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Case Report
- Two Cases of hypoglycemia in IDDM patients with insulin antibody.
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G A Kim, K W Lee, M R Kim, Y J Kim, J N Jang, S K Bae, B G Son
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J Korean Endocr Soc. 1996;11(2):240-246. Published online November 7, 2019
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Abstract
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- Hirata et al. first described the association of insulin antibodies with hypoglycemia attacks and decreased glucose tolerance in a patient who had not previously received insulin injections. Since that time there have been additional reports in the Japanese literature. Insulin antibodies are present in most of the patients who received insulin for a period of time, usually exceeding six weeks. There were several reports of hypoglycemia in patients with non-insulin-dependent diabetes mellitus who had developed insulin antibody after insulin administration and also in patients with insulin dependent diabetes mellitus. It is well known that either insulin antibody to the lower affinity site or insulin receptor antibody can be a eause of hypoglycemia. Recently, we experienced two cases of hypoglycemia in patient with insulin dependent diabetes rnellitus and non- insulin- dependent diabetes mellitus who had developed insulin antibody after insulin administration. Hereby we present these cases with review of the literature.
Original Article
- Quantitative Changes of Apoprotein Levels in Non - Insulin Dependent Diabetics.
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Do Young Kang, Duk Kyu Kim
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J Korean Endocr Soc. 1994;10(2):105-114. Published online November 6, 2019
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Abstract
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- The aim of this study was to evaluate the quantitative changes of apoprotein levels in non-insulin dependent diabetics.As the subjects of this study, 37 patients were selected among non-insulin dependent diabetics admitted to Dong-A University Hospital between March 1990 and February 1994. They were divided into two groups. One group(n=20) had the diabetic dyslipidemia(Group DD) and the other group(n=17) had no diabetic dyslipidemia(Group D). For the control, normal healthy persons(n=17) were studied.Plasma lipid and apoprotein levels of all the subjects were measured. The results were as follows;1) Apoprotein AI & AII levels were significantly decreased in Group DD compared with both Group D and Control, but there was no significant difference between Group D and Control.2) Apoprotein B levels were significantly decreased in both Group DD and Group D compared with Control, but there was no significant difference between Group DD and Group D. 3) Apoprotein CII levels were significantly increased in both Group DD and Group D compared with Control, but there was no significant difference between Group DD and Group D. 4) Apoprotein CIII levels were significantly increased in Group D compared with both Group DD and Control, but there was no significant difference between Group DD and Control. 5) Apoprotein E levels were not significantly different among three groups.These results suggest that NIDDM itself causes the level of apoprotein B to decrease and the level of apoprotein CII to increase, regardless of the associated diabetic dyslipidemia.
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