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3 "Parathyroid glands"
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Review Articles
Parathyroid Gland Generation from Pluripotent Stem Cells
Mayuko Kano
Received March 25, 2024  Accepted May 7, 2024  Published online June 10, 2024  
DOI: https://doi.org/10.3803/EnM.2024.1989    [Epub ahead of print]
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  • 33 Download
AbstractAbstract PDFPubReader   ePub   
Patients with permanent hypoparathyroidism require lifelong treatment. Current replacement therapies sometimes have adverse effects (e.g., hypercalciuria and chronic kidney disease). Generating parathyroid glands (PTGs) from the patient’s own induced pluripotent stem cells (PSCs), with transplantation of these PTGs, would be an effective treatment option. Multiple methods for generating PTGs from PSCs have been reported. One major trend is in vitro differentiation of PSCs into PTGs. Another is in vivo generation of PSC-derived PTGs by injecting PSCs into PTG-deficient embryos. This review discusses current achievements and challenges in present and future PTG regenerative medicine.
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Miscellaneous
Rare PTH Gene Mutations Causing Parathyroid Disorders: A Review
Joon-Hyop Lee, Munkhtugs Davaatseren, Sihoon Lee
Endocrinol Metab. 2020;35(1):64-70.   Published online March 19, 2020
DOI: https://doi.org/10.3803/EnM.2020.35.1.64
  • 5,369 View
  • 115 Download
  • 9 Web of Science
  • 7 Crossref
AbstractAbstract PDFPubReader   ePub   

Since parathyroid hormone (PTH) was first isolated and its gene (PTH) was sequenced, only eight PTH mutations have been discovered. The C18R mutation in PTH, discovered in 1990, was the first to be reported. This autosomal dominant mutation induces endoplasmic reticulum stress and subsequent apoptosis in parathyroid cells. The next mutation, which was reported in 1992, is associated with exon skipping. The substitution of G with C in the first nucleotide of the second intron results in the exclusion of the second exon; since this exon includes the initiation codon, translation initiation is prevented. An S23P mutation and an S23X mutation at the same residue were reported in 1999 and 2012, respectively. Both mutations resulted in hypoparathyroidism. In 2008, a somatic R83X mutation was detected in a parathyroid adenoma tissue sample collected from a patient with hyperparathyroidism. In 2013, a heterozygous p.Met1_Asp6del mutation was incidentally discovered in a case-control study. Two years later, the R56C mutation was reported; this is the only reported hypoparathyroidism-causing mutation in the mature bioactive part of PTH. In 2017, another heterozygous mutation, M14K, was detected. The discovery of these eight mutations in the PTH gene has provided insights into its function and broadened our understanding of the molecular mechanisms underlying mutation progression. Further attempts to detect other such mutations will help elucidate the functions of PTH in a more sophisticated manner.

Citations

Citations to this article as recorded by  
  • The Intricacies of Renal Phosphate Reabsorption—An Overview
    Valerie Walker
    International Journal of Molecular Sciences.2024; 25(9): 4684.     CrossRef
  • Molecular and Clinical Spectrum of Primary Hyperparathyroidism
    Smita Jha, William F Simonds
    Endocrine Reviews.2023; 44(5): 779.     CrossRef
  • Rare cause of persistent hypocalcaemia in infancy due to PTH gene mutation
    Savita Khadse, Vrushali Satish Takalikar, Radha Ghildiyal, Nikhil Shah
    BMJ Case Reports.2023; 16(9): e256358.     CrossRef
  • Homozygous Ser-1 to Pro-1 mutation in parathyroid hormone identified in hypocalcemic patients results in secretion of a biologically inactive pro-hormone
    Patrick Hanna, Ashok Khatri, Shawn Choi, Severine Brabant, Matti L. Gild, Marie L. Piketty, Bruno Francou, Dominique Prié, John T. Potts, Roderick J. Clifton-Bligh, Agnès Linglart, Thomas J. Gardella, Harald Jüppner
    Proceedings of the National Academy of Sciences.2023;[Epub]     CrossRef
  • Genetics of monogenic disorders of calcium and bone metabolism
    Paul J. Newey, Fadil M. Hannan, Abbie Wilson, Rajesh V. Thakker
    Clinical Endocrinology.2022; 97(4): 483.     CrossRef
  • Homozygous missense variant of PTH (c.166C>T, p.(Arg56Cys)) as the cause of familial isolated hypoparathyroidism in a three-year-old child
    Stine Linding Andersen, Anja Lisbeth Frederiksen, Astrid Bruun Rasmussen, Mette Madsen, Ann-Margrethe Rønholt Christensen
    Journal of Pediatric Endocrinology and Metabolism.2022; 35(5): 691.     CrossRef
  • Novel PTH Gene Mutations Causing Isolated Hypoparathyroidism
    Colin P Hawkes, Jamal M Al Jubeh, Dong Li, Susan E Tucker, Tara Rajiyah, Michael A Levine
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(6): e2449.     CrossRef
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Miscellaneous
Intraoperative Parathyroid Hormone Monitoring in the Surgical Management of Sporadic Primary Hyperparathyroidism
Zahra F. Khan, John I. Lew
Endocrinol Metab. 2019;34(4):327-339.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.327
  • 5,896 View
  • 129 Download
  • 23 Web of Science
  • 24 Crossref
AbstractAbstract PDFPubReader   ePub   

Intraoperative parathyroid hormone monitoring (IPM) has been shown to be a useful adjunct during parathyroidectomy to ensure operative success at many specialized medical centers worldwide. Using the Miami or “>50% intraoperative PTH drop” criterion, IPM confirms the complete excision of all hyperfunctioning parathyroid tissue before the operation is finished, and helps guide the surgeon to identify additional hyperfunctioning parathyroid glands that may necessitate further extensive neck exploration when intraoperative parathyroid hormone (PTH) levels do not drop sufficiently. The intraoperative PTH assay is also used to differentiate parathyroid from non-parathyroid tissues during operations using fine needle aspiration samples and to lateralize the side of the neck harboring the hypersecreting parathyroid through differential jugular venous sampling when preoperative localization studies are negative or equivocal. The use of IPM underscores the recognition and understanding of sporadic primary hyperparathyroidism (SPHPT) as a disease of function rather than form, where the surgeon is better equipped to treat such patients with quantitative instead of qualitative information for durable long-term operative success. There has been a significant paradigm shift over the last 2 decades from conventional to focused parathyroidectomy guided by IPM. This approach has proven to be a safe and rapid operation requiring minimal dissection performed in an ambulatory setting for the treatment of SPHPT.

Citations

Citations to this article as recorded by  
  • Intraoperative parathyroid hormone monitoring in parathyroidectomy for hyperparathyroidism: a protocol for a network meta-analysis of diagnostic test accuracy
    Phillip Staibano, Kevin Um, Sheila Yu, Mohit Bhandari, Michael K. Gupta, Michael Au, JEM (Ted) Young, Han Zhang
    Frontiers in Surgery.2024;[Epub]     CrossRef
  • Primary Hyperparathyroidism
    Saba Kurtom, Sally E. Carty
    Surgical Clinics of North America.2024; 104(4): 799.     CrossRef
  • Characteristics, management and outcomes of primary hyperparathyroidism from 2009 to 2021: a single centre report from South Africa
    Kamal Govind, Imran M. Paruk, Ayesha A. Motala
    BMC Endocrine Disorders.2024;[Epub]     CrossRef
  • Parathyroidectomy for primary hyperparathyroidism: A retrospective analysis of localization, surgical characteristics, and treatment outcomes
    Dongbin Ahn, Ji Hye Kwak, Gil Joon Lee, Jin Ho Sohn
    Asian Journal of Surgery.2023; 46(2): 788.     CrossRef
  • Magnitude of parathyroid hormone elevation in primary hyperparathyroidism: Does time of day matter?
    C. Corbin Frye, Janessa Sullivan, Sai Anusha Sanka, Jingxia Liu, L. Michael Brunt, William Gillanders, Taylor C. Brown, T.K. Pandian
    Surgery.2023; 173(3): 659.     CrossRef
  • Analysis of intraoperative laboratory measurements and imaging techniques such as Tc-99 m-MIBI SPECT/CT, 18F-fluorocholine PET/CT and ultrasound in patients operated with prediagnosis of parathyroid adenoma
    Nurullah Bilen, Mehmet Avni Gokalp, Latif Yilmaz, Alper Aytekin, Ilyas Baskonus
    Irish Journal of Medical Science (1971 -).2023; 192(4): 1695.     CrossRef
  • Intraoperative Parathyroid Hormone Monitoring Is of Limited Usefulness in Guiding Autotransplantation in Reoperative or Subtotal Parathyroidectomy for Primary Hyperparathyroidism
    Bradley A. Richards, Robert A. Vierkant, Benzon M. Dy, Trenton R. Foster, Travis J. McKenzie, Melanie L. Lyden
    The American Surgeon™.2023; 89(12): 5421.     CrossRef
  • Does 18F-Fluorocholine PET/CT add value to positive parathyroid scintigraphy in the presurgical assessment of primary hyperparathyroidism?
    Alessio Imperiale, Jacob Bani, Gianluca Bottoni, Adrien Latgé, Céline Heimburger, Ugo Catrambone, Michel Vix, Giorgio Treglia, Arnoldo Piccardo
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Intraoperative Identification of Thyroid and Parathyroid Tissues During Human Endocrine Surgery Using the MasSpec Pen
    Rachel J. DeHoog, Mary E. King, Michael F. Keating, Jialing Zhang, Marta Sans, Clara L. Feider, Kyana Y. Garza, Alena Bensussan, Anna Krieger, John Q. Lin, Sunil Badal, Elizabeth Alore, Christopher Pirko, Kirtan Brahmbhatt, Wendong Yu, Raymon Grogan, Livi
    JAMA Surgery.2023; 158(10): 1050.     CrossRef
  • A Rare Case of Recurrent Parathyroid Adenomas After Initial Parathyroidectomy
    Grant N Schalet, Luke Vincent, Carl Eguez, Gerardo Diaz, Mark S Shachner
    Cureus.2023;[Epub]     CrossRef
  • Surgical treatment of tertiary hyperparathyroidism: does one fit for all?
    Claudio Casella, Claudio Guarneri, Manuela Campanile, Xavier Adhoute, Pier Paolo Gelera, Riccardo Morandi
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • A >50% Intraoperative Parathyroid Hormone Decrease Into Normal Reference Range Predicts Complete Excision of Malignancy in Patients With Parathyroid Carcinoma
    Valerie L. Armstrong, Tanaz M. Vaghaiwalla, Cima Saghira, Cheng-Bang Chen, Yujie Wang, Johan Anantharaj, Mehmet Ackin, John I. Lew
    Journal of Surgical Research.2023;[Epub]     CrossRef
  • Variation in parathyroid adenoma size in patients with sporadic, primary hyperparathyroidism: small gland size does not preclude single gland disease
    Sophie Dream, Tina W. F. Yen, Kara Doffek, Douglas B. Evans, Tracy S. Wang
    Langenbeck's Archives of Surgery.2022; 407(5): 2067.     CrossRef
  • Role and Recent Trend of Intraoperative Parathyroid Hormone Monitoring During Parathyroidectomy in Patients With Primary Hyperparathyroidism
    Dongbin Ahn, Ji Hye Kwak
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2022; 65(5): 253.     CrossRef
  • Parathyroid Adenoma: Rare Cause of Acute Recurrent Pancreatitis
    Shikha Mahajan, Alka Kumar, Vivek Aggarwal, Vikas Jain, Vipul Baweja, Ajay Ajmani, Diplomate CBNC, Fellow EBNM LNU
    Annals of Pediatric Gastroenterology and Hepatology.2022; 2(3-4): 9.     CrossRef
  • Long-term outcome of surgical techniques for sporadic primary hyperparathyroidism in a tertiary referral center in Belgium
    Klaas Van Den Heede, Amélie Bonheure, Nele Brusselaers, Sam Van Slycke
    Langenbeck's Archives of Surgery.2022; 407(7): 3045.     CrossRef
  • Contribution of intraoperative parathyroid hormone monitoring to the surgical success in minimal invasive parathyroidectomy
    Ismail Ethem Akgün, Mehmet Taner Ünlü, Nurcihan Aygun, Mehmet Kostek, Mehmet Uludag
    Frontiers in Surgery.2022;[Epub]     CrossRef
  • Surgery for primary hyperparathyroidism
    Murilo Catafesta das Neves, Rodrigo Oliveira Santos, Monique Nakayama Ohe
    Archives of Endocrinology and Metabolism.2022; 66(5): 678.     CrossRef
  • Використання інтраопераційного моніторингу рівня паратиреоїдного гормону в мінімально інвазивній хірургії щитоподібної та паращитоподібних залоз
    S.V. Chernyshov, A.V. Tymkiv, A.V. Vovkanych, I.I. Komisarenko
    Endokrynologia.2022; 27(4): 311.     CrossRef
  • Diagnostic Values of Intraoperative (1-84) Parathyroid Hormone Levels are Superior to Intact Parathyroid Hormone for Successful Parathyroidectomy in Patients With Chronic Kidney Disease
    Fangyan Xu, Yaoyu Huang, Ming Zeng, Lina Zhang, Wenkai Ren, Hanyang Qian, Ying Cui, Guang Yang, Wenbin Zhou, Shui Wang, Hui Huang, Huimin Chen, Yujie Xiao, Xueyan Gao, Zhanhui Gao, Jing Wang, Cuiping Liu, Jing Zhang, Baiqiao Zhao, Anning Bian, Fan Li, Hui
    Endocrine Practice.2021; 27(11): 1065.     CrossRef
  • Delayed Calcium Normalization after Successful Parathyroidectomy in Primary Hyperparathyroidism
    Iván Emilio de la Cruz Rodríguez, Elsy Sarahí García Montesinos, María Fernanda Rodríguez-Delgado, Guadalupe Vargas Ortega, Lourdes Balcázar Hernández, Victoria Mendoza Zubieta, Victor Hernández Avendaño, Baldomero González Virla, Micha�l R. Laurent
    Case Reports in Endocrinology.2021; 2021: 1.     CrossRef
  • Parathyroid Surgery
    Aditya S. Shirali, Uriel Clemente-Gutierrez, Nancy D. Perrier
    Neuroimaging Clinics of North America.2021; 31(3): 397.     CrossRef
  • Focused parathyroidectomy without intraoperative parathyroid hormone measurement in primary hyperparathyroidism: Still a valid approach?
    Shelby Holt
    Surgery.2021; 170(6): 1860.     CrossRef
  • Response to the Comment on “Risk Factors of Redo Surgery After Unilateral Focused Parathyroidectomy – Conclusions From a Comprehensive Nationwide Database of 13,247 Interventions Over 6 Years”
    Robert Caiazzo, Camille Marciniak, Francois Pattou
    Annals of Surgery.2021; 274(6): e861.     CrossRef
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