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5 "Pancytopenia"
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Case Reports
Pancytopenia Associated with Hypopituitarism in an Acromegaly Patient: A Case Report and a Review of the Literature.
Jung Hee Koh, Yong Jae Lee, Ji Hyun Kang, Bo Kwang Choi, Yun Kyung Jeon, Sang Soo Kim, Bo Hyun Kim, In Joo Kim
Endocrinol Metab. 2012;27(4):308-313.   Published online December 20, 2012
DOI: https://doi.org/10.3803/EnM.2012.27.4.308
  • 2,553 View
  • 29 Download
  • 2 Crossref
AbstractAbstract PDF
We present the case of a patient with acromegaly who had pancytopenia with hypopituitarism secondary to the excision of a pituitary macroadenoma and radiation therapy. A 28-year-old man presented with pancytopenia and serum electrolyte abnormalities. He was diagnosed with acromegaly and underwent surgery and gamma-knife radiotherapy for a pituitary macroadenoma at the age of 22 years. A recent brain magnetic resonance imaging showed an empty sella, and the basal hormonal profile demonstrated deficiencies of pituitary hormones except thyrotropin. As presenting pancytopenia, his bone marrow biopsy showed hypocellular marrow. The total number of hemocytes increased after hydrocortisone replacement. Hypopituitarism was a possible cause of pancytopenia, and glucocorticoids had crucial effects on converting pancytopenia to normal in this case.

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  • A 24-Year-Old Male with Gigantism, Growth Hormone Deficiency, Suspected Clivus Chordoma, Primary Hypothyroidism, Hypogonadism and Pancytopenia
    W.A. Arsana, M.I. Diah Pramudianti
    INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY.2019; 26(2): 249.     CrossRef
  • Hormones and the Bone Marrow: Panhypopituitarism and Pancytopenia in a Man with a Pituitary Adenoma
    Dianna Lang, Jennifer S. Mead, David B. Sykes
    Journal of General Internal Medicine.2015; 30(5): 692.     CrossRef
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A Case of Sheehan's Syndrome with Pancytopenia.
Hyun Suk Lee, Byung Woon Kwon, Jin Hyung Han, Hee Jin Kim
Endocrinol Metab. 2012;27(1):54-58.   Published online March 1, 2012
DOI: https://doi.org/10.3803/EnM.2012.27.1.54
  • 2,874 View
  • 24 Download
AbstractAbstract PDF
Sheehan's syndrome is characterized by varying degrees of anterior pituitary dysfunction due to postpartum ischemic necrosis of the pituitary gland after massive bleeding. The spectrum of clinical presentation of Sheehan's syndrome is broad, with changes from nonspecific complaints, such as weakness, fatigue, and anemia, to severe pituitary insufficiency resulting in coma and death. Normochromic anemia is commonly associated with Sheehan's syndrome, but pancytopenia is rarely observed in patients with Sheehan's syndrome. We describe a 57-year-old woman with Sheehan's syndrome who presented with pancytopenia that was treated by hormone replacement with levothyroxine and glucocorticoid.
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A Case of Graves' Disease with Pancytopenia.
Jong Ho Shin, Hyun Jin Kim, Si Bum Kim, Dong Pil Kim, Bong Suk Ko, Dong Soon Kim, Ji Myung Kim, Soo Jung Gong, Jung Ae Lee
J Korean Endocr Soc. 2009;24(4):272-276.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.272
  • 2,395 View
  • 32 Download
  • 3 Crossref
AbstractAbstract PDF
Hematological disorders, and especially single lineage abnormalities, have been described in patients suffering with thyrotoxicosis, but pancytopenia is a rare complication of thyrotoxicosis. Pancytopenia with thyrotoxicosis has been reported to be totally reversible with antithyroid drug treatment. We experienced a case with pancytopenia associated with Graves' disease in a 57-year-old woman who had no specific cause of pancytopenia. She presented with dyspnea and palpitation. The laboratory findings revealed thyrotoxicosis and pancytopenia. Increased radioisotope uptake was seen on the thyroid scan and normal cellularity and maturation were found in the bone marrow aspiration biopsy. Based on these findings, she was diagnosed as suffering from Gravesyendisease with pancytopenia. After treatment with propylthiouracil, the blood cell counts were restored to normal as the patient achieved a euthyroid state. We report here on a case of Graves' disease that was complicated by pancytopenia, and all this was normalized after treatment for hyperthyroidism.

Citations

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  • Non-myeloproliferative Pancytopenia: A Rare Presentation of Thyrotoxicosis
    Izzathunnisa Rahmathullah, Maheswaran Umakanth, Suranga Singhapathirane
    Cureus.2023;[Epub]     CrossRef
  • Pancytopenia in a surgical patient, a rare presentation of hyperthyroidism
    Prabhat Jha, Yogendra Prasad Singh, Bikal Ghimire, Binit Kumar Jha
    BMC Surgery.2014;[Epub]     CrossRef
  • A Case of Pancytopenia with Hyperthyroidism
    Tae Hoon Kim, Ji Sung Yoon, Byung Sam Park, Dong Won Lee, Jae Ho Cho, Jun Sung Moon, Eui Hyun Kim, Kyu Chang Won, Hyoung Woo Lee
    Yeungnam University Journal of Medicine.2013; 30(1): 47.     CrossRef
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A Case of Methimazole-induced Pancytopenia: Successful Treatment with Recombinant Human Granulocyte Colony-stimulating Factor.
Joo Hyoung Lee, Jihyun Lee, Sang Hun Sung, Sung Hwa Bae, Sang Gyung Kim, Hoon Kyu Oh
J Korean Endocr Soc. 2006;21(6):548-551.   Published online December 1, 2006
DOI: https://doi.org/10.3803/jkes.2006.21.6.548
  • 2,235 View
  • 27 Download
  • 1 Crossref
AbstractAbstract PDF
Methimazole has remained the cornerstone for the treatment of hyperthyroidism since 1940's and it is a well-tolerated antithyroid drug. Pancytopenia is one of the major side effects of methimazole, but its occurrence is very rare. There have been some case reports about methimazole-induced pancytopenia that was treated with recombinant human granulocyte colony-stimulating factor (G-CSF), but its usefulness is still controversial. We present here a case of a 50-year-old female who had been treated with methimazole for hyperthyroidism and she subsequently presented pancytopenia. G-CSF was given for 10 days and she successfully recovered from the pancytopenia.

Citations

Citations to this article as recorded by  
  • A Case of Graves' Disease with Pancytopenia
    Jong Ho Shin, Hyun Jin Kim, Si Bum Kim, Dong Pil Kim, Bong Suk Ko, Dong Soon Kim, Ji Myung Kim, Soo Jung Gong, Jung-Ae Lee
    Journal of Korean Endocrine Society.2009; 24(4): 272.     CrossRef
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A Case of Pancytopenia Caused by Sheehan's Syndorme Improved with Hormone Replacement Therapy.
Sung Ki Kim, Yoon Ju Oh, Park Young Joo, Young Whan Kim, Seong Bin Hong, Mi Rim Kim, Moon Suk Nam, Yong Seong Kim
J Korean Endocr Soc. 2000;15(4-5):595-599.   Published online January 1, 2001
  • 1,108 View
  • 19 Download
AbstractAbstract PDF
Postpartum ischemic necrosis of the pituitary gland, known as Sheehan's syndrome, is well- established clinical entity. In anterior pituitary insufficiency, there is very often a normochromic or hypochromic anemia but pancytopenia secondary to the hypopituitarism is less common. We report a case of pancytopenia due to complete aplasia of the bone marrow associated with Sheehan's syndrome, in which hormone replacement therapy alone produced full hematological recovery.
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