Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
1 "Cardiometabolic health"
Filter
Filter
Article type
Keywords
Publication year
Authors
Review Article
Miscellaneous
Quality Matters as Much as Quantity of Skeletal Muscle: Clinical Implications of Myosteatosis in Cardiometabolic Health
Hong-Kyu Kim, Chul-Hee Kim
Endocrinol Metab. 2021;36(6):1161-1174.   Published online December 28, 2021
DOI: https://doi.org/10.3803/EnM.2021.1348
  • 6,392 View
  • 283 Download
  • 26 Web of Science
  • 29 Crossref
AbstractAbstract PDFPubReader   ePub   
Although age-related changes in skeletal muscles are closely associated with decreases in muscle strength and functional decline, their associations with cardiometabolic diseases in the literature are inconsistent. Such inconsistency could be explained by the fact that muscle quality—which is closely associated with fatty infiltration of the muscle (i.e., myosteatosis)—is as important as muscle quantity in cardiometabolic health. However, muscle quality has been less explored compared with muscle mass. Moreover, the standard definition of myosteatosis and its assessment methods have not been established yet. Recently, some techniques using single axial computed tomography (CT) images have been introduced and utilized in many studies, as the mass and quality of abdominal muscles could be measured opportunistically on abdominal CT scans obtained during routine clinical care. Yet, the mechanisms by which myosteatosis affect metabolic and cardiovascular health remain largely unknown. In this review, we explore the recent advances in the assessment of myosteatosis and its changes associated with aging. We also review the recent literature on the clinical implication of myosteatosis by focusing on metabolic and cardiovascular diseases. Finally, we discuss the challenges and unanswered questions that need addressing to set myosteatosis as a therapeutic target for the prevention or treatment of cardiometabolic diseases.

Citations

Citations to this article as recorded by  
  • A CT-based Deep Learning Model for Predicting Subsequent Fracture Risk in Patients with Hip Fracture
    Yisak Kim, Young-Gon Kim, Jung-Wee Park, Byung Woo Kim, Youmin Shin, Sung Hye Kong, Jung Hee Kim, Young-Kyun Lee, Sang Wan Kim, Chan Soo Shin
    Radiology.2024;[Epub]     CrossRef
  • Myosteatosis is associated with poor survival after kidney transplantation: a large retrospective cohort validation
    Jie Chen, Yue Li, Chengjie Li, Turun Song
    Abdominal Radiology.2024; 49(4): 1210.     CrossRef
  • Fatty infiltration of gastrocnemius–soleus muscle complex: Considerations for myosteatosis rehabilitation
    Catherine Hatzantonis, Lalith Satkunam, Karyne N. Rabey, Jennifer C. Hocking, Anne M. R. Agur
    Journal of Anatomy.2024;[Epub]     CrossRef
  • Muscle attenuation, not skeletal muscle index, is an independent prognostic factor for survival in gastric cancer patients with overweight and obesity
    Cheng-Le Zhuang, Hao-Fan Wu, Hao-Jie Jiang, Feng-Min Zhang, Han-Ping Shi, Zhen Yu, Xian Shen, Xiao-Lei Chen, Su-Lin Wang
    Nutrition.2024; 122: 112391.     CrossRef
  • Myosteatosis is associated with coronary artery calcification in patients with type 2 diabetes
    Fu-Peng Liu, Mu-Jie Guo, Qing Yang, Yan-Ying Li, Yan-Gang Wang, Mei Zhang
    World Journal of Diabetes.2024; 15(3): 429.     CrossRef
  • Unlocking liver health: Can tackling myosteatosis spark remission in metabolic dysfunction‐associated steatotic liver disease?
    Guillaume Henin, Audrey Loumaye, Louise Deldicque, Isabelle A. Leclercq, Nicolas Lanthier
    Liver International.2024;[Epub]     CrossRef
  • Association of serum gamma-glutamyl transferase with myosteatosis assessed by muscle quality mapping using abdominal computed tomography
    Han Na Jung, Yun Kyung Cho, Hwi Seung Kim, Eun Hee Kim, Min Jung Lee, Joong-Yeol Park, Woo Je Lee, Hong-Kyu Kim, Chang Hee Jung
    Clinical Imaging.2023; 93: 4.     CrossRef
  • Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of cardiometabolic diseases in a Chinese natural population: A cross‐sectional study
    Shi Zhang, Yaping Huang, Jing Li, Xincheng Wang, Xiaohe Wang, Minying Zhang, Yanju Zhang, Meiyang Du, Jingna Lin, Chunjun Li
    Diabetes/Metabolism Research and Reviews.2023;[Epub]     CrossRef
  • Association between hypertension and myosteatosis evaluated by abdominal computed tomography
    Han Na Jung, Yun Kyung Cho, Hwi Seung Kim, Eun Hee Kim, Min Jung Lee, Woo Je Lee, Hong-Kyu Kim, Chang Hee Jung
    Hypertension Research.2023; 46(4): 845.     CrossRef
  • Epidemiological, mechanistic, and practical bases for assessment of cardiorespiratory fitness and muscle status in adults in healthcare settings
    Jaime A. Gallo-Villegas, Juan C. Calderón
    European Journal of Applied Physiology.2023; 123(5): 945.     CrossRef
  • Muscle fat infiltration in chronic kidney disease: a marker related to muscle quality, muscle strength and sarcopenia
    Carla Maria Avesani, Aline Miroski de Abreu, Heitor S. Ribeiro, Torkel B. Brismar, Peter Stenvinkel, Alice Sabatino, Bengt Lindholm
    Journal of Nephrology.2023; 36(3): 895.     CrossRef
  • IDF2022-1139 Association Between Dyslipidemia And Myosteatosis Using Visual Muscular Quality Map In Computed Tomography
    H.S. Kim, H.N. Jung, Y.K. Cho, E.H. Kim, M.J. Lee, W.J. Lee, J.Y. Park, H.K. Kim, C.H. Jung
    Diabetes Research and Clinical Practice.2023; 197: 110467.     CrossRef
  • The role of skeletal muscle mass on cardiovascular disease risk: an emerging role on modulating lipid profile
    Evangelia Damigou, Matina Kouvari, Demosthenes Panagiotakos
    Current Opinion in Cardiology.2023; 38(4): 352.     CrossRef
  • Reference values for low muscle mass and myosteatosis using tomographic muscle measurements in living kidney donors
    Lisa B. Westenberg, Marcel Zorgdrager, Tim D. A. Swaab, Marco van Londen, Stephan J. L. Bakker, Henri G. D. Leuvenink, Alain R. Viddeleer, Robert A. Pol
    Scientific Reports.2023;[Epub]     CrossRef
  • Association between sarcopenic obesity and poor muscle quality based on muscle quality map and abdominal computed tomography
    Yun Kyung Cho, Han Na Jung, Eun Hee Kim, Min Jung Lee, Joong‐Yeol Park, Woo Je Lee, Hong‐Kyu Kim, Chang Hee Jung
    Obesity.2023; 31(6): 1547.     CrossRef
  • Increase in skeletal muscular adiposity and cognitive decline in a biracial cohort of older men and women
    Caterina Rosano, Anne Newman, Adam Santanasto, Xiaonan Zhu, Bret Goodpaster, Iva Miljkovic
    Journal of the American Geriatrics Society.2023; 71(9): 2759.     CrossRef
  • Evaluation of Paraspinal Muscle Degeneration on Pain Relief after Percutaneous Epidural Adhesiolysis in Patients with Degenerative Lumbar Spinal Disease
    Misun Kang, Shin Hyung Kim, Minju Jo, Hyun Eom Jung, Jungbin Bae, Hee Jung Kim
    Medicina.2023; 59(6): 1118.     CrossRef
  • Sarcopenic obesity and its relation with muscle quality and mortality in patients on chronic hemodialysis
    Alice Sabatino, Carla Maria Avesani, Giuseppe Regolisti, Marianna Adinolfi, Giuseppe Benigno, Marco Delsante, Enrico Fiaccadori, Ilaria Gandolfini
    Clinical Nutrition.2023; 42(8): 1359.     CrossRef
  • Association between computed tomography‐assessed sarcopenia and mortality in patients with anti‐neutrophil cytoplasmic antibody‐associated vasculitis
    Sung Soo Ahn, Yong‐Beom Park, Sang‐Won Lee
    International Journal of Rheumatic Diseases.2023; 26(9): 1704.     CrossRef
  • Association Between Insulin Resistance and Myosteatosis Measured by Abdominal Computed Tomography
    Myung Jin Kim, Yun Kyung Cho, Han Na Jung, Eun Hee Kim, Min Jung Lee, Chang Hee Jung, Joong-Yeol Park, Hong-Kyu Kim, Woo Je Lee
    The Journal of Clinical Endocrinology & Metabolism.2023; 108(12): 3100.     CrossRef
  • Association of Visceral Fat Obesity, Sarcopenia, and Myosteatosis with Non-Alcoholic Fatty Liver Disease without Obesity
    Hong-Kyu Kim, Sung-Jin Bae, Min Jung Lee, Eun Hee Kim, Hana Park, Hwi Seung Kim, Yun Kyung Cho, Chang Hee Jung, Woo Je Lee, Jaewon Choe
    Clinical and Molecular Hepatology.2023; 29(4): 987.     CrossRef
  • Different computed tomography parameters for defining myosteatosis in patients with advanced non-small cell lung cancer
    Wenyi Zhang, Jing Tang, Huiyu Tang, Lingling Xie, Jing Wang, Jinhui Wu, Ming Yang
    Clinical Nutrition.2023; 42(12): 2414.     CrossRef
  • All you need to know about sarcopenia: a short guide for an internal medicine physician in questions and answers
    G. R. Bikbavova, M. A. Livzan, D. V. Tikhonravova
    Bulletin of Siberian Medicine.2023; 22(3): 88.     CrossRef
  • Muscle Fat Content Is Associated with Nonalcoholic Fatty Liver Disease and Liver Fibrosis in Chinese Adults
    W. Guo, X. Zhao, D. Cheng, X. Liang, M. Miao, X. Li, J. Lu, N. Xu, Shuang Hu, Qun Zhang
    The Journal of nutrition, health and aging.2023; 27(11): 960.     CrossRef
  • Body Composition Evaluation and Clinical Markers of Cardiometabolic Risk in Patients with Phenylketonuria
    Luis M. Luengo-Pérez, Mercedes Fernández-Bueso, Ana Ambrojo, Marta Guijarro, Ana Cristina Ferreira, Luís Pereira-da-Silva, André Moreira-Rosário, Ana Faria, Conceição Calhau, Anne Daly, Anita MacDonald, Júlio César Rocha
    Nutrients.2023; 15(24): 5133.     CrossRef
  • Assessment of Muscle Quantity, Quality and Function
    Bo Kyung Koo
    Journal of Obesity & Metabolic Syndrome.2022; 31(1): 9.     CrossRef
  • Influence of cross‐sectional area and fat infiltration of paraspinal muscles on analgesic efficacy of epidural steroid injection in elderly patients
    Hee Jung Kim, Miribi Rho, Kyung Bong Yoon, Minju Jo, Dong Woo Lee, Shin Hyung Kim
    Pain Practice.2022; 22(7): 621.     CrossRef
  • Sarcopenia, Obesity, Sarcopenic Obesity and Risk of Poor Nutritional Status in Polish Community-Dwelling Older People Aged 60 Years and Over
    Marika Murawiak, Roma Krzymińska-Siemaszko, Aleksandra Kaluźniak-Szymanowska, Marta Lewandowicz, Sławomir Tobis, Katarzyna Wieczorowska-Tobis, Ewa Deskur-Śmielecka
    Nutrients.2022; 14(14): 2889.     CrossRef
  • Metabolic mechanisms for and treatment of NAFLD or NASH occurring after liver transplantation
    Amedeo Lonardo, Alessandro Mantovani, Salvatore Petta, Amedeo Carraro, Christopher D. Byrne, Giovanni Targher
    Nature Reviews Endocrinology.2022; 18(10): 638.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism