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| Purification of human RBC insulin receptor by high performance insulin affinity column. |
| Myung Hi Yoo, Guk Bae Kim, Hi Bahl Lee |
| Endocrinol Metab. 1991;6(4):308-313. Published online January 1, 2001 |
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Evidence that insulin receptor from human placenta has a high affinity for only one molecule of insulin. Journal of Biological Chemistry. 1984;259(13):8589-8596  High affinity insulin binding in the human placenta insulin receptor requires αβ heterodimeric subunit interactions The Journal of Membrane Biology. 1989;108(3):217-225 Basal autophosphorylation of insulin receptor occurs preferentially on the receptor conformation exhibiting high affinity for insulin and stabilizes this conformation Cellular Signalling. 1990;2(6):587-594 Mutation of the High Cysteine Region of the Human Insulin Receptor α-Subunit Increases Insulin Receptor Binding Affinity and Transmembrane Signaling Journal of Biological Chemistry. 1989;264(27):15900-15904 High affinity antibody from hen's eggs directed against the human insulin receptor and the human IGF-I receptor Analytical Biochemistry. 1988;173(1):142-150 High affinity insulin binding and insulin receptor-effector coupling: Modulation by Ca2+ Cell Calcium. 1990;11(8):547-556 Replacements of Leucine 87 in Human Insulin Receptor Alter Affinity for Insulin Journal of Biological Chemistry. 1995;270(37):22017-22022 Insulin resistance induced by high glucose and high insulin precedes insulin receptor substrate 1 protein depletion in human adipocytes Metabolism. 2007;56(2):190-198 Insulin down-regulates insulin receptor number and up-regulates insulin receptor affinity in cells expressing a tyrosine kinase-defective insulin receptor. Journal of Biological Chemistry. 1990;265(9):4902-4907 Familial insulin-resistant diabetes secondary to an affinity defect of the insulin receptor Human Genetics. 1983;64(4):407-411 |
