Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Article type

Page Path
HOME > BROWSE ARTICLES > Article type
2470 Article type
Filter
Filter
Article type
Keywords
Publication year
Authors
Funded articles
Review Articles
Obesity and Metabolism
Trends in the Diabetes Epidemic in Korea
Kyoung Hwa Ha, Dae Jung Kim
Endocrinol Metab. 2015;30(2):142-146.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.142
  • 4,790 View
  • 45 Download
  • 65 Web of Science
  • 77 Crossref
AbstractAbstract PDFPubReader   

Diabetes mellitus is a leading cause of mortality and increased disability-adjusted life years worldwide. In Korea, the prevalence of diabetes increased from 8.6% to 11.0% in 2001 to 2013 and the prevalence of adult obesity, which is the most important risk factor of diabetes, increased from 29.2% to 31.8% during the same period. There has been a dramatic increase in the number of obese Koreans with diabetes in recent decades and the prevalence of diabetes in people aged 40 years and older also increased in 2001 to 2013. Nevertheless, the mean age at the first diagnosis of diabetes was very similar for men in 2005 and 2013, while the mean age for women decreased slightly. There is an inverse linear relationship between body mass index and age at the diagnosis of diabetes among those who are newly diagnosed. Accordingly, the prevalence of diabetes is increasingly shifting to younger individuals and those who are obese. Therefore, public efforts should focus on healthy lifestyle changes, primary prevention measures, screening for the early detection of diabetes, and long-term management.

Citations

Citations to this article as recorded by  
  • Smoking behavior change and the risk of pneumonia hospitalization among smokers with diabetes mellitus
    Dong-Woo Han, Wonyoung Jung, Kyu Na Lee, Kyungdo Han, Sei Won Lee, Dong Wook Shin
    Scientific Reports.2023;[Epub]     CrossRef
  • Effects of Teneligliptin on HbA1c levels, Continuous Glucose Monitoring-Derived Time in Range and Glycemic Variability in Elderly Patients with T2DM (TEDDY Study)
    Ji Cheol Bae, Soo Heon Kwak, Hyun Jin Kim, Sang-Yong Kim, You-Cheol Hwang, Sunghwan Suh, Bok Jin Hyun, Ji Eun Cha, Jong Chul Won, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2022; 46(1): 81.     CrossRef
  • Rising Incidence of Diabetes in Young Adults in South Korea: A National Cohort Study
    Hyun Ho Choi, Giwoong Choi, Hojun Yoon, Kyoung Hwa Ha, Dae Jung Kim
    Diabetes & Metabolism Journal.2022; 46(5): 803.     CrossRef
  • Differences in health behavior and nutrient intake status between diabetes-aware and unaware Korean adults based on the Korea national health and nutrition examination survey 2016–18 data: A cross-sectional study
    Anshul Sharma, Chen Lulu, Kee-Ho Song, Hae-Jeung Lee
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Triglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort
    Byoungjin Park, Hye Sun Lee, Yong-Jae Lee
    Translational Research.2021; 228: 42.     CrossRef
  • Did Sejong the Great have ankylosing spondylitis? The oldest documented case of ankylosing spondylitis
    JiHwan Lee
    International Journal of Rheumatic Diseases.2021; 24(2): 203.     CrossRef
  • Diabetes Fact Sheets in Korea, 2020: An Appraisal of Current Status
    Chan-Hee Jung, Jang Won Son, Shinae Kang, Won Jun Kim, Hun-Sung Kim, Hae Soon Kim, Mihae Seo, Hye-Jung Shin, Seong-Su Lee, Su Jin Jeong, Yongin Cho, Seung Jin Han, Hyang Mi Jang, Mira Rho, Shinbi Lee, Mihyun Koo, Been Yoo, Jung-Wha Moon, Hye Young Lee, Ja
    Diabetes & Metabolism Journal.2021; 45(1): 1.     CrossRef
  • Association between living alone and incident type 2 diabetes among middle-aged individuals in Korea: a nationwide cohort study
    Ga Eun Nam, Wonsock Kim, Kyungdo Han, Jin-Hyung Jung, Byoungduck Han, Jinwook Kim, Nan Hee Kim, Kyung Mook Choi, Kyung Hwan Cho, Yong Gyu Park, Seon Mee Kim
    Scientific Reports.2021;[Epub]     CrossRef
  • White Blood Cell Count as a Predictor of Incident Type 2 Diabetes Mellitus Among Non-Obese Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study
    Jae-Min Park, Hye Sun Lee, Ju-Young Park, Dong-Hyuk Jung, Ji-Won Lee
    Journal of Inflammation Research.2021; Volume 14: 1235.     CrossRef
  • A 9-Year Comparison of Dementia Prevalence in Korea: Results of NaSDEK 2008 and 2017
    Seung Wan Suh, You Joung Kim, Kyung Phil Kwak, Kiwon Kim, Moon-Doo Kim, Byung-Soo Kim, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hui Kim, Seok Woo Moon, Kyung Won Park, Jong-Il Park, Joon Hyuk Park, Jae Nam Bae, Jiyeong Seo, Su Jeong Seong, Sang Joo
    Journal of Alzheimer's Disease.2021; 81(2): 821.     CrossRef
  • Trends of Diabetes and Prediabetes Prevalence among Korean Adolescents From 2007 to 2018
    Ji Hyun Kim, Jung Sub Lim
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Breast Cancer Statistics in Korea, 2018
    Sang Yull Kang, Sae Byul Lee, Yoo Seok Kim, Zisun Kim, Hyun Yul Kim, Hee Jeong Kim, Sungmin Park, Soo Youn Bae, Kwanghyun Yoon, Se Kyung Lee, Kyu-Won Jung, Jaihong Han, Hyun Jo Youn
    Journal of Breast Cancer.2021; 24(2): 123.     CrossRef
  • Longitudinal Changes in Clinical Features, Management, and Outcomes of Idiopathic Pulmonary Fibrosis. A Nationwide Cohort Study
    Sung Woo Moon, Song Yee Kim, Man Pyo Chung, Hongseok Yoo, Sung Hwan Jeong, Dong Soon Kim, Jin Woo Song, Hong Lyeol Lee, Sun Mi Choi, Young Whan Kim, Yong Hyun Kim, Choon-Sik Park, Sung-Woo Park, Jong Sun Park, Yangjin Jegal, Jongmin Lee, Soo-Taek Uh, Tae-
    Annals of the American Thoracic Society.2021; 18(5): 780.     CrossRef
  • Association between Inflammatory Markers and Glycemic Control in Korean Diabetic Patients
    Min Kang, Seok-Joon Sohn
    Journal of Health Informatics and Statistics.2021; 46(3): 247.     CrossRef
  • Associations between obesity, weight change and decreased renal function in Korean type 2 diabetic patients: a longitudinal follow-up study
    Bo-Yeon Kim, Dug-Hyun Choi, Chan-Hee Jung, Ji-Oh Mok, Chul-Hee Kim
    BMC Endocrine Disorders.2021;[Epub]     CrossRef
  • Role of Estrogen in Type 1 and Type 2 Diabetes Mellitus: A Review of Clinical and Preclinical Data
    Monica De Paoli, Geoff H. Werstuck
    Canadian Journal of Diabetes.2020; 44(5): 448.     CrossRef
  • Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea
    Suk Kyeong Kim, Ju-Young Jang, Dong-Lim Kim, Young A Rhyu, Suh Eun Lee, Seung-Hyun Ko, Kyungdo Han, Kee-Ho Song
    The Korean Journal of Internal Medicine.2020; 35(3): 641.     CrossRef
  • Alteration of Microbiome Profile by D-Allulose in Amelioration of High-Fat-Diet-Induced Obesity in Mice
    Youngji Han, Haryung Park, Bo-Ra Choi, Yosep Ji, Eun-Young Kwon, Myung-Sook Choi
    Nutrients.2020; 12(2): 352.     CrossRef
  • Type 2 diabetes: epidemiological changes at Instituto Mexicano del Seguro Social—associated with complications in Mexico
    Jessie N. Zurita-Cruz, Leticia Manuel-Apolinar, María Luisa Arellano-Flores, Alejandro Gutierrez-Gonzalez, Aleida de Jesús Rivera-Hernández, Rosa Angélica Carranza-Muleiro, Víctor Hugo Borja-Aburto, Nelly Cisneros-González
    International Journal of Diabetes in Developing Countries.2020; 40(2): 178.     CrossRef
  • Effects of Particulate Respirator Use on Cardiopulmonary Function in Elderly Women: a Quasi-Experimental Study
    Youn-Hee Lim, Woosung Kim, Yumi Choi, Hwan-Cheol Kim, Geunjoo Na, Hyoung-Ryoul Kim, Yun-Chul Hong
    Journal of Korean Medical Science.2020;[Epub]     CrossRef
  • GLP‑1 receptor agonist on cardiovascular complications of diabetes mellitus
    Fengjun Liu, Yanhua Kong
    Experimental and Therapeutic Medicine.2020;[Epub]     CrossRef
  • Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity
    Seung-Soon Im, Hyeon Young Park, Jong Cheol Shon, In-Sung Chung, Ho Chan Cho, Kwang-Hyeon Liu, Dae-Kyu Song, Kyoung Heon Kim
    PLOS ONE.2019; 14(3): e0213285.     CrossRef
  • Diabetes Fact Sheets in Korea, 2018: An Appraisal of Current Status
    Bo-Yeon Kim, Jong Chul Won, Jae Hyuk Lee, Hun-Sung Kim, Jung Hwan Park, Kyoung Hwa Ha, Kyu Chang Won, Dae Jung Kim, Kyong Soo Park
    Diabetes & Metabolism Journal.2019; 43(4): 487.     CrossRef
  • Analysis of diabetes quality assessment findings and future directions for the appropriate management of diabetes in Korea
    Yu Jin Kim, Suk Chon, Seungjoon Oh, Jeong-taek Woo, Sung Woon Kim, Sang Youl Rhee
    The Korean Journal of Internal Medicine.2019; 34(1): 125.     CrossRef
  • Diabetes and the Risk of Infection: A National Cohort Study
    Eun Jin Kim, Kyoung Hwa Ha, Dae Jung Kim, Young Hwa Choi
    Diabetes & Metabolism Journal.2019; 43(6): 804.     CrossRef
  • Age-specific diabetes risk by the number of metabolic syndrome components: a Korean nationwide cohort study
    Min-Kyung Lee, Kyungdo Han, Hyuk-Sang Kwon
    Diabetology & Metabolic Syndrome.2019;[Epub]     CrossRef
  • Changes in real-life practice for hepatocellular carcinoma patients in the Republic of Korea over a 12-year period: A nationwide random sample study
    Beom Kyung Kim, Do Young Kim, Kwang-Hyub Han, Jinsil Seong, Jung Weon Lee
    PLOS ONE.2019; 14(10): e0223678.     CrossRef
  • Association between continuity of care and type 2 diabetes development among patients with thyroid disorder
    Sang Ah Lee, Dong-Woo Choi, Junhyun Kwon, Doo Woong Lee, Eun-Cheol Park
    Medicine.2019; 98(52): e18537.     CrossRef
  • Association of C-Reactive Protein with Risk of Developing Type 2 Diabetes Mellitus, and Role of Obesity and Hypertension: A Large Population-Based Korean Cohort Study
    Suganya Kanmani, Minji Kwon, Moon-Kyung Shin, Mi Kyung Kim
    Scientific Reports.2019;[Epub]     CrossRef
  • Egg consumption is associated with a lower risk of type 2 diabetes in middle-aged and older men
    Jieul Lee, Jihye Kim
    Nutrition Research and Practice.2018; 12(5): 396.     CrossRef
  • Diabetes, Frequency of Exercise, and Mortality Over 12 Years: Analysis of the National Health Insurance Service-Health Screening (NHIS-HEALS) Database
    Woo Young Shin, Taehee Lee, Da-Hye Jeon, Hyeon Chang Kim
    Journal of Korean Medical Science.2018;[Epub]     CrossRef
  • Epidemiology of liver cancer in South Korea
    Bo Hyun Kim, Joong-Won Park
    Clinical and Molecular Hepatology.2018; 24(1): 1.     CrossRef
  • Letter: Clinical Characteristics of People with Newly Diagnosed Type 2 Diabetes between 2015 and 2016: Difference by Age and Body Mass Index (Diabetes Metab J 2018;42:137-46)
    Ah Reum Khang
    Diabetes & Metabolism Journal.2018; 42(3): 249.     CrossRef
  • Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo-controlled clinical trial
    Han Seok Choi, Sunmi Kim, Min Jung Kim, Myung-Sunny Kim, Juewon Kim, Chan-Woong Park, Daebang Seo, Song Seok Shin, Sang Woo Oh
    Journal of Ginseng Research.2018; 42(1): 90.     CrossRef
  • Response: Clinical Characteristics of People with Newly Diagnosed Type 2 Diabetes between 2015 and 2016: Difference by Age and Body Mass Index (Diabetes Metab J2018;42:137-46)
    Kyoung Hwa Ha, Dae Jung Kim, Sungrae Kim
    Diabetes & Metabolism Journal.2018; 42(3): 251.     CrossRef
  • Prediction of Type 2 Diabetes Remission after Bariatric or Metabolic Surgery
    Ji Yeon Park
    Journal of Obesity & Metabolic Syndrome.2018; 27(4): 213.     CrossRef
  • Waist‐to‐calf circumstance ratio is an independent predictor of hepatic steatosis and fibrosis in patients with type 2 diabetes
    Eun Yeong Choe, Yong‐ho Lee, Young Ju Choi, Byung Wook Huh, Byung‐Wan Lee, Soo‐Kyung Kim, Eun Seok Kang, Bong‐Soo Cha, Eun Jig Lee, Kap Bum Huh, Zobair M Younossi
    Journal of Gastroenterology and Hepatology.2018; 33(5): 1082.     CrossRef
  • Prevalence of Comorbidities among Patients with Diabetes
    Suyoung Kim, Eun-Hee Nah, Seon Cho
    Journal of Health Informatics and Statistics.2018; 43(3): 237.     CrossRef
  • Risk of new-onset diabetes among patients treated with statins according to hypertension and gender: Results from a nationwide health-screening cohort
    Sang-Eun Lee, Ji Min Sung, In-Jeong Cho, Hyeon Chang Kim, Hyuk-Jae Chang, Lamberto Manzoli
    PLOS ONE.2018; 13(4): e0195459.     CrossRef
  • Outcomes of living donor kidney transplantation in diabetic patients: age and sex matched comparison with non-diabetic patients
    Chung Hee Baek, Hyosang Kim, Seung Don Baek, Mun Jang, Wonhak Kim, Won Seok Yang, Duck Jong Han, Su-Kil Park
    The Korean Journal of Internal Medicine.2018; 33(2): 356.     CrossRef
  • An Analysis of The Morbidity and Mortality of Diabetes Mellitus in a Forensic Context
    Chong Zhou, Roger W. Byard
    Journal of Forensic Sciences.2018; 63(4): 1149.     CrossRef
  • Favorable glycemic response after pancreatoduodenectomy in both patients with pancreatic cancer and patients with non-pancreatic cancer
    Seo Young Sohn, Eun Kyung Lee, Sung-Sik Han, You Jin Lee, Yul Hwangbo, Young Hwa Kang, Seung Duk Lee, Seong Hoon Kim, Sang Myung Woo, Woo Jin Lee, Eun Kyung Hong, Sang-Jae Park
    Medicine.2018; 97(18): e0590.     CrossRef
  • Comparison of Open and Laparoscopic Gastrectomy in Elderly Patients
    Su Mi Kim, Ho Geun Youn, Ji Yeong An, Yoon Young Choi, Sung Hoon Noh, Seung Jong Oh, Tae Sung Sohn, Sung Kim
    Journal of Gastrointestinal Surgery.2018; 22(5): 785.     CrossRef
  • Development and Validation of the Korean Diabetes Risk Score: A 10-Year National Cohort Study
    Kyoung Hwa Ha, Yong-ho Lee, Sun Ok Song, Jae-woo Lee, Dong Wook Kim, Kyung-hee Cho, Dae Jung Kim
    Diabetes & Metabolism Journal.2018; 42(5): 402.     CrossRef
  • Trends in diabetes prevalence among Korean adults based on Korean National Health and Nutrition Examination Surveys III–VI
    Jae-woo Lee, Hee-Taik Kang, Hyoung-Ji Lim, Byoungjin Park
    Diabetes Research and Clinical Practice.2018; 138: 57.     CrossRef
  • Clinical Characteristics of People with Newly Diagnosed Type 2 Diabetes between 2015 and 2016: Difference by Age and Body Mass Index
    Kyoung Hwa Ha, Cheol Young Park, In Kyung Jeong, Hyun Jin Kim, Sang-Yong Kim, Won Jun Kim, Ji Sung Yoon, In Joo Kim, Dae Jung Kim, Sungrae Kim
    Diabetes & Metabolism Journal.2018; 42(2): 137.     CrossRef
  • Nonalcoholic fatty liver disease-associated hepatocellular carcinoma in a hepatitis B virus-endemic area
    Chang Hwi Yoon, Young-Joo Jin, Jin Woo Lee
    European Journal of Gastroenterology & Hepatology.2018; 30(9): 1090.     CrossRef
  • Prediction of Diabetes Remission after Bariatric or Metabolic Surgery
    Ji Yeon Park
    Journal of Metabolic and Bariatric Surgery.2018; 7(1): 22.     CrossRef
  • Incidence and predictors of type 2 diabetes among Koreans: A 12-year follow up of the Korean Genome and Epidemiology Study
    Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Kwan Woo Lee, Nam H. Cho
    Diabetes Research and Clinical Practice.2017; 123: 173.     CrossRef
  • Glycated Hemoglobin and All-Cause Mortality in Korean Type 2 Diabetes
    Mi Suk An, Sun A Kim, Jun-Ho Lee, Seong-Woo Choi, Min-Ho Shin
    Chonnam Medical Journal.2017; 53(3): 223.     CrossRef
  • Analysis and comparison of the cost-effectiveness of statins according to the baseline low-density lipoprotein cholesterol level in Korea
    Y. J. Jeong, H. Kim, S. J. Baik, T. M. Kim, S. J. Yang, S.-H. Lee, J.-H. Cho, H. Lee, H. W. Yim, I. Y. Choi, K.-H. Yoon, H.-S. Kim
    Journal of Clinical Pharmacy and Therapeutics.2017; 42(3): 292.     CrossRef
  • Governmental or Social Support of Bariatric Surgery in the Asia-Pacific Region
    Jisun Lim, Young Hye Cho, Hiroshi Yamamoto, Alvin Eng, Tania Markovic, Kyoung Kon Kim
    Journal of Obesity & Metabolic Syndrome.2017; 26(1): 10.     CrossRef
  • Application of the 2013 American College of Cardiology/American Heart Association Cholesterol Guideline to the Korean National Health and Nutrition Examination Surveys from 1998 to 2012
    Young Shin Song, Tae Jung Oh, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang, Kyong Soo Park, Soo Lim
    Diabetes & Metabolism Journal.2017; 41(1): 38.     CrossRef
  • The differences in the incidence of diabetes mellitus and prediabetes according to the type of HMG-CoA reductase inhibitors prescribed in Korean patients
    Tong Min Kim, Hyunah Kim, Yoo Jin Jeong, Sun Jung Baik, So Jung Yang, Seung-Hwan Lee, Jae-Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun-Ho Yoon, Hun-Sung Kim
    Pharmacoepidemiology and Drug Safety.2017; 26(10): 1156.     CrossRef
  • The Effect and Safety of Dapagliflozin in Patients with Type 2 Diabetes: A Single-Institution Pharmacovigilance Review
    Hyung Woo Lee, Sun Joon Moon, Hee Sim Han, Eun Jeong Shin, Jin Hee Baek, Hyun-Joo Han, Young Min Cho, Kwi Suk Kim
    The Journal of Korean Diabetes.2017; 18(4): 275.     CrossRef
  • Optimal glycemic target level for colon cancer patients with diabetes
    Shin Jun Lee, Jae Hyun Kim, Seun Ja Park, So Young Ock, Su Kyoung Kwon, Young Sik Choi, Bu Kyung Kim
    Diabetes Research and Clinical Practice.2017; 124: 66.     CrossRef
  • Physician-Directed Diabetes Education without a Medication Change and Associated Patient Outcomes
    Hun-Sung Kim, Hyunah Kim, Hae-Kyung Yang, Eun Young Lee, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Seo Yeon Baik, Seung-Hwan Lee, Jae Hyoung Cho, In Young Choi, Hyeon Woo Yim, Bong-Yun Cha
    Diabetes & Metabolism Journal.2017; 41(3): 187.     CrossRef
  • Does Weight Gain Associated with Thiazolidinedione Use Negatively Affect Cardiometabolic Health?
    Ki Dong Ko, Kyoung Kon Kim, Kyu Rae Lee
    Journal of Obesity & Metabolic Syndrome.2017; 26(2): 102.     CrossRef
  • Clinical Characteristics and Outcome of Acute Heart Failure in Korea: Results from the Korean Acute Heart Failure Registry (KorAHF)
    Sang Eun Lee, Hae-Young Lee, Hyun-Jai Cho, Won-Seok Choe, Hokon Kim, Jin Oh Choi, Eun-Seok Jeon, Min-Seok Kim, Jae-Joong Kim, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Hyun-Young Park, Myeon
    Korean Circulation Journal.2017; 47(3): 341.     CrossRef
  • Factors that could explain the increasing prevalence of type 2 diabetes among adults in a Canadian province: a critical review and analysis
    Véronique Thibault, Mathieu Bélanger, Emilie LeBlanc, Lise Babin, Stuart Halpine, Beverly Greene, Michelina Mancuso
    Diabetology & Metabolic Syndrome.2016;[Epub]     CrossRef
  • Association of Waist-Height Ratio with Diabetes Risk: A 4-Year Longitudinal Retrospective Study
    Yoon Jeong Son, Jihyun Kim, Hye-Jeong Park, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
    Endocrinology and Metabolism.2016; 31(1): 127.     CrossRef
  • Social Networking Services-Based Communicative Care for Patients with Diabetes Mellitus in Korea
    Hun-Sung Kim, Yoo Jeong, Sun Baik, So Yang, Tong Kim, Hyunah Kim, Hyunyong Lee, Seung-Hwan Lee, Jae Cho, In-Young Choi, Kun-Ho Yoon
    Applied Clinical Informatics.2016; 07(03): 899.     CrossRef
  • Relative and combined effects of socioeconomic status and diabetes on mortality
    Nam Hoon Kim, Tae Joon Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Yousung Park, Sin Gon Kim
    Medicine.2016; 95(30): e4403.     CrossRef
  • Recent Advances in Diagnostic Strategies for Diabetic Peripheral Neuropathy
    Jong Chul Won, Tae Sun Park
    Endocrinology and Metabolism.2016; 31(2): 230.     CrossRef
  • Patterns of Diagnosis and Risk Factors for Type 2 Diabetes in Women with a History of Gestational Diabetes Mellitus
    Mi Jin Choi, Chae Weon Chung
    Perspectives in Nursing Science.2016; 13(1): 17.     CrossRef
  • Mortality and causes of death in a national sample of type 2 diabetic patients in Korea from 2002 to 2013
    Yu Mi Kang, Ye-Jee Kim, Joong-Yeol Park, Woo Je Lee, Chang Hee Jung
    Cardiovascular Diabetology.2016;[Epub]     CrossRef
  • Health Performance and Challenges in Korea: a Review of the Global Burden of Disease Study 2013
    Yo Han Lee, Seok-Jun Yoon, Arim Kim, Hyeyoung Seo, Seulki Ko
    Journal of Korean Medical Science.2016; 31(Suppl 2): S114.     CrossRef
  • Pharmacological Management of Obesity in Patients with Type 2 Diabetes: An Update
    Eun Ju Lee, Tae Nyun Kim
    The Korean Journal of Obesity.2016; 25(3): 121.     CrossRef
  • Current status of managing diabetes mellitus in Korea
    Kyoung Hwa Ha, Dae Jung Kim
    The Korean Journal of Internal Medicine.2016; 31(5): 845.     CrossRef
  • Hyperglycemia at presentation is associated with in hospital mortality in non-diabetic patient with organophosphate poisoning
    Jeong Mi Moon, Byeong Jo Chun, Yong Soo Cho
    Clinical Toxicology.2016; 54(3): 252.     CrossRef
  • Effectiveness of Web-Based Interventions for Managing Diabetes in Korea
    Jee Young Joo
    CIN: Computers, Informatics, Nursing.2016; 34(12): 587.     CrossRef
  • Hypoglycemia and Health Costs
    Yong-ho Lee, Gyuri Kim, Eun Seok Kang
    The Journal of Korean Diabetes.2016; 17(1): 11.     CrossRef
  • Letter: Characterization of Patients with Type 2 Diabetes according to Body Mass Index: Korea National Health and Nutrition Examination Survey from 2007 to 2011 (Endocrinol Metab 2015;30:514-21, Dong-Hwa Lee et al.)
    Eun-Hee Cho
    Endocrinology and Metabolism.2016; 31(2): 345.     CrossRef
  • Gender-Specific Associations between Socioeconomic Status and Psychological Factors and Metabolic Syndrome in the Korean Population: Findings from the 2013 Korean National Health and Nutrition Examination Survey
    Kyoung Im Cho, Bo Hyun Kim, Hyung Gon Je, Jae Sik Jang, Yong Hyun Park
    BioMed Research International.2016; 2016: 1.     CrossRef
  • Need for Diabetes Prevention Study
    Ja Young Jeon, Dae Jung Kim
    The Journal of Korean Diabetes.2015; 16(3): 161.     CrossRef
  • Diabetes in Asians
    Eun-Jung Rhee
    Endocrinology and Metabolism.2015; 30(3): 263.     CrossRef
  • Epidemiologic Characteristics of Dyslipidemia in Korea
    Kyoung Hwa Ha, Hyuk-Sang Kwon, Dae Jung Kim
    Journal of Lipid and Atherosclerosis.2015; 4(2): 93.     CrossRef
Close layer
Miscellaneous
Sarcopenia and Muscle Aging: A Brief Overview
Tam Dao, Alexander E. Green, Yun A Kim, Sung-Jin Bae, Ki-Tae Ha, Karim Gariani, Mi-ra Lee, Keir J. Menzies, Dongryeol Ryu
Endocrinol Metab. 2020;35(4):716-732.   Published online December 23, 2020
DOI: https://doi.org/10.3803/EnM.2020.405
  • 21,574 View
  • 1,225 Download
  • 70 Web of Science
  • 76 Crossref
AbstractAbstract PDFPubReader   ePub   
The world is facing the new challenges of an aging population, and understanding the process of aging has therefore become one of the most important global concerns. Sarcopenia is a condition which is defined by the gradual loss of skeletal muscle mass and function with age. In research and clinical practice, sarcopenia is recognized as a component of geriatric disease and is a current target for drug development. In this review we define this condition and provide an overview of current therapeutic approaches. We further highlight recent findings that describe key pathophysiological phenotypes of this condition, including alterations in muscle fiber types, mitochondrial function, nicotinamide adenine dinucleotide (NAD+) metabolism, myokines, and gut microbiota, in aged muscle compared to young muscle or healthy aged muscle. The last part of this review examines new therapeutic avenues for promising treatment targets. There is still no accepted therapy for sarcopenia in humans. Here we provide a brief review of the current state of research derived from various mouse models or human samples that provide novel routes for the development of effective therapeutics to maintain muscle health during aging.

Citations

Citations to this article as recorded by  
  • Interactions between mitochondrial dysfunction and other hallmarks of aging: Paving a path toward interventions that promote healthy old age
    Yuan Li, Laura Berliocchi, Zhiquan Li, Lene Juel Rasmussen
    Aging Cell.2024;[Epub]     CrossRef
  • Circulating lumican as a potential biomarker for osteosarcopenia in older adults
    So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
    Bone.2024; 179: 116959.     CrossRef
  • D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?
    Jan Homolak, Ana Babic Perhoc, Davor Virag, Ana Knezovic, Jelena Osmanovic Barilar, Melita Salkovic‐Petrisic
    BioEssays.2024;[Epub]     CrossRef
  • Dark tea extract attenuates age-related muscle loss by suppressing oxidative stress and inflammation in skeletal muscle of mice
    Ahyoung Yoo, Hyo Deok Seo, Jeong-Hoon Hahm, Chang Hwa Jung, Jiyun Ahn, Tae Youl Ha
    Journal of Functional Foods.2024; 112: 105980.     CrossRef
  • Moderate dietary restriction delays the onset of age-associated sarcopenia in Caenorhabditis elegans due to reduced myosin UNC-54 degradation
    Sobha Tumbapo, Adam Strudwick, Jana J. Stastna, Simon C. Harvey, Marieke J. Bloemink
    Mechanisms of Ageing and Development.2024; 217: 111900.     CrossRef
  • Trop T, hand grip strength and waist circumference as markers of sarcopenic obesity in postmenopausal women: An analytical cross-sectional study
    Sheetal Sarangi, Arul Senghor K. A., Vinodhini V. M.
    Indian Journal of Physiology and Pharmacology.2024; 0: 1.     CrossRef
  • Temporal Muscle Thickness: A Practical Approximation for Assessing Muscle Mass in Older Adults
    Miguel German Borda, Jonathan Patricio Baldera, Jessica Samuelsson, Anna Zettergren, Lina Rydén, Eric Westman, Mario Ulises Pérez-Zepeda, Silke Kern, Luis Carlos Venegas, Gustavo Duque, Ingmar Skoog, Dag Aarsland
    Journal of the American Medical Directors Association.2024;[Epub]     CrossRef
  • Undernutrition in obese older adults by fat percentage
    Meris Esra Bozkurt, Tugba Erdogan, Nezahat Muge Catikkas, Serdar Ozkok, Cihan Kilic, Gulistan Bahat, Mehmet Akif Karan
    Aging Clinical and Experimental Research.2024;[Epub]     CrossRef
  • The BET inhibitor JQ1 targets fat metabolism and counteracts obesity
    Claudia Fornelli, Alessia Sofia Cento, Lorenzo Nevi, Raffaella Mastrocola, Gustavo Ferreira Alves, Giuseppina Caretti, Massimo Collino, Fabio Penna
    Journal of Advanced Research.2024;[Epub]     CrossRef
  • Effects of Rosemary Extract on C2C12 Myoblast Differentiation and 5-Aminoimidazole-4-carboxamide Ribonucleoside (AICAR)-Induced Muscle Cell Atrophy
    Jun Ho Lee, Jung Yoon Jang, Young Hoon Kwon, Seung Ho Lee, Cheol Park, Yung Hyun Choi, Nam Deuk Kim
    Applied Sciences.2023; 13(2): 986.     CrossRef
  • Relationship between asthma and sarcopenia in the elderly: a nationwide study from the KNHANES
    Ha-Kyeong Won, Yewon Kang, Jin An, Ji-Hyang Lee, Woo-Jung Song, Hyouk-Soo Kwon, You Sook Cho, Hee-Bom Moon, Il-Young Jang, Tae-Bum Kim
    Journal of Asthma.2023; 60(2): 304.     CrossRef
  • A Lignan from Alnus japonica Activates Myogenesis and Alleviates Dexamethasone-induced Myotube Atrophy
    Hyejin Lee, Ji Hye Jeong, Seung Hwan Hwang, Sung Hum Yeon, Jae-Ha Ryu
    Planta Medica.2023; 89(05): 484.     CrossRef
  • A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity
    Gregory Livshits, Alexander Kalinkovich
    Ageing Research Reviews.2023; 86: 101852.     CrossRef
  • Facilitators and Barriers of Tai Chi Practice in Community-Dwelling Older Adults: Qualitative Study
    Yan Du, Penny Roberts, Wei Liu
    Asian/Pacific Island Nursing Journal.2023; 7: e42195.     CrossRef
  • Extract of Alnus japonica prevents dexamethasone-induced muscle atrophy in mice
    Hyejin Lee, Kyeong Seon Lee, Ji Hye Jeong, Ji Soo Yoon, Seung Hwan Hwang, Sang-Yoon Kim, Sung Hum Yeon, Jae-Ha Ryu
    Journal of Functional Foods.2023; 101: 105419.     CrossRef
  • Axis “microbiota - muscle”
    A. N. Zavyalova, V. P. Novikova, P. D. Ignatova
    Experimental and Clinical Gastroenterology.2023; (11): 60.     CrossRef
  • Comparison of the effects of commercial whey protein and native whey protein on muscle strength and muscle protein synthesis in rats
    Jiyun Kim, Eun Woo Jeong, Youjin Baek, Gwang-woong Go, Hyeon Gyu Lee
    Food Science and Biotechnology.2023; 32(3): 381.     CrossRef
  • Prevalence of sarcopenia in patients with COPD through different musculature measurements: An updated meta-analysis and meta-regression
    Jie He, Hezhi Li, Jun Yao, Yan Wang
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • Proteome network analysis of skeletal muscle in lignan-enriched nutmeg extract-fed aged mice
    Je-Ho Lee, Hyuno Kang, Gyung-Tae Ban, Beom Kyu Kim, JaeHyeon Lee, Heeyoun Hwang, Hwa-Seung Yoo, Kun Cho, Jong-Soon Choi
    Journal of Analytical Science and Technology.2023;[Epub]     CrossRef
  • Aging, Physical Exercise, Telomeres, and Sarcopenia: A Narrative Review
    David Hernández-Álvarez, Juana Rosado-Pérez, Graciela Gavia-García, Taide Laurita Arista-Ugalde, Itzen Aguiñiga-Sánchez, Edelmiro Santiago-Osorio, Víctor Manuel Mendoza-Núñez
    Biomedicines.2023; 11(2): 598.     CrossRef
  • Genetic and Probiotic Characteristics of Urolithin A Producing Enterococcus faecium FUA027
    Mengjie Xia, Shuting Mu, Yaowei Fang, Xiaomeng Zhang, Guang Yang, Xiaoyue Hou, Fuxiang He, Yaling Zhao, Yichen Huang, Wei Zhang, Juan Shen, Shu Liu
    Foods.2023; 12(5): 1021.     CrossRef
  • A nomogram to predict the risk of sarcopenia in older people
    Guangjiao Yin, Juanjuan Qin, Ziwei Wang, Fang Lv, Xujun Ye
    Medicine.2023; 102(16): e33581.     CrossRef
  • Air pollution weaken your muscle? Evidence from a cross-sectional study on sarcopenia in central China
    Faxue Zhang, Tianzhou Li, Bingbing Chen, Nuoya Li, Xupeng Zhang, Shijie Zhu, Gaichan Zhao, Xiaowei Zhang, TingTing Ma, Fang Zhou, Hao Liu, Wei Zhu
    Ecotoxicology and Environmental Safety.2023; 258: 114962.     CrossRef
  • Safety and Risk Factors of Needle Thoracentesis Decompression in Tension Pneumothorax in Patients over 75 Years Old
    Yanhu Wang, Lei Wang, Cheng Chen, Yifan Que, Yinyi Li, Jiang Luo, Ming Yin, Miao Lv, Guogang Xu, Anita Pye
    Canadian Respiratory Journal.2023; 2023: 1.     CrossRef
  • Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives
    Spencer Cholak, James W. Saville, Xing Zhu, Alison M. Berezuk, Katharine S. Tuttle, Omid Haji-Ghassemi, Francisco J. Alvarado, Filip Van Petegem, Sriram Subramaniam
    Structure.2023; 31(7): 790.     CrossRef
  • Sarcopenia and Cardiovascular Diseases
    Abdulla A. Damluji, Maha Alfaraidhy, Noora AlHajri, Namit N. Rohant, Manish Kumar, Christina Al Malouf, Samira Bahrainy, Min Ji Kwak, Wayne B. Batchelor, Daniel E. Forman, Michael W. Rich, James Kirkpatrick, Ashok Krishnaswami, Karen P. Alexander, Gary Ge
    Circulation.2023; 147(20): 1534.     CrossRef
  • Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases
    Byung Soo Kong, Changhan Lee, Young Min Cho
    Diabetes & Metabolism Journal.2023; 47(3): 315.     CrossRef
  • Pathogenesis, Intervention, and Current Status of Drug Development for Sarcopenia: A Review
    Jung Yoon Jang, Donghwan Kim, Nam Deuk Kim
    Biomedicines.2023; 11(6): 1635.     CrossRef
  • Polyamines and Physical Activity in Musculoskeletal Diseases: A Potential Therapeutic Challenge
    Letizia Galasso, Annalisa Cappella, Antonino Mulè, Lucia Castelli, Andrea Ciorciari, Alessandra Stacchiotti, Angela Montaruli
    International Journal of Molecular Sciences.2023; 24(12): 9798.     CrossRef
  • Non-alcoholic fatty liver disease in women – Current knowledge and emerging concepts
    Pei Chia Eng, Roberta Forlano, Tricia Tan, Pinelopi Manousou, Waljit S. Dhillo, Chioma Izzi-Engbeaya
    JHEP Reports.2023; 5(10): 100835.     CrossRef
  • Effects of polyphenols and their metabolites on age-related diseases
    Chouari Zhor, Lounis Wafaa, Imen Ghzaiel, Khadidja Kessas, Amira Zarrouk, Mohamed Ksila, Taoufik Ghrairi, Norbert Latruffe, Olfa Masmoudi-Kouki, Adil El Midaoui, Dominique Vervandier-Fasseur, Mohamed Hammami, Gérard Lizard, Anne Vejux, Omar Kharoubi
    Biochemical Pharmacology.2023; 214: 115674.     CrossRef
  • Circadian regulation in aging: Implications for spaceflight and life on earth
    Deeksha Malhan, Britt Schoenrock, Müge Yalçin, Dieter Blottner, Angela Relόgio
    Aging Cell.2023;[Epub]     CrossRef
  • Mitochondria-associated programmed cell death as a therapeutic target for age-related disease
    Thanh T. Nguyen, Shibo Wei, Thu Ha Nguyen, Yunju Jo, Yan Zhang, Wonyoung Park, Karim Gariani, Chang-Myung Oh, Hyeon Ho Kim, Ki-Tae Ha, Kyu Sang Park, Raekil Park, In-Kyu Lee, Minho Shong, Riekelt H. Houtkooper, Dongryeol Ryu
    Experimental & Molecular Medicine.2023; 55(8): 1595.     CrossRef
  • Normative reference values, determinants and regression equations for the incremental shuttle walk test (ISWT) in healthy Asian population aged 21 to 80 years
    Muhammad Zulhaziq Bin Azman, Katherin S. Huang, Wei Jun Koh, Sarah S. Leong, Benjamin Ong, Johanna L. Soon, Sherman W. Tan, Melissa Y. Chan, Mingxing Yang, Meredith T. Yeung, Hans-Peter Kubis
    PLOS ONE.2023; 18(9): e0291132.     CrossRef
  • Influence of sarcopenia on postoperative complications in patients undergoing autologous microsurgical breast reconstruction: an inverse probability of treatment weighting analysis
    Seung-Jun Lee, Yun-Jung Yang, Dong-Won Lee, Seung-Yong Song, Dae-Hyun Lew, Eun-Jung Yang
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Stromal vascular fraction in the treatment of myositis
    S. Gandolfi, B. Pileyre, L. Drouot, I. Dubus, I. Auquit-Auckbur, J. Martinet
    Cell Death Discovery.2023;[Epub]     CrossRef
  • Multidisciplinary approach to sarcopenia: a narrative review
    Wook Tae Park, Oog-Jin Shon, Gi Beom Kim
    Journal of Yeungnam Medical Science.2023; 40(4): 352.     CrossRef
  • Metallosis after Hip Arthroplasty Damages Skeletal Muscle: A Case Report
    Roberto Bonanni, Lorenzo Abbondante, Ida Cariati, Elena Gasbarra, Umberto Tarantino
    Geriatrics.2023; 8(5): 92.     CrossRef
  • Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men
    Antoneta Granic, Karen Suetterlin, Tea Shavlakadze, Miranda D. Grounds, Avan A. Sayer
    Clinical Science.2023; 137(22): 1721.     CrossRef
  • Predicted lean body mass trajectories, and cancer risk and cancer‐specific and all‐cause mortality: A prospective cohort study
    Chenan Liu, Qingsong Zhang, Tong Liu, Qi Zhang, Mengmeng Song, Guotian Ruan, Shiqi Lin, Ziwen Wang, Xin Zheng, Yue Chen, Heyang Zhang, Yizhong Ge, Hailun Xie, Jinyu Shi, Li Deng, Shouling Wu, Hanping Shi
    Journal of Cachexia, Sarcopenia and Muscle.2023; 14(6): 2916.     CrossRef
  • Cancer Cachexia: New Insights and Future Directions
    Claudia Raluca Mariean, Oana Mirela Tiucă, Alexandru Mariean, Ovidiu Simion Cotoi
    Cancers.2023; 15(23): 5590.     CrossRef
  • Development and comparative analysis of protein-polyphenol-fibre bars as nutritional supplements suitable for healthy senior consumers
    M. Jolji, B. Pecsenye, Z. Mposula, A. Aleya, T. Kiss, E. Mathé
    Acta Universitatis Sapientiae, Alimentaria.2023; 16(1): 103.     CrossRef
  • Zebrafish as an Emerging Model for Sarcopenia: Considerations, Current Insights, and Future Directions
    Santiago Callegari, Foad Mirzaei, Lila Agbaria, Sanobar Shariff, Burhan Kantawala, Desmond Moronge, Brian M. O. Ogendi
    International Journal of Molecular Sciences.2023; 24(23): 17018.     CrossRef
  • Laboratory markers of osteosarcopenic obesity
    O. V. Gritsenko, O. V. Gruzdeva, G. A. Chumakova, O. L. Barbarash
    Russian Journal of Cardiology.2023; 28(12): 5563.     CrossRef
  • Higher Plasma Stromal Cell-Derived Factor 1 Is Associated with Lower Risk for Sarcopenia in Older Asian Adults
    Sunghwan Ji, Kyunggon Kim, So Jeong Park, Jin Young Lee, Hee-Won Jung, Hyun Ju Yoo, Il-Young Jang, Eunju Lee, Ji Yeon Baek, Beom-Jun Kim
    Endocrinology and Metabolism.2023; 38(6): 701.     CrossRef
  • Familial Correlation and Heritability of Hand Grip Strength in Korean Adults (Korea National Health and Nutrition Examination Survey 2014 to 2019)
    Seong Hee Ahn, Eun Byeol Park, Seongha Seo, Yongin Cho, Da Hea Seo, So Hun Kim, Young Ju Suh, Seongbin Hong
    Endocrinology and Metabolism.2023; 38(6): 709.     CrossRef
  • Ageing with neuromuscular disease: Implications for a lifeworld‐led care through a humanising approach
    Louise Abildgaard Møller, Bente Martinsen, Ulla Werlauf, Pia Dreyer
    Journal of Clinical Nursing.2022; 31(17-18): 2507.     CrossRef
  • CT-derived relationship between low relative muscle mass and bone damage in patients with multiple myeloma undergoing stem cells transplantation
    Alberto Stefano Tagliafico, Federica Rossi, Bianca Bignotti, Lorenzo Torri, Alessandro Bonsignore, Liliana Belgioia, Alida Domineitto
    The British Journal of Radiology.2022;[Epub]     CrossRef
  • A new paradigm in sarcopenia: Cognitive impairment caused by imbalanced myokine secretion and vascular dysfunction
    Danbi Jo, Gwangho Yoon, Oh Yoen Kim, Juhyun Song
    Biomedicine & Pharmacotherapy.2022; 147: 112636.     CrossRef
  • Sarcopenia Is a Cause and Consequence of Metabolic Dysregulation in Aging Humans: Effects of Gut Dysbiosis, Glucose Dysregulation, Diet and Lifestyle
    James W. Daily, Sunmin Park
    Cells.2022; 11(3): 338.     CrossRef
  • Change of Computed Tomography-Based Body Composition after Adrenalectomy in Patients with Pheochromocytoma
    Yousun Ko, Heeryoel Jeong, Seungwoo Khang, Jeongjin Lee, Kyung Won Kim, Beom-Jun Kim
    Cancers.2022; 14(8): 1967.     CrossRef
  • Acute bioenergetic insulin sensitivity of skeletal muscle cells: ATP-demand-provoked glycolysis contributes to stimulation of ATP supply
    Rosie A. Donnell, Jane E. Carré, Charles Affourtit
    Biochemistry and Biophysics Reports.2022; 30: 101274.     CrossRef
  • The Hunt Is On! In Pursuit of the Ideal Stem Cell Population for Cartilage Regeneration
    T. Mark Campbell, F. Jeffrey Dilworth, David S. Allan, Guy Trudel
    Frontiers in Bioengineering and Biotechnology.2022;[Epub]     CrossRef
  • Decreased Serum Level of Sclerostin in Older Adults with Sarcopenia
    Seong Hee Ahn, Hee-Won Jung, Eunju Lee, Ji Yeon Baek, Il-Young Jang, So Jeong Park, Jin Young Lee, Eunah Choi, Yun Sun Lee, Seongbin Hong, Beom-Jun Kim
    Endocrinology and Metabolism.2022; 37(3): 487.     CrossRef
  • Effects of Muscles on Bone Metabolism—with a Focus on Myokines
    Beom-Jun Kim
    Annals of Geriatric Medicine and Research.2022; 26(2): 63.     CrossRef
  • Sclerostin as a Putative Myokine in Sarcopenia
    Hyon-Seung Yi
    Endocrinology and Metabolism.2022; 37(3): 430.     CrossRef
  • Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging
    Naoki Ito, Ai Takatsu, Hiromi Ito, Yuka Koike, Kiyoshi Yoshioka, Yasutomi Kamei, Shin-ichiro Imai
    Cell Reports.2022; 40(4): 111131.     CrossRef
  • Restoration of NAD+homeostasis protects C2C12 myoblasts and mouse levator ani muscle from mechanical stress-induced damage
    Guotao Huang, Yong He, Li Hong, Min Zhou, Xiaohu Zuo, Zhihan Zhao
    Animal Cells and Systems.2022; 26(4): 192.     CrossRef
  • Machine learning-featured Secretogranin V is a circulating diagnostic biomarker for pancreatic adenocarcinomas associated with adipopenia
    Yunju Jo, Min-Kyung Yeo, Tam Dao, Jeongho Kwon, Hyon‐Seung Yi, Dongryeol Ryu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Development and Verification of a Combined Diagnostic Model for Sarcopenia with Random Forest and Artificial Neural Network
    Shangjin Lin, Cong Chen, Xiaoxi Cai, Fengjian Yang, Yongqian Fan, Rajesh Kaluri
    Computational and Mathematical Methods in Medicine.2022; 2022: 1.     CrossRef
  • Bronchial Asthma and Sarcopenia: An Upcoming Potential Interaction
    Nikolaos D. Karakousis, Ourania S. Kotsiou, Konstantinos I. Gourgoulianis
    Journal of Personalized Medicine.2022; 12(10): 1556.     CrossRef
  • Suppressive Effects of Turmeric Extract on Muscle Atrophy in Dexamethasone-Treated Mice and Myotubes
    Kyohei Furukawa, Marika Kousaka, Huijuan Jia, Hisanori Kato
    Nutrients.2022; 14(19): 3979.     CrossRef
  • Normative reference values and regression equations to predict the 6-minute walk distance in the Asian adult population aged 21–80 years
    Meredith T. Yeung, Melissa Y. Chan, Katherin S. Huang, Tian Jie Chen, Cyprian P. Chia, Meihiko M. Fong, Cherilyn S. Ho, Derek T. Koh, Mitchell J. Neo, Mark Tan
    Hong Kong Physiotherapy Journal.2022; 42(02): 111.     CrossRef
  • Food insecurity as a risk factor of sarcopenic obesity in older adults
    Diana Fonseca-Pérez, Cecilia Arteaga-Pazmiño, Claudia P. Maza-Moscoso, Sara Flores-Madrid, Ludwig Álvarez-Córdova
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Transcriptome Sequencing Analysis of circRNA in Skeletal Muscle between Fast- and Slow-Growing Chickens at Embryonic Stages
    Genxi Zhang, Jin Zhang, Pengfei Wu, Xuanze Ling, Qifan Wang, Kaizhi Zhou, Peifeng Li, Li Zhang, Hongxin Ye, Qi Zhang, Qingyu Wei, Tao Zhang, Xinglong Wang
    Animals.2022; 12(22): 3166.     CrossRef
  • Amino Acids in Cancer and Cachexia: An Integrated View
    Maurizio Ragni, Claudia Fornelli, Enzo Nisoli, Fabio Penna
    Cancers.2022; 14(22): 5691.     CrossRef
  • Determination of skeletal muscle mass by aspartate aminotransferase / alanine aminotransferase ratio, insulin and FSH in Chinese women with sarcopenia
    Mengting Yin, He Zhang, Qianhui Liu, Fei Ding, Lisha Hou, Yiping Deng, Tao Cui, Yixian Han, Yijun Chen, Chen Huang, Jirong Yue, Yong He
    BMC Geriatrics.2022;[Epub]     CrossRef
  • The inflammatory response, a mixed blessing for muscle homeostasis and plasticity
    Zineb Bouredji, Anteneh Argaw, Jérôme Frenette
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults
    Da Ae Kim, So Jeong Park, Jin Young Lee, Jeoung Hee Kim, Seungjoo Lee, Eunju Lee, Il-Young Jang, Hee-Won Jung, Jin Hoon Park, Beom-Jun Kim
    Endocrinology and Metabolism.2021; 36(2): 455.     CrossRef
  • Association of Water Intake with Hand Grip Strength in Community-Dwelling Older Adults
    Hyeonmok Kim, Sun Hee Beom, Tae Ho Kim, Beom-Jun Kim
    Nutrients.2021; 13(6): 1756.     CrossRef
  • Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics
    Jong Hyeon Yoon, Ki-Sun Kwon
    Endocrinology and Metabolism.2021; 36(3): 478.     CrossRef
  • Redox Signaling and Sarcopenia: Searching for the Primary Suspect
    Nicholas A. Foreman, Anton S. Hesse, Li Li Ji
    International Journal of Molecular Sciences.2021; 22(16): 9045.     CrossRef
  • Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor
    Jin Young Lee, Da Ae Kim, Eunah Choi, Yun Sun Lee, So Jeong Park, Beom-Jun Kim
    Endocrinology and Metabolism.2021; 36(4): 865.     CrossRef
  • Artificial‐intelligence‐driven discovery of prognostic biomarker for sarcopenia
    Heewon Chung, Yunju Jo, Dongryeol Ryu, Changwon Jeong, Seong‐Kyu Choe, Jinseok Lee
    Journal of Cachexia, Sarcopenia and Muscle.2021; 12(6): 2220.     CrossRef
  • Association between Neurologic Outcomes and Changes of Muscle Mass Measured by Brain Computed Tomography in Neurocritically Ill Patients
    Yun Im Lee, Ryoung-Eun Ko, Joonghyun Ahn, Keumhee C. Carriere, Jeong-Am Ryu
    Journal of Clinical Medicine.2021; 11(1): 90.     CrossRef
  • Computed Tomography-Derived Skeletal Muscle Radiodensity Is an Early, Sensitive Marker of Age-Related Musculoskeletal Changes in Healthy Adults
    Yeon Woo Jung, Namki Hong, Joon Chae Na, Woong Kyu Han, Yumie Rhee
    Endocrinology and Metabolism.2021; 36(6): 1201.     CrossRef
Close layer
Obesity and Metabolism
Recent Progress on Branched-Chain Amino Acids in Obesity, Diabetes, and Beyond
Md Abu Bakkar Siddik, Andrew C. Shin
Endocrinol Metab. 2019;34(3):234-246.   Published online September 26, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.3.234
  • 11,081 View
  • 245 Download
  • 74 Web of Science
  • 75 Crossref
AbstractAbstract PDFPubReader   ePub   

Branched-chain amino acids (BCAAs) are essential amino acids that are not synthesized in our body; thus, they need to be obtained from food. They have shown to provide many physiological and metabolic benefits such as stimulation of pancreatic insulin secretion, milk production, adipogenesis, and enhanced immune function, among others, mainly mediated by mammalian target of rapamycin (mTOR) signaling pathway. After identified as a reliable marker of obesity and type 2 diabetes in recent years, an increasing number of studies have surfaced implicating BCAAs in the pathophysiology of other diseases such as cancers, cardiovascular diseases, and even neurodegenerative disorders like Alzheimer's disease. Here we discuss the most recent progress and review studies highlighting both correlational and potentially causative role of BCAAs in the development of these disorders. Although we are just beginning to understand the intricate relationships between BCAAs and some of the most prevalent chronic diseases, current findings raise a possibility that they are linked by a similar putative mechanism.

Citations

Citations to this article as recorded by  
  • Branched‐Chain Amino Acid Accumulation Fuels the Senescence‐Associated Secretory Phenotype
    Yaosi Liang, Christopher Pan, Tao Yin, Lu Wang, Xia Gao, Ergang Wang, Holly Quang, De Huang, Lianmei Tan, Kun Xiang, Yu Wang, Peter B. Alexander, Qi‐Jing Li, Tso‐Pang Yao, Zhao Zhang, Xiao‐Fan Wang
    Advanced Science.2024;[Epub]     CrossRef
  • Deficiency of BCAT2-mediated branched-chain amino acid catabolism promotes colorectal cancer development
    Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2024; 1870(2): 166941.     CrossRef
  • Microbiome metabolite quantification methods enabling insights into human health and disease
    Jarrod Roach, Rohit Mital, Jacob J. Haffner, Nathan Colwell, Randy Coats, Horvey M. Palacios, Zongyuan Liu, Joseane L.P. Godinho, Monica Ness, Thilini Peramuna, Laura-Isobel McCall
    Methods.2024; 222: 81.     CrossRef
  • Branched-chain amino acids promote occurrence and development of cardiovascular disease dependent on triglyceride metabolism via activation of the mTOR/SREBP-1/betatrophin pathway
    Jie Zhang, Ziyu Liu, Yaojun Ni, Yang Yu, Fei Guo, Yanwen Lu, Xiaoqing Wang, Hairong Hao, Shayan Li, Pan Wei, Weinan Yu, Wen Hu
    Molecular and Cellular Endocrinology.2024; 584: 112164.     CrossRef
  • Heat stress reduces brown adipose tissue activity by exacerbating mitochondrial damage in type 2 diabetic mice
    Penghua Lai, Linlin Zhang, Yan Qiu, Jie Ren, Xue Sun, Ting Zhang, Liuyi Wang, Sijie Cheng, Sijia Liu, Hongli Zhuang, Daiwei Lu, Shaoliang Zhang, Huiqing Liang, Shaodong Chen
    Journal of Thermal Biology.2024; 119: 103799.     CrossRef
  • Unraveling Adipose Tissue Dysfunction: Molecular Mechanisms, Novel Biomarkers, and Therapeutic Targets for Liver Fat Deposition
    Marta Lopez-Yus, Carlos Hörndler, Sofia Borlan, Vanesa Bernal-Monterde, Jose M. Arbones-Mainar
    Cells.2024; 13(5): 380.     CrossRef
  • Microbial production of branched chain amino acids: Advances and perspectives
    Yanan Hao, Xuewei Pan, Jiajia You, Guomin Li, Meijuan Xu, Zhiming Rao
    Bioresource Technology.2024; : 130502.     CrossRef
  • Metabolic Signatures Elucidate the Effect of Body Mass Index on Type 2 Diabetes
    Qiuling Dong, Sidra Sidra, Christian Gieger, Rui Wang-Sattler, Wolfgang Rathmann, Cornelia Prehn, Jerzy Adamski, Wolfgang Koenig, Annette Peters, Harald Grallert, Sapna Sharma
    Metabolites.2023; 13(2): 227.     CrossRef
  • The Preventive Effect of Exercise and Oral Branched-Chain Amino Acid Supplementation on Obesity-Induced Brain Changes in Ldlr−/−.Leiden Mice
    Klara J. Lohkamp, Anita M. van den Hoek, Gemma Solé-Guardia, Maria Lisovets, Talissa Alves Hoffmann, Konstantina Velanaki, Bram Geenen, Vivienne Verweij, Martine C. Morrison, Robert Kleemann, Maximilian Wiesmann, Amanda J. Kiliaan
    Nutrients.2023; 15(7): 1716.     CrossRef
  • The Crosstalk between Gut Microbiota and White Adipose Tissue Mitochondria in Obesity
    Luca Colangeli, David Israel Escobar Marcillo, Valeria Simonelli, Egidio Iorio, Tommaso Rinaldi, Paolo Sbraccia, Paola Fortini, Valeria Guglielmi
    Nutrients.2023; 15(7): 1723.     CrossRef
  • Prebiotic and Probiotic Modulation of the Microbiota–Gut–Brain Axis in Depression
    Daniel E. Radford-Smith, Daniel C. Anthony
    Nutrients.2023; 15(8): 1880.     CrossRef
  • Machine learning model to predict obesity using gut metabolite and brain microstructure data
    Vadim Osadchiy, Roshan Bal, Emeran A. Mayer, Rama Kunapuli, Tien Dong, Priten Vora, Danny Petrasek, Cathy Liu, Jean Stains, Arpana Gupta
    Scientific Reports.2023;[Epub]     CrossRef
  • Insulin Resistance and Impaired Branched-Chain Amino Acid Metabolism in Alzheimer’s Disease
    Rui Liu, Lei Zhang, Hao You
    Journal of Alzheimer's Disease.2023; 93(3): 847.     CrossRef
  • Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments
    Rexiati Ruze, Tiantong Liu, Xi Zou, Jianlu Song, Yuan Chen, Ruiyuan Xu, Xinpeng Yin, Qiang Xu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Crosstalk between arginine, glutamine, and the branched chain amino acid metabolism in the tumor microenvironment
    Tanner J. Wetzel, Sheila C. Erfan, Lucas D. Figueroa, Leighton M. Wheeler, Elitsa A. Ananieva
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Stachydrine, N‐acetylornithine and trimethylamine N‐oxide levels as candidate milk biomarkers of maternal consumption of an obesogenic diet during lactation
    Pedro Castillo, Ondrej Kuda, Jan Kopecky, Catalina Amadora Pomar, Andreu Palou, Mariona Palou, Catalina Picó
    BioFactors.2023; 49(5): 1022.     CrossRef
  • Biofunctionalization of natural extracts, trends in biological activity and kinetic release
    Abraham Osiris Martínez-Olivo, Víctor Manuel Zamora-Gasga, Luis Medina-Torres, Alejandro Pérez-Larios, Sonia Guadalupe Sáyago-Ayerdi, Jorge Alberto Sánchez-Burgos
    Advances in Colloid and Interface Science.2023; 318: 102938.     CrossRef
  • Muscle Traits, Sarcopenia, and Sarcopenic Obesity: A Vitamin D Mendelian Randomization Study
    Joshua P. Sutherland, Ang Zhou, Elina Hyppönen
    Nutrients.2023; 15(12): 2703.     CrossRef
  • Bioactive Ingredients in Traditional Fermented Food Condiments: Emerging Products for Prevention and Treatment of Obesity and Type 2 Diabetes
    Alphonse Laya, Honoré Wangso, Iva Fernandes, Raphaël Djakba, Joana Oliveira, Eugenia Carvalho, Wen yi Kang
    Journal of Food Quality.2023; 2023: 1.     CrossRef
  • Sex related differences in muscle health and metabolism in chronic obstructive pulmonary disease
    Mariëlle P.K.J. Engelen, Sarah K. Kirschner, Kimberly S. Coyle, David Argyelan, Gabriel Neal, Srinivasan Dasarathy, Nicolaas E.P. Deutz
    Clinical Nutrition.2023; 42(9): 1737.     CrossRef
  • Depiction of Branched-Chain Amino Acids (BCAAs) in Diabetes with a Focus on Diabetic Microvascular Complications
    Daniela Maria Tanase, Evelina Maria Gosav, Tina Botoc, Mariana Floria, Claudia Cristina Tarniceriu, Minela Aida Maranduca, Anca Haisan, Andrei Ionut Cucu, Ciprian Rezus, Claudia Florida Costea
    Journal of Clinical Medicine.2023; 12(18): 6053.     CrossRef
  • Genetic and Lifestyle-Related Factors Influencing Serum Hyper-Propionylcarnitine Concentrations and Their Association with Metabolic Syndrome and Cardiovascular Disease Risk
    Yong-Hwa Lee, Sunmin Park
    International Journal of Molecular Sciences.2023; 24(21): 15810.     CrossRef
  • Relationship between Components, Intestinal Microbiota, and Mechanism of Hypoglycemic Effect of the Saggy Ink Cap Medicinal Mushroom (Coprinus Comatus, Agaricomycetes): A Review
    Wei Wang, Min Sun, Jinyan Yu, Xumin Ma, Chunchao Han
    International Journal of Medicinal Mushrooms.2023; 25(12): 81.     CrossRef
  • High-protein diet with excess leucine prevents inactivity-induced insulin resistance in women
    Alessandro Mangogna, Filippo Giorgio Di Girolamo, Nicola Fiotti, Pierandrea Vinci, Matteo Landolfo, Filippo Mearelli, Gianni Biolo
    Clinical Nutrition.2023; 42(12): 2578.     CrossRef
  • Exploring the functional roles of small-molecule metabolites in disease research: Recent advancements in metabolomics
    Aolei Tan, Xiaoxiao Ma
    Chinese Chemical Letters.2023; : 109276.     CrossRef
  • Toward Systems-Level Metabolic Analysis in Endocrine Disorders and Cancer
    Aliya Lakhani, Da Hyun Kang, Yea Eun Kang, Junyoung O. Park
    Endocrinology and Metabolism.2023; 38(6): 619.     CrossRef
  • Dietary intake of branched-chain amino acids in relation to general and abdominal obesity
    Farzaneh Asoudeh, Asma Salari-Moghaddam, Ammar Hassanzadeh Keshteli, Ahmad Esmaillzadeh, Peyman Adibi
    Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2022; 27(4): 1303.     CrossRef
  • Tea polyphenol – gut microbiota interactions: hints on improving the metabolic syndrome in a multi-element and multi-target manner
    Hui Ma, Yaozhong Hu, Bowei Zhang, Zeping Shao, Eugeni Roura, Shuo Wang
    Food Science and Human Wellness.2022; 11(1): 11.     CrossRef
  • First trimester metabolomics 1H-NMR study of the urinary profile predicts gestational diabetes mellitus development in obese women
    Cristina Piras, Isabella Neri, Roberta Pintus, Antonio Noto, Elisabetta Petrella, Francesca Monari, Angelica Dessì, Vassilios Fanos, Luigi Atzori, Fabio Facchinetti
    The Journal of Maternal-Fetal & Neonatal Medicine.2022; 35(25): 8275.     CrossRef
  • Exogenous isoleucine can confer browning resistance on fresh-cut potato by suppressing polyphenol oxidase activity and improving the antioxidant capacity
    Zan Meng, Tong Wang, Aman Ullah Malik, Qingguo Wang
    Postharvest Biology and Technology.2022; 184: 111772.     CrossRef
  • Impact of thermal treatment and fermentation by lactic acid bacteria on sorghum metabolite changes, their antioxidant and antidiabetic activities
    Fred Kwame Ofosu, Fazle Elahi, Eric Banan-Mwine Daliri, Sang-Ik Han, Deog-Hwan Oh
    Food Bioscience.2022; 45: 101502.     CrossRef
  • Infant intakes of human milk branched chain amino acids are negatively associated with infant growth and influenced by maternal body mass index
    Jessica L. Saben, Clark R. Sims, Lindsay Pack, Renny Lan, Elisabet Børsheim, Aline Andres
    Pediatric Obesity.2022;[Epub]     CrossRef
  • Roux-En-Y Gastric Bypass (RYGB) Surgery during High Liquid Sucrose Diet Leads to Gut Microbiota-Related Systematic Alterations
    Laimdota Zizmare, Christina N. Boyle, Sabrina Buss, Sandrine Louis, Laura Kuebler, Ketki Mulay, Ralf Krüger, Lara Steinhauer, Isabelle Mack, Manuel Rodriguez Gomez, Kristina Herfert, Yvonne Ritze, Christoph Trautwein
    International Journal of Molecular Sciences.2022; 23(3): 1126.     CrossRef
  • Omics Analyses of Intestinal Microbiota and Hypothalamus Clock Genes in Circadian Disturbance Model Mice Fed with Green Tea Polyphenols
    Yuting Zhang, Lu Cheng, Yanan Liu, Ruilin Zhang, Zufang Wu, Kejun Cheng, Xin Zhang
    Journal of Agricultural and Food Chemistry.2022; 70(6): 1890.     CrossRef
  • Age, Sex, Body Mass Index, Diet and Menopause Related Metabolites in a Large Homogeneous Alpine Cohort
    Vinicius Verri Hernandes, Nikola Dordevic, Essi Marjatta Hantikainen, Baldur Bragi Sigurdsson, Sigurður Vidir Smárason, Vanessa Garcia-Larsen, Martin Gögele, Giulia Caprioli, Ilaria Bozzolan, Peter P. Pramstaller, Johannes Rainer
    Metabolites.2022; 12(3): 205.     CrossRef
  • α-ketoisocaproic acid promotes ER stress through impairment of autophagy, thereby provoking lipid accumulation and insulin resistance in murine preadipocytes
    Tae Jun Park, Seung Yeon Park, Hyun Jung Lee, A.M. Abd El-Aty, Ji Hoon Jeong, Tae Woo Jung
    Biochemical and Biophysical Research Communications.2022; 603: 109.     CrossRef
  • The associations of serum valine with mild cognitive impairment and Alzheimer’s disease
    Yong-lan Xiong, Joseph Therriault, Shu-jiang Ren, Xiao-jun Jing, Hua Zhang
    Aging Clinical and Experimental Research.2022; 34(8): 1807.     CrossRef
  • The Critical Role of the Branched Chain Amino Acids (BCAAs) Catabolism-Regulating Enzymes, Branched-Chain Aminotransferase (BCAT) and Branched-Chain α-Keto Acid Dehydrogenase (BCKD), in Human Pathophysiology
    Aikaterini Dimou, Vasilis Tsimihodimos, Eleni Bairaktari
    International Journal of Molecular Sciences.2022; 23(7): 4022.     CrossRef
  • Obesity, exercise training, and BCAA supplementation: All that glitters (may not be) gold
    Stephen J. Carter, Emily B. Long, Cydne A. Perry
    Obesity.2022; 30(6): 1139.     CrossRef
  • Effects of serum branched-chain amino acids on nonalcoholic fatty liver disease and subsequent cardiovascular disease
    Fei Guo, Rui Chen, Linghui Kong, Pan Wei, Ziyu Liu, Xiaoqing Wang, Hairong Hao, Yanwen Lu, Wen Hu
    Hepatology International.2022; 16(6): 1424.     CrossRef
  • Advances in multi-omics study of biomarkers of glycolipid metabolism disorder
    Xinyi Fang, Runyu Miao, Jiahua Wei, Haoran Wu, Jiaxing Tian
    Computational and Structural Biotechnology Journal.2022; 20: 5935.     CrossRef
  • Targeted Metabolomics Revealed a Sex-Dependent Signature for Metabolic Syndrome in the Mexican Population
    Berenice Palacios-González, Guadalupe León-Reyes, Berenice Rivera-Paredez, Isabel Ibarra-González, Marcela Vela-Amieva, Yvonne N. Flores, Samuel Canizales-Quinteros, Jorge Salmerón, Rafael Velázquez-Cruz
    Nutrients.2022; 14(18): 3678.     CrossRef
  • Case report: NAFLD and maple syrup urine disease: Is there an interplay between branched-chain amino acids and fructose consumption?
    Helena Moreira-Silva, Sandra Ferreira, Manuela Almeida, Isabel Gonçalves, Maria Augusta Cipriano, J. R. Vizcaíno, Ermelinda Santos-Silva, Esmeralda Gomes-Martins
    Frontiers in Pediatrics.2022;[Epub]     CrossRef
  • A self-assembled leucine polymer sensitizes leukemic stem cells to chemotherapy by inhibiting autophagy in acute myeloid leukemia
    Xi Xu, Jian Wang, Tong Tong, Wenwen Zhang, Jin Wang, Weiwei Ma, Shunqing Wang, Dunhua Zhou, Jun Wu, Linjia Jiang, Meng Zhao
    Haematologica.2022; 107(10): 2344.     CrossRef
  • Effect of dietary protein content shift on aging in elderly rats by comprehensive quantitative score and metabolomics analysis
    Wenxuan Zheng, Ruiding Li, Yang Zhou, Fengcui Shi, Yao Song, Yanting Liao, Fan Zhou, Xiaohua Zheng, Jingwen Lv, Quanyang Li
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men
    M. H. Sayda, M. H. Abdul Aziz, N. Gharahdaghi, D. J. Wilkinson, P. L. Greenhaff, B. E. Phillips, K. Smith, I. Idris, P. J. Atherton
    Scientific Reports.2022;[Epub]     CrossRef
  • Dietary Protein and Amino Acid Deficiency Inhibit Pancreatic Digestive Enzyme mRNA Translation by Multiple Mechanisms
    Maria Dolors Sans, Stephen J. Crozier, Nancy L. Vogel, Louis G. D’Alecy, John A. Williams
    Cellular and Molecular Gastroenterology and Hepatology.2021; 11(1): 99.     CrossRef
  • Isoleucine increases muscle mass through promoting myogenesis and intramyocellular fat deposition
    Shuge Liu, Yunmei Sun, Rui Zhao, Yingqian Wang, Wanrong Zhang, Weijun Pang
    Food & Function.2021; 12(1): 144.     CrossRef
  • Serum metabolomics study of women with different annual decline rates of anti-Müllerian hormone: an untargeted gas chromatography–mass spectrometry-based study
    Nazanin Moslehi, Parvin Mirmiran, Rezvan Marzbani, Hassan Rezadoost, Mehdi Mirzaie, Fereidoun Azizi, Fahimeh Ramezani Tehrani
    Human Reproduction.2021; 36(3): 721.     CrossRef
  • Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID‐19
    Aradhana Mariam Philips, Nooruddin Khan
    Obesity Reviews.2021;[Epub]     CrossRef
  • The chemical mechanisms of the enzymes in the branched-chain amino acids biosynthetic pathway and their applications
    Yan-Fei Liang, Zi-Xian Long, Ya-Jian Zhang, Cai-Yun Luo, Le-Tian Yan, Wen-Yun Gao, Heng Li
    Biochimie.2021; 184: 72.     CrossRef
  • Plasma Metabolomic Profiling in 1391 Subjects with Overweight and Obesity from the SPHERE Study
    Gianfranco Frigerio, Chiara Favero, Diego Savino, Rosa Mercadante, Benedetta Albetti, Laura Dioni, Luisella Vigna, Valentina Bollati, Angela Cecilia Pesatori, Silvia Fustinoni
    Metabolites.2021; 11(4): 194.     CrossRef
  • Sarcopenic Obesity and Amino Acids: Concord Health and Ageing in Men Project
    David G Le Couteur, David J Handelsman, Fiona Stanaway, Louise M Waite, Fiona M Blyth, Vasi Naganathan, Robert G Cumming, Vasant Hirani, Rafael de Cabo
    The Journals of Gerontology: Series A.2021; 76(6): 1000.     CrossRef
  • Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition
    Nathalie Kliemann, Vivian Viallon, Neil Murphy, Rebecca J. Beeken, Joseph A. Rothwell, Sabina Rinaldi, Nada Assi, Eline H. van Roekel, Julie A. Schmidt, Kristin Benjaminsen Borch, Claudia Agnoli, Ann H. Rosendahl, Hanna Sartor, José María Huerta, Anne Tjø
    BMC Medicine.2021;[Epub]     CrossRef
  • Plasma Amino Acids and Residual Hypertriglyceridemia in Diabetic Patients Under Statins: Two Independent Cross-Sectional Hospital-Based Cohorts
    Shuang Wang, Yun-Feng Cao, Xiao-Yu Sun, Mo Hong, Zhong-Ze Fang, Hui-Huan Luo, Huan Sun, Ping Yang
    Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
  • Identification of Metabolic Phenotypes in Young Adults with Obesity by 1H NMR Metabolomics of Blood Serum
    Khin Thandar Htun, Jie Pan, Duanghathai Pasanta, Montree Tungjai, Chatchanok Udomtanakunchai, Sirirat Chancharunee, Siriprapa Kaewjaeng, Hong Joo Kim, Jakrapong Kaewkhao, Suchart Kothan
    Life.2021; 11(6): 574.     CrossRef
  • A Metabolic Pattern in Healthy Subjects Given a Single Dose of Metformin: A Metabolomics Approach
    Lina A. Dahabiyeh, Muhammad Mujammami, Tawfiq Arafat, Hicham Benabdelkamel, Assim A. Alfadda, Anas M. Abdel Rahman
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism
    Gagandeep Mann, Stephen Mora, Glory Madu, Olasunkanmi A. J. Adegoke
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes
    David Z. Pan, Zong Miao, Caroline Comenho, Sandhya Rajkumar, Amogha Koka, Seung Hyuk T. Lee, Marcus Alvarez, Dorota Kaminska, Arthur Ko, Janet S. Sinsheimer, Karen L. Mohlke, Nicholas Mancuso, Linda Liliana Muñoz-Hernandez, Miguel Herrera-Hernandez, Maria
    Genome Medicine.2021;[Epub]     CrossRef
  • Antidiabetic Effect of Noodles Containing Fermented Lettuce Extracts
    Soon Yeon Jeong, Eunjin Kim, Ming Zhang, Yun-Seong Lee, Byeongjun Ji, Sun-Hee Lee, Yu Eun Cheong, Soon-Il Yun, Young-Soo Kim, Kyoung Heon Kim, Min Sun Kim, Hyun Soo Chun, Sooah Kim
    Metabolites.2021; 11(8): 520.     CrossRef
  • Targeted and Untargeted Mass Spectrometry Reveals the Impact of High-Fat Diet on Peripheral Amino Acid Regulation in a Mouse Model of Alzheimer’s Disease
    Amelia L. Taylor, Don E. Davis, Simona G. Codreanu, Fiona E. Harrison, Stacy D. Sherrod, John A. McLean
    Journal of Proteome Research.2021; 20(9): 4405.     CrossRef
  • The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study
    Raimo Jauhiainen, Jagadish Vangipurapu, Annamaria Laakso, Teemu Kuulasmaa, Johanna Kuusisto, Markku Laakso
    The Journal of Clinical Endocrinology & Metabolism.2021; 106(12): 3448.     CrossRef
  • Serum Metabolite Profile Associated with Sex-Dependent Visceral Adiposity Index and Low Bone Mineral Density in a Mexican Population
    Berenice Palacios-González, Guadalupe León-Reyes, Berenice Rivera-Paredez, Isabel Ibarra-González, Marcela Vela-Amieva, Yvonne N. Flores, Samuel Canizales-Quinteros, Jorge Salmerón, Rafael Velázquez-Cruz
    Metabolites.2021; 11(9): 604.     CrossRef
  • Branched chain amino acids—friend or foe in the control of energy substrate turnover and insulin sensitivity?
    Elżbieta Supruniuk, Ewa Żebrowska, Adrian Chabowski
    Critical Reviews in Food Science and Nutrition.2021; : 1.     CrossRef
  • Diet Effects on Cerebrospinal Fluid Amino Acids Levels in Adults with Normal Cognition and Mild Cognitive Impairment
    Kate J. Russin, K. Sreekumaran Nair, Thomas J. Montine, Laura D. Baker, Suzanne Craft
    Journal of Alzheimer's Disease.2021; 84(2): 843.     CrossRef
  • QSHY Granules Promote White Adipose Tissue Browning and Correct BCAAs Metabolic Disorder in NAFLD Mice
    Binbin Zhang, Mingzhu Ni, Xiaojing Li, Qiaohong Liu, Yiyang Hu, Yu Zhao
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 4241.     CrossRef
  • The Changes in Endogenous Metabolites in Hyperlipidemic Rats Treated with Herbal Mixture Containing Lemon, Apple Cider, Garlic, Ginger, and Honey
    Azliana Abu Bakar Sajak, Azrina Azlan, Faridah Abas, Hazilawati Hamzah
    Nutrients.2021; 13(10): 3573.     CrossRef
  • Integration of Transcriptome and Metabolome Provides Unique Insights to Pathways Associated With Obese Breast Cancer Patients
    Mohammed A. Hassan, Kaltoom Al-Sakkaf, Mohammed Razeeth Shait Mohammed, Ashraf Dallol, Jaudah Al-Maghrabi, Alia Aldahlawi, Sawsan Ashoor, Mabrouka Maamra, Jiannis Ragoussis, Wei Wu, Mohammad Imran Khan, Abdulrahman L. Al-Malki, Hani Choudhry
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Omics Biomarkers in Obesity: Novel Etiological Insights and Targets for Precision Prevention
    Krasimira Aleksandrova, Caue Egea Rodrigues, Anna Floegel, Wolfgang Ahrens
    Current Obesity Reports.2020; 9(3): 219.     CrossRef
  • Why Are Branched-Chain Amino Acids Increased in Starvation and Diabetes?
    Milan Holeček
    Nutrients.2020; 12(10): 3087.     CrossRef
  • Differential gene signature in adipose tissue depots of growth hormone transgenic mice
    Silvana Duran‐Ortiz, Jonathan A. Young, Adam Jara, Elizabeth A. Jensen, Reetobrata Basu, Edward O. List, Yanrong Qian, John J. Kopchick, Darlene E. Berryman
    Journal of Neuroendocrinology.2020;[Epub]     CrossRef
  • Prognostic Role of Serum Amino Acids in Head and Neck Cancer
    Gabriella Cadoni, Luca Giraldi, Carlo Chiarla, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Stefano Settimi, Jacopo Galli, Gaetano Paludetti, Dario Arzani, Stefania Boccia, Ivo Giovannini, Giovanni Almadori, Leigh A. Madden
    Disease Markers.2020; 2020: 1.     CrossRef
  • Lipid changes in the metabolome of a single case study with maple syrup urine disease (MSUD) after five days of improved diet adherence of controlled branched-chain amino acids (BCAA)
    Teresa D. Douglas, L. Kristin Newby, Julie Eckstrand, Douglas Wixted, Rani H. Singh
    Molecular Genetics and Metabolism Reports.2020; 25: 100651.     CrossRef
  • Branched chain amino acids, aging and age-related health
    David G. Le Couteur, Samantha M. Solon-Biet, Victoria C. Cogger, Rosilene Ribeiro, Rafael de Cabo, David Raubenheimer, Gregory J. Cooney, Stephen J. Simpson
    Ageing Research Reviews.2020; 64: 101198.     CrossRef
  • Branched-chain ketoacid overload inhibits insulin action in the muscle
    Dipsikha Biswas, Khoi T. Dao, Angella Mercer, Andrew M. Cowie, Luke Duffley, Yassine El Hiani, Petra C. Kienesberger, Thomas Pulinilkunnil
    Journal of Biological Chemistry.2020; 295(46): 15597.     CrossRef
Close layer
Thyroid
Effects of Increased Iodine Intake on Thyroid Disorders
Xin Sun, Zhongyan Shan, Weiping Teng
Endocrinol Metab. 2014;29(3):240-247.   Published online September 25, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.3.240
  • 10,166 View
  • 130 Download
  • 68 Web of Science
  • 73 Crossref
AbstractAbstract PDFPubReader   

Iodine is a micronutrient essential for the production of thyroid hormones. Iodine deficiency is the most common cause of preventable mental impairment worldwide. Universal salt iodization (USI) has been introduced in many countries as a cost-effective and sustainable way to eliminate iodine deficiency disorders for more than 25 years. Currently, the relationship between USI and iodine excess has attracted more attention. Iodine excess can lead to hypothyroidism and autoimmune thyroiditis, especially for susceptible populations with recurring thyroid disease, the elderly, fetuses, and neonates. Nationwide USI was introduced in China in 1996. This review focused on the effects of iodine excess worldwide and particularly in China.

Citations

Citations to this article as recorded by  
  • Comparison of effects of potassium iodide and potassium chloride on structure and physicochemical properties of proteins
    Fuge Niu, Yi Gao, Xinyu Yan, Huabin Liao, Zhe Li, Yanren Cao, Mengdi Zhao, Beibei Wang, Jiao Yu, Weichun Pan
    Journal of Molecular Liquids.2024; 395: 123844.     CrossRef
  • Micronutrients throughout the Life Cycle: Needs and Functions in Health and Disease
    Mohit Kumar, Devesh Kumar, Ankita Sharma, Shivam Bhadauria, Anil Thakur, Amit Bhatia
    Current Nutrition & Food Science.2024; 20(1): 62.     CrossRef
  • Relationship Between Urinary Iodine Concentration and the Prevalence of Thyroid Nodules and Subclinical Hypothyroidism
    Huachao Zhu, Pu Chen, Xi Ding, Yanru Zhao
    Hormone and Metabolic Research.2024;[Epub]     CrossRef
  • Thyroid-Stimulating Hormone Levels within the Trimester-Specific Reference Intervals Are Correlated with Non–High-Density Lipoprotein Cholesterol and Remnant Cholesterol Concentrations in Pregnant Women
    Guocheng Wang, Feng Jin, Limin Xie, Xiaofen Zhang, Yawei Zhang, Xin Ni, Wei Li, Guojun Zhang
    Laboratory Medicine.2023; 54(5): 449.     CrossRef
  • Factors associated with inadequate urinary iodine concentration among pregnant women in Mbeya region Tanzania.
    Tedson Lukindo, Ray Masumo, Adam Hancy, Sauli E. John, Heavenlight A. Paulo, Abraham Sanga, Ramadhan Noor, Fatoumata Lankoande, Elifatio Towo, Germana H. Leyna, Gemma Bridge, Raman Bedi
    F1000Research.2023; 10: 858.     CrossRef
  • Iodine status and its association with prevalence of thyroid diseases in adults from Jiangxi Province, China
    Di-en Yan, Lei Hu, Yun-feng Shen, Xiao-yang Lai, Mei-ying Zhang, Min Zhou, Chao Chen, Mei-mei Liu, Li-ting Wu, Li-qun Liu, Qi-wei Fan, Wen-lan Min, Si-cong Wan, Fang Zou, Jing Li, Xia Cai, Shui-hong Lei, Yan Xiong, Ya Yang, Rong Yu, Wei-wei Gao, Ying Zhan
    Endocrine.2023; 82(2): 335.     CrossRef
  • Autoimmune thyroid status in subclinical thyroid disorders in patients attending a tertiary care center in Nepal: a hospital-based cross-sectional study
    Vijay Kumar Sharma, Apeksha Niraula, Eans Tara Tuladhar, Aseem Bhattarai, Mithileshwer Raut, Raju Kumar Dubey, Sujata Baidya, Naresh Parajuli
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • INFLUÊNCIA DA NUTRIÇÃO NO MANEJO DO HIPOTIREOIDISMO
    Karine Rodrigues da Silva Neumann , Isadora Neres Silva, Elaine Cristina Rocha Oliveira, Taís Cristina Macêdo de Carvalho
    Revista Saúde Dos Vales.2023;[Epub]     CrossRef
  • Relationship between Thyroid CT Density, Volume, and Future TSH Elevation: A 5-Year Follow-Up Study
    Tomohiro Kikuchi, Shouhei Hanaoka, Takahiro Nakao, Yukihiro Nomura, Takeharu Yoshikawa, Md Ashraful Alam, Harushi Mori, Naoto Hayashi
    Life.2023; 13(12): 2303.     CrossRef
  • The relationship between urinary iodine concentration and papillary thyroid cancer: A systematic review and meta-analysis
    Xueqi Zhang, Fan Zhang, Qiuxian Li, Renaguli Aihaiti, Chuyao Feng, Deshi Chen, Xu Zhao, Weiping Teng
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • The impact of the micronutrient iodine in health and diseases
    Ma. Cecilia Opazo, Irenice Coronado-Arrázola, Omar P. Vallejos, Rodrigo Moreno-Reyes, Carlos Fardella, Lorena Mosso, Alexis M. Kalergis, Susan M. Bueno, Claudia A. Riedel
    Critical Reviews in Food Science and Nutrition.2022; 62(6): 1466.     CrossRef
  • Halogens in Seaweeds: Biological and Environmental Significance
    Hanan Al-Adilah, Martin C. Feiters, Lucy J. Carpenter, Puja Kumari, Carl J. Carrano, Dhia Al-Bader, Frithjof C. Küpper
    Phycology.2022; 2(1): 132.     CrossRef
  • Solid sorbents for gaseous iodine capture and their conversion into stable waste forms
    R. Pénélope, L. Campayo, M. Fournier, A. Gossard, A. Grandjean
    Journal of Nuclear Materials.2022; 563: 153635.     CrossRef
  • Secular Trends in the Prevalence of and Disability-Adjusted Life Years Due to Common Micronutrient Deficiencies in China From 1990 to 2019: An Age-Period-Cohort Study and Joinpoint Analysis
    Haiying Chen, Jinxin Lu, Yongze Li
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Iodine Concentrations in Conventional and Organic Milk in the Northeastern U.S.
    Nobumitsu Sakai, Ola Yetunde Esho, Motoko Mukai
    Dairy.2022; 3(2): 211.     CrossRef
  • Effect of iodine restriction on short-term changes in thyroid function in patients with subclinical hypothyroidism
    Obin Kwon, Dong Yeob Shin, Eun Jig Lee
    Journal of Nutrition and Health.2022; 55(2): 250.     CrossRef
  • Excessive iodine in iodized household salt in Nepal
    Basant Giri, Shishir Pandey, Sadiksha Shakya, Bhanu Bhakta Neupane, Krishna Prasad Kandel, Chandradip Kumar Yadav, Ram Prabodh Yadav, Bishnu Prasad Neupane, Rajendra Bahadur GC, Prem Singh Saud, Meghraj Yonjan
    Annals of the New York Academy of Sciences.2022; 1514(1): 166.     CrossRef
  • Factors associated with inadequate urinary iodine concentration among pregnant women in Mbeya region Tanzania.
    Tedson Lukindo, Ray Masumo, Adam Hancy, Sauli E. John, Heavenlight A. Paulo, Abraham Sanga, Ramadhan Noor, Fatoumata Lankoande, Elifatio Towo, Germana H. Leyna, Gemma Bridge, Raman Bedi
    F1000Research.2022; 10: 858.     CrossRef
  • Iodine nutrition and papillary thyroid cancer
    Xueqi Zhang, Fan Zhang, Qiuxian Li, Chuyao Feng, Weiping Teng
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Thyroid function disorders
    Mirjana Stojković
    Arhiv za farmaciju.2022; 72(5): 429.     CrossRef
  • Serum T3 Level and Duration of Minimum Maintenance Dose Therapy Predict Relapse in Methimazole-Treated Graves Disease
    Yotsapon Thewjitcharoen, Krittadhee Karndumri, Waralee Chatchomchuan, Sriurai Porramatikul, Sirinate Krittiyawong, Ekgaluck Wanothayaroj, Siriwan Butadej, Soontaree Nakasatien, Rajata Rajatanavin, Thep Himathongkam
    Journal of the Endocrine Society.2021;[Epub]     CrossRef
  • Factors influencing the reference interval of thyroid‐stimulating hormone in healthy adults: A systematic review and meta‐analysis
    Dongyang Xing, Delong Liu, Ri Li, Qi Zhou, Jiancheng Xu
    Clinical Endocrinology.2021; 95(3): 378.     CrossRef
  • The Iodine Status and Prevalence of Thyroid Disorders Among Women of Childbearing Age in China: National Cross-sectional Study
    Yongze Li, Zhongyan Shan, Weiping Teng
    Endocrine Practice.2021; 27(10): 1028.     CrossRef
  • Environmental and human iodine and selenium status: lessons from Gilgit-Baltistan, North-East Pakistan
    Saeed Ahmad, Elizabeth H. Bailey, Muhammad Arshad, Sher Ahmed, Michael J. Watts, Alex G. Stewart, Scott D. Young
    Environmental Geochemistry and Health.2021; 43(11): 4665.     CrossRef
  • Factors associated with inadequate urinary iodine concentration among pregnant women in Mbeya region Tanzania.
    Tedson Lukindo, Ray Masumo, Adam Hancy, Sauli E. John, Heavenlight A. Paulo, Abraham Sanga, Ramadhan Noor, Fatoumata Lankoande, Elifatio Towo, Germana H. Leyna, Gemma Bridge, Raman Bedi
    F1000Research.2021; 10: 858.     CrossRef
  • Association between Iodine Intake, Thyroid Function, and Papillary Thyroid Cancer: A Case-Control Study
    Kyungsik Kim, Sun Wook Cho, Young Joo Park, Kyu Eun Lee, Dong-Wook Lee, Sue K. Park
    Endocrinology and Metabolism.2021; 36(4): 790.     CrossRef
  • Age‐specific thyrotropin references decrease over‐diagnosis of hypothyroidism in elderly patients in iodine‐excessive areas
    Yingchai Zhang, Yu Sun, Zhiwei He, Shuhang Xu, Chao Liu, Yongze Li, Zhongyan Shan, Weiping Teng
    Clinical Endocrinology.2021;[Epub]     CrossRef
  • Dietary Micronutrients from Zygote to Senility: Updated Review of Minerals’ Role and Orchestration in Human Nutrition throughout Life Cycle with Sex Differences
    Mohamed A. Farag, Samia Hamouda, Suzan Gomaa, Aishat A. Agboluaje, Mohamad Louai M. Hariri, Shimaa Mohammad Yousof
    Nutrients.2021; 13(11): 3740.     CrossRef
  • Епідеміологія автоімунного тиреоїдиту
    V.I. Кravchenko, О.А. Тоvkay, О.V. Rakov, М.D. Тronko
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2021; 17(2): 136.     CrossRef
  • Association between urinary sodium levels and iodine status in Korea
    Jonghwa Ahn, Jang Ho Lee, Jiwoo Lee, Ji Yeon Baek, Eyun Song, Hye-Seon Oh, Mijin Kim, Suyeon Park, Min Ji Jeon, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Won Gu Kim
    The Korean Journal of Internal Medicine.2020; 35(2): 392.     CrossRef
  • Is heart disease a risk factor for low dementia test battery scores in older persons with Down syndrome? Exploratory, pilot study, and commentary
    Maire E. Percy, Walter J. Lukiw
    International Journal of Developmental Disabilities.2020; 66(1): 22.     CrossRef
  • A cross-sectional research of iodine status of pregnant women in Chongqing, south-west China
    Ning Yao, Chunbei Zhou, Jun Xie, Shuang Zhou
    Public Health Nutrition.2020; 23(5): 769.     CrossRef
  • The Diverse Upper Reference Limits of Serum Thyroid-Stimulating Hormone on the Same Platform for Pregnant Women in China
    Guocheng Wang, Guojun Zhang
    Laboratory Medicine.2020; 51(4): 416.     CrossRef
  • Efficacy and Safety of Long-Term Universal Salt Iodization on Thyroid Disorders: Epidemiological Evidence from 31 Provinces of Mainland China
    Yongze Li, Di Teng, Jianming Ba, Bing Chen, Jianling Du, Lanjie He, Xiaoyang Lai, Xiaochun Teng, Xiaoguang Shi, Yanbo Li, Haiyi Chi, Eryuan Liao, Chao Liu, Libin Liu, Guijun Qin, Yingfen Qin, Huibiao Quan, Bingyin Shi, Hui Sun, Xulei Tang, Nanwei Tong, Gu
    Thyroid.2020; 30(4): 568.     CrossRef
  • High prevalence of TPO-Abs and subclinical hypothyroidism in iodine-sufficient pregnant women in Northern Algeria
    Samira Akdader-Oudahmane, Zohra Hamouli-Saïd, Michael B. Zimmermann, Hanane Kherrab, Said Azzoug, Djamila Meskine
    Journal of Trace Elements in Medicine and Biology.2020; 61: 126533.     CrossRef
  • An Inverse Relationship Between Iodine Intake and Thyroid Antibodies: A National Cross-Sectional Survey in Mainland China
    Di Teng, Wenqing Yang, Xiaoguang Shi, Yongze Li, Jianming Ba, Bing Chen, Jianling Du, Lanjie He, Xiaoyang Lai, Yanbo Li, Haiyi Chi, Eryuan Liao, Chao Liu, Libin Liu, Guijun Qin, Yingfen Qin, Huibiao Quan, Bingyin Shi, Hui Sun, Xulei Tang, Nanwei Tong, Gui
    Thyroid.2020; 30(11): 1656.     CrossRef
  • Therapeutic Effects of Combination Regimens Including Methimazole on Graves Hyperthyroidism: A Network Meta-Analysis of Randomized Controlled Trials
    Maorong Wang, Yerong Yu
    Endocrine Practice.2020; 26(6): 675.     CrossRef
  • The change in the clinical presentation of Graves’ disease: a 30 years retrospective survey in an academic Brazilian tertiary center
    Wanesa Pinto, João H. Romaldini, Nicolas Perini, Roberto B. Santos, Danilo Villagelin
    Archives of Endocrinology and Metabolism.2020;[Epub]     CrossRef
  • Association between Urinary Iodine Concentration and Thyroid Nodules in Adults: A Cross-Sectional Study in China
    Hui Sun, Hanyu Wang, Xiaolan Lian, Chao Liu, Bingyin Shi, Lixin Shi, Nanwei Tong, Shu Wang, Jianping Weng, Jiajun Zhao, Jiaoyue Zhang, Juan Zheng, Xiang Hu, Yunxia Tu, Li Yu, Zhongyan Shan, Weiping Teng, Lulu Chen, Ali Abbara
    BioMed Research International.2020; 2020: 1.     CrossRef
  • The effect of intake of sausages fortified with β-CD-I2 complex on iodine status and thyroid function: A preliminary study
    Maksym Polumbryk, Victor Kravchenko, Vasyl Pasichnyi, Chrystyna Omelchenko, Irina Pachitskaya
    Journal of Trace Elements in Medicine and Biology.2019; 51: 159.     CrossRef
  • Association between Iodine Nutrition Status and Thyroid Disease-Related Hormone in Korean Adults: Korean National Health and Nutrition Examination Survey VI (2013–2015)
    Kim, Kwon, Kim, Hong, Park
    Nutrients.2019; 11(11): 2757.     CrossRef
  • Association Between Thyroid Nodules and Volume and Metabolic Syndrome in an Iodine-Adequate Area: A Large Community-Based Population Study
    Yue Su, Yan-ling Zhang, Meng Zhao, Hai-qing Zhang, Xu Zhang, Qing-bo Guan, Chun-xiao Yu, Shan-shan Shao, Jin Xu
    Metabolic Syndrome and Related Disorders.2019; 17(4): 217.     CrossRef
  • Analytical evaluation of the new Seal Autoanalyzer 3 High Resolution for urinary iodine determination
    Valentina Vidranski, Maja Franceschi, Dražena Krilić, Tomislav Jukić, Ivan Mihaljević, Zvonko Kusić
    Biochemia medica.2019; 29(2): 394.     CrossRef
  • Increased Incidence Rate of Hypothyroidism After Iodine Fortification in Denmark: A 20-Year Prospective Population-Based Study
    Mads Petersen, Nils Knudsen, Allan Carlé, Stig Andersen, Torben Jørgensen, Hans Perrild, Lars Ovesen, Lone Banke Rasmussen, Betina Heinsbæk Thuesen, Inge Bülow Pedersen
    The Journal of Clinical Endocrinology & Metabolism.2019; 104(5): 1833.     CrossRef
  • Relationship of gender and age on thyroid hormone parameters in a large Chinese population
    Xinxin Chen, Xulei Zheng, Zhaojun Ding, Yang Su, Shu Wang, Bin Cui, Zhen Xie
    Archives of Endocrinology and Metabolism.2019;[Epub]     CrossRef
  • Sex differences in the association between thyroid-stimulating hormone levels and depressive symptoms among the general population with normal free T4 levels
    San Lee, Sarah Soyeon Oh, Eun-Cheol Park, Sung-In Jang
    Journal of Affective Disorders.2019; 249: 151.     CrossRef
  • Reference intervals of thyroid hormones in a previously iodine-deficient area in Darfur, Sudan
    Nagi I. Ali, Abdullah O. Alamoudi, Ishag Adam
    Therapeutic Advances in Endocrinology and Metabolism.2018; 9(9): 293.     CrossRef
  • Highly sensitive electrochemical detection of iodate based on glassy carbon electrode modified with iridium oxide
    Yanna Lazarova, Ivan Shterev, Totka Dodevska
    Monatshefte für Chemie - Chemical Monthly.2018; 149(11): 1955.     CrossRef
  • Acute Delirium in a Hypothyroid Patient Precipitated by Iodine Supplements Use
    Gaby S. Gil, Bradford W. Smith, Jose R. Guerra, William T. Williams
    American Journal of Therapeutics.2018; 25(6): e717.     CrossRef
  • Iodine Deficiency in Zhejiang Pregnant Women in the Context of Universal Salt Iodization Programme
    Zhifang Wang, Mingluan Xing, Wenming Zhu, Guangming Mao, Zhe Mo, Yuanyang Wang, Zhijian Chen, Xiaoming Lou, Shichang Xia, Xiaofeng Wang
    Scientific Reports.2018;[Epub]     CrossRef
  • Age- and gender-specific reference intervals of TSH and free T4 in an iodine-replete area: Data from Korean National Health and Nutrition Examination Survey IV (2013–2015)
    So Young Park, Hae In Kim, Hyun-Kyung Oh, Tae Hyuk Kim, Hye Won Jang, Jae Hoon Chung, Myung-Hee Shin, Sun Wook Kim, Sun Y Lee
    PLOS ONE.2018; 13(2): e0190738.     CrossRef
  • Age-specific reference interval of serum TSH levels is high in adolescence in an iodine excess area: Korea national health and nutrition examination survey data
    Hyemi Kwon, Won Gu Kim, Min Ji Jeon, Minkyu Han, Mijin Kim, Suyeon Park, Tae Yong Kim, Young Kee Shong, Won Bae Kim
    Endocrine.2017; 57(3): 445.     CrossRef
  • Urinary iodine levels and dairy consumption in pre-school children in Southwest Asturias (Spain)
    Esther Arbesú Fernández, María Haydee Serrano Peraza, Hans Abdón Eguia Angeles, César Oliver Sotelo García, Claude Henrry Saint Jean, Nache Ismael Musa Martín
    Anales de Pediatría (English Edition).2017; 87(1): 18.     CrossRef
  • Association of iodized salt with goiter prevalence in Chinese populations: a continuity analysis over time
    Zhen Liang, Chen Xu, Yong-Jun Luo
    Military Medical Research.2017;[Epub]     CrossRef
  • Yodurias y consumo de lácteos en preescolares del Área Suroccidental de Asturias
    Esther Arbesú Fernández, M. Haydee Serrano Peraza, Hans Abdón Eguia Angeles, César Oliver Sotelo García, Claude Henrry Saint Jean, Nache Ismael Musa Martín
    Anales de Pediatría.2017; 87(1): 18.     CrossRef
  • Role of medical resource level in iodine deficiency disorder
    Chen Xu, Zhen Liang, Yong-Jun Luo
    Military Medical Research.2017;[Epub]     CrossRef
  • Strong association of relatively low and extremely excessive iodine intakes with thyroid cancer in an iodine-replete area
    Hye Jeong Kim, Na Kyung Kim, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh, Myung Hi Yoo, Yong-Ki Min, Sun Wook Kim, Jae Hoon Chung
    European Journal of Nutrition.2017; 56(3): 965.     CrossRef
  • Excessive Iodine Intake and Thyrotropin Reference Interval: Data from the Korean National Health and Nutrition Examination Survey
    Min Ji Jeon, Won Gu Kim, Hyemi Kwon, Mijin Kim, Suyeon Park, Hye-Seon Oh, Minkyu Han, Tae Yong Kim, Young Kee Shong, Won Bae Kim
    Thyroid.2017; 27(7): 967.     CrossRef
  • Metabolic syndrome is associated with an increased incidence of subclinical hypothyroidism – A Cohort Study
    Chia-Hsuin Chang, Yi-Chun Yeh, James L. Caffrey, Shyang-Rong Shih, Lee-Ming Chuang, Yu-Kang Tu
    Scientific Reports.2017;[Epub]     CrossRef
  • Associations between thyroid dysfunction and developmental status in children with excessive iodine status
    Inger Aakre, Tor A. Strand, Khalil Moubarek, Ingrid Barikmo, Sigrun Henjum, Hiroyoshi Ariga
    PLOS ONE.2017; 12(11): e0187241.     CrossRef
  • Vitamin D deficiency affects thyroid autoimmunity and dysfunction in iodine-replete area: Korea national health and nutrition examination survey
    Mijin Kim, Eyun Song, Hye-Seon Oh, Suyeon Park, Hyemi Kwon, Min Ji Jeon, Won Gu Kim, Won Bae Kim, Young Kee Shong, Tae Yong Kim
    Endocrine.2017; 58(2): 332.     CrossRef
  • Thyroid Function Status in Indian Adult Nonpregnant Females in Ranchi, India
    Nandita Hazra, Sarvinder Singh, Binay Mitra, Bhaskar Shahbabu
    Indian journal of Medical Biochemistry.2017; 21(1): 25.     CrossRef
  • Iodine Status and Prevalence of Thyroid Disorders After Introduction of Mandatory Universal Salt Iodization for 16 Years in China: A Cross-Sectional Study in 10 Cities
    Zhongyan Shan, Lulu Chen, Xiaolan Lian, Chao Liu, Bingyin Shi, Lixin Shi, Nanwei Tong, Shu Wang, Jianping Weng, Jiajun Zhao, Xiaochun Teng, Xiaohui Yu, Yaxin Lai, Weiwei Wang, Chenyan Li, Jinyuan Mao, Yongze Li, Chenling Fan, Weiping Teng
    Thyroid.2016; 26(8): 1125.     CrossRef
  • Iodine nutrition status and thyroid disorders: a cross-sectional study from the Xinjiang Autonomous Region of China
    Y Guo, J Zynat, Z Xu, X Wang, R Osiman, H Zhao, A Tuhuti, M Abdunaimu, H Wang, X Jin, S Xing
    European Journal of Clinical Nutrition.2016; 70(11): 1332.     CrossRef
  • Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary
    Xiaowen Zhang, Yaqiu Jiang, Wenqing Han, Aihua Liu, Xiaochen Xie, Cheng Han, Chenling Fan, Hong Wang, Hongmei Zhang, Shuangning Ding, Zhongyan Shan, Weiping Teng
    Biological Trace Element Research.2016; 174(2): 377.     CrossRef
  • Reference intervals of thyroid hormones in a previously iodine-deficient but presently more than adequate area of Western China: a population-based survey
    Jing Cai, Yujie Fang, Da Jing, Shaoyong Xu, Jie Ming, Bin Gao, Han Shen, Rong Zhang, Qiuhe Ji
    Endocrine Journal.2016; 63(4): 381.     CrossRef
  • Urinary Iodine Excretion among Nepalese School Children in Terai Region
    Saroj Khatiwada, Basanta Gelal, Prem Raj Shakya, Madhab Lamsal, Nirmal Baral
    The Indian Journal of Pediatrics.2016; 83(1): 15.     CrossRef
  • Usefulness of Measuring Thyroid Stimulating Antibody at the Time of Antithyroid Drug Withdrawal for Predicting Relapse of Graves Disease
    Hyemi Kwon, Won Gu Kim, Eun Kyung Jang, Mijin Kim, Suyeon Park, Min Ji Jeon, Tae Yong Kim, Jin-Sook Ryu, Young Kee Shong, Won Bae Kim
    Endocrinology and Metabolism.2016; 31(2): 300.     CrossRef
  • Evaluation of energy spectrum CT for the measurement of thyroid iodine content
    Weiguang Shao, Jingang Liu, Dianmei Liu
    BMC Medical Imaging.2016;[Epub]     CrossRef
  • Iodide Residues in Milk Vary between Iodine‐Based Teat Disinfectants
    Elizabeth A. French, Motoko Mukai, Michael Zurakowski, Bradley Rauch, Gloria Gioia, Joseph R. Hillebrandt, Mark Henderson, Ynte H. Schukken, Thomas C. Hemling
    Journal of Food Science.2016;[Epub]     CrossRef
  • Total thyroidectomy as primary surgical management for thyroid disease: surgical therapy experience from 5559 thyroidectomies in a less-developed region
    Jisheng Hu, Nan Zhao, Rui Kong, Dawei Wang, Bei Sun, Lifeng Wu
    World Journal of Surgical Oncology.2015;[Epub]     CrossRef
  • Tg in Adults as a Sensitive Biomarker of Iodine Status: A 5-Year Follow up Population Study in Different Levels of Iodine Intake Regions
    Wei Chong, Xiaoguang Shi, Zhongyan Shan, Xiaochun Teng, Di Teng, Haixia Guan, Yushu Li, Ying Jin, Xiaohui Yu, Chenling Fan, Fan Yang, Hong Dai, Yang Yu, Jia Li, Yanyan Chen, Dong Zhao, Fengnan Hu, Jinyuan Mao, Xiaolan Gu, Rong Yang, Yajie Tong, Weibo Wang
    PLOS ONE.2015; 10(8): e0135553.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
Close layer
Obesity and Metabolism
Regulation of Adipocyte Differentiation via MicroRNAs
You Hwa Son, Sojeong Ka, A Young Kim, Jae Bum Kim
Endocrinol Metab. 2014;29(2):122-135.   Published online June 26, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.2.122
  • 6,508 View
  • 99 Download
  • 74 Web of Science
  • 72 Crossref
AbstractAbstract PDFPubReader   

Adipocyte differentiation, termed adipogenesis, is a complicated process in which pluripotent mesenchymal stem cells differentiate into mature adipocytes. The process of adipocyte differentiation is tightly regulated by a number of transcription factors, hormones and signaling pathway molecules. Recent studies have demonstrated that microRNAs, which belong to small noncoding RNA species, are also involved in adipocyte differentiation. In vivo and in vitro studies have revealed that various microRNAs affect adipogenesis by targeting several adipogenic transcription factors and key signaling molecules. In this review, we will summarize the roles of microRNAs in adipogenesis and their target genes associated with each stage of adipocyte differentiation.

Citations

Citations to this article as recorded by  
  • A review of the role of epigenetic studies for intramuscular fat deposition in beef cattle
    Belete Kuraz Abebe, Jianfang Wang, Juntao Guo, Hongbao Wang, Anning Li, Linsen Zan
    Gene.2024; 908: 148295.     CrossRef
  • Transcriptome analysis of miRNAs during myoblasts adipogenic differentiation
    Chengchuang Song, Xue Fang, Qi Wang, Yaqi Chen, Bei Zhao, Yanhong Wang, Xingtang Fang, Chunlei Zhang
    Animal Biotechnology.2023; 34(4): 1406.     CrossRef
  • Advances in the regulation of adipogenesis and lipid metabolism by exosomal ncRNAs and their role in related metabolic diseases
    Cong Liu, Xilin Liu, Hong Li, Zhichen Kang
    Frontiers in Cell and Developmental Biology.2023;[Epub]     CrossRef
  • A review of the role of transcription factors in regulating adipogenesis and lipogenesis in beef cattle
    Belete Kuraz Abebe, Hongbao Wang, Anning Li, Linsen Zan
    Journal of Animal Breeding and Genetics.2023;[Epub]     CrossRef
  • Indian gooseberry and barley sprout mixture prevents obesity by regulating adipogenesis, lipogenesis, and lipolysis in C57BL/6J mice with high-fat diet-induced obesity
    Soo-Jeung Park, Jong-Lae Kim, Mi-Ryeong Park, Jong Wook Lee, Ok-Kyung Kim, Jeongmin Lee
    Journal of Functional Foods.2022; 90: 104951.     CrossRef
  • Interleukin-6 mimics insulin-dependent cellular distribution of some cytoskeletal proteins and Glut4 transporter without effect on glucose uptake in 3T3-L1 adipocytes
    Maciej Błaszczyk, Małgorzata Gajewska, Marta Dymowska, Alicja Majewska, Tomasz Domoradzki, Adam Prostek, Rafał Pingwara, Magdalena Hulanicka, Katarzyna Grzelkowska-Kowalczyk
    Histochemistry and Cell Biology.2022;[Epub]     CrossRef
  • Heat-Killed Enterococcus faecalis Prevents Adipogenesis and High Fat Diet-Induced Obesity by Inhibition of Lipid Accumulation through Inhibiting C/EBP-α and PPAR-γ in the Insulin Signaling Pathway
    Jin-Ho Lee, Keun-Jung Woo, Min-Ah Kim, Joonpyo Hong, Jihee Kim, Sun-Hong Kim, Kwon-Il Han, Masahiro Iwasa, Tack-Joong Kim
    Nutrients.2022; 14(6): 1308.     CrossRef
  • The delivery of miR-21a-5p by extracellular vesicles induces microglial polarization via the STAT3 pathway following hypoxia-ischemia in neonatal mice
    Dan-Qing Xin, Yi-Jing Zhao, Ting-Ting Li, Hong-Fei Ke, Cheng-Cheng Gai, Xiao-Fan Guo, Wen-Qiang Chen, De-Xiang Liu, Zhen Wang
    Neural Regeneration Research.2022; 17(10): 2238.     CrossRef
  • Extracellular Vesicles from Adipose Tissue Could Promote Metabolic Adaptation through PI3K/Akt/mTOR
    Jaime Delgadillo-Velázquez, Herminia Mendivil-Alvarado, Carlos Daniel Coronado-Alvarado, Humberto Astiazaran-Garcia
    Cells.2022; 11(11): 1831.     CrossRef
  • Adipocyte differentiation between obese and lean conditions depends on changes in miRNA expression
    Yerim Heo, Hyunjung Kim, Jiwon Lim, Sun Shim Choi
    Scientific Reports.2022;[Epub]     CrossRef
  • Comparison of Selected Non-Coding RNAs and Gene Expression Profiles between Common Osteosarcoma Cell Lines
    Mateusz Sikora, Katarzyna Krajewska, Klaudia Marcinkowska, Anna Raciborska, Rafał Jakub Wiglusz, Agnieszka Śmieszek
    Cancers.2022; 14(18): 4533.     CrossRef
  • Mesenchymal Stem Cell Secreted-Extracellular Vesicles are Involved in Chondrocyte Production and Reduce Adipogenesis during Stem Cell Differentiation
    Yu-Chen Tsai, Tai-Shan Cheng, Hsiu-Jung Liao, Ming-Hsi Chuang, Hui-Ting Chen, Chun-Hung Chen, Kai-Ling Zhang, Chih-Hung Chang, Po-Cheng Lin, Chi-Ying F. Huang
    Tissue Engineering and Regenerative Medicine.2022; 19(6): 1295.     CrossRef
  • Tissue and circulating microRNAs as biomarkers of response to obesity treatment strategies
    G. Catanzaro, T. Filardi, C. Sabato, A. Vacca, S. Migliaccio, S. Morano, E. Ferretti
    Journal of Endocrinological Investigation.2021; 44(6): 1159.     CrossRef
  • Benzyl Butyl Phthalate Induced Early lncRNA H19 Regulation in C3H10T1/2 Stem Cell Line
    Jian Zhang, Mahua Choudhury
    Chemical Research in Toxicology.2021; 34(1): 54.     CrossRef
  • Inhibition of preadipocyte differentiation by Lycium barbarum polysaccharide treatment in 3T3-L1 cultures
    Xiaochun Xu, Wenjuan Chen, Shukun Yu, Qian Lei, Lihong Han, Wenping Ma
    Electronic Journal of Biotechnology.2021; 50: 53.     CrossRef
  • MiR-25-3p regulates the differentiation of intramuscular preadipocytes in goat via targeting <i>KLF4</i>
    Yu Du, Yue Zhao, Yong Wang, Qingyong Meng, Jiangjiang Zhu, Yaqiu Lin
    Archives Animal Breeding.2021; 64(1): 17.     CrossRef
  • MiR-208b Regulates Rabbit Preadipocyte Proliferation and Differentiation
    Jiahao Shao, Ting Pan, Jie Wang, Tao Tang, Yanhong Li, Xianbo Jia, Songjia Lai
    Genes.2021; 12(6): 890.     CrossRef
  • Comparing the effect of cinnamaldehyde and metformin on expression of MiR320 and MiR26-b in insulin resistant 3T3L1 adipocytes
    Yousof Naghiaee, Mahmood Vakili, Mohammad Mohammadi, Azra Mohiti, Javad Mohiti-Ardakani
    Phytomedicine Plus.2021; 1(4): 100122.     CrossRef
  • Lower miR‐26a levels in breastmilk affect gene expression in adipose tissue of offspring
    Catalina A. Pomar, Francisca Serra, Andreu Palou, Juana Sánchez
    The FASEB Journal.2021;[Epub]     CrossRef
  • MicroRNA-378 regulates adipogenic differentiation in bovine intramuscular preadipocytes by targeting CaMKK2
    Dongwei Li, Heng Wang, Yongmin Li, Changqing Qu, Yunhai Zhang, Hongyu Liu, Xiaorong Zhang
    Adipocyte.2021; 10(1): 483.     CrossRef
  • miR-6315 Attenuates Methotrexate Treatment-Induced Decreased Osteogenesis and Increased Adipogenesis Potentially through Modulating TGF-β/Smad2 Signalling
    Ya-Li Zhang, Liang Liu, Yu-Wen Su, Cory J. Xian
    Biomedicines.2021; 9(12): 1926.     CrossRef
  • Inhibitory Effects of Pinostilbene on Adipogenesis in 3T3-L1 Adipocytes: A Study of Possible Mechanisms
    You Chul Chung, Chang-Gu Hyun
    International Journal of Molecular Sciences.2021; 22(24): 13446.     CrossRef
  • Regulation of Methylase METTL3 on Fat Deposition
    Gang Luo, Jialing Chen, Zhanjun Ren
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 4843.     CrossRef
  • miR-214-5p Regulating Differentiation of Intramuscular Preadipocytes in Goats via Targeting KLF12
    Yu Du, Yong Wang, Yanyan Li, Quzhe Emu, Jiangjiang Zhu, Yaqiu Lin
    Frontiers in Genetics.2021;[Epub]     CrossRef
  • Screening and identification of MicroRNAs expressed in perirenal adipose tissue during rabbit growth
    Guoze Wang, Guo Guo, Xueting Tian, Shenqiang Hu, Kun Du, Qinghai Zhang, Jingxin Mao, Xianbo Jia, Shiyi Chen, Jie Wang, Songjia Lai
    Lipids in Health and Disease.2020;[Epub]     CrossRef
  • Descending Expression of miR320 in Insulin-Resistant Adipocytes Treated with Ascending Concentrations of Metformin
    Yousof Naghiaee, Reza Didehdar, Zahra Malekpour-Dehkordi, Fatemeh Pourrajab, Javad Mohiti-Ardakani
    Biochemical Genetics.2020; 58(5): 661.     CrossRef
  • Citrus aurantium L. Dry Extracts Ameliorate Adipocyte Differentiation of 3T3-L1 Cells Exposed to TNFα by Down-Regulating miR-155 Expression
    Michele Campitelli, Antonella Desiderio, Giuseppe Cacace, Cecilia Nigro, Immacolata Prevenzano, Alessia Leone, Sonia de Simone, Pietro Campiglia, Pietro Formisano, Gregory A. Raciti, Francesco Beguinot, Claudia Miele
    Nutrients.2020; 12(6): 1587.     CrossRef
  • Metabolic Benefits of MicroRNA-22 Inhibition
    Marc Thibonnier, Christine Esau
    Nucleic Acid Therapeutics.2020; 30(2): 104.     CrossRef
  • Differentially Expressed miRNA-Gene Targets Related to Intramuscular Fat in Musculus Longissimus Dorsi of Charolais × Holstein F2-Crossbred Bulls
    Bilal Ahmad Mir, Henry Reyer, Katrin Komolka, Siriluck Ponsuksili, Christa Kühn, Steffen Maak
    Genes.2020; 11(6): 700.     CrossRef
  • MiR224-5p Inhibitor Restrains Neuronal Apoptosis by Targeting NR4A1 in the Oxygen-Glucose Deprivation (OGD) Model
    Ling-Ling Liu, Shan Qiao, Mei-Ling Wang, Huai-Kuan Wu, Yong-Xin Su, Ke-Mo Wang, Xue-Wu Liu
    Frontiers in Neuroscience.2020;[Epub]     CrossRef
  • Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways
    Melvin A. Ambele, Priyanka Dhanraj, Rachel Giles, Michael S. Pepper
    International Journal of Molecular Sciences.2020; 21(12): 4283.     CrossRef
  • MicroRNA‑449a regulates the progression of brain aging by targeting SCN2B in SAMP8 mice
    Ya‑Xin Tan, Ying Hong, Shui Jiang, Min‑Nan Lu, Shan Li, Bo Chen, Li Zhang, Tao Hu, Rui Mao, Rong Mei, Yan‑Bin Xiyang
    International Journal of Molecular Medicine.2020;[Epub]     CrossRef
  • Influence of adenovirus 36 seropositivity on the expression of adipogenic microRNAs in obese subjects
    Víctor Manríquez, Alvaro Gutierrez, Alexis Morales, Roberto Brito, Monica Pavez, Jorge Sapunar, Luis Fonseca, Víctor Molina, Eugenia Ortiz, Maria Ines Barra, Camila Reimer, Maria Charles, Constance Schneider, Alvaro Cerda
    International Journal of Obesity.2020; 44(11): 2303.     CrossRef
  • Metformin downregulates miR223 expression in insulin-resistant 3T3L1 cells and human diabetic adipose tissue
    Yousof Naghiaee, Reza Didehdar, Fatemeh Pourrajab, Masoud Rahmanian, Naeime Heiranizadeh, Azra Mohiti, Javad Mohiti-Ardakani
    Endocrine.2020; 70(3): 498.     CrossRef
  • Metabolic and energetic benefits of microRNA-22 inhibition
    Marc Thibonnier, Christine Esau, Sujoy Ghosh, Edward Wargent, Claire Stocker
    BMJ Open Diabetes Research & Care.2020; 8(1): e001478.     CrossRef
  • Bta-miR-376a Targeting KLF15 Interferes with Adipogenesis Signaling Pathway to Promote Differentiation of Qinchuan Beef Cattle Preadipocytes
    Xingyi Chen, Sayed Haidar Abbas Raza, Gong Cheng, Xinhao Ma, Jianfang Wang, Linsen Zan
    Animals.2020; 10(12): 2362.     CrossRef
  • The cross-talk between adipokines and miRNAs in health and obesity-mediated diseases
    Ahmad Ghasemi, Seyed Isaac Hashemy, Mohsen Azimi-Nezhad, Alireza Dehghani, Jafar Saeidi, Mahnaz Mohtashami
    Clinica Chimica Acta.2019; 499: 41.     CrossRef
  • MicroRNAs and long noncoding RNAs: new regulators in cell fate determination of mesenchymal stem cells
    Zixiang Wu, Shujing Liang, Wenyu Kuai, Lifang Hu, Airong Qian
    RSC Advances.2019; 9(64): 37300.     CrossRef
  • Harnessing adipogenesis to prevent obesity
    Nida Haider, Louise Larose
    Adipocyte.2019; 8(1): 98.     CrossRef
  • MiR‐127 attenuates adipogenesis by targeting MAPK4 and HOXC6 in porcine adipocytes
    Yun Gao, Yingqian Wang, Xiaochang Chen, Ying Peng, Fenfen Chen, Yulin He, Weijun Pang, Gongshe Yang, Taiyong Yu
    Journal of Cellular Physiology.2019; 234(12): 21838.     CrossRef
  • MicroRNA-425 controls lipogenesis and lipolysis in adipocytes
    Renli Qi, Jing Wang, Qi Wang, Xiaoyu Qiu, Feiyun Yang, Zuohua Liu, Jinxiu Huang
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2019; 1864(5): 744.     CrossRef
  • miRNA-7a-2-3p Inhibits Neuronal Apoptosis in Oxygen-Glucose Deprivation (OGD) Model
    Zi-Bin Zhang, Ya-Xin Tan, Qiong Zhao, Liu-Lin Xiong, Jia Liu, Fei-Fei Xu, Yang Xu, Larisa Bobrovskaya, Xin-Fu Zhou, Ting-Hua Wang
    Frontiers in Neuroscience.2019;[Epub]     CrossRef
  • IL‐1α inhibits proliferation and adipogenic differentiation of human adipose‐derived mesenchymal stem cells through NF‐κB‐ and ERK1/2‐mediated proinflammatory cytokines
    Xuerong Sun, Tangbin Zou, Changqing Zuo, Mingmeng Zhang, Benyan Shi, Zhiwen Jiang, Hongjing Cui, Xiaoxin Liao, Xiaoyi Li, Yuelian Tang, Yusheng Liu, Xinguang Liu
    Cell Biology International.2018; 42(7): 794.     CrossRef
  • MicroRNA‐224‐5p regulates adipocyte apoptosis induced by TNFα via controlling NF‐κB activation
    Renli Qi, Jinxiu Huang, Qi Wang, Hong Liu, Ruisheng Wang, Jing Wang, Feiyun Yang
    Journal of Cellular Physiology.2018; 233(2): 1236.     CrossRef
  • Potential role of microRNAs in the regulation of adipocytes liposecretion and adipose tissue physiology
    Giulia Maurizi, Lucia Babini, Lucio Della Guardia
    Journal of Cellular Physiology.2018; 233(12): 9077.     CrossRef
  • Chronic hyperinsulinemia induced miR-27b is linked to adipocyte insulin resistance by targeting insulin receptor
    Ankita Srivastava, Kripa Shankar, Muheeb Beg, Sujith Rajan, Abhishek Gupta, Salil Varshney, Durgesh Kumar, Sanchita Gupta, Raj Kumar Mishra, Anil Nilkanth Gaikwad
    Journal of Molecular Medicine.2018; 96(3-4): 315.     CrossRef
  • Bta-miR-130a/b regulates preadipocyte differentiation by targeting PPARG and CYP2U1 in beef cattle
    Xueyao Ma, Dawei Wei, Gong Cheng, Shijun Li, Li Wang, Yaning Wang, Xiaoyu Wang, Song Zhang, Hongbao Wang, Linsen Zan
    Molecular and Cellular Probes.2018; 42: 10.     CrossRef
  • Transdifferentiation of adipocytes to osteoblasts: potential for orthopaedic treatment
    Daphne P L Lin, Crispin R Dass
    Journal of Pharmacy and Pharmacology.2018; 70(3): 307.     CrossRef
  • Characterization of miRNA transcriptome profiles related to breast muscle development and intramuscular fat deposition in chickens
    Shouyi Fu, Yinli Zhao, Yuanfang Li, Guoxi Li, Yi Chen, Zhuanjian Li, Guirong Sun, Hong Li, Xiangtao Kang, Fengbin Yan
    Journal of Cellular Biochemistry.2018; 119(8): 7063.     CrossRef
  • Transcriptomic Analyses of Adipocyte Differentiation From Human Mesenchymal Stromal‐Cells (MSC)
    Antonio Casado‐Díaz, Jaouad Anter, Sören Müller, Peter Winter, José Manuel Quesada‐Gómez, Gabriel Dorado
    Journal of Cellular Physiology.2017; 232(4): 771.     CrossRef
  • Downregulated miR-29a/b/c during Contact Inhibition Stage Promote 3T3-L1 Adipogenesis by Targeting DNMT3A
    Yingjie Zhu, Guangyong Zheng, Huichao Wang, Yudong Jia, Ying Zhang, Yanfeng Tang, Wenlong Li, Yanan Fan, Xiaodong Zhang, Youwen Liu, Sanhong Liu, Makoto Kanzaki
    PLOS ONE.2017; 12(1): e0170636.     CrossRef
  • Potential miRNA involvement in the anti-adipogenic effect of resveratrol and its metabolites
    Itziar Eseberri, Arrate Lasa, Jonatan Miranda, Ana Gracia, Maria P. Portillo, Cristina Óvilo
    PLOS ONE.2017; 12(9): e0184875.     CrossRef
  • Identification and characterization of differentially expressed miRNAs in subcutaneous adipose between Wagyu and Holstein cattle
    Yuntao Guo, Xiuxiu Zhang, Wanlong Huang, Xiangyang Miao
    Scientific Reports.2017;[Epub]     CrossRef
  • Integrated analysis of mRNA and miRNA expression profiles in livers of Yimeng black pigs with extreme phenotypes for backfat thickness
    Wentong Li, Yalan Yang, Ying Liu, Shuai Liu, Xiuxiu Li, Yingping Wang, Yanmin Zhang, Hui Tang, Rong Zhou, Kui Li
    Oncotarget.2017; 8(70): 114787.     CrossRef
  • Small non coding RNAs in adipocyte biology and obesity
    Ez-Zoubir Amri, Marcel Scheideler
    Molecular and Cellular Endocrinology.2017; 456: 87.     CrossRef
  • Role of MicroRNA Regulation in Obesity-Associated Breast Cancer: Nutritional Perspectives
    Ravi Kasiappan, Dheeran Rajarajan
    Advances in Nutrition.2017; 8(6): 868.     CrossRef
  • Biomolecular features of inflammation in obese rheumatoid arthritis patients: management considerations
    Barbara Tolusso, Stefano Alivernini, Maria Rita Gigante, Gianfranco Ferraccioli, Elisa Gremese
    Expert Review of Clinical Immunology.2016; 12(7): 751.     CrossRef
  • Circulating microRNAs are deregulated in overweight/obese children: preliminary results of the I.Family study
    Giuseppe Iacomino, Paola Russo, Ilaria Stillitano, Fabio Lauria, Pasquale Marena, Wolfgang Ahrens, Pasquale De Luca, Alfonso Siani
    Genes & Nutrition.2016;[Epub]     CrossRef
  • Role of MicroRNAs in NAFLD/NASH
    Gyongyi Szabo, Timea Csak
    Digestive Diseases and Sciences.2016; 61(5): 1314.     CrossRef
  • MicroRNA‐29b promotes the adipogenic differentiation of human adipose tissue‐derived stromal cells
    Xi‐Mei Zhang, Li‐Hong Wang, Dong‐Ju Su, Dan Zhu, Qiu‐Ming Li, Mei‐Hua Chi
    Obesity.2016; 24(5): 1097.     CrossRef
  • MiR-181a-5p regulates 3T3-L1 cell adipogenesis by targeting <italic>Smad7</italic> and <italic>Tcf7l2</italic>
    Dan Ouyang, Lifeng Xu, Lihua Zhang, Dongguang Guo, Xiaotong Tan, Xiaofang Yu, Junjie Qi, Yaqiong Ye, Qihong Liu, Yongjiang Ma, Yugu Li
    Acta Biochimica et Biophysica Sinica.2016; 48(11): 1034.     CrossRef
  • Metformin-suppressed differentiation of human visceral preadipocytes: Involvement of microRNAs
    Koji Fujita, Hisakazu Iwama, Kyoko Oura, Tomoko Tadokoro, Kayo Hirose, Miwako Watanabe, Teppei Sakamoto, Akiko Katsura, Shima Mimura, Takako Nomura, Joji Tani, Hisaaki Miyoshi, Asahiro Morishita, Hirohito Yoneyama, Keiichi Okano, Yasuyuki Suzuki, Takashi
    International Journal of Molecular Medicine.2016; 38(4): 1135.     CrossRef
  • Systematic study of cis-antisense miRNAs in animal species reveals miR-3661 to target PPP2CA in human cells
    Jian Wang, Zongcheng Li, Bailong Liu, Guangnan Chen, Ningsheng Shao, Xiaomin Ying, Ya Wang
    RNA.2016; 22(1): 87.     CrossRef
  • Oxidative stress, redox regulation and diseases of cellular differentiation
    Zhi-Wei Ye, Jie Zhang, Danyelle M. Townsend, Kenneth D. Tew
    Biochimica et Biophysica Acta (BBA) - General Subjects.2015; 1850(8): 1607.     CrossRef
  • Noncoding RNAs, cytokines, and inflammation-related diseases
    José Luiz Marques-Rocha, Mirian Samblas, Fermin I. Milagro, Josefina Bressan, J. Alfredo Martínez, Amelia Marti
    The FASEB Journal.2015; 29(9): 3595.     CrossRef
  • Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes
    Jan Machal, Jan Novak, Renata Hezova, Filip Zlamal, Anna Vasku, Ondrej Slaby, Julie Bienertova-Vasku
    Genes & Nutrition.2015;[Epub]     CrossRef
  • Mitochondria-related miR-141-3p contributes to mitochondrial dysfunction in HFD-induced obesity by inhibiting PTEN
    Juan Ji, Yufeng Qin, Jing Ren, Chuncheng Lu, Rong Wang, Xiuliang Dai, Ran Zhou, Zhenyao Huang, Miaofei Xu, Minjian Chen, Wei Wu, Ling Song, Hongbing Shen, Zhibin Hu, Dengshun Miao, Yankai Xia, Xinru Wang
    Scientific Reports.2015;[Epub]     CrossRef
  • MicroRNAs in Bone Balance and Osteoporosis
    Junying Chen, Min Qiu, Ce Dou, Zhen Cao, Shiwu Dong
    Drug Development Research.2015; 76(5): 235.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
  • MicroRNA regulatory networks in human adipose tissue and obesity
    Peter Arner, Agné Kulyté
    Nature Reviews Endocrinology.2015; 11(5): 276.     CrossRef
  • Epigenomics, gestational programming and risk of metabolic syndrome
    M Desai, J K Jellyman, M G Ross
    International Journal of Obesity.2015; 39(4): 633.     CrossRef
  • Expression Profiling and Structural Characterization of MicroRNAs in Adipose Tissues of Hibernating Ground Squirrels
    Cheng-Wei Wu, Kyle K. Biggar, Kenneth B. Storey
    Genomics, Proteomics & Bioinformatics.2014; 12(6): 284.     CrossRef
Close layer
The SCAP/SREBP Pathway: A Mediator of Hepatic Steatosis
Young-Ah Moon
Endocrinol Metab. 2017;32(1):6-10.   Published online January 19, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.6
  • 7,253 View
  • 202 Download
  • 71 Web of Science
  • 70 Crossref
AbstractAbstract PDFPubReader   

Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance, obesity, and dyslipidemia. NAFLD encompasses a wide range of states from the simple accumulation of triglycerides in the hepatocytes to serious states accompanied by inflammation and fibrosis in the liver. De novo lipogenesis has been shown to be a significant factor in the development of hepatic steatosis in insulin-resistant states. Sterol regulatory element binding protein-1c (SREBP-1c) is the main transcription factor that mediates the activation of lipogenesis, and SREBP cleavage activating protein (SCAP) is required for the activation of SREBPs. Here, recent animal studies that suggest SCAP as a therapeutic target for hepatic steatosis and hypertriglyceridemia are discussed.

Citations

Citations to this article as recorded by  
  • SREBPs as the potential target for solving the polypharmacy dilemma
    Xue Wang, Yanqiu Chen, Heyu Meng, Fanbo Meng
    Frontiers in Physiology.2024;[Epub]     CrossRef
  • The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis
    Preethi Chandrasekaran, Ralf Weiskirchen
    International Journal of Molecular Sciences.2024; 25(2): 1109.     CrossRef
  • Expression and correlation analysis of silent information regulator 1 (SIRT1), sterol regulatory element-binding protein-1 (SREBP1), and pyroptosis factor in gestational diabetes mellitus
    Ning Han, Xin-yuan Chang, Zi-li Yuan, Yi-zhan Wang
    The Journal of Maternal-Fetal & Neonatal Medicine.2024;[Epub]     CrossRef
  • Uxi (Endopleura uchi (Huber) Cuatrec) bark extract mitigates HFD-induced adiposity in rats via targeting oxidative stress, and lipogenic genes expression
    Eman A.R. Abdelghffar, Zuhair M. Mohammedsaleh, Raha Osailan, Aisha Elaimi, Wafae Ouchari, Mohamed A.O. Abdelfattah, Mona F. Mahmoud, Mansour Sobeh
    Journal of Functional Foods.2024; 114: 106034.     CrossRef
  • Evolutionary analysis of buffalo sterol regulatory element-binding factor (SREBF) family genes and their affection on milk traits
    Tingzhu Ye, Jing Yuan, Sayed Haidar Abbas Raza, Tingxian Deng, Lv Yang, Muhammad Jamil Ahmad, Seyed Mahdi Hosseini, Xinxin Zhang, Muna O Alamoudi, Qwait AlGabbani, Youssef S Alghamdi, Chao Chen, Aixin Liang, Nicola M. Schreurs, Liguo Yang
    Animal Biotechnology.2023; 34(7): 2082.     CrossRef
  • Hepatic Pin1 Expression, Particularly in Nuclei, Is Increased in NASH Patients in Accordance with Evidence of the Role of Pin1 in Lipid Accumulation Shown in Hepatoma Cell Lines
    Machi Kanna, Yusuke Nakatsu, Takeshi Yamamotoya, Akifumi Kushiyama, Midori Fujishiro, Hideyuki Sakoda, Hiraku Ono, Koji Arihiro, Tomoichiro Asano
    International Journal of Molecular Sciences.2023; 24(10): 8847.     CrossRef
  • Dietary acetate promotes growth and nutrients deposition in Nile tilapia (Oreochromis niloticus) through increasing acetyl-CoA-triggered energy production
    Wen-Hao Zhou, Samwel M. Limbu, Yuan Luo, Rui-Xin Li, Jiong Ren, Fang Qiao, Mei-Ling Zhang, Zhen-Yu Du
    Aquaculture.2023; 575: 739750.     CrossRef
  • Palmitate로 유발된 비알코올성 지방간 세포 모델에서 블랙커런트 초임계 추출물의 지방증 개선효과
    수정 이, 은숙 양, 영호 김, 혜연 김, 혜란 최, 석 김, 태호 류
    Korean Journal of Food and Cookery Science.2023; 39(3): 178.     CrossRef
  • PM2.5 induced liver lipid metabolic disorders in C57BL/6J mice
    Chenxiao Zhang, Tengfei Ma, Chang Liu, Ding Ma, Jian Wang, Meng Liu, Jinjun Ran, Xueting Wang, Xiaobei Deng
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • High Gamma-Aminobutyric Acid (GABA) Oolong Tea Alleviates High-Fat Diet-Induced Metabolic Disorders in Mice
    Monthana Weerawatanakorn, Sang He, Chun-Han Chang, Yen-Chun Koh, Meei-Ju Yang, Min-Hsiung Pan
    ACS Omega.2023; 8(37): 33997.     CrossRef
  • MicroRNA-19a regulates milk fat metabolism by targeting SYT1 in bovine mammary epithelial cells
    Baojun Yu, Jiamin Liu, Zhengyun Cai, Tong Mu, Di Zhang, Xiaofang Feng, Yaling Gu, Juan Zhang
    International Journal of Biological Macromolecules.2023; 253: 127096.     CrossRef
  • SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies
    Na Li, Xiaodan Li, Yifu Ding, Xiao Liu, Karin Diggle, Tatiana Kisseleva, David A. Brenner
    Biomedicines.2023; 11(12): 3280.     CrossRef
  • Daidzein stimulates fatty acid-induced fat deposition in C2C12 myoblast cells via the G protein-coupled receptor 30 pathway
    Chengjian Zhou, Ping Li, Meihong Han, Xuejun Gao
    Animal Biotechnology.2022; 33(5): 851.     CrossRef
  • Hepatocyte steatosis inhibits hepatitis B virus secretion via induction of endoplasmic reticulum stress
    Qichuang Liu, Maoyuan Mu, Huan Chen, Guoyuan Zhang, Yanqing Yang, Jun Chu, Ying Li, Fangwan Yang, Shide Lin
    Molecular and Cellular Biochemistry.2022; 477(11): 2481.     CrossRef
  • The cholesterol pathway: impact on immunity and cancer
    Ryan J. King, Pankaj K. Singh, Kamiya Mehla
    Trends in Immunology.2022; 43(1): 78.     CrossRef
  • Hepatic retinaldehyde dehydrogenases are modulated by tocopherol supplementation in mice with hepatic steatosis
    Amanda D'Espessailles, Valeria Campos, Nevenka Juretić, Gladys S. Tapia, Paulina Pettinelli
    Nutrition.2022; 94: 111539.     CrossRef
  • CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing
    Han Zeng, Hong Qin, Meng Liao, Enze Zheng, Xiaoqing Luo, Anhua Xiao, Yiyu Li, Lin Chen, Li Wei, Lei Zhao, Xiong Z. Ruan, Ping Yang, Yaxi Chen
    Molecular Metabolism.2022; 57: 101428.     CrossRef
  • Biogenesis and Breakdown of Lipid Droplets in Pathological Conditions
    Claudio M. Fader Kaiser, Patricia S. Romano, M. Cristina Vanrell, Cristian A. Pocognoni, Julieta Jacob, Benjamín Caruso, Laura R. Delgui
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Efficacy and safety of an orally administered DGAT2 inhibitor alone or coadministered with a liver-targeted ACC inhibitor in adults with non-alcoholic steatohepatitis (NASH): rationale and design of the phase II, dose-ranging, dose-finding, randomised, pl
    Neeta B Amin, Amanda Darekar, Quentin M Anstee, Vincent Wai-Sun Wong, Frank Tacke, Manoli Vourvahis, Douglas S Lee, Michael Charlton, Naim Alkhouri, Atsushi Nakajima, Carla Yunis
    BMJ Open.2022; 12(3): e056159.     CrossRef
  • Identification of microRNA Transcriptome Involved in Bovine Intramuscular Fat Deposition
    Susan K. Duckett, Maslyn A. Greene
    Frontiers in Veterinary Science.2022;[Epub]     CrossRef
  • Camellia (Camellia oleifera bel.) seed oil reprograms gut microbiota and alleviates lipid accumulation in high fat-fed mice through the mTOR pathway
    Jing Gao, Li Ma, Jie Yin, Gang Liu, Jie Ma, SiTing Xia, SaiMing Gong, Qi Han, TieJun Li, YongZhong Chen, YuLong Yin
    Food & Function.2022; 13(9): 4977.     CrossRef
  • The Perirenal Fat Thickness Was Associated with Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus
    Yuxian Yang, Shuting Li, Yuechao Xu, Jing Ke, Dong Zhao
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 1505.     CrossRef
  • Vanadium(IV)-Chlorodipicolinate Protects against Hepatic Steatosis by Ameliorating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammation
    Yuanli Wang, Rulong Chen, Jingyi Li, Guodong Zeng, Juntao Yuan, Jingran Su, Chunyan Wu, Zhongbing Lu, Fang Zhang, Wenjun Ding
    Antioxidants.2022; 11(6): 1093.     CrossRef
  • Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis
    Satoshi Kawamura, Yuki Matsushita, Shigeyuki Kurosaki, Mizuki Tange, Naoto Fujiwara, Yuki Hayata, Yoku Hayakawa, Nobumi Suzuki, Masahiro Hata, Mayo Tsuboi, Takahiro Kishikawa, Hiroto Kinoshita, Takuma Nakatsuka, Masaya Sato, Yotaro Kudo, Yujin Hoshida, At
    Journal of Clinical Investigation.2022;[Epub]     CrossRef
  • Baicalein Prevents Fructose-Induced Hepatic Steatosis in Rats: In the Regulation of Fatty Acid De Novo Synthesis, Fatty Acid Elongation and Fatty Acid Oxidation
    Pan Li, Ruoyu Zhang, Meng Wang, Yuwei Chen, Zhiwei Chen, Xiumei Ke, Ling Zuo, Jianwei Wang
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Identification and validation of immune related core transcription factors GTF2I in NAFLD
    Minbo Zhang, Yu Zhang, Xiaoxiao Jiao, Linying Lai, Yiting Qian, Bo Sun, Wenzhuo Yang
    PeerJ.2022; 10: e13735.     CrossRef
  • Lipid-lowering effect of microencapsulated peptides from brewer's spent grain in high-sucrose diet-fed rats
    M.R. Ferreira, A.G. Garzón, M.E. Oliva, R.E. Cian, S.R. Drago, M.E. D'Alessandro
    Food Bioscience.2022; 49: 101981.     CrossRef
  • The SREBP-dependent regulation of cyclin D1 coordinates cell proliferation and lipid synthesis
    Arwa Aldaalis, Maria T. Bengoechea-Alonso, Johan Ericsson
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Targets of statins intervention in LDL-C metabolism: Gut microbiota
    ChangXin Sun, ZePing Wang, LanQing Hu, XiaoNan Zhang, JiYe Chen, ZongLiang Yu, LongTao Liu, Min Wu
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Regulation of lipid droplet (LD) formation in hepatocytes via regulation of SREBP1c by non-coding RNAs
    Shereen A. El Sobky, Nourhan K. Aboud, Nihal M. El Assaly, Injie O. Fawzy, Nada El-Ekiaby, Ahmed I. Abdelaziz
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Aspalathin-rich green rooibos tea in combination with glyburide and atorvastatin enhances lipid metabolism in a db/db mouse model
    Oelfah Patel, Christo J. F. Muller, Elizabeth Joubert, Bernd Rosenkranz, Johan Louw, Charles Awortwe
    Frontiers in Clinical Diabetes and Healthcare.2022;[Epub]     CrossRef
  • Capparis spinosa improves non-alcoholic steatohepatitis through down-regulating SREBP-1c and a PPARα-independent pathway in high-fat diet-fed rats
    Rasoul Akbari, Hamid Yaghooti, Mohammad Taha Jalali, Laya Sadat Khorsandi, Narges Mohammadtaghvaei
    BMC Research Notes.2022;[Epub]     CrossRef
  • Gypenosides counteract hepatic steatosis and intestinal barrier injury in rats with metabolic associated fatty liver disease by modulating the adenosine monophosphate activated protein kinase and Toll-like receptor 4/nuclear factor kappa B pathways
    Shuhua Shen, Kungen Wang, Yihui Zhi, Yue Dong
    Pharmaceutical Biology.2022; 60(1): 1949.     CrossRef
  • CYP51-mediated cholesterol biosynthesis is required for the proliferation of CD4+ T cells in Sjogren’s syndrome
    Junhao Yin, Jiayao Fu, Yanxiong Shao, Jiabao Xu, Hui Li, Changyu Chen, Yijie Zhao, Zhanglong Zheng, Chuangqi Yu, Lingyan Zheng, Baoli Wang
    Clinical and Experimental Medicine.2022; 23(5): 1691.     CrossRef
  • Differential TM4SF5‐mediated SIRT1 modulation and metabolic signaling in nonalcoholic steatohepatitis progression
    Jihye Ryu, Eunmi Kim, Min‐Kyung Kang, Dae‐Geun Song, Eun‐Ae Shin, Haesong Lee, Jae Woo Jung, Seo Hee Nam, Ji Eon Kim, Hye‐Jin Kim, Taekwon Son, Semi Kim, Hwi Young Kim, Jung Weon Lee
    The Journal of Pathology.2021; 253(1): 55.     CrossRef
  • Changes in Glutathione Content in Liver Diseases: An Update
    Mariapia Vairetti, Laura Giuseppina Di Pasqua, Marta Cagna, Plinio Richelmi, Andrea Ferrigno, Clarissa Berardo
    Antioxidants.2021; 10(3): 364.     CrossRef
  • Metreleptin therapy for nonalcoholic steatohepatitis: Open-label therapy interventions in two different clinical settings
    Baris Akinci, Angela Subauste, Nevin Ajluni, Nazanene H. Esfandiari, Rasimcan Meral, Adam H. Neidert, Akin Eraslan, Rita Hench, Diana Rus, Barbara Mckenna, Hero K. Hussain, Thomas L. Chenevert, Marwan K. Tayeh, Amit R. Rupani, Jeffrey W. Innis, Christos S
    Med.2021; 2(7): 814.     CrossRef
  • Prediction of Srebp-1 as a Key Target of Qing Gan San Against MAFLD in Rats via RNA-Sequencing Profile Analysis
    Bendong Yang, Jingyue Sun, Shufei Liang, Peixuan Wu, Rui Lv, Yanping He, Deqi Li, Wenlong Sun, Xinhua Song
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake
    Miaoqing Hu, Fan Yang, Yawen Huang, Xin You, Desheng Liu, Shan Sun, Sen-Fang Sui
    Science Advances.2021;[Epub]     CrossRef
  • Identification and Optimization of a Minor Allele-Specific siRNA to Prevent PNPLA3 I148M-Driven Nonalcoholic Fatty Liver Disease
    Justin K. Murray, Jason Long, Lei Liu, Shivani Singh, Danielle Pruitt, Michael Ollmann, Elissa Swearingen, Miki Hardy, Oliver Homann, Bin Wu, Jerry Ryan Holder, Kelvin Sham, Brad Herberich, Mei-Chu Lo, Hui Dou, Artem Shkumatov, Monica Florio, Ingrid C. Ru
    Nucleic Acid Therapeutics.2021; 31(5): 324.     CrossRef
  • Molecular mechanism of DLBS3733, a bioactive fraction of Lagerstroemia speciosa (L.) Pers., on ameliorating hepatic lipid accumulation in HepG2 cells
    Olivia M. Tandrasasmita, Guntur Berlian, Raymond R. Tjandrawinata
    Biomedicine & Pharmacotherapy.2021; 141: 111937.     CrossRef
  • The Role of Gut Microbiota on Cholesterol Metabolism in Atherosclerosis
    Margaret Vourakis, Gaétan Mayer, Guy Rousseau
    International Journal of Molecular Sciences.2021; 22(15): 8074.     CrossRef
  • Inhibition of Atherosclerosis and Liver Steatosis by Agmatine in Western Diet-Fed apoE-Knockout Mice Is Associated with Decrease in Hepatic De Novo Lipogenesis and Reduction in Plasma Triglyceride/High-Density Lipoprotein Cholesterol Ratio
    Anna Wiśniewska, Aneta Stachowicz, Katarzyna Kuś, Magdalena Ulatowska-Białas, Justyna Totoń-Żurańska, Anna Kiepura, Kamila Stachyra, Maciej Suski, Mariusz Gajda, Jacek Jawień, Rafał Olszanecki
    International Journal of Molecular Sciences.2021; 22(19): 10688.     CrossRef
  • Therapeutic Targeting of Nonalcoholic Fatty Liver Disease by Downregulating SREBP-1C Expression via AMPK-KLF10 Axis
    Yu-Chi Chen, Rong-Jane Chen, Szu-Yuan Peng, Winston C. Y. Yu, Vincent Hung-Shu Chang
    Frontiers in Molecular Biosciences.2021;[Epub]     CrossRef
  • Regulation of Key Genes for Milk Fat Synthesis in Ruminants
    Tong Mu, Honghong Hu, Yanfen Ma, Xiaofang Feng, Juan Zhang, Yaling Gu
    Frontiers in Nutrition.2021;[Epub]     CrossRef
  • Visceral-to-Subcutaneous Abdominal Fat Ratio Is Associated with Nonalcoholic Fatty Liver Disease and Liver Fibrosis
    Chan-Hee Jung, Eun-Jung Rhee, Hyemi Kwon, Yoosoo Chang, Seungho Ryu, Won-Young Lee
    Endocrinology and Metabolism.2020; 35(1): 165.     CrossRef
  • Lipidomic profiling analysis of the phospholipid molecules in SCAP-induced lipid droplet formation in bovine mammary epithelial cells
    Liqiang Han, Kun Pang, Xiu ling Li, Juan J Loor, Guo yu Yang, Tengyun Gao
    Prostaglandins & Other Lipid Mediators.2020; 149: 106420.     CrossRef
  • Sexual Dimorphism of NAFLD in Adults. Focus on Clinical Aspects and Implications for Practice and Translational Research
    Amedeo Lonardo, Ayako Suzuki
    Journal of Clinical Medicine.2020; 9(5): 1278.     CrossRef
  • Smurf1 aggravates non‐alcoholic fatty liver disease by stabilizing SREBP‐1c in an E3 activity‐independent manner
    Xin Zhang, Yutao Zhan, Wenjun Lin, Fei Zhao, Chaojing Guo, Yujiao Chen, Mengge Du, Dongnian Li, Lingqiang Zhang, Wei An, Hong‐Rui Wang, Ping Xie
    The FASEB Journal.2020; 34(6): 7631.     CrossRef
  • Beneficial Effects of SREBP Decoy Oligodeoxynucleotide in an Animal Model of Hyperlipidemia
    Hyun-Jin An, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyemin Gu, Hyun-Ju Kim, Jaechan Leem, Sung Won Youn, Kwan-Kyu Park
    International Journal of Molecular Sciences.2020; 21(2): 552.     CrossRef
  • Lack of Augmenter of Liver Regeneration Disrupts Cholesterol Homeostasis of Liver in Mice by Inhibiting the AMPK Pathway
    Xin Wang, Ling‐yue Dong, Qu‐jing Gai, Wei‐lun Ai, Yuan Wu, Wei‐chun Xiao, Jing Zhang, Wei An
    Hepatology Communications.2020; 4(8): 1149.     CrossRef
  • HESA-A Attenuates Hepatic Steatosis in NAFLD Rat Model Through the Suppression of SREBP-1c and NF-kβ
    M. Efati, M. Khorrami, Z. Jangravi, A. Z. Mahmoudabadi, M. Raeiszadeh, J. R. Sarshoori
    International Journal of Peptide Research and Therapeutics.2020; 26(3): 1283.     CrossRef
  • Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c
    Kairui Tang, Yuanjun Deng, Chuiyang Zheng, Huan Nie, Maoxing Pan, Runsen Chen, Jiqian Xie, Qinhe Yang, Yupei Zhang
    Oxidative Medicine and Cellular Longevity.2020; 2020: 1.     CrossRef
  • (−)-Epicatechin and the comorbidities of obesity
    Eleonora Cremonini, Dario E. Iglesias, Jiye Kang, Giovanni E. Lombardo, Zahra Mostofinejad, Ziwei Wang, Wei Zhu, Patricia I. Oteiza
    Archives of Biochemistry and Biophysics.2020; 690: 108505.     CrossRef
  • microRNAs targeting cellular cholesterol: implications for combating anticancer drug resistance
    Bernice Monchusi, Mandeep Kaur
    Genes & Cancer.2020; 11(1-2): 20.     CrossRef
  • Cellular acidosis triggers human MondoA transcriptional activity by driving mitochondrial ATP production
    Blake R Wilde, Zhizhou Ye, Tian-Yeh Lim, Donald E Ayer
    eLife.2019;[Epub]     CrossRef
  • Differential Recovery Speed of Activity and Metabolic Rhythms in Rats After an Experimental Protocol of Shift-Work
    Nadia Saderi, Adrián Báez-Ruiz, Lucia E. Azuara-Álvarez, Carolina Escobar, Roberto C. Salgado-Delgado
    Journal of Biological Rhythms.2019; 34(2): 154.     CrossRef
  • Genetically modified mouse models to study hepatic neutral lipid mobilization
    Guenter Haemmerle, Achim Lass
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2019; 1865(5): 879.     CrossRef
  • Preventive effect of trans-chalcone on non-alcoholic steatohepatitis: Improvement of hepatic lipid metabolism
    Elham Karimi-Sales, Abbas Ebrahimi-Kalan, Mohammad Reza Alipour
    Biomedicine & Pharmacotherapy.2019; 109: 1306.     CrossRef
  • A new pathway to eSCAPe lipotoxicity
    Fadila Benhamed, Catherine Postic
    Clinics and Research in Hepatology and Gastroenterology.2018; 42(1): 3.     CrossRef
  • Overexpression of SREBF chaperone (SCAP) enhances nuclear SREBP1 translocation to upregulate fatty acid synthase (FASN) gene expression in bovine mammary epithelial cells
    L.Q. Han, T.Y. Gao, G.Y. Yang, J.J. Loor
    Journal of Dairy Science.2018; 101(7): 6523.     CrossRef
  • Statin use and the risk of hepatocellular carcinoma in patients at high risk: A nationwide nested case-control study
    Gyuri Kim, Suk-Yong Jang, Chung Mo Nam, Eun Seok Kang
    Journal of Hepatology.2018; 68(3): 476.     CrossRef
  • Changes of the Fatty Acid Profile in Erythrocyte Membranes of Patients following 6-Month Dietary Intervention Aimed at the Regression of Nonalcoholic Fatty Liver Disease (NAFLD)
    Dominika Maciejewska, Wojciech Marlicz, Karina Ryterska, Marcin Banaszczak, Dominika Jamioł-Milc, Ewa Stachowska
    Canadian Journal of Gastroenterology and Hepatology.2018; 2018: 1.     CrossRef
  • Systems Analysis of the Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer (2-Ethylhexyl) Phthalate (DEHP)
    Matthew Huff, Willian A. da Silveira, Oliana Carnevali, Ludivine Renaud, Gary Hardiman
    Scientific Reports.2018;[Epub]     CrossRef
  • Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division
    Andreas Bickert, Paul Kern, Martina van Uelft, Stefanie Herresthal, Thomas Ulas, Katharina Gutbrod, Bernadette Breiden, Joachim Degen, Konrad Sandhoff, Joachim L. Schultze, Peter Dörmann, Dieter Hartmann, Reinhard Bauer, Klaus Willecke
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2018; 1863(7): 734.     CrossRef
  • Paradoxical Protective Effect of Perfluorooctanesulfonic Acid Against High-Fat Diet–Induced Hepatic Steatosis in Mice
    Ian Huck, Kevin Beggs, Udayan Apte
    International Journal of Toxicology.2018; 37(5): 383.     CrossRef
  • Developmental and extrahepatic physiological functions of SREBP pathway genes in mice
    Luke J. Engelking, Mary Jo Cantoria, Yanchao Xu, Guosheng Liang
    Seminars in Cell & Developmental Biology.2018; 81: 98.     CrossRef
  • Herbacetin, a flaxseed flavonoid, ameliorates high percent dietary fat induced insulin resistance and lipid accumulation through the regulation of hepatic lipid metabolizing and lipid-regulating enzymes
    Chinnadurai Veeramani, Mohammed A. Alsaif, Khalid S. Al-Numair
    Chemico-Biological Interactions.2018; 288: 49.     CrossRef
  • Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals
    Giuseppe Della Pepa, Claudia Vetrani, Gianluca Lombardi, Lutgarda Bozzetto, Giovanni Annuzzi, Angela Rivellese
    Nutrients.2017; 9(10): 1065.     CrossRef
  • MDG-1, a Potential Regulator of PPARα and PPARγ, Ameliorates Dyslipidemia in Mice
    Xu Wang, Linlin Shi, Sun Joyce, Yuan Wang, Yi Feng
    International Journal of Molecular Sciences.2017; 18(9): 1930.     CrossRef
Close layer
Thyroid
Prevalence and Risk Factors of Subclinical Thyroid Disease
Ye An Kim, Young Joo Park
Endocrinol Metab. 2014;29(1):20-29.   Published online March 14, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.1.20
  • 6,412 View
  • 78 Download
  • 68 Web of Science
  • 70 Crossref
AbstractAbstract PDFPubReader   

Subclinical thyroid disease is defined biochemically by an abnormal thyrotropin (TSH) level and normal serum-free thyroxine level. The prevalence of this condition varies according to the reference range for TSH and geographic or demographic factors. Recently, several studies, including our community-based cohort studies, have reported on the incidence of subclinical thyroid disease in Korea. Using these studies, we reviewed the prevalence and risk factors of subclinical thyroid disease, focusing on subclinical hypothyroidism.

Citations

Citations to this article as recorded by  
  • Appropriateness of Levothyroxine Prescription: A Multicenter Retrospective Study
    Ivan Nicolas Ayala, Cristian Soto Jacome, David Toro-Tobon, Elizabeth Golembiewski, Andrea Garcia-Bautista, Jessica Hidalgo, Sandra Cordova-Madera, Raghda Al Anbari, Jessica Sohn R, Naykky Singh Ospina, Spyridoula Maraka, Marina Joseph, Juan P Brito
    The Journal of Clinical Endocrinology & Metabolism.2024; 109(2): e765.     CrossRef
  • Changes in thyroid function and evolution of subclinical thyroid disease in older men
    Stephanie Y. Tan, S. A. Paul Chubb, Leon Flicker, Osvaldo P. Almeida, Jonathan Golledge, Graeme J. Hankey, Bu B. Yeap
    Clinical Endocrinology.2024; 100(2): 170.     CrossRef
  • Subclinical thyroid dysfunction and the risk of incident atrial fibrillation: A systematic review and meta-analysis
    Hasveer Singh, Mariam Z. Shahid, Stephanie L. Harrison, Deirdre A. Lane, Gregory Y. H. Lip, Sunil Jit R. J. Logantha, Gaetano Santulli
    PLOS ONE.2024; 19(1): e0296413.     CrossRef
  • Subclinical Hypothyroidism and Clinical Outcomes After Percutaneous Coronary Intervention: A Meta-Analysis
    Song Peng Ang, Jia Ee Chia, Vikash Jaiswal, Dhrubajyoti Bandyopadhyay, Jose Iglesias, Gautham Varun Krishna Mohan, Sudarshan Gautam, Thazin Win, Tushar Kumar, Abbas Iqbal, Tong Hong Chia, Wilbert Aronow
    Current Problems in Cardiology.2023; 48(8): 101719.     CrossRef
  • Preliminary observation of thyroid function changes in subclinical thyroid diseases
    Hua-Xin Wang, Wen-Yu Gao, Yang Yang, Yun-Feng Li, Yan Zhang, Xin-Yi Zhang, Yu-Xia Li
    Technology and Health Care.2023; 31(5): 1715.     CrossRef
  • Cardiovascular outcomes in subclinical thyroid disease: an update
    Matthew D. Ettleson
    Current Opinion in Endocrinology, Diabetes & Obesity.2023; 30(5): 218.     CrossRef
  • Effects of whole seaweed consumption on humans: current evidence from randomized-controlled intervention trials, knowledge gaps, and limitations
    João P. Trigo, Marie Palmnäs-Bédard, Mar Vall-Llosera Juanola, Ingrid Undeland
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • The correlation of lipid profile with subclinical and overt hypothyroidism: A cross-sectional study from Syria
    Fatima Tarboush, Mohammad Alsultan, Zaynab Alourfi
    Medicine.2023; 102(37): e34959.     CrossRef
  • Autoimmune thyroid status in subclinical thyroid disorders in patients attending a tertiary care center in Nepal: a hospital-based cross-sectional study
    Vijay Kumar Sharma, Apeksha Niraula, Eans Tara Tuladhar, Aseem Bhattarai, Mithileshwer Raut, Raju Kumar Dubey, Sujata Baidya, Naresh Parajuli
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • The effect of low dose thyroid replacement therapy in patients with episodic migraine and subclinical hypothyroidism: A randomised placebo-controlled trial
    Priya Dev, T.T. Favas, Rishab Jaiswal, Mareena Cyriac, Vijaya Nath Mishra, Abhishek Pathak
    Cephalalgia.2023;[Epub]     CrossRef
  • The Role of Global Longitudinal Strain in Subclinical Hypothyroid Patients With Heart Failure
    Nismat Javed, Vibha Hayagreev, Angel DeLaCruz, Muhammad Saad, Amandeep Singh, Timothy Vittorio
    Cureus.2023;[Epub]     CrossRef
  • Relationship Between Thyroid Hormonal Status in Patients with a Hypothyroid Form of Hashimoto’s Thyroiditis and Iodine Concentrations in Drinking Water
    Olha Kasiyan, Halyna Tkachenko, Natalia Kurhaluk, Svitlana Yurchenko, Alek Manenko
    Biological Trace Element Research.2022; 200(1): 59.     CrossRef
  • Androgen deprivation therapy for prostate cancer and the risk of thyroid diseases
    Jui‐Ming Liu, Yu‐Tang Chen, Chun‐Te Wu, Wen‐Lin Hsu, Ren‐Jun Hsu
    The Prostate.2022; 82(7): 809.     CrossRef
  • Subclinical hypothyroidism in women’s health: from pre- to post-menopause
    Anna Capozzi, Giovanni Scambia, Stefano Lello
    Gynecological Endocrinology.2022; 38(5): 357.     CrossRef
  • Subclinical Hypothyroidism and Cognitive Impairment
    Jung-Min Pyun, Young Ho Park, SangYun Kim
    Journal of Alzheimer's Disease.2022; 88(2): 757.     CrossRef
  • Rosuvastatin potentiates the thyrotropin‐lowering effect of metformin in men with non‐autoimmune subclinical hypothyroidism and prediabetes
    Robert Krysiak, Karolina Kowalcze, Bogusław Okopień
    Journal of Clinical Pharmacy and Therapeutics.2022; 47(12): 2030.     CrossRef
  • Natural history of subclinical hypothyroidism and prognostic factors for the development of overt hypothyroidism: Tehran Thyroid Study (TTS)
    A. Amouzegar, M. Dehghani, H. Abdi, L. Mehran, S. Masoumi, F. Azizi
    Journal of Endocrinological Investigation.2022; 45(12): 2353.     CrossRef
  • Interplay between cardiovascular and thyroid dysfunctions: A review of clinical implications and management strategies
    Sanyal Debmalya, Ray Saumitra, Malhi Harshveer Singh
    Endocrine Regulations.2022; 56(4): 311.     CrossRef
  • Routine Measurement of Thyroid Stimulating Hormone in Patients Presenting With Third-Degree Atrioventricular Block: Do We Really Need It?
    Muhammad Faisal, Zubair Mumtaz, Abdul Mueed, Sajid Ali, Haseeb H Raza, Samra Khan, Sayeda Salma, Mustajab Mujtaba, Musa Karim, Faisal Qadir
    Cureus.2021;[Epub]     CrossRef
  • Update of hypothyroidism and its management in Unani medicine
    Md. Anzar Alam, Mohd Aleemuddin Quamri, Ghulamuddin Sofi, Shabnam Ansari
    Journal of Basic and Clinical Physiology and Pharmacology.2021; 32(2): 1.     CrossRef
  • Endemik guatrın dünü, bugünü ve yarını
    Yılmaz SEZGİN
    Turkish Journal of Family Medicine and Primary Care.2021; 15(1): 1.     CrossRef
  • Prognosis of papillary thyroid carcinoma in relation to preoperative subclinical hypothyroidism
    SY Kang, HR Ahn, HJ Youn, SH Jung
    The Annals of The Royal College of Surgeons of England.2021; 103(5): 367.     CrossRef
  • Stroke in SARS-CoV-2 Infection: A Pictorial Overview of the Pathoetiology
    Saeideh Aghayari Sheikh Neshin, Shima Shahjouei, Eric Koza, Isabel Friedenberg, Faezeh Khodadadi, Mirna Sabra, Firas Kobeissy, Saeed Ansari, Georgios Tsivgoulis, Jiang Li, Vida Abedi, Donna M. Wolk, Ramin Zand
    Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
  • Higher hepatic sterol-binding protein-2 gene expression and serum triglyceride level in methimazole induced subclinical hypothyroid animal model
    Marie Saghaeian Jazi, Mohammad Mostakhdem Hashemi, Abbas Nezhadebrahimi, Azadreza Mansourian
    Comparative Clinical Pathology.2021; 30(4): 627.     CrossRef
  • Subclinical Hypothyroidism: Prevalence, Health Impact, and Treatment Landscape
    Won Sang Yoo, Hyun Kyung Chung
    Endocrinology and Metabolism.2021; 36(3): 500.     CrossRef
  • Thyroid Function and Nutrient Status in the Athlete
    D. Enette Larson-Meyer, Demetre E. Gostas
    Current Sports Medicine Reports.2020; 19(2): 84.     CrossRef
  • Seasonal effects on resting energy expenditure are dependent on age and percent body fat
    Duong Duc Pham, Jeong Hun Lee, Ki Hwan Hong, Youn Joo Jung, Sung Jin Kim, Chae Hun Leem
    Clinical Nutrition.2020; 39(4): 1276.     CrossRef
  • Subclinical hypothyroidism
    Chelsea Simon, Emily Weidman-Evans, Sarah Allen
    JAAPA.2020; 33(5): 21.     CrossRef
  • Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition
    Alice Batistuzzo, Miriam Oliveira Ribeiro
    Archives of Endocrinology and Metabolism.2020; 64(1): 89.     CrossRef
  • Protective effect of a polyherbal bioactive fraction in propylthiouracil-induced thyroid toxicity in ratsby modulation of the hypothalamic–pituitary–thyroid and hypothalamic–pituitary–adrenal axes
    Sneha Singh, Vandana Panda, Sudhamani S., Payal Dande
    Toxicology Reports.2020; 7: 730.     CrossRef
  • Subclinical Hypothyroidism Affects the Long-Term Outcomes of Patients Who Undergo Coronary Artery Bypass Grafting Surgery but Not Heart Valve Surgery
    Hana Kim, Sung Hye Kong, Jae Hoon Moon, Sang Yoon Kim, Kay-Hyun Park, Jun Sung Kim, Joong Haeng Choh, Young Joo Park, Cheong Lim
    Endocrinology and Metabolism.2020; 35(2): 308.     CrossRef
  • Serum FT4 / FT3 Ratio, a Predictive Biochemical Marker for Subclinical Hypothyroidism in Patients with Chronic Kidney Disease
    Venkat Siddarth Chagamreddy, Malligai Elancheran, Murugavel K
    Journal of Evolution of Medical and Dental Sciences.2020; 9(33): 2319.     CrossRef
  • Importance of thyroid-stimulating hormone levels in liver disease
    Hyun Jin Kim
    Journal of Pediatric Endocrinology and Metabolism.2020; 33(9): 1133.     CrossRef
  • Does Hypothyroidism Increase Complications, Lengths of Stay, Readmissions, and Costs Following Primary 1- to 2-Level Lumbar Fusion?
    Rushabh M. Vakharia, Joseph O. Ehiorobo, Bilal Mahmood, Martin W. Roche, Michael A. Mont, Afshin E. Razi
    Clinical Spine Surgery: A Spine Publication.2020; 33(10): E559.     CrossRef
  • Acute psychosis in patients with subclinical hyperthyroidism
    Sohei Kimoto, Kazuhiko Yamamuro, Toshifumi Kishimoto
    Psychiatry and Clinical Neurosciences.2019; 73(6): 348.     CrossRef
  • Screening for thyroid dysfunction and treatment of screen-detected thyroid dysfunction in asymptomatic, community-dwelling adults: a systematic review
    Francesca Reyes Domingo, Marc T. Avey, Marion Doull
    Systematic Reviews.2019;[Epub]     CrossRef
  • Association between subclinical hypothyroidism and metabolic disorders: A retrospective chart review study in an emerging university hospital
    Khaled Aldossari, Sameer Al‐Ghamdi, Jamaan Al‐Zahrani, Anwar Al Jammah, Bader Alanazi, Abdulilah Al‐Briek, Mohammad Alanazi
    Journal of Clinical Laboratory Analysis.2019;[Epub]     CrossRef
  • Investigation of Vitamin D Levels and Metabolic Parameters in Patients With Subclinical Hyperthyroidism
    Müge Keskin, Esra Ademoğlu, Arzu Or Koca, Derun Taner Ertugrul
    Ankara Medical Journal.2019;[Epub]     CrossRef
  • Reference Range and Sociodemographic Characteristics of TSH among Reproductive Age Women in Rural China
    Qiang Su, Shikun Zhang, Mei Hu, Qiaomei Wang, Na Liu, Haiping Shen, Yiping Zhang, Man Zhang
    Biological Trace Element Research.2019; 189(2): 336.     CrossRef
  • Subklinik Hipotiroiditli Çocuklarda Ağız Sağlığı Durumunun Değerlendirilmesi
    Nuray TÜLOĞLU, Tuğçe KALİÇOĞLU, Birgül KIREL
    Journal of Biotechnology and Strategic Health Research.2019; 3(3): 237.     CrossRef
  • Association High-Iodine-Containing Seaweed Soup Consumption after Birth and Subclinical Hypothyroidism in Korean Women: Korea National Health and Nutrition Examination Survey IV (2013–2015)
    Hyunsam Kim, Ha Ni Lee, Jeonghoon Ha
    International Journal of Thyroidology.2019; 12(2): 105.     CrossRef
  • Graves Disease in Central Ghana: Clinical Characteristics and Associated Factors
    Osei Sarfo-Kantanka, Fred Stephen Sarfo, Eunice Oparebea Ansah, Ishmael Kyei
    Clinical Medicine Insights: Endocrinology and Diabetes.2018; 11: 117955141875907.     CrossRef
  • Sex differences in risk factors for subclinical hypothyroidism
    Jeonghoon Ha, Jeongmin Lee, Kwanhoon Jo, Dong-Jun Lim, Moo Il Kang, Bong Yun Cha, Min-Hee Kim
    Endocrine Connections.2018; 7(4): 511.     CrossRef
  • Age-sex disparities and sub-clinical hypothyroidism among patients in Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia
    Habtamu Azene Tekle, Tesfahun Molla Bobe, Efrata Girma Tufa, Fithamlak Bisetegen Solomon
    Journal of Health, Population and Nutrition.2018;[Epub]     CrossRef
  • Subclinical Hypothyroidism and the Risk of Cardiovascular Disease and All-Cause Mortality: A Meta-Analysis of Prospective Cohort Studies
    Shinje Moon, Min Joo Kim, Jae Myung Yu, Hyung Joon Yoo, Young Joo Park
    Thyroid.2018; 28(9): 1101.     CrossRef
  • Age- and gender-specific reference intervals of TSH and free T4 in an iodine-replete area: Data from Korean National Health and Nutrition Examination Survey IV (2013–2015)
    So Young Park, Hae In Kim, Hyun-Kyung Oh, Tae Hyuk Kim, Hye Won Jang, Jae Hoon Chung, Myung-Hee Shin, Sun Wook Kim, Sun Y Lee
    PLOS ONE.2018; 13(2): e0190738.     CrossRef
  • Helicobacter pylori-induced autoimmune thyroiditis: is the pathogenic link concluded or still a hypothesis?
    Santhanamari Thiyagarajan, Anil M.R. Saini, Jamal Alruwaili
    Reviews in Medical Microbiology.2018; 29(2): 64.     CrossRef
  • Evaluation of Thyroid Hormone Levels and Urinary Iodine Concentrations in Koreans Based on the Data from Korea National Health and Nutrition Examination Survey VI (2013 to 2015)
    Jae Hoon Chung
    Endocrinology and Metabolism.2018; 33(2): 160.     CrossRef
  • Transcriptome Network Analysis Reveals Aging-Related Mitochondrial and Proteasomal Dysfunction and Immune Activation in Human Thyroid
    Byuri Angela Cho, Seong-Keun Yoo, Young Shin Song, Su-jin Kim, Kyu Eun Lee, Minho Shong, Young Joo Park, Jeong-Sun Seo
    Thyroid.2018; 28(5): 656.     CrossRef
  • Relation of Subclinical Hypothyroidism is Associated With Cardiovascular Events and All-Cause Mortality in Adults With High Cardiovascular Risk
    Shinje Moon, Sung Hye Kong, Hoon Sung Choi, Yul Hwangbo, Moon-Kyu Lee, Jae Hoon Moon, Hak Chul Jang, Nam Han Cho, Young Joo Park
    The American Journal of Cardiology.2018; 122(4): 571.     CrossRef
  • Subclinical Hypothyroidism and Coronary Revascularization After Coronary Artery Bypass Grafting
    Sung Hye Kong, Ji Won Yoon, Sang Yoon Kim, Tae Jung Oh, Kay-Hyun Park, Joong Haeng Choh, Young Joo Park, Cheong Lim
    The American Journal of Cardiology.2018; 122(11): 1862.     CrossRef
  • A Case of Subclinical Hyperthyroidism Treatment with Herbal Medicine
    Dong-eun Jin, Seok-woo Kim, Hyeon-cheo Shin
    The Journal of Internal Korean Medicine.2018; 39(4): 831.     CrossRef
  • Cardiovascular Risk in Subclinical Hypothyroidism
    Mariana Dobrescu, Diana Păun, Daniel Grigorie, Cătălina Poiană
    Internal Medicine.2018; 15(3): 51.     CrossRef
  • Association between thyroid autoimmunity and Helicobacter pylori infection
    Yun Mi Choi, Tae Yong Kim, Eui Young Kim, Eun Kyung Jang, Min Ji Jeon, Won Gu Kim, Young Kee Shong, Won Bae Kim
    The Korean Journal of Internal Medicine.2017; 32(2): 309.     CrossRef
  • Effect of Marijuana Use on Thyroid Function and Autoimmunity
    Sonali Malhotra, Rubina A. Heptulla, Peter Homel, Roja Motaghedi
    Thyroid.2017; 27(2): 167.     CrossRef
  • Insidious danger in childhood era's: subclinical hypothyroidism
    Ayşegül Alpcan, Ayça Törel Ergür, Serkan Tursun
    Ortadoğu Tıp Dergisi.2017; 9(1): 34.     CrossRef
  • Thyroid Stimulating Hormone Reference Range and Prevalence of Thyroid Dysfunction in the Korean Population: Korea National Health and Nutrition Examination Survey 2013 to 2015
    Won Gu Kim, Won Bae Kim, Gyeongji Woo, Hyejin Kim, Yumi Cho, Tae Yong Kim, Sun Wook Kim, Myung-Hee Shin, Jin Woo Park, Hai-Lin Park, Kyungwon Oh, Jae Hoon Chung
    Endocrinology and Metabolism.2017; 32(1): 106.     CrossRef
  • Thyroid diseases and risk of non-thyroidal pathology
    R I Glushakov, E V Kozyrko, I V Sobolev, S A Ermolova, O V Vlaseva, A A Kuzin, N I Tapilskaya
    Kazan medical journal.2017; 98(1): 77.     CrossRef
  • Hipertiroidismo
    M. Toni, J. Pineda, E. Anda, J.C. Galofré
    Medicine - Programa de Formación Médica Continuada Acreditado.2016; 12(13): 731.     CrossRef
  • Subclinical Hypothyroidism in Childhood Cancer Survivors
    Hyun Joo Lee, Seung Min Hahn, Song Lee Jin, Yoon Jung Shin, Sun Hee Kim, Yoon Sun Lee, Hyo Sun Kim, Chuhl Joo Lyu, Jung Woo Han
    Yonsei Medical Journal.2016; 57(4): 915.     CrossRef
  • Comparison of universal screening with targeted high-risk case finding for diagnosis of thyroid disorders
    Sima Nazarpour, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Maryam Tohidi, Hamid AlaviMajd, Fereidoun Azizi
    European Journal of Endocrinology.2016; 174(1): 77.     CrossRef
  • Association of low baseline free thyroxin levels with progression of coronary artery calcification over 4 years in euthyroid subjects: the Kangbuk Samsung Health Study
    Hye‐Jeong Park, Jihyun Kim, Eun Jin Han, Se Eun Park, Cheol‐Young Park, Won‐Young Lee, Ki‐Won Oh, Sung‐Woo Park, Eun‐Jung Rhee
    Clinical Endocrinology.2016; 84(6): 889.     CrossRef
  • Distinct Features of Nonthyroidal Illness in Critically Ill Patients With Infectious Diseases
    Woo Kyung Lee, Sena Hwang, Daham Kim, Seul Gi Lee, Seonhyang Jeong, Mi-Youn Seol, Hyunji Kim, Cheol Ryong Ku, Dong Yeop Shin, Woong Youn Chung, Eun Jig Lee, Jandee Lee, Young Suk Jo
    Medicine.2016; 95(14): e3346.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
  • Reference interval for thyrotropin in a ultrasonography screened Korean population
    Mijin Kim, Tae Yong Kim, Soo Han Kim, Yunkyoung Lee, Su-yeon Park, Hyung-don Kim, Hyemi Kwon, Yun Mi Choi, Eun Kyung Jang, Min Ji Jeon, Won Gu Kim, Young Kee Shong, Won Bae Kim
    The Korean Journal of Internal Medicine.2015; 30(3): 335.     CrossRef
  • Incidence and Prevalence of Overt Hypothyroidism and Causative Diseases in Korea as Determined Using Claims Data Provided by the Health Insurance Review and Assessment Service
    Gi Hyeon Seo, Jae Hoon Chung
    Endocrinology and Metabolism.2015; 30(3): 288.     CrossRef
  • Subclinical Hypothyroidism and Cardiovascular Disease
    Sunghwan Suh, Duk Kyu Kim
    Endocrinology and Metabolism.2015; 30(3): 246.     CrossRef
  • Bone Health and Clinical Results after Hip Fracture Surgery in Patients with Subclinical Hypothyroidism
    Ki-Choul Kim, Young-Kyun Lee, You Jin Lee, Yong-Chan Ha, Kyung-Hoi Koo
    Journal of Bone Metabolism.2014; 21(3): 213.     CrossRef
  • Subclinical Thyroid Dysfunction in the Elderly
    Ki Dong Ko
    Journal of the Korean Geriatrics Society.2014; 18(3): 111.     CrossRef
  • Subclinical hypothyroidism in addition to common risk scores for prediction of cardiovascular disease: a 10-year community-based cohort study
    Tae Hyuk Kim, Hoon Sung Choi, Ji Cheol Bae, Jae Hoon Moon, Hyung-Kwan Kim, Sung Hee Choi, Soo Lim, Do Joon Park, Kyong Soo Park, Hak Chul Jang, Moon-Kyu Lee, Nam H Cho, Young Joo Park
    European Journal of Endocrinology.2014; 171(5): 649.     CrossRef
Close layer
Obesity and Metabolism
Optimal Waist Circumference Cutoff Values for the Diagnosis of Abdominal Obesity in Korean Adults
Yeong Sook Yoon, Sang Woo Oh
Endocrinol Metab. 2014;29(4):418-426.   Published online December 29, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.4.418
  • 5,528 View
  • 69 Download
  • 64 Web of Science
  • 70 Crossref
AbstractAbstract PDFPubReader   

Abdominal obesity is associated closely with insulin resistance, diabetes, and cardiovascular disease. Waist circumference (WC) is a useful surrogate marker commonly used for abdominal adiposity. The determination of WC cutoff levels is important in the prevention and treatment of obesity, type 2 diabetes, and related cardiovascular diseases. Recent epidemiological evidence suggested that appropriate optimal cutoffs for Koreans ranged over 80 to 89.8 cm in males and 76.1 to 86.5 cm in females. We analyzed the data from two large cohorts using receiver operating characteristic curve analysis with the incidences of diabetes, hypertension, dyslipidemia, cerebrovascular disease, myocardial infarct, angina, coronary artery disease, and multiple metabolic risk factors as outcome variables. Optimal WC cutoff points for Koreans were 85 cm in males and 80 cm in females. However, considering the prevalence of abdominal obesity and the health costs for its prevention and management, 90 cm in males and 85 cm in females are probably more appropriate thresholds for abdominal obesity. These values may be modified once better research is performed through prospective studies using representative populations, common health outcomes, and proper analytical approaches.

Citations

Citations to this article as recorded by  
  • The prevalence and factors associated with sarcopenia in Thai older adults: A systematic review and meta-analysis
    Phatcharaphon Whaikid, Noppawan Piaseu
    International Journal of Nursing Sciences.2024; 11(1): 31.     CrossRef
  • Machine learning analysis for the association between breast feeding and metabolic syndrome in women
    Jue Seong Lee, Eun-Saem Choi, Hwasun Lee, Serhim Son, Kwang-Sig Lee, Ki Hoon Ahn
    Scientific Reports.2024;[Epub]     CrossRef
  • Association between waist circumference change after smoking cessation and incidence of hypertension in Korean adults
    H.J. Lee, J.W. Choi
    Public Health.2024; 229: 73.     CrossRef
  • Waist circumference and end‐stage renal disease based on glycaemic status: National Health Insurance Service data 2009–2018
    Yun Kyung Cho, Ji Hye Huh, Shinje Moon, Yoon Jung Kim, Yang‐Hyun Kim, Kyung‐do Han, Jun Goo Kang, Seong Jin Lee, Sung‐Hee Ihm
    Journal of Cachexia, Sarcopenia and Muscle.2023; 14(1): 585.     CrossRef
  • Simple anthropometric measures to predict visceral adipose tissue area in middle-aged Indonesian men
    Sahat Basana Romanti Ezer Matondang, Bennadi Adiandrian, Komang Shary Karismaputri, Cicilia Marcella, Joedo Prihartono, Dicky Levenus Tahapary, Yosuke Yamada
    PLOS ONE.2023; 18(1): e0280033.     CrossRef
  • Sleep Quality in Women with Premenstrual Syndrome Is Associated with Metabolic Syndrome-Related Variables
    Hyejin Chun, Miae Doo
    Healthcare.2023; 11(10): 1492.     CrossRef
  • Gender, Age and Clinical Characteristics of Older Adults with High-Risk of Obstructive Sleep Apnea Assessed by the STOP-Bang Questionnaire
    Gyu Lee Kim, Yun Jin Kim, Jeong Gyu Lee, Yu Hyeon Yi, Young Jin Tak, Seung Hun Lee, Young Jin Ra, Sang Yeoup Lee, Young Hye Cho, Eun Ju Park, Youngin Lee, Jung In Choi, Sae Rom Lee, Ryuk Jun Kwon, Soo Min Son
    Korean Journal of Clinical Geriatrics.2023; 24(2): 72.     CrossRef
  • Body Composition and Cardiovascular Risk: A Study of Polish Military Flying Personnel
    Agata Gaździńska, Stefan Gaździński, Paweł Jagielski, Paweł Kler
    Metabolites.2023; 13(10): 1102.     CrossRef
  • Associated Factors with Changes of Metabolic Abnormalities among General Population in COVID-19 Pandemic
    Eunjoo Kwon, Eun-Hee Nah, Suyoung Kim, Seon Cho, Hyeran Park
    Korean Journal of Health Promotion.2023; 23(2): 55.     CrossRef
  • Effects of Pharmacoacupuncture for Obesity: A Systematic Review and Meta-Analysis
    Seyun Kim, Mi-Yeon Song, Won-Seok Chung, Hyungsuk Kim, Woo-Chul Shin, Junhyuk Kang, Joonwon Seo, Sangwoo Seo, Seung Ho Yu, Jung-Hyun Lim, Su-Hwan Ji, Jae-Heung Cho
    Journal of Korean Medicine for Obesity Research.2023; 23(2): 112.     CrossRef
  • Associations Between Elevated Growth Differentiation Factor-15 and Sarcopenia Among Community-dwelling Older Adults
    Miji Kim, Jeremy D Walston, Chang Won Won, Anne B Newman
    The Journals of Gerontology: Series A.2022; 77(4): 770.     CrossRef
  • The association of obesity with thyroid carcinoma risk
    Xiao‐Ni Ma, Cheng‐Xu Ma, Li‐Jie Hou, Song‐Bo Fu
    Cancer Medicine.2022; 11(4): 1136.     CrossRef
  • A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women
    Myung Ji Nam, Hyunjin Kim, Yeon Joo Choi, Kyung-Hwan Cho, Seon Mee Kim, Yong-Kyun Roh, Kyungdo Han, Jin-Hyung Jung, Yong-Gyu Park, Joo-Hyun Park, Do-Hoon Kim
    Journal of Clinical Medicine.2022; 11(10): 2795.     CrossRef
  • Association of Metabolic Health and Central Obesity with the Risk of Thyroid Cancer: Data from the Korean Genome and Epidemiology Study
    Dung N. Nguyen, Jin Hee Kim, Mi Kyung Kim
    Cancer Epidemiology, Biomarkers & Prevention.2022; 31(3): 543.     CrossRef
  • Interaction of polygenic variants specific for abdominal obesity risk with energy metabolism in large Korean cohorts
    Sunmin Park
    Nutrition Bulletin.2022; 47(3): 307.     CrossRef
  • Effects of Oral Health Behavior and Mental Health on Metabolic Syndrome in Korean Adults
    Jin-Ah Jung, Hye-Won Cheon, Sang-Eun Moon, Sun-Hwa Hong
    Journal of Dental Hygiene Science.2022; 22(2): 90.     CrossRef
  • Relation of Dietary n-3 and n-6 Fatty Acid Intakes to Metabolic Syndrome in Middle-Aged People Depending on the Level of HbA1c: A Review of National Health and Nutrition Survey Data from 2014 to 2016
    Seo-Woo Park, Do-Yeong Kim, Gyeong-Tae Bak, Dae-Sung Hyun, Sung-Kyung Kim
    Medicina.2022; 58(8): 1017.     CrossRef
  • Synergistic Interaction between Hyperuricemia and Abdominal Obesity as a Risk Factor for Metabolic Syndrome Components in Korean Population
    Min Jin Lee, Ah Reum Khang, Yang Ho Kang, Mi Sook Yun, Dongwon Yi
    Diabetes & Metabolism Journal.2022; 46(5): 756.     CrossRef
  • Risk of Carotid Atherosclerosis in Subjects with Prediabetes Overlapping Metabolic Syndrome
    Seol A Jang, Kyoung Min Kim, Seok Won Park, Chul Sik Kim
    Metabolic Syndrome and Related Disorders.2022; 20(10): 599.     CrossRef
  • Association of high body mass index, waist circumference, and body fat percentage with sarcopenia in older women
    Myung Chul Yoo, Chang Won Won, Yunsoo Soh
    BMC Geriatrics.2022;[Epub]     CrossRef
  • Relationship between low skeletal muscle mass, sarcopenic obesity and left ventricular diastolic dysfunction in Korean adults
    Jee Hee Yoo, Sung Woon Park, Ji Eun Jun, Sang‐Man Jin, Kyu Yeon Hur, Moon‐Kyu Lee, Mira Kang, Gyuri Kim, Jae Hyeon Kim
    Diabetes/Metabolism Research and Reviews.2021;[Epub]     CrossRef
  • Association of Early-Life Mental Health With Biomarkers in Midlife and Premature Mortality
    George B. Ploubidis, G. David Batty, Praveetha Patalay, David Bann, Alissa Goodman
    JAMA Psychiatry.2021; 78(1): 38.     CrossRef
  • A clinical evaluation of noninvasive and contactless radiofrequency technique in the treatment of abdominal fat
    Jie Qin, Meng‐er Guo, Xue‐gang Xu, Chao Zhang, Cheng‐qian Yu, Yuan‐hong Li, Hong‐duo Chen
    Journal of Cosmetic Dermatology.2021; 20(9): 2765.     CrossRef
  • Exercise training and burdock root (Arctium lappa L.) extract independently improve abdominal obesity and sex hormones in elderly women with metabolic syndrome
    Min-Seong Ha, Jang Soo Yook, Minchul Lee, Kazuya Suwabe, Woo-Min Jeong, Jae-Jun Kwak, Hideaki Soya
    Scientific Reports.2021;[Epub]     CrossRef
  • Effect of body mass index and abdominal obesity on mortality after percutaneous coronary intervention: a nationwide, population-based study
    Woo-Hyuk Song, Eun Hui Bae, Jeong Cheon Ahn, Tae Ryom Oh, Yong-Hyun Kim, Jin Seok Kim, Sun-Won Kim, Soo Wan Kim, Kyung-Do Han, Sang-Yup Lim
    The Korean Journal of Internal Medicine.2021; 36(Suppl 1): S90.     CrossRef
  • Individual and Synergistic Relationships of Low Muscle Mass and Low Muscle Function with Depressive Symptoms in Korean Older Adults
    Youngyun Jin, Seamon Kang, Hyunsik Kang
    International Journal of Environmental Research and Public Health.2021; 18(19): 10129.     CrossRef
  • Association between Metabolic Syndrome and the Number of Remaining Teeth in Postmenopausal Women: A Cross-Sectional Analysis Using the Korean National Health and Nutritional Examination Survey
    Jeong-In Kim, Choong-Ho Choi, Ki-Ho Chung
    Journal of Clinical Medicine.2021; 10(20): 4759.     CrossRef
  • No Association between Metabolic Syndrome and Periodontitis in Korean Postmenopausal Women
    Jeong-In Kim, Choong-Ho Choi, Ki-Ho Chung
    International Journal of Environmental Research and Public Health.2021; 18(21): 11110.     CrossRef
  • Relative Lean Body Mass and Waist Circumference for the Identification of Metabolic Syndrome in the Korean General Population
    Eunjoo Kwon, Eun-Hee Nah, Suyoung Kim, Seon Cho
    International Journal of Environmental Research and Public Health.2021; 18(24): 13186.     CrossRef
  • SVM-based waist circumference estimation using Kinect
    Dasom Seo, Euncheol Kang, Yu-mi Kim, Sun-Young Kim, Il-Seok Oh, Min-Gul Kim
    Computer Methods and Programs in Biomedicine.2020; 191: 105418.     CrossRef
  • Effects of abdominal obesity on the association between air pollution and kidney function
    Su-Min Jeong, Jin-Ho Park, Hyun-Jin Kim, Hyuktae Kwon, Seo Eun Hwang
    International Journal of Obesity.2020; 44(7): 1568.     CrossRef
  • Effect of sarcopenic obesity on deterioration of physical function in the elderly
    Hyun Ho Kong, Chang Won Won, Won Kim
    Archives of Gerontology and Geriatrics.2020; 89: 104065.     CrossRef
  • Effects of low skeletal muscle mass and sarcopenic obesity on albuminuria: a 7-year longitudinal study
    Jee Hee Yoo, Gyuri Kim, Sung Woon Park, Min Sun Choi, Jiyeon Ahn, Sang-Man Jin, Kyu Yeon Hur, Moon-Kyu Lee, Mira Kang, Jae Hyeon Kim
    Scientific Reports.2020;[Epub]     CrossRef
  • A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents


    Yongting Yuan, Hong Xie, Lili Sun, Bangxuan Wang, Li Zhang, Hui Han, Rongying Yao, Yehuan Sun, Lianguo Fu
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 1653.     CrossRef
  • The Association between the Ratio of Energy Intake to Basal Metabolic Rate and Physical Activity to Sarcopenia: Using the Korea National Health and Nutrition Examination Surveys (2008–2011)
    Yu Jin Cho, Mi Hee Cho, Bomi Han, Minji Park, Seolah Bak, Minseon Park
    Korean Journal of Family Medicine.2020; 41(3): 167.     CrossRef
  • Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity
    Robert Ross, Ian J. Neeland, Shizuya Yamashita, Iris Shai, Jaap Seidell, Paolo Magni, Raul D. Santos, Benoit Arsenault, Ada Cuevas, Frank B. Hu, Bruce A. Griffin, Alberto Zambon, Philip Barter, Jean-Charles Fruchart, Robert H. Eckel, Yuji Matsuzawa, Jean-
    Nature Reviews Endocrinology.2020; 16(3): 177.     CrossRef
  • Lung function as a predictor of incident type 2 diabetes in community-dwelling adults: A longitudinal finding over 12 years from the Korean Genome and Epidemiology Study
    J.H. Lee, H.S. Lee, Y.J. Lee
    Diabetes & Metabolism.2020; 46(5): 392.     CrossRef
  • Sex- and age-specific effects of energy intake and physical activity on sarcopenia
    Yu Jin Cho, Youn-Hee Lim, Jae Moon Yun, Hyung-Jin Yoon, Minseon Park
    Scientific Reports.2020;[Epub]     CrossRef
  • Protective effect of smoking cessation on subsequent myocardial infarction and ischemic stroke independent of weight gain: A nationwide cohort study
    Jung-Hwan Cho, Hye-Mi Kwon, Se-Eun Park, Jin-Hyung Jung, Kyung-Do Han, Yong-Gyu Park, Yang-Hyun Kim, Eun-Jung Rhee, Won-Young Lee, Michael Cummings
    PLOS ONE.2020; 15(7): e0235276.     CrossRef
  • Optimal Cutoff Values for Anthropometric Adiposity Measures of Sri Lankan Adult Women
    Nirmala Rathnayake, Gayani Alwis, Janaka Lenora, Sarath Lekamwasam
    Journal of Obesity.2020; 2020: 1.     CrossRef
  • Differences in the Association Among the Vitamin D Concentration, Dietary Macronutrient Consumption, and Metabolic Syndrome Depending on Pre- and Postmenopausal Status in Korean Women: A Cross-Sectional Study


    Hyejin Chun, Gi Dae Kim, Miae Doo
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 3601.     CrossRef
  • Patterns of change in cardiovascular risks of Korean male workers: a 10-year cohort analysis using the National Health Insurance Service–National Sample Cohort (NHIS-NSC) 2.0 database
    Hosihn Ryu, Jiyeon Jung, Jihyun Moon
    BMJ Open.2020; 10(11): e038446.     CrossRef
  • Predictive Performance of Glycated Hemoglobin for Incident Diabetes Compared with Glucose Tolerance Test According to Central Obesity
    Suji Yoo, Jaehoon Jung, Hosu Kim, Kyoung Young Kim, Soo Kyoung Kim, Jungwha Jung, Jong Ryeal Hahm, Jong Ha Baek
    Endocrinology and Metabolism.2020; 35(4): 873.     CrossRef
  • Metabolic Syndrome and Risk of Lung Cancer: An Analysis of Korean National Health Insurance Corporation Database
    Sooim Sin, Chang-Hoon Lee, Sun Mi Choi, Kyung-Do Han, Jinwoo Lee
    The Journal of Clinical Endocrinology & Metabolism.2020; 105(11): e4102.     CrossRef
  • Association of body mass index with bladder cancer risk in men depends on abdominal obesity
    Jin Bong Choi, Jung Ho Kim, Sung-Hoo Hong, Kyung-Do Han, U-Syn Ha
    World Journal of Urology.2019; 37(11): 2393.     CrossRef
  • Lower Leg Fat Depots Are Associated with Albuminuria Independently of Obesity, Insulin Resistance, and Metabolic Syndrome (Korea National Health and Nutrition Examination Surveys 2008 to 2011)
    Eugene Han, Nan Hee Cho, Mi Kyung Kim, Hye Soon Kim
    Diabetes & Metabolism Journal.2019; 43(4): 461.     CrossRef
  • The Risk of Myocardial Infarction and Ischemic Stroke According to Waist Circumference in 21,749,261 Korean Adults: A Nationwide Population-Based Study
    Jung-Hwan Cho, Eun-Jung Rhee, Se-Eun Park, Hyemi Kwon, Jin-Hyung Jung, Kyung-Do Han, Yong-Gyu Park, Hye Soon Park, Yang-Hyun Kim, Soon-Jib Yoo, Won-Young Lee
    Diabetes & Metabolism Journal.2019; 43(2): 206.     CrossRef
  • Association between Serum Gamma-Glutamyltransferase and Prevalence of Metabolic Syndrome Using Data from the Korean Genome and Epidemiology Study
    Mi Young Lee, Dae Sung Hyon, Ji Hye Huh, Hae Kyung Kim, Sul Ki Han, Jang Young Kim, Sang Baek Koh
    Endocrinology and Metabolism.2019; 34(4): 390.     CrossRef
  • The Association between Obesity Phenotypes and Early Renal Function Decline in Adults without Hypertension, Dyslipidemia, and Diabetes
    Jung In Choi, Young Hye Cho, Sang Yeoup Lee, Dong Wook Jeong, Jeong Gyu Lee, Yu Hyeon Yi, Young Jin Tak, Seung Hun Lee, Hye Rim Hwang, Eun Ju Park
    Korean Journal of Family Medicine.2019; 40(3): 176.     CrossRef
  • Sex differences in the association between asthma incidence and modifiable risk factors in Korean middle-aged and older adults: NHIS-HEALS 10-year cohort
    Susan Park, Sun-Young Jung, Jin-Won Kwon
    BMC Pulmonary Medicine.2019;[Epub]     CrossRef
  • Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity
    Seung-Soon Im, Hyeon Young Park, Jong Cheol Shon, In-Sung Chung, Ho Chan Cho, Kwang-Hyeon Liu, Dae-Kyu Song, Kyoung Heon Kim
    PLOS ONE.2019; 14(3): e0213285.     CrossRef
  • Estimating the Cutoff Points of Time-Dependent Risk Factors by Using Joint Modeling of Longitudinal and Time-to-Event Data: A 14-Year Follow-up Study—Tehran Lipid and Glucose Study
    Nezhat Shakeri, Fereidoun Azizi
    Asia Pacific Journal of Public Health.2019; 31(8): 728.     CrossRef
  • Metabolic Obesity Phenotypes and Thyroid Cancer Risk: A Cohort Study
    Hyemi Kwon, Yoosoo Chang, Ara Cho, Jiin Ahn, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Hocheol Shin, Seungho Ryu, Eun-Jung Rhee
    Thyroid.2019; 29(3): 349.     CrossRef
  • Trends and Cut-Point Changes in Obesity Parameters by Age Groups Considering Metabolic Syndrome
    Hyung Jun Park, Young Ho Hong, Yun Jung Cho, Ji Eun Lee, Jae Moon Yun, Hyuktae Kwon, Sang Hyuck Kim
    Journal of Korean Medical Science.2018;[Epub]     CrossRef
  • Difference in prostate cancer incidence around sixty years: effects of age and metabolic diseases
    Jin Bong Choi, Jung Ho Kim, Sung‐Hoo Hong, Kyung‐Do Han, U‐Syn Ha
    Cancer Medicine.2018; 7(6): 2736.     CrossRef
  • The Association of Low Back Pain with Obesity and Abdominal Obesity among Koreans Aged 50 Years or More
    Eun Young Choi
    Korean Journal of Health Promotion.2018; 18(3): 119.     CrossRef
  • Association between oral health and colorectal adenoma in a screening population
    Donghyoun Lee, Kyung Uk Jung, Hyung Ook Kim, Hungdai Kim, Ho-Kyung Chun
    Medicine.2018; 97(37): e12244.     CrossRef
  • An association of metabolic syndrome and chronic kidney disease from a 10-year prospective cohort study
    Ji Hye Huh, Dhananjay Yadav, Jae Seok Kim, Jung-Woo Son, Eunhee Choi, Seong Hwan Kim, Chol Shin, Ki-Chul Sung, Jang Young Kim
    Metabolism.2017; 67: 54.     CrossRef
  • Anatomic fat depots and cardiovascular risk: a focus on the leg fat using nationwide surveys (KNHANES 2008–2011)
    Eugene Han, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, In-Kyu Lee, Bong-Soo Cha
    Cardiovascular Diabetology.2017;[Epub]     CrossRef
  • Association between Body Weight Changes and Menstrual Irregularity: The Korea National Health and Nutrition Examination Survey 2010 to 2012
    Kyung Min Ko, Kyungdo Han, Youn Jee Chung, Kun-Ho Yoon, Yong Gyu Park, Seung-Hwan Lee
    Endocrinology and Metabolism.2017; 32(2): 248.     CrossRef
  • Low muscle mass and risk of type 2 diabetes in middle-aged and older adults: findings from the KoGES
    Jang Won Son, Seong Su Lee, Sung Rae Kim, Soon Jib Yoo, Bong Yun Cha, Ho Young Son, Nam H. Cho
    Diabetologia.2017; 60(5): 865.     CrossRef
  • Safety and efficacy of a non-contact radiofrequency device for body contouring in Asians
    Dong Hye Suh, Chang Min Kim, Sang Jun Lee, Hyunjoo Kim, Suk Keu Yeom, Hwa Jung Ryu
    Journal of Cosmetic and Laser Therapy.2017; 19(2): 89.     CrossRef
  • Arterial stiffness and its association with clustering of metabolic syndrome risk factors
    Wanda R. P. Lopes-Vicente, Sara Rodrigues, Felipe X. Cepeda, Camila Paixão Jordão, Valéria Costa-Hong, Akothirene C. B. Dutra-Marques, Jefferson C. Carvalho, Maria Janieire N. N. Alves, Luiz A. Bortolotto, Ivani C. Trombetta
    Diabetology & Metabolic Syndrome.2017;[Epub]     CrossRef
  • Associations of sitting time and occupation with metabolic syndrome in South Korean adults: a cross-sectional study
    Jin Young Nam, Juyoung Kim, Kyung Hee Cho, Young Choi, Jaewoo Choi, Jaeyong Shin, Eun-Cheol Park
    BMC Public Health.2016;[Epub]     CrossRef
  • Associations of Obesity and Dyslipidemia with Intake of Sodium, Fat, and Sugar among Koreans: a Qualitative Systematic Review
    Yoon Jung Kang, Hye Won Wang, Se Young Cheon, Hwa Jung Lee, Kyung Mi Hwang, Hae Seong Yoon
    Clinical Nutrition Research.2016; 5(4): 290.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
  • Ambient Temperature and Prevalence of Obesity: A Nationwide Population-Based Study in Korea
    Hae Kyung Yang, Kyungdo Han, Jae-Hyoung Cho, Kun-Ho Yoon, Bong-Yun Cha, Seung-Hwan Lee, David Meyre
    PLOS ONE.2015; 10(11): e0141724.     CrossRef
  • Acupoint Catgut Embedding for Obesity: Systematic Review and Meta-Analysis
    Taipin Guo, Yulan Ren, Jun Kou, Jing Shi, Sun Tianxiao, Fanrong Liang
    Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
  • Elderly men over 65 years of age with late-onset hypogonadism benefit as much from testosterone treatment as do younger men
    Farid Saad, Aksam Yassin, Ahmad Haider, Gheorghe Doros, Louis Gooren
    Korean Journal of Urology.2015; 56(4): 310.     CrossRef
  • Administration of Hwang-Ryun-Haedok-tang, a Herbal Complex, for Patients With Abdominal Obesity: A Case Series
    Seungwon Kwon, WooSang Jung, A Ri Byun, SangKwan Moon, KiHo Cho, KyoungHo Shin
    EXPLORE.2015; 11(5): 401.     CrossRef
Close layer
Obesity and Metabolism
Connecting Myokines and Metabolism
Rexford S. Ahima, Hyeong-Kyu Park
Endocrinol Metab. 2015;30(3):235-245.   Published online August 4, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.3.235
  • 7,304 View
  • 127 Download
  • 70 Web of Science
  • 69 Crossref
AbstractAbstract PDFPubReader   

Skeletal muscle is the largest organ of the body in non-obese individuals and is now considered to be an endocrine organ. Hormones (myokines) secreted by skeletal muscle mediate communications between muscle and liver, adipose tissue, brain, and other organs. Myokines affect muscle mass and myofiber switching, and have profound effects on glucose and lipid metabolism and inflammation, thus contributing to energy homeostasis and the pathogenesis of obesity, diabetes, and other diseases. In this review, we summarize recent findings on the biology of myokines and provide an assessment of their potential as therapeutic targets.

Citations

Citations to this article as recorded by  
  • Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases
    Helena Trevisan Schroeder, Carlos Henrique De Lemos Muller, Thiago Gomes Heck, Mauricio Krause, Paulo Ivo Homem de Bittencourt
    Cell Stress and Chaperones.2024; 29(1): 116.     CrossRef
  • Correlations between serum testosterone and irisin levels in a sample of Egyptian men with metabolic syndrome; (case-control study)
    Inass Hassan Ahmad, Eman Roshdy Mohamed Mostafa, Shymaa Abdelhafeez Mohammed, Walaa Shipl, Amany Ahmed Soliman, Marwa Said
    Archives of Physiology and Biochemistry.2023; 129(1): 180.     CrossRef
  • Epidemiological, mechanistic, and practical bases for assessment of cardiorespiratory fitness and muscle status in adults in healthcare settings
    Jaime A. Gallo-Villegas, Juan C. Calderón
    European Journal of Applied Physiology.2023; 123(5): 945.     CrossRef
  • Myokines: Crosstalk and Consequences on Liver Physiopathology
    Aurore Dumond Bourie, Jean-Baptiste Potier, Michel Pinget, Karim Bouzakri
    Nutrients.2023; 15(7): 1729.     CrossRef
  • Pharmacological and physiological roles of adipokines and myokines in metabolic-related dementia
    Archana Arjunan, Juhyun Song
    Biomedicine & Pharmacotherapy.2023; 163: 114847.     CrossRef
  • Muscle quality: the assessment, prognosis, and intervention
    翔 畑中, 洋祐 大須賀
    Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics.2023; 60(2): 103.     CrossRef
  • Exercise Therapy for People With Sarcopenic Obesity: Myokines and Adipokines as Effective Actors
    Hamed Alizadeh Pahlavani
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Histone Deacetylases as Modulators of the Crosstalk Between Skeletal Muscle and Other Organs
    Alessandra Renzini, Marco D’Onghia, Dario Coletti, Viviana Moresi
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Irisin response to acute moderate intensity exercise and high intensity interval training in youth of different obesity statuses: A randomized crossover trial
    Benjamin H. Colpitts, Brittany V. Rioux, Ashley L. Eadie, Keith R. Brunt, Martin Sénéchal
    Physiological Reports.2022;[Epub]     CrossRef
  • The effects of whole‐body vibration amplitude on glucose metabolism, inflammation, and skeletal muscle oxygenation
    Adeola A. Sanni, Anson M. Blanks, Cassandra C. Derella, Chase Horsager, Reva H. Crandall, Jacob Looney, Savanna Sanchez, Kimberly Norland, Bingwei Ye, Jeffrey Thomas, Xiaoling Wang, Ryan A. Harris
    Physiological Reports.2022;[Epub]     CrossRef
  • Preoperative Thoracic Muscle Mass Predicts Bone Density Change After Parathyroidectomy in Primary Hyperparathyroidism
    Seung Won Burm, Namki Hong, Seunghyun Lee, Gi Jeong Kim, Sang Hyun Hwang, Jongju Jeong, Yumie Rhee
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(6): e2474.     CrossRef
  • Single skeletal muscle fiber mechanical properties: a muscle quality biomarker of human aging
    Jae-Young Lim, Walter R. Frontera
    European Journal of Applied Physiology.2022; 122(6): 1383.     CrossRef
  • Hybrid HIIT/isometrics strength training programs: a paradigm shift for physical exercise
    Luis Wyche, Guillermo Rojo-Gil, María Marín-Peiró, José Antonio Pérez-Turpin, Jaime Enrique Gómez-Paternina, Carlos Elvira, Duncan Ayers
    Scientific Journal of Sport and Performance.2022; 1(1): 37.     CrossRef
  • The Effect of Irisin on Proliferation, Apoptosis, and Expression of Metastasis Markers in Prostate Cancer Cell Lines
    Atiye Saeedi Sadr, Hassan Ehteram, Elahe Seyed Hosseini, Marziyeh Alizadeh Zarei, Hassan Hassani Bafrani, Hamed Haddad Kashani
    Oncology and Therapy.2022; 10(2): 377.     CrossRef
  • Molecular mechanisms of adaptive and therapeutic effects of physical activity in patients with cardiovascular diseases
    V.E. Vladimirsky, E.V. Vladimirsky, A.N. Lunina, A.D. Fesyun, A.P. Rachin, O.D. Lebedeva, M.Yu. Yakovlev, M.A. Tubekova
    Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kul'tury.2022; 99(2): 69.     CrossRef
  • Studies in Rats of Combined Muscle and Liver Perfusion and of Muscle Extract Indicate That Contractions Release a Muscle Hormone Directly Enhancing Hepatic Glycogenolysis
    Xiao X. Han, Jens J. Holst, Henrik Galbo
    Journal of Personalized Medicine.2022; 12(5): 837.     CrossRef
  • Local and systemic transcriptomic responses from acute exercise induced muscle damage of the human knee extensors
    Eric A. Kirk, Christina A. Castellani, Timothy J. Doherty, Charles L. Rice, Shiva M. Singh
    Physiological Genomics.2022; 54(8): 305.     CrossRef
  • Upregulation of IL‐8, osteonectin, and myonectin mRNAs by intermittent hypoxia via OCT1‐ and NRF2‐mediated mechanisms in skeletal muscle cells
    Shin Takasawa, Ryogo Shobatake, Asako Itaya‐Hironaka, Mai Makino, Tomoko Uchiyama, Sumiyo Sakuramoto‐Tsuchida, Yoshinori Takeda, Hiroyo Ota, Akiyo Yamauchi
    Journal of Cellular and Molecular Medicine.2022; 26(24): 6019.     CrossRef
  • Sarcopenia in Inflammatory Bowel Disease: A Narrative Overview
    Amritpal Dhaliwal, Jonathan I. Quinlan, Kellie Overthrow, Carolyn Greig, Janet M. Lord, Matthew J. Armstrong, Sheldon C. Cooper
    Nutrients.2021; 13(2): 656.     CrossRef
  • Role of Interleukin-6 in Vascular Health and Disease
    Paulina Villar-Fincheira, Fernanda Sanhueza-Olivares, Ignacio Norambuena-Soto, Nicole Cancino-Arenas, Felipe Hernandez-Vargas, Rodrigo Troncoso, Luigi Gabrielli, Mario Chiong
    Frontiers in Molecular Biosciences.2021;[Epub]     CrossRef
  • Computed Tomography-Derived Myosteatosis and Metabolic Disorders
    Iva Miljkovic, Chantal A. Vella, Matthew Allison
    Diabetes & Metabolism Journal.2021; 45(4): 482.     CrossRef
  • Skeletal muscle energy metabolism in obesity
    Abel M. Mengeste, Arild C. Rustan, Jenny Lund
    Obesity.2021; 29(10): 1582.     CrossRef
  • Myokines and adipomyokines: inflammatory mediators or unique molecules of targeted therapy for obesity?
    O. V. Vasyukova, Yu. V. Kasyanova, P. L. Okorokov, O. B. Bezlepkina
    Problems of Endocrinology.2021; 67(4): 36.     CrossRef
  • Associations Between Lipoprotein Subfractions and Area and Density of Abdominal Muscle and Intermuscular Adipose Tissue: The Multi-Ethnic Study of Atherosclerosis
    Megan M. Marron, Matthew Allison, Alka M. Kanaya, Britta Larsen, Alexis C. Wood, David Herrington, Philip Greenland, Iva Miljkovic
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults
    Yeliana L. Sánchez, Manuela Yepes-Calderón, Luis Valbuena, Andrés F. Milán, María C. Trillos-Almanza, Sergio Granados, Miguel Peña, Mauricio Estrada-Castrillón, Juan C. Aristizábal, Raúl Narvez-Sanchez, Jaime Gallo-Villegas, Juan C. Calderón
    Endocrinology and Metabolism.2021; 36(5): 1055.     CrossRef
  • Effects of Combined Resistance and Power Training on Cognitive Function in Older Women: A Randomized Controlled Trial
    Hélio José Coelho-Júnior, Ivan de Oliveira Gonçalves, Ricardo Aurélio Carvalho Sampaio, Priscila Yukari Sewo Sampaio, Eduardo Lusa Cadore, Riccardo Calvani, Anna Picca, Mikel Izquierdo, Emanuele Marzetti, Marco Carlos Uchida
    International Journal of Environmental Research and Public Health.2020; 17(10): 3435.     CrossRef
  • Prostate tumor–derived GDF11 accelerates androgen deprivation therapy–induced sarcopenia
    Chunliu Pan, Neha Jaiswal Agrawal, Yanni Zulia, Shalini Singh, Kai Sha, James L. Mohler, Kevin H. Eng, Joe V. Chakkalakal, John J. Krolewski, Kent L. Nastiuk
    JCI Insight.2020;[Epub]     CrossRef
  • Muscle–Organ Crosstalk: The Emerging Roles of Myokines
    Mai Charlotte Krogh Severinsen, Bente Klarlund Pedersen
    Endocrine Reviews.2020; 41(4): 594.     CrossRef
  • Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?
    Ai Guo, Kai Li, Qian Xiao
    Experimental Gerontology.2020; 139: 111022.     CrossRef
  • Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging
    Rosaly Correa-de-Araujo, Odessa Addison, Iva Miljkovic, Bret H. Goodpaster, Bryan C. Bergman, Richard V. Clark, Joanne W. Elena, Karyn A. Esser, Luigi Ferrucci, Michael O. Harris-Love, Steve B. Kritchevsky, Amanda Lorbergs, John A. Shepherd, Gerald I. Shu
    Frontiers in Physiology.2020;[Epub]     CrossRef
  • Muscle-Organ Crosstalk: Focus on Immunometabolism
    Marie Lund Bay, Bente Klarlund Pedersen
    Frontiers in Physiology.2020;[Epub]     CrossRef
  • Impact of diets rich in olive oil, palm oil or lard on myokine expression in rats
    Chantal Gauze-Gnagne, Fabrice Raynaud, Youzan Ferdinand Djohan, Céline Lauret, Christine Feillet-Coudray, Charles Coudray, Absalome Monde, Gervais Koffi, Marion Morena, Massara Camara-Cisse, Jean Paul Cristol, Eric Badia
    Food & Function.2020;[Epub]     CrossRef
  • Long-term treatment with insulin and retinoic acid increased glucose utilization in L6 muscle cells via glycogenesis
    Matthew Goff, Guoxun Chen
    Biochemistry and Cell Biology.2020; 98(6): 683.     CrossRef
  • Effects of Royal jelly on metabolic variables in diabetes mellitus: A systematic review
    Vahid Maleki, Hamed Jafari-Vayghan, Sevda Saleh-Ghadimi, Mahsa Adibian, Sorayya Kheirouri, Mohammad Alizadeh
    Complementary Therapies in Medicine.2019; 43: 20.     CrossRef
  • Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
    Sajoux, Lorenzo, Gomez-Arbelaez, Zulet, Abete, Castro, Baltar, Portillo, Tinahones, Martinez, Crujeiras, Casanueva
    Nutrients.2019; 11(10): 2368.     CrossRef
  • Extracellular Vesicles: Delivery Vehicles of Myokines
    Eleonora Trovato, Valentina Di Felice, Rosario Barone
    Frontiers in Physiology.2019;[Epub]     CrossRef
  • Effects of Exercise to Improve Cardiovascular Health
    Kelsey Pinckard, Kedryn K. Baskin, Kristin I. Stanford
    Frontiers in Cardiovascular Medicine.2019;[Epub]     CrossRef
  • Does exercise-induced apelin affect sarcopenia? A systematic review and meta-analysis
    Jun Hyun Bae, Seong Eun Kwak, Ji Hyun Lee, Zhang Yangjie, Wook Song
    Hormones.2019; 18(4): 383.     CrossRef
  • Skeletal muscle denervation investigations: selecting an experimental control wisely
    Haiming Liu, LaDora V. Thompson
    American Journal of Physiology-Cell Physiology.2019; 316(3): C456.     CrossRef
  • Myostatin Is Associated With Cognitive Decline in an Animal Model of Alzheimer’s Disease
    Yung-Shuen Lin, Fang-Yu Lin, Ya-Hsin Hsiao
    Molecular Neurobiology.2019; 56(3): 1984.     CrossRef
  • Skeletal muscle as a protagonist in the pregnancy metabolic syndrome
    Raul Narvaez-Sanchez, Juan C. Calderón, Gloria Vega, Maria Camila Trillos, Sara Ospina
    Medical Hypotheses.2019; 126: 26.     CrossRef
  • Oncostatin M, a muscle-secreted myokine, recovers high-glucose-induced impairment of Akt phosphorylation by Fos induction in hippocampal neuron cells
    William Won Seok Hyung, Sung Gon Lee, Keun Tae Kim, Hyeon Soo Kim
    NeuroReport.2019; 30(11): 765.     CrossRef
  • If my muscle could talk: Myokines as a biomarker of frailty
    Hélio J. Coelho-Junior, Anna Picca, Riccardo Calvani, Marco C. Uchida, Emanuele Marzetti
    Experimental Gerontology.2019; 127: 110715.     CrossRef
  • Impact of Sarcopenia as a Prognostic Biomarker of Bladder Cancer
    Hiroshi Fukushima, Kosuke Takemura, Hiroaki Suzuki, Fumitaka Koga
    International Journal of Molecular Sciences.2018; 19(10): 2999.     CrossRef
  • Implications of circulating Meteorin-like (Metrnl) level in human subjects with type 2 diabetes
    Hye Soo Chung, Soon Young Hwang, Ju Hee Choi, Hyun Jung Lee, Nam Hoon Kim, Hye Jin Yoo, Ji-A Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi
    Diabetes Research and Clinical Practice.2018; 136: 100.     CrossRef
  • Enhanced skeletal muscle regrowth and remodelling in massaged and contralateral non‐massaged hindlimb
    Benjamin F. Miller, Karyn L. Hamilton, Zana R. Majeed, Sarah M. Abshire, Amy L. Confides, Amanda M. Hayek, Emily R. Hunt, Patrick Shipman, Frederick F. Peelor, Timothy A. Butterfield, Esther E. Dupont‐Versteegden
    The Journal of Physiology.2018; 596(1): 83.     CrossRef
  • La funzione endocrina del muscolo scheletrico
    Francesco Marampon, Clara Crescioli
    L'Endocrinologo.2018; 19(1): 10.     CrossRef
  • RESPUESTA INFLAMATORIA Y ANTIINFLAMATORIA TRAS EL ESFUERZO AGUDO EN NATACIÓN // INFLAMMATORY AND ANTINFLAMMATOY RESPONSE AFTER SWIMMING ACUTE EFFORT
    G.A. Pussieldi, C.E. Veneroso, J.A. de Paz
    Revista Internacional de Medicina y Ciencias de la Actividad Física y del Deporte.2018; 18(71): 413.     CrossRef
  • Alpha-linolenic acid and linoleic acid differentially regulate the skeletal muscle secretome of obese Zucker rats
    Alex Rajna, Heather Gibling, Ousseynou Sarr, Sarthak Matravadia, Graham P. Holloway, David M. Mutch
    Physiological Genomics.2018; 50(8): 580.     CrossRef
  • Serum irisin associates with breast cancer to spinal metastasis
    Zheng-ping Zhang, Xue-fang Zhang, Hui Li, Tuan-jiang Liu, Qin-peng Zhao, Lin-hong Huang, Zi-jun Cao, Li-min He, Ding-jun Hao
    Medicine.2018; 97(17): e0524.     CrossRef
  • Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic
    Liliya V. Vasileva, Andrey S. Marchev, Milen I. Georgiev
    Food and Chemical Toxicology.2018; 121: 173.     CrossRef
  • Chronic inflammation and sarcopenia: A regenerative cell therapy perspective
    Jagadish K. Chhetri, Philipe de Souto Barreto, Bertrand Fougère, Yves Rolland, Bruno Vellas, Matteo Cesari
    Experimental Gerontology.2018; 103: 115.     CrossRef
  • Level of Interleukins IL-6 and IL-15 in Blood Plasma of Mice after Forced Swimming Test
    L. V. Kapilevich, T. A. Kironenko, A. N. Zakharova, A. V. Kabachkova, S. N. Orlov
    Bulletin of Experimental Biology and Medicine.2017; 163(1): 10.     CrossRef
  • Exercise Inhibits the Effects of Smoke-Induced COPD Involving Modulation of STAT3
    Maysa Alves Rodrigues Brandao-Rangel, Andre Luis Lacerda Bachi, Manoel Carneiro Oliveira-Junior, Asghar Abbasi, Adriano Silva-Renno, Auriléia Aparecida de Brito, Ana Paula Ligeiro de Oliveira, Alessandra Choqueta Toledo-Arruda, Maria Gabriela Belvisi, Rod
    Oxidative Medicine and Cellular Longevity.2017; 2017: 1.     CrossRef
  • The Need for Standardized Assessment of Muscle Quality in Skeletal Muscle Function Deficit and Other Aging-Related Muscle Dysfunctions: A Symposium Report
    Rosaly Correa-de-Araujo, Michael O. Harris-Love, Iva Miljkovic, Maren S. Fragala, Brian W. Anthony, Todd M. Manini
    Frontiers in Physiology.2017;[Epub]     CrossRef
  • Myostatin and carbohydrate disturbances
    Yavor S. Assyov, Tsvetelina V. Velikova, Zdravko A. Kamenov
    Endocrine Research.2017; 42(2): 102.     CrossRef
  • OPA 1 deficiency promotes secretion of FGF 21 from muscle that prevents obesity and insulin resistance
    Renata Oliveira Pereira, Satya M Tadinada, Frederick M Zasadny, Karen Jesus Oliveira, Karla Maria Pereira Pires, Angela Olvera, Jennifer Jeffers, Rhonda Souvenir, Rose Mcglauflin, Alec Seei, Trevor Funari, Hiromi Sesaki, Matthew J Potthoff, Christopher M
    The EMBO Journal.2017; 36(14): 2126.     CrossRef
  • Low muscle mass is associated with cardiometabolic risk regardless of nutritional status in adolescents: A cross-sectional study in a Chilean birth cohort
    R Burrows, P Correa-Burrows, M Reyes, E Blanco, C Albala, S Gahagan
    Pediatric Diabetes.2017; 18(8): 895.     CrossRef
  • Impact of sarcopenia in the management of urological cancer patients
    Hiroshi Fukushima, Fumitaka Koga
    Expert Review of Anticancer Therapy.2017; 17(5): 455.     CrossRef
  • Prognostic value of preoperative total psoas muscle area on long-term outcome in surgically treated oesophageal cancer patients
    Seong Yong Park, Joon-Kee Yoon, Su Jin Lee, Seokjin Haam, Joonho Jung
    Interactive CardioVascular and Thoracic Surgery.2017; 24(1): 13.     CrossRef
  • Nutrition and IBD: Malnutrition and/or Sarcopenia? A Practical Guide
    F. Scaldaferri, M. Pizzoferrato, L. R. Lopetuso, T. Musca, F. Ingravalle, L. L. Sicignano, M. Mentella, G. Miggiano, M. C. Mele, E. Gaetani, C. Graziani, V. Petito, G. Cammarota, E. Marzetti, A. Martone, F. Landi, A. Gasbarrini
    Gastroenterology Research and Practice.2017; 2017: 1.     CrossRef
  • Circulating Irisin Is Reduced in Male Patients with Type 1 and Type 2 Myotonic Dystrophies
    Elena Dozio, Elena Passeri, Rosanna Cardani, Stefano Benedini, Carmen Aresta, Rea Valaperta, Massimiliano Corsi Romanelli, Giovanni Meola, Valeria Sansone, Sabrina Corbetta
    Frontiers in Endocrinology.2017;[Epub]     CrossRef
  • Implication of hepatokines in metabolic disorders and cardiovascular diseases
    Tae Woo Jung, Hye Jin Yoo, Kyung Mook Choi
    BBA Clinical.2016; 5: 108.     CrossRef
  • Development of a high‐throughput method for real‐time assessment of cellular metabolism in intact long skeletal muscle fibre bundles
    Rui Li, Frederik J. Steyn, Michael B. Stout, Kevin Lee, Tanya R. Cully, Juan C. Calderón, Shyuan T. Ngo
    The Journal of Physiology.2016; 594(24): 7197.     CrossRef
  • Integrated data mining of transcriptomic and proteomic datasets to predict the secretome of adipose tissue and muscle in ruminants
    M. Bonnet, J. Tournayre, I. Cassar-Malek
    Molecular BioSystems.2016; 12(9): 2722.     CrossRef
  • CHI3L1 - a novel myokine
    H. Kainulainen
    Acta Physiologica.2016; 216(3): 260.     CrossRef
  • Elevated circulating irisin is associated with lower risk of insulin resistance: association and path analyses of obese Chinese adults
    Xiulin Shi, Mingzhu Lin, Changqin Liu, Fangsen Xiao, Yongwen Liu, Peiying Huang, Xin Zeng, Bing Yan, Suhuan Liu, Xiaoying Li, Shuyu Yang, Xuejun Li, Zhibin Li
    BMC Endocrine Disorders.2016;[Epub]     CrossRef
  • Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia
    Kyoung Min Kim, Hak Chul Jang, Soo Lim
    The Korean Journal of Internal Medicine.2016; 31(4): 643.     CrossRef
  • Relation of serum irisin level with metabolic and antropometric parameters in obese children
    Gönül Çatlı, Tuncay Küme, Hale Ünver Tuhan, Ahmet Anık, Özlem Gürsoy Çalan, Ece Böber, Ayhan Abacı
    Journal of Diabetes and its Complications.2016; 30(8): 1560.     CrossRef
Close layer
Obesity and Metabolism
Clinical Implications of Glucose Variability: Chronic Complications of Diabetes
Hye Seung Jung
Endocrinol Metab. 2015;30(2):167-174.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.167
  • 5,504 View
  • 93 Download
  • 66 Web of Science
  • 68 Crossref
AbstractAbstract PDFPubReader   

Glucose variability has been identified as a potential risk factor for diabetic complications; oxidative stress is widely regarded as the mechanism by which glycemic variability induces diabetic complications. However, there remains no generally accepted gold standard for assessing glucose variability. Representative indices for measuring intraday variability include calculation of the standard deviation along with the mean amplitude of glycemic excursions (MAGE). MAGE is used to measure major intraday excursions and is easily measured using continuous glucose monitoring systems. Despite a lack of randomized controlled trials, recent clinical data suggest that long-term glycemic variability, as determined by variability in hemoglobin A1c, may contribute to the development of microvascular complications. Intraday glycemic variability is also suggested to accelerate coronary artery disease in high-risk patients.

Citations

Citations to this article as recorded by  
  • A randomized trial on the effect of transcutaneous electrical nerve stimulator on glycemic control in patients with type 2 diabetes
    Jin-Ying Lu, Horng-Yih Ou, Chung-Ze Wu, Chwen-Yi Yang, Ju-Ying Jiang, Chieh-Hsiang Lu, Yi-Der Jiang, Tien-Jyun Chang, Yi-Cheng Chang, Meng-Lun Hsieh, Wan-Chen Wu, Hung-Yuan Li, Ye-Fong Du, Ching-Han Lin, Hao-Chang Hung, Kai-Jen Tien, Nai-Cheng Yeh, Shang-
    Scientific Reports.2023;[Epub]     CrossRef
  • Association between initial in-hospital heart rate and glycemic control in patients with acute ischemic stroke and diabetes mellitus
    Ya-Wen Kuo, Jiann-Der Lee, Chuan-Pin Lee, Yen-Chu Huang, Meng Lee
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • Practical Application of Continuous Glucose Monitoring in Clinical Practice: Case Studies
    Jeff Unger, Denise R. Franco
    Diabetes Technology & Therapeutics.2023; 25(S3): S-21.     CrossRef
  • Comparison of Glycemia Risk Index with Time in Range for Assessing Glycemic Quality
    Ji Yoon Kim, Jee Hee Yoo, Jae Hyeon Kim
    Diabetes Technology & Therapeutics.2023; 25(12): 883.     CrossRef
  • Personalized diabetes monitoring platform leveraging IoMT and AI for non-invasive estimation
    Durga Padmavilochanan, Rahul Krishnan Pathinarupothi, K.A. Unnikrishna Menon, Harish Kumar, Ramesh Guntha, Maneesha V. Ramesh, P. Venkat Rangan
    Smart Health.2023; 30: 100428.     CrossRef
  • Acute effects of drinks containing blackcurrant and citrus (poly)phenols and dietary fibre on postprandial glycaemia, gut hormones, cognitive function and appetite in healthy adults: two randomised controlled trials
    Ana M. Pinto, Mark R. Hobden, Katherine D. Brown, Jonathan Farrimond, Darren Targett, Christopher P. Corpe, Peter R. Ellis, Yvanna Todorova, Klaudia Socha, Shatha Bahsoon, Claudia Haworth, Morgane Marcel, Xirui Nie, Wendy L. Hall
    Food & Function.2023; 14(22): 10163.     CrossRef
  • Metabolomics in diabetes mellitus: clinical insight
    Shereen M. Aleidi, Hiba Al Fahmawi, Afshan Masood, Anas Abdel Rahman
    Expert Review of Proteomics.2023; 20(12): 451.     CrossRef
  • Effects of Teneligliptin on HbA1c levels, Continuous Glucose Monitoring-Derived Time in Range and Glycemic Variability in Elderly Patients with T2DM (TEDDY Study)
    Ji Cheol Bae, Soo Heon Kwak, Hyun Jin Kim, Sang-Yong Kim, You-Cheol Hwang, Sunghwan Suh, Bok Jin Hyun, Ji Eun Cha, Jong Chul Won, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2022; 46(1): 81.     CrossRef
  • Glycemic Variability and Diabetes Mellitus
    Han Na Jang, Hye Seung Jung
    The Journal of Korean Diabetes.2022; 23(1): 12.     CrossRef
  • Comparison of the Impact of Insulin Degludec U100 and Insulin Glargine U300 on Glycemic Variability and Oxidative Stress in Insulin-Naive Patients With Type 2 Diabetes Mellitus: Pilot Study for a Randomized Trial
    Pavle Vrebalov Cindro, Mladen Krnić, Darko Modun, Jonatan Vuković, Tina Tičinović Kurir, Goran Kardum, Doris Rušić, Ana Šešelja Perišin, Josipa Bukić
    JMIR Formative Research.2022; 6(7): e35655.     CrossRef
  • Endothelial Dysfunction and Platelet Hyperactivation in Diabetic Complications Induced by Glycemic Variability
    Ye Huang, Long Yue, Jiahuang Qiu, Ming Gao, Sijin Liu, Jingshang Wang
    Hormone and Metabolic Research.2022; 54(07): 419.     CrossRef
  • Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective
    Wei Yu, Iqra Ilyas, Xuerui Hu, Suowen Xu, Hui Yu
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Effect of Dapagliflozin as an Add-on Therapy to Insulin on the Glycemic Variability in Subjects with Type 2 Diabetes Mellitus (DIVE): A Multicenter, Placebo-Controlled, Double-Blind, Randomized Study
    Seung-Hwan Lee, Kyung-Wan Min, Byung-Wan Lee, In-Kyung Jeong, Soon-Jib Yoo, Hyuk-Sang Kwon, Yoon-Hee Choi, Kun-Ho Yoon
    Diabetes & Metabolism Journal.2021; 45(3): 339.     CrossRef
  • Association of time in range, as assessed by continuous glucose monitoring, with painful diabetic polyneuropathy
    Junpeng Yang, Xueli Yang, Dongni Zhao, Xiaobing Wang, Wei Wei, Huijuan Yuan
    Journal of Diabetes Investigation.2021; 12(5): 828.     CrossRef
  • The Association Between Continuous Glucose Monitoring-Derived Metrics and Cardiovascular Autonomic Neuropathy in Outpatients with Type 2 Diabetes
    Min Young Kim, Gyuri Kim, Ji Yun Park, Min Sun Choi, Ji Eun Jun, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
    Diabetes Technology & Therapeutics.2021; 23(6): 434.     CrossRef
  • Current concepts and clinical importance of glycemic variability
    Ramya Ravi, V Balasubramaniam, Gowthamarajan Kuppusamy, Sivasankaran Ponnusankar
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2021; 15(2): 627.     CrossRef
  • Glycemic deviation index: a novel method of integrating glycemic numerical value and variability
    Yizhou Zou, Wanli Wang, Dongmei Zheng, Xu Hou
    BMC Endocrine Disorders.2021;[Epub]     CrossRef
  • Relationship between short and long-term glycemic variability and oxidative stress in type 1 diabetes mellitus under daily life insulin treatment
    Tatiana Valente, Fernando Valente, Maria Beatriz Bastos Lucchesi, Giovana Rita Punaro, Margaret Gori Mouro, Monica Andrade Lima Gabbay, Elisa Mieko Suemitsu Higa, Sergio Atala Dib
    Archives of Endocrinology and Metabolism.2021;[Epub]     CrossRef
  • Evidence of Early Diabetic Nephropathy in Pediatric Type 1 Diabetes
    Leena Mamilly, Lucy D. Mastrandrea, Claudia Mosquera Vasquez, Brett Klamer, Mahmoud Kallash, Ahmad Aldughiem
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Glucose Variability and Risk of Hepatocellular Carcinoma in Patients with Diabetes: A Nationwide Population-Based Study
    Jeong-Ju Yoo, Eun Ju Cho, Kyungdo Han, Soo Seong Heo, Bo-Yeon Kim, Dong Wook Shin, Su Jong Yu
    Cancer Epidemiology, Biomarkers & Prevention.2021; 30(5): 974.     CrossRef
  • Effect of glucose concentration and culture substrate on HUVECs viability in in vitro cultures: A literature review and own results
    Anna Ciechanowska, Ilona Gora, Stanislawa Sabalinska, Piotr Foltynski, Piotr Ladyzynski
    Biocybernetics and Biomedical Engineering.2021; 41(4): 1390.     CrossRef
  • Time to Reach Target Glycosylated Hemoglobin Is Associated with Long-Term Durable Glycemic Control and Risk of Diabetic Complications in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A 6-Year Observational Study
    Kyoung Jin Kim, Jimi Choi, Jae Hyun Bae, Kyeong Jin Kim, Hye Jin Yoo, Ji A Seo, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Sin Gon Kim, Nam Hoon Kim
    Diabetes & Metabolism Journal.2021; 45(3): 368.     CrossRef
  • Immunosuppressive PLGA TGF-β1 Microparticles Induce Polyclonal and Antigen-Specific Regulatory T Cells for Local Immunomodulation of Allogeneic Islet Transplants
    Ying Li, Anthony W. Frei, Irayme M. Labrada, Yanan Rong, Jia-Pu Liang, Magdalena M. Samojlik, Chuqiao Sun, Steven Barash, Benjamin G. Keselowsky, Allison L. Bayer, Cherie L. Stabler
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Retrospective study of glycemic variability, BMI, and blood pressure in diabetes patients in the Digital Twin Precision Treatment Program
    Paramesh Shamanna, Mala Dharmalingam, Rakesh Sahay, Jahangir Mohammed, Maluk Mohamed, Terrence Poon, Nathan Kleinman, Mohamed Thajudeen
    Scientific Reports.2021;[Epub]     CrossRef
  • Dulaglutide improves muscle function by attenuating inflammation through OPA-1-TLR-9 signaling in aged mice
    Phyu Phyu Khin, Yeonhee Hong, MyeongHoon Yeon, Dae Ho Lee, Jong Han Lee, Hee-Sook Jun
    Aging.2021; 13(18): 21962.     CrossRef
  • Glycemic Variability, Oxidative Stress, and Impact on Complications Related to Type 2 Diabetes Mellitus
    Tatiana Valente, Alberto K. Arbex
    Current Diabetes Reviews.2021;[Epub]     CrossRef
  • The impact of structured self-monitoring of blood glucose on glycaemic variability in non-insulin treated type 2 diabetes: The SMBG study, a 12-month randomised controlled trial
    David M. Williams, Sharon N. Parsons, Gareth J. Dunseath, Jeffrey W. Stephens, Stephen D. Luzio, David R. Owens
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(2): 101.     CrossRef
  • Model‐based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine
    Emma C. E. Meessen, Fianne L. P. Sips, Hannah M. Eggink, Martijn Koehorst, Johannes A. Romijn, Albert K. Groen, Natal A. W. Riel, Maarten R. Soeters
    Physiological Reports.2020;[Epub]     CrossRef
  • How tightly controlled do fluctuations in blood glucose levels need to be to reduce the risk of developing complications in people with Type 1 diabetes?
    R. Livingstone, J. G. Boyle, J. R. Petrie
    Diabetic Medicine.2020; 37(4): 513.     CrossRef
  • Simple Linear Support Vector Machine Classifier Can Distinguish Impaired Glucose Tolerance Versus Type 2 Diabetes Using a Reduced Set of CGM-Based Glycemic Variability Indices
    Enrico Longato, Giada Acciaroli, Andrea Facchinetti, Alberto Maran, Giovanni Sparacino
    Journal of Diabetes Science and Technology.2020; 14(2): 297.     CrossRef
  • Vascular Complication in Adolescents With Diabetes Mellitus
    Lara E. Graves, Kim C. Donaghue
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • The Association Between Glycemic Variability and Macronutrients in Young Children with T1D
    Alexandra D Monzon, Laura B Smith, Scott W Powers, Lawrence M Dolan, Susana R Patton
    Journal of Pediatric Psychology.2020; 45(7): 749.     CrossRef
  • Effect of sancai powder on glacemic variability of type 1 diabetes in China
    Weiwei Yu, Dongqi Zhou, Li Zhang, Chen Rumeng, Peishuai Zhang, Lisha Sun, Ziping Gao
    Medicine.2020; 99(34): e20772.     CrossRef
  • Glycemic variability in newly diagnosed diabetic cats treated with the glucagon‐like peptide‐1 analogue exenatide extended release
    Anna L. Krämer, Angelina Riederer, Federico Fracassi, Felicitas S. Boretti, Nadja S. Sieber‐Ruckstuhl, Thomas A. Lutz, Barbara Contiero, Eric Zini, Claudia E. Reusch
    Journal of Veterinary Internal Medicine.2020; 34(6): 2287.     CrossRef
  • The Association Between Glycemic Variability and Myocardial Infarction: A Review and Meta-Analysis of Prospective Studies and Randomized Trials
    Zinab Alatawi, Hyder Mirghani
    Cureus.2020;[Epub]     CrossRef
  • Epigenetic regulation by polyphenols in diabetes and related complications
    Hammad Ullah, Anna De Filippis, Cristina Santarcangelo, Maria Daglia
    Mediterranean Journal of Nutrition and Metabolism.2020; 13(4): 289.     CrossRef
  • A Protective Role of Paeoniflorin in Fluctuant Hyperglycemia-Induced Vascular Endothelial Injuries through Antioxidative and Anti-Inflammatory Effects and Reduction of PKCβ1
    Jing-Shang Wang, Ye Huang, Shuping Zhang, Hui-Jun Yin, Lei Zhang, Yan-Hong Zhang, Ye-Wen Song, Dan-Dan Li
    Oxidative Medicine and Cellular Longevity.2019; 2019: 1.     CrossRef
  • The mechanisms of glycemic variability accelerate diabetic central neuropathy and diabetic peripheral neuropathy in diabetic rats
    Junpeng Yang, Zhigang Zhao, Huijuan Yuan, Xiangxiang Ma, Yakun Li, Huimeng Wang, Xiaojun Ma, Guijun Qin
    Biochemical and Biophysical Research Communications.2019; 510(1): 35.     CrossRef
  • Glucose Variability and Coronary Artery Disease
    Jinggang Xia, Chunlin Yin
    Heart, Lung and Circulation.2019; 28(4): 553.     CrossRef
  • Phase 1 Study of the Pharmacology of BTI320 Before High‐Glycemic Meals
    David R. Luke, Karen Ka Yan Lee, Carl W. Rausch, Camille Cheng
    Clinical Pharmacology in Drug Development.2019; 8(3): 395.     CrossRef
  • Information Technology for Supporting Self-Control in the Formation of a Rational Lifestyle for Diabetics Patients
    S. KIFORENKO, T. HONTAR, V. ORLENKO, K. IVASKIVA, T. OBELETS
    Kibernetika i vyčislitelʹnaâ tehnika.2019; 2019(3(197)): 80.     CrossRef
  • Impact of Carbohydrate on Glucose Variability in Patients with Type 1 Diabetes Assessed Through Professional Continuous Glucose Monitoring: A Retrospective Study
    Yi-Hsuan Lin, Yu-Yao Huang, Hsin-Yun Chen, Sheng-Hwu Hsieh, Jui-Hung Sun, Szu-Tah Chen, Chia-Hung Lin
    Diabetes Therapy.2019; 10(6): 2289.     CrossRef
  • Tracking the Sugar Rush: Incorporating Continuous Glucose Monitoring Into Multisite Early Clinical Research With Type 2 Diabetes Subjects
    Sabina Paglialunga, Bruce H. Morimoto, Amparo de la Peña, Caroline Fortier
    Clinical Pharmacology in Drug Development.2018; 7(7): 676.     CrossRef
  • Higher Total Insulin Dose Has Positive Effect on Corneal Nerve Fibers in DM1 Patients
    Gabriela Mahelková, Marie Ceská Burdová, Šárka Malá, Lucie Hoskovcová, Dagmar Dotrelová, Katerina Štechová
    Investigative Opthalmology & Visual Science.2018; 59(10): 3800.     CrossRef
  • Relationship between Thyroid Function and Kidney Function in Patients with Type 2 Diabetes
    Ying Zhang, Yang Wang, Xiao Jun Tao, Qian Li, Feng Fei Li, Kok Onn Lee, Dong Mei Li, Jian Hua Ma
    International Journal of Endocrinology.2018; 2018: 1.     CrossRef
  • The correlation between glucose fluctuation from self-monitored blood glucose and the major adverse cardiac events in diabetic patients with acute coronary syndrome during a 6-month follow-up by WeChat application
    Jinggang Xia, Shaodong Hu, Ji Xu, Hengjian Hao, Chunlin Yin, Dong Xu
    Clinical Chemistry and Laboratory Medicine (CCLM).2018; 56(12): 2119.     CrossRef
  • Glycemic Variability Percentage: A Novel Method for Assessing Glycemic Variability from Continuous Glucose Monitor Data
    Thomas A. Peyser, Andrew K. Balo, Bruce A. Buckingham, Irl B. Hirsch, Arturo Garcia
    Diabetes Technology & Therapeutics.2018; 20(1): 6.     CrossRef
  • Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo-controlled clinical trial
    Han Seok Choi, Sunmi Kim, Min Jung Kim, Myung-Sunny Kim, Juewon Kim, Chan-Woong Park, Daebang Seo, Song Seok Shin, Sang Woo Oh
    Journal of Ginseng Research.2018; 42(1): 90.     CrossRef
  • Resistance to Data Loss of Glycemic Variability Measurements in Long-Term Continuous Glucose Monitoring
    Przemysław Kucharski, Konrad Pagacz, Agnieszka Szadkowska, Wojciech Młynarski, Andrzej Romanowski, Wojciech Fendler
    Diabetes Technology & Therapeutics.2018; 20(12): 833.     CrossRef
  • Investigation of glucose fluctuations by approaches of multi-scale analysis
    Yunyun Lai, Zhengbo Zhang, Peiyao Li, Xiaoli Liu, YiXin Liu, Yi Xin, Weijun Gu
    Medical & Biological Engineering & Computing.2018; 56(3): 505.     CrossRef
  • Shared Responsibility for Type 1 Diabetes Care Is Associated With Glycemic Variability and Risk of Glycemic Excursions in Youth
    Arwen M Marker, Amy E Noser, Mark A Clements, Susana R Patton
    Journal of Pediatric Psychology.2018; 43(1): 61.     CrossRef
  • Self Blood Glucose Monitoring Underestimates Hyperglycemia And Hypoglycemia As Compared To Continuous Glucose Monitoring In Type 1 And Type 2 Diabetes
    Devna Mangrola, Christine Cox, Arianne S. Furman, Sridevi Krishnan, Sidika E. Karakas
    Endocrine Practice.2018; 24(1): 47.     CrossRef
  • Risk factors for the development of micro-vascular complications of type 2 diabetes in a single-centre cohort of patients
    Marsida Teliti, Giulia Cogni, Lucia Sacchi, Arianna Dagliati, Simone Marini, Valentina Tibollo, Pasquale De Cata, Riccardo Bellazzi, Luca Chiovato
    Diabetes and Vascular Disease Research.2018; 15(5): 424.     CrossRef
  • Glucotypes reveal new patterns of glucose dysregulation
    Heather Hall, Dalia Perelman, Alessandra Breschi, Patricia Limcaoco, Ryan Kellogg, Tracey McLaughlin, Michael Snyder, Jason Locasale
    PLOS Biology.2018; 16(7): e2005143.     CrossRef
  • Glucose Outcomes with the In-Home Use of a Hybrid Closed-Loop Insulin Delivery System in Adolescents and Adults with Type 1 Diabetes
    Satish K. Garg, Stuart A. Weinzimer, William V. Tamborlane, Bruce A. Buckingham, Bruce W. Bode, Timothy S. Bailey, Ronald L. Brazg, Jacob Ilany, Robert H. Slover, Stacey M. Anderson, Richard M. Bergenstal, Benyamin Grosman, Anirban Roy, Toni L. Cordero, J
    Diabetes Technology & Therapeutics.2017; 19(3): 155.     CrossRef
  • Vildagliptin reduces plasma stromal cell‐derived factor‐1α in patients with type 2 diabetes compared with glimepiride
    Kyeong Seon Park, SooHeon Kwak, Young Min Cho, Kyong Soo Park, Hak C Jang, Seong Yeon Kim, Hye Seung Jung
    Journal of Diabetes Investigation.2017; 8(2): 218.     CrossRef
  • Role of the PKCβII/JNK signaling pathway in acute glucose fluctuation-induced apoptosis of rat vascular endothelial cells
    Na Wu, Haitao Shen, Yanjun Wang, Bing He, Yongyan Zhang, Yu Bai, Runyu Du, Qiang Du, Ping Han
    Acta Diabetologica.2017; 54(8): 727.     CrossRef
  • Association between glycemic variability and major adverse cardiovascular and cerebrovascular events (MACCE) in patients with acute coronary syndrome during 30-day follow-up
    Jinggang Xia, Ji Xu, Boyu Li, Zhi Liu, Hengjian Hao, Chunlin Yin, Dong Xu
    Clinica Chimica Acta.2017; 466: 162.     CrossRef
  • How Can We Realize the Clinical Benefits of Continuous Glucose Monitoring?
    Ramzi A. Ajjan
    Diabetes Technology & Therapeutics.2017; 19(S2): S-27.     CrossRef
  • The efficacy and safety of adding either vildagliptin or glimepiride to ongoing metformin therapy in patients with type 2 diabetes mellitus
    Gyuri Kim, Sewon Oh, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim, Moon-Kyu Lee
    Expert Opinion on Pharmacotherapy.2017; 18(12): 1179.     CrossRef
  • Association Between Coronary Artery Calcification and the Hemoglobin Glycation Index: The Kangbuk Samsung Health Study
    Eun-Jung Rhee, Jung-Hwan Cho, Hyemi Kwon, Se Eun Park, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
    The Journal of Clinical Endocrinology & Metabolism.2017; 102(12): 4634.     CrossRef
  • Glucose variability for cardiovascular risk factors in type 2 diabetes: a meta-analysis
    Shuang Liang, Hang Yin, Chunxiang Wei, Linjun Xie, Hua He, Xiaoquan Liu
    Journal of Diabetes & Metabolic Disorders.2017;[Epub]     CrossRef
  • Could angiotensin-(1–7) be connected with improvement of microvascular function in diabetic patients? Angiotensin-(1–7) iontophoresis may provide the answer
    Aleksandar Kibel
    Medical Hypotheses.2016; 93: 16.     CrossRef
  • Efficacy and Safety of PDM011011 Capsules as Compared to Metformin in Subjects with Type-2 Diabetes Mellitus: An Open-Label, Randomized, Active-Controlled, Multicentric, Phase III Study
    Ashish C. Suthar, Vikas G. Pai, Yogesh Kadam, Aniruddha Tongaonkar, Shailaja Kale, Atul B. Deshpande, Sharat Kolke, Snehal Tanna, Shrikant V. Deshpande, Purvi Chawla, Debjit Biswas, Somesh Sharma
    Journal of Diabetes Mellitus.2016; 06(01): 38.     CrossRef
  • 1,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin Therapy
    Min Kyeong Kim, Hye Seung Jung, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Seong Yeon Kim
    Endocrinology and Metabolism.2016; 31(2): 284.     CrossRef
  • The impact of glycemic variability on diabetic peripheral neuropathy
    Heung Yong Jin, Kyung Ae Lee, Tae Sun Park
    Endocrine.2016; 53(3): 643.     CrossRef
  • Serum bilirubin levels are positively associated with glycemic variability in women with type 2 diabetes
    Lee Kyung Kim, Eun Roh, Min Joo Kim, Min Kyeong Kim, Kyeong Seon Park, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Hak Chul Jang, Hye Seung Jung
    Journal of Diabetes Investigation.2016; 7(6): 874.     CrossRef
  • Wider Perioperative Glycemic Fluctuations Increase Risk of Postoperative Acute Kidney Injury
    Ming Ann Sim, Weiling Liu, Roderica R.G. Ng, Lian Kah Ti, Sophia T.H. Chew
    Medicine.2015; 94(44): e1953.     CrossRef
Close layer
Calcium and Cardiovascular Disease
Ian R. Reid, Sarah M. Birstow, Mark J. Bolland
Endocrinol Metab. 2017;32(3):339-349.   Published online September 18, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.3.339
  • 9,741 View
  • 121 Download
  • 69 Web of Science
  • 67 Crossref
AbstractAbstract PDFPubReader   

Circulating calcium is a risk factor for vascular disease, a conclusion arising from prospective studies involving hundreds of thousands of participants and extending over periods of up to 30 years. These associations may be partially mediated by other cardiovascular risk factors such as circulating lipid levels, blood pressure, and body mass index, but there appears to be a residual independent effect of serum calcium. Polymorphisms of the calcium-sensing receptor associated with small elevations of serum calcium are also associated with cardiovascular disease, suggesting that calcium plays a causative role. Trials of calcium supplements in patients on dialysis and those with less severe renal failure demonstrate increased mortality and/or acceleration of vascular disease, and meta-analyses of trials in those without overt renal disease suggest a similar adverse effect. Interpretation of the latter trials is complicated by a significant interaction between baseline use of calcium supplements and the effect of randomisation to calcium in the largest trial. Restriction of analysis to those who are calcium-naive demonstrates a consistent adverse effect. Observational studies of dietary calcium do not demonstrate a consistent adverse effect on cardiovascular health, though very high or very low intakes may be deleterious. Thus, obtaining calcium from the diet rather than supplements is to be encouraged.

Citations

Citations to this article as recorded by  
  • Cardiovascular and Cerebrovascular Outcomes With Vitamin D Supplementation: A Systematic Review and Meta-Analysis
    Jishanth Mattumpuram, Muhammad Talha Maniya, Sabeeh Khawar Faruqui, Aymen Ahmed, Vikash Jaiswal, Sreedevi Pallath Harshakumar
    Current Problems in Cardiology.2024; 49(1): 102119.     CrossRef
  • 43Ca MAS-DNP NMR of Frozen Solutions for the Investigation of Calcium Ion Complexation
    Tristan Georges, Romain Chèvre, Samuel F. Cousin, Christel Gervais, Pierre Thureau, Giulia Mollica, Thierry Azaïs
    ACS Omega.2024; 9(4): 4881.     CrossRef
  • Case Series Analysis of Chronic Venous Insufficiency Patients to Determine Associated Arthrosis
    Malay Patel, Roy Varghese, Manjusha Rajarshi
    Indian Journal of Surgery.2023; 85(S1): 106.     CrossRef
  • Prevalence of asteroid hyalosis and systemic risk factors in United States adults
    Ryan Duong, Xiaoyu Cai, Naveen Ambati, Yevgeniy Shildkrot, Rebecca Sieburth
    Eye.2023; 37(8): 1678.     CrossRef
  • L-shaped association of serum calcium with all-cause and CVD mortality in the US adults: A population-based prospective cohort study
    Xinran Hou, Jie Hu, Zhuoyi Liu, E. Wang, Qulian Guo, Zhong Zhang, Zongbin Song
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • The genetic correlation and causal association between key factors that influence vascular calcification and cardiovascular disease incidence
    Xiaolin Ni, Lei Liu, Yao Yao, Chi Zhang, Huabin Su, Yuan Lv, Rongqiao Li, Liang Sun, Qi Zhou, Xiaoquan Zhu, Ze Yang, Zuoguan Chen, Wei He, Huolan Zhu, Shenqi Zhang, Caiyou Hu, Huiping Yuan
    Frontiers in Cardiovascular Medicine.2023;[Epub]     CrossRef
  • The association of long-term calcium and dairy products intake in adolescence with carotid intima media thickness and metabolic syndrome in early adulthood: Tehran Lipid and Glucose Study
    Assa AkbarySedigh, Golaleh Asghari, Maryam Mahdavi, Parvin Mirmiran, Majid Valizadeh, Fereidoun Azizi
    Nutrition & Metabolism.2023;[Epub]     CrossRef
  • Effect Modification of Kidney Function on the Non-linear Association Between Serum Calcium Levels and Cardiovascular Mortality in Korean Adults
    Jung-Ho Yang, Sun-Seog Kweon, Young-Hoon Lee, Seong-Woo Choi, So-Yeon Ryu, Hae-Sung Nam, Hye-Yeon Kim, Min-Ho Shin
    Journal of Preventive Medicine and Public Health.2023; 56(3): 282.     CrossRef
  • The Relationship between Mortality from Cardiovascular Diseases and Total Drinking Water Hardness: Systematic Review with Meta-Analysis
    Aleksandra Bykowska-Derda, Marcin Spychala, Magdalena Czlapka-Matyasik, Mariusz Sojka, Jerzy Bykowski, Mariusz Ptak
    Foods.2023; 12(17): 3255.     CrossRef
  • Association Between Calcium Supplementation and the Risk of Cardiovascular Disease and Stroke: A Systematic Review and Meta-Analysis
    Ming Gin Sim, Yao Neng Teo, Yao Hao Teo, Nicholas L. Syn, Tony Y.W. Li, Leonard L.L. Yeo, William K.F. Kong, Benjamin Y.Q. Tan, James W. Yip, Raymond C.C. Wong, Kian Keong Poh, Tiong-Cheng Yeo, Vijay Kumar Sharma, Ping Chai, Mark Y. Chan, Ching-Hui Sia
    Heart, Lung and Circulation.2023; 32(10): 1230.     CrossRef
  • Omega-3 long-chain polyunsaturated fatty acids: Metabolism and health implications
    Imad Khan, Mudassar Hussain, Bangzhi Jiang, Lei Zheng, Yuechao Pan, Jijie Hu, Adil Khan, Azqa Ashraf, Xiaoqiang Zou
    Progress in Lipid Research.2023; 92: 101255.     CrossRef
  • The role of chromium supplementation in cardiovascular risk factors: A comprehensive reviews of putative molecular mechanisms
    Dhiaa lattef Gossa Al-Saadde, Ali Murtaza Haider, Arsalan Ali, Ebraheem Abdu Musad Saleh, Abduladheem Turki Jalil, Furqan M. Abdulelah, Rosario Mireya Romero-Parra, Nahla A. Tayyib, Andrés Alexis Ramírez-Coronel, Ameer S. Alkhayyat
    Heliyon.2023; 9(9): e19826.     CrossRef
  • Calcium as an essential macronutrient: benefits and risks for cardiovascular and other body systems
    A.V. Gostry, R.A. Bekker, Yu.V. Bykov
    Profilakticheskaya meditsina.2023; 26(10): 109.     CrossRef
  • Association of Genotypes of ANGPTL3 with Vitamin D and Calcium Concentration in Cardiovascular Disease
    Malihe Aghasizadeh, Mahmoud Ghanei, Sahar Ghoflchi, Parisa Asadian-sohan, Mohammad Haghani, Tooba Kazemi, Habibollah Esmaily, Amir Avan, Gordon A. Ferns, Ebrahim Miri-Moghaddam, Majid Ghayour-Mobarhan
    Biochemical Genetics.2023;[Epub]     CrossRef
  • Bone-friendly lifestyle and the role of calcium or vitamin D supplementation
    I. R. Reid
    Climacteric.2022; 25(1): 37.     CrossRef
  • Cardiovascular risks associated with calcium supplementation in patients with osteoporosis: a nationwide cohort study
    Kyoung Jin Kim, Min Sun Kim, Namki Hong, Jae Hyun Bae, Kyeong Jin Kim, Nam Hoon Kim, Yumie Rhee, Juneyoung Lee, Sin Gon Kim
    European Heart Journal - Cardiovascular Pharmacotherapy.2022; 8(6): 568.     CrossRef
  • Cyclic voltammetric determination of calcium in water in the presence of natural organic matter (humic acid) and Cu (II) at gold electrode's surface
    Olayemi J. Fakayode, Thabo T.I. Nkambule
    Food Chemistry Advances.2022; 1: 100012.     CrossRef
  • Low serum concentration of zinc, selenium, calcium, potassium and high serum concentration of iron, sodium are associated with myocardial infarction
    S. M. Naim Uddin, Md. Zahedur Rahaman, Thanmin Jarana Thammi, Mohammad Rashedul Islam, Md. Iftikhar Uddin Masud, Md. Giash Uddin, Mohammad Safiqul Islam
    Aging and Health Research.2022; 2(1): 100063.     CrossRef
  • Organelle-specific blue-emitting two-photon probes for calcium ions: Combination with green-emitting two-photon probe for simultaneous detection of proton ions
    Seung Taek Hong, Mun Seok Kim, Bo Ra Kim, Eun Jeong Lee, Yeo Uk Yoon, Kyu Cheol Paik, Man So Han, Eun Sun Kim, Bong Rae Cho
    Talanta.2022; 244: 123408.     CrossRef
  • Plasma Calcium and Phosphorus Levels and Cardiovascular Disease Risks in Egyptian Type 2 Diabetic Patients
    Sahar Al-Okbi, Seham Sabry, Enas S. K. Al-Siedy, Shaimaa Elsayed
    Open Access Macedonian Journal of Medical Sciences.2022; 10(A): 502.     CrossRef
  • The Incidence of Serum Calcium Elevation due to Adrenal Insufficiency After Unilateral Adrenalectomy
    Woochul Kim, Jee-Hye Choi, Ja Kyung Lee, Chang Ho Ahn, Hyeong Won Yu, June Young Choi
    Journal of Endocrine Surgery.2022; 22(1): 18.     CrossRef
  • Calcium Supplementation, Risk of Cardiovascular Diseases, and Mortality: A Real-World Study of the Korean National Health Insurance Service Data
    Jae-Min Park, Bora Lee, Young-Sang Kim, Kyung-Won Hong, Yon Chul Park, Dong Hyeok Shin, Yonghwan Kim, Kunhee Han, Kwangyoon Kim, Junghwa Shin, Mina Kim, Bom-Taeck Kim
    Nutrients.2022; 14(12): 2538.     CrossRef
  • Physical Fitness and Dietary Intake Improve Mental Health in Chinese Adolescence Aged 12–13
    Wenjie Liang, Jian Fu, Xin Tian, Jiaxue Tian, Yu Yang, Wencui Fan, Zijuan Du, Zheyu Jin
    Frontiers in Integrative Neuroscience.2022;[Epub]     CrossRef
  • EXTENSIVE EXPERTISE IN ENDOCRINOLOGY: Osteoporosis management
    Ian R Reid
    European Journal of Endocrinology.2022; 187(4): R65.     CrossRef
  • Evaluation of the Increase in Serum Calcium Levels After Unilateral Adrenalectomy
    Mehmet Üstün, Korhan Tuncer
    Cureus.2022;[Epub]     CrossRef
  • Comparing the Evidence from Observational Studies and Randomized Controlled Trials for Nonskeletal Health Effects of Vitamin D
    William B. Grant, Barbara J. Boucher, Fatme Al Anouti, Stefan Pilz
    Nutrients.2022; 14(18): 3811.     CrossRef
  • Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: Role of mitochondria
    Yan Zhong Liu, Zong Xiang Li, Lin Lin Zhang, Dan Wang, Yi Ping Liu
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Association between serum calcium level and in-hospital mortality in patients with acute myocardial infarction: a retrospective cohort study
    Dingfeng Fang, Haibo Chen
    Scientific Reports.2022;[Epub]     CrossRef
  • Calcium and vitamin D supplements for the treatment and prevention of osteoporosis. Should it be widely used?
    Yuliya A. Kaminarskaya
    Clinical nutrition and metabolism.2022; 3(3): 167.     CrossRef
  • Calcium Signalling in Heart and Vessels: Role of Calmodulin and Downstream Calmodulin-Dependent Protein Kinases
    Sofia Beghi, Malgorzata Furmanik, Armand Jaminon, Rogier Veltrop, Nikolas Rapp, Kanin Wichapong, Elham Bidar, Annamaria Buschini, Leon J. Schurgers
    International Journal of Molecular Sciences.2022; 23(24): 16139.     CrossRef
  • Childhood and long-term dietary calcium intake and adult cardiovascular risk in a population with high calcium intake
    Feitong Wu, Katja Pahkala, Markus Juonala, Suvi P. Rovio, Matthew A. Sabin, Tapani Rönnemaa, Kylie J. Smith, Antti Jula, Terho Lehtimäki, Nina Hutri-Kähönen, Mika Kähönen, Tomi Laitinen, Jorma S.A. Viikari, Olli T. Raitakari, Costan G. Magnussen
    Clinical Nutrition.2021; 40(4): 1926.     CrossRef
  • Collagen networks within 3D PEG hydrogels support valvular interstitial cell matrix mineralization
    Megan E. Schroeder, Andrea Gonzalez Rodriguez, Kelly F. Speckl, Cierra J. Walker, Firaol S. Midekssa, Joseph C. Grim, Robert M. Weiss, Kristi S. Anseth
    Acta Biomaterialia.2021; 119: 197.     CrossRef
  • Effects of High-Impact Weight-Bearing Exercise on Bone Mineral Density and Bone Metabolism in Middle-Aged Premenopausal Women: A Randomized Controlled Trial
    Sung-Woo Kim, Myong-Won Seo, Hyun-Chul Jung, Jong-Kook Song
    Applied Sciences.2021; 11(2): 846.     CrossRef
  • Higher Intakes of Potassium and Magnesium, but Not Lower Sodium, Reduce Cardiovascular Risk in the Framingham Offspring Study
    R. Taylor Pickering, M. Loring Bradlee, Martha R. Singer, Lynn L. Moore
    Nutrients.2021; 13(1): 269.     CrossRef
  • Low serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry
    Timo Schmitz, Christian Thilo, Jakob Linseisen, Margit Heier, Annette Peters, Bernhard Kuch, Christa Meisinger
    Scientific Reports.2021;[Epub]     CrossRef
  • Edible Insects versus Meat—Nutritional Comparison: Knowledge of Their Composition Is the Key to Good Health
    Agnieszka Orkusz
    Nutrients.2021; 13(4): 1207.     CrossRef
  • The Role of Essential Oils and Their Main Compounds in the Management of Cardiovascular Disease Risk Factors
    Jorge M. Alves-Silva, Mónica Zuzarte, Henrique Girão, Lígia Salgueiro
    Molecules.2021; 26(12): 3506.     CrossRef
  • Polymorphism rs7214723 in CAMKK1: a new genetic variant associated with cardiovascular diseases
    Sofia Beghi, Francesca Cavaliere, Matteo Manfredini, Sandro Ferrarese, Claudio Corazzari, Cesare Beghi, Annamaria Buschini
    Bioscience Reports.2021;[Epub]     CrossRef
  • The Role of Serum Calcium Levels in Pediatric Dyslipidemia: Are There Any?
    Yaguang Peng, Lixin Hu, Xiaolu Nie, Siyu Cai, Ruohua Yan, Yali Liu, Yanying Cai, Wenqi Song, Xiaoxia Peng
    Frontiers in Pediatrics.2021;[Epub]     CrossRef
  • The impact of serum 25-hydroxyvitamin D, calcium, and parathyroid hormone levels on the risk of coronary artery disease in patients with diabetes: a Mendelian randomization study
    Songzan Chen, Fangkun Yang, Tian Xu, Yao Wang, Kaijie Zhang, Guosheng Fu, Wenbin Zhang
    Nutrition Journal.2021;[Epub]     CrossRef
  • Temporal Relationship Between Changes in Serum Calcium and Hypercholesteremia and Its Impact on Future Brachial-Ankle Pulse Wave Velocity Levels
    Xing Meng, Tianshu Han, Wenbo Jiang, Fengli Dong, Hongxue Sun, Wei Wei, Yageng Yan
    Frontiers in Nutrition.2021;[Epub]     CrossRef
  • The Evidence and Controversy Between Dietary Calcium Intake and Calcium Supplementation and the Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Cohort Studies and Randomized Controlled Trials
    Chao Yang, Xiangling Shi, Hui Xia, Xian Yang, Hechun Liu, Da Pan, Guiju Sun
    Journal of the American College of Nutrition.2020; 39(4): 352.     CrossRef
  • Association between the cumulative exposure to bisphosphonates and hospitalization for atherosclerotic cardiovascular events: A population-based study
    Manuela Casula, Elena Olmastroni, Federica Galimberti, Elena Tragni, Giovanni Corrao, Lorenza Scotti, Alberico L. Catapano
    Atherosclerosis.2020; 301: 1.     CrossRef
  • Calcium and/or Vitamin D Supplementation for the Prevention of Fragility Fractures: Who Needs It?
    Ian R Reid, Mark J Bolland
    Nutrients.2020; 12(4): 1011.     CrossRef
  • Oxalates, urinary stones and risk of cardiovascular diseases
    Ahmed Arafa, Ehab S. Eshak, Hiroyasu Iso
    Medical Hypotheses.2020; 137: 109570.     CrossRef
  • A dual signal on-off fluorescent nanosensor for the simultaneous detection of copper and creatinine
    Resmi V. Nair, Parvathy Radhakrishna Pillai Suma, Ramapurath S. Jayasree
    Materials Science and Engineering: C.2020; 109: 110569.     CrossRef
  • Soy isoflavones interact with calcium and contribute to blood pressure homeostasis in women: a randomized, double-blind, placebo controlled trial
    Lee-Jane W. Lu, Nai-Wei Chen, Fatima Nayeem, Manubai Nagamani, Karl E. Anderson
    European Journal of Nutrition.2020; 59(6): 2369.     CrossRef
  • Associations between diet and mental health using the 12-item General Health Questionnaire: cross-sectional and prospective analyses from the Japan Multi-Institutional Collaborative Cohort Study
    Naoki Choda, Kenji Wakai, Mariko Naito, Nahomi Imaeda, Chiho Goto, Kenta Maruyama, Yuka Kadomatsu, Mineko Tsukamoto, Tae Sasakabe, Yoko Kubo, Rieko Okada, Sayo Kawai, Takashi Tamura, Asahi Hishida, Kenji Takeuchi, Atsuyoshi Mori, Nobuyuki Hamajima
    Nutrition Journal.2020;[Epub]     CrossRef
  • Vitamin D supplementation and incident preeclampsia: A systematic review and meta-analysis of randomized clinical trials
    Silvia Fogacci, Federica Fogacci, Maciej Banach, Erin D. Michos, Adrian V. Hernandez, Gregory Y.H. Lip, Michael J. Blaha, Peter P. Toth, Claudio Borghi, Arrigo F.G. Cicero
    Clinical Nutrition.2020; 39(6): 1742.     CrossRef
  • Establishing Benefit from Vitamin D Supplementation — Adherence to Defined Criteria and Targeting of High-Risk Groups Essential?
    Siobhán McGettigan, P. Mulkerrin, P.M. O'Shea, S.T. O'Keeffe, E.C. Mulkerrin
    The Journal of nutrition, health and aging.2020; 24(8): 827.     CrossRef
  • Nutritional Quality and Health Effects of Low Environmental Impact Diets: The “Seguimiento Universidad de Navarra” (SUN) Cohort
    Ujué Fresán, Winston J. Craig, Miguel A. Martínez-González, Maira Bes-Rastrollo
    Nutrients.2020; 12(8): 2385.     CrossRef
  • Beyond Fish Oil Supplementation: The Effects of Alternative Plant Sources of Omega-3 Polyunsaturated Fatty Acids upon Lipid Indexes and Cardiometabolic Biomarkers—An Overview
    Heitor O. Santos, James C. Price, Allain A. Bueno
    Nutrients.2020; 12(10): 3159.     CrossRef
  • Oxidative stress by Ca2+ overload is critical for phosphate-induced vascular calcification
    Nhung Thi Nguyen, Tuyet Thi Nguyen, Dat Da Ly, Jing-Bo Xia, Xu-Feng Qi, In-Kyu Lee, Seung-Kuy Cha, Kyu-Sang Park
    American Journal of Physiology-Heart and Circulatory Physiology.2020; 319(6): H1302.     CrossRef
  • A Naringin- and Icariin-Contained Herbal Formula, Gushukang, Ameliorated Aged Osteoporosis of Aged Mice with High Calcium Intake
    Xiao-Li Li, Fei Xu, Fu-Hui Lin, Lian-Zhong Ai, Yong-Jian Zhao, Xiao-Lei Bi, Li Sui, Yan Zhang
    The American Journal of Chinese Medicine.2020; 48(07): 1671.     CrossRef
  • Gushukang exerts osteopreserve effects by regulating vitamin D and calcium metabolism in ovariectomized mice
    Xiao-Li Li, Liang Wang, Xiao-Lei Bi, Bing-Bing Chen, Yan Zhang
    Journal of Bone and Mineral Metabolism.2019; 37(2): 224.     CrossRef
  • Genetic predisposition to increased serum calcium, bone mineral density, and fracture risk in individuals with normal calcium levels: mendelian randomisation study
    Agustin Cerani, Sirui Zhou, Vincenzo Forgetta, John A Morris, Katerina Trajanoska, Fernando Rivadeneira, Susanna C Larsson, Karl Michaëlsson, J Brent Richards
    BMJ.2019; : l4410.     CrossRef
  • Protective Effects of Phenylpropanoids and Phenylpropanoid-rich Essential Oils on the Cardiovascular System
    Jorge M. Alves-Silva, Mónica Zuzarte, Carla Marques, Henrique Girão, Lígia Salgueiro
    Mini-Reviews in Medicinal Chemistry.2019; 19(17): 1459.     CrossRef
  • Borderline high serum calcium levels are associated with arterial stiffness and 10‐year cardiovascular disease risk determined by Framingham risk score
    Byoungjin Park, Yong‐Jae Lee
    The Journal of Clinical Hypertension.2019; 21(5): 668.     CrossRef
  • Effects of IGF-1 on the Cardiovascular System
    Milan Obradovic, Sonja Zafirovic, Sanja Soskic, Julijana Stanimirovic, Andreja Trpkovic, Danimir Jevremovic, Esma R. Isenovic
    Current Pharmaceutical Design.2019; 25(35): 3715.     CrossRef
  • Associations between serum calcium, 25(OH)D level and bone mineral density in older adults
    Minbo Liu, Xiaocong Yao, Zhongxin Zhu
    Journal of Orthopaedic Surgery and Research.2019;[Epub]     CrossRef
  • Controversies in medicine: the role of calcium and vitamin D supplements in adults
    Ian R Reid, Mark J Bolland
    Medical Journal of Australia.2019; 211(10): 468.     CrossRef
  • Structural insight into TRPV5 channel function and modulation
    Shangyu Dang, Mark K. van Goor, Daniel Asarnow, YongQiang Wang, David Julius, Yifan Cheng, Jenny van der Wijst
    Proceedings of the National Academy of Sciences.2019; 116(18): 8869.     CrossRef
  • Serum calcium levels independently predict in-hospital mortality in patients with acute myocardial infarction
    A. Shiyovich, Y. Plakht, H. Gilutz
    Nutrition, Metabolism and Cardiovascular Diseases.2018; 28(5): 510.     CrossRef
  • Primary Bone Marrow B-Cell Lymphoma Undetected by Multiple Imaging Modalities That Initially Presented with Hypercalcemia
    Jin Sae Yoo, Juwon Kim, Hyeong Ju Kwon, Jung Soo Lim
    Case Reports in Endocrinology.2018; 2018: 1.     CrossRef
  • Dietary Micronutrient and Mineral Intake in the Mediterranean Healthy Eating, Ageing, and Lifestyle (MEAL) Study
    Dora Castiglione, Armando Platania, Alessandra Conti, Mariagiovanna Falla, Maurizio D’Urso, Marina Marranzano
    Antioxidants.2018; 7(7): 79.     CrossRef
  • Calcium fluxes at the bone/plasma interface: Acute effects of parathyroid hormone (PTH) and targeted deletion of PTH/PTH-related peptide (PTHrP) receptor in the osteocytes
    Christopher Dedic, Tin Shing Hung, Alan M. Shipley, Akira Maeda, Thomas Gardella, Andrew L. Miller, Paola Divieti Pajevic, Joseph G. Kunkel, Alessandro Rubinacci
    Bone.2018; 116: 135.     CrossRef
  • Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism
    Jung Soo Lim, Namki Hong, Sungha Park, Sung Il Park, Young Taik Oh, Min Heui Yu, Pil Yong Lim, Yumie Rhee
    Endocrinology and Metabolism.2018; 33(4): 485.     CrossRef
Close layer
Obesity and Metabolism
Sarcopenia and Sarcopenic Obesity
Kyung Mook Choi
Endocrinol Metab. 2013;28(2):86-89.   Published online June 18, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.2.86
  • 4,998 View
  • 59 Download
  • 62 Web of Science
  • 67 Crossref
AbstractAbstract PDFPubReader   

The aging process is associated with progressive loss of muscle mass and strength, as well as decline in physical functioning. Although consensus diagnosis has not been reached, sarcopenia is increasingly defined by both loss of muscle mass and loss of muscle function or strength. The cause of sarcopenia is suggested as multifactorial, including hormonal changes, inflammatory pathway activation, fatty infiltration, poor nutrition, and decreased physical activity. Sarcopenia is often associated with visceral obesity. Sarcopenic obesity in the elderly impacts metabolic complications and represents a major public health challenge in a rapidly aging society. Further research about sarcopenia and sarcopenic obesity may be needed to confront the influence of aging society in Korea.

Citations

Citations to this article as recorded by  
  • Aging, Physical Exercise, Telomeres, and Sarcopenia: A Narrative Review
    David Hernández-Álvarez, Juana Rosado-Pérez, Graciela Gavia-García, Taide Laurita Arista-Ugalde, Itzen Aguiñiga-Sánchez, Edelmiro Santiago-Osorio, Víctor Manuel Mendoza-Núñez
    Biomedicines.2023; 11(2): 598.     CrossRef
  • Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
    Min Jeong Park, Kyung Mook Choi
    Metabolism.2023; 144: 155577.     CrossRef
  • Sarcopenia in chronic kidney disease: from bench to bedside
    Da Woon Kim, Sang Heon Song
    The Korean Journal of Internal Medicine.2023; 38(3): 303.     CrossRef
  • The serum creatinine to cystatin C to waist circumference ratios predicts risk for type 2 diabetes: A Chinese cohort study
    Yinfei Chen, Weiheng Wen, Zhiliang Mai, Ming Wang, Hong Chen, Jia Sun
    Journal of Diabetes.2023; 15(10): 808.     CrossRef
  • Sarcopenic obesity in children
    A. N. Zav’yalova, M. E. Troshkina, L. A. Shcherbak, V. P. Novikova
    Experimental and Clinical Gastroenterology.2023; 1(1): 134.     CrossRef
  • The Effects of Obesity on the Inflammatory, Cardiovascular, and Neurobiological Responses to Exercise in Older Adults
    Brandon G. Fico, Arun Maharaj, Gabriel S. Pena, Chun-Jung Huang
    Biology.2023; 12(6): 865.     CrossRef
  • Correlation of Sarcopenic Obesity on Various Cardiometabolic Risk Factors and Fracture Risk in Mid-Aged Korean Women
    Eun Hee Yu, Hyun Joo Lee, Hyeon Jin Kim, In Hye Kim, Jong Kil Joo, Yong Jin Na
    Journal of Menopausal Medicine.2023; 29(2): 58.     CrossRef
  • Sarkopenik Obezite ile Mücadelede Egzersiz ve Beslenme Stratejileri
    Ayşe ŞİMŞEK, Musa GÜNEŞ, Büşra DEMİRER
    İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi.2023; (20): 677.     CrossRef
  • How to Diagnose Sarcopenic Obesity in Candidates for Bariatric Surgery?
    Gabriela B. Bacelar, Estevão F. Sampaio, Wagno Alcântara, João Gabriel Lustoza, Cláudia Daltro, Carla Daltro
    Bariatric Surgical Practice and Patient Care.2022; 17(4): 237.     CrossRef
  • Usefulness of Muscle Ultrasound to Study Sarcopenic Obesity: A Pilot Case-Control Study
    Andreu Simó-Servat, Montse Ibarra, Mireia Libran, Silvia Rodríguez, Verónica Perea, Carmen Quirós, Aida Orois, Noelia Pérez, Rafael Simó, Maria-José Barahona
    Journal of Clinical Medicine.2022; 11(10): 2886.     CrossRef
  • Association between body shape index and risk of mortality in the United States
    Heysoo Lee, Hye Soo Chung, Yoon Jung Kim, Min Kyu Choi, Yong Kyun Roh, Wankyo Chung, Jae Myung Yu, Chang-Myung Oh, Shinje Moon
    Scientific Reports.2022;[Epub]     CrossRef
  • Associations between Weight-Adjusted Waist Index and Abdominal Fat and Muscle Mass: Multi-Ethnic Study of Atherosclerosis
    Ji Yoon Kim, Jimi Choi, Chantal A. Vella, Michael H. Criqui, Matthew A. Allison, Nam Hoon Kim
    Diabetes & Metabolism Journal.2022; 46(5): 747.     CrossRef
  • Prevalence of Sarcopenic Obesity in Various Comorbidities, Diagnostic Markers, and Therapeutic Approaches: A Review
    Mangalam Kumari, Archana Khanna
    Annals of Geriatric Medicine and Research.2022; 26(4): 296.     CrossRef
  • Sarcopenic obesity: research advances in pathogenesis and diagnostic criteria
    Wen-qing Xie, Ge-lei Xiao, Yi-bin Fan, Miao He, Shan Lv, Yu-sheng Li
    Aging Clinical and Experimental Research.2021; 33(2): 247.     CrossRef
  • Effect of Sarcopenia and Body Shape on Cardiovascular Disease According to Obesity Phenotypes
    Hyun-Woong Cho, Wankyo Chung, Shinje Moon, Ohk-Hyun Ryu, Min Kyung Kim, Jun Goo Kang
    Diabetes & Metabolism Journal.2021; 45(2): 209.     CrossRef
  • Prevalence, diagnostic criteria, and factors associated with sarcopenic obesity in older adults from a low middle income country: A systematic review
    Maria Sortênia Alves Guimarães, Carolina Araújo dos Santos, Joice da Silva Castro, Leidjaira Lopes Juvanhol, Fabiane Aparecida Canaan Rezende, Karina Oliveira Martinho, Andréia Queiroz Ribeiro
    Clinical Nutrition ESPEN.2021; 41: 94.     CrossRef
  • Engagement in Muscle-Strengthening Activities Lowers Sarcopenia Risk in Older Adults Already Adhering to the Aerobic Physical Activity Guidelines
    Jort Veen, Diego Montiel-Rojas, Andreas Nilsson, Fawzi Kadi
    International Journal of Environmental Research and Public Health.2021; 18(3): 989.     CrossRef
  • Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults
    Da Ae Kim, So Jeong Park, Jin Young Lee, Jeoung Hee Kim, Seungjoo Lee, Eunju Lee, Il-Young Jang, Hee-Won Jung, Jin Hoon Park, Beom-Jun Kim
    Endocrinology and Metabolism.2021; 36(2): 455.     CrossRef
  • The Critical Role of Oxidative Stress in Sarcopenic Obesity
    Andrea Gonzalez, Felipe Simon, Oscar Achiardi, Cristian Vilos, Daniel Cabrera, Claudio Cabello-Verrugio, Vladimir Jakovljevic
    Oxidative Medicine and Cellular Longevity.2021; 2021: 1.     CrossRef
  • Evaluation of the association between decreased skeletal muscle mass and extubation failure after long-term mechanical ventilation
    Hye Young Woo, Seung-Young Oh, Hannah Lee, Ho Geol Ryu
    Clinical Nutrition.2020; 39(9): 2764.     CrossRef
  • Association Between Sarcopenic Obesity and Metabolic Syndrome in Adults: A Systematic Review and Meta-Analysis
    Dima Khadra, Leila Itani, Yomna Chebaro, May Obeid, Miryam Jaber, Reham Ghanem, Agnes Ayton, Dima Kreidieh, Dana E. Masri, Akira Kimura, Hana Tannir, Marwan El Ghoch
    Current Cardiology Reviews.2020; 16(2): 153.     CrossRef
  • Sarcopenic obesity in ageing: cardiovascular outcomes and mortality
    Janice L. Atkins, S. Goya Wannamathee
    British Journal of Nutrition.2020; 124(10): 1102.     CrossRef
  • Inflammation and metabolism: the role of adiposity in sarcopenic obesity
    G. M. Lynch, C. H. Murphy, E. de Marco Castro, H. M. Roche
    Proceedings of the Nutrition Society.2020; 79(4): 435.     CrossRef
  • Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
    Mina Wang, Yan Tan, Yifan Shi, Xu Wang, Zehuan Liao, Peng Wei
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Relationship between Decreased Estimated Glomerular Filtration Rate and Sarcopenic Obesity among Postmenopausal Women: Korea National Health and Nutrition Examination Survey (2008–2011)
    Changbin Hong, Jae Yong Baek, Ji Won Lee, Ji Hoon Lee, Kayoung Lee, Tae-jin Park, Jinseung Kim
    Korean Journal of Family Medicine.2020; 41(5): 332.     CrossRef
  • Effect of body shape on the development of cardiovascular disease in individuals with metabolically healthy obesity
    Chang-Myung Oh, Jung Hwan Park, Hye Soo Chung, Jae Myung Yu, Wankyo Chung, Jun Goo Kang, Shinje Moon
    Medicine.2020; 99(38): e22036.     CrossRef
  • Sarcopenia Associated with Chronic Obstructive Pulmonary Disease
    Sang Hun Kim, Myung Jun Shin, Yong Beom Shin, Ki Uk Kim
    Journal of Bone Metabolism.2019; 26(2): 65.     CrossRef
  • Sarcopenia and Sarcopenic Obesity as Novel Risk Factors for Gastric Carcinogenesis: A Health Checkup Cohort Study
    Young Min Kim, Jie-Hyun Kim, Su Jung Baik, Jaeyoung Chun, Young Hoon Youn, Hyojin Park
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • Association between skeletal muscle attenuation and gastroesophageal reflux disease: A health check-up cohort study
    Young Min Kim, Jie-Hyun Kim, Su Jung Baik, Da Hyun Jung, Jae Jun Park, Young Hoon Youn, Hyojin Park
    Scientific Reports.2019;[Epub]     CrossRef
  • A High Serum Cortisol/DHEA-S Ratio Is a Risk Factor for Sarcopenia in Elderly Diabetic Patients
    Ikumi Yanagita, Yuya Fujihara, Yuichi Kitajima, Misuzu Tajima, Masanao Honda, Tomoko Kawajiri, Terumi Eda, Kazue Yonemura, Noriko Yamaguchi, Hideko Asakawa, Yukiko Nei, Yumi Kayashima, Mihoko Yoshimoto, Mayumi Harada, Yuhei Araki, Shoji Yoshimoto, Eiji Ai
    Journal of the Endocrine Society.2019; 3(4): 801.     CrossRef
  • SARCOPENIA AND SEVERITY OF NON-ALCOHOLIC FATTY LIVER DISEASE
    Josilda Ferreira CRUZ, Yasmim Anayr Costa FERRARI, Carla Perez MACHADO, Nathalia Nascimento SANTANA, Allan Victor Hora MOTA, Sonia Oliveira LIMA
    Arquivos de Gastroenterologia.2019; 56(4): 357.     CrossRef
  • Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis
    Dima Khadra, Leila Itani, Hana Tannir, Dima Kreidieh, Dana El Masri, Marwan El Ghoch
    World Journal of Diabetes.2019; 10(5): 311.     CrossRef
  • Prognostic networks for unraveling the biological mechanisms of Sarcopenia
    Ana Cernea, Juan Luis Fernández-Martínez, Enrique Juan de Andrés-Galiana, Zulima Fernández-Muñiz, Juan Carlos Bermejo-Millo, Laura González-Blanco, Juan José Solano, Pedro Abizanda, Ana Coto-Montes, Beatriz Caballero
    Mechanisms of Ageing and Development.2019; 182: 111129.     CrossRef
  • Malnutrition as a Complication of Bariatric Surgery – A Clear and Present Danger?
    Jessica Lange, Alfred Königsrainer
    Visceral Medicine.2019; 35(5): 305.     CrossRef
  • 変形性膝関節症とサルコペニア肥満

    Orthopedics & Traumatology.2018; 67(2): 350.     CrossRef
  • Sarcopenic obesity
    Stergios A. Polyzos, Andrew N. Margioris
    Hormones.2018; 17(3): 321.     CrossRef
  • Is sarcopenia and sarcopenic obesity associated with clinical and pathological outcomes in patients undergoing radical nephroureterectomy?
    Neil J. Kocher, Syed Jafri, Samyuktha Balabhadra, Erik Lehman, Jacob Gardner, Kanupriya Vijay, Nabeel Sarwani, Jay D. Raman
    Urologic Oncology: Seminars and Original Investigations.2018; 36(4): 156.e17.     CrossRef
  • The association of low muscle mass with soluble receptor for advanced glycation end products (sRAGE): The Korean Sarcopenic Obesity Study (KSOS)
    Tae Nyun Kim, Man Sik Park, Eun Joo Lee, Hye Soo Chung, Hye Jin Yoo, Hyun Joo Kang, Wook Song, Sei Hyun Baik, Kyung Mook Choi
    Diabetes/Metabolism Research and Reviews.2018;[Epub]     CrossRef
  • Lower-limb muscle strength according to bodyweight and muscle mass among middle age patients with type 2 diabetes without diabetic neuropathy
    Fuminari Asada, Takuo Nomura, Mitsuo Tagami, Masashi Kubota, Makoto Ohashi, Makoto Nomura
    Journal of Physical Therapy Science.2017; 29(7): 1181.     CrossRef
  • Association between Sarcopenic Obesity and Metabolic Syndrome in Postmenopausal Women: A Cross-sectional Study Based on the Korean National Health and Nutritional Examination Surveys from 2008 to 2011
    Sun-Young Kang, Gyeong Eun Lim, Yang Keun Kim, Hye Won Kim, Kayoung Lee, Tae-Jin Park, Jinseung Kim
    Journal of Bone Metabolism.2017; 24(1): 9.     CrossRef
  • Changes in Body Composition According to Age and Sex among Young Non-Diabetic Korean Adults: the Kangbuk Samsung Health Study
    Seul-Ki Kim, Yu-Hyun Kwon, Jung Hwan Cho, Da Young Lee, Se Eun Park, Hyung-Geun Oh, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
    Endocrinology and Metabolism.2017; 32(4): 442.     CrossRef
  • Health-related quality of life and activity limitation in an elderly Korean population with sarcopenia: The Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV-2, 3), 2008–2009
    T.H. Kim, S.-H. Kim, J. Kim, H.-J. Hwang
    European Geriatric Medicine.2017; 8(4): 360.     CrossRef
  • Rheumatoid Cachexia, a Metabolic Rheumatoid Arthritis Disorder: Pathophysiological Mechanisms, Diagnostic Tools and Current Therapeutic Strategy
    Imad Ghozlani
    Endocrinology&Metabolism International Journal.2017;[Epub]     CrossRef
  • Decreased muscle mass in Korean subjects with intracranial arterial stenosis: The Kangbuk Samsung Health Study
    Ho-Jung Jung, Hwanseok Jung, Taeyoung Lee, Jongho Kim, Jongsin Park, Hacsoo Kim, Junghwan Cho, Won-Young Lee, Sung-Woo Park, Eun-Jung Rhee, Hyung-Geun Oh
    Atherosclerosis.2017; 256: 89.     CrossRef
  • Lower Jump Power Rather Than Muscle Mass Itself is Associated with Vertebral Fracture in Community-Dwelling Elderly Korean Women
    Eun Young Lee, Su Jin Lee, Kyoung Min Kim, Da Hea Seo, Seung Won Lee, Han Sol Choi, Hyeon Chang Kim, Yoosik Youm, Chang Oh Kim, Yumie Rhee
    Calcified Tissue International.2017; 100(6): 585.     CrossRef
  • Effects of combination of change in visceral fat and thigh muscle mass on the development of type 2 diabetes
    Seung Jin Han, Soo-Kyung Kim, Wilfred Y. Fujimoto, Steven E. Kahn, Donna L. Leonetti, Edward J. Boyko
    Diabetes Research and Clinical Practice.2017; 134: 131.     CrossRef
  • Comparisons of three different methods for defining sarcopenia: An aspect of cardiometabolic risk
    Tae Nyun Kim, Man Sik Park, Eun Joo Lee, Hye Soo Chung, Hye Jin Yoo, Hyun Joo Kang, Wook Song, Sei Hyun Baik, Kyung Mook Choi
    Scientific Reports.2017;[Epub]     CrossRef
  • Association of metabolic syndrome and 25‐hydroxyvitamin D with cognitive impairment among elderly Koreans
    Eun Young Lee, Su Jin Lee, Kyoung Min Kim, Young Mi Yun, Bo Mi Song, Jong Eun Kim, Hyeon Chang Kim, Yumie Rhee, Yoosik Youm, Chang Oh Kim
    Geriatrics & Gerontology International.2017; 17(7): 1069.     CrossRef
  • Sarcopenia and sarcopenic obesity in patients with complex abdominal wall hernias
    John M. Rinaldi, Abby K. Geletzke, Brett E. Phillips, Jamie Miller, Thomas M. Dykes, David I. Soybel
    The American Journal of Surgery.2016; 212(5): 903.     CrossRef
  • Bariatric Surgery Outcomes in Sarcopenic Obesity
    Diego Mastino, Maud Robert, Cecile Betry, Martine Laville, Christian Gouillat, Emmanuel Disse
    Obesity Surgery.2016; 26(10): 2355.     CrossRef
  • Sarcopenia in Orthopedic Surgery
    Steven L. Bokshan, J. Mason DePasse, Alan H. Daniels
    Orthopedics.2016;[Epub]     CrossRef
  • Sarcopenia and Hearing Loss in Older Koreans: Findings from the Korea National Health and Nutrition Examination Survey (KNHANES) 2010
    Jieun Lee, Kyungdo Han, Jae Jun Song, Gi Jung Im, Sung Won Chae, Stephen E Alway
    PLOS ONE.2016; 11(3): e0150281.     CrossRef
  • Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia
    Kyoung Min Kim, Hak Chul Jang, Soo Lim
    The Korean Journal of Internal Medicine.2016; 31(4): 643.     CrossRef
  • Newly Developed Sarcopenia as a Prognostic Factor for Survival in Patients who Underwent Liver Transplantation
    Ja Young Jeon, Hee-Jung Wang, So Young Ock, Weiguang Xu, Jung-Dong Lee, Jei Hee Lee, Hae Jin Kim, Dae Jung Kim, Kwan Woo Lee, Seung Jin Han, Erica Villa
    PLOS ONE.2015; 10(11): e0143966.     CrossRef
  • The effect of sarcopenic obesity on cardiovascular disease and all-cause mortality in older people
    Janice L Atkins, S Goya Wannamethee
    Reviews in Clinical Gerontology.2015; 25(2): 86.     CrossRef
  • Low muscle mass is associated with metabolic syndrome only in nonobese young adults: the Korea National Health and Nutrition Examination Survey 2008-2010
    Byung Chul Kim, Mee Kyoung Kim, Kyungdo Han, Sae-Young Lee, Seung-Hwan Lee, Seung-Hyun Ko, Hyuk-Sang Kwon, Anwar T. Merchant, Hyeon Woo Yim, Won-Chul Lee, Yong Gyu Park, Yong-Moon Park
    Nutrition Research.2015; 35(12): 1070.     CrossRef
  • Identifying subgroups of obesity using the product of triglycerides and glucose: the Korea National Health and Nutrition Examination Survey, 2008–2010
    Seung‐Hwan Lee, Kyungdo Han, Hae Kyung Yang, Mee Kyoung Kim, Kun‐Ho Yoon, Hyuk‐Sang Kwon, Yong‐Moon Park
    Clinical Endocrinology.2015; 82(2): 213.     CrossRef
  • Effect of beta-hydroxy-beta-methylbutyrate supplementation on muscle loss in older adults: A systematic review and meta-analysis
    Hongmei Wu, Yang Xia, Jin Jiang, Huanmin Du, Xiaoyan Guo, Xing Liu, Chunlei Li, Guowei Huang, Kaijun Niu
    Archives of Gerontology and Geriatrics.2015; 61(2): 168.     CrossRef
  • Muscle loss and obesity: the health implications of sarcopenia and sarcopenic obesity
    S. Goya Wannamethee, Janice L. Atkins
    Proceedings of the Nutrition Society.2015; 74(4): 405.     CrossRef
  • Subclinical vascular inflammation in subjects with normal weight obesity and its association with body Fat: an 18 F-FDG-PET/CT study
    Shinae Kang, Chanhee Kyung, Jong Suk Park, Sohee Kim, Seung-Pyo Lee, Min Kyung Kim, Hye Kyung Kim, Kyung Rae Kim, Tae Joo Jeon, Chul Woo Ahn
    Cardiovascular Diabetology.2014;[Epub]     CrossRef
  • Using mobile phones in healthcare management for the elderly
    Hun-Sung Kim, Kye-Hwa Lee, Hyunah Kim, Ju Han Kim
    Maturitas.2014; 79(4): 381.     CrossRef
  • Sarcopenia as a Determinant of Blood Pressure in Older Koreans: Findings from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2008–2010
    Kyungdo Han, Yu-Mi Park, Hyuk-Sang Kwon, Seung-Hyun Ko, Seung-Hwan Lee, Hyeon Woo Yim, Won-Chul Lee, Yong Gyu Park, Mee Kyoung Kim, Yong-Moon Park, Yan Li
    PLoS ONE.2014; 9(1): e86902.     CrossRef
  • An Overview of the Identification and Management of the Metabolic Syndrome in Chiropractic Practice
    David R. Seaman, Adam D. Palombo
    Journal of Chiropractic Medicine.2014; 13(3): 210.     CrossRef
  • Sarcopenia and Neurosurgery
    Seung Won Park
    Journal of Korean Neurosurgical Society.2014; 56(2): 79.     CrossRef
  • Growing healthy muscles to optimise metabolic health into adult life
    S. A. Bayol, C. R. Bruce, G. D. Wadley
    Journal of Developmental Origins of Health and Disease.2014; 5(6): 420.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • Variation in Serum Creatinine Level Is Correlated to Risk of Type 2 Diabetes
    Jun Sung Moon, Ji Eun Lee, Ji Sung Yoon
    Endocrinology and Metabolism.2013; 28(3): 207.     CrossRef
Close layer
Namgok Lecture 2019
Obesity and Metabolism
Impact of Skeletal Muscle Mass on Metabolic Health
Gyuri Kim, Jae Hyeon Kim
Endocrinol Metab. 2020;35(1):1-6.   Published online March 19, 2020
DOI: https://doi.org/10.3803/EnM.2020.35.1.1
  • 10,247 View
  • 282 Download
  • 62 Web of Science
  • 65 Crossref
AbstractAbstract PDFPubReader   ePub   

Skeletal muscle is regarded as an endocrine and paracrine organ. Muscle-derived secretory proteins, referred to as myokines, mediate interactions between skeletal muscle mass and other organs such as the liver, adipose tissue, pancreas, bone, and the cardiovascular system. As individuals age, reduced levels of physical activity and sarcopenia (loss of skeletal muscle mass and strength) are associated with physical frailty and disability. Recently, several studies have suggested that the loss of skeletal muscle mass may contribute to metabolic disease. Therefore, herein, we focus on the relationships between skeletal muscle mass and metabolic diseases, including metabolic syndrome and non-alcoholic fatty liver disease.

Citations

Citations to this article as recorded by  
  • Advances in the treatment of functional male hypogonadism
    Giovanni Corona, Giulia Rastrelli, Clotilde Sparano, Linda Vignozzi, Alessandra Sforza, Mario Maggi
    Expert Review of Endocrinology & Metabolism.2024; 19(2): 163.     CrossRef
  • Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors
    Min Wang, Yang Ou, Xiang-Lian Yuan, Xiu-Fang Zhu, Ben Niu, Zhuang Kang, Bing Zhang, Anwar Ahmed, Guo-Qiang Xing, Heng Su
    World Journal of Diabetes.2024; 15(1): 53.     CrossRef
  • The Vicious Cycle of Type 2 Diabetes Mellitus and Skeletal Muscle Atrophy: Clinical, Biochemical, and Nutritional Bases
    Jose M. Lopez-Pedrosa, Maria Camprubi-Robles, German Guzman-Rolo, Andres Lopez-Gonzalez, Jose Manuel Garcia-Almeida, Alejandro Sanz-Paris, Ricardo Rueda
    Nutrients.2024; 16(1): 172.     CrossRef
  • FGF21 Induces Skeletal Muscle Atrophy and Increases Amino Acids in Female Mice: A Potential Role for Glucocorticoids
    Karlton R Larson, Devi Jayakrishnan, Karla A Soto Sauza, Michael L Goodson, Aki T Chaffin, Arik Davidyan, Suraj Pathak, Yanbin Fang, Diego Gonzalez Magaña, Benjamin F Miller, Karen K Ryan
    Endocrinology.2024;[Epub]     CrossRef
  • Prevalence of adiposity-based chronic disease and its association with anthropometric and clinical indices: a cross-sectional study
    Luis E González-Salazar, Aurora E Serralde-Zúñiga, Adriana Flores-López, Juan P Díaz-Sánchez, Isabel Medina-Vera, Edgar Pichardo-Ontiveros, Rocío Guizar-Heredia, Karla G Hernández-Gómez, Ana Vigil-Martínez, Liliana Arteaga-Sánchez, Azalia Avila-Nava, Nata
    British Journal of Nutrition.2023; 130(1): 93.     CrossRef
  • Skeletal Muscle Myokine Expression in Critical Illness, Association With Outcome and Impact of Therapeutic Interventions
    Ilse Vanhorebeek, Jan Gunst, Michaël P Casaer, Inge Derese, Sarah Derde, Lies Pauwels, Johan Segers, Greet Hermans, Rik Gosselink, Greet Van den Berghe
    Journal of the Endocrine Society.2023;[Epub]     CrossRef
  • Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies
    Norsham Juliana, Liyana Azmi, Nadia Mohd Effendy, Nur Islami Mohd Fahmi Teng, Izuddin Fahmy Abu, Nur Nabilah Abu Bakar, Sahar Azmani, Noor Anisah Abu Yazit, Suhaini Kadiman, Srijit Das
    Nutrients.2023; 15(3): 734.     CrossRef
  • Molecular mechanisms of post‐burn muscle wasting and the therapeutic potential of physical exercise
    Dorien Dombrecht, Ulrike Van Daele, Birgit Van Asbroeck, David Schieffelers, Pieter‐Jan Guns, Nick Gebruers, Jill Meirte, Eric van Breda
    Journal of Cachexia, Sarcopenia and Muscle.2023; 14(2): 758.     CrossRef
  • Metabolic Impact of Frailty Changes Diabetes Trajectory
    Alan J. Sinclair, Ahmed H. Abdelhafiz
    Metabolites.2023; 13(2): 295.     CrossRef
  • From Single- to Multi-organ-on-a-Chip System for Studying Metabolic Diseases
    Minjeong Jang, Hong Nam Kim
    BioChip Journal.2023; 17(2): 133.     CrossRef
  • INFLUENCE OF SARCOPENIA ON THE COURSE AND PROGNOSIS IN PATIENTS WITH CHRONIC HEART FAILURE
    Gulyaev N.I., Adamov A.A., Akhmetshin I.M.
    "Medical & pharmaceutical journal "Pulse".2023; : 124.     CrossRef
  • Frailty and the Interactions between Skeletal Muscle, Bone, and Adipose Tissue-Impact on Cardiovascular Disease and Possible Therapeutic Measures
    María Elena Soto, Israel Pérez-Torres, María Esther Rubio-Ruiz, Agustina Cano-Martínez, Linaloe Manzano-Pech, Verónica Guarner-Lans
    International Journal of Molecular Sciences.2023; 24(5): 4534.     CrossRef
  • Sarcoplasmic Reticulum Ca2+ Buffer Proteins: A Focus on the Yet-To-Be-Explored Role of Sarcalumenin in Skeletal Muscle Health and Disease
    Elena Conte, Giorgia Dinoi, Paola Imbrici, Annamaria De Luca, Antonella Liantonio
    Cells.2023; 12(5): 715.     CrossRef
  • Antarctic krill extracts enhance muscle regeneration and muscle function via mammalian target of rapamycin regulation
    Seongmin Lee, Mi-Ock Baek, Sana Abdul Khaliq, Amna Parveen, Sun Yeou Kim, Jin-Hyoung Kim, Il-Chan Kim, Mee-Sup Yoon
    Journal of Functional Foods.2023; 103: 105483.     CrossRef
  • Pharmacological and physiological roles of adipokines and myokines in metabolic-related dementia
    Archana Arjunan, Juhyun Song
    Biomedicine & Pharmacotherapy.2023; 163: 114847.     CrossRef
  • PRMT5 links lipid metabolism to contractile function of skeletal muscles
    Kun Ho Kim, Zhihao Jia, Madigan Snyder, Jingjuan Chen, Jiamin Qiu, Stephanie N Oprescu, Xiyue Chen, Sabriya A Syed, Feng Yue, Bruno T Roseguini, Anthony N Imbalzano, Changdeng Hu, Shihuan Kuang
    EMBO reports.2023;[Epub]     CrossRef
  • “Biqi” Bayberry Extract Promotes Skeletal Muscle Fiber Type Remodeling by Increasing Fast Myofiber Formation via the Akt/FoxO1 Pathway in Mice
    Jinjie Li, Yi Li, Xiangying Suo, Jiangtao Li, Da Huang, Guangning Kou
    Foods.2023; 12(13): 2471.     CrossRef
  • Effects of high-intensity interval training (HIIT) on skeletal muscle atrophy, function, and myokine profile in diabetic myopathy
    Yeşim Özçatal, Fırat Akat, Yakup Tatar, Hakan Fıçıcılar, Bilge Serdaroğlu, Ferda Topal Çelikkan, Metin Baştuğ
    Cytokine.2023; 169: 156279.     CrossRef
  • Impaired proteostatic mechanisms other than decreased protein synthesis limit old skeletal muscle recovery after disuse atrophy
    Jordan D. Fuqua, Marcus M. Lawrence, Zachary R. Hettinger, Agnieszka K. Borowik, Parker L. Brecheen, Marcelina M. Szczygiel, Claire B. Abbott, Frederick F. Peelor, Amy L. Confides, Michael Kinter, Sue C. Bodine, Esther E. Dupont‐Versteegden, Benjamin F. M
    Journal of Cachexia, Sarcopenia and Muscle.2023; 14(5): 2076.     CrossRef
  • Body physique rating as a factor to identify at-risk Mexicans for Metabolic Syndrome
    Oscar Herrera-Fomperosa, Sergio K. Bustamante-Villagomez, Sarahí Vazquez-Álvarez, Gabriela Vázquez-Marroquín, Leonardo M. Porchia, Enrique Torres-Rasgado, Ricardo Pérez-Fuentes, M. Elba Gonzalez-Mejia
    Human Nutrition & Metabolism.2023; 33: 200206.     CrossRef
  • Sex differences in the association between dual‐energy x‐ray absorptiometry‐measured body composition and periodontitis
    Peijun Zhu, An Li, Qingqing Cai, Yuntao Chen, Yang Liu, Harriët Jager‐Wittenaar, Geerten‐Has E. Tjakkes, Shulan Xu
    Journal of Periodontology.2023;[Epub]     CrossRef
  • Association between Fractional Oxygen Extraction from Resting Quadriceps Muscle and Body Composition in Healthy Men
    Rodrigo Yáñez-Sepúlveda, Jorge Olivares-Arancibia, Guillermo Cortés-Roco, Aldo Vasquez-Bonilla, Matías Monsalves-Álvarez, Ildefonso Alvear-Órdenes, Marcelo Tuesta
    Journal of Functional Morphology and Kinesiology.2023; 8(4): 149.     CrossRef
  • Correlations between Mental Health, Physical Activity, and Body Composition in American College Students after the COVID-19 Pandemic Lockdown
    Luis Torres, Manuela C. Caciula, Alin S. Tomoiaga, Carmen Gugu-Gramatopol
    International Journal of Environmental Research and Public Health.2023; 20(22): 7045.     CrossRef
  • Association between total body muscle percentage and prevalence of non-alcoholic fatty liver disease in Korean adults findings from an 18-year follow-up: a prospective cohort study
    Byoung Chan Ahn, Chul Yong Park, Jung Hee Hong, Ki Ook Baek
    Journal of Yeungnam Medical Science.2023; 40(Suppl): S47.     CrossRef
  • The independent and joint associations among muscle strength, abdominal obesity and cardiometabolic variables among adults
    Tiago Rodrigues de Lima, David Alejandro González‐Chica, Xuemei Sui, Diego Augusto Santos Silva
    European Journal of Sport Science.2022; 22(7): 1122.     CrossRef
  • Mentale Gesundheit und physische Aktivität
    Wolfgang Laube
    Manuelle Medizin.2022; 60(1): 13.     CrossRef
  • A new paradigm in sarcopenia: Cognitive impairment caused by imbalanced myokine secretion and vascular dysfunction
    Danbi Jo, Gwangho Yoon, Oh Yoen Kim, Juhyun Song
    Biomedicine & Pharmacotherapy.2022; 147: 112636.     CrossRef
  • Sarcopenia Is a Cause and Consequence of Metabolic Dysregulation in Aging Humans: Effects of Gut Dysbiosis, Glucose Dysregulation, Diet and Lifestyle
    James W. Daily, Sunmin Park
    Cells.2022; 11(3): 338.     CrossRef
  • Leveraging deep phenotyping from health check-up cohort with 10,000 Korean individuals for phenome-wide association study of 136 traits
    Eun Kyung Choe, Manu Shivakumar, Anurag Verma, Shefali Setia Verma, Seung Ho Choi, Joo Sung Kim, Dokyoon Kim
    Scientific Reports.2022;[Epub]     CrossRef
  • Zika virus disrupts gene expression in human myoblasts and myotubes: Relationship with susceptibility to infection
    Ingo Riederer, Daniella Arêas Mendes-da-Cruz, Guilherme Cordenonsi da Fonseca, Mariela Natacha González, Otavio Brustolini, Cássia Rocha, Guilherme Loss, Joseane Biso de Carvalho, Mariane Talon Menezes, Lidiane Menezes Souza Raphael, Alexandra Gerber, Myr
    PLOS Neglected Tropical Diseases.2022; 16(2): e0010166.     CrossRef
  • Teil 1: Muskeldysfunktionen – mit Training gegen Schmerz
    Wolfgang Laube
    Manuelle Medizin.2022; 60(2): 84.     CrossRef
  • Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle
    Liyan Fan, David R. Sweet, Erica K. Fan, Domenick A. Prosdocimo, Annmarie Madera, Zhen Jiang, Roshan Padmanabhan, Saptarsi M. Haldar, Vinesh Vinayachandran, Mukesh K. Jain
    Journal of Biological Chemistry.2022; 298(6): 101926.     CrossRef
  • An Overview of the TRP-Oxidative Stress Axis in Metabolic Syndrome: Insights for Novel Therapeutic Approaches
    Mizael C. Araújo, Suzany H. S. Soczek, Jaqueline P. Pontes, Leonardo A. C. Marques, Gabriela S. Santos, Gisele Simão, Laryssa R. Bueno, Daniele Maria-Ferreira, Marcelo N. Muscará, Elizabeth S. Fernandes
    Cells.2022; 11(8): 1292.     CrossRef
  • Effects of a 10-Week Physical Activity Intervention on Asylum Seekers’ Physiological Health
    Matheus Guerra, Danilo Garcia, Maryam Kazemitabar, Erik Lindskär, Erica Schütz, Daniel Berglind
    Brain Sciences.2022; 12(7): 822.     CrossRef
  • Low muscle mass and mortality risk later in life: A 10-year follow-up study
    Cristina Camargo Pereira, Valéria Pagotto, Cesar de Oliveira, Erika Aparecida Silveira, Kiyoshi Sanada
    PLOS ONE.2022; 17(7): e0271579.     CrossRef
  • Independent and joint associations of weightlifting and aerobic activity with all-cause, cardiovascular disease and cancer mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
    Jessica Gorzelitz, Britton Trabert, Hormuzd A Katki, Steven C Moore, Eleanor L Watts, Charles E Matthews
    British Journal of Sports Medicine.2022; 56(22): 1277.     CrossRef
  • Handgrip Strength Cutoff Value Among Korean Adolescents with Metabolic Syndrome Components: Korean National Health and Nutrition Examination Survey Data 2014–2017
    Chang Hoon Lee, Jun Hyeok Lee, Yong Whi Jeong, Hong Koh, Yunkoo Kang
    Metabolic Syndrome and Related Disorders.2022; 20(10): 584.     CrossRef
  • Physical activity level, sitting time, and skeletal muscle mass between esports players and non-esports players
    Zhi H. SEE, Mohamad S. ABDUL HAMID
    Gazzetta Medica Italiana Archivio per le Scienze Mediche.2022;[Epub]     CrossRef
  • Impact of the Nutrition–Inflammation Status on the Functionality of Patients with Chronic Kidney Disease
    Ángel Nogueira, Graciela Álvarez, Guillermina Barril
    Nutrients.2022; 14(22): 4745.     CrossRef
  • Does Timing Matter? A Narrative Review of Intermittent Fasting Variants and Their Effects on Bodyweight and Body Composition
    Alan A. Aragon, Brad J. Schoenfeld
    Nutrients.2022; 14(23): 5022.     CrossRef
  • Sex- and region-specific associations of skeletal muscle mass with metabolic dysfunction-associated fatty liver disease
    Pei Xiao, Pu Liang, Panjun Gao, Jinyi Wu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study
    Takahiro Tomiyama, Noboru Harada, Takeo Toshima, Yuki Nakayama, Katsuya Toshida, Akinari Morinaga, Yukiko Kosai-Fujimoto, Takahiro Tomino, Takeshi Kurihara, Kazuki Takeishi, Yoshihiro Nagao, Kazutoyo Morita, Shinji Itoh, Tomoharu Yoshizumi
    Transplant International.2022;[Epub]     CrossRef
  • Handgrip Strength Is Associated with Metabolic Syndrome and Insulin Resistance in Children and Adolescents: Analysis of Korea National Health and Nutrition Examination Survey 2014–2018
    Hae Woon Jung, Jieun Lee, Jaehyun Kim
    Journal of Obesity & Metabolic Syndrome.2022; 31(4): 334.     CrossRef
  • Diet quality and a traditional dietary pattern predict lean mass in Australian women: Longitudinal data from the Geelong Osteoporosis Study
    Jessica A. Davis, Mohammadreza Mohebbi, Fiona Collier, Amy Loughman, Nitin Shivappa, James R. Hébert, Julie A. Pasco, Felice N. Jacka
    Preventive Medicine Reports.2021; 21: 101316.     CrossRef
  • Association between serum FGF21 level and sarcopenia in older adults
    Hee-Won Jung, Jin Hoon Park, Da Ae Kim, Il-Young Jang, So Jeong Park, Jin Young Lee, Seungjoo Lee, Jeoung Hee Kim, Hyon-Seung Yi, Eunju Lee, Beom-Jun Kim
    Bone.2021; 145: 115877.     CrossRef
  • Benchside to the bedside of frailty and cardiovascular aging: Main shared cellular and molecular mechanisms
    Sandra Maria Barbalho, Ricardo José Tofano, Eduardo Federigui Baisi Chagas, Cláudia Rucco Penteado Detregiachi, Ricardo de Alvares Goulart, Uri Arian Princ Flato
    Experimental Gerontology.2021; 148: 111302.     CrossRef
  • Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults
    Da Ae Kim, So Jeong Park, Jin Young Lee, Jeoung Hee Kim, Seungjoo Lee, Eunju Lee, Il-Young Jang, Hee-Won Jung, Jin Hoon Park, Beom-Jun Kim
    Endocrinology and Metabolism.2021; 36(2): 455.     CrossRef
  • Sarcopenic obesity as a determinant of cardiovascular disease risk in older people: a systematic review
    Katherine Evans, Dima Abdelhafiz, Ahmed H Abdelhafiz
    Postgraduate Medicine.2021; 133(8): 831.     CrossRef
  • Decreased continuous sitting time increases heart rate variability in patients with cardiovascular risk factors
    Natsuki Nakayama, Masahiko Miyachi, Koji Tamakoshi, Toshio Hayashi, Koji Negi, Koji Watanabe, Makoto Hirai, Sharon Mary Brownie
    PLOS ONE.2021; 16(6): e0253399.     CrossRef
  • Muskeltraining – ein universelles Medikament
    Wolfgang Laube
    Manuelle Medizin.2021; 59(3): 179.     CrossRef
  • The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans
    Liya Kerem, Elizabeth A. Lawson
    International Journal of Molecular Sciences.2021; 22(14): 7737.     CrossRef
  • Weight Loss Strategies and the Risk of Skeletal Muscle Mass Loss
    David McCarthy, Aloys Berg
    Nutrients.2021; 13(7): 2473.     CrossRef
  • Association of FGF‐19 and FGF‐21 levels with primary sarcopenia
    Rabia Bag Soytas, Veysel Suzan, Pinar Arman, Tugce Emiroglu Gedik, Damla Unal, Mahir Cengiz, Ibrahim Murat Bolayirli, Deniz Suna Erdincler, Alper Doventas, Hakan Yavuzer
    Geriatrics & Gerontology International.2021; 21(10): 959.     CrossRef
  • Der Muskulatur mehr Aufmerksamkeit schenken!
    Wolfgang Laube
    Manuelle Medizin.2021; 59(4): 302.     CrossRef
  • Methodology, clinical applications, and future directions of body composition analysis using computed tomography (CT) images: A review
    Antti Tolonen, Tomppa Pakarinen, Antti Sassi, Jere Kyttä, William Cancino, Irina Rinta-Kiikka, Said Pertuz, Otso Arponen
    European Journal of Radiology.2021; 145: 109943.     CrossRef
  • Waist and hip circumference are independently associated with the risk of liver disease in population‐based studies
    Oscar Danielsson, Markku J. Nissinen, Antti Jula, Veikko Salomaa, Satu Männistö, Annamari Lundqvist, Markus Perola, Fredrik Åberg
    Liver International.2021; 41(12): 2903.     CrossRef
  • Understanding of sarcopenia: from definition to therapeutic strategies
    Jee Won Kim, Ryuni Kim, Hyerim Choi, Sang-Jin Lee, Gyu-Un Bae
    Archives of Pharmacal Research.2021; 44(9-10): 876.     CrossRef
  • Muscle strength and its association with cardiometabolic variables in adolescents: does the expression of muscle strength values matter?
    Tiago Rodrigues de Lima, Xuemei Sui, Luiz Rodrigo Augustemak de Lima, Diego Augusto Santos Silva
    World Journal of Pediatrics.2021; 17(6): 597.     CrossRef
  • Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults
    Yeliana L. Sánchez, Manuela Yepes-Calderón, Luis Valbuena, Andrés F. Milán, María C. Trillos-Almanza, Sergio Granados, Miguel Peña, Mauricio Estrada-Castrillón, Juan C. Aristizábal, Raúl Narvez-Sanchez, Jaime Gallo-Villegas, Juan C. Calderón
    Endocrinology and Metabolism.2021; 36(5): 1055.     CrossRef
  • Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications
    Sandra Maria Barbalho, Uri Adrian Prync Flato, Ricardo José Tofano, Ricardo de Alvares Goulart, Elen Landgraf Guiguer, Cláudia Rucco P. Detregiachi, Daniela Vieira Buchaim, Adriano Cressoni Araújo, Rogério Leone Buchaim, Fábio Tadeu Rodrigues Reina, Piero
    International Journal of Molecular Sciences.2020; 21(10): 3607.     CrossRef
  • Prevalence of Metabolic Syndrome and Association with Grip Strength in Older Adults: Findings from the HOPE Study


    Reshma Aziz Merchant, Yiong Huak Chan, Jia Yi Lim, John E Morley
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 2677.     CrossRef
  • Lower Serum n-3 Fatty Acid Level in Older Adults with Sarcopenia
    Il-Young Jang, Hee-Won Jung, Jin Hoon Park, Jeoung Hee Kim, Seungjoo Lee, Eunju Lee, Jin Young Lee, So Jeong Park, Da Ae Kim, Su Jung Kim, Hyun Ju Yoo, Beom-Jun Kim
    Nutrients.2020; 12(10): 2959.     CrossRef
  • Advances in understanding of health‐promoting benefits of medicine and food homology using analysis of gut microbiota and metabolomics
    Minmin Yang, Tao Yan, Meng Yu, Jie Kang, Ruoxi Gao, Peng Wang, Yuhuan Zhang, Huafeng Zhang, Lin Shi
    Food Frontiers.2020; 1(4): 398.     CrossRef
  • The association of circulating kynurenine, a tryptophan metabolite, with frailty in older adults
    Il-Young Jang, Jin Hoon Park, Jeoung Hee Kim, Seungjoo Lee, Eunju Lee, Jin Young Lee, So Jeong Park, Da Ae Kim, Mark W. Hamrick, Beom-Jun Kim
    Aging.2020; 12(21): 22253.     CrossRef
  • Sarcopenia and Muscle Aging: A Brief Overview
    Tam Dao, Alexander E. Green, Yun A Kim, Sung-Jin Bae, Ki-Tae Ha, Karim Gariani, Mi-ra Lee, Keir J. Menzies, Dongryeol Ryu
    Endocrinology and Metabolism.2020; 35(4): 716.     CrossRef
Close layer
Review Articles
Adrenal gland
Congenital Hypogonadotropic Hypogonadism and Kallmann Syndrome: Past, Present, and Future
Soo-Hyun Kim
Endocrinol Metab. 2015;30(4):456-466.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.456
  • 7,493 View
  • 113 Download
  • 68 Web of Science
  • 65 Crossref
AbstractAbstract PDFPubReader   

The proper development and coordination of the hypothalamic-pituitary-gonadal (HPG) axis are essential for normal reproductive competence. The key factor that regulates the function of the HPG axis is gonadotrophin-releasing hormone (GnRH). Timely release of GnRH is critical for the onset of puberty and subsequent sexual maturation. Misregulation in this system can result in delayed or absent puberty and infertility. Congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS) are genetic disorders that are rooted in a GnRH deficiency but often accompanied by a variety of non-reproductive phenotypes such as the loss of the sense of smell and defects of the skeleton, eye, ear, kidney, and heart. Recent progress in DNA sequencing technology has produced a wealth of information regarding the genetic makeup of CHH and KS patients and revealed the resilient yet complex nature of the human reproductive neuroendocrine system. Further research on the molecular basis of the disease and the diverse signal pathways involved will aid in improving the diagnosis, treatment, and management of CHH and KS patients as well as in developing more precise genetic screening and counseling regime.

Citations

Citations to this article as recorded by  
  • In vitro modeling of cranial placode differentiation: Recent advances, challenges, and perspectives
    Casey Griffin, Jean-Pierre Saint-Jeannet
    Developmental Biology.2024; 506: 20.     CrossRef
  • Effects of Exercise on Testosterone and Implications of Drug Abuse: A Review
    Brendan Perreault, Nikki Hammond, Panayotis K. Thanos
    Clinical Neuropharmacology.2023; 46(3): 112.     CrossRef
  • A functional spectrum of PROKR2 mutations identified in isolated hypogonadotropic hypogonadism
    Xinying Wang, Danna Chen, Yaguang Zhao, Meichao Men, Zhiheng Chen, Fang Jiang, Ruizhi Zheng, Maria I Stamou, Lacey Plummer, Ravikumar Balasubramanian, Jia-Da Li
    Human Molecular Genetics.2023; 32(10): 1722.     CrossRef
  • RNF216 affects the stability of STAU2 in the hypothalamus
    Han Yang, Yong Zhu, Xin Li, Zuiming Jiang, Wenting Dai
    Development, Growth & Differentiation.2023; 65(7): 408.     CrossRef
  • Etiology of Male Infertility: an Update
    Indrashis Bhattacharya, Souvik Sen Sharma, Subeer S. Majumdar
    Reproductive Sciences.2023;[Epub]     CrossRef
  • Two Sisters with Kallmann Syndrome, Gonadal Dysgenesis, and Multiple Neuromuscular and Endocrine Disorders: Report of Two Cases with Description of an Unusual Association
    Marta Camacho, Camil Castelo-Branco
    Reproductive Sciences.2022; 29(10): 2859.     CrossRef
  • A Molecular Analysis of Neural Olfactory Placode Differentiation in Human Pluripotent Stem Cells
    Rebecca L. Bricker, Uchit Bhaskar, Rossella Titone, Melanie A. Carless, Tiziano Barberi
    Stem Cells and Development.2022; 31(17-18): 507.     CrossRef
  • The use of stimulation tests for the differential diagnosis of delayed puberty in boys. How to increase the specificity of the method?
    Irina Yu. Ioffe, Yulia L. Skorodok, Elena V. Plotnikova, Irena I. Nagornaya, Ksenia O. Nagovitsyna, Lyudmila A. Jelenina
    Pediatrician (St. Petersburg).2022; 13(3): 15.     CrossRef
  • The diagnostic value of the olfactory evaluation for congenital hypogonadotropic hypogonadism
    Bingqing Yu, Kepu Chen, Jiangfeng Mao, Bo Hou, Hui You, Xi Wang, Min Nie, Qibin Huang, Rui Zhang, Yiyi Zhu, Bang Sun, Feng Feng, Wen Zhou, Xueyan Wu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Genetic analysis of failed male puberty using whole exome sequencing
    Maleeha Akram, David J. Handelsman, Mazhar Qayyum, Marina Kennerson, Sania Rauf, Shahid Ahmed, Osama Ishtiaq, Muhammad Ismail, Qaisar Mansoor, Afzaal Ahmed Naseem, Syed Shakeel Raza Rizvi
    Journal of Pediatric Endocrinology and Metabolism.2022; 35(11): 1410.     CrossRef
  • Genetics of congenital olfactory dysfunction: a systematic review of the literature
    Matthias Deller, Janine Gellrich, Elisabeth C Lohrer, Valentin A Schriever
    Chemical Senses.2022;[Epub]     CrossRef
  • Testicular ultrasound in a patient with Kallmann syndrome: A case report
    Daniela Donat, Sonja Lukac, Ivana Bajkin, Ivana Vorgucin, Viktor Till, Sladjana Zagorac
    Medicinski pregled.2022; 75(7-8): 247.     CrossRef
  • Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4 variants in a large Chinese cohort with isolated hypogonadotropic hypogonadism
    Meichao Men, Xinying Wang, Jiayu Wu, Wang Zeng, Fang Jiang, Ruizhi Zheng, Jia-Da Li
    Journal of Medical Genetics.2021; 58(1): 66.     CrossRef
  • Conditional Fgfr1 Deletion in GnRH Neurons Leads to Minor Disruptions in the Reproductive Axis of Male and Female Mice
    Cynthia Dela Cruz, Cassandra A. Horton, Kelsey N. Sanders, Nathan D. Andersen, Pei-San Tsai
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • A case report of congenital idiopathic hypogonadotropic hypogonadism caused by novel mutation of GNRHR gene
    Liping Wang, Weisheng Lin, Xiaohong Li, Lijuan Zhang, Kai Wang, Xiaoli Cui, Shanmei Tang, Guangguang Fang, Yan Tan, Xuelai Wang, Chuan Chen, Chuanchun Yang, Huiru Tang
    Medicine.2021; 100(5): e24007.     CrossRef
  • RNF216 regulates meiosis and PKA stability in the testes
    Dengfeng Li, Fangfang Li, Lanlan Meng, Huafang Wei, Qianjun Zhang, Fang Jiang, Dan‐Na Chen, Wei Li, Yue‐Qiu Tan, Jia‐Da Li
    The FASEB Journal.2021;[Epub]     CrossRef
  • Congenital Hypogonadotropic Hypogonadism with Early-Onset Coronary Artery Disease
    Akira Takashima, Shusuke Yagi, Koji Yamaguchi, Kiyoe Kurahashi, Yuko Kojima, Robert Zheng, Takayuki Ise, Kenya Kusunose, Sumiko Yoshida, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masashi Akaike, Masataka Sata
    The Journal of Medical Investigation.2021; 68(1.2): 189.     CrossRef
  • The Differential Roles for Neurodevelopmental and Neuroendocrine Genes in Shaping GnRH Neuron Physiology and Deficiency
    Roberto Oleari, Valentina Massa, Anna Cariboni, Antonella Lettieri
    International Journal of Molecular Sciences.2021; 22(17): 9425.     CrossRef
  • Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism
    Meichao Men, Dan‐Na Chen, Jia‐Da Li, Xinying Wang, Wang Zeng, Fang Jiang, Ruizhi Zheng, Wenting Dai
    Molecular Genetics & Genomic Medicine.2021;[Epub]     CrossRef
  • A Novel SEMA3G Mutation in Two Siblings Affected by Syndromic GnRH Deficiency
    Roberto Oleari, Valentina André, Antonella Lettieri, Sophia Tahir, Lise Roth, Alyssa Paganoni, Ivano Eberini, Chiara Parravicini, Valeria Scagliotti, Ludovica Cotellessa, Francesco Bedogni, Lisa Benedetta De Martini, Maria Vittoria Corridori, Simona Gulli
    Neuroendocrinology.2021; 111(5): 421.     CrossRef
  • A novel heterozygous intron mutation in SEMA7A causing kallmann syndrome in a female
    Yongting Zhao, Fan Yang, Lili Qiu, Lihong Wang, Hui Che
    Gynecological Endocrinology.2020; 36(3): 218.     CrossRef
  • Phenotypic Spectrum of Idiopathic Hypogonadotropic Hypogonadism Patients With CHD7 Variants From a Large Chinese Cohort
    Jia-Da Li, Jiayu Wu, Yaguang Zhao, Xinying Wang, Fang Jiang, Qiao Hou, Dan-Na Chen, Ruizhi Zheng, Renhe Yu, Wei Zhou, Meichao Men
    The Journal of Clinical Endocrinology & Metabolism.2020; 105(5): 1515.     CrossRef
  • Genotypic and phenotypic spectra of FGFR1, FGF8, and FGF17 mutations in a Chinese cohort with idiopathic hypogonadotropic hypogonadism
    Meichao Men, Jiayu Wu, Yaguang Zhao, Xiaoliang Xing, Fang Jiang, Ruizhi Zheng, Jia-Da Li
    Fertility and Sterility.2020; 113(1): 158.     CrossRef
  • Posttranslational Modification Defects in Fibroblast Growth Factor Receptor 1 as a Reason for Normosmic Isolated Hypogonadotropic Hypogonadism
    Hui Ying, Yan Sun, Huixiao Wu, Wenyu Jia, Qingbo Guan, Zhao He, Ling Gao, Jiajun Zhao, Yiming Ji, Guimei Li, Chao Xu, Fabio Altieri
    Oxidative Medicine and Cellular Longevity.2020; 2020: 1.     CrossRef
  • CHD7 missense variants and clinical characteristics of Chinese males with infertility
    Leilei Li, Ruixue Wang, Yang Yu, Hongguo Zhang, Yuting Jiang, Xiao Yang, Ruizhi Liu
    Molecular Genetics & Genomic Medicine.2020;[Epub]     CrossRef
  • Lifestyle, metabolic disorders and male hypogonadism – A one-way ticket?
    Luís Crisóstomo, Sara C. Pereira, Mariana P. Monteiro, João F. Raposo, Pedro F. Oliveira, Marco G. Alves
    Molecular and Cellular Endocrinology.2020; 516: 110945.     CrossRef
  • GnRH Deficient Patients With Congenital Hypogonadotropic Hypogonadism: Novel Genetic Findings in ANOS1, RNF216, WDR11, FGFR1, CHD7, and POLR3A Genes in a Case Series and Review of the Literature
    Vassos Neocleous, Pavlos Fanis, Meropi Toumba, George A. Tanteles, Melpo Schiza, Feride Cinarli, Nicolas C. Nicolaides, Anastasis Oulas, George M. Spyrou, Christos S. Mantzoros, Dimitrios Vlachakis, Nicos Skordis, Leonidas A. Phylactou
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Eje hipotálamo hipofisario. Fisiología y patología
    M. Araujo-Castro, E. Pascual-Corrales, A.E. Ortiz-Flores, H.F. Escobar-Morreale
    Medicine - Programa de Formación Médica Continuada Acreditado.2020; 13(15): 846.     CrossRef
  • WD40-Repeat Proteins in Ciliopathies and Congenital Disorders of Endocrine System
    Yeonjoo Kim, Soo-Hyun Kim
    Endocrinology and Metabolism.2020; 35(3): 494.     CrossRef
  • Eight rare urinary disorders in a patient with Kallmann syndrome
    Huining Tian, Zi Yan, You Lv, Lin Sun, Xiaokun Gang, Guixia Wang
    Medicine.2020; 99(43): e22936.     CrossRef
  • Delayed and Precocious Puberty: Genetic Underpinnings and Treatments
    Anisha Gohil, Erica A. Eugster
    Endocrinology and Metabolism Clinics of North America.2020; 49(4): 741.     CrossRef
  • Disorders of Sex Development: Classification, Review, and Impact on Fertility
    Pedro Acién, Maribel Acién
    Journal of Clinical Medicine.2020; 9(11): 3555.     CrossRef
  • A nonsense variant in FGFR1: a rare cause of combined pituitary hormone deficiency
    İbrahim Mert Erbaş, Ahu Paketçi, Sezer Acar, Leman Damla Kotan, Korcan Demir, Ayhan Abacı, Ece Böber
    Journal of Pediatric Endocrinology and Metabolism.2020; 33(12): 1613.     CrossRef
  • Kallman syndrome and central non-obstructive azoospermia
    Sameer Thakker, Jesse Persily, Bobby B. Najari
    Best Practice & Research Clinical Endocrinology & Metabolism.2020; 34(6): 101475.     CrossRef
  • RNF216 Regulates the Migration of Immortalized GnRH Neurons by Suppressing Beclin1-Mediated Autophagy
    Fangfang Li, Dengfeng Li, Huadie Liu, Bei-Bei Cao, Fang Jiang, Dan-Na Chen, Jia-Da Li
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Parallel Multi-Gene Panel Testing for Diagnosis of Idiopathic Hypogonadotropic Hypogonadism/Kallmann Syndrome
    Manickavasagam Senthilraja, Aaron Chapla, Felix K. Jebasingh, Dukhabhandhu Naik, Thomas V. Paul, Nihal Thomas
    Case Reports in Genetics.2019; 2019: 1.     CrossRef
  • Screening for mutations in selected miRNA genes in hypogonadotropic hypogonadism patients
    Anna-Pauliina Iivonen, Johanna Känsäkoski, Kirsi Vaaralahti, Taneli Raivio
    Endocrine Connections.2019; 8(5): 506.     CrossRef
  • Live birth in male de novo Kallmann syndrome after cross-generational genetic sequencing
    Cindy Chan, Cheng-Wei Wang, Ching-Hui Chen, Chi-Huang Chen
    Journal of Assisted Reproduction and Genetics.2019; 36(12): 2481.     CrossRef
  • Is Hormonal Treatment of Congenital Undescended Testes Justified A Debate
    Faruk Hadziselimovic
    Sexual Development.2019; 13(1): 3.     CrossRef
  • High frequency of CHD7 mutations in congenital hypogonadotropic hypogonadism
    Catarina Inês Gonçalves, Filipa Marina Patriarca, José Maria Aragüés, Davide Carvalho, Fernando Fonseca, Sofia Martins, Olinda Marques, Bernardo Dias Pereira, José Martinez-de-Oliveira, Manuel Carlos Lemos
    Scientific Reports.2019;[Epub]     CrossRef
  • PROKR2mutations in idiopathic hypogonadotropic hypogonadism: selective disruption of the binding to aGα‐protein leads to biased signaling
    Yaguang Zhao, Jiayu Wu, Hong Jia, Xinying Wang, Ruizhi Zheng, Fang Jiang, Dan-Na Chen, Zhiheng Chen, Jia-Da Li
    The FASEB Journal.2019; 33(3): 4538.     CrossRef
  • Congenital diaphragmatic hernia is associated with nonscrotal testes
    Stan Janssen, Kim Heiwegen, Iris ALM van Rooij, Janielle van Alfen-van der Velden, Ivo de Blaauw, Sanne MBI Botden
    Journal of Pediatric Surgery.2019; 54(3): 445.     CrossRef
  • Cranial Pair 0: The Nervus Terminalis
    Ángel Peña‐Melián, Juan Pablo Cabello‐de la Rosa, Maria José Gallardo‐Alcañiz, Julia Vaamonde‐Gamo, Fernanda Relea‐Calatayud, Lucía González‐López, Patricia Villanueva‐Anguita, Alicia Flores‐Cuadrado, Daniel Saiz‐Sánchez, Alino Martínez‐Marcos
    The Anatomical Record.2019; 302(3): 394.     CrossRef
  • Semaphorin Signaling in GnRH Neurons: From Development to Disease
    Roberto Oleari, Antonella Lettieri, Alyssa Paganoni, Luca Zanieri, Anna Cariboni
    Neuroendocrinology.2019; 109(3): 193.     CrossRef
  • Whole Exome Sequencing Revealed a Novel Nonsense Variant in the GNRHR Gene Causing Normosmic Hypogonadotropic Hypogonadism in a Pakistani Family
    Hafiz Muhammad Jafar Hussain, Ghulam Murtaza, Xiaohua Jiang, Ranjha Khan, Manan Khan, Mian Basit Shah Kakakhel, Teka Khan, Fazal Wahab, Huan Zhang, Yuanwei Zhang, Muhammad Bilal Khan, Parvez Ahmed, Hui Ma, Zhipeng Xu
    Hormone Research in Paediatrics.2019; 91(1): 9.     CrossRef
  • New intronic Fibroblast Growth Factor Receptor 1 (FGFR1) mutation leading to disrupted splicing and Kallmann syndrome
    J Känsäkoski, K Vaaralahti, T Raivio
    Human Reproduction.2018; 33(2): 328.     CrossRef
  • Rare cause of manic period trigger in bipolar mood disorder: testosterone replacement
    Gulcin Elboga, Zeynel Abidin Sayiner
    BMJ Case Reports.2018; : bcr-2018-225108.     CrossRef
  • WDR11‐mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome
    Yeon‐Joo Kim, Daniel PS Osborn, Ji‐Young Lee, Masatake Araki, Kimi Araki, Timothy Mohun, Johanna Känsäkoski, Nina Brandstack, Hyun‐Taek Kim, Francesc Miralles, Cheol‐Hee Kim, Nigel A Brown, Hyung‐Goo Kim, Juan Pedro Martinez‐Barbera, Paris Ataliotis, Tane
    EMBO reports.2018; 19(2): 269.     CrossRef
  • A rare ANOS1 variant in siblings with Kallmann syndrome identified by whole exome sequencing
    D. M. Lopategui, A. J. Griswold, H. Arora, R. I. Clavijo, M. Tekin, R. Ramasamy
    Andrology.2018; 6(1): 53.     CrossRef
  • Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
    L M Huckins, K Hatzikotoulas, L Southam, L M Thornton, J Steinberg, F Aguilera-McKay, J Treasure, U Schmidt, C Gunasinghe, A Romero, C Curtis, D Rhodes, J Moens, G Kalsi, D Dempster, R Leung, A Keohane, R Burghardt, S Ehrlich, J Hebebrand, A Hinney, A Lud
    Molecular Psychiatry.2018; 23(5): 1169.     CrossRef
  • The hypothalamus-pituitary-gonad axis: Tales of mice and men
    Athina Kaprara, Ilpo T. Huhtaniemi
    Metabolism.2018; 86: 3.     CrossRef
  • Assisted reproductive techniques with congenital hypogonadotropic hypogonadism patients: a systematic review and meta-analysis
    Yinjie Gao, Bingqing Yu, Jiangfeng Mao, Xi Wang, Min Nie, Xueyan Wu
    BMC Endocrine Disorders.2018;[Epub]     CrossRef
  • A novel PNPLA6 compound heterozygous mutation identified in a Chinese patient with Boucher‑Neuh�user syndrome
    Ruizhi Zheng, Yaguang Zhao, Jiayu Wu, Yuanmei Wang, Jian‑Ling Liu, Zhi‑Ling Zhou, Xiao‑Tao Zhou, Dan‑Na Chen, Wei‑Hua Liao, Jia‑Da Li
    Molecular Medicine Reports.2018;[Epub]     CrossRef
  • A dominant negative FGFR1 mutation identified in a Kallmann syndrome patient
    Hunjin Luo, Ruizhi Zheng, Yaguang Zhao, Jiayu Wu, Jie Li, Fang Jiang, Dan-Na Chen, Xiao-Tao Zhou, Jia-Da Li
    Gene.2017; 621: 1.     CrossRef
  • Characterization of an X-chromosomal non-mosaic monosomy (59, X0) dairy heifer detected using routinely available single nucleotide polymorphism genotype data1
    D. P. Berry, A. Wolfe, J. O'Donovan, N. Byrne, R. G. Sayers, K. G. Dodds, J. C. McEwan, R. E. O'Connor, M. McClure, D. C. Purfield
    Journal of Animal Science.2017; 95(3): 1042.     CrossRef
  • Genetic basis of eugonadal and hypogonadal female reproductive disorders
    Tatiana Trofimova, Daria Lizneva, Larisa Suturina, Walidah Walker, Yen-Hao Chen, Ricardo Azziz, Lawrence C. Layman
    Best Practice & Research Clinical Obstetrics & Gynaecology.2017; 44: 3.     CrossRef
  • Loss of microRNA-7a2 induces hypogonadotropic hypogonadism and infertility
    Kashan Ahmed, Mary P. LaPierre, Emanuel Gasser, Rémy Denzler, Yinjie Yang, Thomas Rülicke, Jukka Kero, Mathieu Latreille, Markus Stoffel
    Journal of Clinical Investigation.2017; 127(3): 1061.     CrossRef
  • Next-generation sequencing of patients with congenital anosmia
    Anna Alkelai, Tsviya Olender, Catherine Dode, Sagit Shushan, Pavel Tatarskyy, Edna Furman-Haran, Valery Boyko, Ruth Gross-Isseroff, Matthew Halvorsen, Lior Greenbaum, Roni Milgrom, Kazuya Yamada, Ayumi Haneishi, Ilan Blau, Doron Lancet
    European Journal of Human Genetics.2017; 25(12): 1377.     CrossRef
  • Analysis of genetic and clinical characteristics of a Chinese Kallmann syndrome cohort with ANOS1 mutations
    Min Nie, Hongli Xu, Rongrong Chen, Jiangfeng Mao, Xi Wang, Shuyu Xiong, Junjie Zheng, Bingqing Yu, Mingxuan Cui, Wanlu Ma, Qibin Huang, Hongbing Zhang, Xueyan Wu
    European Journal of Endocrinology.2017; 177(4): 389.     CrossRef
  • Kallmann syndrome in pediatric otorhinolaryngology practice – Case report and literature review
    Karolina Dżaman, Karolina Zborowska – Piskadło, Mirosława Pietniczka – Załęska, Ireneusz Kantor
    International Journal of Pediatric Otorhinolaryngology.2017; 100: 149.     CrossRef
  • A heterozygous microdeletion of 20p12.2–3 encompassing PROKR2 and BMP2 in a patient with congenital hypopituitarism and growth hormone deficiency
    Samuel J. H. Parsons, Neville B. Wright, Emma Burkitt‐Wright, Mars S. Skae, Phillip G. Murray
    American Journal of Medical Genetics Part A.2017; 173(8): 2261.     CrossRef
  • Arachnoid cyst: a further anomaly associated with Kallmann syndrome?
    Luca Massimi, Alessandro Izzo, Giovanna Paternoster, Paolo Frassanito, Concezio Di Rocco
    Child's Nervous System.2016; 32(9): 1607.     CrossRef
  • What do we learn from the murineJacob/Nsmfgene knockout for human disease?
    Christina Spilker, Katarzyna M. Grochowska, Michael R. Kreutz
    Rare Diseases.2016; 4(1): e1241361.     CrossRef
  • Sexuality and quality of life in congenital hypogonadisms
    María Fernanda Garrido Oyarzún, Camil Castelo-Branco
    Gynecological Endocrinology.2016; 32(12): 947.     CrossRef
  • Gene Expression Changes Underlying Idiopathic Central Hypogonadism in Cryptorchidism with Defective Mini-Puberty
    Faruk Hadziselimovic, Katharina Gegenschatz-Schmid, Gilvydas Verkauskas, Maria J. Docampo-Garcia, Philippe Demougin, Vytautas Bilius, Dalius Malcius, Darius Dasevicius, Michael B. Stadtler
    Sexual Development.2016; 10(3): 136.     CrossRef
Close layer
Obesity and Metabolism
Nonalcoholic Fatty Liver Disease and Diabetes: An Epidemiological Perspective
Eun-Jung Rhee
Endocrinol Metab. 2019;34(3):226-233.   Published online September 26, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.3.226
  • 10,301 View
  • 305 Download
  • 64 Web of Science
  • 64 Crossref
AbstractAbstract PDFPubReader   ePub   

Nonalcoholic fatty liver disease (NAFLD) is thought to stem from the body's inability to store excess energy in adipocytes; as such, it is commonly viewed as the hepatic manifestation of metabolic syndrome. The pathogenesis of NAFLD involves ectopic fat accumulation, which also takes place in the liver, muscle and visceral fat. NAFLD is rapidly becoming more widespread in Korea, with an estimated prevalence of 30% in adults. Type 2 diabetes mellitus (T2DM) and NAFLD share insulin resistance as a common pathophysiological mechanism, and each of these two diseases affects the development of the other. Recent studies have suggested that NAFLD is often present as a comorbidity in T2DM patients. The mutual interrelationship between these conditions is shown by findings suggesting that T2DM can exacerbate NAFLD by promoting progression to nonalcoholic hepatosteatosis or fibrosis, while NAFLD causes the natural course of diabetic complications to worsen in T2DM patients. It remains unknown whether one disease is the cause of the other or vice versa. In this review, I would like to discuss current epidemiological data on the associations between NAFLD and T2DM, and how each disease affects the course of the other.

Citations

Citations to this article as recorded by  
  • Effect of exercise intervention on clinical parameters in patients with non-alcoholic fatty liver disease and type 2 diabetes mellitus: a meta-analysis of randomized controlled trials
    Yu Zeng, Xuemei Zhang, Wenling Luo, Yunjian Sheng
    European Journal of Gastroenterology & Hepatology.2024; 36(1): 1.     CrossRef
  • Phase 2, open-label, rollover study of cenicriviroc for liver fibrosis associated with metabolic dysfunction–associated steatohepatitis
    Sven M. Francque, Alexander Hodge, Jerome Boursier, Ziad H. Younes, Gerardo Rodriguez-Araujo, Grace S. Park, Naim Alkhouri, Manal F. Abdelmalek
    Hepatology Communications.2024;[Epub]     CrossRef
  • Utility of Indices Obtained during Medical Checkups for Predicting Fatty Liver Disease in Non-obese People
    Naoya Otsubo, Tatsuya Fukuda, Genhin Cho, Fumiaki Ishibashi, Tetsuya Yamada, Koshiro Monzen
    Internal Medicine.2023; 62(16): 2307.     CrossRef
  • Liraglutide on type 2 diabetes mellitus with nonalcoholic fatty liver disease: A systematic review and meta-analysis of 16 RCTs
    Yan Zhao, Wenli Zhao, Huaien Bu, Maeda Toshiyoshi, Ye Zhao
    Medicine.2023; 102(6): e32892.     CrossRef
  • Metabolic Dysfunction-Associated Fatty Liver Disease and Mortality: A Population-Based Cohort Study
    Kyung-Soo Kim, Sangmo Hong, Hong-Yup Ahn, Cheol-Young Park
    Diabetes & Metabolism Journal.2023; 47(2): 220.     CrossRef
  • Metabolomics analysis reveals serum biomarkers in patients with diabetic sarcopenia
    Yuwei Tan, Xiaosong Liu, Yinping Yang, Baoying Li, Fei Yu, Wenqian Zhao, Chunli Fu, Xin Yu, Zhenxia Han, Mei Cheng
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Antagonizing apolipoprotein J chaperone promotes proteasomal degradation of mTOR and relieves hepatic lipid deposition
    Shuangdi Duan, Nong Qin, Jiayi Pi, Pei Sun, Yating Gao, Lamei Liu, Zenghui Li, Ya Li, Liyang Shi, Qiang Gao, Ye Qiu, Songqing Tang, Chun-Hsiang Wang, Tzu-Ying Chen, Sin-Tian Wang, Kung-Chia Young, Hung-Yu Sun
    Hepatology.2023; 78(4): 1182.     CrossRef
  • The Influence of Metabolic Factors in Patients with Chronic Viral Hepatitis C Who Received Oral Antiviral Treatment
    Oana Irina Gavril, Radu Sebastian Gavril, Florin Mitu, Otilia Gavrilescu, Iolanda Valentina Popa, Diana Tatarciuc, Andrei Drugescu, Andrei Catalin Oprescu, Andreea Gherasim, Laura Mihalache, Irina Mihaela Esanu
    Metabolites.2023; 13(4): 571.     CrossRef
  • The bidirectional relationship between NAFLD and type 2 diabetes: A prospective population-based cohort study
    Minzhen Wang, Yanan Zhao, Yingqian He, Lulu Zhang, Jing Liu, Shan Zheng, Yana Bai
    Nutrition, Metabolism and Cardiovascular Diseases.2023; 33(8): 1521.     CrossRef
  • Visceral fat: A key mediator of NAFLD development and progression
    Savita Bansal, Meenakshi Vachher, Taruna Arora, Bhupender Kumar, Archana Burman
    Human Nutrition & Metabolism.2023; 33: 200210.     CrossRef
  • Greater Severity of Steatosis Is Associated with a Higher Risk of Incident Diabetes: A Retrospective Longitudinal Study
    Ji Min Han, Jung Hwan Cho, Hye In Kim, Sunghwan Suh, Yu-Ji Lee, Jung Won Lee, Kwang Min Kim, Ji Cheol Bae
    Endocrinology and Metabolism.2023; 38(4): 418.     CrossRef
  • The role of TRIM family in metabolic associated fatty liver disease
    Jingyue Zhang, Yingming Zhang, Ze Ren, Dongmei Yan, Guiying Li
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Non-alcoholic fatty liver disease and diabetic retinopathy: Is there an association?
    Mathew Jacob, Mary Joseph, Jyothi Idiculla
    Journal of Family Medicine and Primary Care.2023; 12(9): 2028.     CrossRef
  • Camel whey protein improves diabetic liver injury by targeting ACMSD and promoting de novo NAD+ synthesis
    Zhihua Dou, Huaibin Yao, Yutong Xie, Ying Liu, Yang Gao, Jie Yang
    Journal of Functional Foods.2023; 110: 105835.     CrossRef
  • Gut microbiota and nonalcoholic fatty liver disease
    Boyeon Kim, Bukyung Kim
    Kosin Medical Journal.2023; 38(3): 169.     CrossRef
  • Non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus
    E.G. Mankieva, E.I. Kukhareva
    Dokazatel'naya gastroenterologiya.2023; 12(4): 103.     CrossRef
  • Body Fat Distribution, Glucose Metabolism, and Diabetes Status Among Older Adults: The Multiethnic Cohort Adiposity Phenotype Study
    Gertraud Maskarinec, Phyllis Raquinio, Bruce S. Kristal, Adrian A. Franke, Steven D. Buchthal, Thomas M. Ernst, Kristine R. Monroe, John A. Shepherd, Yurii B. Shvetsov, Loïc Le Marchand, Unhee Lim
    Journal of Epidemiology.2022; 32(7): 314.     CrossRef
  • Evaluation of the reciprocal interaction between hepatic steatosis and type 2 diabetes: a comparative analysis with respect to anti-diabetic treatment, glycemic control, renal and hepatic function
    Teslime Ayaz, Hatice Beyazal Polat, Bilgesah Kilictas
    International Journal of Diabetes in Developing Countries.2022; 42(3): 421.     CrossRef
  • Glycemic control, the unconsidered outcome in the treatment of nonalcoholic fatty liver disease
    Diego García-Compeán, Emanuela Orsi, Tsutomu Nishida, Ramesh Kumar
    Annals of Hepatology.2022; 27(1): 100648.     CrossRef
  • Prevalence of High and Moderate Risk Nonalcoholic Fatty Liver Disease Among Adults in the United States, 1999–2016
    Pegah Golabi, James M. Paik, Michael Harring, Elena Younossi, Khaled Kabbara, Zobair M. Younossi
    Clinical Gastroenterology and Hepatology.2022; 20(12): 2838.     CrossRef
  • The Influence of Obesity and Metabolic Health on Vascular Health
    Eun-Jung Rhee
    Endocrinology and Metabolism.2022; 37(1): 1.     CrossRef
  • Lifestyle as well as metabolic syndrome and non-alcoholic fatty liver disease: an umbrella review of evidence from observational studies and randomized controlled trials
    Xiaojuan Peng, Juan Li, Hailiang Zhao, Junlong Lai, Junqin Lin, Shaohui Tang
    BMC Endocrine Disorders.2022;[Epub]     CrossRef
  • The Impact of Insulin Resistance on Hepatic Fibrosis among United States Adults with Non-Alcoholic Fatty Liver Disease: NHANES 2017 to 2018
    Ji Cheol Bae, Lauren A. Beste, Kristina M. Utzschneider
    Endocrinology and Metabolism.2022; 37(3): 455.     CrossRef
  • Extra-Glycemic Effects of Anti-Diabetic Medications: Two Birds with One Stone?
    Eun-Jung Rhee
    Endocrinology and Metabolism.2022; 37(3): 415.     CrossRef
  • Structurally‐engineered fatty acid 1024 (SEFA‐1024) improves diet‐induced obesity, insulin resistance, and fatty liver disease
    Jordon D. Secor, Bennet S. Cho, Lumeng J. Yu, Amy Pan, Victoria H. Ko, Duy T. Dao, Michael Feigh, Lorenzo Anez‐Bustillos, Gillian L. Fell, David A. Fraser, Kathleen M. Gura, Mark Puder
    Lipids.2022; 57(4-5): 241.     CrossRef
  • Impact of COVID-19 Lockdown on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in Adults: A before and after Pandemic Lockdown Longitudinal Study
    Ángel Arturo López-González, Bárbara Altisench Jané, Luis Masmiquel Comas, Sebastiana Arroyo Bote, Hilda María González San Miguel, José Ignacio Ramírez Manent
    Nutrients.2022; 14(14): 2795.     CrossRef
  • Captopril and Spironolactone can Attenuate Diabetic Nephropathy in Wistar Rats by Targeting ABCA1 and microRNA-33
    Tina Ghaffari, Nariman Moradi, Elham Chamani, Zahra Ebadi, Reza Fadaei, Shahin Alizadeh-Fanalou, Sahar Yarahmadi, Soudabeh Fallah
    Current Pharmaceutical Design.2022; 28(16): 1367.     CrossRef
  • Elevated serum γ-glutamyl transferase is associated with low muscle function in adults independent of muscle mass
    Seunghyun Lee, Dawon Song, Sungjae Shin, Namki Hong, Yumie Rhee
    Nutrition.2022; 103-104: 111813.     CrossRef
  • Cross-sectional association between prolactin levels and non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus: a retrospective analysis of patients from a single hospital in China
    Yuanyuan Zhang, Huaizhen Liu
    BMJ Open.2022; 12(10): e062252.     CrossRef
  • Non-invasive screening, staging and management of metabolic dysfunction-associated fatty liver disease (MAFLD) in type 2 diabetes mellitus patients : what do we know so far ?
    Q Binet, A Loumaye, V Preumont, J-P Thissen, M.P. Hermans, N Lanthier
    Acta Gastro Enterologica Belgica.2022; 85(2): 346.     CrossRef
  • Diosgenin Ameliorated Type II Diabetes-Associated Nonalcoholic Fatty Liver Disease through Inhibiting De Novo Lipogenesis and Improving Fatty Acid Oxidation and Mitochondrial Function in Rats
    Yujie Zhong, Zhiman Li, Ruyi Jin, Yanpeng Yao, Silan He, Min Lei, Xin Wang, Chao Shi, Li Gao, Xiaoli Peng
    Nutrients.2022; 14(23): 4994.     CrossRef
  • Correlation between Component Factors of Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome in Nurses: An Observational and Cross-Sectional Study
    Wen-Pei Chang, Yu-Pei Chang
    International Journal of Environmental Research and Public Health.2022; 19(23): 16294.     CrossRef
  • Recent advances and potentiality of postbiotics in the food industry: Composition, inactivation methods, current applications in metabolic syndrome, and future trends
    Yujie Zhong, Tao Wang, Ruilin Luo, Jiayu Liu, Ruyi Jin, Xiaoli Peng
    Critical Reviews in Food Science and Nutrition.2022; : 1.     CrossRef
  • Holistic analysis of hepatosteatosis literature: a scientometric study of global hepatosteatosis publications between 1980 and 2019
    Fatih ESKİN, Engin ŞENEL
    Journal of Medicine and Palliative Care.2022; 3(4): 300.     CrossRef
  • Terpenoids: Natural Compounds for Non-Alcoholic Fatty Liver Disease (NAFLD) Therapy
    Pengyu Yao, Yajuan Liu
    Molecules.2022; 28(1): 272.     CrossRef
  • Association of Non-Alcoholic Fatty Liver Dis-ease and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus: a Cross-Sectional Study
    Zahra Heidari, Zahra Sharafi
    Iranian South Medical Journal.2022; 25(1): 30.     CrossRef
  • Race and Ethnicity in Non-Alcoholic Fatty Liver Disease (NAFLD): A Narrative Review
    Kiarash Riazi, Mark G. Swain, Stephen E. Congly, Gilaad G. Kaplan, Abdel-Aziz Shaheen
    Nutrients.2022; 14(21): 4556.     CrossRef
  • MAFLD vs. NAFLD: shared features and potential changes in epidemiology, pathophysiology, diagnosis, and pharmacotherapy
    Ying-Xin Xian, Jian-Ping Weng, Fen Xu
    Chinese Medical Journal.2021; 134(1): 8.     CrossRef
  • Factors associated with elevated alanine aminotransferase in employees of a German chemical company: results of a large cross-sectional study
    Matthias Claus, Christoph Antoni, Bernd Hofmann
    BMC Gastroenterology.2021;[Epub]     CrossRef
  • Treatment potential of LPCN 1144 on liver health and metabolic regulation in a non-genomic, high fat diet induced NASH rabbit model
    P. Comeglio, E. Sarchielli, S. Filippi, I. Cellai, G. Guarnieri, A. Morelli, G. Rastrelli, E. Maseroli, S. Cipriani, T. Mello, A. Galli, B. J. Bruno, K. Kim, K. Vangara, K. Papangkorn, N. Chidambaram, M. V. Patel, M. Maggi, L. Vignozzi
    Journal of Endocrinological Investigation.2021; 44(10): 2175.     CrossRef
  • Cellular protein markers, therapeutics, and drug delivery strategies in the treatment of diabetes-associated liver fibrosis
    Chien-Yu Lin, Pratik Adhikary, Kun Cheng
    Advanced Drug Delivery Reviews.2021; 174: 127.     CrossRef
  • Trend for Clinical Use of Metabolic Associated Fatty Liver Disease (MAFLD)
    Hiroshi Bando
    Asploro Journal of Biomedical and Clinical Case Reports.2021; 4(2): 99.     CrossRef
  • Prediction of Cardiovascular Risk Using Nonalcoholic Fatty Liver Disease Scoring Systems
    Ye-Na Kweon, Hae-Jin Ko, A-Sol Kim, Hye-In Choi, Ji-Eun Song, Ji-Yeon Park, Sung-Min Kim, Hee-Eun Hong, Kyung-Jin Min
    Healthcare.2021; 9(7): 899.     CrossRef
  • Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice
    Yongxiang Yu, Dongru Chen, Yuhua Zhao, Jianjun Zhu, Xiaohui Dong
    International Journal of Immunopathology and Pharmacology.2021; 35: 205873842110368.     CrossRef
  • Non-Alcoholic Fatty Liver Disease and Its Association With Diabetes Mellitus
    Jaskamal Padda, Khizer Khalid, Anwar Khedr, Fahriba Tasnim, Ola A Al-Ewaidat, Ayden Charlene Cooper, Gutteridge Jean-Charles
    Cureus.2021;[Epub]     CrossRef
  • Nonalcoholic fatty liver disease and the risk of insulin-requiring gestational diabetes
    Sang Youn You, Kyungdo Han, Seung-Hawn Lee, Mee Kyoung Kim
    Diabetology & Metabolic Syndrome.2021;[Epub]     CrossRef
  • Serum syndecan‐4 is associated with nonalcoholic fatty liver disease
    Shu Jing Xia, Li Zhong Tang, Wen Hua Li, Zhao Shan Xu, Li Li Zhang, Feng Gan Cheng, Hong Xia Chen, Zi Hua Wang, Yu Cheng Luo, An Na Dai, Jian Gao Fan
    Journal of Digestive Diseases.2021; 22(9): 536.     CrossRef
  • Non-Laboratory-Based Simple Screening Model for Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Developed Using Multi-Center Cohorts
    Jiwon Kim, Minyoung Lee, Soo Yeon Kim, Ji-Hye Kim, Ji Sun Nam, Sung Wan Chun, Se Eun Park, Kwang Joon Kim, Yong-ho Lee, Joo Young Nam, Eun Seok Kang
    Endocrinology and Metabolism.2021; 36(4): 823.     CrossRef
  • Grape pomace reduces the severity of non-alcoholic hepatic steatosis and the development of steatohepatitis by improving insulin sensitivity and reducing ectopic fat deposition in mice
    Tehila Daniel, Michaella Ben-Shachar, Elyashiv Drori, Sharleen Hamad, Anna Permyakova, Elad Ben-Cnaan, Joseph Tam, Zohar Kerem, Tovit Rosenzweig
    The Journal of Nutritional Biochemistry.2021; 98: 108867.     CrossRef
  • The Interplay between Insulin Resistance, Inflammation, Oxidative Stress, Base Excision Repair and Metabolic Syndrome in Nonalcoholic Fatty Liver Disease
    Sylwia Ziolkowska, Agata Binienda, Maciej Jabłkowski, Janusz Szemraj, Piotr Czarny
    International Journal of Molecular Sciences.2021; 22(20): 11128.     CrossRef
  • The Leg Fat to Total Fat Ratio Is Associated with Lower Risks of Non-Alcoholic Fatty Liver Disease and Less Severe Hepatic Fibrosis: Results from Nationwide Surveys (KNHANES 2008–2011)
    Hyun Min Kim, Yong-ho Lee
    Endocrinology and Metabolism.2021; 36(6): 1232.     CrossRef
  • Tip 2 Diyabet Modeli Ratların Karaciğer Dokularında Kodlanan Genlerin İfade Düzeyleri
    Lütfiye ÖZPAK, Ayfer PAZARBAŞI
    Ankara Sağlık Bilimleri Dergisi.2021; 10(1): 25.     CrossRef
  • Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders
    Judith Aron-Wisnewsky, Chloé Vigliotti, Julia Witjes, Phuong Le, Adriaan G. Holleboom, Joanne Verheij, Max Nieuwdorp, Karine Clément
    Nature Reviews Gastroenterology & Hepatology.2020; 17(5): 279.     CrossRef
  • Non-alcoholic fatty liver disease and primary care physicians
    Ludovico Abenavoli, Anna C. Procopio, Milica Medić-Stojanoska, Francesco Luzza
    Minerva Gastroenterologica e Dietologica.2020;[Epub]     CrossRef
  • The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease
    Hideki Fujii, Norifumi Kawada
    International Journal of Molecular Sciences.2020; 21(11): 3863.     CrossRef
  • Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway
    Yuanyuan Liu, Mengjie Wang, Wei Xu, Hongman Zhang, Weihe Qian, Xiang Li, Xingbo Cheng
    Life Sciences.2020; 241: 117086.     CrossRef
  • Serum lipoprotein(a) levels and insulin resistance have opposite effects on fatty liver disease
    Inha Jung, Hyemi Kwon, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
    Atherosclerosis.2020; 308: 1.     CrossRef
  • The effect of liraglutide on nonalcoholic fatty liver disease in type 2 diabetes mellitus
    Xueyang Zhang, Ran Bai, Yong Jia, Junwei Zong, Yongbo Wang, Yanan Dong
    International Journal of Diabetes in Developing Countries.2020; 40(4): 491.     CrossRef
  • Association between Thyroid Function and Nonalcoholic Fatty Liver Disease in Euthyroid Type 2 Diabetes Patients
    Bin Huang, Shengju Yang, Shandong Ye
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • The Absence of NLRP3-inflammasome Modulates Hepatic Fibrosis Progression, Lipid Metabolism, and Inflammation in KO NLRP3 Mice during Aging
    Paloma Gallego, Beatriz Castejón-Vega, José A. del Campo, Mario D. Cordero
    Cells.2020; 9(10): 2148.     CrossRef
  • Prevalence of people at risk of developing type 2 diabetes mellitus and the involvement of community pharmacies in a national screening campaign: a pioneer action in Brazil
    Cassyano J. Correr, Wendel Coura-Vital, Josélia C. Q. P. Frade, Renata C. R. M. Nascimento, Lúbia G. Nascimento, Eliete B. Pinheiro, Wesley M. Ferreira, Janice S. Reis, Karla F. S. Melo, Roberto Pontarolo, Mônica S. A. Lenzi, José V. Almeida, Hermelinda C
    Diabetology & Metabolic Syndrome.2020;[Epub]     CrossRef
  • Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease
    Kyung-Soo Kim, Byung-Wan Lee
    Clinical and Molecular Hepatology.2020; 26(4): 430.     CrossRef
  • Elevated TPOAb is a Strong Predictor of Autoimmune Development in Patients of Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: A Case–Control Study


    Chenyi Wang, Qianglong Niu, Haihong Lv, Qian Li, Yuping Ma, Jiaojiao Tan, Chunhua Liu
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 4369.     CrossRef
  • Sarcopoterium spinosum Inhibited the Development of Non-Alcoholic Steatosis and Steatohepatitis in Mice
    Ayala Wollman, Tehila Daniel, Tovit Rosenzweig
    Nutrients.2019; 11(12): 3044.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism