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5 "Dopamine"
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Obesity and Metabolism
Dopaminergic Control of the Feeding Circuit
Ja-Hyun Baik
Endocrinol Metab. 2021;36(2):229-239.   Published online April 6, 2021
DOI: https://doi.org/10.3803/EnM.2021.979
  • 8,868 View
  • 460 Download
  • 11 Web of Science
  • 13 Crossref
AbstractAbstract PDFPubReader   ePub   
There is increasing evidence demonstrating that reward-related motivational food intake is closely connected with the brain’s homeostatic system of energy balance and that this interaction might be important in the integrative control of feeding behavior. Dopamine regulates motivational behavior, including feeding behaviors, and the dopamine reward system is recognized as the most prominent system that controls appetite and motivational and emotional drives for food. It appears that the dopamine system exerts a critical role in the control of feeding behavior not only by the reward-related circuit, but also by contributing to the homeostatic circuit of food intake, suggesting that dopamine plays an integrative role across the converging circuitry of control of food intake by linking energy state-associated signals to reward-related behaviors. This review will cover and discuss up-to-date findings on the dopaminergic control of food intake by both the reward-related circuit and the homeostatic hypothalamic system.

Citations

Citations to this article as recorded by  
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    Nutrients.2024; 16(6): 879.     CrossRef
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    Francisco Alejandro Lagunas‐Rangel
    Archives of Insect Biochemistry and Physiology.2023;[Epub]     CrossRef
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    Mathilde C. C. Guillaumin, Daria Peleg-Raibstein
    Nutrients.2023; 15(5): 1095.     CrossRef
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    Aleksei G. Golubev
    Ageing Research Reviews.2022; 75: 101570.     CrossRef
  • Obesity I: Overview and molecular and biochemical mechanisms
    Robert H. Lustig, David Collier, Christopher Kassotis, Troy A. Roepke, Min Ji Kim, Etienne Blanc, Robert Barouki, Amita Bansal, Matthew C. Cave, Saurabh Chatterjee, Mahua Choudhury, Michael Gilbertson, Dominique Lagadic-Gossmann, Sarah Howard, Lars Lind,
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  • Food preferences and thyroid hormones in children and adolescents with obesity
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    Frontiers in Psychiatry.2022;[Epub]     CrossRef
  • Dopamine systems and biological rhythms: Let’s get a move on
    Qijun Tang, Dina R. Assali, Ali D. Güler, Andrew D. Steele
    Frontiers in Integrative Neuroscience.2022;[Epub]     CrossRef
  • Suprachiasmatic to paraventricular nuclei interaction generates normal food searching rhythms in mice
    Iwona Olejniczak, Benjamin Campbell, Yuan-Chen Tsai, Shiva K. Tyagarajan, Urs Albrecht, Jürgen A. Ripperger
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • THE ROLE OF CIRCADIAN REGULATION OF GHRELIN LEVELS IN PARKINSON’S DISEASE (LITERATURE REVIEW)
    Kateryna A. Tarianyk, Nataliya V. Lytvynenko, Anastasiia D. Shkodina, Igor P. Kaidashev
    Wiadomości Lekarskie.2021; 74(7): 1750.     CrossRef
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Kisspeptin Regulation of Neuronal Activity throughout the Central Nervous System
Xinhuai Liu, Allan E. Herbison
Endocrinol Metab. 2016;31(2):193-205.   Published online May 27, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.2.193
  • 5,795 View
  • 75 Download
  • 38 Web of Science
  • 37 Crossref
AbstractAbstract PDFPubReader   

Kisspeptin signaling at the gonadotropin-releasing hormone (GnRH) neuron is now relatively well characterized and established as being critical for the neural control of fertility. However, kisspeptin fibers and the kisspeptin receptor (KISS1R) are detected throughout the brain suggesting that kisspeptin is involved in regulating the activity of multiple neuronal circuits. We provide here a review of kisspeptin actions on neuronal populations throughout the brain including the magnocellular oxytocin and vasopressin neurons, and cells within the arcuate nucleus, hippocampus, and amygdala. The actions of kisspeptin in these brain regions are compared to its effects upon GnRH neurons. Two major themes arise from this analysis. First, it is apparent that kisspeptin signaling through KISS1R at the GnRH neuron is a unique, extremely potent form or neurotransmission whereas kisspeptin actions through KISS1R in other brain regions exhibit neuromodulatory actions typical of other neuropeptides. Second, it is becoming increasingly likely that kisspeptin acts as a neuromodulator not only through KISS1R but also through other RFamide receptors such as the neuropeptide FF receptors (NPFFRs). We suggest likely locations of kisspeptin signaling through NPFFRs but note that only limited tools are presently available for examining kisspeptin cross-signaling within the RFamide family of neuropeptides.

Citations

Citations to this article as recorded by  
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    Siva Prasad Panda, Adarsh Kesharwani, Gaurav Deep Singh, DSNBK Prasanth, Bhaskara Raju Vatchavai, P.V. Kamala Kumari, Sunil Kumar Panda, Sarada Prasanna Mallick
    Ageing Research Reviews.2023; 92: 102086.     CrossRef
  • Gallium-68-Labeled KISS1-54 Peptide for Mapping KISS1 Receptor via PET: Initial Evaluation in Human Tumor Cell Lines and in Tumor-Bearing Mice
    Ina Israel, Gabriele Riehl, Elke Butt, Andreas K. Buck, Samuel Samnick
    Pharmaceuticals.2023; 17(1): 44.     CrossRef
  • Kisspeptin-13 prevented the electrophysiological alterations induced by amyloid-beta pathology in rat: Possible involvement of stromal interaction molecules and pCREB
    Shima Ebrahimi Khonacha, Seyed Hamidreza Mirbehbahani, Mona Rahdar, Shima Davoudi, Mehdi Borjkhani, Fariba Khodagholi, Fereshteh Motamedi, Mahyar Janahmadi
    Brain Research Bulletin.2022; 184: 13.     CrossRef
  • Sexual Dimorphism in Kisspeptin Signaling
    Eun Bee Lee, Iman Dilower, Courtney A. Marsh, Michael W. Wolfe, Saeed Masumi, Sameer Upadhyaya, Mohammad A. Karim Rumi
    Cells.2022; 11(7): 1146.     CrossRef
  • Estradiol and progesterone-induced lordosis behavior is modulated by both the Kisspeptin receptor and melanin-concentrating hormone in estradiol benzoate-primed rats
    Oscar González-Flores, James G. Pfaus, Ailyn Luna-Hernández, Omar Montes-Narváez, Raymundo Domínguez-Ordóñez, Miriam B. Tecamachaltzi-Silvarán, Marcos García-Juárez
    Hormones and Behavior.2022; 146: 105257.     CrossRef
  • Targeting KNDy neurons to control GnRH pulses
    Stephanie Constantin
    Current Opinion in Pharmacology.2022; 67: 102316.     CrossRef
  • The ameliorative effects of Lactobacillus coagulans and Lactobacillus casei probiotics on CCl4‐induced testicular toxicity based on biochemical, histological and molecular analyses in rat
    Zahra Keshtmand, Mohsen Akbaribazm, Yasin Bagheri, Reyhaneh Oliaei
    Andrologia.2021;[Epub]     CrossRef
  • Nitric oxide resets kisspeptin-excited GnRH neurons via PIP2 replenishment
    Stephanie Constantin, Daniel Reynolds, Andrew Oh, Katherine Pizano, Susan Wray
    Proceedings of the National Academy of Sciences.2021;[Epub]     CrossRef
  • Expression analysis of neuropeptide FF receptors on neuroendocrine-related neurons in the rat brain using highly sensitive in situ hybridization
    Shimpei Higo, Moeko Kanaya, Hitoshi Ozawa
    Histochemistry and Cell Biology.2021; 155(4): 465.     CrossRef
  • Timing the Juvenile-Adult Neurohormonal Transition: Functions and Evolution
    Celia G. Barredo, Beatriz Gil-Marti, Derya Deveci, Nuria M. Romero, Francisco A. Martin
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3β signaling pathway
    Yi Huang, Yong Guo, Lei Huang, Yuanjian Fang, Dujuan Li, Rui Liu, Qin Lu, Reng Ren, Lihui Tang, Lifei Lian, Yongmei Hu, Jiping Tang, Gao Chen, John H. Zhang
    Free Radical Biology and Medicine.2021; 171: 99.     CrossRef
  • Conditioned place preference of kisspeptin-10
    Ilia Yu. Tissen, Polina A. Chepik, Andrei A. Lebedev, Leila A. Magarramova, Eugenii R. Bychkov, Petr D. Shabanov
    Reviews on Clinical Pharmacology and Drug Therapy.2021; 19(1): 47.     CrossRef
  • Expression of type one cannabinoid receptor in different subpopulation of kisspeptin neurons and kisspeptin afferents to GnRH neurons in female mice
    Tamás Wilheim, Krisztina Nagy, Mahendravarman Mohanraj, Kamil Ziarniak, Masahiko Watanabe, Joanna Sliwowska, Imre Kalló
    Brain Structure and Function.2021; 226(7): 2387.     CrossRef
  • Dopamine D2 Receptor Antagonist Alters the Testosterone Release and Kisspeptin/GPR54 Signaling in Food-Restricted Rats
    Khatereh Nourmohammadi, Farrin Babaei-Balderlou, Seyyed Meysam Abtahi-Foroushani
    Iranian Journal of Science and Technology, Transactions A: Science.2021; 45(6): 1879.     CrossRef
  • Astrocytic Hydrogen Sulfide Regulates Supraoptic Cellular Activity in the Adaptive Response of Lactating Rats to Chronic Social Stress
    Dongyang Li, Haitao Liu, Hongyang Wang, Shuwei Jia, Xiaoran Wang, Shuo Ling, Guichuan Chen, Xiaoyu Liu, Yu-Feng Wang
    ASN Neuro.2021; 13: 175909142110430.     CrossRef
  • Experimental characterization of a biosensor based on a tapered optical fiber for kisspeptin detection
    K. González-León, G. Beltrán-Pérez, S. Muñoz-Aguirre, V. López -Gayou, J. Castillo-Mixcoatl, V. Alatriste, R. Delgado-Macuil
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    Noelia P. Di Giorgio, Marianne Bizzozzero Hiriart, Pablo N. Surkin, Paula V. López, Nadia S. Bourguignon, Verónica B. Dorfman, Bernhard Bettler, Carlos Libertun, Victoria Lux‐Lantos
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    Zhu Zhu, Xiaozhen Zhao, Feng Huang, Feng Wang, Wei Wang
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  • The kisspeptin derivative kissorphin reduces the acquisition, expression, and reinstatement of ethanol-induced conditioned place preference in rats
    Ewa Gibula-Tarlowska, Pawel Grochecki, Jerzy Silberring, Jolanta H. Kotlinska
    Alcohol.2019; 81: 11.     CrossRef
  • Unraveling the connection between GABA and kisspeptin in the control of reproduction
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  • Region-specific changes in brain kisspeptin receptor expression during estrogen depletion and the estrous cycle
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    Won-Young Lee
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    Jing Zhong, Sarwat Amina, Mingkun Liang, Shirin Akther, Teruko Yuhi, Tomoko Nishimura, Chiharu Tsuji, Takahiro Tsuji, Hong-Xiang Liu, Minako Hashii, Kazumi Furuhara, Shigeru Yokoyama, Yasuhiko Yamamoto, Hiroshi Okamoto, Yong Juan Zhao, Hon Cheung Lee, Mak
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  • Role of the Kiss1/Kiss1r system in the regulation of pituitary cell function
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Original Articles
Adrenal gland
Early Prediction of Long-Term Response to Cabergoline in Patients with Macroprolactinomas
Youngki Lee, Cheol Ryong Ku, Eui-Hyun Kim, Jae Won Hong, Eun Jig Lee, Sun Ho Kim
Endocrinol Metab. 2014;29(3):280-292.   Published online September 25, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.3.280
  • 4,005 View
  • 51 Download
  • 12 Web of Science
  • 13 Crossref
AbstractAbstract PDFPubReader   
Background

Cabergoline is typically effective for treating prolactinomas; however, some patients display cabergoline resistance, and the early characteristics of these patients remain unclear. We analyzed early indicators predicting long-term response to cabergoline.

Methods

We retrospectively reviewed the cases of 44 patients with macroprolactinomas who received cabergoline as first-line treatment; the patients were followed for a median of 16 months. The influence of various clinical parameters on outcomes was evaluated.

Results

Forty patients (90.9%) were treated medically and displayed tumor volume reduction (TVR) of 74.7%, a prolactin normalization (NP) rate of 81.8%, and a complete response (CR; TVR >50% with NP, without surgery) rate of 70.5%. Most patients (93.1%) with TVR ≥25% and NP at 3 months eventually achieved CR, whereas only 50% of patients with TVR ≥25% without NP and no patients with TVR <25% achieved CR. TVR at 3 months was strongly correlated with final TVR (R=0.785). Patients with large macroadenomas exhibited a low NP rate at 3 months, but eventually achieved TVR and NP rates similar to those of patients with smaller tumors. Surgery independently reduced the final dose of cabergoline (β=-1.181 mg/week), and two of four patients who underwent surgery were able to discontinue cabergoline.

Conclusion

Determining cabergoline response using TVR and NP 3 months after treatment is useful for predicting later outcomes. However, further cabergoline administration should be considered for patients with TVR >25% at 3 months without NP, particularly those with huge prolactinomas, because a delayed response may be achieved. As surgery can reduce the cabergoline dose necessary for successful disease control, it should be considered for cabergoline-resistant patients.

Citations

Citations to this article as recorded by  
  • Resistance to dopamine agonists in the treatment of prolactinomas: diagnostic criteria, mechanisms and ways to overcome it
    Irena A. Ilovayskaya, Gulnar R. Vagapova
    Almanac of Clinical Medicine.2024; 51(7): 397.     CrossRef
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    Stephan Petersenn, Maria Fleseriu, Felipe F. Casanueva, Andrea Giustina, Nienke Biermasz, Beverly M. K. Biller, Marcello Bronstein, Philippe Chanson, Hidenori Fukuoka, Monica Gadelha, Yona Greenman, Mark Gurnell, Ken K. Y. Ho, Jürgen Honegger, Adriana G.
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    Andrius Anuzis, Kevin O. Lillehei
    Journal of Neurological Surgery Part B: Skull Base.2023;[Epub]     CrossRef
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    Xiangming Cai, Junhao Zhu, Jin Yang, Chao Tang, Zixiang Cong, Chiyuan Ma
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    Renato Cozzi, Maria Rosaria Ambrosio, Roberto Attanasio, Claudia Battista, Alessandro Bozzao, Marco Caputo, Enrica Ciccarelli, Laura De Marinis, Ernesto De Menis, Marco Faustini Fustini, Franco Grimaldi, Andrea Lania, Giovanni Lasio, Francesco Logoluso, M
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    Kyungwon Kim, Yae Won Park, Daham Kim, Sung Soo Ahn, Ju Hyung Moon, Eui Hyun Kim, Eun Jig Lee, Cheol Ryong Ku
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    Ji Yong Park, Wonsuk Choi, A Ram Hong, Jee Hee Yoon, Hee Kyung Kim, Woo-Youl Jang, Shin Jung, Ho-Cheol Kang
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    Betina Biagetti, Rafael Simò
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    Rakesh Mishra, SubhasK Konar, Adesh Shrivastava, Pradeep Chouksey, Sumit Raj, Amit Agrawal
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    Elle Vermeulen, Jean D’Haens, Tadeusz Stadnik, David Unuane, Kurt Barbe, Vera Van Velthoven, Sven Gläsker
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    Erica A. Giraldi, Adriana G. Ioachimescu
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    Won-Young Lee
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Close layer
Functional Role of Parkin against Oxidative Stress in Neural Cells
Minyoung Hwang, Ja-Myong Lee, Younghwa Kim, Dongho Geum
Endocrinol Metab. 2014;29(1):62-69.   Published online March 14, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.1.62
  • 3,388 View
  • 28 Download
  • 6 Web of Science
  • 4 Crossref
AbstractAbstract PDFPubReader   
Background

Parkinson disease (PD) is caused by selective cell death of dopaminergic neurons in the substantia nigra. An early onset form of PD, autosomal recessive juvenile parkinsonism has been associated with a mutation in the parkin gene. The function of parkin is known to remove misfolding proteins and protect cell death. We aimed to investigate the role of parkin against oxidative stress in neuronal cells.

Methods

Parkin knockout embryonic stem cells (PKO ES cells) were differentiated into neurons by adherent monolayer culture method. Oxidative stress was induced by the treatment of 1-methyl-4-phenylpyridinium (MPP+) in neurons derived from wild type and PKO ES cells, and cell viability was examined by MTT assay. After exposure to MPP+, Tuj1-positive cell population was compared between PKO and wild type cells by fluorescence activated cell sorter (FACS) analysis. The activated caspase3 protein level was also measured by Western blot analysis, FACS and immunocytochemistry.

Results

There was no difference in the efficiency of neuronal differentiation between wild type and PKO ES cells. After exposure to MPP+, no significant differences were found in cell viability and Tuj1-positive cell population between the two groups determined by MTT assay and FACS analysis, respectively. The activated caspase3 protein levels examined by Western blot analysis, FACS and immunocytochemistry were not changed in PKO cells compared with those of wild type cells after MPP+ treatment.

Conclusion

These results suggest that PKO neuronal cells including dopaminergic neurons are not sensitive to caspase3-dependent cell death pathway during the response against MPP+-induced oxidative stress.

Citations

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Case Report
A Case of Dopamine-Secreting Pheochromocytoma.
Jung Kyu Park, Hoon Kyu Oh, Moo Hyun Shon, Hyun Hee Kim, Eon Ju Jeon, Eui Dal Jung
Endocrinol Metab. 2012;27(2):159-162.   Published online June 20, 2012
DOI: https://doi.org/10.3803/EnM.2012.27.2.159
  • 65,849 View
  • 33 Download
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AbstractAbstract PDF
A pheochromocytoma is a neuroectodermal tumor that originates from the chromaffin cells of the sympathetic system. It has typical symptoms or signs, such as periodic attacks of paroxysmal hypertension, palpitation, headache, and sweating, related to an increased catecholamine secretion. Types of catecholamine secreted from tumors are usually norepinephrine and epinerphrine. There are a few reports of dopamine-secreting pheochromocytoma with absence of other catecholamines secretion. Here, we report the case of a 59-year-old man with dopamine-secreting pheochromocytoma, with no typical symptoms or signs.

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  • Metanephrine negative pheochromocytoma: a rare case report of dopamine-secreting tumor in an adolescent neurofibromatosis type 1 patient
    Mi-Seon Lee, Rosie Lee, Sook-Hyun Park, Soon Hak Kwon, Jin-Young Park, Sang-Woo Lee, So-Mi Lee, Jung-Eun Moon
    Annals of Pediatric Endocrinology & Metabolism.2023; 28(4): 302.     CrossRef
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Endocrinol Metab : Endocrinology and Metabolism