Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
9 "Hypothalamus"
Filter
Filter
Article type
Keywords
Publication year
Authors
Funded articles
Namgok Lecture 2023
Diabetes, obesity and metabolism
Hypothalamic AMP-Activated Protein Kinase as a Whole-Body Energy Sensor and Regulator
Se Hee Min, Do Kyeong Song, Chan Hee Lee, Eun Roh, Min-Seon Kim
Endocrinol Metab. 2024;39(1):1-11.   Published online February 14, 2024
DOI: https://doi.org/10.3803/EnM.2024.1922
  • 1,486 View
  • 45 Download
AbstractAbstract PDFPubReader   ePub   
5´-Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a cellular energy sensor, is an essential enzyme that helps cells maintain stable energy levels during metabolic stress. The hypothalamus is pivotal in regulating energy balance within the body. Certain neurons in the hypothalamus are sensitive to fluctuations in food availability and energy stores, triggering adaptive responses to preserve systemic energy equilibrium. AMPK, expressed in these hypothalamic neurons, is instrumental in these regulatory processes. Hypothalamic AMPK activity is modulated by key metabolic hormones. Anorexigenic hormones, including leptin, insulin, and glucagon-like peptide 1, suppress hypothalamic AMPK activity, whereas the hunger hormone ghrelin activates it. These hormonal influences on hypothalamic AMPK activity are central to their roles in controlling food consumption and energy expenditure. Additionally, hypothalamic AMPK activity responds to variations in glucose concentrations. It becomes active during hypoglycemia but is deactivated when glucose is introduced directly into the hypothalamus. These shifts in AMPK activity within hypothalamic neurons are critical for maintaining glucose balance. Considering the vital function of hypothalamic AMPK in the regulation of overall energy and glucose balance, developing chemical agents that target the hypothalamus to modulate AMPK activity presents a promising therapeutic approach for metabolic conditions such as obesity and type 2 diabetes mellitus.
Close layer
Review Articles
Obesity and Metabolism
Dopaminergic Control of the Feeding Circuit
Ja-Hyun Baik
Endocrinol Metab. 2021;36(2):229-239.   Published online April 6, 2021
DOI: https://doi.org/10.3803/EnM.2021.979
  • 8,869 View
  • 460 Download
  • 11 Web of Science
  • 13 Crossref
AbstractAbstract PDFPubReader   ePub   
There is increasing evidence demonstrating that reward-related motivational food intake is closely connected with the brain’s homeostatic system of energy balance and that this interaction might be important in the integrative control of feeding behavior. Dopamine regulates motivational behavior, including feeding behaviors, and the dopamine reward system is recognized as the most prominent system that controls appetite and motivational and emotional drives for food. It appears that the dopamine system exerts a critical role in the control of feeding behavior not only by the reward-related circuit, but also by contributing to the homeostatic circuit of food intake, suggesting that dopamine plays an integrative role across the converging circuitry of control of food intake by linking energy state-associated signals to reward-related behaviors. This review will cover and discuss up-to-date findings on the dopaminergic control of food intake by both the reward-related circuit and the homeostatic hypothalamic system.

Citations

Citations to this article as recorded by  
  • Cross-cultural adaptation and psychometric investigation of the palatable eating motives scale (PEMS) for a sample of Brazilian adults
    Priscila Carvalho Santos, Wanderson Roberto da Silva, João Marôco, Juliana Alvares Duarte Bonini Campos
    Current Psychology.2024; 43(7): 6360.     CrossRef
  • The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish
    Margherita Zaupa, Nagarjuna Nagaraj, Anna Sylenko, Herwig Baier, Suphansa Sawamiphak, Alessandro Filosa
    Neuron.2024;[Epub]     CrossRef
  • Maternal nanoplastic ingestion induces an increase in offspring body weight through altered lipid species and microbiota
    Bohyeon Jeong, Ji-Sun Kim, A Ra Kwon, Jangjae Lee, Subin Park, Jahong Koo, Wang Sik Lee, Jeong Yeob Baek, Won-Ho Shin, Jung-Sook Lee, Jinyoung Jeong, Won Kon Kim, Cho-Rok Jung, Nam-Soon Kim, Sung-Hee Cho, Da Yong Lee
    Environment International.2024; 185: 108522.     CrossRef
  • Satiety: a gut–brain–relationship
    Ghinwa M. Barakat, Wiam Ramadan, Ghaith Assi, Noura B. El Khoury
    The Journal of Physiological Sciences.2024;[Epub]     CrossRef
  • Effect of Probiotic Lacticaseibacillus rhamnosus LB1.5 on Anxiety-like Behavior, Neuroprotection and Neuroinflammation Markers of Male Mice Fed a High-Fat Diet
    Natália Perin Schmidt, Patrícia Molz, Brenda Santos Fraga, Nicole Hiller Bondarczuk, Priscila Dutra Silveira, Milena Henrique Ferri, Thais Busatto Crestani, Gabriela Merker Breyer, Giuliano Rizzoto Guimarães, Amanda de Souza da Motta, Renata Padilha Guede
    Nutrients.2024; 16(6): 879.     CrossRef
  • Retracted : Pan‐neuronal knockdown of Ras GTPase‐activating protein 1 alters Drosophila activity and sleep behavior
    Francisco Alejandro Lagunas‐Rangel
    Archives of Insect Biochemistry and Physiology.2023;[Epub]     CrossRef
  • Maternal Over- and Malnutrition and Increased Risk for Addictive and Eating Disorders in the Offspring
    Mathilde C. C. Guillaumin, Daria Peleg-Raibstein
    Nutrients.2023; 15(5): 1095.     CrossRef
  • Carving the senescent phenotype by the chemical reactivity of catecholamines: An integrative review
    Aleksei G. Golubev
    Ageing Research Reviews.2022; 75: 101570.     CrossRef
  • Obesity I: Overview and molecular and biochemical mechanisms
    Robert H. Lustig, David Collier, Christopher Kassotis, Troy A. Roepke, Min Ji Kim, Etienne Blanc, Robert Barouki, Amita Bansal, Matthew C. Cave, Saurabh Chatterjee, Mahua Choudhury, Michael Gilbertson, Dominique Lagadic-Gossmann, Sarah Howard, Lars Lind,
    Biochemical Pharmacology.2022; 199: 115012.     CrossRef
  • Food preferences and thyroid hormones in children and adolescents with obesity
    Daniela Staníková, Lea Krajčovičová, Linda Demková, Petronela Forišek-Paulová, Lucia Slobodová, Eva Vitariušová, Lubica Tichá, Barbara Ukropcová, Juraj Staník, Jozef Ukropec
    Frontiers in Psychiatry.2022;[Epub]     CrossRef
  • Dopamine systems and biological rhythms: Let’s get a move on
    Qijun Tang, Dina R. Assali, Ali D. Güler, Andrew D. Steele
    Frontiers in Integrative Neuroscience.2022;[Epub]     CrossRef
  • Suprachiasmatic to paraventricular nuclei interaction generates normal food searching rhythms in mice
    Iwona Olejniczak, Benjamin Campbell, Yuan-Chen Tsai, Shiva K. Tyagarajan, Urs Albrecht, Jürgen A. Ripperger
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • THE ROLE OF CIRCADIAN REGULATION OF GHRELIN LEVELS IN PARKINSON’S DISEASE (LITERATURE REVIEW)
    Kateryna A. Tarianyk, Nataliya V. Lytvynenko, Anastasiia D. Shkodina, Igor P. Kaidashev
    Wiadomości Lekarskie.2021; 74(7): 1750.     CrossRef
Close layer
Obesity and Metabolism
Brain Regulation of Energy Metabolism
Eun Roh, Min-Seon Kim
Endocrinol Metab. 2016;31(4):519-524.   Published online December 20, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.4.519
  • 9,657 View
  • 175 Download
  • 52 Web of Science
  • 52 Crossref
AbstractAbstract PDFPubReader   

In healthy individuals, energy intake is in balance with energy expenditure, which helps to maintain a normal body weight. The brain's inability to control energy homeostasis underlies the pathology of hyperphagia and obesity. The brain detects body energy excess and deficit by sensing the levels of circulating metabolic hormones and nutrients and by receiving metabolic information from the periphery via the autonomic nervous system. A specialized neuronal network coordinates energy intake behavior and the metabolic processes affecting energy expenditure. Here, we briefly review neuronal mechanisms by which our body maintains energy balance.

Citations

Citations to this article as recorded by  
  • Hypothalamic AMP-Activated Protein Kinase as a Whole-Body Energy Sensor and Regulator
    Se Hee Min, Do Kyeong Song, Chan Hee Lee, Eun Roh, Min-Seon Kim
    Endocrinology and Metabolism.2024; 39(1): 1.     CrossRef
  • Adipokines from white adipose tissue in regulation of whole body energy homeostasis
    Bijayashree Sahu, Naresh C. Bal
    Biochimie.2023; 204: 92.     CrossRef
  • Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in a sex-specific manner
    Lukas Stilgenbauer, Juliana Bezerra Medeiros de Lima, Lucas Kniess Debarba, Manal Khan, Lisa Koshko, John J. Kopchick, Andrzej Bartke, Augusto Schneider, Marianna Sadagurski
    GeroScience.2023; 45(3): 1745.     CrossRef
  • Living high - training low model applied to C57BL/6J mice: Effects on physiological parameters related to aerobic fitness and acid-base balance
    Pedro Paulo Menezes Scariot, Marcelo Papoti, Emanuel Elias Camolese Polisel, Juan Bordon Orsi, Paul R. Van Ginkel, Tomas A. Prolla, Fúlvia Barros Manchado-Gobatto, Claudio Alexandre Gobatto
    Life Sciences.2023; 317: 121443.     CrossRef
  • Whole Transcriptome Analysis of Hypothalamus in Mice during Short-Term Starvation
    Eun-Young Oh, Byong Seo Park, Hye Rim Yang, Ho Gyun Lee, Thai Hien Tu, Sunggu Yang, Mi-Ryung Han, Jae Geun Kim
    International Journal of Molecular Sciences.2023; 24(4): 3204.     CrossRef
  • Hormonal Gut–Brain Signaling for the Treatment of Obesity
    Eun Roh, Kyung Mook Choi
    International Journal of Molecular Sciences.2023; 24(4): 3384.     CrossRef
  • Neuronal Blockade of Thyroid Hormone Signaling Increases Sensitivity to Diet-Induced Obesity in Adult Male Mice
    Eva Rial-Pensado, Laurence Canaple, Romain Guyot, Christoffer Clemmensen, Joëlle Wiersema, Shijia Wu, Sabine Richard, Anita Boelen, Timo D Müller, Miguel López, Frédéric Flamant, Karine Gauthier
    Endocrinology.2023;[Epub]     CrossRef
  • Genetic Contributors to Obesity
    Ramya Sivasubramanian, Sonali Malhotra
    Gastroenterology Clinics of North America.2023; 52(2): 323.     CrossRef
  • Neurocomputational mechanisms of food and physical activity decision-making in male adolescents
    Seung-Lark Lim, Amanda S. Bruce, Robin P. Shook
    Scientific Reports.2023;[Epub]     CrossRef
  • Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound
    Yaoheng Yang, Jinyun Yuan, Rachael L. Field, Dezhuang Ye, Zhongtao Hu, Kevin Xu, Lu Xu, Yan Gong, Yimei Yue, Alexxai V. Kravitz, Michael R. Bruchas, Jianmin Cui, Jonathan R. Brestoff, Hong Chen
    Nature Metabolism.2023; 5(5): 789.     CrossRef
  • Changes in hypothalamic mu-opioid receptor expression following acute olanzapine treatment in female rats: Implications for feeding behavior
    Maiken Krogsbaek, Nick Yao Larsen, Anne M. Landau, Connie Sanchez, Jens Randel Nyengaard
    Journal of Chemical Neuroanatomy.2023; 132: 102324.     CrossRef
  • Insulin Resistance and Glucose Metabolism during Infection
    Borros Arneth
    Endocrines.2023; 4(4): 685.     CrossRef
  • The PACAP Paradox: Dynamic and Surprisingly Pleiotropic Actions in the Central Regulation of Energy Homeostasis
    Nikki Le, Sarah Sayers, Veronica Mata-Pacheco, Edward J. Wagner
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • The Link Between Energy-Related Sensations and Metabolism: Implications for Treating Fatigue
    Marco Filippi, Rainer Krähenmann, Patrick Fissler
    Frontiers in Psychology.2022;[Epub]     CrossRef
  • Unaltered Tonic Inhibition in the Arcuate Nucleus of Diet-induced Obese Mice
    Moonsun Sa, Jung Moo Lee, Mingu Gordon Park, Jiwoon Lim, Jong Min Joseph Kim, Wuhyun Koh, Bo-Eun Yoon, C. Justin Lee
    Experimental Neurobiology.2022; 31(3): 147.     CrossRef
  • Hypothalamus–Muscle Parallel Induction of Metabolic Pathways Following Physical Exercise
    Almog Katz, Meital Gonen, Yael Shahar, Asael Roichman, Batia Lerrer, Haim Yosef Cohen
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • Monocarboxylate transporters (MCTs) in skeletal muscle and hypothalamus of less or more physically active mice exposed to aerobic training
    P.P.M. Scariot, F.B. Manchado-Gobatto, W.R. Beck, M. Papoti, P.R. Van Ginkel, C.A. Gobatto
    Life Sciences.2022; 307: 120872.     CrossRef
  • Obesity-Related Genes Expression in Testes and Sperm Parameters Respond to GLP-1 and Caloric Restriction
    Ana S. Correia, Sara C. Pereira, Tiago Morais, Ana D. Martins, Mariana P. Monteiro, Marco G. Alves, Pedro F. Oliveira
    Biomedicines.2022; 10(10): 2609.     CrossRef
  • A pilot study of contrast-enhanced electrical impedance tomography for real-time imaging of cerebral perfusion
    Yuyan Zhang, Jian’an Ye, Yang Jiao, Weirui Zhang, Tao Zhang, Xiang Tian, Xuetao Shi, Feng Fu, Liang Wang, Canhua Xu
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • Repercussions of maternal exposure to high-fat diet on offspring feeding behavior and body composition: a systematic review
    Wenicios Ferreira Chaves, Isabeli Lins Pinheiro, Jacqueline Maria da Silva, Raul Manhães-de-Castro, Raquel da Silva Aragão
    Journal of Developmental Origins of Health and Disease.2021; 12(2): 220.     CrossRef
  • Obesity-associated Pathways of Anthocyanins
    Elif YILDIZ, Metin GULDAS, Pinar ELLERGEZEN, Asli Gul ACAR, Ozan GURBUZ
    Food Science and Technology.2021; 41( suppl 1): 1.     CrossRef
  • Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism
    Ming-Liang Lee, Hirokazu Matsunaga, Yuki Sugiura, Takahiro Hayasaka, Izumi Yamamoto, Taiga Ishimoto, Daigo Imoto, Makoto Suematsu, Norifumi Iijima, Kazuhiro Kimura, Sabrina Diano, Chitoku Toda
    Nature Communications.2021;[Epub]     CrossRef
  • Sleep and Cardiovascular Risk
    Lyudmila Korostovtseva, Mikhail Bochkarev, Yurii Sviryaev
    Sleep Medicine Clinics.2021; 16(3): 485.     CrossRef
  • Evaluation and Management of Early Onset Genetic Obesity in Childhood
    Sonali Malhotra, Ramya Sivasubramanian, Gitanjali Srivastava
    Journal of Pediatric Genetics.2021; 10(03): 194.     CrossRef
  • Gene expression atlas of energy balance brain regions
    Maria Caterina De Rosa, Hannah J. Glover, George Stratigopoulos, Charles A. LeDuc, Qi Su, Yufeng Shen, Mark W. Sleeman, Wendy K. Chung, Rudolph L. Leibel, Judith Y. Altarejos, Claudia A. Doege
    JCI Insight.2021;[Epub]     CrossRef
  • New Peptides as Potential Players in the Crosstalk Between the Brain and Obesity, Metabolic and Cardiovascular Diseases
    Magdalena Czerwińska, Katarzyna Czarzasta, Agnieszka Cudnoch-Jędrzejewska
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • A putative role for lncRNAs in epigenetic regulation of memory
    Ashleigh B. Irwin, Rudhab Bahabry, Farah D. Lubin
    Neurochemistry International.2021; 150: 105184.     CrossRef
  • Alteration of Relative Rates of Biodegradation and Regeneration of Cervical Spine Cartilage through the Restoration of Arterial Blood Flow Access to Rhomboid Fossa: A Hypothesis
    Kirill V. Zhukov, Alexandre A. Vetcher, Bagrat A. Gasparuan, Alexander Y. Shishonin
    Polymers.2021; 13(23): 4248.     CrossRef
  • Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children
    E Breton, V Gagné-Ouellet, K Thibeault, R Guérin, Rj Van Lieshout, P Perron, Mf Hivert, L Bouchard
    Epigenetics.2020; 15(3): 323.     CrossRef
  • The dorsomedial hypothalamus and nucleus of the solitary tract as key regulators in a rat model of chronic obesity
    Chen Zhang, Pernille Barkholt, Jens Christian Nielsen, Ditte Dencker Thorbek, Kristoffer Rigbolt, Niels Vrang, David Paul Drucker Woldbye, Jacob Jelsing
    Brain Research.2020; 1727: 146538.     CrossRef
  • Hypothalamic NAD+-Sirtuin Axis: Function and Regulation
    Eun Roh, Min-Seon Kim
    Biomolecules.2020; 10(3): 396.     CrossRef
  • The Rho/Rac Guanine Nucleotide Exchange Factor Vav1 Regulates Hif-1α and Glut-1 Expression and Glucose Uptake in the Brain
    Jaewoo Hong, Yurim Kim, Sudhirkumar Yanpallewar, P. Charles Lin
    International Journal of Molecular Sciences.2020; 21(4): 1341.     CrossRef
  • Sirtuin (SIRT)-1: At the crossroads of puberty and metabolism
    Carlos F. Aylwin, Alejandro Lomniczi
    Current Opinion in Endocrine and Metabolic Research.2020; 14: 65.     CrossRef
  • Metabolomics Reveals the Alteration of Metabolic Pathway by Alpha-Melanocyte-Stimulating Hormone in B16F10 Melanoma Cells
    Seung-Ho Seo, Jae Kwon Jo, Eun-Ju Kim, Seong-Eun Park, Seo Yeon Shin, Kyung Mok Park, Hong-Seok Son
    Molecules.2020; 25(15): 3384.     CrossRef
  • Noninvasive real-time detection of cerebral blood perfusion in hemorrhagic shock rabbits based on whole-brain magnetic induction phase shift: an experimental study
    Wencai Pan, Wei Zhuang, Yinbao Chong, Mingxin Qin, Yang Li, Jingjing Xiao, Qing Wang, Shihui Zhang, Shuanglin Zhao, Peng Zhao
    Physiological Measurement.2020; 41(9): 095004.     CrossRef
  • Neurochemical regulators of food behavior for pharmacological treatment of obesity: current status and future prospects
    Gayane Sargis Vardanyan, Hasmik Samvel Harutyunyan, Michail Iosif Aghajanov, Ruben Sargis Vardanyan
    Future Medicinal Chemistry.2020; 12(20): 1865.     CrossRef
  • The Co-occurrence of Pediatric Obesity and ADHD: an Understanding of Shared Pathophysiology and Implications for Collaborative Management
    Valerie M. O’Hara, Jennifer L. Curran, Nancy T. Browne
    Current Obesity Reports.2020; 9(4): 451.     CrossRef
  • Constitutive Androstane Receptor: A Peripheral and a Neurovascular Stress or Environmental Sensor
    Fabiana Oliviero, Céline Lukowicz, Badreddine Boussadia, Isabel Forner-Piquer, Jean-Marc Pascussi, Nicola Marchi, Laila Mselli-Lakhal
    Cells.2020; 9(11): 2426.     CrossRef
  • Automated diffusion-based parcellation of the hypothalamus reveals subunit-specific associations with obesity
    Melanie Spindler, Jale Özyurt, Christiane M. Thiel
    Scientific Reports.2020;[Epub]     CrossRef
  • SIRT1 in Astrocytes Regulates Glucose Metabolism and Reproductive Function
    Irene Choi, Emily Rickert, Marina Fernandez, Nicholas J G Webster
    Endocrinology.2019; 160(6): 1547.     CrossRef
  • Hypothalamic mechanisms associated with corticotropin-releasing factor-induced anorexia in chicks
    Jinxin Wang, Justin Matias, Elizabeth R. Gilbert, Tetsuya Tachibana, Mark A. Cline
    Neuropeptides.2019; 74: 95.     CrossRef
  • HMG-CoA synthase 2 drives brain metabolic reprogramming in cocaine exposure
    Xue Shao, Yunxuan Tang, Hailei Long, Hui Gu, Jie Zhang, Pengchi Deng, Yinglan Zhao, Xiaobo Cen
    Neuropharmacology.2019; 148: 377.     CrossRef
  • The Effect of Feeding Behavior on Hypothalamus in Obese Type 2 Diabetic Rats with Glucagon-like Peptide-1 Receptor Agonist Intervention
    Ke Lu, Xiaoyan Chen, Jianhua Yan, Xinchun Li, Chen Huang, Qi Wan, Xuelian Deng, Qiao Zou
    Obesity Facts.2018; 11(3): 181.     CrossRef
  • The Long-Term Impact of High Levels of Alpha-Melanocyte-Stimulating Hormone in Energy Balance Among Obese Adolescents
    Ana Claudia Pelissari Kravchychyn, Raquel Munhoz da Silveira Campos, Flávia Campos Corgosinho, Deborah Cristina Landi Masquio, Sofia Emanuelle de Castro Ferreira Vicente, Yasmin Alaby Martins Ferreira, Patrícia Leão Silva, Aline de Piano Ganen, Lila Missa
    Annals of Nutrition and Metabolism.2018; 72(4): 279.     CrossRef
  • Psychopharmacological advances in eating disorders
    Hubertus Himmerich, Janet Treasure
    Expert Review of Clinical Pharmacology.2018; 11(1): 95.     CrossRef
  • Food engineering into the XXI century
    José Miguel Aguilera
    AIChE Journal.2018; 64(1): 2.     CrossRef
  • The Role of Glucagon-Like Peptide 1 (GLP1) in Type 3 Diabetes: GLP-1 Controls Insulin Resistance, Neuroinflammation and Neurogenesis in the Brain
    Choon Bae, Juhyun Song
    International Journal of Molecular Sciences.2017; 18(11): 2493.     CrossRef
  • “I Am I and My Bacterial Circumstances”: Linking Gut Microbiome, Neurodevelopment, and Depression
    Juan M. Lima-Ojeda, Rainer Rupprecht, Thomas C. Baghai
    Frontiers in Psychiatry.2017;[Epub]     CrossRef
  • Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity
    Katharina Timper, Jens C. Brüning
    Disease Models & Mechanisms.2017; 10(6): 679.     CrossRef
  • Brain glucose metabolism: Role of Wnt signaling in the metabolic impairment in Alzheimer’s disease
    Pedro Cisternas, Nibaldo C. Inestrosa
    Neuroscience & Biobehavioral Reviews.2017; 80: 316.     CrossRef
  • Astrocyte-Specific Deletion of Peroxisome-Proliferator Activated Receptor-γ Impairs Glucose Metabolism and Estrous Cycling in Female Mice
    Marina O Fernandez, Katherine Hsueh, Hyun Tae Park, Consuelo Sauceda, Vicky Hwang, Deepak Kumar, Sun Kim, Emily Rickert, Sumana Mahata, Nicholas J G Webster
    Journal of the Endocrine Society.2017; 1(11): 1332.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
Close layer
Original Article
Endocrine Research
Melanocortin 4 Receptor and Dopamine D2 Receptor Expression in Brain Areas Involved in Food Intake
Ye Ran Yoon, Ja-Hyun Baik
Endocrinol Metab. 2015;30(4):576-583.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.576
  • 4,414 View
  • 55 Download
  • 15 Web of Science
  • 15 Crossref
AbstractAbstract PDFPubReader   
Background

The melanocortin 4 receptor (MC4R) is involved in the regulation of homeostatic energy balance by the hypothalamus. Recent reports showed that MC4R can also control the motivation for food in association with a brain reward system, such as dopamine. We investigated the expression levels of MC4R and the dopamine D2 receptor (D2R), which is known to be related to food rewards, in both the hypothalamus and brain regions involved in food rewards.

Methods

We examined the expression levels of D2R and MC4R by dual immunofluorescence histochemistry in hypothalamic regions and in the bed nucleus of the stria terminalis (BNST), the central amygdala, and the ventral tegmental area of transgenic mice expressing enhanced green fluorescent protein under the control of the D2R gene.

Results

In the hypothalamic area, significant coexpression of MC4R and D2R was observed in the arcuate nucleus. We observed a significant coexpression of D2R and MC4R in the BNST, which has been suggested to be an important site for food reward.

Conclusion

We suggest that MC4R and D2R function in the hypothalamus for control of energy homeostasis and that within the brain regions related with rewards, such as the BNST, the melanocortin system works synergistically with dopamine for the integration of food motivation in the control of feeding behaviors.

Citations

Citations to this article as recorded by  
  • Experimental biology can inform our understanding of food insecurity
    Linda Wilbrecht, Wan Chen Lin, Kathryn Callahan, Melissa Bateson, Kevin Myers, Rachel Ross
    Journal of Experimental Biology.2024;[Epub]     CrossRef
  • Dopamine D2-Subtype Receptors Outside the Blood-Brain Barrier Mediate Enhancement of Mesolimbic Dopamine Release and Conditioned Place Preference by Intravenous Dopamine
    J. Daniel Obray, Christina A. Small, Emily K. Baldwin, Eun Young Jang, Jin Gyeom Lee, Chae Ha Yang, Jordan T. Yorgason, Scott C. Steffensen
    Frontiers in Cellular Neuroscience.2022;[Epub]     CrossRef
  • Reduced MC4R signaling alters nociceptive thresholds associated with red hair
    Kathleen C. Robinson, Lajos V. Kemény, Gillian L. Fell, Andrea L. Hermann, Jennifer Allouche, Weihua Ding, Ajay Yekkirala, Jennifer J. Hsiao, Mack Y. Su, Nicholas Theodosakis, Gabor Kozak, Yuichi Takeuchi, Shiqian Shen, Antal Berenyi, Jianren Mao, Cliffor
    Science Advances.2021;[Epub]     CrossRef
  • Is aripiprazole a key to unlock anorexia nervosa?: A case series
    Akın Tahıllıoğlu, Tuğçe Özcan, Gamze Yüksel, Noorjahan Majroh, Sezen Köse, Burcu Özbaran
    Clinical Case Reports.2020; 8(12): 2826.     CrossRef
  • The Melanocortin System behind the Dysfunctional Eating Behaviors
    Emanuela Micioni Di Bonaventura, Luca Botticelli, Daniele Tomassoni, Seyed Khosrow Tayebati, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani
    Nutrients.2020; 12(11): 3502.     CrossRef
  • Visceral adiposity and insular networks: associations with food craving
    Oren Contreras-Rodríguez, Marta Cano, Raquel Vilar-López, Jacqueline Schmidt Rio-Valle, Juan Verdejo-Román, Juan F. Navas, Cristina Martín-Pérez, Fernando Fernández-Aranda, José Manuel Menchón, Carles Soriano-Mas, Antonio Verdejo-García
    International Journal of Obesity.2019; 43(3): 503.     CrossRef
  • Motivation to eat and not to eat – The psycho-biological conflict in anorexia nervosa
    Guido K.W. Frank, Marisa C. DeGuzman, Megan E. Shott
    Physiology & Behavior.2019; 206: 185.     CrossRef
  • Glucagon-Like Peptide-1 (GLP-1) and 5-Hydroxytryptamine 2c (5-HT2c) Receptor Agonists in the Ventral Tegmental Area (VTA) Inhibit Ghrelin-Stimulated Appetitive Reward
    Erin Howell, Hannah Baumgartner, Lia Zallar, Joaquín Selva, Liv Engel, Paul Currie
    International Journal of Molecular Sciences.2019; 20(4): 889.     CrossRef
  • Oxytocin neurons: integrators of hypothalamic and brainstem circuits in the regulation of macronutrient-specific satiety
    Catherine Hume, Gareth Leng
    Current Opinion in Physiology.2019; 12: 65.     CrossRef
  • Functional Interaction between the Dopamine and Melanocortin Systems of the Brain
    K. V. Derkach, I. V. Romanova, A. O. Shpakov
    Neuroscience and Behavioral Physiology.2018; 48(2): 213.     CrossRef
  • The Leptin, Dopamine and Serotonin Receptors in Hypothalamic POMC-Neurons of Normal and Obese Rodents
    Irina V. Romanova, Kira V. Derkach, Anastasiya L. Mikhrina, Ivan B. Sukhov, Elena V. Mikhailova, Alexander O. Shpakov
    Neurochemical Research.2018; 43(4): 821.     CrossRef
  • The intersection of stress and reward: BNST modulation of aversive and appetitive states
    Sarah Ch'ng, Jingjing Fu, Robyn M. Brown, Stuart J. McDougall, Andrew J. Lawrence
    Progress in Neuro-Psychopharmacology and Biological Psychiatry.2018; 87: 108.     CrossRef
  • Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats
    I. V. Romanova, A. L. Mikhrina, A. O. Shpakov
    Doklady Biological Sciences.2017; 472(1): 11.     CrossRef
  • The partial dopamine D2 receptor agonist aripiprazole is associated with weight gain in adolescent anorexia nervosa
    Guido K. W. Frank, Megan E. Shott, Jennifer O. Hagman, Marissa A. Schiel, Marisa C. DeGuzman, Brogan Rossi
    International Journal of Eating Disorders.2017; 50(4): 447.     CrossRef
  • Rs12970134 near MC4R is associated with appetite and beverage intake in overweight and obese children: A family-based association study in Chinese population
    Shuo Wang, Jieyun Song, Yide Yang, Nitesh V. Chawla, Jun Ma, Haijun Wang, Yiqing Song
    PLOS ONE.2017; 12(5): e0177983.     CrossRef
Close layer
Review Article
Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders
Holly Clarke, Waljit S. Dhillo, Channa N. Jayasena
Endocrinol Metab. 2015;30(2):124-141.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.124
  • 9,356 View
  • 158 Download
  • 108 Web of Science
  • 101 Crossref
AbstractAbstract PDFPubReader   

Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of gonadotrophin releasing hormone (GnRH). Loss of kisspeptin signaling causes hypogonadotrophic hypogonadism in humans and other mammals. Kisspeptin interacts with other neuropeptides such as neurokinin B and dynorphin, to regulate GnRH pulse generation. In addition, a growing body of evidence suggests that kisspeptin signaling be regulated by nutritional status and stress. Kisspeptin may also represent a novel potential therapeutic target in the treatment of fertility disorders. Early human studies suggest that peripheral exogenous kisspeptin administration stimulates gonadotrophin release in healthy adults and in patients with certain forms of infertility. This review aims to concisely summarize what is known about kisspeptin as a regulator of reproductive function, and provide an update on recent advances within this field.

Citations

Citations to this article as recorded by  
  • A prospective study to evaluate whether serum kisspeptin is a marker predictive of the first-trimester miscarriage of women who conceive in IVF
    He Li, Wenbi Zhang, Xiaoxi Sun
    Journal of Assisted Reproduction and Genetics.2024; 41(1): 79.     CrossRef
  • Kisspeptin stimulates sheep ovarian follicular development in vitro through homologous receptors
    B. Divya Sri, S. Harsha Lekha, K. Narendra Gopal Reddy, Deepa Pathipati, B. Rambabu Naik, P. Jagapathy Ramayya, K. Veera Bramhaiah, L.S.S. Varaprasad Reddy, A.V.N. Siva Kumar
    Zygote.2024; 32(1): 49.     CrossRef
  • Maternal Age at Menarche Genes Determines Fetal Growth Restriction Risk
    Evgeny Reshetnikov, Maria Churnosova, Yuliya Reshetnikova, Vadim Stepanov, Anna Bocharova, Victoria Serebrova, Ekaterina Trifonova, Irina Ponomarenko, Inna Sorokina, Olga Efremova, Valentina Orlova, Irina Batlutskaya, Marina Ponomarenko, Vladimir Churnoso
    International Journal of Molecular Sciences.2024; 25(5): 2647.     CrossRef
  • Multiomics Analysis–Based Biomarkers in Diagnosis of Polycystic Ovary Syndrome
    Shikha Rani, Piyush Chandna
    Reproductive Sciences.2023; 30(1): 1.     CrossRef
  • Female Infertility Is Associated with an Altered Expression Profile of Different Members of the Tachykinin Family in Human Granulosa Cells
    Víctor Blasco, Francisco M. Pinto, Ainhoa Fernández-Atucha, Nicolás Prados Dodd, Manuel Fernández-Sánchez, Luz Candenas
    Reproductive Sciences.2023; 30(1): 258.     CrossRef
  • Impact of Ovariectomy on the Anterior Pituitary Gland in Female Rats
    Aki Oride, Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Hiroe Okada, Zhuoma Cairang, Kyo Satoru, Anna Hejmej
    International Journal of Endocrinology.2023; 2023: 1.     CrossRef
  • Male infertility in diabetes mellitus: An insight into the pathophysiology
    AB. M. Kamrul-Hasan, FatemaTuz Zahura Aalpona, Sowrabha Bhat, Sunetra Mondal, Arundhati Dasgupta, Shahjada Selim
    Bangladesh Journal of Endocrinology and Metabolism.2023; 2(2): 65.     CrossRef
  • High Prolactin Concentration Induces Ovarian Granulosa Cell Oxidative Stress, Leading to Apoptosis Mediated by L-PRLR and S-PRLR
    Ruochen Yang, Chunhui Duan, Shuo Zhang, Yunxia Guo, Xinyu Shan, Meijing Chen, Sicong Yue, Yingjie Zhang, Yueqin Liu
    International Journal of Molecular Sciences.2023; 24(19): 14407.     CrossRef
  • Kisspeptin-mediated improvement of sensitivity to BRAF inhibitors in vemurafenib-resistant melanoma cells
    Carlotta Guzzetti, Cristina Corno, Elisabetta Vergani, Luca Mirra, Emilio Ciusani, Monica Rodolfo, Paola Perego, Giovanni L. Beretta
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Impose of KNDy/GnRH neural circuit in PCOS, ageing, cancer and Alzheimer’s disease: StAR actions in prevention of neuroendocrine dysfunction
    Siva Prasad Panda, Adarsh Kesharwani, Gaurav Deep Singh, DSNBK Prasanth, Bhaskara Raju Vatchavai, P.V. Kamala Kumari, Sunil Kumar Panda, Sarada Prasanna Mallick
    Ageing Research Reviews.2023; 92: 102086.     CrossRef
  • Elucidation of the genetic determination of clutch traits in Chinese local chickens of the Laiwu Black breed
    Jie Wang, Zhansheng Liu, Dingguo Cao, Jie Liu, Fuwei Li, Heguo Han, Haixia Han, Qiuxia Lei, Wei Liu, Dapeng Li, Jianxia Wang, Yan Zhou
    BMC Genomics.2023;[Epub]     CrossRef
  • Metabolic actions of kisspeptin signaling: Effects on body weight, energy expenditure, and feeding
    Alexandra D. Hudson, Alexander S. Kauffman
    Pharmacology & Therapeutics.2022; 231: 107974.     CrossRef
  • Intraperitoneal kisspeptin‐10 administration ameliorates sodium arsenite‐induced reproductive toxicity in adult male mice
    Iffat Fatima, Irfan Zia Qureshi
    Andrologia.2022;[Epub]     CrossRef
  • The relation between obesity, kisspeptin, leptin, and male fertility
    Saber Ghaderpour, Rafighe Ghiasi, Hamed Heydari, Rana Keyhanmanesh
    Hormone Molecular Biology and Clinical Investigation.2022; 43(2): 235.     CrossRef
  • Genistein affects gonadotrophin-releasing hormone secretion in GT1-7 cells via modulating kisspeptin receptor and key regulators
    Jingyuan Xiong, Ye Tian, Aru Ling, Zhenmi Liu, Li Zhao, Guo Cheng
    Systems Biology in Reproductive Medicine.2022; 68(2): 138.     CrossRef
  • Ovarian cancer and KiSS-1 gene expression: A consideration of the use of Kisspeptin plus Kisspeptin aptamers in diagnostics and therapy
    Navinder Singh, Richard Hutson, Nathaniel G.N. Milton, Farideh A. Javid
    European Journal of Pharmacology.2022; 917: 174752.     CrossRef
  • In vivo imaging of the GnRH pulse generator reveals a temporal order of neuronal activation and synchronization during each pulse
    Aleisha M. Moore, Lique M. Coolen, Michael N. Lehman
    Proceedings of the National Academy of Sciences.2022;[Epub]     CrossRef
  • The role of leptin and low testosterone in obesity
    Kajal Khodamoradi, Zahra Khosravizadeh, Deepa Seetharam, Suresh Mallepalli, Natoli Farber, Himanshu Arora
    International Journal of Impotence Research.2022; 34(7): 704.     CrossRef
  • Chlorobisphenol A activated kisspeptin/GPR54-GnRH neuroendocrine signals through ERα and GPER pathway in neuronal GT1-7 cells
    Bingli Lei, Lanbing Xu, Yaoyao Huang, Yun Liu, Mengjie Yu, Qianqian Tang
    Ecotoxicology and Environmental Safety.2022; 233: 113290.     CrossRef
  • Genetic factors in precocious puberty
    Young Suk Shim, Hae Sang Lee, Jin Soon Hwang
    Clinical and Experimental Pediatrics.2022; 65(4): 172.     CrossRef
  • Hyperandrogenism induces proportional changes in the expression of Kiss-1, Tac2, and DynA in hypothalamic KNDy neurons
    Hiroe Okada, Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Aki Oride, Satoru Kyo
    Reproductive Biology and Endocrinology.2022;[Epub]     CrossRef
  • Kisspeptin‐10 in cryodiluent improves the post‐thaw quality of Nili‐Ravi buffalo ( Bubalus bubalis ) bull spermatozoa
    Muhammad Hammad Fayyaz, Syed Murtaza Hassan Andrabi, Muhammad Shafiq Haider, Mubashir Ali Khalique, Syed Aftab Hussain Shah
    Andrologia.2022;[Epub]     CrossRef
  • The role of Kisspeptin signaling in Oocyte maturation
    Saeed Masumi, Eun Bee Lee, Iman Dilower, Sameer Upadhyaya, V. Praveen Chakravarthi, Patrick E. Fields, M. A. Karim Rumi
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Use of kisspeptin to trigger oocyte maturation during in vitro fertilisation (IVF) treatment
    Bhavna Sharma, Kanyada Koysombat, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Neurotransmitters, neuropeptides and calcium in oocyte maturation and early development
    Maitha M. Alhajeri, Rayyah R. Alkhanjari, Rawad Hodeify, Ali Khraibi, Hamdan Hamdan
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Sex-specific association between urinary kisspeptin and pubertal development
    Rafaella Sales de Freitas, Thiago F A França, Sabine Pompeia
    Endocrine Connections.2022;[Epub]     CrossRef
  • Overexpression of KiSS1 Induces the Proliferation of Hepatocarcinoma and Increases Metastatic Potential by Increasing Migratory Ability and Angiogenic Capacity
    Cho-Won Kim, Hong Kyu Lee, Min-Woo Nam, Youngdong Choi, Kyung-Chul Choi
    Molecules and Cells.2022; 45(12): 935.     CrossRef
  • Obesity and male infertility: Mechanisms and management
    Kristian Leisegang, Pallav Sengupta, Ashok Agarwal, Ralf Henkel
    Andrologia.2021;[Epub]     CrossRef
  • Interrelationships between kisspeptin and FSH in control of porcine ovarian cell functions
    Z. Fabová, A.V. Sirotkin
    Domestic Animal Endocrinology.2021; 74: 106520.     CrossRef
  • Effects of Recombinant Human Growth Hormone on the Onset of Puberty, Leydig Cell Differentiation, Spermatogenesis and Hypothalamic KISS1 Expression in Immature Male Rats
    Kyoung Huh, Won Heun Nah, Yang Xu, Mi Jung Park, Myung Chan Gye
    The World Journal of Men's Health.2021; 39(2): 381.     CrossRef
  • The effect of different exogenous kisspeptins on sex hormones and reproductive indices of the goldfish (Carassius auratus) broodstock
    AbdolMajid Valipour, Behrooz Heidari, S. Mohsen Asghari, Saeed Balalaie, Hanieh Rabouti, Navid Omidian
    Journal of Fish Biology.2021; 98(4): 1137.     CrossRef
  • Roles of kisspeptin in IVF/ICSI-treated infertile women and in human granulosa cells
    Lixian Qin, Chantacha Sitticharoon, Somsin Petyim, Issarawan Keadkraichaiwat, Rungnapa Sririwichitchai, Pailin Maikeaw, Malika Churintaraphan, Chanakarn Sripong
    Experimental Biology and Medicine.2021; 246(8): 996.     CrossRef
  • Expression analysis of neuropeptide FF receptors on neuroendocrine-related neurons in the rat brain using highly sensitive in situ hybridization
    Shimpei Higo, Moeko Kanaya, Hitoshi Ozawa
    Histochemistry and Cell Biology.2021; 155(4): 465.     CrossRef
  • Pyometra and estrous cycle modulate the uterine expression of the kisspeptin system and angiogenic and immune factors in cats
    Luciano Cardoso Santos, Jeane Martinha dos Anjos Cordeiro, Larissa da Silva Santana, Larissa Rodrigues Santana, Bianca Reis Santos, Erikles Macêdo Barbosa, Thayná Queiroz Menezes da Silva, Janaina Maria Xavier Corrêa, Mário Sergio Lima Lavor, Elisângela B
    Biology of Reproduction.2021; 104(3): 548.     CrossRef
  • Kisspeptin regulates the development of caprine primordial follicles in vitro
    Manjula Priyantha Sumith Magamage, Sriravali Sathagopam, Kiran Avula, Di Neththi Nimesh Madushanka, Sathya Velmurugan
    Journal of Animal Reproduction and Biotechnology.2021; 36(1): 51.     CrossRef
  • Kisspeptin-10 Administration Regulates mTOR and AKT Activities and Oxidative Stress in Mouse Cardiac Tissue
    H. Akkaya
    Journal of Evolutionary Biochemistry and Physiology.2021; 57(2): 270.     CrossRef
  • Gametogenic and steroidogenic action of kisspeptin-10 in the Asian catfish, Clarias batrachus: Putative underlying mechanistic cascade
    Ankur Singh, Bechan Lal, Jyoti Parkash, Robert P. Millar
    Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology.2021; 256: 110642.     CrossRef
  • Dopamine D2 Receptor Antagonist Alters the Testosterone Release and Kisspeptin/GPR54 Signaling in Food-Restricted Rats
    Khatereh Nourmohammadi, Farrin Babaei-Balderlou, Seyyed Meysam Abtahi-Foroushani
    Iranian Journal of Science and Technology, Transactions A: Science.2021; 45(6): 1879.     CrossRef
  • Expression of reproductive‐related genes and changes in oocyte maturation of goldfish broodstock (Carassius auratus) following injection of different exogenous kisspeptins
    AbdolMajid Valipour, Behrooz Heidari, Hamidreza Vaziri, S. Mohsen Asghari
    Reproduction in Domestic Animals.2021; 56(10): 1349.     CrossRef
  • Seasonal expression and distribution of kisspeptin1 (kiss1) in the ovary and testis of freshwater catfish, Clarias batrachus: A putative role in steroidogenesis
    Ankur Singh, Bechan Lal, Ishwar S. Parhar, Robert P. Millar
    Acta Histochemica.2021; 123(6): 151766.     CrossRef
  • Benzo[a]pyrene impairs the migratory pattern of human gonadotropin-releasing-hormone-secreting neuroblasts
    Giulia Guarnieri, Matteo Becatti, Paolo Comeglio, Linda Vignozzi, Mario Maggi, Gabriella Barbara Vannelli, Annamaria Morelli
    European Journal of Histochemistry.2021;[Epub]     CrossRef
  • Bu-Shen-Zhu-Yun decoction induces PRLR deubiquitination and JAK2/STAT5 activation via CSN5 in vitro
    Hua Feng, Huifang Zhou, Jianxia Lu, Qing Zhang, Xingran Tang, Yujie Shang
    Aging.2021; 13(16): 20418.     CrossRef
  • Endocrinopathies and Male Infertility
    Pallav Sengupta, Sulagna Dutta, Ivan Rolland Karkada, Suresh V. Chinni
    Life.2021; 12(1): 10.     CrossRef
  • The Correlation between Hormonal Disturbance in PCOS Women and Serum Level of Kisspeptin
    Razaw O. Ibrahim, Shirwan H. Omer, Chro N. Fattah
    International Journal of Endocrinology.2020; 2020: 1.     CrossRef
  • Investigating the kisspeptin system in the hermaphrodite teleost gilthead seabream (Sparus aurata)
    Catarina C.V. Oliveira, Elsbeth McStay, Elsa Cabrita, Maria Filipa Castanheira, Hervé Migaud, Maria Teresa Dinis, Andrew Davie
    Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology.2020; 241: 110624.     CrossRef
  • Maternal plasma kisspeptin‐10 level in preeclamptic pregnant women and its relation in changing their reproductive hormones
    Maysoun A. Al‐Kaabi, Farqad B. Hamdan, Hisham Al‐Matubsi
    Journal of Obstetrics and Gynaecology Research.2020; 46(4): 575.     CrossRef
  • The potential therapeutic effects of Lactobacillus plantarum and inulin on serum and testicular reproductive markers in diabetic male rats
    Marziyeh Rahimiyan-Heravan, Leila Roshangar, Pouran Karimi, Safa Sefidgari-Abrasi, Mohammad Morshedi, Maryam Saghafi-Asl, Khadijeh Bavafa-Valenlia
    Diabetology & Metabolic Syndrome.2020;[Epub]     CrossRef
  • Lifestyle, metabolic disorders and male hypogonadism – A one-way ticket?
    Luís Crisóstomo, Sara C. Pereira, Mariana P. Monteiro, João F. Raposo, Pedro F. Oliveira, Marco G. Alves
    Molecular and Cellular Endocrinology.2020; 516: 110945.     CrossRef
  • Female infertility is associated with an altered expression of the neurokinin B/neurokinin B receptor and kisspeptin/kisspeptin receptor systems in ovarian granulosa and cumulus cells
    Victor Blasco, Francisco M. Pinto, Ainhoa Fernández-Atucha, Cristina González-Ravina, Manuel Fernández-Sánchez, Luz Candenas
    Fertility and Sterility.2020; 114(4): 869.     CrossRef
  • Cafeteria diet-induced obesity reduces leptin-stimulated NADPH-diaphorase reactivity in the hypothalamic arcuate nucleus of rats
    Milen Hristov, Boycho Landzhov, Krassimira Yakimova
    Acta Histochemica.2020; 122(7): 151616.     CrossRef
  • Potential Cardiovascular and Metabolic Beneficial Effects of ω-3 PUFA in Male Obesity Secondary Hypogonadism Syndrome
    Annalisa Noce, Giulia Marrone, Francesca Di Daniele, Manuela Di Lauro, Anna Pietroboni Zaitseva, Georgia Wilson Jones, Antonino De Lorenzo, Nicola Di Daniele
    Nutrients.2020; 12(9): 2519.     CrossRef
  • Peripheral action of kisspeptin at reproductive tissues—role in ovarian function and embryo implantation and relevance to assisted reproductive technology in livestock: a review
    Michael J D’Occhio, Giuseppe Campanile, Pietro S Baruselli
    Biology of Reproduction.2020; 103(6): 1157.     CrossRef
  • Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring
    Vicente Mustieles, Shereen Cynthia D'Cruz, Stephan Couderq, Andrea Rodríguez-Carrillo, Jean-Baptiste Fini, Tim Hofer, Inger-Lise Steffensen, Hubert Dirven, Robert Barouki, Nicolás Olea, Mariana F. Fernández, Arthur David
    Environment International.2020; 144: 105811.     CrossRef
  • Neonatal exposure to genistein affects reproductive physiology and behavior in female and male Long-Evans rats
    Maryam Ali, Timothy Michael Broyles, Lourdes K. Davis, Chantal M.F. Gonzalez, Devon Lucero, Lainey Stary, Fay A. Guarraci
    Behavioural Pharmacology.2020; 31(7): 610.     CrossRef
  • The LH/FSH ratio is not a sex-dimorphic marker after infancy: data from 6417 healthy individuals and 125 patients with Differences of Sex Development
    Marie L Ljubicic, Kirstine Jespersen, Lise Aksglaede, Casper P Hagen, Jørgen H Petersen, Helle R Andersen, Allan Linneberg, Katharina M Main, Anna-Maria Andersson, Trine H Johannsen, Anders Juul
    Human Reproduction.2020; 35(10): 2323.     CrossRef
  • Kisspeptin Influences the Reproductive Axis and Circulating Levels of microRNAs in Senegalese Sole
    Catarina C. V. Oliveira, Elvira Fatsini, Ignacio Fernández, Catarina Anjos, François Chauvigné, Joan Cerdà, Robin Mjelle, Jorge M. O. Fernandes, Elsa Cabrita
    International Journal of Molecular Sciences.2020; 21(23): 9051.     CrossRef
  • Effects of sevoflurane on reproductive function of male rats and its main mechanism of action
    Yanhong Cui, Jingying Liu, Yulin Zhu, Kun Xie, Jingui Yu, Lingzhi Yu, Yanhao Wang
    Inhalation Toxicology.2019; 31(11-12): 392.     CrossRef
  • Male Obesity-related Secondary Hypogonadism – Pathophysiology, Clinical Implications and Management
    Cornelius J Fernandez, Elias C Chacko, Joseph M Pappachan
    European Endocrinology.2019; 15(2): 83.     CrossRef
  • Perturbation of Nuclear Hormone Receptors by Endocrine Disrupting Chemicals: Mechanisms and Pathological Consequences of Exposure
    Julie M. Hall, Callie W. Greco
    Cells.2019; 9(1): 13.     CrossRef
  • Duplications in 19p13.3 are associated with male infertility
    Vertika Singh, Renu Bala, Arijit Chakraborty, Singh Rajender, Sameer Trivedi, Kiran Singh
    Journal of Assisted Reproduction and Genetics.2019; 36(10): 2171.     CrossRef
  • The Chronic and Unpredictable Stress Suppressed Kisspeptin Expression during Ovarian Cycle in Mice
    Seung-Joon Kim
    Journal of Animal Reproduciton and Biotechnology.2019; 34(1): 40.     CrossRef
  • KiSS1 in regulation of metastasis and response to antitumor drugs
    Cristina Corno, Paola Perego
    Drug Resistance Updates.2019; 42: 12.     CrossRef
  • Kisspeptin and attributes of infertile males and females: A cross‐sectional study in a subset of Pakistani population
    Rehana Rehman, Syeda S. Fatima, Faiza Alam, Mussarat Ashraf, Shaheen Zafar
    Andrologia.2019;[Epub]     CrossRef
  • Puberty and the Evolution of Developmental Science
    Carol M. Worthman, Samantha Dockray, Kristine Marceau
    Journal of Research on Adolescence.2019; 29(1): 9.     CrossRef
  • Kisspeptin/Neurokinin B/Dynorphin (KNDy) cells as integrators of diverse internal and external cues: evidence from viral-based monosynaptic tract-tracing in mice
    Aleisha M. Moore, Lique M. Coolen, Michael N. Lehman
    Scientific Reports.2019;[Epub]     CrossRef
  • Region-specific changes in brain kisspeptin receptor expression during estrogen depletion and the estrous cycle
    Saeko Ozaki, Shimpei Higo, Kinuyo Iwata, Hidehisa Saeki, Hitoshi Ozawa
    Histochemistry and Cell Biology.2019; 152(1): 25.     CrossRef
  • Minireview: The Epigenetic Modulation of KISS1 in Reproduction and Cancer
    Maria Letizia Motti, Rosaria Meccariello
    International Journal of Environmental Research and Public Health.2019; 16(14): 2607.     CrossRef
  • Altered expression of the kisspeptin/KISS1R and neurokinin B/NK3R systems in mural granulosa and cumulus cells of patients with polycystic ovarian syndrome
    Victor Blasco, Francisco M. Pinto, Ainhoa Fernández-Atucha, Nicolás Prados, Manuel Tena-Sempere, Manuel Fernández-Sánchez, Luz Candenas
    Journal of Assisted Reproduction and Genetics.2019; 36(1): 113.     CrossRef
  • Non hormonal management options for menstrual cycle irregularities
    I. V. Kuznetsova
    Medical Council.2019; (13): 16.     CrossRef
  • New markers for the detection of polycystic ovary syndrome
    Elham Sharif
    Obstetrics & Gynecology International Journal.2019;[Epub]     CrossRef
  • Antisense techniques provide robust decrease in GnRH receptor expression with minimal cytotoxicity in GT1-7 cells
    Maurice Andre Recanati, Hongling Du, Katherine J. Kramer, Maik Hüttemann, Robert A. Welch
    Systems Biology in Reproductive Medicine.2018; 64(5): 389.     CrossRef
  • Additive effect of simultaneous continuous administration of degarelix and TAK-448 on LH suppression in a castrated rat model
    Jacek Stalewski, Diane M. Hargrove, Monica Wolfe, Trudy A. Kohout, Adeela Kamal
    European Journal of Pharmacology.2018; 824: 24.     CrossRef
  • Various responses of male pituitary–gonadal axis to different intensities of long-term exercise: Role of expression of KNDY-related genes
    Nazli Khajehnasiri, Homayoun Khazali, Farzam Sheikhzadeh
    Journal of Biosciences.2018; 43(4): 569.     CrossRef
  • The role of neuropeptides and neurotransmitters on kisspeptin/kiss1r-signaling in female reproduction
    Saman Saedi, Arezoo Khoradmehr, Jafarzadeh Shirazi Mohammad Reza, Amin Tamadon
    Journal of Chemical Neuroanatomy.2018; 92: 71.     CrossRef
  • Neuropeptidome of the Hypothalamus and Pituitary Gland of Indicine × Taurine Heifers: Evidence of Differential Neuropeptide Processing in the Pituitary Gland before and after Puberty
    Kasey L. DeAtley, Michelle L. Colgrave, Angela Cánovas, Gene Wijffels, Ryan L. Ashley, Gail A. Silver, Gonzalo Rincon, Juan F. Medrano, Alma Islas-Trejo, Marina R. S. Fortes, Antonio Reverter, Laercio Porto-Neto, Sigrid A. Lehnert, Milton G. Thomas
    Journal of Proteome Research.2018; 17(5): 1852.     CrossRef
  • Kisspeptin as a new serum biomarker to discriminate miscarriage from viable intrauterine pregnancy
    Chantae Sullivan-Pyke, Daniel J. Haisenleder, Suneeta Senapati, Olivia Nicolais, Esther Eisenberg, Mary D. Sammel, Kurt T. Barnhart
    Fertility and Sterility.2018; 109(1): 137.     CrossRef
  • Thalamic integration of social stimuli regulating parental behavior and the oxytocin system
    Arpad Dobolyi, Melinda Cservenák, Larry J. Young
    Frontiers in Neuroendocrinology.2018; 51: 102.     CrossRef
  • Aging and estradiol effects on gene expression in the medial preoptic area, bed nucleus of the stria terminalis, and posterodorsal medial amygdala of male rats
    Victoria L. Nutsch, Margaret R. Bell, Ryan G. Will, Weiling Yin, Andrew Wolfe, Ross Gillette, Juan M. Dominguez, Andrea C. Gore
    Molecular and Cellular Endocrinology.2017; 442: 153.     CrossRef
  • Naloxegol, an opioid antagonist with reduced CNS penetration: Mode-of-action and human relevance for rat testicular tumours
    Håkan Andersson, Terri Mitchard, Nakpangi Johnson, Eike Floettmann
    Toxicology and Applied Pharmacology.2017; 329: 85.     CrossRef
  • The Role of Kisspeptin in Female Reproduction
    Sareh Zeydabadi Nejad, Fahimeh Ramezani Tehrani, Azita Zadeh-Vakili
    International Journal of Endocrinology and Metabolism.2017;[Epub]     CrossRef
  • The impact of postnatal leuprolide acetate treatment on reproductive characteristics in a rodent model of polycystic ovary syndrome
    Lady Katerine Serrano Mujica, Kalyne Bertolin, Alessandra Bridi, Werner Giehl Glanzner, Vitor Braga Rissi, Flávia de los Santos de Camargo, Renato Zanella, Osmar Damian Prestes, Rafael Noal Moresco, Alfredo Quites Antoniazzi, Paulo Bayard Dias Gonçalves,
    Molecular and Cellular Endocrinology.2017; 442: 125.     CrossRef
  • GLP-1 increases Kiss-1 mRNA expression in kisspeptin-expressing neuronal cells†
    Aki Oride, Haruhiko Kanasaki, Tselmeg Mijiddorj, Unurjargal Sukhbaatar, Tomomi Hara, Tuvshintugs Tumurbaatar, Satoru Kyo
    Biology of Reproduction.2017; 97(2): 240.     CrossRef
  • Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells
    Ariel Poliandri, Duncan Miller, Sasha Howard, Muriel Nobles, Gerard Ruiz-Babot, Stephen Harmer, Andrew Tinker, Tristan McKay, Leonardo Guasti, Leo Dunkel
    Molecular and Cellular Endocrinology.2017; 447: 12.     CrossRef
  • How is GnRH regulated in GnRH-producing neurons? Studies using GT1-7 cells as a GnRH-producing cell model
    Haruhiko Kanasaki, Aki Oride, Tselmeg Mijiddorj, Unurjargal Sukhbaatar, Satoru Kyo
    General and Comparative Endocrinology.2017; 247: 138.     CrossRef
  • Obesity, male infertility, and the sperm epigenome
    James R. Craig, Timothy G. Jenkins, Douglas T. Carrell, James M. Hotaling
    Fertility and Sterility.2017; 107(4): 848.     CrossRef
  • Seasonal infertility in gilts and sows: Aetiology, clinical implications and treatments
    Fabio De Rensis, Adam J. Ziecik, Roy N. Kirkwood
    Theriogenology.2017; 96: 111.     CrossRef
  • Ovulation, A Sign of Health
    Pilar Vigil, Carolina Lyon, Betsi Flores, Hernán Rioseco, Felipe Serrano
    The Linacre Quarterly.2017; 84(4): 343.     CrossRef
  • Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock response
    Antônio Azambuja Miragem, Paulo Ivo Homem de Bittencourt
    Human Reproduction Update.2017; 23(5): 600.     CrossRef
  • Kisspeptin as a promising oocyte maturation trigger for in vitro fertilisation in humans
    Miro Kasum, Daniela Franulić, Ermin Čehić, Slavko Orešković, Albert Lila, Emina Ejubović
    Gynecological Endocrinology.2017; 33(8): 583.     CrossRef
  • Molecular cloning and characterization of kiss1 in Brandt's voles ( Lasiopodomys brandtii )
    Yan Chen, Lan Liu, Zhengguang Li, Dawei Wang, Ning Li, Ying Song, Cong Guo, Xiaohui Liu
    Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology.2017; 208-209: 68.     CrossRef
  • Loss of the Habenula Intrinsic Neuromodulator Kisspeptin1 Affects Learning in Larval Zebrafish
    Charlotte Lupton, Mohini Sengupta, Ruey-Kuang Cheng, Joanne Chia, Vatsala Thirumalai, Suresh Jesuthasan
    eneuro.2017; 4(3): ENEURO.0326-16.2017.     CrossRef
  • Correlation of Kisspeptin-10 level and fetal well-being in preeclamptic patients
    Maysoun A. Ziyaraa, Farqad B. Hamdan, Liqaa R. Mousa
    Taiwanese Journal of Obstetrics and Gynecology.2016; 55(6): 840.     CrossRef
  • Neuropeptide derivatives to regulate the reproductive axis: Kisspeptin receptor (KISS1R) ligands and neurokinin‐3 receptor (NK3R) ligands
    Shinya Oishi, Nobutaka Fujii
    Peptide Science.2016; 106(4): 588.     CrossRef
  • An update on the prevention of ovarian hyperstimulation syndrome
    Omar El Tokhy, Julia Kopeika, Tarek El-Toukhy
    Women's Health.2016; 12(5): 496.     CrossRef
  • Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells1
    Jordán García-Ortega, Francisco M. Pinto, Nicolás Prados, Aixa R. Bello, Teresa A. Almeida, Manuel Fernández-Sánchez, Luz Candenas
    Biology of Reproduction.2016;[Epub]     CrossRef
  • Kisspeptin Regulation of Neuronal Activity throughout the Central Nervous System
    Xinhuai Liu, Allan E. Herbison
    Endocrinology and Metabolism.2016; 31(2): 193.     CrossRef
  • RF-amide neuropeptides and their receptors in Mammals: Pharmacological properties, drug development and main physiological functions
    Raphaëlle Quillet, Safia Ayachi, Frédéric Bihel, Khadija Elhabazi, Brigitte Ilien, Frédéric Simonin
    Pharmacology & Therapeutics.2016; 160: 84.     CrossRef
  • Kisspeptin-mediated regulation of the morpho-functional state of the rat testicles under the effect of silver nanoparticles
    V. Kalinovskyi, A. Pustovalov, M. Dzerzhynskyi, G. Grodzyuk, N. Andriushina
    Bulletin of Taras Shevchenko National University of Kyiv. Series: Problems of Physiological Functions Regulation.2016; 20(1): 8.     CrossRef
  • Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin may alter LH release patterns by abolishing sex differences in GABA/glutamate cell number and modifying the transcriptome of the male anteroventral periventricular nucleus
    Javier Del Pino Sans, Kelsey J. Clements, Alexander Suvorov, Sudha Krishnan, Hillary L. Adams, Sandra L. Petersen
    Neuroscience.2016; 329: 239.     CrossRef
  • Control of puberty onset and fertility by gonadotropin-releasing hormone neurons
    Allan E. Herbison
    Nature Reviews Endocrinology.2016; 12(8): 452.     CrossRef
  • Patent Highlights June–July 2015
    Hermann AM Mucke
    Pharmaceutical Patent Analyst.2015; 4(6): 423.     CrossRef
Close layer
Original Article
Adrenal gland
Effects of Chronic Restraint Stress on Body Weight, Food Intake, and Hypothalamic Gene Expressions in Mice
Joo Yeon Jeong, Dong Hoon Lee, Sang Soo Kang
Endocrinol Metab. 2013;28(4):288-296.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.288
  • 6,556 View
  • 140 Download
  • 128 Crossref
AbstractAbstract PDFPubReader   
Background

Stress affects body weight and food intake, but the underlying mechanisms are not well understood.

Methods

We evaluated the changes in body weight and food intake of ICR male mice subjected to daily 2 hours restraint stress for 15 days. Hypothalamic gene expression profiling was analyzed by cDNA microarray.

Results

Daily body weight and food intake measurements revealed that both parameters decreased rapidly after initiating daily restraint stress. Body weights of stressed mice then remained significantly lower than the control body weights, even though food intake slowly recovered to 90% of the control intake at the end of the experiment. cDNA microarray analysis revealed that chronic restraint stress affects the expression of hypothalamic genes possibly related to body weight control. Since decreases of daily food intake and body weight were remarkable in days 1 to 4 of restraint, we examined the expression of food intake-related genes in the hypothalamus. During these periods, the expressions of ghrelin and pro-opiomelanocortin mRNA were significantly changed in mice undergoing restraint stress. Moreover, daily serum corticosterone levels gradually increased, while leptin levels significantly decreased.

Conclusion

The present study demonstrates that restraint stress affects body weight and food intake by initially modifying canonical food intake-related genes and then later modifying other genes involved in energy metabolism. These genetic changes appear to be mediated, at least in part, by corticosterone.

Citations

Citations to this article as recorded by  
  • Potential antimicrobial activity of camel milk as a traditional functional food against foodborne pathogens in vivo and in vitro
    Amro Abdelazez, Sherif Melak, Heba Abdelmotaal, Garsa Alshehry, Huda Al-jumayi, Eman Algarni, Xiang-Chen Meng
    Food Science and Technology International.2024; 30(3): 239.     CrossRef
  • Effects of home‐cage elevation on behavioral tests in mice
    Hiroshi Ueno, Yu Takahashi, Shinji Murakami, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara
    Brain and Behavior.2024;[Epub]     CrossRef
  • Anaesthesia-induced Changes in Genomic Expression Leading to Neurodegeneration
    Khalid Saad Alharbi, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Fahad A. Al-Abbasi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Mohammed Albratty, Asim Najmi, Gaurav Gupta
    CNS & Neurological Disorders - Drug Targets.2024; 23(4): 411.     CrossRef
  • Stress integration by an ascending adrenergic-melanocortin circuit
    Connor Laule, Nilufer Sayar-Atasoy, Iltan Aklan, Hyojin Kim, Tayfun Ates, Debbie Davis, Deniz Atasoy
    Neuropsychopharmacology.2024;[Epub]     CrossRef
  • Stress-induced changes in cognitive function and intestinal barrier integrity can be ameliorated by venlafaxine and synbiotic supplementations
    Sarawut Lapmanee, Nattapon Supkamonseni, Sakkarin Bhubhanil, Nattakan Treesaksrisakul, Chaiyos Sirithanakorn, Mattaka Khongkow, Katawut Namdee, Piyaporn Surinlert, Chittipong Tipbunjong, Prapimpun Wongchitrat
    PeerJ.2024; 12: e17033.     CrossRef
  • Effects of prenatal THC vapor exposure on body weight, glucose metabolism, and feeding behaviors in chow and high-fat diet fed rats
    Catherine Hume, Samantha L. Baglot, Lucia Javorcikova, Savannah H. M. Lightfoot, Jessica Scheufen, Matthew N. Hill
    International Journal of Obesity.2024;[Epub]     CrossRef
  • The inhalation effect of Osmanthus fragrans var. Aurantiacus on physiological parameters in chronically stressed rats
    Moon Yeon Youn, Jin-Ju Cho, Seong Jun Hong, Seong Min Jo, Hyangyeon Jeong, Sojeong Yoon, Younglan Ban, Hyeonjin Park, Jae Kyeom Kim, Young Jun Kim, Eui-Cheol Shin
    Food Chemistry: X.2024; 22: 101304.     CrossRef
  • Stress exacerbates pancreatic cancer both directly and indirectly by creating an immunosuppressive environment
    Takahiro Ikeda, Tomohiko Adachi, Takayuki Tanaka, Daisuke Miyamoto, Hajime Imamura, Hajime Matsushima, Kazuo Yamamoto, Masaaki Hidaka, Kengo Kanetaka, Susumu Eguchi
    Journal of Hepato-Biliary-Pancreatic Sciences.2023; 30(7): 935.     CrossRef
  • Up-regulation of BDNF/TrkB signaling by δ opioid receptor agonist SNC80 modulates depressive-like behaviors in chronic restraint-stressed mice
    Shuo Wu, Kuan Ning, Yujun Wang, Lesha Zhang, Jinggen Liu
    European Journal of Pharmacology.2023; 942: 175532.     CrossRef
  • Assessment of Stress Caused by Environmental Changes for Improving the Welfare of Laboratory Beagle Dogs
    Gwang-Hoon Lee, Woori Jo, Tae-Ku Kang, Taeho Oh, KilSoo Kim
    Animals.2023; 13(6): 1095.     CrossRef
  • Butein ameliorates chronic stress induced atherosclerosis via targeting anti-inflammatory, anti-fibrotic and BDNF pathways
    Mujeeba Rehman, Rishabh Chaudhary, Sonu Rajput, Vipul Agarwal, Arjun Singh Kaushik, Siddhi Srivastava, Sukriti Srivastava, Rohit Singh, Irfan Aziz, Sanjay Singh, Vikas Mishra
    Physiology & Behavior.2023; 267: 114207.     CrossRef
  • Impact of exercise on brain-bone marrow interactions in chronic stress: potential mechanisms preventing stress-induced hypertension
    Thu Van Nguyen, Ko Yamanaka, Keisuke Tomita, Jasenka Zubcevic, Sabine S. S. Gouraud, Hidefumi Waki
    Physiological Genomics.2023; 55(5): 222.     CrossRef
  • Effect of mobile phone radiofrequency electromagnetic radiations on oxidative stress and feeding behaviour in Sprague Dawley (SD) rats
    Pravallika Pagadala, Vinutha Shankar M S, Sumathi M E
    Indian Journal of Physiology and Pharmacology.2023; 67: 131.     CrossRef
  • Mechanical loading and autophagy: A study on the BoNT-A injection-induced condylar cartilage degeneration
    Siyu Hou, Sisi Peng, Hongwei Dai, Jinlin Song, Ling Xu, Jianping Zhou, Lingjie Li
    Archives of Biochemistry and Biophysics.2023; 749: 109788.     CrossRef
  • Continuous deep brain stimulation of the nucleus accumbens reduces food intake but does not affect body weight in mice fed a high-fat diet
    Harold F. Hounchonou, Hui Tang, Raik Paulat, Andrea Kühn, Joachim Spranger, Christoph van Riesen, Lukas Maurer
    Scientific Reports.2023;[Epub]     CrossRef
  • Chronic stress predisposes to the aggravation of inflammation in autoimmune diseases with focus on rheumatoid arthritis and psoriasis
    Rishabh Chaudhary, Ajay Prasad, Vipul Agarwal, Mujeeba Rehman, Anand Kumar, Arjun Singh Kaushik, Siddhi Srivastava, Sukriti Srivastava, Vikas Mishra
    International Immunopharmacology.2023; 125: 111046.     CrossRef
  • Venlafaxine and synbiotic attenuated learned fear-like behavior and recognition memory impairment in immobilized-stressed rats
    Sarawut Lapmanee, Sakkarin Bhubhanil, Siriwan Sriwong, Mattaka Khongkow, Katawut Namdee, Prapimpun Wongchitrat, Pawin Pongkorpsakol
    Physiology and Pharmacology.2023; 27(2): 171.     CrossRef
  • Gonadotropin levels reduced in seven days immobilization stress-induced depressive-like behavior in female rats
    Zafer Sahin, Alpaslan Ozkurkculer, Omer Faruk Kalkan, Funda Gulcu Bulmus, Ozgur Bulmus, Selim Kutlu
    Journal of Basic and Clinical Physiology and Pharmacology.2022; 33(2): 199.     CrossRef
  • Impact of the Sound of Magnetic Resonance Imaging Pulse Sequences in Awake Mice
    Joana Almeida, Frederico Severo, Daniel Nunes
    Journal of Applied Animal Welfare Science.2022; 25(1): 75.     CrossRef
  • Virgin coconut oil abrogates depression-associated cognitive deficits by modulating hippocampal antioxidant balance, GABAergic and glutamatergic receptors in mice
    Edem Ekpenyong Edem, Blessing Eghosa Ihaza, Adedamola Adediran Fafure, Azeez Olakunle Ishola, Kate Eberechukwu Nebo, Linus Anderson Enye, Elizabeth Toyin Akinluyi
    Drug Metabolism and Personalized Therapy.2022; 37(2): 177.     CrossRef
  • Characterizing the behavioral and neuroendocrine features of susceptibility and resilience to social stress
    Dalia Murra, Kathryn L. Hilde, Anne Fitzpatrick, Pamela M. Maras, Stanley J. Watson, Huda Akil
    Neurobiology of Stress.2022; 17: 100437.     CrossRef
  • VTA-projecting cerebellar neurons mediate stress-dependent depression-like behaviors
    Soo Ji Baek, Jin Sung Park, Jinhyun Kim, Yukio Yamamoto, Keiko Tanaka-Yamamoto
    eLife.2022;[Epub]     CrossRef
  • Repeated Restraint Stress and Binge Alcohol during Adolescence Induce Long-Term Effects on Anxiety-like Behavior and the Expression of the Endocannabinoid System in Male Rats
    Laura Sánchez-Marín, María Flores-López, Ana L. Gavito, Juan Suárez, Francisco Javier Pavón-Morón, Fernando Rodríguez de Fonseca, Antonia Serrano
    Biomedicines.2022; 10(3): 593.     CrossRef
  • “Sibling” battle or harmony: crosstalk between nesfatin-1 and ghrelin
    Xi Chen, Jing Dong, Qian Jiao, Xixun Du, Mingxia Bi, Hong Jiang
    Cellular and Molecular Life Sciences.2022;[Epub]     CrossRef
  • Pharmacological Enhancement of Extinction Retention in Non-stressed Adolescent Rats but Not Those Exposed to Chronic Corticosterone
    Anthea A. Stylianakis, Kathryn D. Baker, Rick Richardson
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • The effect of choline alphoscerate on non spatial memory and neuronal differentiation in a rat model of dual stress
    Hyo Jeong Yu, Ye Lin Kim, Min Jung Kim, Jung Mee Park, So Young Park, Shi Nae Park, Dong Won Yang
    Brain Research.2022; 1786: 147900.     CrossRef
  • Stress and the brain transcriptome: Identifying commonalities and clusters in standardized data from published experiments
    Adrian M. Stankiewicz, Aneta Jaszczyk, Joanna Goscik, Grzegorz R. Juszczak
    Progress in Neuro-Psychopharmacology and Biological Psychiatry.2022; 119: 110558.     CrossRef
  • Repeated restraint stress modifies fatty acid and amino acid metabolism in the mouse skin
    Yume KITAGAWA, Kaho HAYAKAWA, Daichi OIKAWA, Kazuki IKEDA, Maki IKEDA, Daiki HARADA, Mitsuhiro FURUSE
    Journal of Veterinary Medical Science.2022; 84(4): 511.     CrossRef
  • Antidiabetic Properties and Toxicological Assessment of Antidesma celebicum Miq: Ethanolic Leaves Extract in Sprague–Dawley Rats
    Raysa Y. Pratiwi, Berna Elya, Heri Setiawan, Roshamur C. Forestrania, Rizna T. Dewi, Kim Wei Chan
    Advances in Pharmacological and Pharmaceutical Sciences.2022; 2022: 1.     CrossRef
  • Proteomic and microbiota analyses of the oral cavity during psychological stress
    Durga Paudel, Yasuhiro Kuramitsu, Osamu Uehara, Tetsuro Morikawa, Koki Yoshida, Sarita Giri, Syed Taufiqul Islam, Takao Kitagawa, Tadashi Kondo, Kazuki Sasaki, Hirofumi Matsuoka, Hiroko Miura, Yoshihiro Abiko, Jon M. Jacobs
    PLOS ONE.2022; 17(5): e0268155.     CrossRef
  • Long-lasting effects of postweaning sleep deprivation on cognitive function and social behaviors in adult mice
    Boya Huang, Binhuang Sun, Rui Yang, Shihao Liang, Xinrui Li, Yi Guo, Qian Meng, Yaling Fu, Wenshuya Li, Penghui Zhao, Miao Gong, Yun Shi, Li Song, Sheng Wang, Fang Yuan, Haishui Shi
    Neuropharmacology.2022; 215: 109164.     CrossRef
  • High Housing Density-Induced Chronic Stress Diminishes Ovarian Reserve via Granulosa Cell Apoptosis by Angiotensin II Overexpression in Mice
    Jihyun Kim, Sooseong You
    International Journal of Molecular Sciences.2022; 23(15): 8614.     CrossRef
  • The effect of chronic stress and its preconditioning on spatial memory as well as hippocampal LRP1 and RAGE expression in a streptozotocin-induced rat model of Alzheimer’s disease
    Zohreh Taghadosi, Asadollah Zarifkar, Vahid Razban, Hadi Aligholi
    Metabolic Brain Disease.2022; 37(8): 2699.     CrossRef
  • Validity of the peak velocity to detect physical training improvements in athymic mice
    Maurício Beitia Kraemer, Karen Christine Silva, Camila Cunha França Kraemer, Juliana Silva Pereira, Ivan Gustavo Masseli dos Reis, Denise Gonçalves Priolli, Leonardo Henrique Dalcheco Messias
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Nicotine exposure through breastfeeding affects brain‐derived neurotrophic factor and synaptic proteins levels in the brain of stressed adult female mice
    Antonio Alves Pereira Júnior, Gabriel Estevam Santos de Amorim, Raphael Caio Tamborelli Garcia, Jéssyca Milene Ribeiro, Alessandra Oliveira Silva, Carolina Aparecida de Faria Almeida, Carla Speroni Ceron, Silvia Graciela Ruginsk, José Antunes‐Rodrigues, L
    International Journal of Developmental Neuroscience.2022; 82(8): 758.     CrossRef
  • Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy
    Tamás Gaszner, József Farkas, Dániel Kun, Balázs Ujvári, Gergely Berta, Valér Csernus, Nóra Füredi, László Ákos Kovács, Hitoshi Hashimoto, Dóra Reglődi, Viktória Kormos, Balázs Gaszner
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Abnormal expression of cortical cell cycle regulators underlying anxiety and depressive-like behavior in mice exposed to chronic stress
    Ana Paula Mendes-Silva, Thomas Damien Prevot, Mounira Banasr, Etienne Sibille, Breno Satler Diniz
    Frontiers in Cellular Neuroscience.2022;[Epub]     CrossRef
  • Chronic Inhibition of Aggressive Behavior Induces Behavioral Change in Mice
    Hiroshi Ueno, Yu Takahashi, Shinji Murakami, Kenta Wani, Tetsuji Miyazaki, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara, Enzo Emanuele
    Behavioural Neurology.2022; 2022: 1.     CrossRef
  • Korean Red Ginseng reduces chronic social defeat stress-induced mood disorders via N-methyl-D-aspartate receptor modulation in mice
    Bo-Ram Lee, Ju-Hyun Lee, Yong-Hyun Ko, Jee-Yeon Seo, Kwang-Hyun Hur, Young-Jung Kim, Seon-Kyung Kim, Seong-Eon Kim, Seok-Yong Lee, Choon-Gon Jang
    Journal of Ginseng Research.2021; 45(2): 254.     CrossRef
  • The Rap1 small GTPase is a critical mediator of the effects of stress on prefrontal cortical dysfunction
    B. A. Kermath, A. M. Vanderplow, K. J. Bjornson, E. N. Seablom, A. M. Novak, C. R. Bernhardt, M. E. Cahill
    Molecular Psychiatry.2021; 26(7): 3223.     CrossRef
  • Anxiolytic activity of Psidium guajava in mice subjected to chronic restraint stress and effect on neurotransmitters in brain
    Swati Sahoo, Prashant S. Kharkar, Niteshkumar U. Sahu, Brijesh S.
    Phytotherapy Research.2021; 35(3): 1399.     CrossRef
  • Changes in nitric oxide, carbon monoxide, hydrogen sulfide and male reproductive hormones in response to chronic restraint stress in rats
    Amira Moustafa
    Free Radical Biology and Medicine.2021; 162: 353.     CrossRef
  • Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats
    Fatma Z. Sakhri, Naoki Adachi, Sakina Zerizer, Yusuke Ohashi, Hideshi Ikemoto, Mana Tsukada, Zahia Kabouche, Tadashi Hisamitsu, Masataka Sunagawa
    Phytotherapy Research.2021; 35(4): 2074.     CrossRef
  • Restraint stress induces uterine microenvironment disorder in mice during early pregnancy through the β2-AR/cAMP/PKA pathway
    Jiayin Lu, Guanhui Liu, Zixu Wang, Jing Cao, Yaoxing Chen, Yulan Dong
    Stress.2021; 24(5): 514.     CrossRef
  • A model of negative emotional contagion between male-female rat dyads: Effects of voluntary exercise on stress-induced behavior and BDNF-TrkB signaling
    Gavin M. Meade, Lily S. Charron, Lantz W. Kilburn, Zhe Pei, Hoau-Yan Wang, Siobhan Robinson
    Physiology & Behavior.2021; 234: 113286.     CrossRef
  • Chronic stress promotes acute myeloid leukemia progression through HMGB1/NLRP3/IL-1β signaling pathway
    Na Liu, Yifan Wu, Xin Wen, Peng Li, Fei Lu, Hong Shang
    Journal of Molecular Medicine.2021; 99(3): 403.     CrossRef
  • Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice
    Jinho Kim, Yoo-Hun Suh, Keun-A Chang
    Molecular Brain.2021;[Epub]     CrossRef
  • Amelioration on oxidative stress, testosterone, and cortisol levels after administration of Vitamins C and E in albino rats with chronic variable stress
    Nanik Hidayatik, Agus Purnomo, Faisal Fikri, Muhammad Thohawi Elziyad Purnama
    Veterinary World.2021; 14(1): 137.     CrossRef
  • Decreased expression of AKAP4 and TyrPho proteins in testis, epididymis, and spermatozoa with low sexual performance of mice induced by modified CUMS
    Pannawat Choowong‐in, Jintana Sattayasai, Chanasorn Poodendaen, Sitthichai Iamsaard
    Andrologia.2021;[Epub]     CrossRef
  • Chronic Mild Unpredictable Stress and High-Fat Diet Given during Adolescence Impact Both Cognitive and Noncognitive Behaviors in Young Adult Mice
    Stephen L. P. Lippi
    Brain Sciences.2021; 11(2): 260.     CrossRef
  • Additional Assessment of Fecal Corticosterone Metabolites Improves Visual Rating in the Evaluation of Stress Responses of Laboratory Rats
    Tina Kroll, Nikola Kornadt-Beck, Angela Oskamp, David Elmenhorst, Chadi Touma, Rupert Palme, Andreas Bauer
    Animals.2021; 11(3): 710.     CrossRef
  • COVID-19 Stress and Food Intake: Protective and Risk Factors for Stress-Related Palatable Food Intake in U.S. Adults
    Jennifer R. Sadler, Gita Thapaliya, Elena Jansen, Anahys H. Aghababian, Kimberly R. Smith, Susan Carnell
    Nutrients.2021; 13(3): 901.     CrossRef
  • Effects of Long‐Term Exposure of Intermediate Frequency Magnetic Fields (20 kHz, 360 µT) on the Development, Pathological Findings, and Behavior of Female Mice
    Alexander Lerchl, Karen Drees (née Grote), Isabel Gronau, Dirk Fischer, Julia Bauch, Axel Hoppe
    Bioelectromagnetics.2021; 42(4): 309.     CrossRef
  • Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE−/− mouse model
    Ulrike Kogel, Ee Tsin Wong, Justyna Szostak, Wei Teck Tan, Francesco Lucci, Patrice Leroy, Bjoern Titz, Yang Xiang, Tiffany Low, Sin Kei Wong, Emmanuel Guedj, Nikolai V. Ivanov, Walter K. Schlage, Manuel C. Peitsch, Arkadiusz Kuczaj, Patrick Vanscheeuwijc
    Journal of Applied Toxicology.2021; 41(10): 1598.     CrossRef
  • Neuroprotective Effects of Acrocomia aculeata Pulp Oil Microcapsules on Rats Subjected to Chronic Stress
    Ana Cristina Jacobowski, Eduardo Benedetti Parisotto, Leonardo Recena Aydos, Roberta Serafim de Souza, Sandra Viveros, Ana Laura Colín-Gonzalez, Iandara Schettert Silva, Eliana Janet Sanjinez-Argandoña, Danilo Wilhelm Filho, Abel Santamaría-Del Angel, Mar
    Journal of Medicinal Food.2021; 24(10): 1068.     CrossRef
  • Chronic Sulfasalazine Treatment in Mice Induces System xc− - Independent Adverse Effects
    Lise Verbruggen, Lindsay Sprimont, Eduard Bentea, Pauline Janssen, Azzedine Gharib, Lauren Deneyer, Laura De Pauw, Olaya Lara, Hideyo Sato, Charles Nicaise, Ann Massie
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Effects of Achillea tenuifolia Lam. hydro-alcoholic extract on anxiety-like behavior and reproductive parameters in rat model of chronic restraint stress
    Y Bagheri, E Fathi, A Maghoul, S Moshtagh, K Mokhtari, A Abdollahpour, S Montazersaheb, A Bagheri
    Human & Experimental Toxicology.2021; 40(11): 1852.     CrossRef
  • Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice
    Junhel Dalanon, Sachiko Chikahisa, Tetsuya Shiuchi, Noriyuki Shimizu, Parimal Chavan, Yoshitaka Suzuki, Kazuo Okura, Hiroyoshi Séi, Yoshizo Matsuka
    Scientific Reports.2021;[Epub]     CrossRef
  • Stress Diminishes BDNF-stimulated TrkB Signaling, TrkB-NMDA Receptor Linkage and Neuronal Activity in the Rat Brain
    Siobhan Robinson, Allison S. Mogul, Elisa M. Taylor-Yeremeeva, Amber Khan, Anthony D. Tirabassi, Hoau-Yan Wang
    Neuroscience.2021; 473: 142.     CrossRef
  • Improved Training and Semen Collection Outcomes Using the Closed Box Chair for Macaques
    Lisa A. Houser, Cathy Ramsey, Fernanda M. de Carvalho, Breanna Kolwitz, Chelsey Naito, Kristine Coleman, Carol B. Hanna
    Animals.2021; 11(8): 2384.     CrossRef
  • Ethologically relevant repeated acute social stress induces maternal neglect in the lactating female mouse
    Zachary J. Rosinger, Heather S. Mayer, Jacqueline I. Geyfen, Mable K. Orser, Danielle S. Stolzenberg
    Developmental Psychobiology.2021;[Epub]     CrossRef
  • Sperm epigenetic alterations contribute to inter- and transgenerational effects of paternal exposure to long-term psychological stress via evading offspring embryonic reprogramming
    Xiaoguo Zheng, Zhenhua Li, Guishuan Wang, Hanshu Wang, Yuchuan Zhou, Xinzhi Zhao, C. Yan Cheng, Yunbo Qiao, Fei Sun
    Cell Discovery.2021;[Epub]     CrossRef
  • Involvement of Ghrelin Dynamics in Stress-Induced Eating Disorder: Effects of Sex and Aging
    Chihiro Yamada
    International Journal of Molecular Sciences.2021; 22(21): 11695.     CrossRef
  • Voluntary wheel running behaviour as a tool to assess the severity in a mouse pancreatic cancer model
    Nora Weegh, Eva Zentrich, Dietmar Zechner, Birgitta Struve, Laura Wassermann, Steven Roger Talbot, Simone Kumstel, Miriam Heider, Brigitte Vollmar, André Bleich, Christine Häger, Dragan Hrncic
    PLOS ONE.2021; 16(12): e0261662.     CrossRef
  • Chronic Restraint Stress Decreases the Excitability of Hypothalamic POMC Neuron and Increases Food Intake
    Go Eun Ha, Eunji Cheong
    Experimental Neurobiology.2021; 30(6): 375.     CrossRef
  • Protective Effect of Sphaerococcus coronopifolius Crude Extract in Combination with Bacillus Calmette-Guerin on Ligature-Induced Depression in Female Wistar Rats
    Fahima Fellah, Rédha Djenidi, Imen Chebout
    Psychiatry Investigation.2020; 17(2): 130.     CrossRef
  • Physical and Physiological Indicators of Welfare in Guinea Pigs (Cavia porcellus) Serving as Ambassador Animals
    David M. Powell, Corinne P. Kozlowski, John Clark, Alice Seyfried, Eli Baskir, Ashley D. Franklin
    Animals.2020; 10(5): 815.     CrossRef
  • 2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside Restores BDNF-TrkB and FGF2-Akt Signaling Axis to Attenuate Stress-induced Depression
    Xi-Xi Li, Yun Yu, Xiu-Yuan Lang, Cheng-Yong Jiang, Rongfeng Lan, Xiao-Yan Qin
    Neuroscience.2020; 430: 25.     CrossRef
  • Anxiolytic activity of Coriandrum sativum seeds aqueous extract on chronic restraint stressed mice and effect on brain neurotransmitters
    Swati Sahoo, S. Brijesh
    Journal of Functional Foods.2020; 68: 103884.     CrossRef
  • Vitamin C supplementation during chronic variable stress exposure modulates contractile functions of testicular artery and sperm parameters in male Wistar rats
    Shakiru Ademola Salami, Hussein Mofomosara Salahdeen, Oyinlola Toluwani Moronkola, Babatunde Adekunle Murtala, Yinusa Raji
    Middle East Fertility Society Journal.2020;[Epub]     CrossRef
  • A POMC-originated circuit regulates stress-induced hypophagia, depression, and anhedonia
    Na Qu, Yanlin He, Chunmei Wang, Pingwen Xu, Yongjie Yang, Xing Cai, Hesong Liu, Kaifan Yu, Zhou Pei, Ilirjana Hyseni, Zheng Sun, Makoto Fukuda, Yi Li, Qing Tian, Yong Xu
    Molecular Psychiatry.2020; 25(5): 1006.     CrossRef
  • Mirogabalin prevents repeated restraint stress-induced dysfunction in mice
    Takashi Iwai, Akinori Kikuchi, Misa Oyama, Shun Watanabe, Mitsuo Tanabe
    Behavioural Brain Research.2020; 383: 112506.     CrossRef
  • A Systematic Review of In Vitro and In Vivo Radio Frequency Exposure Methods
    Jared W. Hansen, Ellen M. Swartz, Jerika D. Cleveland, Sajid M. Asif, Benjamin Brooks, Benjamin D. Braaten, Daniel L. Ewert
    IEEE Reviews in Biomedical Engineering.2020; 13: 340.     CrossRef
  • Diminished ovarian reserve induced by chronic unpredictable stress in C57BL/6 mice
    Lingyun Gao, Fangui Zhao, Yang Zhang, Wenjun Wang, Qi Cao
    Gynecological Endocrinology.2020; 36(1): 49.     CrossRef
  • Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways
    Menizibeya O. Welcome, Nikos E. Mastorakis
    Pharmacological Research.2020; 157: 104769.     CrossRef
  • Anaesthetic-dependent changes in gene expression following acute and chronic exposure in the rodent brain
    Dannielle H. Upton, Kata Popovic, Roger Fulton, Michael Kassiou
    Scientific Reports.2020;[Epub]     CrossRef
  • Comparative analysis of acute and chronic stress-induced neurobehavioral alteration and liver injury in mice
    Tae Woo Oh, Kwang-Youn Kim, Hyun Ju Do, Young-Woo Kim, Kwang-Il Park
    Molecular & Cellular Toxicology.2020; 16(4): 367.     CrossRef
  • The impact of chronic stress on energy metabolism
    Michael A. van der Kooij
    Molecular and Cellular Neuroscience.2020; 107: 103525.     CrossRef
  • In vitro and in vivo studies of nanoparticles of chitosan-Pandanus tectorius fruit extract as new alternative treatment for hypercholesterolemia via Scavenger Receptor Class B type 1 pathway
    Efriyana Oksal, Inten Pangestika, Tengku Sifzizul Tengku Muhammad, Habsah Mohamad, Hermansyah Amir, Murni Nur Islamiah Kassim, Yosie Andriani
    Saudi Pharmaceutical Journal.2020; 28(10): 1263.     CrossRef
  • Behavioral, metabolic, and renal outcomes of 1-month isolation in adolescent male Dahl salt-sensitive rats
    Oksana Nikolaienko, Elena Isaeva, Vladislav Levchenko, Oleg Palygin, Alexander Staruschenko
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2020; 319(6): R684.     CrossRef
  • The Good, the Bad and the Unknown Aspects of Ghrelin in Stress Coping and Stress-Related Psychiatric Disorders
    Eva Maria Fritz, Nicolas Singewald, Dimitri De Bundel
    Frontiers in Synaptic Neuroscience.2020;[Epub]     CrossRef
  • Therapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology


    Lingyun Gao, Yang Zhang, Huangfang Xu, Fangui Zhao, Wenjun Wang
    Drug Design, Development and Therapy.2020; Volume 14: 4975.     CrossRef
  • Vitamin C protects against chronic social isolation stress-induced weight gain and depressive-like behavior in adult male rats
    Alireza Najaf Dulabi, Zeinab Shakerin, Nasrin Mehranfard, Maedeh Ghasemi
    Endocrine Regulations.2020; 54(4): 266.     CrossRef
  • Intermittent restraint-induced sympathetic activation attenuates hepatic steatosis and inflammation in a high-fat diet-fed mouse model
    Sung Bae Lee, Hyeong Geug Kim, Jin Seok Lee, Won Yong Kim, Myong Min Lee, Yun Hee Kim, Jung Ok Lee, Hyeon Soo Kim, Chang Gue Son
    American Journal of Physiology-Gastrointestinal and Liver Physiology.2019; 317(6): G811.     CrossRef
  • Involvement of Hepatic SHIP2 and PI3K/Akt Signalling in the Regulation of Plasma Insulin by Xiaoyaosan in Chronic Immobilization-Stressed Rats
    Qiuxia Pan, Jiajia Wu, Yueyun Liu, Xiaojuan Li, Jiaxu Chen
    Molecules.2019; 24(3): 480.     CrossRef
  • miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior
    Sydney Aten, Chloe E. Page, Anisha Kalidindi, Kelin Wheaton, Anzela Niraula, Jon P. Godbout, Kari R. Hoyt, Karl Obrietan
    Neuropharmacology.2019; 144: 256.     CrossRef
  • Oxytocin involves in chronic stress-evoked melanoma metastasis via β-arrestin 2-mediated ERK signaling pathway
    Haoyi Ji, Na Liu, Jing Li, Dawei Chen, Dan Luo, Qian Sun, Yingchun Yin, Yanli Liu, Bing Bu, Xiaoyang Chen, Jingxin Li
    Carcinogenesis.2019; 40(11): 1395.     CrossRef
  • Anxiolytic effects of γ-oryzanol in chronically- stressed mice are related to monoamine levels in the brain
    Salina Akter, Hiroyuki Sasaki, Kazi Rasel Uddin, Yuko Ikeda, Hiroki Miyakawa, Shigenobu Shibata
    Life Sciences.2019; 216: 119.     CrossRef
  • Resveratrol and dimethyl fumarate ameliorate testicular dysfunction caused by chronic unpredictable mild stress-induced depression in rats
    Atef Tadros Fahim, Amal Ahmed Abd El-Fattah, Nermin Abdel Hamid Sadik, Bassam Mohamed Ali
    Archives of Biochemistry and Biophysics.2019; 665: 152.     CrossRef
  • Centella asiaticaPrevents Increase of Hippocampal Tumor Necrosis Factor-αIndependently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of Chronic Stress
    Mawaddah Ar Rochmah, Ika Murti Harini, Dian Eurike Septyaningtrias, Dwi Cahyani Ratna Sari, Rina Susilowati
    BioMed Research International.2019; 2019: 1.     CrossRef
  • Stress-related over-enhancement of the hypothalamic-pituitary-adrenal axis causes experimental neurolathyrism in rats
    Kimino Minagawa, Shin-ichi Yamada, Ayano Suzuki, Saeko Ta, Toshio Kumai, Fernand Lambein, Kuniko Kusama-Eguchi
    Environmental Toxicology and Pharmacology.2019; 72: 103245.     CrossRef
  • Chronic Stress Combined with a Fructose Diet Reduces Hypothalamic Insulin Signaling and Antioxidative Defense in Female Rats
    Sanja Kovačević, Jelena Nestorov, Gordana Matić, Ivana Elaković
    Neuroendocrinology.2019; 108(4): 278.     CrossRef
  • Gut-Brain Neuroendocrine Signaling Under Conditions of Stress—Focus on Food Intake-Regulatory Mediators
    Andreas Stengel, Yvette Taché
    Frontiers in Endocrinology.2018;[Epub]     CrossRef
  • Chronic unpredictable mild stress-induced depressive-like behavior and dysregulation of brain levels of biogenic amines in Drosophila melanogaster
    Stífani Machado Araujo, Marcia Rósula Poetini, Vandreza Cardoso Bortolotto, Shanda de Freitas Couto, Franciane Cabral Pinheiro, Luana Barreto Meichtry, Francielli Polet de Almeida, Elize Aparecida Santos Musachio, Mariane Trindade de Paula, Marina Prigol
    Behavioural Brain Research.2018; 351: 104.     CrossRef
  • Melatonin attenuates chronic immobilization stress-induced muscle atrophy in rats: Influence on lactate-to-pyruvate ratios and Na+/K+ ATPase activity
    Eman S.H. Abd Allah, Ahmed M. Mahmoud
    Pathophysiology.2018; 25(4): 353.     CrossRef
  • Chronic stress effects and their reversibility on the Fallopian tubes and uterus in rats
    S. Divyashree, H. N. Yajurvedi
    Reproduction, Fertility and Development.2018; 30(2): 380.     CrossRef
  • Evidence-based severity assessment: Impact of repeated versus single open-field testing on welfare in C57BL/6J mice
    Carina Bodden, Sophie Siestrup, Rupert Palme, Sylvia Kaiser, Norbert Sachser, S. Helene Richter
    Behavioural Brain Research.2018; 336: 261.     CrossRef
  • Repeated Neck Restraint Stress Bidirectionally Modulates Excitatory Transmission in the Dentate Gyrus and Performance in a Hippocampus-dependent Memory Task
    Jadwiga Spyrka, Grzegorz Hess
    Neuroscience.2018; 379: 32.     CrossRef
  • Stress-induced strain and brain region-specific activation of LINE-1 transposons in adult mice
    Ugo Cappucci, Giulia Torromino, Assunta Maria Casale, Jeremy Camon, Fabrizio Capitano, Maria Berloco, Andrea Mele, Sergio Pimpinelli, Arianna Rinaldi, Lucia Piacentini
    Stress.2018; 21(6): 575.     CrossRef
  • The involvement of Rhopr-CRF/DH in feeding and reproduction in the blood-gorging insect Rhodnius prolixus
    Shirin Mollayeva, Ian Orchard, Angela B. Lange
    General and Comparative Endocrinology.2018; 258: 79.     CrossRef
  • Ghrelin is a persistent biomarker for chronic stress exposure in adolescent rats and humans
    Muhammad I. ul Akbar Yousufzai, Elia S. Harmatz, Mohsin Shah, Muhammad O. Malik, Ki A. Goosens
    Translational Psychiatry.2018;[Epub]     CrossRef
  • Sub-Chronic Stress Exacerbates the Pro-Thrombotic Phenotype in BDNFVal/Met Mice: Gene-Environment Interaction in the Modulation of Arterial Thrombosis
    Leonardo Sandrini, Alessandro Ieraci, Patrizia Amadio, Fabrizio Veglia, Maurizio Popoli, Francis Lee, Elena Tremoli, Silvia Barbieri
    International Journal of Molecular Sciences.2018; 19(10): 3235.     CrossRef
  • Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice
    Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Shozo Aoki, Takeshi Ishihara
    BMC Neuroscience.2018;[Epub]     CrossRef
  • Chronic stress induced duration dependent alterations in immune system and their reversibility in rats
    H.N. Sarjan, H.N. Yajurvedi
    Immunology Letters.2018; 197: 31.     CrossRef
  • Chronic stress alters adrenal clock function in a sexually dimorphic manner
    Matthew Stagl, Mary Bozsik, Christopher Karow, David Wertz, Ian Kloehn, Savin Pillai, Paul J Gasser, Marieke R Gilmartin, Jennifer A Evans
    Journal of Molecular Endocrinology.2018; 60(2): 55.     CrossRef
  • Impaired Growth Performance and Testicular Cells Apoptosis Following Restraint Stress in Adult Hypothyroid Mice
    Asif Mehfooz, Quanwei Wei, Mohamed Babo Fadlalla, Farman Ali Siyal, Kuldeep Dhama, Dagan Mao, Fangxiong Shi
    International Journal of Pharmacology.2017; 13(6): 541.     CrossRef
  • Chronic stress induced disruption of the peri-infarct neurovascular unit following experimentally induced photothrombotic stroke
    Zidan Zhao, Lin Kooi Ong, Sarah Johnson, Michael Nilsson, Frederick R Walker
    Journal of Cerebral Blood Flow & Metabolism.2017; 37(12): 3709.     CrossRef
  • Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis
    Leonie Stolz, Amin Derouiche, Kavi Devraj, Frank Weber, Robert Brunkhorst, Christian Foerch
    Journal of Neuroinflammation.2017;[Epub]     CrossRef
  • Maternal high-fat diet intensifies the metabolic response to stress in male rat offspring
    Roxana Karbaschi, Homeira Zardooz, Fariba Khodagholi, Leila Dargahi, Mina Salimi, FatemehSadat Rashidi
    Nutrition & Metabolism.2017;[Epub]     CrossRef
  • The effect of chronic noise stress on serum levels of cortisol, gonadotropins, and sexual hormones at implantation time of mice
    Alireza Shafiei, Hassan Ehteram, Hossein Akbari, Masoud Motalebi Kashani, Mandana Beigi, Javad Amini Mahabadi, Tahere Mazoochi
    Comparative Clinical Pathology.2017; 26(4): 779.     CrossRef
  • Aging rather than stress strongly influences amino acid metabolisms in the brain and genital organs of female mice
    Momoko Kodaira, Mao Nagasawa, Takeshi Yamaguchi, Hiromi Ikeda, Kimie Minaminaka, Vishwajit S. Chowdhury, Shinobu Yasuo, Mitsuhiro Furuse
    Mechanisms of Ageing and Development.2017; 162: 72.     CrossRef
  • Histone deacetylase-2 is involved in stress-induced cognitive impairment via histone deacetylation and PI3K/AKT signaling pathway modification
    Jie Wu, Cui Liu, Ling Zhang, Chun-Hui Qu, Xiao-Long Sui, Hua Zhu, Lan Huang, Yan-Feng Xu, Yun-Lin Han, Chuan Qin
    Molecular Medicine Reports.2017; 16(2): 1846.     CrossRef
  • High Hydrostatic Pressure Extract of Ginger Exerts Antistress Effects in Immobilization-Stressed Rats
    Sohee Moon, Mak-Soon Lee, Sunyoon Jung, Bori Kang, Seog-Young Kim, Seonyoung Park, Hye-Yeon Son, Chong-Tai Kim, Young-Hee Jo, In-Hwan Kim, Young Soon Kim, Yangha Kim
    Journal of Medicinal Food.2017; 20(9): 864.     CrossRef
  • Insulin, not glutamine dipeptide, reduces lipases expression and prevents fat wasting and weight loss in Walker 256 tumor-bearing rats
    Hely de Morais, Flaviane de Fatima Silva, Francemilson Goulart da Silva, Milene Ortiz Silva, Maria Fernanda Rodrigues Graciano, Maria Isabel Lovo Martins, Ângelo Rafael Carpinelli, Tânia Longo Mazucco, Roberto Barbosa Bazotte, Helenir Medri de Souza
    European Journal of Pharmacology.2017; 806: 67.     CrossRef
  • HBK-15 protects mice from stress-induced behavioral disturbances and changes in corticosterone, BDNF, and NGF levels
    Karolina Pytka, Monika Głuch-Lutwin, Magdalena Kotańska, Elżbieta Żmudzka, Magdalena Jakubczyk, Anna Waszkielewicz, Paulina Janiszewska, Maria Walczak
    Behavioural Brain Research.2017; 333: 54.     CrossRef
  • The exercise-glucocorticoid paradox: How exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels
    Chong Chen, Shin Nakagawa, Yan An, Koki Ito, Yuji Kitaichi, Ichiro Kusumi
    Frontiers in Neuroendocrinology.2017; 44: 83.     CrossRef
  • Long-term chronic stress exposure induces PCO phenotype in rat
    S Divyashree, H N Yajurvedi
    Reproduction.2016; 152(6): 765.     CrossRef
  • Vasculoprotective Effects of 3-Hydroxybenzaldehyde against VSMCs Proliferation and ECs Inflammation
    Byung Soo Kong, Soo Jung Im, Yang Jong Lee, Yoon Hee Cho, Yu Ri Do, Jung Woo Byun, Cheol Ryong Ku, Eun Jig Lee, Maria Cristina Vinci
    PLOS ONE.2016; 11(3): e0149394.     CrossRef
  • Effects of long-term chronic stress on the lymphoid organs and blood leukocytes of the rat (Rattus norvegicus)
    S. Divyashree, H.N. Sarjan, H.N. Yajurvedi
    Canadian Journal of Zoology.2016; 94(2): 137.     CrossRef
  • Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe
    Keitaro Yoshida, Yu Mimura, Ryosuke Ishihara, Hiroshi Nishida, Yuji Komaki, Tomohito Minakuchi, Tomokazu Tsurugizawa, Masaru Mimura, Hideyuki Okano, Kenji F. Tanaka, Norio Takata
    Journal of Neuroscience Methods.2016; 274: 38.     CrossRef
  • Integrated circuits and molecular components for stress and feeding: implications for eating disorders
    J. A. Hardaway, N. A. Crowley, C. M. Bulik, T. L. Kash
    Genes, Brain and Behavior.2015; 14(1): 85.     CrossRef
  • The Use of Animal Models to Decipher Physiological and Neurobiological Alterations of Anorexia Nervosa Patients
    Mathieu Méquinion, Christophe Chauveau, Odile Viltart
    Frontiers in Endocrinology.2015;[Epub]     CrossRef
  • Kososan, but not milnacipran, elicits antidepressant‐like effects in a novel psychological stress‐induced mouse model of depression
    Atsushi Hori, Naoki Ito, Tetsuro Oikawa, Toshihiko Hanawa
    Traditional & Kampo Medicine.2015; 2(1): 1.     CrossRef
  • Electroconvulsive stimulation, but not chronic restraint stress, causes structural alterations in adult rat hippocampus—A stereological study
    Mikkel V. Olesen, Gitta Wörtwein, Bente Pakkenberg
    Hippocampus.2015; 25(1): 72.     CrossRef
  • Dopamine release in the lateral hypothalamus is stimulated by α-MSH in both the anticipatory and consummatory phases of feeding
    Romain Legrand, Nicolas Lucas, Jonathan Breton, Pierre Déchelotte, Sergueï O. Fetissov
    Psychoneuroendocrinology.2015; 56: 79.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • Contrasting mechanisms by which social isolation and restraint impair healing in male mice
    Leah M. Pyter, Linglan Yang, Cassandra McKenzie, José M. da Rocha, C. Sue Carter, Bin Cheng, Christopher G. Engeland
    Stress.2014; 17(3): 256.     CrossRef
  • G Protein-Coupled Estrogen Receptor-1 Is Involved in the Protective Effect of Protocatechuic Aldehyde against Endothelial Dysfunction
    Byung Soo Kong, Yoon Hee Cho, Eun Jig Lee, Rajesh Mohanraj
    PLoS ONE.2014; 9(11): e113242.     CrossRef
Close layer
Review Articles
Adrenal gland
Role of Reactive Oxygen Species in Hypothalamic Regulation of Energy Metabolism
Sabrina Diano
Endocrinol Metab. 2013;28(1):3-5.   Published online March 25, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.1.3
  • 3,812 View
  • 42 Download
  • 20 Crossref
AbstractAbstract PDFPubReader   

To understand the etiology of metabolic disorders, including obesity and type II diabetes, it is essential to gain better insight into how stored and available energy sources are monitored by the central nervous system. In particular, a comprehension of the fine cellular interplay and intracellular mechanisms that enable appropriate hypothalamic and consequent endocrine and behavioral responses to both circulating hormonal and nutrient signals remains elusive. Recent data, including those from our laboratories, raised the notion that reactive oxygen species (ROS) generation is not merely a by-product of substrate oxidation, but it plays a crucial role in modulating cellular responses involved in the regulation of energy metabolism. These review summarizes the published recent data on the effect of ROS levels in the regulation of neuronal function, including that of hypothalamic melanocortin neurons, pro-opiomelanocortin and neuropeptide Y-/agouti related peptide-neurons, in the modulation of food intake.

Citations

Citations to this article as recorded by  
  • Overexpression of PpmTERF18 enhances the antioxidant capacity of peach fruit to alleviate oxidative damage
    Xiaoshan Guo, Guangqin Jing, Shuhua Zhu, Jianrong Feng, Dandan Huang
    Scientia Horticulturae.2023; 318: 112123.     CrossRef
  • Insights into the promising prospect of pharmacological approaches targeting mitochondrial dysfunction in major human diseases: At a glance
    Md.Mominur Rahman, Md.Taslim Sarker, Sabbir Ahmed, Md.Nur Uddin, Md.Shariful Islam, Md.Rezaul Islam, Shanto Das, Nobendu Mukherjee, Hassan A. Hemeg, Abdur Rauf, Bimal Kumar Ghimire, Muthu Thiruvengadam
    Process Biochemistry.2023; 132: 41.     CrossRef
  • Structure-based analysis and rational design of human peroxiredoxin-1's C-terminus-derived peptides to target sulfiredoxin-1 in pancreatic cancer
    Xiaoqiong Wu, Rongyuan Qiu, Wei Yi, Juan Chen, Zhou Zhang, Ji Zhang, Zhiyuan Zhu
    Biophysical Chemistry.2022; 288: 106857.     CrossRef
  • Drp1 is required for AgRP neuronal activity and feeding
    Sungho Jin, Nal Ae Yoon, Zhong-Wu Liu, Jae Eun Song, Tamas L Horvath, Jung Dae Kim, Sabrina Diano
    eLife.2021;[Epub]     CrossRef
  • Mechanism of deoxynivalenol mediated gastrointestinal toxicity: Insights from mitochondrial dysfunction
    Shuai Wang, Kuntan Wu, Dongfang Xue, Cong Zhang, Shahid Ali Rajput, Desheng Qi
    Food and Chemical Toxicology.2021; 153: 112214.     CrossRef
  • Redox Signaling from and to Peroxisomes: Progress, Challenges, and Prospects
    Marc Fransen, Celien Lismont
    Antioxidants & Redox Signaling.2019; 30(1): 95.     CrossRef
  • The melanocortin pathway and control of appetite-progress and therapeutic implications
    Giulia Baldini, Kevin D Phelan
    Journal of Endocrinology.2019; 241(1): R1.     CrossRef
  • Melanocortin Receptor 4 Signaling Regulates Vertebrate Limb Regeneration
    Mengshi Zhang, Youwei Chen, Hanqian Xu, Li Yang, Feng Yuan, Lei Li, Ying Xu, Ying Chen, Chao Zhang, Gufa Lin
    Developmental Cell.2018; 46(4): 397.     CrossRef
  • Hypothalamic Mitochondrial Dysfunction as a Target in Obesity and Metabolic Disease
    Juan Cunarro, Sabela Casado, Javier Lugilde, Sulay Tovar
    Frontiers in Endocrinology.2018;[Epub]     CrossRef
  • Role of oxidative stress and antioxidants in daily nutrition and human health
    Geir Bjørklund, Salvatore Chirumbolo
    Nutrition.2017; 33: 311.     CrossRef
  • DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons
    Anna Santoro, Michela Campolo, Chen Liu, Hiromi Sesaki, Rosaria Meli, Zhong-Wu Liu, Jung Dae Kim, Sabrina Diano
    Cell Metabolism.2017; 25(3): 647.     CrossRef
  • Administration of a leptin antagonist during the neonatal leptin surge induces alterations in the redox and inflammatory state in peripubertal /adolescent rats
    Virginia Mela, Oskarina Hernandez, Caroline Hunsche, Francisca Diaz, Julie A. Chowen, Mónica De la Fuente
    Molecular and Cellular Endocrinology.2017; 454: 125.     CrossRef
  • Effects of chlorogenic acid on intracellular calcium regulation in lysophosphatidylcholine-treated endothelial cells
    Hye-Jin Jung, Seung-Soon Im, Dae-Kyu Song, Jae-Hoon Bae
    BMB Reports.2017; 50(6): 323.     CrossRef
  • Trimetazidine attenuates pressure overload-induced early cardiac energy dysfunction via regulation of neuropeptide Y system in a rat model of abdominal aortic constriction
    Ailan Chen, Wanglin Li, Xinyu Chen, Yuechun Shen, Wenjun Dai, Qi Dong, Xinchun Li, Caiwen Ou, Minsheng Chen
    BMC Cardiovascular Disorders.2016;[Epub]     CrossRef
  • Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages
    Seung-Jae Kim, Ji-Young Cha, Hye Suk Kang, Jae-Ho Lee, Ji Yoon Lee, Jae-Hyung Park, Jae-Hoon Bae, Dae-Kyu Song, Seung-Soon Im
    BMB Reports.2016; 49(5): 276.     CrossRef
  • The sulfiredoxin–peroxiredoxin (Srx–Prx) axis in cell signal transduction and cancer development
    Murli Mishra, Hong Jiang, Lisha Wu, Hedy A. Chawsheen, Qiou Wei
    Cancer Letters.2015; 366(2): 150.     CrossRef
  • Effects of methanolic extracts of edible plants on RAGE in high-glucose-induced human endothelial cells
    Mizue Okada, Yoshinori Okada
    Bio-Medical Materials and Engineering.2015; 25(3): 257.     CrossRef
  • Reactive oxygen species are physiological mediators of the noradrenergic signaling pathway in the mouse supraoptic nucleus
    Ronald St-Louis, Caroline Parmentier, Valérie Grange-Messent, Sakina Mhaouty-Kodja, Hélène Hardin-Pouzet
    Free Radical Biology and Medicine.2014; 71: 231.     CrossRef
  • Reactive oxygen species play a role in muscle wasting during thyrotoxicosis
    Sara Santos Bernardes, Flávia Alessandra Guarnier, Poliana Camila Marinello, André Armani, Andréa Name Colado Simão, Rubens Cecchini, Alessandra Lourenço Cecchini
    Cell and Tissue Research.2014; 357(3): 803.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
Close layer
Neuroendocrine Regulation of Energy Metabolism.
Marcelo O Dietrich, Tamas L Horvath
Endocrinol Metab. 2012;27(4):268-273.   Published online December 20, 2012
DOI: https://doi.org/10.3803/EnM.2012.27.4.268
  • 2,258 View
  • 25 Download
  • 1 Crossref
AbstractAbstract PDF
Significant advancements have been made in the past century regarding the neuronal control of feeding behavior and energy expenditure. The effects and mechanisms of action of various peripheral metabolic signals on the brain have become clearer. Molecular and genetic tools for visualizing and manipulating individual components of brain homeostatic systems in combination with neuroanatomical, electrophysiological, behavioral, and pharmacological techniques have begun to elucidate the molecular and neuronal mechanisms of complex feeding behavior and energy expenditure. This review article highlights some of these advancements that have led to the current understanding of the brain's involvement in the acute and chronic regulation of energy homeostasis.

Citations

Citations to this article as recorded by  
  • Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans
    Laetitia Chauve, Francesca Hodge, Sharlene Murdoch, Fatemeh Masoudzadeh, Harry-Jack Mann, Andrea F. Lopez-Clavijo, Hanneke Okkenhaug, Greg West, Bebiana C. Sousa, Anne Segonds-Pichon, Cheryl Li, Steven W. Wingett, Hermine Kienberger, Karin Kleigrewe, Mari
    PLOS Biology.2021; 19(11): e3001431.     CrossRef
Close layer
Original Article
Changes in Hypothalamic-pituitary-growth Hormone (GH) Axis by Fasting: Study on the Differences between Male and Female Rats.
Sookjin Sohn, Mina Lee, Seungjoon Park
J Korean Endocr Soc. 2002;17(4):473-485.   Published online August 1, 2002
  • 900 View
  • 19 Download
AbstractAbstract PDF
BACKGROUND
Fasting has a profound impact on GH synthesis, and is released in all mammalian species that have been studied. The male rat has long been used as a model to determine the mechanism on how fasting mediates these changes. However, many aspects of GH synthesis, release and function are known to be gender-dependent. This study was conducted in order to determine if changes in the GH-axis, in response to fasting, differs between the sexes. METHODS: Male and female rats (8~9 weeks; n=5/group) were fasted for 72h, or supplied food ad libitum. The mean circulating serum GH and IGF-I concentrations were measured by radioimmunoassay. The levels of hypothalamic GH-releasing hormone (GHRH), somatostatin (SRIF), neuropeptide Y (NPY) and pituitary GH mRNA were measured using an RNase protection assay. The levels of pituitary GHRH receptor (GHRH-R), GH secretagogue (GHS) receptor (GHS-R) and SRIF receptor (sst1-5) mRNA were measured by reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: Fasting resulted in a comparable weight loss in both the males and the females, (18.0+/-0.9%) and (17.0 0.8%), respectively. In the fasted males, there was a characteristic decrease in the serum GH (98 60 vs. 7 4 ng/mL) and IGF-I (367 35 vs 152 12 ng/mL), associated with a decrease in the hypothalamic GHRH, and an increase in the NPY mRNA, levels of 52 6% and 138 6%, respectively, compared to those of the fed controls (p<0.05). In spite of the reduction in the GHRH, fasting did not alter the levels of the pituitary GH mRNA, and in fact increased the expression of the pituitary receptors, GHRH-R and GHS-R, to 185 15 and 169 25%, respectively, to those of the fed controls. In contrast to the positive impact of fasting on the GH-stimulatory receptors, fasting led to a dramatic decrease in the expressions of the somatostatin receptor subtypes, sst2 (29+/-5% of Fed) and sst4 (60+/-7% of Fed). Fasting had comparable effects on the GH-axis of the female rats, with two notable exceptions; first, fasting did not suppress the mean circulating GH levels (16 3 vs. 38 28 ng/mL) and second, did not alter the sst2 and sst4 expressions. CONCLUSION: These results corroborate the other reports regarding the effects of fasting on the expressions of hypothalamic neuropeptides, pituitary GHRH-R and sst2, in male rats. This is the first report demonstrating that fasting stimulates the expression of pituitary GHS-R in both sexes. This is of great interest given the fact that ghrelin, the putative GHS-R ligand, is also elevated by fasting. We propose that the upregulation of both ghrelin and GHS-R may play important roles in increasing the sensitivity of the pituitary to GHRH, in that these GH-stimulatory systems work synergistically. These changes may compensate for the fasting-induced suppression of hypothalamic GHRH input. We might speculate that such compensatory mechanisms are dominant in the female rat, in that circulating GH levels are not suppressed by fasting.
Close layer

Endocrinol Metab : Endocrinology and Metabolism