Endocrinology and Metabolism

Case Report

Autoimmune Thyroiditis during Antiviral Therapy with Peginterferon.: Jung Min Roh, Jeong Seon Yoo, Yoon Bum Lee, Hye Rim An, Hong Kyu Choi, Kyo Tae Jung, Jong Suk Park, Kwan Sik Lee, Kyung Rae Kim; J Korean Endocr Soc. 2010;25(1):68-71. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.68

Abstract PDF: Combination treatment with pegylated interferon and ribavirin has been established as a standard therapy for chronic hepatitis C. Although interferon therapy is relatively safe, an important side effect is the induction of autoantibodies and autoimmune disease, especially autoimmune thyroid disease. Interferon associated autoimmune thyroid disease can consist of autoimmune hypothyroidism, Graves' disease, and destructive thyroiditis. Thyroid disease may lead to dose reduction or discontinuation of therapy.

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