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• Bioactive Phytoconstituents Targeting Energy Expenditure and Appetite to Combat Obesity: A Comprehensive Review
  Gayatri Thapa, Pervej Alom Barbhuiya, Manash Pratim Pathak
  Current Nutrition Reports.2026;[Epub]     CrossRef
• Beyond Calories: Redox Interactions in Adipose Tissue That Lead to Metabolic Pathologies
  Alfredo Miranda-Martínez, Erika Rodríguez-Martínez, Pamela Barragán-Reséndiz, Selva Rivas-Arancibia
  Physiologia.2025; 5(4): 50.     CrossRef

Branched-chain amino acids (BCAAs) are essential amino acids that are not synthesized in our body; thus, they need to be obtained from food. They have shown to provide many physiological and metabolic benefits such as stimulation of pancreatic insulin secretion, milk production, adipogenesis, and enhanced immune function, among others, mainly mediated by mammalian target of rapamycin (mTOR) signaling pathway. After identified as a reliable marker of obesity and type 2 diabetes in recent years, an increasing number of studies have surfaced implicating BCAAs in the pathophysiology of other diseases such as cancers, cardiovascular diseases, and even neurodegenerative disorders like Alzheimer's disease. Here we discuss the most recent progress and review studies highlighting both correlational and potentially causative role of BCAAs in the development of these disorders. Although we are just beginning to understand the intricate relationships between BCAAs and some of the most prevalent chronic diseases, current findings raise a possibility that they are linked by a similar putative mechanism.

Citations

Citations to this article as recorded by  

• Characterizing the tuberculosis and type 2 diabetes mellitus comorbidity in a South African cohort using untargeted GCxGC-TOFMS metabolomics
  Karla Reinecke, Léanie Kleynhans, Katharina Ronacher, Du Toit Loots
  Metabolomics.2026;[Epub]     CrossRef
• Metabolic engineering of Pichia pastoris for high-efficiency production of branched-chain amino acids -enriched single-cell protein
  Cancan Dong, Kai Hong, Fan Wu, Yanfeng Wang, Youyan Rong, Xin Wu, Jian Zhang, Le Gao
  Bioresource Technology.2026; 444: 133988.     CrossRef
• Investigation of newborn blood metabolomics in varying intrauterine growth conditions
  Shengwen Wang, Xiaofei Lin, Yu Zhou, Xin Yang, Mingming Ou, Linxin Zhang, Yumei Wang, Jing Gao
  Jornal de Pediatria.2025; 101(1): 74.     CrossRef
• Apparent Saturation of Branched-Chain Amino Acid Catabolism After High Dietary Milk Protein Intake in Healthy Adults
  Emily Newton-Tanzer, Sultan Nilay Can, Hans Demmelmair, Jeannie Horak, Lesca Holdt, Berthold Koletzko, Veit Grote
  The Journal of Clinical Endocrinology & Metabolism.2025; 110(6): e1793.     CrossRef
• Transcutaneous auricular vagus nerve stimulation promotes adipose tissue browning and mitochondrial integrity by regulating BCAA metabolism in obese rats: an experimental study
  Chen Xin, Shaoyuan Li, Bowen Feng, Lan Sun, Yifei Wang, Jinling Zhang, Yuzhengheng Zhang, Ningyi Zou, Qing Zhou, Peijing Rong
  International Journal of Surgery.2025; 111(7): 4866.     CrossRef
• Integrating Metabolomics and Gut Microbiota to Identify Key Biomarkers and Regulatory Pathways Underlying Metabolic Heterogeneity in Childhood Obesity
  Zhiwei Xia, Yan Li, Jiyong Yin, Zhaolong Gong, Jing Sun, Shi Shen, Yi Yang, Tingting Liu, Liyuan Wang, Junsheng Huo
  Nutrients.2025; 17(11): 1876.     CrossRef
• Obesity Biomarkers: Exploring Factors, Ramification, Machine Learning, and AI‐Unveiling Insights in Health Research
  Ankita Awari, Deepika Kaushik, Ashwani Kumar, Emel Oz, Kenan Çadırcı, Charles Brennan, Charalampos Proestos, Mukul Kumar, Fatih Oz
  MedComm.2025;[Epub]     CrossRef
• BCAA metabolism in cancer progression and therapy resistance: The balance between fuel and cell signaling
  Yi Zhou, Jiahui Kou, Wenjin Li, Yuyao Wang, Xingxing Su, Hongguang Zhang
  Frontiers in Pharmacology.2025;[Epub]     CrossRef
• Gut microbiota alterations and their role in the pathophysiology of obesity following bariatric surgery
  Bas Voermans, Victor Gerdes, Max Nieuwdorp
  Expert Review of Endocrinology & Metabolism.2025; 20(4): 291.     CrossRef
• The potential of 1H NMR spectroscopy for diabetes diagnosis: a review of current applications and future directions
  Ariane Schiavenin, Letícia Bergoza, Ru Angelie Edrada-Ebel, Sidnei Moura
  Diabetes Research and Clinical Practice.2025; 226: 112380.     CrossRef
• Dietary Intake of Branched-Chain Amino Acids in Relation to Metabolic Health Status in Adolescents with Overweight and Obesity
  Pegah Hadi Sichani, Donya Poursalehi, Saeideh Mirzaei, Ali Asadi, Masoumeh Akhlaghi, Parvane Saneei
  Annals of Nutrition and Metabolism.2025; 81(4): 191.     CrossRef
• Plasma Amino Acid Levels in Obese Adolescents: A Case-Control Study and the Review of the Literature
  Pembe Soylu Üstkoyuncu, Durmuş Doğan, Fatih Kardaş, Mustafa Kendirci, Mehmet Akif Dündar, Arife Canpolat, Yasemin Altuner
  The Journal of Pediatric Academy.2025;[Epub]     CrossRef
• The impact of obesity and lipids on cancer: Insights into mechanisms and potential interventions
  Montserrat Romero, Yi-Fan Lian, Albert Piquer, Núria Borràs-Ferré, Antonio Zorzano, Saška Ivanova
  Seminars in Cancer Biology.2025; 115: 53.     CrossRef
• Unraveling Anabolic Resistance in Sarcopenia: A Narrative Synthesis of Age-Related Impairments in Muscle Protein Synthesis
  Hyun Joo Kang
  The Asian Journal of Kinesiology.2025; 27(3): 107.     CrossRef
• Role of branched chain amino acid metabolism on aging
  Zhaojia Wang, Shiran Yu, Xiao Du, Xuzhen Yan, Yanguo Xin
  Biogerontology.2025;[Epub]     CrossRef
• Branched-chain amino acids in bone health: From molecular mechanisms to therapeutic potential
  Zhen Liang, Zhanpeng Su, Haina Yang, Jinchang Zheng, Xinyuan Wu, Min Huang, Litao Duan, Shaoru Chen, Bo Wei, Xingxing Fan, Sien Lin
  Biomedicine & Pharmacotherapy.2025; 192: 118645.     CrossRef
• Artificial Intelligence and Multi-Omics Integration in Obesity: A Review of Computational Models for Predicting Metabolic Comorbidities
  Ankur Pan Saikia, Ananya Kalita
  Clinical & Translational Metabolism.2025;[Epub]     CrossRef
• Branched‐Chain Amino Acid Accumulation Fuels the Senescence‐Associated Secretory Phenotype
  Yaosi Liang, Christopher Pan, Tao Yin, Lu Wang, Xia Gao, Ergang Wang, Holly Quang, De Huang, Lianmei Tan, Kun Xiang, Yu Wang, Peter B. Alexander, Qi‐Jing Li, Tso‐Pang Yao, Zhao Zhang, Xiao‐Fan Wang
  Advanced Science.2024;[Epub]     CrossRef
• Exploring the functional roles of small-molecule metabolites in disease research: Recent advancements in metabolomics
  Aolei Tan, Xiaoxiao Ma
  Chinese Chemical Letters.2024; 35(8): 109276.     CrossRef
• Deficiency of BCAT2-mediated branched-chain amino acid catabolism promotes colorectal cancer development
  Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2024; 1870(2): 166941.     CrossRef
• Microbiome metabolite quantification methods enabling insights into human health and disease
  Jarrod Roach, Rohit Mital, Jacob J. Haffner, Nathan Colwell, Randy Coats, Horvey M. Palacios, Zongyuan Liu, Joseane L.P. Godinho, Monica Ness, Thilini Peramuna, Laura-Isobel McCall
  Methods.2024; 222: 81.     CrossRef
• Branched-chain amino acids promote occurrence and development of cardiovascular disease dependent on triglyceride metabolism via activation of the mTOR/SREBP-1/betatrophin pathway
  Jie Zhang, Ziyu Liu, Yaojun Ni, Yang Yu, Fei Guo, Yanwen Lu, Xiaoqing Wang, Hairong Hao, Shayan Li, Pan Wei, Weinan Yu, Wen Hu
  Molecular and Cellular Endocrinology.2024; 584: 112164.     CrossRef
• Heat stress reduces brown adipose tissue activity by exacerbating mitochondrial damage in type 2 diabetic mice
  Penghua Lai, Linlin Zhang, Yan Qiu, Jie Ren, Xue Sun, Ting Zhang, Liuyi Wang, Sijie Cheng, Sijia Liu, Hongli Zhuang, Daiwei Lu, Shaoliang Zhang, Huiqing Liang, Shaodong Chen
  Journal of Thermal Biology.2024; 119: 103799.     CrossRef
• Unraveling Adipose Tissue Dysfunction: Molecular Mechanisms, Novel Biomarkers, and Therapeutic Targets for Liver Fat Deposition
  Marta Lopez-Yus, Carlos Hörndler, Sofia Borlan, Vanesa Bernal-Monterde, Jose M. Arbones-Mainar
  Cells.2024; 13(5): 380.     CrossRef
• Microbial production of branched chain amino acids: Advances and perspectives
  Yanan Hao, Xuewei Pan, Jiajia You, Guomin Li, Meijuan Xu, Zhiming Rao
  Bioresource Technology.2024; 397: 130502.     CrossRef
• Maintenance of the branched-chain amino acid transporter LAT1 counteracts myotube atrophy following chemotherapy
  Stephen Mora, Olasunkanmi A. J. Adegoke
  American Journal of Physiology-Cell Physiology.2024; 326(3): C866.     CrossRef
• Metabolomics of Mice with Type 2 Diabetes and Nonalcoholic Fatty Liver Treated by Acupuncture
  Yihui Guo, Liying Zhang, Mengyuan Li, Linan Lin, Fuyu Xue, Wanning Gao, Xiaoru Xu, Haipeng Huang, Abdelilah Arredouani
  International Journal of Endocrinology.2024; 2024: 1.     CrossRef
• The effectiveness of low-calorie dietary interventions in managing obesity in patients. A review
  Ekaterina A. Troshina, Ksenia A. Komshilova, Natalia V. Silina, Ekaterina V. Ershova, Fatima K. Dzgoeva
  Consilium Medicum.2024; 26(4): 251.     CrossRef
• Duality of Branched-Chain Amino Acids in Chronic Cardiovascular Disease: Potential Biomarkers versus Active Pathophysiological Promoters
  Daniela Maria Tanase, Emilia Valasciuc, Claudia Florida Costea, Dragos Viorel Scripcariu, Anca Ouatu, Loredana Liliana Hurjui, Claudia Cristina Tarniceriu, Diana Elena Floria, Manuela Ciocoiu, Livia Genoveva Baroi, Mariana Floria
  Nutrients.2024; 16(12): 1972.     CrossRef
• Genetically predicted 1091 blood metabolites and 309 metabolite ratios in relation to risk of type 2 diabetes: a Mendelian randomization study
  Jixin Li, Wenru Wang, Fengzhao Liu, Linjie Qiu, Yan Ren, Meijie Li, Wenjie Li, Feng Gao, Jin Zhang
  Frontiers in Genetics.2024;[Epub]     CrossRef
• Serum Branched-Chain Amino Acids and Long-Term Complications of Liver Cirrhosis: Evidence from a Population-Based Prospective Study
  Yichen Zhu, Chengnan Guo, Hong Fan, Xinyu Han, Yi Li, Xingdong Chen, Tiejun Zhang
  Nutrients.2024; 16(14): 2295.     CrossRef
• Impact of Fava Bean (Vicia faba) Processing on Quality Characteristics and Digestibility of a Protein-Rich Snack
  Kateryna Khvostenko, Sara Muñoz-Pina, Jorge García-Hernández, Ana Heredia, Ana Andrés
  Foods.2024; 13(15): 2372.     CrossRef
• Bioactive profiling of two varieties of Indian legumes: adzuki and mung beans
  Ritu Sharma, Devendra Kumar, Rajinder K Gupta
  International Journal of Food Science and Technology.2024; 59(9): 6218.     CrossRef
• Branched-chain amino acids: physico-chemical properties, industrial synthesis and role in signaling, metabolism and energy production
  Philipp Reifenberg, Aline Zimmer
  Amino Acids.2024;[Epub]     CrossRef
• Cow’s Milk Bioactive Molecules in the Regulation of Glucose Homeostasis in Human and Animal Studies
  Emad Yuzbashian, Emily Berg, Stepheny C. de Campos Zani, Catherine B. Chan
  Foods.2024; 13(17): 2837.     CrossRef
• Growth-coupled production of L-isoleucine in Escherichia coli via metabolic engineering
  Nan Lu, Minhua Wei, Xuejing Yang, Yingzi Li, Hao Sun, Qianyu Yan, Haibin Zhang, Jilong He, Jie Ma, Menglei Xia, Chenglin Zhang
  Metabolic Engineering.2024; 86: 181.     CrossRef
• Branched-chain amino acid supplementation and voluntary running have distinct effects on the serum metabolome of rats with high or low intrinsic aerobic capacity
  Sira Karvinen, Tia-Marje K. Korhonen, Ronja Kiviö, Sanna Lensu, Bharat Gajera, Steven L. Britton, Lauren G. Koch, Anni I. Nieminen, Heikki Kainulainen
  Frontiers in Nutrition.2024;[Epub]     CrossRef
• Cecal metabolomics of 2 divergently selected rabbit lines revealed microbial mechanisms correlated to intramuscular fat deposition
  Agostina Zubiri-Gaitán, Marina Martínez-Álvaro, Agustín Blasco, Pilar Hernández
  Journal of Animal Science.2024;[Epub]     CrossRef
• Nutritional Difference in Infants: Contrasting Carbohydrate and Lipid Profiles between Normal and Obese States
  Ria Puspitasari, Nur Aisiyah Widjaja, Eva Ardianah, Tutfah Razzak Fitriari
  Media Gizi Kesmas.2024; 13(2): 763.     CrossRef
• Metabolic Signatures Elucidate the Effect of Body Mass Index on Type 2 Diabetes
  Qiuling Dong, Sidra Sidra, Christian Gieger, Rui Wang-Sattler, Wolfgang Rathmann, Cornelia Prehn, Jerzy Adamski, Wolfgang Koenig, Annette Peters, Harald Grallert, Sapna Sharma
  Metabolites.2023; 13(2): 227.     CrossRef
• The Preventive Effect of Exercise and Oral Branched-Chain Amino Acid Supplementation on Obesity-Induced Brain Changes in Ldlr−/−.Leiden Mice
  Klara J. Lohkamp, Anita M. van den Hoek, Gemma Solé-Guardia, Maria Lisovets, Talissa Alves Hoffmann, Konstantina Velanaki, Bram Geenen, Vivienne Verweij, Martine C. Morrison, Robert Kleemann, Maximilian Wiesmann, Amanda J. Kiliaan
  Nutrients.2023; 15(7): 1716.     CrossRef
• The Crosstalk between Gut Microbiota and White Adipose Tissue Mitochondria in Obesity
  Luca Colangeli, David Israel Escobar Marcillo, Valeria Simonelli, Egidio Iorio, Tommaso Rinaldi, Paolo Sbraccia, Paola Fortini, Valeria Guglielmi
  Nutrients.2023; 15(7): 1723.     CrossRef
• Prebiotic and Probiotic Modulation of the Microbiota–Gut–Brain Axis in Depression
  Daniel E. Radford-Smith, Daniel C. Anthony
  Nutrients.2023; 15(8): 1880.     CrossRef
• Machine learning model to predict obesity using gut metabolite and brain microstructure data
  Vadim Osadchiy, Roshan Bal, Emeran A. Mayer, Rama Kunapuli, Tien Dong, Priten Vora, Danny Petrasek, Cathy Liu, Jean Stains, Arpana Gupta
  Scientific Reports.2023;[Epub]     CrossRef
• Insulin Resistance and Impaired Branched-Chain Amino Acid Metabolism in Alzheimer’s Disease
  Rui Liu, Lei Zhang, Hao You
  Journal of Alzheimer's Disease.2023; 93(3): 847.     CrossRef
• Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments
  Rexiati Ruze, Tiantong Liu, Xi Zou, Jianlu Song, Yuan Chen, Ruiyuan Xu, Xinpeng Yin, Qiang Xu
  Frontiers in Endocrinology.2023;[Epub]     CrossRef
• Crosstalk between arginine, glutamine, and the branched chain amino acid metabolism in the tumor microenvironment
  Tanner J. Wetzel, Sheila C. Erfan, Lucas D. Figueroa, Leighton M. Wheeler, Elitsa A. Ananieva
  Frontiers in Oncology.2023;[Epub]     CrossRef
• Stachydrine, N‐acetylornithine and trimethylamine N‐oxide levels as candidate milk biomarkers of maternal consumption of an obesogenic diet during lactation
  Pedro Castillo, Ondrej Kuda, Jan Kopecky, Catalina Amadora Pomar, Andreu Palou, Mariona Palou, Catalina Picó
  BioFactors.2023; 49(5): 1022.     CrossRef
• Biofunctionalization of natural extracts, trends in biological activity and kinetic release
  Abraham Osiris Martínez-Olivo, Víctor Manuel Zamora-Gasga, Luis Medina-Torres, Alejandro Pérez-Larios, Sonia Guadalupe Sáyago-Ayerdi, Jorge Alberto Sánchez-Burgos
  Advances in Colloid and Interface Science.2023; 318: 102938.     CrossRef
• Muscle Traits, Sarcopenia, and Sarcopenic Obesity: A Vitamin D Mendelian Randomization Study
  Joshua P. Sutherland, Ang Zhou, Elina Hyppönen
  Nutrients.2023; 15(12): 2703.     CrossRef
• Bioactive Ingredients in Traditional Fermented Food Condiments: Emerging Products for Prevention and Treatment of Obesity and Type 2 Diabetes
  Alphonse Laya, Honoré Wangso, Iva Fernandes, Raphaël Djakba, Joana Oliveira, Eugenia Carvalho, Wen yi Kang
  Journal of Food Quality.2023; 2023: 1.     CrossRef
• Sex related differences in muscle health and metabolism in chronic obstructive pulmonary disease
  Mariëlle P.K.J. Engelen, Sarah K. Kirschner, Kimberly S. Coyle, David Argyelan, Gabriel Neal, Srinivasan Dasarathy, Nicolaas E.P. Deutz
  Clinical Nutrition.2023; 42(9): 1737.     CrossRef
• Depiction of Branched-Chain Amino Acids (BCAAs) in Diabetes with a Focus on Diabetic Microvascular Complications
  Daniela Maria Tanase, Evelina Maria Gosav, Tina Botoc, Mariana Floria, Claudia Cristina Tarniceriu, Minela Aida Maranduca, Anca Haisan, Andrei Ionut Cucu, Ciprian Rezus, Claudia Florida Costea
  Journal of Clinical Medicine.2023; 12(18): 6053.     CrossRef
• Genetic and Lifestyle-Related Factors Influencing Serum Hyper-Propionylcarnitine Concentrations and Their Association with Metabolic Syndrome and Cardiovascular Disease Risk
  Yong-Hwa Lee, Sunmin Park
  International Journal of Molecular Sciences.2023; 24(21): 15810.     CrossRef
• Relationship between Components, Intestinal Microbiota, and Mechanism of Hypoglycemic Effect of the Saggy Ink Cap Medicinal Mushroom (Coprinus Comatus, Agaricomycetes): A Review
  Wei Wang, Min Sun, Jinyan Yu, Xumin Ma, Chunchao Han
  International Journal of Medicinal Mushrooms.2023; 25(12): 81.     CrossRef
• High-protein diet with excess leucine prevents inactivity-induced insulin resistance in women
  Alessandro Mangogna, Filippo Giorgio Di Girolamo, Nicola Fiotti, Pierandrea Vinci, Matteo Landolfo, Filippo Mearelli, Gianni Biolo
  Clinical Nutrition.2023; 42(12): 2578.     CrossRef
• Toward Systems-Level Metabolic Analysis in Endocrine Disorders and Cancer
  Aliya Lakhani, Da Hyun Kang, Yea Eun Kang, Junyoung O. Park
  Endocrinology and Metabolism.2023; 38(6): 619.     CrossRef
• Dietary intake of branched-chain amino acids in relation to general and abdominal obesity
  Farzaneh Asoudeh, Asma Salari-Moghaddam, Ammar Hassanzadeh Keshteli, Ahmad Esmaillzadeh, Peyman Adibi
  Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2022; 27(4): 1303.     CrossRef
• Tea polyphenol – gut microbiota interactions: hints on improving the metabolic syndrome in a multi-element and multi-target manner
  Hui Ma, Yaozhong Hu, Bowei Zhang, Zeping Shao, Eugeni Roura, Shuo Wang
  Food Science and Human Wellness.2022; 11(1): 11.     CrossRef
• First trimester metabolomics 1H-NMR study of the urinary profile predicts gestational diabetes mellitus development in obese women
  Cristina Piras, Isabella Neri, Roberta Pintus, Antonio Noto, Elisabetta Petrella, Francesca Monari, Angelica Dessì, Vassilios Fanos, Luigi Atzori, Fabio Facchinetti
  The Journal of Maternal-Fetal & Neonatal Medicine.2022; 35(25): 8275.     CrossRef
• Exogenous isoleucine can confer browning resistance on fresh-cut potato by suppressing polyphenol oxidase activity and improving the antioxidant capacity
  Zan Meng, Tong Wang, Aman Ullah Malik, Qingguo Wang
  Postharvest Biology and Technology.2022; 184: 111772.     CrossRef
• Impact of thermal treatment and fermentation by lactic acid bacteria on sorghum metabolite changes, their antioxidant and antidiabetic activities
  Fred Kwame Ofosu, Fazle Elahi, Eric Banan-Mwine Daliri, Sang-Ik Han, Deog-Hwan Oh
  Food Bioscience.2022; 45: 101502.     CrossRef
• Infant intakes of human milk branched chain amino acids are negatively associated with infant growth and influenced by maternal body mass index
  Jessica L. Saben, Clark R. Sims, Lindsay Pack, Renny Lan, Elisabet Børsheim, Aline Andres
  Pediatric Obesity.2022;[Epub]     CrossRef
• Roux-En-Y Gastric Bypass (RYGB) Surgery during High Liquid Sucrose Diet Leads to Gut Microbiota-Related Systematic Alterations
  Laimdota Zizmare, Christina N. Boyle, Sabrina Buss, Sandrine Louis, Laura Kuebler, Ketki Mulay, Ralf Krüger, Lara Steinhauer, Isabelle Mack, Manuel Rodriguez Gomez, Kristina Herfert, Yvonne Ritze, Christoph Trautwein
  International Journal of Molecular Sciences.2022; 23(3): 1126.     CrossRef
• Omics Analyses of Intestinal Microbiota and Hypothalamus Clock Genes in Circadian Disturbance Model Mice Fed with Green Tea Polyphenols
  Yuting Zhang, Lu Cheng, Yanan Liu, Ruilin Zhang, Zufang Wu, Kejun Cheng, Xin Zhang
  Journal of Agricultural and Food Chemistry.2022; 70(6): 1890.     CrossRef
• Age, Sex, Body Mass Index, Diet and Menopause Related Metabolites in a Large Homogeneous Alpine Cohort
  Vinicius Verri Hernandes, Nikola Dordevic, Essi Marjatta Hantikainen, Baldur Bragi Sigurdsson, Sigurður Vidir Smárason, Vanessa Garcia-Larsen, Martin Gögele, Giulia Caprioli, Ilaria Bozzolan, Peter P. Pramstaller, Johannes Rainer
  Metabolites.2022; 12(3): 205.     CrossRef
• α-ketoisocaproic acid promotes ER stress through impairment of autophagy, thereby provoking lipid accumulation and insulin resistance in murine preadipocytes
  Tae Jun Park, Seung Yeon Park, Hyun Jung Lee, A.M. Abd El-Aty, Ji Hoon Jeong, Tae Woo Jung
  Biochemical and Biophysical Research Communications.2022; 603: 109.     CrossRef
• The associations of serum valine with mild cognitive impairment and Alzheimer’s disease
  Yong-lan Xiong, Joseph Therriault, Shu-jiang Ren, Xiao-jun Jing, Hua Zhang
  Aging Clinical and Experimental Research.2022; 34(8): 1807.     CrossRef
• The Critical Role of the Branched Chain Amino Acids (BCAAs) Catabolism-Regulating Enzymes, Branched-Chain Aminotransferase (BCAT) and Branched-Chain α-Keto Acid Dehydrogenase (BCKD), in Human Pathophysiology
  Aikaterini Dimou, Vasilis Tsimihodimos, Eleni Bairaktari
  International Journal of Molecular Sciences.2022; 23(7): 4022.     CrossRef
• Obesity, exercise training, and BCAA supplementation: All that glitters (may not be) gold
  Stephen J. Carter, Emily B. Long, Cydne A. Perry
  Obesity.2022; 30(6): 1139.     CrossRef
• Effects of serum branched-chain amino acids on nonalcoholic fatty liver disease and subsequent cardiovascular disease
  Fei Guo, Rui Chen, Linghui Kong, Pan Wei, Ziyu Liu, Xiaoqing Wang, Hairong Hao, Yanwen Lu, Wen Hu
  Hepatology International.2022; 16(6): 1424.     CrossRef
• Advances in multi-omics study of biomarkers of glycolipid metabolism disorder
  Xinyi Fang, Runyu Miao, Jiahua Wei, Haoran Wu, Jiaxing Tian
  Computational and Structural Biotechnology Journal.2022; 20: 5935.     CrossRef
• Targeted Metabolomics Revealed a Sex-Dependent Signature for Metabolic Syndrome in the Mexican Population
  Berenice Palacios-González, Guadalupe León-Reyes, Berenice Rivera-Paredez, Isabel Ibarra-González, Marcela Vela-Amieva, Yvonne N. Flores, Samuel Canizales-Quinteros, Jorge Salmerón, Rafael Velázquez-Cruz
  Nutrients.2022; 14(18): 3678.     CrossRef
• Case report: NAFLD and maple syrup urine disease: Is there an interplay between branched-chain amino acids and fructose consumption?
  Helena Moreira-Silva, Sandra Ferreira, Manuela Almeida, Isabel Gonçalves, Maria Augusta Cipriano, J. R. Vizcaíno, Ermelinda Santos-Silva, Esmeralda Gomes-Martins
  Frontiers in Pediatrics.2022;[Epub]     CrossRef
• A self-assembled leucine polymer sensitizes leukemic stem cells to chemotherapy by inhibiting autophagy in acute myeloid leukemia
  Xi Xu, Jian Wang, Tong Tong, Wenwen Zhang, Jin Wang, Weiwei Ma, Shunqing Wang, Dunhua Zhou, Jun Wu, Linjia Jiang, Meng Zhao
  Haematologica.2022; 107(10): 2344.     CrossRef
• Effect of dietary protein content shift on aging in elderly rats by comprehensive quantitative score and metabolomics analysis
  Wenxuan Zheng, Ruiding Li, Yang Zhou, Fengcui Shi, Yao Song, Yanting Liao, Fan Zhou, Xiaohua Zheng, Jingwen Lv, Quanyang Li
  Frontiers in Nutrition.2022;[Epub]     CrossRef
• Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men
  M. H. Sayda, M. H. Abdul Aziz, N. Gharahdaghi, D. J. Wilkinson, P. L. Greenhaff, B. E. Phillips, K. Smith, I. Idris, P. J. Atherton
  Scientific Reports.2022;[Epub]     CrossRef
• Dietary Protein and Amino Acid Deficiency Inhibit Pancreatic Digestive Enzyme mRNA Translation by Multiple Mechanisms
  Maria Dolors Sans, Stephen J. Crozier, Nancy L. Vogel, Louis G. D’Alecy, John A. Williams
  Cellular and Molecular Gastroenterology and Hepatology.2021; 11(1): 99.     CrossRef
• Isoleucine increases muscle mass through promoting myogenesis and intramyocellular fat deposition
  Shuge Liu, Yunmei Sun, Rui Zhao, Yingqian Wang, Wanrong Zhang, Weijun Pang
  Food & Function.2021; 12(1): 144.     CrossRef
• Serum metabolomics study of women with different annual decline rates of anti-Müllerian hormone: an untargeted gas chromatography–mass spectrometry-based study
  Nazanin Moslehi, Parvin Mirmiran, Rezvan Marzbani, Hassan Rezadoost, Mehdi Mirzaie, Fereidoun Azizi, Fahimeh Ramezani Tehrani
  Human Reproduction.2021; 36(3): 721.     CrossRef
• Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID‐19
  Aradhana Mariam Philips, Nooruddin Khan
  Obesity Reviews.2021;[Epub]     CrossRef
• The chemical mechanisms of the enzymes in the branched-chain amino acids biosynthetic pathway and their applications
  Yan-Fei Liang, Zi-Xian Long, Ya-Jian Zhang, Cai-Yun Luo, Le-Tian Yan, Wen-Yun Gao, Heng Li
  Biochimie.2021; 184: 72.     CrossRef
• Plasma Metabolomic Profiling in 1391 Subjects with Overweight and Obesity from the SPHERE Study
  Gianfranco Frigerio, Chiara Favero, Diego Savino, Rosa Mercadante, Benedetta Albetti, Laura Dioni, Luisella Vigna, Valentina Bollati, Angela Cecilia Pesatori, Silvia Fustinoni
  Metabolites.2021; 11(4): 194.     CrossRef
• Sarcopenic Obesity and Amino Acids: Concord Health and Ageing in Men Project
  David G Le Couteur, David J Handelsman, Fiona Stanaway, Louise M Waite, Fiona M Blyth, Vasi Naganathan, Robert G Cumming, Vasant Hirani, Rafael de Cabo
  The Journals of Gerontology: Series A.2021; 76(6): 1000.     CrossRef
• Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition
  Nathalie Kliemann, Vivian Viallon, Neil Murphy, Rebecca J. Beeken, Joseph A. Rothwell, Sabina Rinaldi, Nada Assi, Eline H. van Roekel, Julie A. Schmidt, Kristin Benjaminsen Borch, Claudia Agnoli, Ann H. Rosendahl, Hanna Sartor, José María Huerta, Anne Tjø
  BMC Medicine.2021;[Epub]     CrossRef
• Plasma Amino Acids and Residual Hypertriglyceridemia in Diabetic Patients Under Statins: Two Independent Cross-Sectional Hospital-Based Cohorts
  Shuang Wang, Yun-Feng Cao, Xiao-Yu Sun, Mo Hong, Zhong-Ze Fang, Hui-Huan Luo, Huan Sun, Ping Yang
  Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
• Identification of Metabolic Phenotypes in Young Adults with Obesity by 1H NMR Metabolomics of Blood Serum
  Khin Thandar Htun, Jie Pan, Duanghathai Pasanta, Montree Tungjai, Chatchanok Udomtanakunchai, Sirirat Chancharunee, Siriprapa Kaewjaeng, Hong Joo Kim, Jakrapong Kaewkhao, Suchart Kothan
  Life.2021; 11(6): 574.     CrossRef
• A Metabolic Pattern in Healthy Subjects Given a Single Dose of Metformin: A Metabolomics Approach
  Lina A. Dahabiyeh, Muhammad Mujammami, Tawfiq Arafat, Hicham Benabdelkamel, Assim A. Alfadda, Anas M. Abdel Rahman
  Frontiers in Pharmacology.2021;[Epub]     CrossRef
• Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism
  Gagandeep Mann, Stephen Mora, Glory Madu, Olasunkanmi A. J. Adegoke
  Frontiers in Physiology.2021;[Epub]     CrossRef
• Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes
  David Z. Pan, Zong Miao, Caroline Comenho, Sandhya Rajkumar, Amogha Koka, Seung Hyuk T. Lee, Marcus Alvarez, Dorota Kaminska, Arthur Ko, Janet S. Sinsheimer, Karen L. Mohlke, Nicholas Mancuso, Linda Liliana Muñoz-Hernandez, Miguel Herrera-Hernandez, Maria
  Genome Medicine.2021;[Epub]     CrossRef
• Antidiabetic Effect of Noodles Containing Fermented Lettuce Extracts
  Soon Yeon Jeong, Eunjin Kim, Ming Zhang, Yun-Seong Lee, Byeongjun Ji, Sun-Hee Lee, Yu Eun Cheong, Soon-Il Yun, Young-Soo Kim, Kyoung Heon Kim, Min Sun Kim, Hyun Soo Chun, Sooah Kim
  Metabolites.2021; 11(8): 520.     CrossRef
• Targeted and Untargeted Mass Spectrometry Reveals the Impact of High-Fat Diet on Peripheral Amino Acid Regulation in a Mouse Model of Alzheimer’s Disease
  Amelia L. Taylor, Don E. Davis, Simona G. Codreanu, Fiona E. Harrison, Stacy D. Sherrod, John A. McLean
  Journal of Proteome Research.2021; 20(9): 4405.     CrossRef
• The Association of 9 Amino Acids With Cardiovascular Events in Finnish Men in a 12-Year Follow-up Study
  Raimo Jauhiainen, Jagadish Vangipurapu, Annamaria Laakso, Teemu Kuulasmaa, Johanna Kuusisto, Markku Laakso
  The Journal of Clinical Endocrinology & Metabolism.2021; 106(12): 3448.     CrossRef
• Serum Metabolite Profile Associated with Sex-Dependent Visceral Adiposity Index and Low Bone Mineral Density in a Mexican Population
  Berenice Palacios-González, Guadalupe León-Reyes, Berenice Rivera-Paredez, Isabel Ibarra-González, Marcela Vela-Amieva, Yvonne N. Flores, Samuel Canizales-Quinteros, Jorge Salmerón, Rafael Velázquez-Cruz
  Metabolites.2021; 11(9): 604.     CrossRef
• Branched chain amino acids—friend or foe in the control of energy substrate turnover and insulin sensitivity?
  Elżbieta Supruniuk, Ewa Żebrowska, Adrian Chabowski
  Critical Reviews in Food Science and Nutrition.2021; : 1.     CrossRef
• Diet Effects on Cerebrospinal Fluid Amino Acids Levels in Adults with Normal Cognition and Mild Cognitive Impairment
  Kate J. Russin, K. Sreekumaran Nair, Thomas J. Montine, Laura D. Baker, Suzanne Craft
  Journal of Alzheimer's Disease.2021; 84(2): 843.     CrossRef
• QSHY Granules Promote White Adipose Tissue Browning and Correct BCAAs Metabolic Disorder in NAFLD Mice
  Binbin Zhang, Mingzhu Ni, Xiaojing Li, Qiaohong Liu, Yiyang Hu, Yu Zhao
  Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 4241.     CrossRef
• The Changes in Endogenous Metabolites in Hyperlipidemic Rats Treated with Herbal Mixture Containing Lemon, Apple Cider, Garlic, Ginger, and Honey
  Azliana Abu Bakar Sajak, Azrina Azlan, Faridah Abas, Hazilawati Hamzah
  Nutrients.2021; 13(10): 3573.     CrossRef
• Integration of Transcriptome and Metabolome Provides Unique Insights to Pathways Associated With Obese Breast Cancer Patients
  Mohammed A. Hassan, Kaltoom Al-Sakkaf, Mohammed Razeeth Shait Mohammed, Ashraf Dallol, Jaudah Al-Maghrabi, Alia Aldahlawi, Sawsan Ashoor, Mabrouka Maamra, Jiannis Ragoussis, Wei Wu, Mohammad Imran Khan, Abdulrahman L. Al-Malki, Hani Choudhry
  Frontiers in Oncology.2020;[Epub]     CrossRef
• Omics Biomarkers in Obesity: Novel Etiological Insights and Targets for Precision Prevention
  Krasimira Aleksandrova, Caue Egea Rodrigues, Anna Floegel, Wolfgang Ahrens
  Current Obesity Reports.2020; 9(3): 219.     CrossRef
• Why Are Branched-Chain Amino Acids Increased in Starvation and Diabetes?
  Milan Holeček
  Nutrients.2020; 12(10): 3087.     CrossRef
• Differential gene signature in adipose tissue depots of growth hormone transgenic mice
  Silvana Duran‐Ortiz, Jonathan A. Young, Adam Jara, Elizabeth A. Jensen, Reetobrata Basu, Edward O. List, Yanrong Qian, John J. Kopchick, Darlene E. Berryman
  Journal of Neuroendocrinology.2020;[Epub]     CrossRef
• Prognostic Role of Serum Amino Acids in Head and Neck Cancer
  Gabriella Cadoni, Luca Giraldi, Carlo Chiarla, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Stefano Settimi, Jacopo Galli, Gaetano Paludetti, Dario Arzani, Stefania Boccia, Ivo Giovannini, Giovanni Almadori, Leigh A. Madden
  Disease Markers.2020; 2020: 1.     CrossRef
• Lipid changes in the metabolome of a single case study with maple syrup urine disease (MSUD) after five days of improved diet adherence of controlled branched-chain amino acids (BCAA)
  Teresa D. Douglas, L. Kristin Newby, Julie Eckstrand, Douglas Wixted, Rani H. Singh
  Molecular Genetics and Metabolism Reports.2020; 25: 100651.     CrossRef
• Branched chain amino acids, aging and age-related health
  David G. Le Couteur, Samantha M. Solon-Biet, Victoria C. Cogger, Rosilene Ribeiro, Rafael de Cabo, David Raubenheimer, Gregory J. Cooney, Stephen J. Simpson
  Ageing Research Reviews.2020; 64: 101198.     CrossRef
• Branched-chain ketoacid overload inhibits insulin action in the muscle
  Dipsikha Biswas, Khoi T. Dao, Angella Mercer, Andrew M. Cowie, Luke Duffley, Yassine El Hiani, Petra C. Kienesberger, Thomas Pulinilkunnil
  Journal of Biological Chemistry.2020; 295(46): 15597.     CrossRef