Gonadotropin-releasing hormone (GnRH) agonist has been used in the treatment of a wide variety of sex-hormone-related diseases, as the administration of GnRH agonist can alter the secretion of gonadotropin and sex hormones. Recently, we found that the long-acting GnRH agonist aggravated hyperthyroidism and induced painless thyroiditis. This is the first report to demonstrate the association of thyroid dysfunction with GnRH agonist injection in Korea. Here, we report three cases and emphasize the clinical importance of this aggravating factor in autoimmune thyroid disease.

Citations

Citations to this article as recorded by  

• Thyroid Dysfunction after Gonadotropin-Releasing Hormone Agonist Administration in Women with Thyroid Autoimmunity
  Loris Marin, Guido Ambrosini, Marco Noventa, Flavia Filippi, Eugenio Ragazzi, Francesco Dessole, Giampiero Capobianco, Alessandra Andrisani, Alexander Schreiber
  International Journal of Endocrinology.2022; 2022: 1.     CrossRef
• Effects of controlled ovarian stimulation on thyroid function during pregnancy
  Lingfei Li, Ling Li, Ping Li
  Biology of Reproduction.2022; 107(6): 1376.     CrossRef
• Is gonadotropin-releasing hormone agonist usage really leading to thyroid dysfunction?
  Nafiye Yilmaz, Necati Hancerliogullari, Mustafa Kara, Yaprak Engin-Ustun
  Interventional Medicine and Applied Science.2020; 11(3): 136.     CrossRef
• FANCA Polymorphism Is Associated with the Rate of Proliferation in Uterine Leiomyoma in Korea
  Eunyoung Ha, Seungmee Lee, So Min Lee, Jeeyeon Jung, Hyewon Chung, Eunsom Choi, Sun Young Kwon, Min Ho Cha, So-Jin Shin
  Journal of Personalized Medicine.2020; 10(4): 228.     CrossRef
• Effects of controlled ovarian stimulation on thyroid stimulating hormone in infertile women
  Yuan-Jie Du, Xin Xin, Na Cui, Lei Jiang, Ai-Min Yang, Gui-Min Hao, Bu-Lang Gao
  European Journal of Obstetrics & Gynecology and Reproductive Biology.2019; 234: 207.     CrossRef
• Myxedema Coma Following the Administration of Gonadotropin-releasing Hormone Agonist Complicated by Acute Pancreatitis
  Naoki Gocho, Ema Aoki, Chiho Okada, Takeshi Hirashima
  Internal Medicine.2018; 57(21): 3117.     CrossRef
• The impact of thyroid autoimmunity on IVF/ICSI outcome: a systematic review and meta-analysis
  Andrea Busnelli, Alessio Paffoni, Luigi Fedele, Edgardo Somigliana
  Human Reproduction Update.2016; 22(6): 775.     CrossRef
• The Potential Role of GnRH Agonists and Antagonists in Inducing Thyroid Physiopathological Changes During IVF
  Salvatore Gizzo, Marco Noventa, Michela Quaranta, Amerigo Vitagliano, Federica Esposito, Alessandra Andrisani, Roberta Venturella, Carlo Alviggi, Mario Plebani, Michele Gangemi, Giovanni Battista Nardelli, Donato D’Antona
  Reproductive Sciences.2016; 23(4): 515.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef