Endocrinology and Metabolism

Review Article

August 20, 2020

Metabolically Healthy and Unhealthy Normal Weight and Obesity

Norbert Stefan

Endocrinol Metab. 2020;35(3):487-493.

Increased fat mass is an established risk factor for the cardiometabolic diseases type 2 diabetes and cardiovascular disease (CVD) and is associated with increased risk of all-cause and CVD mortality....

Review Article

September 8, 2020

WD40-Repeat Proteins in Ciliopathies and Congenital Disorders of Endocrine System

Yeonjoo Kim, Soo-Hyun Kim

Endocrinol Metab. 2020;35(3):494-506.

WD40-repeat (WDR)-containing proteins constitute an evolutionarily conserved large protein family with a broad range of biological functions. In human proteome, WDR makes up one of the most abundant protein-protein interaction...

Review Article

September 22, 2020

Systems Biology: A Multi-Omics Integration Approach to Metabolism and the Microbiome

Jang Won Son, Saeed Shoaie, Sunjae Lee

Endocrinol Metab. 2020;35(3):507-514.

The complex and dynamic nature of human physiology, as exemplified by metabolism, has often been overlooked due to the lack of quantitative and systems approaches. Recently, systems biology approaches have...

Review Article

September 22, 2020

Mechanisms of TERT Reactivation and Its Interaction with BRAF^V600E

Young Shin Song, Young Joo Park

Endocrinol Metab. 2020;35(3):515-525.

The telomerase reverse transcriptase (TERT) gene, which is repressed in most differentiated human cells, can be reactivated by somatic TERT alterations and epigenetic modulations. Moreover, the recruitment, accessibility, and binding...

Review Article

September 22, 2020

Current National and International Guidelines for the Management of Male Hypogonadism: Helping Clinicians to Navigate Variation in Diagnostic Criteria and Treatment Recommendations

Ahmed Al-Sharefi, Richard Quinton

Endocrinol Metab. 2020;35(3):526-540.

Male hypogonadism—rebadged by some as testosterone deficiency syndrome—is a clinical and biochemical diagnosis of increasing worldwide interest. Organic male hypogonadism—usually permanent—is well-established, but aging men may also exhibit lower serum...

Review Article

September 22, 2020

Lessons from Use of Continuous Glucose Monitoring Systems in Digital Healthcare

Hun-Sung Kim, Kun-Ho Yoon

Endocrinol Metab. 2020;35(3):541-548.

We live in a digital world where a variety of wearable medical devices are available. These technologies enable us to measure our health in our daily lives. It is increasingly...

Original Article

Clinical Study

July 22, 2020

The Prevalence and Risk of Type 2 Diabetes in Adults with Disabilities in Korea

Inha Jung, Hyemi Kwon, Se Eun Park, et al.

Endocrinol Metab. 2020;35(3):552-561.

Background: People with disabilities are at risk of secondary conditions such as diabetes. The aim of this study was to evaluate the prevalence and risk of type 2 diabetes in...

Original Article

Clinical Study

September 22, 2020

Effects of Systemic Glucocorticoid Use on Fracture Risk: A Population-Based Study

Ji Weon Koh, Junkang Kim, Hyemin Cho, et al.

Endocrinol Metab. 2020;35(3):562-570.

Background: Long-term glucocorticoid use increases fracture risk by reducing bone mass. This study evaluated the relationship between hip and vertebral fractures and the total amount of systematic glucocorticoid use. Methods: We...

Original Article

Clinical Study

September 22, 2020

A Phase II Multi-Center, Non-Randomized, Parallel Group, Non-Inferiority Study to Compare the Efficacy of No Radioactive Iodine Remnant Ablation to Remnant Ablation Treatment in Low- to Intermediate-Risk of Papillary Thyroid Cancer: The MOREthyroid Trial Protocol

Eun Kyung Lee, You Jin Lee, Young Joo Park, et al.

Endocrinol Metab. 2020;35(3):571-577.

Background: Radioactive iodine (RAI) remnant ablation is recommended in patients with papillary thyroid cancer (PTC) and extrathyroidal extension or central lymph node metastasis. However, there exists little evidence about the...

Original Article

Clinical Study

September 22, 2020

Relationship of Sarcopenia with Microcirculation Measured by Skin Perfusion Pressure in Patients with Type 2 Diabetes

Chan-Hee Jung, Yoon Young Cho, Dughyun Choi, et al.

Endocrinol Metab. 2020;35(3):578-586.

Background: Few studies have examined the relationship of sarcopenia with the microcirculation. The current study investigated the relationship of sarcopenia with microcirculatory function, as assessed by skin perfusion pressure (SPP),...

Original Article

Clinical Study

September 22, 2020

Vandetanib for the Management of Advanced Medullary Thyroid Cancer: A Real-World Multicenter Experience

Mijin Kim, Jee Hee Yoon, Jonghwa Ahn, et al.

Endocrinol Metab. 2020;35(3):587-594.

Background: Vandetanib is the most widely used tyrosine kinase inhibitor for the treatment of patients with advanced medullary thyroid cancer (MTC). However, only limited data regarding its use outside clinical...

Original Article

Clinical Study

August 26, 2020

Fasting Plasma Glucose Level Independently Predicts the Mortality of Patients with Coronavirus Disease 2019 Infection: A Multicenter, Retrospective Cohort Study

Min Cheol Chang, Jong-Moon Hwang, Jae-Han Jeon, et al.

Endocrinol Metab. 2020;35(3):595-601.

Background: Coronavirus disease 2019 (COVID-19) has become a global pandemic, which prompts a consensus for the necessity to seek risk factors for this critical disease. Risk factors affecting mortality of...

Original Article

Clinical Study

September 22, 2020

Clinical Outcomes of N1b Papillary Thyroid Cancer Patients Treated with Two Different Doses of Radioiodine Ablation Therapy

Meihua Jin, Jonghwa Ahn, Yu-Mi Lee, et al.

Endocrinol Metab. 2020;35(3):602-609.

Background: The optimal dose of radioactive iodine (RAI) therapy for N1b papillary thyroid carcinoma (PTC) is controversial. We evaluated the clinical outcome of N1b PTC patients treated with either 100...

Original Article

Clinical Study

September 22, 2020

Serum Transferrin Predicts New-Onset Type 2 Diabetes in Koreans: A 4-Year Retrospective Longitudinal Study

Jong Dai Kim, Dong-Mee Lim, Keun-Young Park, et al.

Endocrinol Metab. 2020;35(3):610-617.

Background: It is well known that high serum ferritin, a marker of iron storage, predicts incident type 2 diabetes. Limited information is available on the association between transferrin, another marker...

Original Article

Clinical Study

September 22, 2020

Clinical Implication of World Health Organization Classification in Patients with Follicular Thyroid Carcinoma in South Korea: A Multicenter Cohort Study

Meihua Jin, Eun Sook Kim, Bo Hyun Kim, et al.

Endocrinol Metab. 2020;35(3):618-627.

Background: The study aimed to compare the prognostic value of the 4th edition of World Health Organization classification (WHO-2017) with the previous WHO classification (WHO-2004) for follicular thyroid carcinoma (FTC). Methods:...

Original Article

Clinical Study

September 22, 2020

Stimulated Salivary Cortisol as a Noninvasive Diagnostic Tool for Adrenal Insufficiency

Yoon Ji Kim, Jung Hee Kim, A Ram Hong, et al.

Endocrinol Metab. 2020;35(3):628-635.

Background: Salivary cortisol is routinely used as a diagnostic test for Cushing syndrome. The diagnostic use of salivary cortisol for adrenal insufficiency (AI), however, is less established. We aimed to...

Original Article

Clinical Study

September 22, 2020

Predicting the Development of Myocardial Infarction in Middle-Aged Adults with Type 2 Diabetes: A Risk Model Generated from a Nationwide Population-Based Cohort Study in Korea

Seung-Hwan Lee, Kyungdo Han, Hun-Sung Kim, et al.

Endocrinol Metab. 2020;35(3):636-646.

Background: Most of the widely used prediction models for cardiovascular disease are known to overestimate the risk of this disease in Asians. We aimed to generate a risk model for...

Original Article

Endocrine Research

September 22, 2020

Irisin Regulates the Functions of Hepatic Stellate Cells

Hanh Nguyen Dong, So Young Park, Cong Thuc Le, et al.

Endocrinol Metab. 2020;35(3):647-655.

Background: Hepatic stellate cells (HSCs) are known to play a fundamental role in the progression of liver fibrosis. Once HSCs are activated, they are involved in proliferation, migration, and contractility...

Original Article

Endocrine Research

August 20, 2020

Liver X Receptor β Related to Tumor Progression and Ribosome Gene Expression in Papillary Thyroid Cancer

Seonhyang Jeong, In-Kyu Kim, Hyunji Kim, et al.

Endocrinol Metab. 2020;35(3):656-668.

Background: Intracellular lipid deposition has been reported in thyroid glands in obese animal and human. To understand the regulatory mechanism of lipid metabolism in thyroid cancer, we investigated the expression...

Current Issue: Volume 35(3); Sep 2020

Reference Ranges of Serum Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3: Results from a Multicenter Study in Healthy Korean Adults In-Kyung Jeong, Jong Kyu Byun, Junghyun Noh, et al. [Epub ahead of print] Brief Report Dec 1, 2020 PDF	The Association of Overt and Subclinical Hyperthyroidism with the Risk of Cardiovascular Events and Cardiovascular Mortality: Meta-Analysis and Systematic Review of Cohort Studies Seo Young Sohn, Eunyoung Lee, Min Kyung Lee, et al. [Epub ahead of print] Original Article Nov 25, 2020 PDF
Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults Sung Hye Kong, Ji Won Yoon, Jung Hee Kim, et al. [Epub ahead of print] Original Article Nov 24, 2020 PDF	Transcriptome Analysis Identifies an Attenuated Local Immune Response in Invasive Nonfunctioning Pituitary Adenomas Yong Hwy Kim, Jung Hee Kim [Epub ahead of print] Corrigendum Nov 23, 2020 PDF
Establishment of Reference Intervals for Serum Insulin-Like Growth Factor I in Korean Adult Population Boyeon Kim, Yonggeun Cho, Cheol Ryong Ku, et al. [Epub ahead of print] Brief Report Nov 20, 2020 PDF	Trends in the Diagnosis and Treatment of Patients with Medullary Thyroid Carcinoma in Korea Hwa Young Ahn, Jae Eun Chae, Hyemi Moon, et al. [Epub ahead of print] Original Article Nov 20, 2020 PDF
Cross-Sectional and Longitudinal Examination of Insulin Sensitivity and Secretion across Puberty among NonHispanic Black and White Children Shannon E. Marwitz, Megan V. Gaines, Sheila M. Brady, et al. [Epub ahead of print] Original Article Nov 18, 2020 PDF	Clinical Outcomes after Early and Delayed Radioiodine Remnant Ablation in Patients with Low-Risk Papillary Thyroid Carcinoma: Propensity Score Matching Analysis Jonghwa Ahn, Meihua Jin, Eyun Song, et al. [Epub ahead of print] Original Article Nov 18, 2020 PDF
Insulin Secretion and Insulin Resistance Trajectories over 1 Year after Kidney Transplantation: A Multicenter Prospective Cohort Study Jun Bae Bang, Chang-Kwon Oh, Yu Seun Kim, et al. [Epub ahead of print] Original Article Nov 18, 2020 PDF	Tumor Cells and Cancer-Associated Fibroblasts: A Synergistic Crosstalk to Promote Thyroid Cancer Laura Fozzatti, Sheue-yann Cheng [Epub ahead of print] Review Article Nov 9, 2020 PDF

Endocrinology
and Metabolism

Print ISSN: 2093-596X
Online ISSN: 2093-5978

4,863	Protein Expression of Cyclin B1, Transferrin Receptor, and Fibronectin Is Correlated with the Prognosis of Adrenal Cortical Carcinoma
3,424	Effects of Cardiovascular Risk Factor Variability on Health Outcomes
3,448	Encountering COVID-19 as Endocrinologists
2,510	Association of Body Mass Index with the Risk of Incident Type 2 Diabetes, Cardiovascular Disease, and All-Cause Mortality: A Community-Based Prospective Study
2,375	Relationships between Thigh and Waist Circumference, Hemoglobin Glycation Index, and Carotid Plaque in Patients with Type 2 Diabetes

Cited By 42	Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease
Cited By 25	Genome-Wide Association Studies of Autoimmune Thyroid Diseases, Thyroid Function, and Thyroid Cancer
Cited By 24	Effects of Resistance Exercise on Bone Health
Cited By 22	Evidence of the Possible Harm of Endocrine-Disrupting Chemicals in Humans: Ongoing Debates and Key Issues
Cited By 19	Recent Updates on the Diagnosis and Management of Cushing's Syndrome