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Calcium & bone metabolism
Higher Plasma Stromal Cell-Derived Factor 1 Is Associated with Lower Risk for Sarcopenia in Older Asian Adults
Sunghwan Ji, Kyunggon Kim, So Jeong Park, Jin Young Lee, Hee-Won Jung, Hyun Ju Yoo, Il-Young Jang, Eunju Lee, Ji Yeon Baek, Beom-Jun Kim
Endocrinol Metab. 2023;38(6):701-708.   Published online October 18, 2023
DOI: https://doi.org/10.3803/EnM.2023.1783
  • 1,510 View
  • 73 Download
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Despite the protective effects of stromal cell-derived factor 1 (SDF-1) in stimulating muscle regeneration shown in experimental research, there is a lack of clinical studies linking circulating SDF-1 concentrations with muscle phenotypes. In order to elucidate the role of SDF-1 as a potential biomarker reflecting human muscle health, we investigated the association of plasma SDF-1 levels with sarcopenia in older adults.
Methods
This cross-sectional study included 97 community-dwelling participants who underwent a comprehensive geriatric assessment at a tertiary hospital in South Korea. Sarcopenia was defined by specific cutoff values applicable to the Asian population, whereas plasma SDF-1 levels were determined using an enzyme immunoassay.
Results
After accounting for sex, age, and body mass index, participants with sarcopenia and low muscle mass exhibited plasma SDF-1 levels that were 21.8% and 18.3% lower than those without these conditions, respectively (P=0.008 and P=0.009, respectively). Consistently, higher plasma SDF-1 levels exhibited a significant correlation with higher skeletal muscle mass index (SMI) and gait speed (both P=0.043), and the risk of sarcopenia and low muscle mass decreased by 58% and 55% per standard deviation increase in plasma SDF-1 levels, respectively (P=0.045 and P=0.030, respectively). Furthermore, participants in the highest SDF-1 tertile exhibited significantly higher SMI compared to those in the lowest tertile (P=0.012).
Conclusion
These findings clinically corroborate earlier experimental discoveries highlighting the muscle anabolic effects of SDF- 1 and support the potential role of circulating SDF-1 as a biomarker reflecting human muscle health in older adults.
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Calcium & Bone Metabolism
Decreased Serum Level of Sclerostin in Older Adults with Sarcopenia
Seong Hee Ahn, Hee-Won Jung, Eunju Lee, Ji Yeon Baek, Il-Young Jang, So Jeong Park, Jin Young Lee, Eunah Choi, Yun Sun Lee, Seongbin Hong, Beom-Jun Kim
Endocrinol Metab. 2022;37(3):487-496.   Published online May 27, 2022
DOI: https://doi.org/10.3803/EnM.2022.1428
  • 3,016 View
  • 138 Download
  • 11 Web of Science
  • 9 Crossref
AbstractAbstract PDFPubReader   ePub   
Background
Although muscles and bones interact with each other through various secretory factors, the role of sclerostin, an osteocyte-secreted factor, on muscle metabolism has not been well studied. We investigated the levels of serum sclerostin in Korean older adults with sarcopenia.
Methods
Blood samples were collected from 129 participants who underwent evaluation of muscle mass and function in an outpatient geriatric clinic of a teaching hospital. Sarcopenia and related parameters were determined using cutoff values for the Asian population. Serum sclerostin levels were measured using an enzyme-linked immunosorbent assay.
Results
The mean age of the participants was 69.6 years, and 20 participants (15.5%) were classified as having sarcopenia. After adjusting for age, sex, and body mass index, serum sclerostin levels were significantly lower in participants with sarcopenia, low muscle mass, or weak muscle strength (P=0.003 to 0.045). Serum sclerostin levels were positively associated with skeletal muscle index and grip strength after adjusting for confounders (P=0.001 and P=0.003), whereas sarcopenic phenotype score showed a negative association (P=0.006). These increases in muscle mass and strength were also dose dependent as serum sclerostin levels increased (P for trends=0.003 and P for trends=0.015). Higher serum sclerostin levels were associated with lower odds ratio (ORs) for sarcopenia, low muscle mass, and weak muscle strength after adjusting for confounders (OR, 0.27 to 0.50; P<0.001 to 0.025).
Conclusion
Higher serum sclerostin levels were associated with a lower risk of sarcopenia, low muscle mass, and weak muscle strength in Korean older adults.

Citations

Citations to this article as recorded by  
  • Mechanism and physical activities in bone-skeletal muscle crosstalk
    Zhonghan Zhao, Kai Yan, Qiao Guan, Qiang Guo, Can Zhao
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Determinants of bone mass in older adults with normal- and overweight derived from the crosstalk with muscle and adipose tissue
    Carina O. Walowski, Catrin Herpich, Janna Enderle, Wiebke Braun, Marcus Both, Mario Hasler, Manfred J. Müller, Kristina Norman, Anja Bosy-Westphal
    Scientific Reports.2023;[Epub]     CrossRef
  • Role of the Osteocyte in Musculoskeletal Disease
    Anika Shimonty, Lynda F. Bonewald, Fabrizio Pin
    Current Osteoporosis Reports.2023; 21(3): 303.     CrossRef
  • The role of sclerostin in lipid and glucose metabolism disorders
    Hewen Jiang, Dijie Li, Ying Han, Nanxi Li, Xiaohui Tao, Jin Liu, Zongkang Zhang, Yuanyuan Yu, Luyao Wang, Sifan Yu, Ning Zhang, Huan Xiao, Xin Yang, Yihao Zhang, Ge Zhang, Bao-Ting Zhang
    Biochemical Pharmacology.2023; 215: 115694.     CrossRef
  • Cytokines and exosomal miRNAs in skeletal muscle–adipose crosstalk
    Liu Guo, Menchus Quan, Weijun Pang, Yulong Yin, Fengna Li
    Trends in Endocrinology & Metabolism.2023; 34(10): 666.     CrossRef
  • Sclerostin: clinical insights in muscle–bone crosstalk
    Antimo Moretti, Giovanni Iolascon
    Journal of International Medical Research.2023;[Epub]     CrossRef
  • Anti-sclerostin antibodies: a new frontier in fragility fractures treatment
    Giovanni Iolascon, Sara Liguori, Marco Paoletta, Giuseppe Toro, Antimo Moretti
    Therapeutic Advances in Musculoskeletal Disease.2023;[Epub]     CrossRef
  • Sclerostin as a Putative Myokine in Sarcopenia
    Hyon-Seung Yi
    Endocrinology and Metabolism.2022; 37(3): 430.     CrossRef
  • Organokines, Sarcopenia, and Metabolic Repercussions: The Vicious Cycle and the Interplay with Exercise
    Giulia Minniti, Letícia Maria Pescinini-Salzedas, Guilherme Almeida dos Santos Minniti, Lucas Fornari Laurindo, Sandra Maria Barbalho, Renata Vargas Sinatora, Lance Alan Sloan, Rafael Santos de Argollo Haber, Adriano Cressoni Araújo, Karina Quesada, Jesse
    International Journal of Molecular Sciences.2022; 23(21): 13452.     CrossRef
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Obesity and Metabolism
Variation in Serum Creatinine Level Is Correlated to Risk of Type 2 Diabetes
Jun Sung Moon, Ji Eun Lee, Ji Sung Yoon
Endocrinol Metab. 2013;28(3):207-213.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.207
  • 4,014 View
  • 46 Download
  • 19 Crossref
AbstractAbstract PDFPubReader   
Background

Skeletal muscle is well established as a major target organ of insulin action, and is associated with the pathogenesis of type 2 diabetes. Therefore, we attempted to determine whether a variation in serum creatinine is related to the development of type 2 diabetes and other risk factors for diabetes.

Methods

A total of 2,676 nondiabetic subjects with stable and normal renal function (estimated glomerular filtration rate >60 mL/min/1.73 m2) were followed up for approximately 4.5 years. New onset diabetes was defined as fasting plasma glucose (FPG) ≥7.0 mmol/L, glycated hemoglobin (HbA1c) ≥6.5%, or subjects taking antidiabetic agents. Variation of serum creatinine (ΔCre) was defined as a difference between follow-up and baseline creatinine. In subgroup analysis, body composition was examined by bioelectric impedance analysis method.

Results

A total of 106 subjects were diagnosed with new-onset diabetes during the follow-up period. Baseline serum creatinine was not different between the new-onset diabetes and no diabetes groups. Negative ΔCre (ΔCre <0) showed an association with increased risk of type 2 diabetes after adjusting for age, sex, body mass index, systolic blood pressure, FPG, HbA1c, triglyceride, high density lipoprotein cholesterol, and γ-glutamyl transpeptidase (odds ratio, 1.885; 95% confidence interval, 1.127 to 3.153). Serum creatinine level demonstrated positive correlation with muscle mass and negative correlation with percentage of body fat in body composition analysis.

Conclusion

Serum creatinine reflected body muscle mass and the decrease of serum creatinine might be regarded as a risk factor for type 2 diabetes.

Citations

Citations to this article as recorded by  
  • Low serum creatinine, a surrogate marker of muscle mass, correlates with insulin sensitivity in nonhuman primates
    Uddhav K. Chaudhari, Barbara C. Hansen
    Journal of Medical Primatology.2023; 52(2): 100.     CrossRef
  • Identification of Novel Biomarkers of Spinal Muscular Atrophy and Therapeutic Response by Proteomic and Metabolomic Profiling of Human Biological Fluid Samples
    Megi Meneri, Elena Abati, Delia Gagliardi, Irene Faravelli, Valeria Parente, Antonia Ratti, Federico Verde, Nicola Ticozzi, Giacomo P. Comi, Linda Ottoboni, Stefania Corti
    Biomedicines.2023; 11(5): 1254.     CrossRef
  • Association of serum creatinine levels and risk of type 2 diabetes mellitus in Korea: a case control study
    Do Kyeong Song, Young Sun Hong, Yeon-Ah Sung, Hyejin Lee
    BMC Endocrine Disorders.2022;[Epub]     CrossRef
  • Impact of Female Sex on the Susceptibility to Hypernatremia Among Older Community-Dwelling Individuals in Japan
    Sho Tanaka, Midori Fujishiro, Kazuhiro Imatake, Yasuyuki Suzuki, Hisamitsu Ishihara, Shigemasa Tani
    International Journal of General Medicine.2022; Volume 15: 777.     CrossRef
  • Ameliorative Effect of Oxytocin on FBN1 and PEPCK Gene Expression, and Behavioral Patterns in Rats' Obesity-Induced Diabetes
    Asmaa Elnagar, Khalifa El-Dawy, Hussein I. El-Belbasi, Ibrahim F. Rehan, Hamdy Embark, Zeinab Al-Amgad, Obeid Shanab, Elsayed Mickdam, Gaber E. Batiha, Salman Alamery, Samer S. Fouad, Simona Cavalu, Mohammed Youssef
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Time to doubling of serum creatinine in patients with diabetes in Ethiopian University Hospital: Retrospective follow-up study
    Adeladlew Kassie Netere, Ashenafi Kibret Sendekie, Donovan Anthony McGrowder
    PLOS ONE.2022; 17(9): e0274495.     CrossRef
  • Deep Learning for Integrated Analysis of Insulin Resistance with Multi-Omics Data
    Eunchong Huang, Sarah Kim, TaeJin Ahn
    Journal of Personalized Medicine.2021; 11(2): 128.     CrossRef
  • Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction
    Md. Khalequzzaman Sarker, Selim Reza Tony, Abu Eabrahim Siddique, Md. Rezaul Karim, Nazmul Haque, Zohurul Islam, Md. Shofikul Islam, Moriom Khatun, Jahidul Islam, Shakhawoat Hossain, Zahangir Alam Saud, Hideki Miyataka, Daigo Sumi, Aaron Barchowsky, Seiic
    International Journal of Environmental Research and Public Health.2021; 18(18): 9730.     CrossRef
  • Creatinine to Body Weight Ratio Is Associated with Incident Diabetes: Population-Based Cohort Study
    Yoshitaka Hashimoto, Takuro Okamura, Masahide Hamaguchi, Akihiro Obora, Takao Kojima, Michiaki Fukui
    Journal of Clinical Medicine.2020; 9(1): 227.     CrossRef
  • ¿Debemos prestar más atención a la creatinina baja?
    Carlos A. Amado Diago, José A. Amado Señaris
    Endocrinología, Diabetes y Nutrición.2020; 67(7): 486.     CrossRef
  • Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass
    Victor Mondal, Zubaer Hosen, Faruk Hossen, Abu Eabrahim Siddique, Selim Reza Tony, Zohurul Islam, Md. Shofikul Islam, Shakhawoat Hossain, Khairul Islam, Md. Khalequzzaman Sarker, M.M. Hasibuzzaman, Ling-Zhi Liu, Bing-Hua Jiang, Md Mominul Hoque, Zahangir
    Environment International.2020; 143: 105890.     CrossRef
  • Noninvasive assessment of abdominal adipose tissues and quantification of hepatic and pancreatic fat fractions in type 2 diabetes mellitus
    Manoj Kumar Sarma, Andres Saucedo, Christine Hema Darwin, Ely Richard Felker, Kavya Umachandran, Daniel Kohanghadosh, Edward Xu, Steve Raman, Michael Albert Thomas
    Magnetic Resonance Imaging.2020; 72: 95.     CrossRef
  • Should we pay more attention to low creatinine levels?
    Carlos A. Amado Diago, José A. Amado Señaris
    Endocrinología, Diabetes y Nutrición (English ed.).2020; 67(7): 486.     CrossRef
  • Acute Effect of the Timing of Resistance Exercise and Nutrient Intake on Muscle Protein Breakdown
    Wataru Kume, Jun Yasuda, Takeshi Hashimoto
    Nutrients.2020; 12(4): 1177.     CrossRef
  • Serum creatinine levels and risk of incident type 2 diabetes mellitus or dysglycemia in middle-aged Japanese men: a retrospective cohort study
    Mamoru Takeuchi, Hironori Imano, Isao Muraki, Yuji Shimizu, Mina Hayama-Terada, Akihiko Kitamura, Takeo Okada, Masahiko Kiyama, Hiroyasu Iso
    BMJ Open Diabetes Research & Care.2018; 6(1): e000492.     CrossRef
  • Assessment of kidney dysfunction with cystatin C- and creatinine-based estimated glomerular filtration rate and predicting type 2 diabetes: Toranomon Hospital Health Management Center Study 21
    Yoriko Heianza, Shigeko Hara, Kazumi Saito, Hiroshi Tsuji, Shiro Tanaka, Satoru Kodama, Tetsuro Kobayashi, Yasuji Arase, Hirohito Sone
    Diabetes Research and Clinical Practice.2016; 113: 60.     CrossRef
  • Profiling human blood serum metabolites by nuclear magnetic resonance spectroscopy: a comprehensive tool for the evaluation of hemodialysis efficiency
    Marika Kromke, Martina Palomino-Schätzlein, Horst Mayer, Stefan Pfeffer, Antonio Pineda-Lucena, Burkhard Luy, Martin Hausberg, Claudia Muhle-Goll
    Translational Research.2016; 171: 71.     CrossRef
  • Safety evaluation of the consumption of high dose milk fat globule membrane in healthy adults: a double-blind, randomized controlled trial with parallel group design
    Sayaka Hari, Ryuji Ochiai, Yasushi Shioya, Yoshihisa Katsuragi
    Bioscience, Biotechnology, and Biochemistry.2015; 79(7): 1172.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
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