Endocrinology and Metabolism

Original Articles

Clinical Study
Association between Bsm1 Polymorphism in Vitamin D Receptor Gene and Diabetic Retinopathy of Type 2 Diabetes in Korean Population: Yong Joo Hong, Eun Seok Kang, Myoung Jin Ji, Hyung Jin Choi, Taekeun Oh, Sung-Soo Koong, Hyun Jeong Jeon; Endocrinol Metab. 2015;30(4):469-474. Published online December 31, 2015; DOI: https://doi.org/10.3803/EnM.2015.30.4.469

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Background

Type 2 diabetes is one of the most common diseases with devastating complications. However, genetic susceptibility of diabetic complications has not been clarified. The vitamin D endocrine system is related with calcification and lipolysis, insulin secretion, and may be associated with many complicated disease including diabetes and cardiovascular disease. Recent studies reported that single nucleotide polymorphisms of vitamin D receptor (VDR) gene were associated with diabetic complications.

Methods

In present study, we evaluated the association of BsmI polymorphism of VDR with diabetic complications in Korean diabetes patients. Total of 537 type 2 diabetic subjects from the Endocrinology Clinic of Chungbuk National University Hospital were investigated. Polymerase chain reaction-restriction fragment length polymorphism was used to test the genotype and allele frequency of BsmI (rs1544410; BB, Bb, bb) polymorphisms.

Results

Mean age was 62.44±10.64 years and mean disease duration was 13.65±7.39 years. Patients with B allele (BB or Bb) was significantly associated with lower risk of diabetic retinopathy (severe non-proliferative diabetic retinopathy or proliferative retinopathy; 7.4%, 5/68) compared with patients without B allele (bb; 17.3%, 81/469; P=0.035). This association was also significant after adjusting for hemoglobin A1c level, body mass index, age, sex, and diabetes mellitus duration, concurrent dyslipidemia and hypertension (odds ratio, 2.99; 95% confidence interval, 1.08 to 8.29; P=0.035) in logistic regression analysis.

Conclusion

Our findings suggest that B allele of Bsm1 polymorphism in VDR gene is associated with lower risk of diabetic retinopathy in type 2 diabetic patients. Bsm1 genotype could be used as a susceptibility marker to predict the risk of diabetes complication.

Citations

Citations to this article as recorded by

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A.N. Rizza, Nethra Lenin, Yazhini Ramaswamy, Deepak Kumar Sundaramoorthy, Rajiv Raman, Sinnakaruppan Mathavan
Human Gene.2025; 43: 201362. CrossRef
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Mehar Darukhshan Kalim, Sachidananda Behera, Niyamat Ali Siddiqui, Krishna Pandey, Vahab Ali
Microbial Pathogenesis.2025; 205: 107706. CrossRef
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Serkan YILDIZ, Serbülent YİĞİT, Ayşe Feyda NURSAL, Nevin KARAKUŞ, Mehmet Kemal TÜMER
ADO Klinik Bilimler Dergisi.2024; 13(1): 100. CrossRef
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Pramod Kumar Sahu, Priyanka Gautam, Gopal Krushna Das, Priyanka Gogoi, Nitika Beri, Rahul Bhatia
Journal of Family Medicine and Primary Care.2024; 13(8): 3298. CrossRef
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Nilufer Kuruca, Aynur Atilla, Muhammed Taha Kaya, Sedat Gokmen, Ayse Feyda Nursal, Ozgur Kilic, Tuba Kuruoglu, Fatih Temocin, Tolga Guvenc, Serbulent Yigit, Dilek Guvenc
Journal of Investigative Medicine.2024; 72(8): 876. CrossRef
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Claudia Elena Petrea, Laura Andreea Ghenciu, Roxana Iacob, Emil Robert Stoicescu, Dorel Săndesc
Biomedicines.2024; 13(1): 68. CrossRef
Association analysis between the VDR gene variants and type 2 diabetes
Shabnam Salehizadeh, Sara Ramezani, Mojgan Asadi, Mahdi Afshari, Seyed Hamid Jamaldini, Farhad Adhami Moghadam, Mandana Hasanzad
Journal of Diabetes & Metabolic Disorders.2023; 23(1): 633. CrossRef
Metabolic impact of the VDR rs1544410 in diabetic retinopathy
Caroline Severo de Assis, Tainá Gomes Diniz, João Otávio Scarano Alcântara, Vanessa Polyana Alves de Sousa Brito, Rayner Anderson Ferreira do Nascimento, Mayara Karla dos Santos Nunes, Alexandre Sérgio Silva, Isabella Wanderley de Queiroga Evangelista, Ma
PLOS ONE.2022; 17(2): e0263346. CrossRef
Vitamin D, the Vitamin D Receptor, Calcitriol Analogues and Their Link with Ocular Diseases
Miłosz Caban, Urszula Lewandowska
Nutrients.2022; 14(11): 2353. CrossRef
Vitamin D-Related Single Nucleotide Polymorphisms as Risk Biomarker of Cardiovascular Disease
Paula González Rojo, Cristina Pérez Ramírez, José María Gálvez Navas, Laura Elena Pineda Lancheros, Susana Rojo Tolosa, María del Carmen Ramírez Tortosa, Alberto Jiménez Morales
International Journal of Molecular Sciences.2022; 23(15): 8686. CrossRef
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Journal of Personalized Medicine.2022; 12(9): 1488. CrossRef
Relation of vitamin D and BsmI variant with temporomandibular diseases in the Turkish population
S. Yildiz, M.K. Tumer, S. Yigit, A.F. Nursal, A. Rustemoglu, Y. Balel
British Journal of Oral and Maxillofacial Surgery.2021; 59(5): 555. CrossRef
The relationship between vitamin D receptor (VDR) rs2228570 and rs7975232 genetic variants and the risk of recurrent pregnancy loss
Zohreh Salari, Nasrollah Saleh-Gohari, Monire Rezapour, Ahamad Khosravi, Hadi Tavakkoli, Ehsan Salarkia, Fatemeh Karami-Robati
Meta Gene.2021; 27: 100833. CrossRef
Association of Bone Metabolism Indices and Bone Mineral Density with Diabetic Retinopathy in Elderly Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Inpatient Study in China
Xin Zhao, Lili Huo, Xiaofeng Yu, Xiaomei Zhang, Fabio Vescini
Journal of Diabetes Research.2021; 2021: 1. CrossRef
The Associations Between Vitamin D Receptor BsmI and ApaI Polymorphisms and Obesity in Korean Patients with Type 2 Diabetes Mellitus
Sang Won Nam, Jinwoo Choi, Hyun Jeong Jeon, Tae Keun Oh, Dong-Hwa Lee
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 557. CrossRef
Vitamin D Deficiency at Mid-Pregnancy Is Associated with a Higher Risk of Postpartum Glucose Intolerance in Women with Gestational Diabetes Mellitus
Kyung-Soo Kim, Seok Won Park, Yong-Wook Cho, Soo-Kyung Kim
Endocrinology and Metabolism.2020; 35(1): 97. CrossRef
The role of vitamin D in the pathogenesis and treatment of diabetes mellitus: a narrative review
Maria Grammatiki, Spiros Karras, Kalliopi Kotsa
Hormones.2019; 18(1): 37. CrossRef
Vitamin D-binding protein and vitamin D receptor genotypes and 25-hydroxyvitamin D levels are associated with development of aortic and mitral valve calcification and coronary artery diseases
Amir Kiani, Ehsan Mohamadi-Nori, Asad Vaisi-Raygani, Maryam Tanhapour, Said Elahi-Rad, Fariborz Bahrehmand, Zohreh Rahimi, Tayebeh Pourmotabbed
Molecular Biology Reports.2019; 46(5): 5225. CrossRef
Is Hypovitaminosis D Related to Incidence of Type 2 Diabetes and High Fasting Glucose Level in Healthy Subjects: A Systematic Review and Meta-Analysis of Observational Studies
Shamaila Rafiq, Per Jeppesen
Nutrients.2018; 10(1): 59. CrossRef
Association between the vitaminDreceptor gene polymorphisms and diabetic nephropathy risk:Ameta‐analysis
Fang Yin, Jing Liu, Ming‐Xiu Fan, Xiao‐Li Zhou, Xiao‐Ling Zhang
Nephrology.2018; 23(2): 107. CrossRef
BSMI single nucleotide polymorphism in vitamin D receptor gene is associated with decreased circulatory levels of serum 25-hydroxyvitamin D among micro and macrovascular complications of type 2 diabetes mellitus
Krishnamoorthy Ezhilarasi, Umapathy Dhamodharan, Viswanathan Vijay
International Journal of Biological Macromolecules.2018; 116: 346. CrossRef
Diabetic macular oedema: under‐represented in the genetic analysis of diabetic retinopathy
Suzanne Broadgate, Christine Kiire, Stephanie Halford, Victor Chong
Acta Ophthalmologica.2018; 96(A111): 1. CrossRef
Expression of JAZF1, ABCC8, KCNJ11and Notch2 genes and vitamin D receptor polymorphisms in type 2 diabetes, and their association with microvascular complications
Maha A. Rasheed, Nagwa Kantoush, Nagwa Abd El-Ghaffar, Hebatallah Farouk, Solaf Kamel, Alshaymaa Ahmed Ibrahim, Aliaa Shalaby, Eman Mahmoud, Hala M. Raslan, Omneya M. Saleh
Therapeutic Advances in Endocrinology and Metabolism.2017; 8(6): 97. CrossRef
Vitamin D and diabetes mellitus: Causal or casual association?
M. Grammatiki, E. Rapti, S. Karras, R. A. Ajjan, Kalliopi Kotsa
Reviews in Endocrine and Metabolic Disorders.2017; 18(2): 227. CrossRef
The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies
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Nutrients.2017; 9(3): 307. CrossRef
The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis
Yun Zhang, Wei Xia, Ping Lu, Huijuan Yuan
BioMed Research International.2016; 2016: 1. CrossRef
Candidate gene studies of diabetic retinopathy in human
Petra Priščáková, Gabriel Minárik, Vanda Repiská
Molecular Biology Reports.2016; 43(12): 1327. CrossRef

The Effects of Combined Treatment of Alendronate Plus Active or Plain Vitamin D on the Vitamin D Metabolism and Bone Turnover Markers in Patients with Osteoporosis.: Jee Hoon Koo, Hyun Kyung Kim, In Sung Kim, Eun Kyung Kim, Yoon Sok Chung; Endocrinol Metab. 2010;25(4):305-309. Published online December 1, 2010; DOI: https://doi.org/10.3803/EnM.2010.25.4.305

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Abstract PDF

BACKGROUND
The purpose of this study was to evaluate the effects of combined treatment with alendronate plus active or plain vitamin D on the vitamin D metabolism and bone turnover markers in patients with osteoporosis. METHODS: We investigated 297 osteoporosis outpatients who were treated with Maxmarvil(R) (alendronate 5 mg plus calcitriol 0.5 microg) daily or Fosamax Plus(R) (alendronate 70 mg plus cholecalciferol 2,800 IU) weekly for 1 year. The serum levels of 25(OH)D, parathyroid hormone (PTH), calcium, phosphorus, osteocalcin and N-telopeptide were measured at baseline and after 3, 6, and 12 months of treatment. RESULTS: The data of 72 of the 297 patients were analyzed. In the Maxmarvil(R) group (n = 45), the serum PTH significantly decreased by 17% from baseline at 6 months (microd = -6.10; +/- 0.85 SE; P < 0.05) and it remained suppressed to 12 months. The serum 25(OH)D tended to increase, but without significance. In the Fosamax Plus(R) group (n = 27), the serum 25(OH)D significantly increased by 77% from baseline at 3 months (microd = 9.87; +/- 2.32 SE; P < 0.05) and it remained significantly higher than baseline at 6 months (microd = 3.49; +/- 0.86 SE; P < 0.05) and 12 months (microd = 10.47; +/- 0.71 SE; P < 0.001). However, the serum PTH showed no significant decrease. In the Maxmarvil(R) group, the serum osteocalcin significantly decreased by 26% from baseline at 12 months (microd = -5.15; +/- 0.35 SE; P < 0.05), and in the Fosamax Plus(R) group, the serum osteocalcin significantly decreased by 19% from baseline at 6months (microd = -2.64; +/- 0.73 SE; P < 0.05) and it remained suppressed to 12 months (microd = -2.99; +/- 0.37 SE; P = 0.32) without significance. CONCLUSION: Maxmarvil(R) and Fosamax Plus(R) both improved the bone metabolism in Korean osteoporosis patients. Maxmarvil(R) significantly lowered the serum PTH levels, whereas Fosamax Plus(R) significantly elevated the serum 25(OH)D levels.

Citations

Citations to this article as recorded by

Efficacy and Safety of Weekly Alendronate Plus Vitamin D35600 IU versus Weekly Alendronate Alone in Korean Osteoporotic Women: 16-Week Randomized Trial
Kwang Joon Kim, Yong-Ki Min, Jung-Min Koh, Yoon-Sok Chung, Kyoung Min Kim, Dong-Won Byun, In Joo Kim, Mikyung Kim, Sung-Soo Kim, Kyung Wan Min, Ki Ok Han, Hyoung Moo Park, Chan Soo Shin, Sung Hee Choi, Jong Suk Park, Dong Jin Chung, Ji Oh Mok, Hong Sun Ba
Yonsei Medical Journal.2014; 55(3): 715. CrossRef

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