrosis and atrophy of thyroid follicles are identified on CNB (H: H&E stain, ×100). In addition, there is substantial IgG4-positive plasma cell infiltration with the destruction of thyroid follicles in the CNB specimen (I: H&E stain, ×200; J: IgG4 stain, ×200). Thyroid US showing a solid, irregular-shaped hypoechoic lesion: transverse view (K), longitudinal view (L). CNB reveals a dense sclerotic inflammatory lesion (M: H&E stain, ×100; N: H&E stain, ×200) with IgG4-positive plasma cells (O: IgG4 stain, ×200).

Table 1.

Clinical Characteristics of the Six Patients with IgG4-RTD

	Age, yr	Sex	Year	IgG4-RTD diagnosis	Pathology subtype	Initial presentation	Transient thyrotoxicosis	Thyroid function	TPOAb, U/mL	TgAb, U/mL	Serum IgG4, mg/dL	CNB diagnosis	IgG4 plasma cell, /HPF	IgG4/IgG ratio, %	Surgery
1	31	M	2017	Definite	Hashimoto thyroiditis	Neck mass	-	SCH	3,000	2,000	171	-	152	55	+
2	41	M	2018	Probable	Riedel thyroiditis	Neck mass	-	Hypo	3,000	2,000	NA	-	93	42	+
3	76	F	2021	Probable	Hashimoto thyroiditis	Neck mass	+	Hypo	7.5	56.2	107	+	63	35	-
4	72	M	2021	Probable	Riedel thyroiditis	Thyroid nodule	+	Hypo	20.2	85.5	91	+	75	37	-
5	66	F	2021	Possible	Hashimoto thyroiditis	General weakness	-	SCH	711	2,000	1,070	+	54	21	-

IgG4-RTD, immunoglobulin G4-related thyroid disease; TPOAb, anti-thyroid peroxidase antibody; TgAb, antithyroglobulin antibody; IgG4, immunoglobulin G4; CNB, core needle biopsy; HPF, high power field; SCH, subclinical hypothyroidism; Hypo, hypothyroidism; NA, not available.

Table 2.

Summary of Previously Reported Cases of IgG4 Hashimoto Thyroiditis

Study	Year	Country	Study design	Data source	Prevalence (IgG4 thyroiditis/total HT)	Sex, F/M (F proportion)	Age, yr
Li et al. [11]	2009	Japan	Retrospective	Surgical specimens	5/13 (38.5)	4/1 (80)	56±19
Li et al. [26]	2010	Japan	Retrospective	Surgical specimens	19/70 (27.1)	14/5 (73.7)	53±10
Li et al. [13]	2012	Japan	Retrospective	Surgical specimens	28/105 (27.7)	21/7 (75)	52±10
Zhang et al. [16]	2014	China	Retrospective	Surgical specimens	12/53 (22.6)	11/1 (91.7)	43±19
Kawashima et al. [27]	2014	Japan	Prospective	Serological data	5/94 (5.3)	5/0 (100)	58±15
Takeshima et al. [28]	2015	Japan	Prospective	Serological data	6/149 (4.0)	3/3 (50)	74±7
Raess et al. [29]	2015	USA	Retrospective	Surgical specimens	8/23 (34.8)	NA	NA
Jokisch et al. [15]	2016	Germany	Retrospective	Surgical specimens	24/191 (12.6)	11/1 (91.7)	42±15
Zhao et al. [14]	2018	Singapore	Case report	Surgical specimens	-	1/0 (100)	47

Values are expressed as number (%) or mean±standard deviation.

IgG4, immunoglobulin G4; HT, Hashimoto thyroiditis; NA, not available.

Table 3.

Summary of Previously Reported Cases of IgG4-Related Riedel Thyroiditis

Study	Year	Country	No. of cases	Sex, F/M (F proportion)	Age, yr	Hypothyroidism	Glucocorticoid/thyroidectomy
Dahlgren et al. [7]	2010	USA	3	3/0 (100)	39, 43, 37	2	1/2
Pusztaszeri et al. [34]	2012	Switzerland	1	1/0 (100)	57	0	0/1
Camerselle-Teijeiro et al. [35]	2014	Spain	1	1/0 (100)	39	0	0/1
Takeshima et al. [36]	2015	Japan	2	1/1 (50)	31, 27	0	1/1
Lee et al. [17]	2016	Korea	1	1/0 (100)	35	1	1/1^a
Stan et al. [37]	2017	USA	5^b	NA	NA	NA	0/5
Simoes et al. [38]	2018	Brazil	1	1/0 (100)	40	1	1/0
Falhammar et al. [39]	2018	Sweden	3^c	2/1 (66.7)	81, 35, 25	2	2/1^a
Blanco et al. [40]	2019	Colombia	2	1/1 (50)	38, 56	1	0/2
Yu et al. [24]	2021	China	5	4/1 (80)	33, 56, 34, 45, 54	0	3/2
Total			24	15/4 (78.9)	42±13	7 (36.8)	9/16

Values are expressed as number (%) or mean±standard deviation.

IgG4, immunoglobulin G4; NA, not available.

^a One patient received both glucocorticoid treatment and thyroidectomy;

^b Of six cases of Riedel’s thyroiditis (RT), five had IgG4-related RT;

^c Of six cases of RT, three had tissue IgG4 immunostaining.

Table 4.

Summary of Previously Reported Cases of IgG4-Related Graves’ Disease.

Study	Year	Country	Study design	Prevalence of elevated IgG4 in GD	Sex, F/M (F proportion)	Age, yr	Prevalence of TED in the GD group with elevated IgG4
Takeshima et al. [43]	2014	Japan	Prospective	7/109 (6.4)	6/1	55±6	3/7 (42.9)
Bozkirli et al. [44]	2015	Turkey	Cross-sectional	15/65 (23.1)	NA	NA	12/15 (80)
Sy et al. [45]^a	2016	USA	Case series	2/24 (8.3)^b	2/0 (100)	44±16	24/24 (100)
Torimoto et al. [46]	2017	Japan	Cross-sectional	5/72 (6.9)	1/4 (20)	43±19	NA
Martin et al. [47]	2017	Romania	Prospective	8/80 (10)	5/3 (62.5)	39±15	3/8 (37.5)
Yu et al. [48]	2017	Korea	Case-control	6/64 (9.4)	4/2 (66.7)	32±10	6/6 (100)
Hiratsuka et al. [49]^a	2018	Japan	Longitudinal	2/28 (7.1)^b	2/0 (100)	66, 70	1/2 (50)
Luo et al. [50]	2020	China	Case-control	8/57 (14.0)^a	6/1 (85.7)	51±13	57/57 (100)

Values are expressed as number (%) or mean±standard deviation.

IgG4, immunoglobulin G4; GD, Graves’ disease; TED, thyroid eye disease; NA, not available.

^a These two studies were conducted in patients with TED;

^b Prevalence of elevated IgG4 in GD patients with TED.

REFERENCES

1. Stone JH, Khosroshahi A, Deshpande V, Chan JK, Heathcote JG, Aalberse R, et al. Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations. Arthritis Rheum 2012;64:3061-7.
[CROSSREF] [PUBMED] [PMC]

2. Kottahachchi D, Topliss DJ. Immunoglobulin G4-related thyroid diseases. Eur Thyroid J 2016;5:231-9.
[CROSSREF] [PUBMED] [PMC]

3. Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 2001;344:732-8.
[CROSSREF] [PUBMED]

4. Yamamoto M, Takahashi H, Ohara M, Suzuki C, Naishiro Y, Yamamoto H, et al. A new conceptualization for Mikulicz’s disease as an IgG4-related plasmacytic disease. Mod Rheumatol 2006;16:335-40.
[CROSSREF] [PUBMED] [PMC]

5. Fujimori N, Ito T, Igarashi H, Oono T, Nakamura T, Niina Y, et al. Retroperitoneal fibrosis associated with immunoglobulin G4-related disease. World J Gastroenterol 2013;19:35-41.
[CROSSREF] [PUBMED] [PMC]

6. Geyer JT, Ferry JA, Harris NL, Stone JH, Zukerberg LR, Lauwers GY, et al. Chronic sclerosing sialadenitis (Kuttner tumor) is an IgG4-associated disease. Am J Surg Pathol 2010;34:202-10.
[PUBMED]

7. Dahlgren M, Khosroshahi A, Nielsen GP, Deshpande V, Stone JH. Riedel’s thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum. Arthritis Care Res (Hoboken) 2010;62:1312-8.
[CROSSREF] [PUBMED]

8. Rotondi M, Carbone A, Coperchini F, Fonte R, Chiovato L. Diagnosis of endocrine disease: IgG4-related thyroid autoimmune disease. Eur J Endocrinol 2019;180:R175-83.
[CROSSREF] [PUBMED]

9. Komatsu K, Hamano H, Ochi Y, Takayama M, Muraki T, Yoshizawa K, et al. High prevalence of hypothyroidism in patients with autoimmune pancreatitis. Dig Dis Sci 2005;50:1052-7.
[CROSSREF] [PUBMED]

10. Sah RP, Chari ST. Clinical hypothyroidism in autoimmune pancreatitis. Pancreas 2010;39:1114-6.
[CROSSREF] [PUBMED]

11. Li Y, Bai Y, Liu Z, Ozaki T, Taniguchi E, Mori I, et al. Immunohistochemistry of IgG4 can help subclassify Hashimoto’s autoimmune thyroiditis. Pathol Int 2009;59:636-41.
[CROSSREF] [PUBMED]

12. Topliss DJ. Clinical update in aspects of the management of autoimmune thyroid diseases. Endocrinol Metab (Seoul) 2016;31:493-9.
[CROSSREF] [PUBMED] [PMC]

13. Li Y, Zhou G, Ozaki T, Nishihara E, Matsuzuka F, Bai Y, et al. Distinct histopathological features of Hashimoto’s thyroiditis with respect to IgG4-related disease. Mod Pathol 2012;25:1086-97.
[CROSSREF] [PUBMED]

14. Zhao Z, Lee YJ, Zheng S, Khor LY, Lim KH. IgG4-related disease of the thyroid gland requiring emergent total thyroidectomy: a case report. Head Neck Pathol 2019;13:523-7.
[CROSSREF] [PUBMED]

15. Jokisch F, Kleinlein I, Haller B, Seehaus T, Fuerst H, Kremer M. A small subgroup of Hashimoto’s thyroiditis is associated with IgG4-related disease. Virchows Arch 2016;468:321-7.
[CROSSREF] [PUBMED]

16. Zhang J, Zhao L, Gao Y, Liu M, Li T, Huang Y, et al. A classification of Hashimoto’s thyroiditis based on immunohistochemistry for IgG4 and IgG. Thyroid 2014;24:364-70.
[CROSSREF] [PUBMED]

17. Lee IS, Lee JU, Lee KJ, Jang YS, Lee JM, Kim HS. Painful immunoglobulin G4-related thyroiditis treated by total thyroidectomy. Korean J Intern Med 2016;31:399-402.
[CROSSREF] [PUBMED] [PMC]

18. Kim CS, Lee SJ, Park JS, Nam JY, Kim DM, Ahn CW, et al. A case of Riedel’s thyroiditis in a patient with a history of subacute thyroiditis. J Korean Soc Endocrinol 2003;18:414-9.

19. Lee DY, Moon JS, Kim GE, Kim HK, Kang HC. Riedel thyroiditis in a patient with graves disease. Endocrinol Metab (Seoul) 2013;28:138-43.
[CROSSREF] [PUBMED] [PMC]

20. Song E, Oh HS, Jeon MJ, Chung KW, Hong SJ, Ryu JS, et al. The value of preoperative antithyroidperoxidase antibody as a novel predictor of recurrence in papillary thyroid carcinoma. Int J Cancer 2019;144:1414-20.
[CROSSREF] [PUBMED]

21. Choi EK, Kim MH, Lee TY, Kwon S, Oh HC, Hwang CY, et al. The sensitivity and specificity of serum immunoglobulin G and immunoglobulin G4 levels in the diagnosis of autoimmune chronic pancreatitis: Korean experience. Pancreas 2007;35:156-61.
[PUBMED]

22. Takeshima K, Li Y, Kakudo K, Hirokawa M, Nishihara E, Shimatsu A, et al. Proposal of diagnostic criteria for IgG4-related thyroid disease. Endocr J 2021;68:1-6.
[CROSSREF] [PUBMED]

23. Li Y, Inomata K, Nishihara E, Kakudo K. IgG4 thyroiditis in the Asian population. Gland Surg 2020;9:1838-46.
[CROSSREF] [PUBMED] [PMC]

24. Yu Y, Liu J, Yu N, Zhang Y, Zhang S, Li T, et al. IgG4 immunohistochemistry in Riedel’s thyroiditis and the recommended criteria for diagnosis: a case series and literature review. Clin Endocrinol (Oxf) 2021;94:851-7.
[CROSSREF] [PUBMED]

25. Olejarz M, Szczepanek-Parulska E, Dadej D, Sawicka-Gutaj N, Domin R, Ruchala M. IgG4 as a biomarker in Graves’ orbitopathy. Mediators Inflamm 2021;2021:5590471.
[CROSSREF] [PUBMED] [PMC]

26. Li Y, Nishihara E, Hirokawa M, Taniguchi E, Miyauchi A, Kakudo K. Distinct clinical, serological, and sonographic characteristics of Hashimoto’s thyroiditis based with and without IgG4-positive plasma cells. J Clin Endocrinol Metab 2010;95:1309-17.
[CROSSREF] [PUBMED]

27. Kawashima ST, Tagami T, Nakao K, Nanba K, Tamanaha T, Usui T, et al. Serum levels of IgG and IgG4 in Hashimoto thyroiditis. Endocrine 2014;45:236-43.
[CROSSREF] [PUBMED]

28. Takeshima K, Ariyasu H, Inaba H, Inagaki Y, Yamaoka H, Furukawa Y, et al. Distribution of serum immunoglobulin G4 levels in Hashimoto’s thyroiditis and clinical features of Hashimoto’s thyroiditis with elevated serum immunoglobulin G4 levels. Endocr J 2015;62:711-7.
[CROSSREF] [PUBMED]

29. Raess PW, Habashi A, El Rassi E, Milas M, Sauer DA, Troxell ML. Overlapping morphologic and immunohistochemical features of Hashimoto thyroiditis and IgG4-related thyroid disease. Endocr Pathol 2015;26:170-7.
[CROSSREF] [PUBMED]

30. Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, et al. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol 2012;22:21-30.
[CROSSREF] [PUBMED]

31. Katz SM, Vickery AL Jr. The fibrous variant of Hashimoto’s thyroiditis. Hum Pathol 1974;5:161-70.
[CROSSREF] [PUBMED]

32. Deshpande V, Huck A, Ooi E, Stone JH, Faquin WC, Nielsen GP. Fibrosing variant of Hashimoto thyroiditis is an IgG4 related disease. J Clin Pathol 2012;65:725-8.
[CROSSREF] [PUBMED]

33. Hay ID. Thyroiditis: a clinical update. Mayo Clin Proc 1985;60:836-43.
[CROSSREF] [PUBMED]

34. Pusztaszeri M, Triponez F, Pache JC, Bongiovanni M. Riedel’s thyroiditis with increased IgG4 plasma cells: evidence for an underlying IgG4-related sclerosing disease? Thyroid 2012;22:964-8.
[CROSSREF] [PUBMED]

35. Cameselle-Teijeiro J, Ladra MJ, Abdulkader I, Eloy C, Soares P, Barreiro F, et al. Increased lymphangiogenesis in Riedel thyroiditis (immunoglobulin G4-related thyroid disease). Virchows Arch 2014;465:359-64.
[CROSSREF] [PUBMED]

36. Takeshima K, Inaba H, Ariyasu H, Furukawa Y, Doi A, Nishi M, et al. Clinicopathological features of Riedel’s thyroiditis associated with IgG4-related disease in Japan. Endocr J 2015;62:725-31.
[CROSSREF] [PUBMED]

37. Stan MN, Sonawane V, Sebo TJ, Thapa P, Bahn RS. Riedel’s thyroiditis association with IgG4-related disease. Clin Endocrinol (Oxf) 2017;86:425-30.
[CROSSREF] [PUBMED]

38. Simoes CA, Tavares MR, Andrade NM, Uehara TM, Dedivitis RA, Cernea CR. Does the intensity of IGG4 immunostaining have a correlation with the clinical presentation of Riedel’s thyroiditis? Case Rep Endocrinol 2018;2018:4101323.
[PUBMED] [PMC]

39. Falhammar H, Juhlin CC, Barner C, Catrina SB, Karefylakis C, Calissendorff J. Riedel’s thyroiditis: clinical presentation, treatment and outcomes. Endocrine 2018;60:185-92.
[CROSSREF] [PUBMED] [PMC]

40. Blanco VM, Paez CA, Victoria AM, Arango LG, Arrunategui AM, Escobar J, et al. Riedel’s thyroiditis: report of two cases and literature review. Case Rep Endocrinol 2019;2019:5130106.
[CROSSREF] [PUBMED] [PMC]

41. Hennessey JV. Clinical review: Riedel’s thyroiditis: a clinical review. J Clin Endocrinol Metab 2011;96:3031-41.
[PUBMED]

42. Nishihara E, Hirokawa M, Takamura Y, Ito M, Nakamura H, Amino N, et al. Immunoglobulin G4 thyroiditis in a Graves’ disease patient with a large goiter developing hypothyroidism. Thyroid 2013;23:1496-7.
[CROSSREF] [PUBMED]

43. Takeshima K, Inaba H, Furukawa Y, Nishi M, Yamaoka H, Miyamoto W, et al. Elevated serum immunoglobulin G4 levels in patients with Graves’ disease and their clinical implications. Thyroid 2014;24:736-43.
[CROSSREF] [PUBMED]

44. Bozkirli E, Bakiner OS, Ersozlu Bozkirli ED, Eksi Haydardedeoglu F, Sizmaz S, Torun AI, et al. Serum immunoglobulin G4 levels are elevated in patients with Graves’ ophthalmopathy. Clin Endocrinol (Oxf) 2015;83:962-7.
[CROSSREF] [PUBMED]

45. Sy A, Silkiss RZ. Serum total IgG and IgG4 levels in thyroid eye disease. Int Med Case Rep J 2016;9:325-8.
[CROSSREF] [PUBMED] [PMC]

46. Torimoto K, Okada Y, Kurozumi A, Narisawa M, Arao T, Tanaka Y. Clinical features of patients with Basedow’s disease and high serum IgG4 levels. Intern Med 2017;56:1009-13.
[CROSSREF] [PUBMED] [PMC]

47. Martin CS, Sirbu AE, Betivoiu MA, Florea S, Barbu CG, Fica SV. Serum immunoglobulin G4 levels and Graves’ disease phenotype. Endocrine 2017;55:478-84.
[CROSSREF] [PUBMED]

48. Yu SH, Kang JG, Kim CS, Ihm SH, Choi MG, Yoo HJ, et al. Clinical implications of immunoglobulin G4 to Graves’ ophthalmopathy. Thyroid 2017;27:1185-93.
[CROSSREF] [PUBMED]

49. Hiratsuka I, Yamada H, Itoh M, Shibata M, Takayanagi T, Makino M, et al. Changes in serum immunoglobulin G4 levels in patients with newly diagnosed Graves’ disease. Exp Clin Endocrinol Diabetes 2020;128:119-24.
[CROSSREF] [PUBMED]

50. Luo B, Yuan X, Wang W, Zhang J, Liu R, Hu W, et al. Ocular manifestations and clinical implications of serum immunoglobulin G4 levels in Graves’ ophthalmopathy patients. Ocul Immunol Inflamm 2020 Oct 15 [Epub]. https://doi.org/10.1080/09273948.2020.1826537.
[CROSSREF]