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Volume 32(4); December 2017
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Review Articles
Active Surveillance of Papillary Thyroid Microcarcinoma: A Mini-Review from Korea
Tae Yong Kim, Young Kee Shong
Endocrinol Metab. 2017;32(4):399-406.   Published online December 14, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.399
  • 5,139 View
  • 66 Download
  • 32 Web of Science
  • 33 Crossref
AbstractAbstract PDFPubReader   

In Korea, the incidence of thyroid cancer increased explosively in the early 2000s, and reached a plateau in the early 2010s. Most cases of newly diagnosed thyroid cancer are small indolent microcarcinoma and could be good candidates for active surveillance (AS) instead of immediate surgery. Many considerations must be taken into account for establishing selection criteria for candidates for AS of papillary thyroid microcarcinoma (PTMC), including the characteristics of the tumor, the patient, and the medical team. If possible, AS of PTMC should be a part of a prospective clinical trial to ensure long-term safety and to identify clinical and/or molecular markers of the progression of PTMC. In this review, we discuss lessons regarding surgical interventions for PTMC, and then describe the concept, application, caveats, unanswered questions, and future perspectives of AS of PTMC. For appropriately selected patients with PTMC, AS can be a good alternative to immediate surgery.

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  • Unnecessary thyroid nodule biopsy rates under four ultrasound risk stratification systems: a systematic review and meta-analysis
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  • Tumor Volume Doubling Time in Active Surveillance of Papillary Thyroid Microcarcinoma: A Multicenter Cohort Study in Korea
    Meihua Jin, Hye In Kim, Jeonghoon Ha, Min Ji Jeon, Won Gu Kim, Dong-Jun Lim, Tae Yong Kim, Jae Hoon Chung, Young Kee Shong, Tae Hyuk Kim, Won Bae Kim
    Thyroid.2021; 31(10): 1494.     CrossRef
  • Long-Term Efficacy of Ultrasound-Guided Laser Ablation for Papillary Thyroid Microcarcinoma: Results of a 10-Year Retrospective Study
    Ho Jin Kim, Seung Min Chung, Hanbyul Kim, Ju Young Jang, Jae Hong Yang, Jun Sung Moon, Gitak Son, Jong-Ryool Oh, Jong Yup Bae, Hyundae Yoon
    Thyroid.2021; 31(11): 1723.     CrossRef
  • Cost-Effectiveness Analysis of Active Surveillance Compared to Early Surgery in Small Papillary Thyroid Cancer: A Systemic Review
    Han-sang Baek, Chai-ho Jeong, Jeonghoon Ha, Ja-Seong Bae, Jeong-soo Kim, Dong-Jun Lim, Chul-Min Kim
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    International Journal of Thyroidology.2021; 14(2): 87.     CrossRef
  • Deep Learning based Classification of Thyroid Cancer using Different Medical Imaging Modalities : A Systematic Review
    Maheen Ilyas, Hassaan Malik, Muhammad Adnan, Umair Bashir, Wajahat Anwaar Bukhari, Muhammad Imran Ali Khan, Adnan Ahmad
    VFAST Transactions on Software Engineering.2021; 9(4): 1.     CrossRef
  • Does the ATA Risk Stratification Apply to Patients with Papillary Thyroid Microcarcinoma?
    Dessislava I. Stefanova, Arpita Bose, Timothy M. Ullmann, Jessica N. Limberg, Brendan M. Finnerty, Rasa Zarnegar, Thomas J. Fahey, Toni Beninato
    World Journal of Surgery.2020; 44(2): 452.     CrossRef
  • Clinical Outcomes after Early and Delayed Radioiodine Remnant Ablation in Patients with Low-Risk Papillary Thyroid Carcinoma: Propensity Score Matching Analysis
    Jonghwa Ahn, Meihua Jin, Eyun Song, Min Ji Jeon, Tae Yong Kim, Jin-Sook Ryu, Won Bae Kim, Young Kee Shong, Ji Min Han, Won Gu Kim
    Endocrinology and Metabolism.2020; 35(4): 830.     CrossRef
  • Impact of the new guidelines of the American Thyroid Association on the treatment of the differentiated thyroid tumor in an Italian center with medium-high volume thyroid surgery
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    BMC Surgery.2019;[Epub]     CrossRef
  • Malignancy risk of initially benign thyroid nodules: validation with various Thyroid Imaging Reporting and Data System guidelines
    Su Min Ha, Jung Hwan Baek, Young Jun Choi, Sae Rom Chung, Tae Yon Sung, Tae Yong Kim, Jeong Hyun Lee
    European Radiology.2019; 29(1): 133.     CrossRef
  • Proteomic analysis of the papillary thyroid microcarcinoma
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  • Quality of Life in Patients with Papillary Thyroid Microcarcinoma Managed by Active Surveillance or Lobectomy: A Cross-Sectional Study
    Min Ji Jeon, Yu-Mi Lee, Tae-Yon Sung, Minkyu Han, Yong-Wook Shin, Won Gu Kim, Tae Yong Kim, Ki-Wook Chung, Young Kee Shong, Won Bae Kim
    Thyroid.2019; 29(7): 956.     CrossRef
  • Papillary Thyroid Micro Carcinoma: The Incidence of High-Risk Features and Its Prognostic Implications
    Rui Gao, Xi Jia, Yiqian Liang, Kun Fan, Xiaoxiao Wang, Yuanbo Wang, Lulu Yang, Aimin Yang, Guangjian Zhang
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Tumor Volume Doubling Time in Active Surveillance of Papillary Thyroid Carcinoma
    Hye-Seon Oh, Hyemi Kwon, Eyun Song, Min Ji Jeon, Tae Yong Kim, Jeong Hyun Lee, Won Bae Kim, Young Kee Shong, Ki-Wook Chung, Jung Hwan Baek, Won Gu Kim
    Thyroid.2019; 29(5): 642.     CrossRef
  • Deciphering novel biomarkers of lymph node metastasis of thyroid papillary microcarcinoma using proteomic analysis of ultrasound-guided fine-needle aspiration biopsy samples
    Peng Lin, Zhina Yao, Yu Sun, Wenjuan Li, Yan Liu, Kai Liang, Yuan Liu, Jun Qin, Xinguo Hou, Li Chen
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  • Diagnostic performance of CT in detection of metastatic cervical lymph nodes in patients with thyroid cancer: a systematic review and meta-analysis
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  • Diagnostic Performance of Practice Guidelines for Thyroid Nodules: Thyroid Nodule Size versus Biopsy Rates
    Su Min Ha, Jung Hwan Baek, Dong Gyu Na, Chong Hyun Suh, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee
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    Syed Ali Imran, Karen Chu, Murali Rajaraman, Drew Rajaraman, Sunita Ghosh, Sarah De Brabandere, Stephanie M. Kaiser, Stan Van Uum
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  • Active Surveillance of Papillary Thyroid Microcarcinoma: A Mini-Review from Korea (Endocrinol Metab2017;32:399-406, Tae Yong Kim et al.)
    Hui Sun, Gianlorenzo Dionigi
    Endocrinology and Metabolism.2018; 33(1): 135.     CrossRef
  • Active Surveillance of Low-Risk Papillary Thyroid Microcarcinoma: A Multi-Center Cohort Study in Korea
    Hye-Seon Oh, Jeonghoon Ha, Hye In Kim, Tae Hyuk Kim, Won Gu Kim, Dong-Jun Lim, Tae Yong Kim, Sun Wook Kim, Won Bae Kim, Young Kee Shong, Jae Hoon Chung, Jung Hwan Baek
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Close layer
Recent Advances in Core Needle Biopsy for Thyroid Nodules
Chan Kwon Jung, Jung Hwan Baek
Endocrinol Metab. 2017;32(4):407-412.   Published online December 14, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.407
  • 6,017 View
  • 86 Download
  • 28 Web of Science
  • 26 Crossref
AbstractAbstract PDFPubReader   

Core needle biopsy (CNB) was introduced as an alternative diagnostic tool to fine-needle aspiration (FNA), and is increasingly being used in the preoperative assessment of thyroid nodules. CNB provides a definitive diagnosis in most cases, but it sometimes may be inconclusive. CNB has the advantage of enabling a histologic examination in relation to the surrounding thyroid tissue, immunohistochemistry, and molecular testing that can provide a more accurate assessment than FNA in selected cases. Nevertheless, CNB should be performed only by experienced experts in thyroid interventions to prevent complications because CNB needles are larger in caliber than FNA needles. As recent evidence has accumulated, and with improvements in the technique and devices for thyroid CNB, the Korean Society of Thyroid Radiology released its 2016 thyroid CNB guidelines and the Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group published a consensus statement on the pathology reporting system for thyroid CNB in 2015. This review presents the current consensus and recommendations regarding thyroid CNB, focusing on indications, complications, and pathologic classification and reporting.

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    European Radiology.2019; 29(1): 133.     CrossRef
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    Hye-Seon Oh, Hyemi Kwon, Eyun Song, Min Ji Jeon, Tae Yong Kim, Jeong Hyun Lee, Won Bae Kim, Young Kee Shong, Ki-Wook Chung, Jung Hwan Baek, Won Gu Kim
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Close layer
Alternative Polyadenylation in Human Diseases
Jae-Woong Chang, Hsin-Sung Yeh, Jeongsik Yong
Endocrinol Metab. 2017;32(4):413-421.   Published online December 14, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.413
  • 5,928 View
  • 95 Download
  • 28 Web of Science
  • 27 Crossref
AbstractAbstract PDFPubReader   

Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing. It is prevalent through all eukaryotes and has emerged as a key mechanism for controlling gene expression. Alternative polyadenylation (APA) plays an important role for cell growth, proliferation, and differentiation. In this review, we discuss the functions of APA related with various physiological conditions including cellular metabolism, mRNA processing, and protein diversity in a variety of disease models. We also discuss the molecular mechanisms underlying APA regulation, such as variations in the concentration of mRNA processing factors and RNA-binding proteins, as well as global transcriptome changes under cellular signaling pathway.

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Close layer
Editorial
Decreasing Lean Body Mass with Age: Challenges and Opportunities for Novel Therapies
Chrysoula Boutari, Christos S. Mantzoros
Endocrinol Metab. 2017;32(4):422-425.   Published online December 14, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.422
  • 5,172 View
  • 39 Download
  • 16 Web of Science
  • 19 Crossref
PDFPubReader   

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Close layer
Original Articles
Clinical Study
Factors Associated with Postoperative Diabetes Insipidus after Pituitary Surgery
Antonio L. Faltado, Anna Angelica Macalalad-Josue, Ralph Jason S. Li, John Paul M. Quisumbing, Marc Gregory Y. Yu, Cecilia A. Jimeno
Endocrinol Metab. 2017;32(4):426-433.   Published online November 21, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.426
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  • 13 Web of Science
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AbstractAbstract PDFPubReader   
Background

Determining risk factors for diabetes insipidus (DI) after pituitary surgery is important in improving patient care. Our objective is to determine the factors associated with DI after pituitary surgery.

Methods

We reviewed records of patients who underwent pituitary surgery from 2011 to 2015 at Philippine General Hospital. Patients with preoperative DI were excluded. Multiple logistic regression analysis was performed and a predictive model was generated. The discrimination abilities of the predictive model and individual variables were assessed using the receiving operator characteristic curve.

Results

A total of 230 patients were included. The rate of postoperative DI was 27.8%. Percent change in serum Na (odds ratio [OR], 1.39; 95% confidence interval [CI], 1.15 to 1.69); preoperative serum Na (OR, 1.19; 95% CI, 1.02 to 1.40); and performance of craniotomy (OR, 5.48; 95% CI, 1.60 to 18.80) remained significantly associated with an increased incidence of postoperative DI, while percent change in urine specific gravity (USG) (OR, 0.53; 95% CI, 0.33 to 0.87) and meningioma on histopathology (OR, 0.05; 95% CI, 0.04 to 0.70) were significantly associated with a decreased incidence. The predictive model generated has good diagnostic accuracy in predicting postoperative DI with an area under curve of 0.83.

Conclusion

Greater percent change in serum Na, preoperative serum Na, and performance of craniotomy significantly increased the likelihood of postoperative DI while percent change in USG and meningioma on histopathology were significantly associated with a decreased incidence. The predictive model can be used to generate a scoring system in estimating the risk of postoperative DI.

Citations

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    Abera Chanie, Abat Sahlu
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    Mykha Marie B. Tabuzo, Mary Angeline Luz U. Hernandez, Annabell E. Chua, Patricia D. Maningat, Harold Henrison C. Chiu, Roland Dominic G. Jamora
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    Karlos Acurio, Fritz Fidel Váscones-Román, Fernando Canazas-Paredes, Aryan Wadhwa, Niels Pacheco-Barrios
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    Josh Ma, Peter Gooderham, Ryojo Akagami, Serge Makarenko
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    Kunzhe Lin, Kaichun Fan, Shuwen Mu, Shousen Wang
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    Liang Xue, Jianwu Wu, Jie Chen, Yongkai Yang
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    Emily K Brooks, Warrick J Inder
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    Kunzhe Lin, Jun Li, Lingling Lu, Shangming Zhang, Shuwen Mu, Zhijie Pei, Cheng Wang, Jingying Lin, Liang Xue, Liangfeng Wei, Lin Zhao, Shousen Wang
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    Ujjwala Murkute
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Close layer
Clinical Study
Disease-Specific Mortality of Differentiated Thyroid Cancer Patients in Korea: A Multicenter Cohort Study
Min Ji Jeon, Won Gu Kim, Tae Hyuk Kim, Hee Kyung Kim, Bo Hyun Kim, Hyon-Seung Yi, Eun Sook Kim, Hosu Kim, Young Nam Kim, Eun Heui Kim, Tae Yong Kim, Sun Wook Kim, Ho-Cheol Kang, Jae Hoon Chung, Young Kee Shong, Won Bae Kim
Endocrinol Metab. 2017;32(4):434-441.   Published online November 22, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.434
  • 6,058 View
  • 53 Download
  • 29 Web of Science
  • 26 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Little is known regarding disease-specific mortality of differentiated thyroid cancer (DTC) patients and its risk factors in Korea.

Methods

We retrospectively reviewed a large multi-center cohort of thyroid cancer from six Korean hospitals and included 8,058 DTC patients who underwent initial surgery between 1996 and 2005.

Results

Mean age of patients at diagnosis was 46.2±12.3 years; 87% were females. Most patients had papillary thyroid cancer (PTC; 97%) and underwent total thyroidectomy (85%). Mean size of the primary tumor was 1.6±1.0 cm. Approximately 40% of patients had cervical lymph node (LN) metastases and 1.3% had synchronous distant metastases. During 11.3 years of follow-up, 150 disease-specific mortalities (1.9%) occurred; the 10-year disease-specific survival (DSS) rate was 98%. According to the year of diagnosis, the number of disease-specific mortality was not different. However, the rate of disease-specific mortality decreased during the study period (from 7.7% to 0.7%). Older age (≥45 years) at diagnosis, male, follicular thyroid cancer (FTC) versus PTC, larger tumor size (>2 cm), presence of extrathyroidal extension (ETE), lateral cervical LN metastasis, distant metastasis and tumor node metastasis (TNM) stage were independent risk factors of disease-specific mortality of DTC patients.

Conclusion

The rate of disease-specific mortality of Korean DTC patients was 1.9%; the 10-year DSS rate was 98% during 1996 to 2005. Older age at diagnosis, male, FTC, larger tumor size, presence of ETE, lateral cervical LN metastasis, distant metastasis, and TNM stages were significant risk factors of disease-specific mortality of Korean DTC patients.

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Close layer
Clinical Study
Changes in Body Composition According to Age and Sex among Young Non-Diabetic Korean Adults: The Kangbuk Samsung Health Study
Seul-Ki Kim, Yu-Hyun Kwon, Jung Hwan Cho, Da Young Lee, Se Eun Park, Hyung-Geun Oh, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
Endocrinol Metab. 2017;32(4):442-450.   Published online November 21, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.442
  • 6,562 View
  • 64 Download
  • 18 Web of Science
  • 20 Crossref
AbstractAbstract PDFPubReader   
Background

Age-related decreases in lean mass represent a serious health problem. We aimed to analyze the risks of rapid decreases in lean mass by age and sex in relatively young Korean adults during a 4-year follow-up study.

Methods

A total of 65,856 non-diabetic participants (59.5% men, mean age 39.1 years) in a health screening program were subjected to bioimpedance body composition analyses and metabolic parameter analyses at baseline and after 4 years. The participants were sub-divided according to age, and additionally to six groups by age and the degree of body weight change over the 4-year period. The actual changes in body weight, lean mass, and fat mass and the percent changes over the 4-year period were assessed.

Results

The percent change in lean mass decreased and the percent change of fat mass increased with increasing age in every age and sex group. However, the annual percent decrease in lean mass and percent increase in fat mass were significantly higher among women than among men (−0.26% vs. −0.15% and 0.34% vs. 0.42%, respectively; P<0.01). Participants who were older than 50 years and had a weight loss <−5% during the 4 years had significantly greater decreases in lean mass and smaller decreases in fat mass, compared to those who were younger than 50 years. An odds ratio analysis to determine the lowest quartile of the percent change in lean mass according to age group revealed that participants older than 60 years had a significantly increased risk of a rapid decrease in the lean mass percentage (2.081; 95% confidence interval, 1.678 to 2.581).

Conclusion

Even in this relatively young study population, the lean mass decreased significantly with age, and the risk of a rapid decrease in lean mass was higher among women than among men. Furthermore, the elderly exhibited a significantly more rapid decrease in lean mass, compared with younger participants.

Citations

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  • Obesity, Physical Performance, Balance Confidence, and Falls in Community-Dwelling Older Adults: Results from the Korean Frailty and Aging Cohort Study
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    Scientific Reports.2020;[Epub]     CrossRef
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    Kumar Sarvottam, Prabhat Ranjan, Umashree Yadav
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    Ayoung Jeong, Medea Imboden, Akram Ghantous, Alexei Novoloaca, Anne-Elie Carsin, Manolis Kogevinas, Christian Schindler, Gianfranco Lovison, Zdenko Herceg, Cyrille Cuenin, Roel Vermeulen, Deborah Jarvis, André F. S. Amaral, Florian Kronenberg, Paolo Vinei
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    European Geriatric Medicine.2019; 10(5): 801.     CrossRef
  • Low lean tissue mass can be a predictor of one-year survival in hemodialysis patients
    Aleksandra Rymarz, Julia Gibińska, Maria Zajbt, Wiesław Piechota, Stanisław Niemczyk
    Renal Failure.2018; 40(1): 231.     CrossRef
  • Relationship Between Relative Skeletal Muscle Mass and Nonalcoholic Fatty Liver Disease: A 7‐Year Longitudinal Study
    Gyuri Kim, Seung‐Eun Lee, You‐Bin Lee, Ji Eun Jun, Jiyeon Ahn, Ji Cheol Bae, Sang‐Man Jin, Kyu Yeon Hur, Jae Hwan Jee, Moon‐Kyu Lee, Jae Hyeon Kim
    Hepatology.2018; 68(5): 1755.     CrossRef
  • Association between abdominal obesity and increased risk for the development of hypertension regardless of physical activity: A nationwide population‐based study
    Eun‐Jung Rhee, Jung‐Hwan Cho, Hyemi Kwon, Se‐Eun Park, Jin‐Hyung Jung, Kyung‐Do Han, Yong‐Gyu Park, Hye Soon Park, Yang‐Hyun Kim, Soon‐Jib Yoo, Won‐Young Lee
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    Chrysoula Boutari, Christos S. Mantzoros
    Endocrinology and Metabolism.2017; 32(4): 422.     CrossRef
Close layer
Clinical Study
Effects of Single Vitamin D3 Injection (200,000 Units) on Serum Fibroblast Growth Factor 23 and Sclerostin Levels in Subjects with Vitamin D Deficiency
Dongdong Zhang, Da Hea Seo, Han Seok Choi, Hye-Sun Park, Yoon-Sok Chung, Sung-Kil Lim
Endocrinol Metab. 2017;32(4):451-459.   Published online December 14, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.451
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AbstractAbstract PDFPubReader   
Background

Vitamin D deficiency remains common in all age groups and affects skeletal and non-skeletal health. Fibroblast growth factor 23 is a bone-derived hormone that regulates phosphate and 1,25-dihydroxyvitamin D homeostasis as a counter regulatory factor. 1,25-Dihydroxyvitamin D stimulates fibroblast growth factor 23 synthesis in bone, while fibroblast growth factor 23 suppresses 1,25-dihydroxyvitamin D production in the kidney. The aim of this study was to evaluate the effects of vitamin D3 intramuscular injection therapy on serum fibroblast growth factor 23 concentrations, and several other parameters associated with bone metabolism such as sclerostin, dickkopf-1, and parathyroid hormone.

Methods

A total of 34 subjects with vitamin D deficiency (defined by serum 25-hydroxyvitamin D levels below 20 ng/mL) were randomly assigned to either the vitamin D injection group (200,000 units) or placebo treatment group. Serum calcium, phosphate, urine calcium/creatinine, serum 25-hydroxyvitamin D, fibroblast growth factor 23, sclerostin, parathyroid hormone, and dickkopf-1 levels were serially measured after treatment.

Results

Comparing the vitamin D injection group with the placebo group, no significant changes were observed in serum fibroblast growth factor 23, parathyroid hormone, or dickkopf-1 levels. Serum sclerostin concentrations transiently increased at week 4 in the vitamin D group. However, these elevated levels declined later and there were no statistically significant differences as compared with baseline levels.

Conclusion

Serum fibroblast factor 23, sclerostin, parathyroid hormone, and dickkopf-1 levels were not affected significantly by single intramuscular injection of vitamin D3.

Citations

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  • Effect of vitamin D supplementation on circulating fibroblast growth factor-23 concentration in adults with prediabetes
    Lisa Ceglia, Anastassios G. Pittas, Bess Dawson-Hughes
    Aging Clinical and Experimental Research.2023; 35(3): 525.     CrossRef
  • Fibroblast Growth Factor 23 in COVID-19: An Observational Study
    Athena Myrou, Theodoros Aslanidis, Keli Makedou, Athanasios Mitsianis, Aikaterini Thisiadou, Paraskevi Karalazou, Georgios Chatzopoulos, Anastasios Papadopoulos, Antonios Kalis, Dimitrios Giagkoulis, Fotios Lezgidis, Christos Savopoulos
    Cureus.2023;[Epub]     CrossRef
  • The effect of vitamin D supplementation on serum levels of fibroblast growth factor- 23: A systematic review and meta-analysis of randomized controlled trials
    Fatemeh Meshkini, Sepideh Soltani, Cain C.T. Clark, Vivian Tam, David Meyre, Omid Toupchian, Sahar Saraf-Bank, Shima Abdollahi
    The Journal of Steroid Biochemistry and Molecular Biology.2022; 215: 106012.     CrossRef
  • Serum sclerostin levels in osteoporotic fracture patients
    Erwin A. Gorter, Casper R. Reinders, Pieta Krijnen, Natasha M. Appelman-Dijkstra, Inger B. Schipper
    European Journal of Trauma and Emergency Surgery.2022; 48(6): 4857.     CrossRef
  • Clinical Utility of Preoperative Vitamin D3 Injection for Preventing Transient Hypocalcemia after Total Thyroidectomy
    Kwangsoon Kim, Cho Rok Lee, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung, Claudio Casella
    International Journal of Endocrinology.2021; 2021: 1.     CrossRef
  • The effect of vitamin D supplementation on fibroblast growth factor‐23 in patients with chronic kidney disease: A systematic review and meta‐analysis
    Elmira Karimi, Sama Bitarafan, Seyed Mohammad Mousavi, Nikan Zargarzadeh, Pari Mokhtari, Jessie Hawkins, Alipasha Meysamie, Fariba Koohdani
    Phytotherapy Research.2021; 35(10): 5339.     CrossRef
  • Pharmacodynamics of Oral Cholecalciferol in Healthy Individuals with Vitamin D Deficiency: A Randomized Open-Label Study
    Angelo Fassio, Davide Gatti, Maurizio Rossini, Camilla Benini, Elena Fracassi, Eugenia Bertoldo, Ombretta Viapiana, Stefano Milleri, Matteo Gatti, Giovanni Adami
    Nutrients.2021; 13(7): 2293.     CrossRef
  • Vitamin D Deficiency at Mid-Pregnancy Is Associated with a Higher Risk of Postpartum Glucose Intolerance in Women with Gestational Diabetes Mellitus
    Kyung-Soo Kim, Seok Won Park, Yong-Wook Cho, Soo-Kyung Kim
    Endocrinology and Metabolism.2020; 35(1): 97.     CrossRef
  • Effects of vitamin D supplementation on bone turnover markers and other bone-related substances in subjects with vitamin D deficiency
    Rolf Jorde, Astrid Kamilla Stunes, Julia Kubiak, Ragnar Joakimsen, Guri Grimnes, Per Medbøe Thorsby, Unni Syversen
    Bone.2019; 124: 7.     CrossRef
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Close layer
Clinical Study
Detection of Polyethylene Glycol Thyrotropin (TSH) Precipitable Percentage (Macro-TSH) in Patients with a History of Thyroid Cancer
Massimo Giusti, Lucia Conte, Anna Maria Repetto, Stefano Gay, Paola Marroni, Miranda Mittica, Michele Mussap
Endocrinol Metab. 2017;32(4):460-465.   Published online December 14, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.460
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AbstractAbstract PDFPubReader   
Background

Owing to its large molecular size, polyethylene glycol (PEG)-precipitable thyrotropin (TSH) can accumulate in the circulation, elevating TSH levels. PEG-precipitable TSH can be used to detect macro-TSH (mTSH) in serum. Our aim was to evaluate the prevalence of mTSH in patients who had undergone thyroidectomy for thyroid cancer.

Methods

Seventy-three thyroid cancer patients and 24 control subjects on levothyroxine (LT4) TSH-suppressive or replacement therapy were evaluated. Screening for mTSH was performed by adding PEG to serum in order to precipitate γ-globulin. A percentage of PEG-precipitable TSH ≥80% was considered suggestive of mTSH.

Results

No correlation between free-T4 (fT4) and TSH levels was found. PEG-precipitable TSH was 39.3%±1.9% in thyroid cancer patients and 44.1%±3.9% in controls. Macro-TSH was deemed to be present in one thyroid cancer patient and in two control subjects. Only in the thyroid cancer group was PEG-precipitable TSH found to be negatively correlated with fT4 concentration. No correlation was found between PEG-precipitable TSH and other clinical conditions in any patients.

Conclusion

The presence of mTSH seems to be a rare phenomenon in thyroid cancer. In some patients with low PEG-precipitable TSH, a reduction in LT4 dosage could be suggested. LT4 dosage adjusted to body weight is the main factor in maintaining TSH in a semi-suppressed or normal range. Evaluation of mTSH could be necessary in patients in whom a balance is required between adequate TSH suppression and the avoidance of unnecessary exogenous hyperthyroxinemia.

Citations

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  • Prevalence and Pathogenesis of Macro-Thyrotropin in Neonates: Analysis of Umbilical Cord Blood from 939 Neonates and Their Mothers
    Naoki Hattori, Kohzo Aisaka, Ayato Yamada, Takeshi Matsuda, Akira Shimatsu
    Thyroid.2023; 33(1): 45.     CrossRef
  • Pars Distalis and Pars Tuberalis Thyroid-Stimulating Hormones and Their Roles in Macro-Thyroid-Stimulating Hormone Formation
    Eleonore Fröhlich, Richard Wahl
    International Journal of Molecular Sciences.2023; 24(14): 11699.     CrossRef
  • Falsely Elevated Thyroid Stimulating Hormone in Two Cases Requiring Special Follow-up
    Serpil YANIK ÇOLAK, Eray ÖZGÜN, Burak ANDAÇ, Mine OKUR, Buket YILMAZ BÜLBÜL, Mehmet ÇELİK
    Namık Kemal Tıp Dergisi.2023; 11(4): 395.     CrossRef
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    Marsida Teliti, Eleonora Monti, Martina Comina, Lucia Conte, Lara Vera, Stefano Gay, Giorgia Saccomani, Diego Ferone, Massimo Giusti
    Endocrine.2021; 73(2): 347.     CrossRef
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    Cem Onur Kirac, Sedat Abusoglu, Esra Paydas Hataysal, Aysegul Kebapcilar, Suleyman Hilmi Ipekci, Ali Ünlü, Levent Kebapcilar
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Close layer
Clinical Study
Characteristics of Korean Patients with Primary Adrenal Insufficiency: A Registry-Based Nationwide Survey in Korea
A Ram Hong, Ohk-Hyun Ryu, Seong Yeon Kim, Sang Wan Kim
Endocrinol Metab. 2017;32(4):466-474.   Published online December 14, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.466
  • 6,136 View
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  • 14 Web of Science
  • 12 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Primary adrenal insufficiency (PAI) is a rare, potentially life-threatening condition. There are few Korean studies on PAI, and most have had small sample sizes. We aimed to examine the etiology, clinical characteristics, treatment, and mortality of PAI in Korean patients.

Methods

A nationwide, multicenter, registry-based survey was conducted to identify adults diagnosed with or treated for PAI at 30 secondary or tertiary care institutions in Korea between 2000 and 2014.

Results

A total of 269 patients with PAI were identified. The prevalence of PAI was 4.17 per million. The estimated incidence was 0.45 per million per year. The mean age at diagnosis was 49.0 years, and PAI was more prevalent in men. Adrenal tuberculosis was the most common cause of PAI in patients diagnosed before 2000; for those diagnosed thereafter, adrenal metastasis and tuberculosis were comparable leading causes. The etiology of PAI was not identified in 34.9% of cases. Of the patients receiving glucocorticoid replacement therapy, prednisolone was more frequently administered than hydrocortisone (69.4% vs. 26.5%, respectively), and only 27.1% of all patients received fludrocortisone. We observed an increased prevalence of metabolic disease and osteoporosis during the follow-up period (median, 60.2 months). The observed overall mortality and disease-specific mortality rates were 11.9% and 3.1%, respectively.

Conclusion

The prevalence of PAI is significantly lower in Koreans than in reports from Western countries. The high frequency undetermined etiology in patients with PAI suggests the need to reveal accurate etiology of PAI in Korea.

Citations

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    Ying Duan, Wanqi Zheng, Yu Xia, Huiwen Zhang, Lili Liang, Ruifang Wang, Yi Yang, Kaichuang Zhang, Deyun Lu, Yuning Sun, Lianshu Han, Yongguo Yu, Xuefan Gu, Yu Sun, Bing Xiao, Wenjuan Qiu
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    Marianne Øksnes, Eystein S Husebye
    The Journal of Clinical Endocrinology & Metabolism.2023; 109(1): 269.     CrossRef
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    Joonatan Borchers, Eero Pukkala, Outi Mäkitie, Saila Laakso
    The Journal of Clinical Endocrinology & Metabolism.2023; 108(11): 2879.     CrossRef
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    Kasumi Nishikawa, Mizuki Nitta, Shoma Tanaka, Chiaki Sano, Ryuichi Ohta
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    Eystein S Husebye, Simon H Pearce, Nils P Krone, Olle Kämpe
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    A. M. Isidori, G. Arnaldi, M. Boscaro, A. Falorni, C. Giordano, R. Giordano, R. Pivonello, C. Pozza, E. Sbardella, C. Simeoli, C. Scaroni, A. Lenzi
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    Yun Kyung Cho, Seo-Young Lee, Sang-Wook Kim
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    Eun-Jung Rhee, Jung Hee Kim, Sun Joon Moon, Won-Young Lee
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  • Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency
    Kathrin R Frey, Tina Kienitz, Julia Schulz, Manfred Ventz, Kathrin Zopf, Marcus Quinkler
    Endocrine Connections.2018; 7(6): 811.     CrossRef
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    A Hellesen, E Bratland
    Clinical and Experimental Immunology.2018; 195(1): 52.     CrossRef
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    Shannon Cole
    Nursing Clinics of North America.2018; 53(3): 385.     CrossRef
Close layer
Endocrine Research
Rebound Feeding in the Wake of Short-Term Suspension of Food Intake Differs in the Presence of Estrous Cycle Peak versus Nadir Levels of Estradiol
Manita Shakya, Karen P. Briski
Endocrinol Metab. 2017;32(4):475-484.   Published online December 14, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.475
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AbstractAbstract PDFPubReader   
Background

Short-term interruption of feeding is ordinary in modern life but negatively impacts appetite control and body weight. Estradiol (E) imposes long-term inhibitory tonus on food consumption; however, E influence on energy repletion secondary to food deprivation (FD) is unclear. This study investigated the hypothesis that E signal strength regulates hyperphagic responses to FD of varying duration.

Methods

Ovariectomized female rats were implanted with E-containing silastic capsules (30 [E-30] or 300 µg [E-300]/mL) to replicate plasma concentrations at cycle nadir versus peak levels.

Results

Data show that food intake was increased equally in E-30 and E-300 rats after 12 hours of food deprivation (FD-12); yet, FD of 18 hours (FD-18) amplified refeeding by E-300 versus E-30. Caudal fourth ventricular administration of the 5′-monophosphate-activated protein kinase (AMPK) inhibitor compound C (Cc) did not modify FD-induced hyperphagia in E-30 (regardless of FD interval) or E-300 animals exposed to FD-12, but diminished refeeding after FD-18 in E-300 rats. Cc-reversible hyperglycemia occurred in refed FD-18 groups. Serum insulin was resistant to FD-12 plus refeeding, but was elevated by AMPK-dependent mechanisms in refed E-300 FD-18 rats; equivalent Cc-insensitive decrements in circulating leptin occurred in all FD groups.

Conclusion

Current results show that estrous cycle peak, but not baseline, E levels engage hindbrain AMPK signaling to intensify hyperphagia in response to prolongation of FD. Observations of hindbrain AMPK-dependent hyperglycemia, alongside elevated insulin secretion, in refed rats exposed to FD-18 implicate this sensor in insulin resistance mechanisms of glucose partitioning in response to this metabolic imbalance.

Citations

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  • A Framework for Developing Translationally Relevant Animal Models of Stress-Induced Changes in Eating Behavior
    Marie François, Olaya Fernández-Gayol, Lori M. Zeltser
    Biological Psychiatry.2022; 91(10): 888.     CrossRef
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    Marie Francois, Isabella Canal Delgado, Nikolay Shargorodsky, Cheng-Shiun Leu, Lori Zeltser
    eLife.2022;[Epub]     CrossRef
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Erratum
Erratum: Correction of Figure. The Implication of Coronary Artery Calcium Testing for Cardiovascular Disease Prevention and Diabetes
Ron Blankstein, Ankur Gupta, Jamal S. Rana, Khurram Nasir
Endocrinol Metab. 2017;32(4):487.   Published online December 14, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.487
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Endocrinol Metab : Endocrinology and Metabolism