Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Previous issues

Page Path
HOME > BROWSE ARTICLES > Previous issues
13 Previous issues
Filter
Filter
Article type
Keywords
Authors
Volume 32(3); September 2017
Prev issue Next issue
Review Articles
Metabolic Surgery in Korea: What to Consider before Surgery
Mi-Kyung Kim, Yoonseok Heo
Endocrinol Metab. 2017;32(3):307-315.   Published online September 18, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.3.307
  • 4,998 View
  • 50 Download
  • 1 Crossref
AbstractAbstract PDFPubReader   

Obesity is increasing globally and represents a significant global health problem because it predisposes towards various diseases, such as type 2 diabetes mellitus, cardiovascular disease, degenerative joint disease, and certain types of cancer. Numerous studies have shown that bariatric surgery reduces body mass and ameliorates obesity-related complications, such as hypertension and hyperglycemia, suggesting that surgery is the most effective therapeutic option for severely obese and obese diabetic patients. Recent international guidelines recommend surgical treatment for diabetic patients with class III obesity (body mass index [BMI] >40 kg/m2), regardless of their level of glycemic control or the complexity of their glucose-lowering regimens, and for patients with class II obesity (BMI 35.0 to 39.9 kg/m2) and hyperglycemia that is poorly controlled despite appropriate lifestyle and pharmacological therapy. The most popular procedures are Roux-en-Y gastric bypass and sleeve gastrectomy, but new procedures with better outcomes have been reported. For optimal surgical outcome, comprehensive management including assessments of a medical condition, nutrition, mental health, and social support is needed before and after surgery. However, there is still a lack of understanding regarding metabolic surgery in Korea. Therefore, this article reviews indications for metabolic surgery in patients with a specific focus on the situation in Korea.

Citations

Citations to this article as recorded by  
  • Relationship between peak expiratory flow and impaired functional capacity in obese individuals
    Graziele Mayra Santos Moreira, Angela Maria Ribeiro, Patrícia Maria de Melo Carvalho, Pedro Augusto de Carvalho Mira, Isabelle Magalhães Guedes Freitas
    Fisioterapia em Movimento.2021;[Epub]     CrossRef
Close layer
Effects of Incretin-Based Therapies on Diabetic Microvascular Complications
Yu Mi Kang, Chang Hee Jung
Endocrinol Metab. 2017;32(3):316-325.   Published online September 18, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.3.316
  • 5,528 View
  • 61 Download
  • 12 Web of Science
  • 12 Crossref
AbstractAbstract PDFPubReader   

The morbidity and mortality associated with diabetic complications impose a huge socioeconomic burden worldwide. Therefore, the ultimate goal of managing diabetes mellitus (DM) is to lower the risk of macrovascular complications and highly morbid microvascular complications such as diabetic nephropathy (DN) and diabetic retinopathy (DR). Potential benefits of incretin-based therapies such as glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors on the diabetic macrovascular complications have been recently suggested, owing to their pleiotropic effects on multiple organ systems. However, studies primarily investigating the role of these therapies in diabetic microvascular complications are rare. Nevertheless, preclinical and limited clinical data suggest the potential protective effect of incretin-based agents against DN and DR via their anti-inflammatory, antioxidative, and antiapoptotic properties. Evidence also suggests that these incretin-dependent and independent beneficial effects are not necessarily associated with the glucose-lowering properties of GLP-1 RAs and DPP-4 inhibitors. Hence, in this review, we revisit the preclinical and clinical evidence of incretin-based therapy for DR and DN, the two most common, morbid complications in individuals with DM. In addition, the review discusses a few recent studies raising concerns of aggravating DR with the use of incretin-based therapies.

Citations

Citations to this article as recorded by  
  • Efficacy and Safety of the Utilization of Dipeptidyl Peptidase IV Inhibitors in Diabetic Patients with Chronic Kidney Disease: A Meta-Analysis of Randomized Clinical Trials
    Moeber Mahzari, Muhannad Alqirnas, Moustafa Alhamadh, Faisal Alrasheed, Abdulrahman Alhabeeb, Wedad Al Madani, Hussain Aldera
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 1425.     CrossRef
  • Comparative Effectiveness of Glucagon-Like Peptide-1 Receptor Agonists, Sodium-Glucose Cotransporter 2 Inhibitors, Dipeptidyl Peptidase-4 Inhibitors, and Sulfonylureas for Sight-Threatening Diabetic Retinopathy
    Andrew J. Barkmeier, Jeph Herrin, Kavya Sindhu Swarna, Yihong Deng, Eric C. Polley, Guillermo E. Umpierrez, Rodolfo J. Galindo, Joseph S. Ross, Mindy M. Mickelson, Rozalina G. McCoy
    Ophthalmology Retina.2024; 8(10): 943.     CrossRef
  • Incretin-based therapy: a new horizon in diabetes management
    Malek Zarei, Navideh Sahebi Vaighan, Mohammad Hadi Farjoo, Soosan Talebi, Mohammad Zarei
    Journal of Diabetes & Metabolic Disorders.2024;[Epub]     CrossRef
  • Anti-Inflammatory Effects of GLP-1R Activation in the Retina
    Alessandra Puddu, Davide Maggi
    International Journal of Molecular Sciences.2022; 23(20): 12428.     CrossRef
  • Diabetes and Its Complications: Therapies Available, Anticipated and Aspired
    Anu Grover, Komal Sharma, Suresh Gautam, Srishti Gautam, Monica Gulati, Sachin Kumar Singh
    Current Diabetes Reviews.2021; 17(4): 397.     CrossRef
  • SGLT2 Inhibitors, GLP-1 Agonists, and DPP-4 Inhibitors in Diabetes and Microvascular Complications: A Review
    Christopher El Mouhayyar, Ruba Riachy, Abir Bou Khalil, Asaad Eid, Sami Azar
    International Journal of Endocrinology.2020; 2020: 1.     CrossRef
  • Novel therapeutic agents for the treatment of diabetic kidney disease
    Rachel E. Hartman, P.S.S. Rao, Mariann D. Churchwell, Susan J. Lewis
    Expert Opinion on Investigational Drugs.2020; 29(11): 1277.     CrossRef
  • Nationwide Trends in Pancreatitis and Pancreatic Cancer Risk Among Patients With Newly Diagnosed Type 2 Diabetes Receiving Dipeptidyl Peptidase 4 Inhibitors
    Minyoung Lee, Jiyu Sun, Minkyung Han, Yongin Cho, Ji-Yeon Lee, Chung Mo Nam, Eun Seok Kang
    Diabetes Care.2019; 42(11): 2057.     CrossRef
  • Effects of Dipeptidyl Peptidase-4 Inhibitors on Renal Outcomes in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
    Jae Hyun Bae, Sunhee Kim, Eun-Gee Park, Sin Gon Kim, Seokyung Hahn, Nam Hoon Kim
    Endocrinology and Metabolism.2019; 34(1): 80.     CrossRef
  • Serum adipocytokines are associated with microalbuminuria in patients with type 1 diabetes and incipient chronic complications
    Tomislav Bulum, Marijana Vučić Lovrenčić, Martina Tomić, Sandra Vučković-Rebrina, Vinko Roso, Branko Kolarić, Vladimir Vuksan, Lea Duvnjak
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 496.     CrossRef
  • Protective Effects of Incretin Against Age-Related Diseases
    Di Zhang, Mingzhu Ma, Yueze Liu
    Current Drug Delivery.2019; 16(9): 793.     CrossRef
  • The role of dipeptidylpeptidase-4 inhibitors in management of cardiovascular disease in diabetes; focus on linagliptin
    Annayya R. Aroor, Camila Manrique-Acevedo, Vincent G. DeMarco
    Cardiovascular Diabetology.2018;[Epub]     CrossRef
Close layer
Epigenetic Modifications: Novel Therapeutic Approach for Thyroid Cancer
Xuguang Zhu, Sheue-yann Cheng
Endocrinol Metab. 2017;32(3):326-331.   Published online September 18, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.3.326
  • 4,658 View
  • 41 Download
  • 14 Web of Science
  • 14 Crossref
AbstractAbstract PDFPubReader   

The incidence of thyroid cancer is growing the fastest among all cancers in the United States, especially in women. The number of patients with thyroid neoplasm is part of an even larger number of patients who often need to undergo an operation to exclude a cancer diagnosis. While differentiated thyroid cancer (papillary thyroid cancer and follicular thyroid cancer) accounts for most cases of thyroid cancer and has a relatively good prognosis, effective treatments for patients with de-differentiated and anaplastic thyroid cancer are still gravely needed. Despite progress in the identification of genetic changes in thyroid cancer, the impact of aberrant epigenetic alterations on thyroid cancer remains to be fully elucidated. Understanding of the roles of epigenetic changes in thyroid cancer could open new opportunities for the identification of innovative molecular targets for novel treatment modalities, especially for anaplastic thyroid cancer for which treatment is very limited. This article briefly reviews the studies that exemplify the potential for and promise of using epigenetic regulators in the treatment of thyroid cancer.

Citations

Citations to this article as recorded by  
  • Challenges and Coping Strategies of Older Adults in the Aftermath of Kahramanmaraş Earthquake in Türkiye: A Qualitative Research
    Nilgun Kuru Alici, Bilge Kalanlar
    Journal of Applied Gerontology.2024; 43(10): 1580.     CrossRef
  • The role of epigenetic methylations in thyroid Cancer
    Xiaojie Yu, Hao Zhang, Haojie Zhang, Changran Hou, Xiaohong Wang, Pengfei Gu, Yong Han, Zhenlin Yang, Weiwei Zou
    World Journal of Surgical Oncology.2024;[Epub]     CrossRef
  • CircRTN1 stimulates HMGB1 to regulate the malignant progression of papillary thyroid cancer by sponging miR-101-3p
    Mei Zheng, Lingli Xu, Cuifeng Wei, Wenzhen Guan
    Hormones.2023; 22(2): 281.     CrossRef
  • The expression of HDAC9 and P300 in papillary thyroid carcinoma cell line
    Hatice Ozisik, Berrin Ozdil, Aslı Suner, Murat Sipahi, Mehmet Erdogan, Sevki Cetinkalp, Gokhan Ozgen, Fusun Saygili, Gulgun Oktay, Huseyin Aktug
    Pathology - Research and Practice.2023; 243: 154385.     CrossRef
  • Dynamic Cancer Cell Heterogeneity: Diagnostic and Therapeutic Implications
    Valerie Jacquemin, Mathieu Antoine, Geneviève Dom, Vincent Detours, Carine Maenhaut, Jacques E. Dumont
    Cancers.2022; 14(2): 280.     CrossRef
  • Thyroid Carcinoma: A Review for 25 Years of Environmental Risk Factors Studies
    Eva Kruger, Eman A. Toraih, Mohammad H. Hussein, Shaimaa A. Shehata, Amani Waheed, Manal S. Fawzy, Emad Kandil
    Cancers.2022; 14(24): 6172.     CrossRef
  • Study of Essential and Toxic Metal Imbalances in the Scalp Hair of Thyroid Cancer Patients in Comparison with Healthy Donors
    Kalsoom Bibi, Munir H. Shah
    Biological Trace Element Research.2021; 199(2): 500.     CrossRef
  • Modern concepts of the molecular pathogenesis of thyroid cancer
    A. A. Mikhailova, A. V. Shestakov, K. A. Chubakova, E. V. Kolokolova, V. Yu. Eliseev, M. Ya. Kostyaeva, E. G. Akperov, V. E. Pilipenko, T. V. Saprina, M. R. Mukhamedov, E. L. Choinzonov
    Advances in Molecular Oncology.2021; 8(2): 8.     CrossRef
  • Effect of valproic acid on miRNAs affecting histone deacetylase in a model of anaplastic thyroid cancer
    Nur Selvi Gunel, Nihal Birden, Cansu Caliskan Kurt, Bakiye Goker Bagca, Behrouz Shademan, Fatma Sogutlu, Neslihan Pinar Ozates, Cigir Biray Avci
    Molecular Biology Reports.2021; 48(8): 6085.     CrossRef
  • Histone Deacetylase Inhibitors and Papillary Thyroid Cancer
    Eleftherios Spartalis, Konstantinos Kotrotsios, Dimosthenis Chrysikos, Michael Spartalis, Stavroula A. Paschou, Dimitrios Schizas, Konstantinos Tsamakis, Dimitrios Dimitroulis, Theodore Troupis, Nikolaos Nikiteas
    Current Pharmaceutical Design.2021; 27(18): 2199.     CrossRef
  • HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer
    Ching-Ling Lin, Ming-Lin Tsai, Chun-Yu Lin, Kai-Wen Hsu, Wen-Shyang Hsieh, Wei-Ming Chi, Li-Chi Huang, Chia-Hwa Lee
    International Journal of Molecular Sciences.2019; 20(2): 454.     CrossRef
  • Systems Biology Approaches to Investigate Genetic and Epigenetic Molecular Progression Mechanisms for Identifying Gene Expression Signatures in Papillary Thyroid Cancer
    Shan-Ju Yeh, Chien-Yu Lin, Cheng-Wei Li, Bor-Sen Chen
    International Journal of Molecular Sciences.2019; 20(10): 2536.     CrossRef
  • Human telomerase reverse transcriptase in papillary thyroid cancer: gene expression, effects of silencing and regulation by BET inhibitors in thyroid cancer cells
    Valentina Maggisano, Marilena Celano, Saverio Massimo Lepore, Marialuisa Sponziello, Francesca Rosignolo, Valeria Pecce, Antonella Verrienti, Federica Baldan, Catia Mio, Lorenzo Allegri, Marianna Maranghi, Rosa Falcone, Giuseppe Damante, Diego Russo, Stef
    Endocrine.2019; 63(3): 545.     CrossRef
  • Role of Emerging Environmental Risk Factors in Thyroid Cancer: A Brief Review
    Maria Fiore, Gea Oliveri Conti, Rosario Caltabiano, Antonino Buffone, Pietro Zuccarello, Livia Cormaci, Matteo Angelo Cannizzaro, Margherita Ferrante
    International Journal of Environmental Research and Public Health.2019; 16(7): 1185.     CrossRef
Close layer
CTNNB1 Mutation in Aldosterone Producing Adenoma
Jian-Jhong Wang, Kang-Yung Peng, Vin-Cent Wu, Fen-Yu Tseng, Kwan-Dun Wu
Endocrinol Metab. 2017;32(3):332-338.   Published online September 18, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.3.332
  • 5,782 View
  • 60 Download
  • 10 Web of Science
  • 10 Crossref
AbstractAbstract PDFPubReader   

Discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas (APAs) with distinct clinical presentations and pathological features. Catenin β1 (CTNNB1) mutation in APAs has been recently described and discussed in the literature. However, significant knowledge gaps still remain regarding the prevalence, clinical characteristics, pathophysiology, and outcomes in APA patients harboring CTNNB1 mutations. Aberrant activation of the Wnt/β-catenin signaling pathway will further modulate tumorigenesis. We also discuss the recent knowledge of CTNNB1 mutation in adrenal adenomas.

Citations

Citations to this article as recorded by  
  • Molecular and Genetics Perspectives on Primary Adrenocortical Hyperfunction Disorders
    Sanggu Kim, Preeti Kumari Chaudhary, Soochong Kim
    International Journal of Molecular Sciences.2024; 25(21): 11341.     CrossRef
  • CTNNB1 in neurodevelopmental disorders
    Wenting Zhuang, Tong Ye, Wei Wang, Weihong Song, Tao Tan
    Frontiers in Psychiatry.2023;[Epub]     CrossRef
  • Aldosterone-Regulated Sodium Transport and Blood Pressure
    Akaki Tsilosani, Chao Gao, Wenzheng Zhang
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Pathogenesis of Primary Aldosteronism: Impact on Clinical Outcome
    Lucas S. Santana, Augusto G. Guimaraes, Madson Q. Almeida
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway
    Hiroki Shimada, Yuto Yamazaki, Akira Sugawara, Hironobu Sasano, Yasuhiro Nakamura
    Biomedicines.2021; 9(8): 892.     CrossRef
  • Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause
    Junhua Zhou, Elena A. B. Azizan, Claudia P. Cabrera, Fabio L. Fernandes-Rosa, Sheerazed Boulkroun, Giulia Argentesi, Emily Cottrell, Laurence Amar, Xilin Wu, Sam O’Toole, Emily Goodchild, Alison Marker, Russell Senanayake, Sumedha Garg, Tobias Åkerström,
    Nature Genetics.2021; 53(9): 1360.     CrossRef
  • Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation
    Emanuele Pignatti, Sining Leng, Yixing Yuchi, Kleiton S. Borges, Nick A. Guagliardo, Manasvi S. Shah, Gerard Ruiz-Babot, Dulanjalee Kariyawasam, Makoto Mark Taketo, Ji Miao, Paula Q. Barrett, Diana L. Carlone, David T. Breault
    Cell Reports.2020; 31(3): 107524.     CrossRef
  • Genetics and pathophysiology of low-renin arterial hypertension
    A. L. Markel
    Vavilov Journal of Genetics and Breeding.2019; 22(8): 1000.     CrossRef
  • Diagnostic approach to low‐renin hypertension
    Silvia Monticone, Isabel Losano, Martina Tetti, Fabrizio Buffolo, Franco Veglio, Paolo Mulatero
    Clinical Endocrinology.2018; 89(4): 385.     CrossRef
  • Genetic Characterization of GnRH/LH-Responsive Primary Aldosteronism
    Nadia Gagnon, Katia Y Cáceres-Gorriti, Gilles Corbeil, Nada El Ghoyareb, Natasha Ludwig, Mathieu Latour, André Lacroix, Isabelle Bourdeau
    The Journal of Clinical Endocrinology & Metabolism.2018; 103(8): 2926.     CrossRef
Close layer
Calcium and Cardiovascular Disease
Ian R. Reid, Sarah M. Birstow, Mark J. Bolland
Endocrinol Metab. 2017;32(3):339-349.   Published online September 18, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.3.339
  • 13,799 View
  • 180 Download
  • 76 Web of Science
  • 75 Crossref
AbstractAbstract PDFPubReader   

Circulating calcium is a risk factor for vascular disease, a conclusion arising from prospective studies involving hundreds of thousands of participants and extending over periods of up to 30 years. These associations may be partially mediated by other cardiovascular risk factors such as circulating lipid levels, blood pressure, and body mass index, but there appears to be a residual independent effect of serum calcium. Polymorphisms of the calcium-sensing receptor associated with small elevations of serum calcium are also associated with cardiovascular disease, suggesting that calcium plays a causative role. Trials of calcium supplements in patients on dialysis and those with less severe renal failure demonstrate increased mortality and/or acceleration of vascular disease, and meta-analyses of trials in those without overt renal disease suggest a similar adverse effect. Interpretation of the latter trials is complicated by a significant interaction between baseline use of calcium supplements and the effect of randomisation to calcium in the largest trial. Restriction of analysis to those who are calcium-naive demonstrates a consistent adverse effect. Observational studies of dietary calcium do not demonstrate a consistent adverse effect on cardiovascular health, though very high or very low intakes may be deleterious. Thus, obtaining calcium from the diet rather than supplements is to be encouraged.

Citations

Citations to this article as recorded by  
  • Cardiovascular and Cerebrovascular Outcomes With Vitamin D Supplementation: A Systematic Review and Meta-Analysis
    Jishanth Mattumpuram, Muhammad Talha Maniya, Sabeeh Khawar Faruqui, Aymen Ahmed, Vikash Jaiswal, Sreedevi Pallath Harshakumar
    Current Problems in Cardiology.2024; 49(1): 102119.     CrossRef
  • Association of Genotypes of ANGPTL3 with Vitamin D and Calcium Concentration in Cardiovascular Disease
    Malihe Aghasizadeh, Mahmoud Ghanei, Sahar Ghoflchi, Parisa Asadian-sohan, Mohammad Haghani, Tooba Kazemi, Habibollah Esmaily, Amir Avan, Gordon A. Ferns, Ebrahim Miri-Moghaddam, Majid Ghayour-Mobarhan
    Biochemical Genetics.2024; 62(4): 2482.     CrossRef
  • 43Ca MAS-DNP NMR of Frozen Solutions for the Investigation of Calcium Ion Complexation
    Tristan Georges, Romain Chèvre, Samuel F. Cousin, Christel Gervais, Pierre Thureau, Giulia Mollica, Thierry Azaïs
    ACS Omega.2024; 9(4): 4881.     CrossRef
  • Association between Daily Dietary Calcium Intake and the Risk of Cardiovascular Disease (CVD) in Postmenopausal Korean Women
    Jae Kyung Lee, Thi Minh Chau Tran, Euna Choi, Jinkyung Baek, Hae-Rim Kim, Heeyon Kim, Bo Hyon Yun, Seok Kyo Seo
    Nutrients.2024; 16(7): 1043.     CrossRef
  • Osteosarcopenic adiposity (OSA) phenotype and its connection with cardiometabolic disorders: Is there a cause-and-effect?
    Jasminka Z. Ilich, Biljana Pokimica, Danijela Ristić-Medić, Snjezana Petrović, Aleksandra Arsić, Nadja Vasiljević, Vesna Vučić, Owen J. Kelly
    Ageing Research Reviews.2024; 98: 102326.     CrossRef
  • Associations of Dietary Calcium and Phosphorus With Vascular and Valvular Calcification
    Yume Nohara-Shitama, Yejin Mok, Shoshana H. Ballew, Casey M. Rebholz, Matthew J. Budoff, Cheryl Anderson, Junichi Ishigami, Michael J. Blaha, Kunihiro Matsushita
    JACC: Advances.2024; 3(7): 100993.     CrossRef
  • Dietary Minerals and Incident Cardiovascular Outcomes among Never-Smokers in a Danish Case–Cohort Study
    Victoria Fruh, Tesleem Babalola, Clara Sears, Gregory A. Wellenius, Thomas F. Webster, Koren K. Mann, James Harrington, Anne Tjønneland, Ole Raaschou-Nielsen, Birgit Claus Henn, Jaymie R. Meliker
    International Journal of Environmental Research and Public Health.2024; 21(7): 932.     CrossRef
  • Preparation of wheat protein peptides-calcium chelate by the ultrasound method: Structural characteristics and bioactivity
    Mingyi Zhang, Yinchen Hou, Aimei Liao, Xinyang Chen, Zhen Wang, Penghui Zhao, Long Pan, Jihong Huang
    Food Bioscience.2024; 61: 104848.     CrossRef
  • Perioperative Modulation of Left Ventricular Systolic Performance: A Retrospective Study on Ionized Calcium and Vitamin D in Cardiac Surgery Patients
    Adrian Ștef, Constantin Bodolea, Ioana Corina Bocșan, Alexandru Achim, Nadina Tintiuc, Raluca Maria Pop, Aurelia Georgeta Solomonean, Alexandru Manea, Anca Dana Buzoianu
    Journal of Personalized Medicine.2024; 14(8): 850.     CrossRef
  • Emerging Trends in Sports Cardiology: The Role of Micronutrients in Cardiovascular Health and Performance
    Sharma Biswajit, Mukhopadhyay Kishore
    Journal of Sports Medicine and Therapy.2024; 9(3): 073.     CrossRef
  • Serum total calcium levels as a non-linear predictor of in-hospital mortality in heart failure patients: insights from a retrospective cohort study
    Jing Song, Guojuan Xu, Jing Song, Guojuan Xu
    BMC Cardiovascular Disorders.2024;[Epub]     CrossRef
  • Case Series Analysis of Chronic Venous Insufficiency Patients to Determine Associated Arthrosis
    Malay Patel, Roy Varghese, Manjusha Rajarshi
    Indian Journal of Surgery.2023; 85(S1): 106.     CrossRef
  • Prevalence of asteroid hyalosis and systemic risk factors in United States adults
    Ryan Duong, Xiaoyu Cai, Naveen Ambati, Yevgeniy Shildkrot, Rebecca Sieburth
    Eye.2023; 37(8): 1678.     CrossRef
  • L-shaped association of serum calcium with all-cause and CVD mortality in the US adults: A population-based prospective cohort study
    Xinran Hou, Jie Hu, Zhuoyi Liu, E. Wang, Qulian Guo, Zhong Zhang, Zongbin Song
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • The genetic correlation and causal association between key factors that influence vascular calcification and cardiovascular disease incidence
    Xiaolin Ni, Lei Liu, Yao Yao, Chi Zhang, Huabin Su, Yuan Lv, Rongqiao Li, Liang Sun, Qi Zhou, Xiaoquan Zhu, Ze Yang, Zuoguan Chen, Wei He, Huolan Zhu, Shenqi Zhang, Caiyou Hu, Huiping Yuan
    Frontiers in Cardiovascular Medicine.2023;[Epub]     CrossRef
  • The association of long-term calcium and dairy products intake in adolescence with carotid intima media thickness and metabolic syndrome in early adulthood: Tehran Lipid and Glucose Study
    Assa AkbarySedigh, Golaleh Asghari, Maryam Mahdavi, Parvin Mirmiran, Majid Valizadeh, Fereidoun Azizi
    Nutrition & Metabolism.2023;[Epub]     CrossRef
  • Effect Modification of Kidney Function on the Non-linear Association Between Serum Calcium Levels and Cardiovascular Mortality in Korean Adults
    Jung-Ho Yang, Sun-Seog Kweon, Young-Hoon Lee, Seong-Woo Choi, So-Yeon Ryu, Hae-Sung Nam, Hye-Yeon Kim, Min-Ho Shin
    Journal of Preventive Medicine and Public Health.2023; 56(3): 282.     CrossRef
  • The Relationship between Mortality from Cardiovascular Diseases and Total Drinking Water Hardness: Systematic Review with Meta-Analysis
    Aleksandra Bykowska-Derda, Marcin Spychala, Magdalena Czlapka-Matyasik, Mariusz Sojka, Jerzy Bykowski, Mariusz Ptak
    Foods.2023; 12(17): 3255.     CrossRef
  • Association Between Calcium Supplementation and the Risk of Cardiovascular Disease and Stroke: A Systematic Review and Meta-Analysis
    Ming Gin Sim, Yao Neng Teo, Yao Hao Teo, Nicholas L. Syn, Tony Y.W. Li, Leonard L.L. Yeo, William K.F. Kong, Benjamin Y.Q. Tan, James W. Yip, Raymond C.C. Wong, Kian Keong Poh, Tiong-Cheng Yeo, Vijay Kumar Sharma, Ping Chai, Mark Y. Chan, Ching-Hui Sia
    Heart, Lung and Circulation.2023; 32(10): 1230.     CrossRef
  • Omega-3 long-chain polyunsaturated fatty acids: Metabolism and health implications
    Imad Khan, Mudassar Hussain, Bangzhi Jiang, Lei Zheng, Yuechao Pan, Jijie Hu, Adil Khan, Azqa Ashraf, Xiaoqiang Zou
    Progress in Lipid Research.2023; 92: 101255.     CrossRef
  • The role of chromium supplementation in cardiovascular risk factors: A comprehensive reviews of putative molecular mechanisms
    Dhiaa lattef Gossa Al-Saadde, Ali Murtaza Haider, Arsalan Ali, Ebraheem Abdu Musad Saleh, Abduladheem Turki Jalil, Furqan M. Abdulelah, Rosario Mireya Romero-Parra, Nahla A. Tayyib, Andrés Alexis Ramírez-Coronel, Ameer S. Alkhayyat
    Heliyon.2023; 9(9): e19826.     CrossRef
  • Calcium as an essential macronutrient: benefits and risks for cardiovascular and other body systems
    A.V. Gostry, R.A. Bekker, Yu.V. Bykov
    Profilakticheskaya meditsina.2023; 26(10): 109.     CrossRef
  • Bone-friendly lifestyle and the role of calcium or vitamin D supplementation
    I. R. Reid
    Climacteric.2022; 25(1): 37.     CrossRef
  • Cardiovascular risks associated with calcium supplementation in patients with osteoporosis: a nationwide cohort study
    Kyoung Jin Kim, Min Sun Kim, Namki Hong, Jae Hyun Bae, Kyeong Jin Kim, Nam Hoon Kim, Yumie Rhee, Juneyoung Lee, Sin Gon Kim
    European Heart Journal - Cardiovascular Pharmacotherapy.2022; 8(6): 568.     CrossRef
  • Cyclic voltammetric determination of calcium in water in the presence of natural organic matter (humic acid) and Cu (II) at gold electrode's surface
    Olayemi J. Fakayode, Thabo T.I. Nkambule
    Food Chemistry Advances.2022; 1: 100012.     CrossRef
  • Low serum concentration of zinc, selenium, calcium, potassium and high serum concentration of iron, sodium are associated with myocardial infarction
    S. M. Naim Uddin, Md. Zahedur Rahaman, Thanmin Jarana Thammi, Mohammad Rashedul Islam, Md. Iftikhar Uddin Masud, Md. Giash Uddin, Mohammad Safiqul Islam
    Aging and Health Research.2022; 2(1): 100063.     CrossRef
  • Organelle-specific blue-emitting two-photon probes for calcium ions: Combination with green-emitting two-photon probe for simultaneous detection of proton ions
    Seung Taek Hong, Mun Seok Kim, Bo Ra Kim, Eun Jeong Lee, Yeo Uk Yoon, Kyu Cheol Paik, Man So Han, Eun Sun Kim, Bong Rae Cho
    Talanta.2022; 244: 123408.     CrossRef
  • Plasma Calcium and Phosphorus Levels and Cardiovascular Disease Risks in Egyptian Type 2 Diabetic Patients
    Sahar Al-Okbi, Seham Sabry, Enas S. K. Al-Siedy, Shaimaa Elsayed
    Open Access Macedonian Journal of Medical Sciences.2022; 10(A): 502.     CrossRef
  • The Incidence of Serum Calcium Elevation due to Adrenal Insufficiency After Unilateral Adrenalectomy
    Woochul Kim, Jee-Hye Choi, Ja Kyung Lee, Chang Ho Ahn, Hyeong Won Yu, June Young Choi
    Journal of Endocrine Surgery.2022; 22(1): 18.     CrossRef
  • Calcium Supplementation, Risk of Cardiovascular Diseases, and Mortality: A Real-World Study of the Korean National Health Insurance Service Data
    Jae-Min Park, Bora Lee, Young-Sang Kim, Kyung-Won Hong, Yon Chul Park, Dong Hyeok Shin, Yonghwan Kim, Kunhee Han, Kwangyoon Kim, Junghwa Shin, Mina Kim, Bom-Taeck Kim
    Nutrients.2022; 14(12): 2538.     CrossRef
  • Physical Fitness and Dietary Intake Improve Mental Health in Chinese Adolescence Aged 12–13
    Wenjie Liang, Jian Fu, Xin Tian, Jiaxue Tian, Yu Yang, Wencui Fan, Zijuan Du, Zheyu Jin
    Frontiers in Integrative Neuroscience.2022;[Epub]     CrossRef
  • EXTENSIVE EXPERTISE IN ENDOCRINOLOGY: Osteoporosis management
    Ian R Reid
    European Journal of Endocrinology.2022; 187(4): R65.     CrossRef
  • Evaluation of the Increase in Serum Calcium Levels After Unilateral Adrenalectomy
    Mehmet Üstün, Korhan Tuncer
    Cureus.2022;[Epub]     CrossRef
  • Comparing the Evidence from Observational Studies and Randomized Controlled Trials for Nonskeletal Health Effects of Vitamin D
    William B. Grant, Barbara J. Boucher, Fatme Al Anouti, Stefan Pilz
    Nutrients.2022; 14(18): 3811.     CrossRef
  • Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: Role of mitochondria
    Yan Zhong Liu, Zong Xiang Li, Lin Lin Zhang, Dan Wang, Yi Ping Liu
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Association between serum calcium level and in-hospital mortality in patients with acute myocardial infarction: a retrospective cohort study
    Dingfeng Fang, Haibo Chen
    Scientific Reports.2022;[Epub]     CrossRef
  • Calcium and vitamin D supplements for the treatment and prevention of osteoporosis. Should it be widely used?
    Yuliya A. Kaminarskaya
    Clinical nutrition and metabolism.2022; 3(3): 167.     CrossRef
  • Calcium Signalling in Heart and Vessels: Role of Calmodulin and Downstream Calmodulin-Dependent Protein Kinases
    Sofia Beghi, Malgorzata Furmanik, Armand Jaminon, Rogier Veltrop, Nikolas Rapp, Kanin Wichapong, Elham Bidar, Annamaria Buschini, Leon J. Schurgers
    International Journal of Molecular Sciences.2022; 23(24): 16139.     CrossRef
  • Childhood and long-term dietary calcium intake and adult cardiovascular risk in a population with high calcium intake
    Feitong Wu, Katja Pahkala, Markus Juonala, Suvi P. Rovio, Matthew A. Sabin, Tapani Rönnemaa, Kylie J. Smith, Antti Jula, Terho Lehtimäki, Nina Hutri-Kähönen, Mika Kähönen, Tomi Laitinen, Jorma S.A. Viikari, Olli T. Raitakari, Costan G. Magnussen
    Clinical Nutrition.2021; 40(4): 1926.     CrossRef
  • Collagen networks within 3D PEG hydrogels support valvular interstitial cell matrix mineralization
    Megan E. Schroeder, Andrea Gonzalez Rodriguez, Kelly F. Speckl, Cierra J. Walker, Firaol S. Midekssa, Joseph C. Grim, Robert M. Weiss, Kristi S. Anseth
    Acta Biomaterialia.2021; 119: 197.     CrossRef
  • Effects of High-Impact Weight-Bearing Exercise on Bone Mineral Density and Bone Metabolism in Middle-Aged Premenopausal Women: A Randomized Controlled Trial
    Sung-Woo Kim, Myong-Won Seo, Hyun-Chul Jung, Jong-Kook Song
    Applied Sciences.2021; 11(2): 846.     CrossRef
  • Higher Intakes of Potassium and Magnesium, but Not Lower Sodium, Reduce Cardiovascular Risk in the Framingham Offspring Study
    R. Taylor Pickering, M. Loring Bradlee, Martha R. Singer, Lynn L. Moore
    Nutrients.2021; 13(1): 269.     CrossRef
  • Low serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry
    Timo Schmitz, Christian Thilo, Jakob Linseisen, Margit Heier, Annette Peters, Bernhard Kuch, Christa Meisinger
    Scientific Reports.2021;[Epub]     CrossRef
  • Edible Insects versus Meat—Nutritional Comparison: Knowledge of Their Composition Is the Key to Good Health
    Agnieszka Orkusz
    Nutrients.2021; 13(4): 1207.     CrossRef
  • The Role of Essential Oils and Their Main Compounds in the Management of Cardiovascular Disease Risk Factors
    Jorge M. Alves-Silva, Mónica Zuzarte, Henrique Girão, Lígia Salgueiro
    Molecules.2021; 26(12): 3506.     CrossRef
  • Polymorphism rs7214723 in CAMKK1: a new genetic variant associated with cardiovascular diseases
    Sofia Beghi, Francesca Cavaliere, Matteo Manfredini, Sandro Ferrarese, Claudio Corazzari, Cesare Beghi, Annamaria Buschini
    Bioscience Reports.2021;[Epub]     CrossRef
  • The Role of Serum Calcium Levels in Pediatric Dyslipidemia: Are There Any?
    Yaguang Peng, Lixin Hu, Xiaolu Nie, Siyu Cai, Ruohua Yan, Yali Liu, Yanying Cai, Wenqi Song, Xiaoxia Peng
    Frontiers in Pediatrics.2021;[Epub]     CrossRef
  • The impact of serum 25-hydroxyvitamin D, calcium, and parathyroid hormone levels on the risk of coronary artery disease in patients with diabetes: a Mendelian randomization study
    Songzan Chen, Fangkun Yang, Tian Xu, Yao Wang, Kaijie Zhang, Guosheng Fu, Wenbin Zhang
    Nutrition Journal.2021;[Epub]     CrossRef
  • Temporal Relationship Between Changes in Serum Calcium and Hypercholesteremia and Its Impact on Future Brachial-Ankle Pulse Wave Velocity Levels
    Xing Meng, Tianshu Han, Wenbo Jiang, Fengli Dong, Hongxue Sun, Wei Wei, Yageng Yan
    Frontiers in Nutrition.2021;[Epub]     CrossRef
  • The Evidence and Controversy Between Dietary Calcium Intake and Calcium Supplementation and the Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Cohort Studies and Randomized Controlled Trials
    Chao Yang, Xiangling Shi, Hui Xia, Xian Yang, Hechun Liu, Da Pan, Guiju Sun
    Journal of the American College of Nutrition.2020; 39(4): 352.     CrossRef
  • Association between the cumulative exposure to bisphosphonates and hospitalization for atherosclerotic cardiovascular events: A population-based study
    Manuela Casula, Elena Olmastroni, Federica Galimberti, Elena Tragni, Giovanni Corrao, Lorenza Scotti, Alberico L. Catapano
    Atherosclerosis.2020; 301: 1.     CrossRef
  • Calcium and/or Vitamin D Supplementation for the Prevention of Fragility Fractures: Who Needs It?
    Ian R Reid, Mark J Bolland
    Nutrients.2020; 12(4): 1011.     CrossRef
  • Oxalates, urinary stones and risk of cardiovascular diseases
    Ahmed Arafa, Ehab S. Eshak, Hiroyasu Iso
    Medical Hypotheses.2020; 137: 109570.     CrossRef
  • A dual signal on-off fluorescent nanosensor for the simultaneous detection of copper and creatinine
    Resmi V. Nair, Parvathy Radhakrishna Pillai Suma, Ramapurath S. Jayasree
    Materials Science and Engineering: C.2020; 109: 110569.     CrossRef
  • Soy isoflavones interact with calcium and contribute to blood pressure homeostasis in women: a randomized, double-blind, placebo controlled trial
    Lee-Jane W. Lu, Nai-Wei Chen, Fatima Nayeem, Manubai Nagamani, Karl E. Anderson
    European Journal of Nutrition.2020; 59(6): 2369.     CrossRef
  • Associations between diet and mental health using the 12-item General Health Questionnaire: cross-sectional and prospective analyses from the Japan Multi-Institutional Collaborative Cohort Study
    Naoki Choda, Kenji Wakai, Mariko Naito, Nahomi Imaeda, Chiho Goto, Kenta Maruyama, Yuka Kadomatsu, Mineko Tsukamoto, Tae Sasakabe, Yoko Kubo, Rieko Okada, Sayo Kawai, Takashi Tamura, Asahi Hishida, Kenji Takeuchi, Atsuyoshi Mori, Nobuyuki Hamajima
    Nutrition Journal.2020;[Epub]     CrossRef
  • Vitamin D supplementation and incident preeclampsia: A systematic review and meta-analysis of randomized clinical trials
    Silvia Fogacci, Federica Fogacci, Maciej Banach, Erin D. Michos, Adrian V. Hernandez, Gregory Y.H. Lip, Michael J. Blaha, Peter P. Toth, Claudio Borghi, Arrigo F.G. Cicero
    Clinical Nutrition.2020; 39(6): 1742.     CrossRef
  • Establishing Benefit from Vitamin D Supplementation — Adherence to Defined Criteria and Targeting of High-Risk Groups Essential?
    Siobhán McGettigan, P. Mulkerrin, P.M. O'Shea, S.T. O'Keeffe, E.C. Mulkerrin
    The Journal of nutrition, health and aging.2020; 24(8): 827.     CrossRef
  • Nutritional Quality and Health Effects of Low Environmental Impact Diets: The “Seguimiento Universidad de Navarra” (SUN) Cohort
    Ujué Fresán, Winston J. Craig, Miguel A. Martínez-González, Maira Bes-Rastrollo
    Nutrients.2020; 12(8): 2385.     CrossRef
  • Beyond Fish Oil Supplementation: The Effects of Alternative Plant Sources of Omega-3 Polyunsaturated Fatty Acids upon Lipid Indexes and Cardiometabolic Biomarkers—An Overview
    Heitor O. Santos, James C. Price, Allain A. Bueno
    Nutrients.2020; 12(10): 3159.     CrossRef
  • Oxidative stress by Ca2+ overload is critical for phosphate-induced vascular calcification
    Nhung Thi Nguyen, Tuyet Thi Nguyen, Dat Da Ly, Jing-Bo Xia, Xu-Feng Qi, In-Kyu Lee, Seung-Kuy Cha, Kyu-Sang Park
    American Journal of Physiology-Heart and Circulatory Physiology.2020; 319(6): H1302.     CrossRef
  • A Naringin- and Icariin-Contained Herbal Formula, Gushukang, Ameliorated Aged Osteoporosis of Aged Mice with High Calcium Intake
    Xiao-Li Li, Fei Xu, Fu-Hui Lin, Lian-Zhong Ai, Yong-Jian Zhao, Xiao-Lei Bi, Li Sui, Yan Zhang
    The American Journal of Chinese Medicine.2020; 48(07): 1671.     CrossRef
  • Gushukang exerts osteopreserve effects by regulating vitamin D and calcium metabolism in ovariectomized mice
    Xiao-Li Li, Liang Wang, Xiao-Lei Bi, Bing-Bing Chen, Yan Zhang
    Journal of Bone and Mineral Metabolism.2019; 37(2): 224.     CrossRef
  • Genetic predisposition to increased serum calcium, bone mineral density, and fracture risk in individuals with normal calcium levels: mendelian randomisation study
    Agustin Cerani, Sirui Zhou, Vincenzo Forgetta, John A Morris, Katerina Trajanoska, Fernando Rivadeneira, Susanna C Larsson, Karl Michaëlsson, J Brent Richards
    BMJ.2019; : l4410.     CrossRef
  • Protective Effects of Phenylpropanoids and Phenylpropanoid-rich Essential Oils on the Cardiovascular System
    Jorge M. Alves-Silva, Mónica Zuzarte, Carla Marques, Henrique Girão, Lígia Salgueiro
    Mini-Reviews in Medicinal Chemistry.2019; 19(17): 1459.     CrossRef
  • Borderline high serum calcium levels are associated with arterial stiffness and 10‐year cardiovascular disease risk determined by Framingham risk score
    Byoungjin Park, Yong‐Jae Lee
    The Journal of Clinical Hypertension.2019; 21(5): 668.     CrossRef
  • Effects of IGF-1 on the Cardiovascular System
    Milan Obradovic, Sonja Zafirovic, Sanja Soskic, Julijana Stanimirovic, Andreja Trpkovic, Danimir Jevremovic, Esma R. Isenovic
    Current Pharmaceutical Design.2019; 25(35): 3715.     CrossRef
  • Associations between serum calcium, 25(OH)D level and bone mineral density in older adults
    Minbo Liu, Xiaocong Yao, Zhongxin Zhu
    Journal of Orthopaedic Surgery and Research.2019;[Epub]     CrossRef
  • Controversies in medicine: the role of calcium and vitamin D supplements in adults
    Ian R Reid, Mark J Bolland
    Medical Journal of Australia.2019; 211(10): 468.     CrossRef
  • Structural insight into TRPV5 channel function and modulation
    Shangyu Dang, Mark K. van Goor, Daniel Asarnow, YongQiang Wang, David Julius, Yifan Cheng, Jenny van der Wijst
    Proceedings of the National Academy of Sciences.2019; 116(18): 8869.     CrossRef
  • Serum calcium levels independently predict in-hospital mortality in patients with acute myocardial infarction
    A. Shiyovich, Y. Plakht, H. Gilutz
    Nutrition, Metabolism and Cardiovascular Diseases.2018; 28(5): 510.     CrossRef
  • Primary Bone Marrow B-Cell Lymphoma Undetected by Multiple Imaging Modalities That Initially Presented with Hypercalcemia
    Jin Sae Yoo, Juwon Kim, Hyeong Ju Kwon, Jung Soo Lim
    Case Reports in Endocrinology.2018; 2018: 1.     CrossRef
  • Dietary Micronutrient and Mineral Intake in the Mediterranean Healthy Eating, Ageing, and Lifestyle (MEAL) Study
    Dora Castiglione, Armando Platania, Alessandra Conti, Mariagiovanna Falla, Maurizio D’Urso, Marina Marranzano
    Antioxidants.2018; 7(7): 79.     CrossRef
  • Calcium fluxes at the bone/plasma interface: Acute effects of parathyroid hormone (PTH) and targeted deletion of PTH/PTH-related peptide (PTHrP) receptor in the osteocytes
    Christopher Dedic, Tin Shing Hung, Alan M. Shipley, Akira Maeda, Thomas Gardella, Andrew L. Miller, Paola Divieti Pajevic, Joseph G. Kunkel, Alessandro Rubinacci
    Bone.2018; 116: 135.     CrossRef
  • Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism
    Jung Soo Lim, Namki Hong, Sungha Park, Sung Il Park, Young Taik Oh, Min Heui Yu, Pil Yong Lim, Yumie Rhee
    Endocrinology and Metabolism.2018; 33(4): 485.     CrossRef
Close layer
Editorial
Endocrinology and Metabolism Is Indexed in the Emerging Sources Citation Index
Won-Young Lee
Endocrinol Metab. 2017;32(3):350-352.   Published online September 18, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.3.350
  • 4,858 View
  • 44 Download
  • 1 Web of Science
  • 1 Crossref
PDFPubReader   

Citations

Citations to this article as recorded by  
  • Triennial Report ofEndocrinology and Metabolism, 2015 to 2017
    Eun-Jung Rhee, Hey Yeon Jang, Won-Young Lee
    Endocrinology and Metabolism.2018; 33(2): 195.     CrossRef
Close layer
Original Articles
Clinical Study
The Eosinophil Count Tends to Be Negatively Associated with Levels of Serum Glucose in Patients with Adrenal Cushing Syndrome
Younghak Lee, Hyon-Seung Yi, Hae Ri Kim, Kyong Hye Joung, Yea Eun Kang, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Bon Jeong Ku, Minho Shong
Endocrinol Metab. 2017;32(3):353-359.   Published online September 18, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.3.353
  • 9,494 View
  • 52 Download
  • 6 Web of Science
  • 6 Crossref
AbstractAbstract PDFPubReader   
Background

Cushing syndrome is characterized by glucose intolerance, cardiovascular disease, and an enhanced systemic inflammatory response caused by chronic exposure to excess cortisol. Eosinopenia is frequently observed in patients with adrenal Cushing syndrome, but the relationship between the eosinophil count in peripheral blood and indicators of glucose level in patients with adrenal Cushing syndrome has not been determined.

Methods

A retrospective study was undertaken of the clinical and laboratory findings of 40 patients diagnosed with adrenal Cushing syndrome at Chungnam National University Hospital from January 2006 to December 2016. Clinical characteristics, complete blood cell counts with white blood cell differential, measures of their endocrine function, description of imaging studies, and pathologic findings were obtained from their medical records.

Results

Eosinophil composition and count were restored by surgical treatment of all of the patients with adrenal Cushing disease. The eosinophil count was inversely correlated with serum and urine cortisol, glycated hemoglobin, and inflammatory markers in the patients with adrenal Cushing syndrome.

Conclusion

Smaller eosinophil populations in patients with adrenal Cushing syndrome tend to be correlated with higher levels of blood sugar and glycated hemoglobin. This study suggests that peripheral blood eosinophil composition or count may be associated with serum glucose levels in patients with adrenal Cushing syndrome.

Citations

Citations to this article as recorded by  
  • Association between Eosinophil Count and Cortisol Concentrations in Equids Admitted in the Emergency Unit with Abdominal Pain
    María Villalba-Orero, María Dolores Contreras-Aguilar, Jose Joaquín Cerón, Beatriz Fuentes-Romero, Marta Valero-González, María Martín-Cuervo
    Animals.2024; 14(1): 164.     CrossRef
  • Inverse relationship between eosinophil profiles and serum glucose concentration in dogs with naturally occurring hypercortisolism
    Jimin Oh, Dohee Lee, Taesik Yun, Yoonhoi Koo, Yeon Chae, Mhan-Pyo Yang, Byeong-Teck Kang, Hakhyun Kim
    Domestic Animal Endocrinology.2022; 80: 106727.     CrossRef
  • Serum Cortisol and Its Correlation with Leucocyte Profile and Circulating Lipids in Donkeys (Equus asinus)
    Daniela Alberghina, Alessandra Statelli, Vincenzo Monteverde, Irene Vazzana, Giuseppe Cascone, Michele Panzera
    Animals.2022; 12(7): 841.     CrossRef
  • Changes in leukocytes and CRP in different stages of major depression
    Deepti Singh, Paul C. Guest, Henrik Dobrowolny, Veronika Vasilevska, Gabriela Meyer-Lotz, Hans-Gert Bernstein, Katrin Borucki, Alexandra Neyazi, Bernhard Bogerts, Roland Jacobs, Johann Steiner
    Journal of Neuroinflammation.2022;[Epub]     CrossRef
  • HIF1α is a direct regulator of steroidogenesis in the adrenal gland
    Deepika Watts, Johanna Stein, Ana Meneses, Nicole Bechmann, Ales Neuwirth, Denise Kaden, Anja Krüger, Anupam Sinha, Vasileia Ismini Alexaki, Luis Gustavo Perez-Rivas, Stefan Kircher, Antoine Martinez, Marily Theodoropoulou, Graeme Eisenhofer, Mirko Peitz
    Cellular and Molecular Life Sciences.2021; 78(7): 3577.     CrossRef
  • The Immune System in Cushing’s Syndrome
    Valeria Hasenmajer, Emilia Sbardella, Francesca Sciarra, Marianna Minnetti, Andrea M. Isidori, Mary Anna Venneri
    Trends in Endocrinology & Metabolism.2020; 31(9): 655.     CrossRef
Close layer
Clinical Study
Leu72Met and Other Intronic Polymorphisms in the GHRL and GHSR Genes Are Not Associated with Type 2 Diabetes Mellitus, Insulin Resistance, or Serum Ghrelin Levels in a Saudi Population
Faris Elbahi Joatar, Ali Ahmed Al Qarni, Muhalab E. Ali, Abdulaziz Al Masaud, Abdirashid M. Shire, Nagalla Das, Khalid Gumaa, Hayder A. Giha
Endocrinol Metab. 2017;32(3):360-369.   Published online September 18, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.3.360
  • 5,158 View
  • 49 Download
  • 9 Web of Science
  • 13 Crossref
AbstractAbstract PDFPubReader   
Background

Ghrelin (GHRL), a gastric peptide encoded by the GHRL gene, is known to be involved in energy homeostasis via its G protein receptor, encoded by the growth hormone secretagogue receptor (GHSR) gene. Some studies have shown associations between plasma GHRL levels and GHRL single-nucleotide polymorphisms (SNPs), namely the Leu72Met polymorphism (rs696217 TG), with type 2 diabetes mellitus (T2DM) and insulin resistance (IR), while others have not. The controversies in these associations raise the issue of ‘which SNPs in which populations.’ The aim of this study was to investigate whether SNPs in GHRL and/or GHSR genes were associated with T2DM, IR, or plasma GHRL levels among Arab Saudis.

Methods

Blood was collected from 208 Saudi subjects with (n=107) and without (n=101) T2DM. DNA samples from these subjects were analyzed by real-time polymerase chain reaction to genotype five intronic SNPs in the GHRL (rs696217 TG, rs27647 CT, rs2075356 CT, and rs4684677 AT) and GHSR (rs509030 GC) genes. In addition, plasma GHRL levels were measured by a radioimmunoassay.

Results

None of the SNPs were associated with T2DM, IR, or plasma GHRL levels. The frequencies of the alleles, genotypes, and haplotypes of the five SNPs were comparable between the T2DM patients and the non-diabetic subjects. A large number of the GHRL haplotypes indicates the molecular heterogeneity of the preproghrelin gene in this region.

Conclusion

Neither the Leu72Met polymorphism nor the other intronic GHRL and GHSR SNPs were associated with T2DM, IR, or GHRL levels. Further investigations should be carried out to explain the molecular basis of the association of the GHRL peptide with T2DM and IR.

Citations

Citations to this article as recorded by  
  • Exploring the Role of Metabolic Hormones in Amyotrophic Lateral Sclerosis
    Anca Moțățăianu, Ion Bogdan Mănescu, Georgiana Șerban, Laura Bărcuțean, Valentin Ion, Rodica Bălașa, Sebastian Andone
    International Journal of Molecular Sciences.2024; 25(10): 5059.     CrossRef
  • Relationship between single nucleotide polymorphism studies in ghrelin gene with obesity subjects
    May Salem Al-Nbaheen
    Journal of King Saud University - Science.2023; 35(1): 102393.     CrossRef
  • Leu72Met Polymorphism in Ghrelin Gene: A Potential Risk Factor for Hypertension in Type 2 Diabetes Patients
    Monika Buraczynska, Jakub Golacki, Wojciech Zaluska
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 557.     CrossRef
  • Асоціації варіантів гена GHRL із розвитком ожиріння та метаболічних порушень у дітей
    A. Abaturov, A. Nikulina
    CHILD`S HEALTH.2023; 18(4): 255.     CrossRef
  • Effect of the GHRL gene (rs696217) polymorphism on the metabolic disorders in patients with obesity in the Ukrainian population
    Andrii Prodan, Ihor Dzubanovsky, Oleksandr Kamyshnyi, Natalia Melnyk, Stepan Grytsenko, Stanislava Voloshyn
    Endocrine Regulations.2023; 57(1): 173.     CrossRef
  • Impact of gene polymorphism of glutathione S-transferase and ghrelin as a risk factor in Egyptian women with gestational diabetes mellitus
    Mai M. Madkour, Afaf M. El-Said, Abd El-Aziz A. El-Refaey, Abd El-Aziz F. Abd El-Aziz, Fardous F. El-Senduny
    Egyptian Journal of Medical Human Genetics.2022;[Epub]     CrossRef
  • Association of obesity in T2DM with differential polymorphism of ghrelin, growth hormone secretagogue receptor-1 and telomeres maintenance genes
    Hayder A. Giha, Faris E. Joatar, Dhuha M. B. AlDehaini, Zainab H. A. Malalla, Muhalab E. Ali, Ali A. Al Qarni
    Hormone Molecular Biology and Clinical Investigation.2022; 43(3): 297.     CrossRef
  • Investigation of GHRL (rs4684677), FTO (rs8044769) and PGC1Α (rs8192678) polymorphisms in type 2 diabetic Turkish population
    Osman Oğuz, Arezoo Gheybi, Zeliha Doğan, Feray Akbaş, Ümit Zeybek, Arzu Ergen
    Turkish Journal of Biochemistry.2022; 47(5): 564.     CrossRef
  • Grelin ve Grelin Reseptörü Polimorfizmlerinin Tip 2 Diyabetle İlişkisi
    Esma SELÇUK, Uğur ŞAHİN, Didem ÖZKAHRAMAN, Mustafa CALAPOĞLU, Nilüfer ŞAHİN CALAPOĞLU
    Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi.2022; 13(2): 218.     CrossRef
  • Differential Association of Selected Adipocytokines, Adiponectin, Leptin, Resistin, Visfatin and Chemerin, with the Pathogenesis and Progression of Type 2 Diabetes Mellitus (T2DM) in the Asir Region of Saudi Arabia: A Case Control Study
    Mohammad Muzaffar Mir, Rashid Mir, Mushabab Ayed Abdullah Alghamdi, Javed Iqbal Wani, Zia Ul Sabah, Mohammed Jeelani, Vijaya Marakala, Shahzada Khalid Sohail, Mohamed O’haj, Muffarah Hamid Alharthi, Mohannad Mohammad S. Alamri
    Journal of Personalized Medicine.2022; 12(5): 735.     CrossRef
  • Variation analysis of Ghrelin gene in Chinese patients with obesity, having polycystic ovarian syndrome
    Xiaomeng Wang, Fengxiang Qu, Chunlian Wang, Yan Wang, Dan Wang, Min Zhao, Xiangbing Yun, Qingmei Zheng, Lin Xu
    Gynecological Endocrinology.2020; 36(7): 594.     CrossRef
  • The flavonoid baicalin improves glucose metabolism by targeting the PH domain of AKT and activating AKT/GSK3β phosphorylation
    Shengnan Yang, Yuan Zhang, Fukui Shen, Xiaoyao Ma, Man Zhang, Yuanyuan Hou, Gang Bai
    FEBS Letters.2019; 593(2): 175.     CrossRef
  • Ethnicity-Specific Association Between Ghrelin Leu72Met Polymorphism and Type 2 Diabetes Mellitus Susceptibility: An Updated Meta-Analysis
    Rong Huang, Sai Tian, Rongrong Cai, Jie Sun, Yanjue Shen, Shaohua Wang
    Frontiers in Genetics.2018;[Epub]     CrossRef
Close layer
Clinical Study
Excessive Iodine Status among School-Age Children in Korea: A First Report
Young Sik Choi, Soyoung Ock, Sukyoung Kwon, Sang Bong Jung, Kwang-Hyuk Seok, Young Jin Kim, Bu Kyung Kim, Jee-Yeong Jeong
Endocrinol Metab. 2017;32(3):370-374.   Published online September 18, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.3.370
  • 4,690 View
  • 42 Download
  • 4 Web of Science
  • 5 Crossref
AbstractAbstract PDFPubReader   
Background

Korea is considered an iodine sufficient country, and several studies have been conducted regarding iodine status in healthy Korean adults, pregnant women, and preschool children. However, data on iodine status in Korean school-age children are lacking. Therefore, the iodine nutrition status of Korean school-age children was investigated by measuring urine iodine concentration (UIC).

Methods

This cross-sectional study conducted between April and September 2016 comprised 373 school-age children. UIC was determined using a modified microplate method employing ammonium persulfate digestion followed by Sandell-Kolthoff reaction.

Results

The median UIC was 458.2 µg/L. Excessive iodine intake (>300 µg/L) was found in 286 children (76.7%), with extremely high values exceeding 1,000 µg/L in 19.6% of subjects. Insufficient iodine intake (<100 µg/L) was observed in eight children (2.1%). UIC values were not significantly different between sexes.

Conclusion

Korean school-age children showed excessive iodine intake. Therefore, education regarding adequate iodine intake in school-age children is needed.

Citations

Citations to this article as recorded by  
  • Relationship of iodine excess with thyroid function in 6-year-old children living in an iodine-replete area
    Yun Jeong Lee, Sun Wook Cho, Youn-Hee Lim, Bung-Nyun Kim, Johanna Inhyang Kim, Yun-Chul Hong, Young Joo Park, Choong Ho Shin, Young Ah Lee
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Excessive iodine status among school‐aged children in the State of Qatar: Results of the National Iodine Deficiency Disorder Survey
    Mohamed Hamad J. T. Al‐Thani, Salah Abdulla Sh. A. Alyafei, Kholoud Ateeq K. M. Al‐Motawaa, Shamseldin Ali Khalifa, Syed Hassan Bin Usman Shah, Benjamin Vinodson, Sureshbabu Kokku, Amit Mishra
    Public Health Challenges.2023;[Epub]     CrossRef
  • Changing Iodine Status and the Incidence of Thyroid Disease in Mainland China: A Prospective 20-Year Follow-Up Study
    Zhongyan Shan, Yushu Li, Yongze Li, Haoyu Wang, Di Teng, Xiaochun Teng, Wei Chong, Xiaoguang Shi, Jing Li, Jiahui Guo, Zhe Lou, Chenling Fan, Shuangning Ding, Li He, Hua Liu, Elizabeth N. Pearce, Weiping Teng
    Thyroid®.2023; 33(7): 858.     CrossRef
  • Association between urinary sodium levels and iodine status in Korea
    Jonghwa Ahn, Jang Ho Lee, Jiwoo Lee, Ji Yeon Baek, Eyun Song, Hye-Seon Oh, Mijin Kim, Suyeon Park, Min Ji Jeon, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Won Gu Kim
    The Korean Journal of Internal Medicine.2020; 35(2): 392.     CrossRef
  • Effects of Maternal Iodine Status during Pregnancy and Lactation on Maternal Thyroid Function and Offspring Growth and Development: A Prospective Study Protocol for the Ideal Breast Milk Cohort
    Young Ah Lee, Sun Wook Cho, Ho Kyung Sung, Kyungsik Kim, Young Shin Song, Sin Je Moon, Jung Won Oh, Dal Lae Ju, Sooyeon Choi, Sang Hoon Song, Gi Jeong Cheon, Young Joo Park, Choong Ho Shin, Sue K. Park, Jong Kwan Jun, June-Key Chung
    Endocrinology and Metabolism.2018; 33(3): 395.     CrossRef
Close layer
Clinical Study
A Novel Index Using Soluble CD36 Is Associated with the Prevalence of Type 2 Diabetes Mellitus: Comparison Study with Triglyceride-Glucose Index
Ho Jin Kim, Jun Sung Moon, Il Rae Park, Joong Hee Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
Endocrinol Metab. 2017;32(3):375-382.   Published online September 18, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.3.375
  • 5,722 View
  • 48 Download
  • 11 Web of Science
  • 14 Crossref
AbstractAbstract PDFPubReader   
Background

Plasma soluble cluster determinant 36 (sCD36) level is closely related with insulin resistance and atherosclerosis, but little is known whether it could be a surrogate for estimating risk of developing diabetes or not. To address this, we evaluated association between sCD36 index, the product of sCD36 and fasting plasma glucose (FPG), and the prevalence of type 2 diabetes mellitus (T2DM), and then compared with triglyceride-glucose (TyG) index which has been suggested simple index for insulin resistance.

Methods

This was cross-sectional study, and participants were classified as normal glucose tolerance (NGT), prediabetes, and T2DM according to glucose tolerance. The formula of TyG index was ‘ln [FPG (mg/dL)×triglyceride (mg/dL)/2],’ and the sCD36 index was ‘ln [sCD36 (pg/mL)×FPG (mg/dL)/2].’

Results

One hundred and fifty-five subjects (mean age, 55.2 years) were enrolled, and patients with T2DM were 75. Both indexes were significantly increased in prediabetes and T2DM rather than NGT, and sCD36 index was positively correlated with both glycosylated hemoglobin and homeostasis model assessment of insulin resistance (r=0.767 and r=0.453, respectively; P<0.05) and negatively with homeostasis model assessment estimate of β-cell function (r=−0.317). The odds ratio (OR) of sCD36 index for T2DM was 4.39 (95% confidential interval, 1.51 to 12.77) after adjusting age, gender, blood pressure, smoking, alcohol, non-high density lipoprotein cholesterol and high-sensitivity C-reactive protein. However, OR of TyG index did not remained significance after adjustment.

Conclusion

sCD36 index has an independent association with the risk of T2DM, and showed better correlation than TyG index. These results suggest sCD36 index might be useful surrogate marker for the risk of diabetes.

Citations

Citations to this article as recorded by  
  • Enhanced ECCD36 signaling promotes skeletal muscle insulin resistance in female mice
    Austin Dada, Javad Habibi, Huma Naz, Dongqing Chen, Guido Lastra, Brian P. Bostick, Adam Whaley-Connell, Michael A. Hill, James R. Sowers, Guanghong Jia
    American Journal of Physiology-Endocrinology and Metabolism.2024; 327(4): E533.     CrossRef
  • Biomarkers of insulin sensitivity/resistance
    Constantine E Kosmas, Andreas Sourlas, Konstantinos Oikonomakis, Eleni-Angeliki Zoumi, Aikaterini Papadimitriou, Christina E Kostara
    Journal of International Medical Research.2024;[Epub]     CrossRef
  • The triglyceride-glucose index as an indicator of insulin resistance and cardiometabolic risk in Brazilian adolescents
    Miriam Beatrís Reckziegel, Patrik Nepomuceno, Tania Machado, Jane Dagmar Pollo Renner, Hildegard Hedwig Pohl, Carlos Alberto Nogueira-de-Almeida, Elza Daniel de Mello
    Archives of Endocrinology and Metabolism.2023;[Epub]     CrossRef
  • The association of soluble cluster of differentiation 36 with metabolic diseases: A potential biomarker and therapeutic target
    Yun Li, Yaxi Chen, Xiong Z. Ruan
    Pediatric Discovery.2023;[Epub]     CrossRef
  • Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
    Alla Mitrofanova, Sandra Merscher, Alessia Fornoni
    Nature Reviews Nephrology.2023; 19(10): 629.     CrossRef
  • Diabetic cardiac autonomic neuropathy: insulin resistance, lipid profile, and omega-3 polyunsaturated fatty acids
    Martin-Yurii Markevich, Volodymyr Segin, Victoria Serhiyenko, Alexandr Serhiyenko
    InterConf.2023; (35(163)): 213.     CrossRef
  • Insulin resistance estimated by estimated glucose disposal rate predicts outcomes in acute ischemic stroke patients
    Zhengzhao Lu, Yunyun Xiong, Xueyan Feng, Kaixuan Yang, Hongqiu Gu, Xingquan Zhao, Xia Meng, Yongjun Wang
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Usefulness of SPISE Index for Screening and Detection of Early Stages of Insulin Resistance among Chilean Young Adults
    Isabel Pereyra González, Sandra Lopez-Arana
    Annals of Nutrition and Metabolism.2023; 79(4): 372.     CrossRef
  • Oxidative Stress Induced by Lipotoxicity and Renal Hypoxia in Diabetic Kidney Disease and Possible Therapeutic Interventions: Targeting the Lipid Metabolism and Hypoxia
    Seung Yun Chae, Yaeni Kim, Cheol Whee Park
    Antioxidants.2023; 12(12): 2083.     CrossRef
  • Proteomic analysis of epicardial adipose tissue from heart disease patients with concomitant heart failure with preserved ejection fraction
    Shan He, Huagang Zhu, Jianjun Zhang, Xiaopeng Wu, Lei Zhao, Xinchun Yang
    International Journal of Cardiology.2022; 362: 118.     CrossRef
  • DIABETIC CARDIAC AUTONOMIC NEUROPATHY: SIMVASTATIN, INSULIN RESISTANCE AND LIPIDS
    Victoria Serhiyenko, Marta Hotsko, Samir Ajmi, Alexandr Serhiyenko
    InterConf.2022; (18(95)): 531.     CrossRef
  • New insights into renal lipid dysmetabolism in diabetic kidney disease
    Alla Mitrofanova, George Burke, Sandra Merscher, Alessia Fornoni
    World Journal of Diabetes.2021; 12(5): 524.     CrossRef
  • The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond
    Jun Sung Moon, Udayakumar Karunakaran, Elumalai Suma, Seung Min Chung, Kyu Chang Won
    Diabetes & Metabolism Journal.2020; 44(2): 222.     CrossRef
  • The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring
    Kamila Puchałowicz, Monika Ewa Rać
    Cells.2020; 9(8): 1877.     CrossRef
Close layer
Clinical Study
The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus
Yea Eun Kang, Sorim Choung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
Endocrinol Metab. 2017;32(3):383-388.   Published online September 18, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.3.383
  • 4,539 View
  • 54 Download
  • 21 Web of Science
  • 19 Crossref
AbstractAbstract PDFPubReader   
Background

Slit2 is a new secreted protein from adipose tissue that improves glucose hemostasis in mice; however, there is no study about the serum levels and precise role of Slit2 in human. The aim of this study is to explore the serum level of Slit2 in human, and to identify the role of Slit2 in diabetes mellitus (DM).

Methods

The participants of this study consist of 38 subjects with newly diagnosed DM, and 75 healthy subjects as a control group. Serum Slit2 levels were measured using an enzyme-linked immunosorbent assay. Relationship between circulating Slit2 and diabetic related factors was investigated in diabetic group compared with non-diabetic group. Additionally, the correlations between the serum level of Slit2 and diverse metabolic parameters were analyzed.

Results

Circulating Slit2 level was more decreased in diabetic group than in control group, but there was no significant difference statistically. Interestingly, serum levels of Slit2 were significantly negatively correlated to the serum concentrations of fasting glucose (coefficient r=–0.246, P=0.008), the serum concentrations of postprandial glucose (coefficient r=–0.233, P=0.017), and glycosylated hemoglobin (HbA1c; coefficient r=–0.357, P<0.001).

Conclusion

From our study, the first report of circulating Slit2 levels in human, circulating Slit2 level significantly negatively correlated with serum glucose and HbA1c. Our results suggest that the circulating Slit2 may play a role in maintainence of glucose homeostasis in human, even though exact contribution and mechanism are not yet known.

Citations

Citations to this article as recorded by  
  • Brown adipose tissue-derived metabolites and their role in regulating metabolism
    Khanyisani Ziqubu, Phiwayinkosi V. Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
    Metabolism.2024; 150: 155709.     CrossRef
  • An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications
    Zeinab Ghesmati, Mohsen Rashid, Shabnam Fayezi, Frank Gieseler, Effat Alizadeh, Masoud Darabi
    Reviews in Endocrine and Metabolic Disorders.2024; 25(2): 279.     CrossRef
  • The integrated bioinformatic analysis identifies immune microenvironment-related potential biomarkers for patients with gestational diabetes mellitus
    Jie-ling Chen, Hui-fang Dai, Xin-chen Kan, Jie Wu, Hong-Wu Chen
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Adipokines in the Crosstalk between Adipose Tissues and Other Organs: Implications in Cardiometabolic Diseases
    Shaghayegh Hemat Jouy, Sukrutha Mohan, Giorgia Scichilone, Amro Mostafa, Abeer M. Mahmoud
    Biomedicines.2024; 12(9): 2129.     CrossRef
  • Screening and identification of key biomarkers associated with endometriosis using bioinformatics and next-generation sequencing data analysis
    Basavaraj Vastrad, Chanabasayya Vastrad
    Egyptian Journal of Medical Human Genetics.2024;[Epub]     CrossRef
  • Adipokines from white adipose tissue in regulation of whole body energy homeostasis
    Bijayashree Sahu, Naresh C. Bal
    Biochimie.2023; 204: 92.     CrossRef
  • The Role of Slit-2 in Gestational Diabetes Mellitus and Its Effect on Pregnancy Outcome
    Yan Wang, Shihua Zhao, Wei Peng, Ying Chen, Jingwei Chi, Kui Che, Yangang Wang
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • The Heartwarming Effect of Brown Adipose Tissue
    Kelsey M. Pinckard, Kristin I. Stanford
    Molecular Pharmacology.2022; 102(1): 39.     CrossRef
  • New players of the adipose secretome: Therapeutic opportunities and challenges
    Laetitia Coassolo, Niels Banhos Dannieskiold-Samsøe, Meng Zhao, Hobson Allen, Katrin J. Svensson
    Current Opinion in Pharmacology.2022; 67: 102302.     CrossRef
  • Serum CD14 concentration is associated with obesity and insulin resistance in non-diabetic individuals
    Yea Eun Kang, Kyong Hye Joung, Ji Min Kim, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
    Journal of International Medical Research.2022;[Epub]     CrossRef
  • Brown/Beige adipose tissues and the emerging role of their secretory factors in improving metabolic health: The batokines
    Bilal Ahmad, Muhammad Sufyan Vohra, Mansab Ali Saleemi, Christopher J. Serpell, Isabel Lim Fong, Eng Hwa Wong
    Biochimie.2021; 184: 26.     CrossRef
  • Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential
    Bruna B. Brandão, Ankita Poojari, Atefeh Rabiee
    International Journal of Molecular Sciences.2021; 22(11): 5906.     CrossRef
  • Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism
    Camilla Scheele, Christian Wolfrum
    Endocrine Reviews.2020; 41(1): 53.     CrossRef
  • Development of a Cell-Based Assay for the Detection of Neutralizing Antibodies to PF-06730512 Using Homogenous Time-Resolved Fluorescence
    Michael Luong, Ying Wang, Stephen P. Berasi, Janet E. Buhlmann, Hongying Yang, Boris Gorovits
    The AAPS Journal.2020;[Epub]     CrossRef
  • Brown and beige fat: From molecules to physiology and pathophysiology
    Stefania Carobbio, Anne-Claire Guénantin, Isabella Samuelson, Myriam Bahri, Antonio Vidal-Puig
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2019; 1864(1): 37.     CrossRef
  • Serum R-Spondin 1 Is a New Surrogate Marker for Obesity and Insulin Resistance
    Yea Eun Kang, Ji Min Kim, Hyon-Seung Yi, Kyong Hye Joung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
    Diabetes & Metabolism Journal.2019; 43(3): 368.     CrossRef
  • Deletion of Robo4 prevents high‐fat diet‐induced adipose artery and systemic metabolic dysfunction
    Tam T. T. Phuong, Ashley E. Walker, Grant D. Henson, Daniel R. Machin, Dean Y. Li, Anthony J. Donato, Lisa A. Lesniewski
    Microcirculation.2019;[Epub]     CrossRef
  • Adipose Tissue-Derived Signatures for Obesity and Type 2 Diabetes: Adipokines, Batokines and MicroRNAs
    Min-Woo Lee, Mihye Lee, Kyoung-Jin Oh
    Journal of Clinical Medicine.2019; 8(6): 854.     CrossRef
  • The role of brown and beige adipose tissue in glycaemic control
    Katarina Klepac, Anastasia Georgiadi, Matthias Tschöp, Stephan Herzig
    Molecular Aspects of Medicine.2019; 68: 90.     CrossRef
Close layer
Endocrine Research
Effects of Lobeglitazone, a New Thiazolidinedione, on Osteoblastogenesis and Bone Mineral Density in Mice
Kyoung Min Kim, Hyun-Jin Jin, Seo Yeon Lee, Hyo Jin Maeng, Gha Young Lee, Tae Jung Oh, Sung Hee Choi, Hak Chul Jang, Soo Lim
Endocrinol Metab. 2017;32(3):389-395.   Published online September 18, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.3.389
  • 5,728 View
  • 54 Download
  • 11 Web of Science
  • 10 Crossref
AbstractAbstract PDFPubReader   
Background

Bone strength is impaired in patients with type 2 diabetes mellitus despite an increase in bone mineral density (BMD). Thiazolidinedione (TZD), a peroxisome proliferator activated receptor γ agonist, promotes adipogenesis, and suppresses osteoblastogenesis. Therefore, its use is associated with an increased risk of fracture. The aim of this study was to examine the in vitro and in vivo effects of lobeglitazone, a new TZD, on bone.

Methods

MC3T3E1 and C3H10T1/2 cells were cultured in osteogenic medium and exposed to lobeglitazone (0.1 or 1 µM), rosiglitazone (0.4 µM), or pioglitazone (1 µM) for 10 to 14 days. Alkaline phosphatase (ALP) activity, Alizarin red staining, and osteoblast marker gene expression were analyzed. For in vivo experiments, 6-month-old C57BL/6 mice were treated with vehicle, one of two doses of lobeglitazone, rosiglitazone, or pioglitazone. BMD was assessed using a PIXImus2 instrument at the baseline and after 12 weeks of treatment.

Results

As expected, in vitro experiments showed that ALP activity was suppressed and the mRNA expression of osteoblast marker genes RUNX2 (runt-related transcription factor 2) and osteocalcin was significantly attenuated after rosiglitazone treatment. By contrast, lobeglitazone at either dose did not inhibit these variables. Rosiglitazone-treated mice showed significantly accelerated bone loss for the whole bone and femur, but BMD did not differ significantly between the lobeglitazone-treated and vehicle-treated mice.

Conclusion

These findings suggest that lobeglitazone has no detrimental effects on osteoblast biology and might not induce side effects in the skeletal system.

Citations

Citations to this article as recorded by  
  • Efficacy and safety of novel thiazolidinedione lobeglitazone for managing type-2 diabetes a meta-analysis
    Deep Dutta, Saptarshi Bhattacharya, Manoj Kumar, Priyankar K. Datta, Ritin Mohindra, Meha Sharma
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(1): 102697.     CrossRef
  • Efficacy and safety of lobeglitazone, a new Thiazolidinedione, as compared to the standard of care in type 2 diabetes mellitus: A systematic review and meta-analysis
    Shashank R. Joshi, Saibal Das, Suja Xaviar, Shambo Samrat Samajdar, Indranil Saha, Sougata Sarkar, Shatavisa Mukherjee, Santanu Kumar Tripathi, Jyotirmoy Pal, Nandini Chatterjee
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(1): 102703.     CrossRef
  • A Real-World Study of Long-Term Safety and Efficacy of Lobeglitazone in Korean Patients with Type 2 Diabetes Mellitus
    Bo-Yeon Kim, Hyuk-Sang Kwon, Suk Kyeong Kim, Jung-Hyun Noh, Cheol-Young Park, Hyeong-Kyu Park, Kee-Ho Song, Jong Chul Won, Jae Myung Yu, Mi Young Lee, Jae Hyuk Lee, Soo Lim, Sung Wan Chun, In-Kyung Jeong, Choon Hee Chung, Seung Jin Han, Hee-Seok Kim, Ju-Y
    Diabetes & Metabolism Journal.2022; 46(6): 855.     CrossRef
  • Comparative Efficacy of Lobeglitazone Versus Pioglitazone on Albuminuria in Patients with Type 2 Diabetes Mellitus
    Kyung-Soo Kim, Sangmo Hong, Hong-Yup Ahn, Cheol-Young Park
    Diabetes Therapy.2021; 12(1): 171.     CrossRef
  • Lobeglitazone: A Novel Thiazolidinedione for the Management of Type 2 Diabetes Mellitus
    Jaehyun Bae, Taegyun Park, Hyeyoung Kim, Minyoung Lee, Bong-Soo Cha
    Diabetes & Metabolism Journal.2021; 45(3): 326.     CrossRef
  • Effect of lobeglitazone on motor function in rat model of Parkinson’s disease with diabetes co-morbidity
    Kambiz Hassanzadeh, Arman Rahimmi, Mohammad Raman Moloudi, Rita Maccarone, Massimo Corbo, Esmael Izadpanah, Marco Feligioni
    Brain Research Bulletin.2021; 173: 184.     CrossRef
  • Comparison of the Effects of Various Antidiabetic Medication on Bone Mineral Density in Patients with Type 2 Diabetes Mellitus
    Jeonghoon Ha, Yejee Lim, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Ho Song, Seung Hyun Ko, Moo Il Kang, Sung Dae Moon, Ki-Hyun Baek
    Endocrinology and Metabolism.2021; 36(4): 895.     CrossRef
  • Xenogeneic native decellularized matrix carrying PPARγ activator RSG regulating macrophage polarization to promote ligament-to-bone regeneration
    Xue Han, Lijun Liao, Tian Zhu, Yuchan Xu, Fei Bi, Li Xie, Hui Li, Fangjun Huo, Weidong Tian, Weihua Guo
    Materials Science and Engineering: C.2020; 116: 111224.     CrossRef
  • Diabetes pharmacotherapy and effects on the musculoskeletal system
    Evangelia Kalaitzoglou, John L. Fowlkes, Iuliana Popescu, Kathryn M. Thrailkill
    Diabetes/Metabolism Research and Reviews.2019;[Epub]     CrossRef
  • The effects of diabetes therapy on bone: A clinical perspective
    Karim G. Kheniser, Carmen M. Polanco Santos, Sangeeta R. Kashyap
    Journal of Diabetes and its Complications.2018; 32(7): 713.     CrossRef
Close layer
Letter
Letter: Utility of the Visceral Adiposity Index and Hypertriglyceridemic Waist Phenotype for Predicting Incident Hypertension (Endocrinol Metab 2017;32:221-9, Mohsen Janghorbani et al.)
Eun-Jung Rhee
Endocrinol Metab. 2017;32(3):396-397.   Published online September 18, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.3.396
  • 3,682 View
  • 25 Download
  • 2 Web of Science
  • 2 Crossref
PDFPubReader   

Citations

Citations to this article as recorded by  
  • Relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study
    Xiaoping Yu, Dan Wang, Weiming Xiao, Xinlin Shi, Qiang She, Hongguang Sun, Tingyue Qi, Renyan Xu, Guiqing Li, Xinnong Liu, Weijuan Gong, Zhigang Yan, Yanbing Ding, Guotao Lu
    Scientific Reports.2020;[Epub]     CrossRef
  • Response: Utility of the Visceral Adiposity Index and Hypertriglyceridemic Waist Phenotype for Predicting Incident Hypertension (Endocrinol Metab 2017;32:221-9, Mohsen Janghorbani et al.)
    Mohsen Janghorbani
    Endocrinology and Metabolism.2017; 32(4): 485.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism
TOP