Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

OPEN ACCESS
SEARCH
Search

Previous issues

Page Path
HOME > BROWSE ARTICLES > Previous issues
21 Previous issues
Filter
Filter
Article type
Keywords
Authors
Volume 31(3); September 2016
Prev issue Next issue
Review Articles
Obesity and Metabolism
The Diabetes Epidemic in Korea
Junghyun Noh
Endocrinol Metab. 2016;31(3):349-353.   Published online August 26, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.349
  • 4,942 View
  • 42 Download
  • 50 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM

Diabetes is one of the foremost public health issues worldwide that can lead to complications in many organ systems, and has become a significant cause of morbidity and mortality in Korea. According to data from the National Health Insurance Service (NHIS), about 2.7 million Koreans (8.0%) aged 30 years or older had type 2 diabetes mellitus (T2DM) in 2013. The prevalence of T2DM increased with age and rose from 5.6% in 2006 to 8.0% in 2013. Using data based on The Health Screening Service of the NHIS, 25% of Korean adults were reported to have prediabetes in 2013. The prevalence of an impaired fasting glucose tended to increase over time from 21.5% in 2006 to 25.0% in 2013. Even though nationwide health screening has been regularly conducted as a public service, the proportion of undiagnosed cases of diabetes was still reported to be on the higher side in the latest study. Based on the results of these epidemic studies, further actions will be needed to effectively implement lifestyle changes on a social level and increase measures for the early detection of diabetes to stem the tide of the epidemic.

Citations

Citations to this article as recorded by  
  • Nomenclature Dilemma of Metabolic Associated Fatty Liver Disease (MAFLD): Considerable Proportions of MAFLD Are Metabolic Healthy
    Huiyul Park, Eileen L. Yoon, Mimi Kim, Seon Cho, Eun-Hee Nah, Dae Won Jun
    Clinical Gastroenterology and Hepatology.2023; 21(4): 1041.     CrossRef
  • Efficacy of Polydeoxyribonucleotide in Promoting the Healing of Diabetic Wounds in a Murine Model of Streptozotocin-Induced Diabetes: A Pilot Experiment
    Jiyoung Yun, SaeGwang Park, Ha Young Park, Kyung Ah Lee
    International Journal of Molecular Sciences.2023; 24(3): 1932.     CrossRef
  • Influence of Fasting Glucose Level on Gastric Cancer Incidence in a Prospective Cohort Study
    Tao Thi Tran, Jeonghee Lee, Madhawa Gunathilake, Hyunsoon Cho, Jeongseon Kim
    Cancer Epidemiology, Biomarkers & Prevention.2022; 31(1): 254.     CrossRef
  • A Comparative analysis of type 2 diabetes management quality indicators in cancer survivors
    Eun J. Ko, Su J. Lee
    Asia-Pacific Journal of Oncology Nursing.2022; 9(11): 100116.     CrossRef
  • Comparative Effects of Sodium-Glucose Cotransporter 2 Inhibitor and Thiazolidinedione Treatment on Risk of Stroke among Patients with Type 2 Diabetes Mellitus
    Seung Eun Lee, Hyewon Nam, Han Seok Choi, Hoseob Kim, Dae-Sung Kyoung, Kyoung-Ah Kim
    Diabetes & Metabolism Journal.2022; 46(4): 567.     CrossRef
  • Prevalence and diagnosis experience of osteoporosis in postmenopausal women over 50: Focusing on socioeconomic factors
    Min Hyeok Choi, Ji Hee Yang, Jae Seung Seo, Yoon-ji Kim, Suk-Woong Kang, Jose M. Moran
    PLOS ONE.2021; 16(3): e0248020.     CrossRef
  • Effect of Teneligliptin versus Sulfonylurea on Major Adverse Cardiovascular Outcomes in People with Type 2 Diabetes Mellitus: A Real-World Study in Korea
    Da Hea Seo, Kyoung Hwa Ha, So Hun Kim, Dae Jung Kim
    Endocrinology and Metabolism.2021; 36(1): 70.     CrossRef
  • A nationwide study of patients with monoclonal gammopathy of undetermined significance with a 10-year follow-up in South Korea
    Ka-Won Kang, Ji Eun Song, Byung-Hyun Lee, Min Ji Jeon, Eun Sang Yu, Dae Sik Kim, Se Ryeon Lee, Hwa Jung Sung, Chul Won Choi, Yong Park, Byung Soo Kim
    Scientific Reports.2021;[Epub]     CrossRef
  • Fibrosis Burden of Missed and Added Populations According to the New Definition of Metabolic Dysfunction-Associated Fatty Liver
    Huiyul Park, Eileen L. Yoon, Mimi Kim, Jung-Hwan Kim, Seon Cho, Dae Won Jun, Eun-Hee Nah
    Journal of Clinical Medicine.2021; 10(19): 4625.     CrossRef
  • The Effects of Glucose Lowering Agents on the Secondary Prevention of Coronary Artery Disease in Patients with Type 2 Diabetes
    Inha Jung, Hyemi Kwon, Se Eun Park, Kyung-Do Han, Yong-Gyu Park, Eun-Jung Rhee, Won-Young Lee
    Endocrinology and Metabolism.2021; 36(5): 977.     CrossRef
  • Decreased Vagal Activity and Deviation in Sympathetic Activity Precedes Development of Diabetes
    Da Young Lee, Mi Yeon Lee, Jung Hwan Cho, Hyemi Kwon, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Won-Young Lee, Sung-Woo Park, Seungho Ryu, Se Eun Park
    Diabetes Care.2020; 43(6): 1336.     CrossRef
  • Efficacy and safety of ertugliflozin in East/Southeast Asian patients with type 2 diabetes mellitus
    Jie Liu, Shrita Patel, Nilo B. Cater, Larry Wu, Susan Huyck, Steven G. Terra, Anne Hickman, Amanda Darekar, Annpey Pong, Ira Gantz
    Diabetes, Obesity and Metabolism.2020; 22(4): 574.     CrossRef
  • Outcomes for Inappropriate Renal Dose Adjustment of Dipeptidyl Peptidase-4 Inhibitors in Patients With Type 2 Diabetes Mellitus: Population-Based Study
    Sangmo Hong, Kyungdo Han, Cheol-Young Park
    Mayo Clinic Proceedings.2020; 95(1): 101.     CrossRef
  • Longitudinal Study of Diabetic Differences between International Migrants and Natives among the Asian Population
    Heng Piao, Jae Moon Yun, Aesun Shin, Belong Cho
    Biomolecules & Therapeutics.2020; 28(1): 110.     CrossRef
  • Risk of active tuberculosis development in contacts exposed to infectious tuberculosis in congregate settings in Korea
    Shin Young Park, Sunmi Han, Young-Man Kim, Jieun Kim, Sodam Lee, Jiyeon Yang, Un-Na Kim, Mi-sun Park
    Scientific Reports.2020;[Epub]     CrossRef
  • The Combined Impact of Chronic Kidney Disease and Diabetes on the Risk of Colorectal Cancer Depends on Sex: A Nationwide Population-Based Study
    Hyung Jung Oh, Hye Ah Lee, Chang Mo Moon, Dong-Ryeol Ryu
    Yonsei Medical Journal.2020; 61(6): 506.     CrossRef
  • Coffee Consumption, Genetic Polymorphisms, and the Risk of Type 2 Diabetes Mellitus: A Pooled Analysis of Four Prospective Cohort Studies
    An Na Kim, Hyun Jeong Cho, Jiyoung Youn, Taiyue Jin, Moonil Kang, Joohon Sung, Jung Eun Lee
    International Journal of Environmental Research and Public Health.2020; 17(15): 5379.     CrossRef
  • Current findings of kidney biopsy including nephropathy associated with hypertension and diabetes mellitus in Korea
    Kipyo Kim, Sang Ho Lee, Sung Woo Lee, Jung Pyo Lee, Ho Jun Chin
    The Korean Journal of Internal Medicine.2020; 35(5): 1173.     CrossRef
  • A Diabetes-Related Dietary Pattern Is Associated with Incident Diabetes in Obese Men in the Korean Genome Epidemiology Study
    Hye Ah Lee, NaYeong Son, Won Kyung Lee, Hyesook Park
    The Journal of Nutrition.2019; 149(2): 323.     CrossRef
  • Associations of postmenopausal hormone therapy with metabolic syndrome among diabetic and non-diabetic women
    Ji-Eun Kim, Jaesung Choi, JooYong Park, Jong-koo Lee, Aesun Shin, Sang Min Park, Daehee Kang, Ji-Yeob Choi
    Maturitas.2019; 121: 76.     CrossRef
  • The changing epidemiology of herpes zoster over a decade in South Korea, 2006–2015
    Jae-Ki Choi, Sun Hee Park, Sanghyun Park, Sung-Yeon Cho, Hyo-Jin Lee, Si-Hyun Kim, Su-Mi Choi, Dong-Gun Lee, Jung-Hyun Choi, Jin-Hong Yoo
    Vaccine.2019; 37(36): 5153.     CrossRef
  • Prevalence of undiagnosed diabetes and pre-diabetes and its associated risk factors in Vietnam
    Van Dat Nguyen, Quang Mai Vien, Thai Hung Do, Cong Danh Phan, Huu Chau Nguyen, Van Tuyen Nguyen, Dinh Luong Nguyen, Won Seok Sir, Yun Chon
    Journal of Global Health Science.2019;[Epub]     CrossRef
  • Heterogeneous Trajectories of Cognitive Function in Older Adults with Diabetes: Findings from the Korean Longitudinal Study of Aging (KLoSA)
    Chanhee Kim, Min Jung Kim, Chang Gi Park
    Stress.2019; 27(1): 1.     CrossRef
  • The Effect of Coffee Consumption on the Prevalence of Diabetes Mellitus: The 2012–2016 Korea National Health and Nutrition Examination Survey
    Yejee Lim, Youngmi Park, Sun Kyu Choi, Soyeon Ahn, Jung Hun Ohn
    Nutrients.2019; 11(10): 2377.     CrossRef
  • Effects of sodium-glucose cotransporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors on diabetic retinopathy and its progression: A real-world Korean study
    Yoo-Ri Chung, Kyoung Hwa Ha, Kihwang Lee, Dae Jung Kim, Ping-Hsun Wu
    PLOS ONE.2019; 14(10): e0224549.     CrossRef
  • Letter: Projection of Diabetes Prevalence in Korean Adults for the Year 2030 Using Risk Factors Identified from National Data (Diabetes Metab J 2019;43:90–6)
    Bo Kyung Koo
    Diabetes & Metabolism Journal.2019; 43(2): 242.     CrossRef
  • Changes of computed tomography‐based body composition after adrenalectomy in patients with endogenous hypercortisolism
    Namki Hong, Jooyeon Lee, Cheol Ryong Ku, Kichang Han, Cho Rok Lee, Sang Wook Kang, Yumie Rhee
    Clinical Endocrinology.2019; 90(2): 267.     CrossRef
  • Estimating Lifetime Duration of Diabetes by Age and Gender in the Korean Population Using a Markov Model
    Seung Woo Cho, Seon Ha Kim, Young-Eun Kim, Seok-Jun Yoon, Min-Woo Jo
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Hospital-Based Korean Diabetes Prevention Study: A Prospective, Multi-Center, Randomized, Open-Label Controlled Study
    Sang Youl Rhee, Suk Chon, Kyu Jeung Ahn, Jeong-Taek Woo
    Diabetes & Metabolism Journal.2019; 43(1): 49.     CrossRef
  • Medical Big Data Is Not Yet Available: Why We Need Realism Rather than Exaggeration
    Hun-Sung Kim, Dai-Jin Kim, Kun-Ho Yoon
    Endocrinology and Metabolism.2019; 34(4): 349.     CrossRef
  • Implementation of the Chronic Disease Care System and its association with health care costs and continuity of care in Korean adults with type 2 diabetes mellitus
    Woorim Kim, Yoon Soo Choy, Sang Ah Lee, Eun-Cheol Park
    BMC Health Services Research.2018;[Epub]     CrossRef
  • Trends in diabetes prevalence among Korean adults based on Korean National Health and Nutrition Examination Surveys III–VI
    Jae-woo Lee, Hee-Taik Kang, Hyoung-Ji Lim, Byoungjin Park
    Diabetes Research and Clinical Practice.2018; 138: 57.     CrossRef
  • Insulin Resistance and the Risk of Diabetes and Dysglycemia in Korean General Adult Population
    Jong Ha Baek, Hosu Kim, Kyong Young Kim, Jaehoon Jung
    Diabetes & Metabolism Journal.2018; 42(4): 296.     CrossRef
  • Relationship Between Circulating Netrin-1 Concentration, Impaired Fasting Glucose, and Newly Diagnosed Type 2 Diabetes
    Jisook Yim, Gyuri Kim, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Jeong-Ho Kim, Jin Won Cho, Sang-Guk Lee, Yong-ho Lee
    Frontiers in Endocrinology.2018;[Epub]     CrossRef
  • Serum metabolite profile associated with incident type 2 diabetes in Koreans: findings from the Korean Genome and Epidemiology Study
    Soo Jin Yang, So-Young Kwak, Garam Jo, Tae-Jin Song, Min-Jeong Shin
    Scientific Reports.2018;[Epub]     CrossRef
  • Trends in the prevalence of metabolic syndrome and its components in South Korea: Findings from the Korean National Health Insurance Service Database (2009–2013)
    Seung Eun Lee, Kyungdo Han, Yu Mi Kang, Seon-Ok Kim, Yun Kyung Cho, Kyung Soo Ko, Joong-Yeol Park, Ki-Up Lee, Eun Hee Koh, Ying-Mei Feng
    PLOS ONE.2018; 13(3): e0194490.     CrossRef
  • Effect of Change in Total Cholesterol Levels on Cardiovascular Disease Among Young Adults
    Su‐Min Jeong, Seulggie Choi, Kyuwoong Kim, Sung Min Kim, Gyeongsil Lee, Seong Yong Park, Yeon‐Yong Kim, Joung Sik Son, Jae‐Moon Yun, Sang Min Park
    Journal of the American Heart Association.2018;[Epub]     CrossRef
  • Age, sex, and the association of chronic kidney disease with all-cause mortality in Buddhist priests
    Hyo Jin Kim, Yunmi Kim, Sejoong Kim, Ho Jun Chin, Hajeong Lee, Jung Pyo Lee, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Deuk-Young Nah, Sung Joon Shin, Kyung Soo Kim, Jae Yoon Park, Kyung Don Yoo
    Medicine.2018; 97(45): e13099.     CrossRef
  • Association of change in total cholesterol level with mortality: A population-based study
    Su-Min Jeong, Seulggie Choi, Kyuwoong Kim, Sung-Min Kim, Gyeongsil Lee, Joung Sik Son, Jae-Moon Yun, Sang Min Park, Katriina Aalto-Setala
    PLOS ONE.2018; 13(4): e0196030.     CrossRef
  • High hemoglobin levels are associated with decreased risk of diabetic retinopathy in Korean type 2 diabetes
    Min-Kyung Lee, Kyung-Do Han, Jae-Hyuk Lee, Seo-Young Sohn, Jee-Sun Jeong, Mee-Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
    Scientific Reports.2018;[Epub]     CrossRef
  • Impact of systemic inflammation on the relationship between insulin resistance and all-cause and cancer-related mortality
    Da Young Lee, Eun-Jung Rhee, Yoosoo Chang, Chong Il Sohn, Ho-Cheol Shin, Seungho Ryu, Won-Young Lee
    Metabolism.2018; 81: 52.     CrossRef
  • The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus
    Il Young Kim, Sang Soo Kim, Hye Won Lee, Sun Sik Bae, Hong Koo Ha, Eun Soon Jung, Min Young Lee, Miyeun Han, Harin Rhee, Eun Young Seong, Dong Won Lee, Soo Bong Lee, David H. Lovett, Sang Heon Song
    BMC Nephrology.2018;[Epub]     CrossRef
  • The optimal cut-off of blood pressure related to left ventricular diastolic dysfunction and remodeling in Asian diabetic patients
    Ju Young Jung, Sung Keun Park, Jae-Hong Ryoo, Chang-Mo Oh, Jeong Gyu Kang, Kanghee Moon, Keum Ok Lee, Joong-Myung Choi
    Journal of Cardiology.2018; 71(1): 16.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
  • Factors Associated with Smoking Cessation Intention among Current Smokers with Diabetes: Analysis of the 2013 Community Health Survey in Korea
    Young-Hoon Lee, Jum Suk Ko
    Korean Journal of Health Promotion.2017; 17(3): 184.     CrossRef
  • The differences in the incidence of diabetes mellitus and prediabetes according to the type of HMG-CoA reductase inhibitors prescribed in Korean patients
    Tong Min Kim, Hyunah Kim, Yoo Jin Jeong, Sun Jung Baik, So Jung Yang, Seung-Hwan Lee, Jae-Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun-Ho Yoon, Hun-Sung Kim
    Pharmacoepidemiology and Drug Safety.2017; 26(10): 1156.     CrossRef
  • Analysis and comparison of the cost-effectiveness of statins according to the baseline low-density lipoprotein cholesterol level in Korea
    Y. J. Jeong, H. Kim, S. J. Baik, T. M. Kim, S. J. Yang, S.-H. Lee, J.-H. Cho, H. Lee, H. W. Yim, I. Y. Choi, K.-H. Yoon, H.-S. Kim
    Journal of Clinical Pharmacy and Therapeutics.2017; 42(3): 292.     CrossRef
  • Associations of Dietary Antioxidants and Risk of Type 2 Diabetes: Data from the 2007–2012 Korea National Health and Nutrition Examination Survey
    Dan Quansah, Kyungho Ha, Shinyoung Jun, Seong-Ah Kim, Sangah Shin, Gyung-Ah Wie, Hyojee Joung
    Molecules.2017; 22(10): 1664.     CrossRef
  • Accuracy of Capillary Blood Glucose Test When Fasting in Diabetes Patients or General Population: Performance Evaluation of G300 Based on ISO 15197:2013 Standards
    Young-min Jee, Min-hee Seo, Byung-wook Yoo, Sung-ho Hong, Choo-yon Cho, Yong-jin Cho, Jung-eun Oh, Kyung-suk Shin
    Korean Journal of Health Promotion.2017; 17(4): 259.     CrossRef
  • Increased Vascular Disease Mortality Risk in Prediabetic Korean Adults Is Mainly Attributable to Ischemic Stroke
    Nam Hoon Kim, Tae Yeon Kwon, Sungwook Yu, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yousung Park, Sin Gon Kim
    Stroke.2017; 48(4): 840.     CrossRef
Obesity and Metabolism
Insulin Secretory Capacity and Insulin Resistance in Korean Type 2 Diabetes Mellitus Patients
Jong-Dai Kim, Won-Young Lee
Endocrinol Metab. 2016;31(3):354-360.   Published online August 16, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.354
  • 3,682 View
  • 35 Download
  • 14 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM

It is well known that many Korean patients with type 2 diabetes mellitus (T2DM) were non-obese and had decreased insulin secretion in past. However, during the past three decades, lifestyles in Korea have been westernized. As a result, the prevalence of obesity, the main cause of diabetes has increased. Thus, there is still a question as to whether the main pathophysiology of current Korean T2DM is insulin resistance or an insulin secretion defect. Because various anti-diabetes medications having different mechanisms of action are currently used as therapeutics, it is important to understand which of these factors is the main physiology in the development of diabetes in Koreans. In this review, we review changes in obesity prevalence, insulin resistance and insulin secretion defects in Korean T2DM during three decades.

Citations

Citations to this article as recorded by  
  • A double‐blind, Randomized controlled trial on glucose‐lowering EFfects and safety of adding 0.25 or 0.5 mg lobeglitazone in type 2 diabetes patients with INadequate cont
    Soree Ryang, Sang Soo Kim, Ji Cheol Bae, Ji Min Han, Su Kyoung Kwon, Young Il Kim, Il Seong Nam‐Goong, Eun Sook Kim, Mi‐kyung Kim, Chang Won Lee, Soyeon Yoo, Gwanpyo Koh, Min Jeong Kwon, Jeong Hyun Park, In Joo Kim
    Diabetes, Obesity and Metabolism.2022; 24(9): 1800.     CrossRef
  • Waist circumference, body mass index, and colorectal cancer risk according to diabetes status: A Korean nationwide population‐based cohort study
    Dae Bum Kim, Kang‐Moon Lee, Ji Min Lee, Seung‐Hyun Ko, Kyung‐Do Han, Yong Gyu Park
    Journal of Gastroenterology and Hepatology.2021; 36(2): 397.     CrossRef
  • Glucose‐lowering action through targeting islet dysfunction in type 2 diabetes: Focus on dipeptidyl peptidase‐4 inhibition
    Bo Ahrén
    Journal of Diabetes Investigation.2021; 12(7): 1128.     CrossRef
  • The triglyceride–glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance
    Hye Min Park, Hye Sun Lee, Yong-Jae Lee, Jun-Hyuk Lee
    Diabetes Research and Clinical Practice.2021; 180: 109042.     CrossRef
  • Efficacy and Safety of Pioglitazone versus Glimepiride after Metformin and Alogliptin Combination Therapy: A Randomized, Open-Label, Multicenter, Parallel-Controlled Study
    Jeong Mi Kim, Sang Soo Kim, Jong Ho Kim, Mi Kyung Kim, Tae Nyun Kim, Soon Hee Lee, Chang Won Lee, Ja Young Park, Eun Sook Kim, Kwang Jae Lee, Young Sik Choi, Duk Kyu Kim, In Joo Kim
    Diabetes & Metabolism Journal.2020; 44(1): 67.     CrossRef
  • Effect of roux-en Y gastric bypass surgery on patients with type 2 diabetes mellitus
    Ke-Yan Chen, Ying-Li Liu, Jin-Cai Shang, De-Wang Su, Rong-Rong Yao, De-Zhi Ke, Hao Tian
    Medicine.2020; 99(23): e20382.     CrossRef
  • Diabetes, microRNA, and Nutrition in Geriatrics
    Telma Angelina Faraldo Corrêa, Marcelo Macedo Rogero
    Current Geriatrics Reports.2020; 9(4): 229.     CrossRef
  • High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants increased insulin resistance and interacted with coffee and caffeine consumption in middle-aged adults
    J.W. Daily, M. Liu, S. Park
    Nutrition, Metabolism and Cardiovascular Diseases.2019; 29(1): 79.     CrossRef
  • Failure of monotherapy in clinical practice in patients with type 2 diabetes: The Korean National Diabetes Program
    Ja Young Jeon, Soo Jin Lee, Sieun Lee, Soo Jin Kim, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Young Seol Kim, Jeong Taek Woo, Kyu Jeung Ahn, Moonsuk Nam, Sei Hyun Baik, Yongsoo Park, Kwan-Woo Lee
    Journal of Diabetes Investigation.2018; 9(5): 1144.     CrossRef
  • Efficacy and tolerability of novel triple combination therapy in drug-naïve patients with type 2 diabetes from the TRIPLE-AXEL trial: protocol for an open-label randomised controlled trial
    Nam Hoon Kim, Soo Lim, Soo Heon Kwak, Min Kyong Moon, Jun Sung Moon, Yong-ho Lee, Ho Chan Cho, Juneyoung Lee, Sin Gon Kim
    BMJ Open.2018; 8(9): e022448.     CrossRef
  • Impact of systemic inflammation on the relationship between insulin resistance and all-cause and cancer-related mortality
    Da Young Lee, Eun-Jung Rhee, Yoosoo Chang, Chong Il Sohn, Ho-Cheol Shin, Seungho Ryu, Won-Young Lee
    Metabolism.2018; 81: 52.     CrossRef
  • Fimasartan increases glucose‐stimulated insulin secretion in patients with type 2 diabetes and hypertension compared with amlodipine
    Ye Seul Yang, Min Hyuk Lim, Seong Ok Lee, Eun Roh, Chang Ho Ahn, Soo Heon Kwak, Young Min Cho, Sungwan Kim, Andrea Mari, Kyong Soo Park, Hye Seung Jung
    Diabetes, Obesity and Metabolism.2018; 20(7): 1670.     CrossRef
  • Insulin Resistance and Its Association with Metabolic Syndrome in Korean Children
    Jinkyung Cho, Haeryun Hong, Soohyun Park, Shinuk Kim, Hyunsik Kang
    BioMed Research International.2017; 2017: 1.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
Obesity and Metabolism
Novel Molecules Regulating Energy Homeostasis: Physiology and Regulation by Macronutrient Intake and Weight Loss
Anna Gavrieli, Christos S. Mantzoros
Endocrinol Metab. 2016;31(3):361-372.   Published online July 26, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.361
  • 3,304 View
  • 36 Download
  • 13 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM

Excess energy intake, without a compensatory increase of energy expenditure, leads to obesity. Several molecules are involved in energy homeostasis regulation and new ones are being discovered constantly. Appetite regulating hormones such as ghrelin, peptide tyrosine-tyrosine and amylin or incretins such as the gastric inhibitory polypeptide have been studied extensively while other molecules such as fibroblast growth factor 21, chemerin, irisin, secreted frizzle-related protein-4, total bile acids, and heme oxygenase-1 have been linked to energy homeostasis regulation more recently and the specific role of each one of them has not been fully elucidated. This mini review focuses on the above mentioned molecules and discusses them in relation to their regulation by the macronutrient composition of the diet as well as diet-induced weight loss.

Citations

Citations to this article as recorded by  
  • CMKLR1 senses chemerin/resolvin E1 to control adipose thermogenesis and modulate metabolic homeostasis
    Zewei Zhao, Siqi Liu, Bingxiu Qian, Lin Zhou, Jianglin Shi, Junxi Liu, Lin Xu, Zhonghan Yang
    Fundamental Research.2022;[Epub]     CrossRef
  • Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1
    Natalia Porebska, Marta Pozniak, Mateusz Adam Krzyscik, Agata Knapik, Aleksandra Czyrek, Marika Kucinska, Kamil Jastrzebski, Malgorzata Zakrzewska, Jacek Otlewski, Lukasz Opalinski
    International Journal of Biological Macromolecules.2021; 180: 470.     CrossRef
  • Oral Semaglutide, the First Ingestible Glucagon-Like Peptide-1 Receptor Agonist: Could It Be a Magic Bullet for Type 2 Diabetes?
    Hwi Seung Kim, Chang Hee Jung
    International Journal of Molecular Sciences.2021; 22(18): 9936.     CrossRef
  • Serum interleukin 15 in anorexia nervosa: Comparison to normal weight and obese girls
    Wojciech Roczniak, Agata Mikołajczak-Będkowska, Elżbieta Świętochowska, Zofia Ostrowska, Katarzyna Ziora, Sylwia Balcerowicz, Karolina Górska-Flak, Magdalena Milan, Joanna Oświęcimska
    The World Journal of Biological Psychiatry.2020; 21(3): 203.     CrossRef
  • Physiology of energy homeostasis: Models, actors, challenges and the glucoadipostatic loop
    Didier Chapelot, Keyne Charlot
    Metabolism.2019; 92: 11.     CrossRef
  • Correlates of zinc finger BED domain-containing protein 3 and ghrelin in metabolic syndrome patients with and without prediabetes
    Rawan AbuZayed, Nailya Bulatova, Violet Kasabri, Maysa Suyagh, Lana Halaseh, Sundus AlAlawi
    Hormone Molecular Biology and Clinical Investigation.2019;[Epub]     CrossRef
  • Pharmacotherapy of obesity: Available medications and drugs under investigation
    Eleni Pilitsi, Olivia M. Farr, Stergios A. Polyzos, Nikolaos Perakakis, Eric Nolen-Doerr, Aimilia-Eirini Papathanasiou, Christos S. Mantzoros
    Metabolism.2019; 92: 170.     CrossRef
  • Link between chemerin, central obesity, and parameters of the Metabolic Syndrome: findings from a longitudinal study in obese children participating in a lifestyle intervention
    Petra Niklowitz, Juliane Rothermel, Nina Lass, Andre Barth, Thomas Reinehr
    International Journal of Obesity.2018; 42(10): 1743.     CrossRef
  • The relationship between the leptin/ghrelin ratio and meals with various macronutrient contents in men with different nutritional status: a randomized crossover study
    Edyta Adamska-Patruno, Lucyna Ostrowska, Joanna Goscik, Barbara Pietraszewska, Adam Kretowski, Maria Gorska
    Nutrition Journal.2018;[Epub]     CrossRef
  • The Science of Obesity Management: An Endocrine Society Scientific Statement
    George A Bray, William E Heisel, Ashkan Afshin, Michael D Jensen, William H Dietz, Michael Long, Robert F Kushner, Stephen R Daniels, Thomas A Wadden, Adam G Tsai, Frank B Hu, John M Jakicic, Donna H Ryan, Bruce M Wolfe, Thomas H Inge
    Endocrine Reviews.2018; 39(2): 79.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
  • Weight loss technology for people with treated type 2 diabetes: a randomized controlled trial
    Kuat Oshakbayev, Bibazhar Dukenbayeva, Gulnar Togizbayeva, Aigul Durmanova, Meruyert Gazaliyeva, Abdul Sabir, Aliya Issa, Alisher Idrisov
    Nutrition & Metabolism.2017;[Epub]     CrossRef
  • Salivary, gingival crevicular fluid and serum levels of ghrelin and chemerin in patients with periodontitis and overweight
    H. F. R. Jentsch, N. Arnold, V. Richter, J. Deschner, T. Kantyka, S. Eick
    Journal of Periodontal Research.2017; 52(6): 1050.     CrossRef
Thyroid
The Revised 2016 Korean Thyroid Association Guidelines for Thyroid Nodules and Cancers: Differences from the 2015 American Thyroid Association Guidelines
Ka Hee Yi
Endocrinol Metab. 2016;31(3):373-378.   Published online September 26, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.373
  • 5,145 View
  • 126 Download
  • 69 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM

Increased detection of thyroid nodules using high-resolution ultrasonography has resulted in a world-wide increase in the incidence of differentiated thyroid cancer (DTC). Despite the steep increase in its incidence, the age-standardized mortality rate of thyroid cancer has remained stable, which leads toward a trend of more conservative treatment. The latest American Thyroid Association (ATA) guidelines for thyroid nodules and thyroid cancer revised in 2015 suggested that fine needle aspiration biopsy should be performed for thyroid nodules larger than 1 cm and lobectomy might be sufficient for 1 to 4 cm intrathyroidal DTC. In addition, active surveillance instead of immediate surgical treatment was also recommended as a treatment option for papillary thyroid microcarcinoma based on the results of a few observational studies from Japan. The Korean Thyroid Association (KTA) has organized a task force team to develop revised guidelines for thyroid nodules and DTC after an extensive review of articles and intense discussion on whether we should accept the changes in the 2015 ATA guidelines. This paper introduces and discusses the updated major issues and differences in the ATA and the KTA guidelines.

Citations

Citations to this article as recorded by  
  • Prognostic Utility of Tumor Stage versus American Thyroid Association Risk Class in Thyroid Cancer
    Arash Abiri, Jonathan Pang, Karthik R. Prasad, Khodayar Goshtasbi, Edward C. Kuan, William B. Armstrong, Yarah M. Haidar, Tjoson Tjoa
    The Laryngoscope.2023; 133(1): 205.     CrossRef
  • Active surveillance for PTMC warranted for the UK population?
    Pavithran Maniam, Noah Harding, Lucy Li, Richard Adamson, Ashley Hay, Ian Nixon
    Clinical Otolaryngology.2023; 48(1): 88.     CrossRef
  • Biopsy strategies for intermediate and high suspicion thyroid nodules with macrocalcifications
    Sungmok Kim, Jae Ho Shin, Yon Kwon Ihn
    Current Medical Research and Opinion.2023; 39(2): 179.     CrossRef
  • Trends in Diagnosis of Noninvasive Follicular Thyroid Neoplasm With Papillarylike Nuclear Features and Total Thyroidectomies for Patients With Papillary Thyroid Neoplasms
    Lisa Caulley, Antoine Eskander, Weining Yang, Edel Auh, Lydia Cairncross, Nancy L. Cho, Bahar Golbon, Subramania Iyer, Jeffrey C. Liu, Paul J. Lee, Brenessa Lindeman, Charles Meltzer, Nicole Molin, Alessandra Moore, Julia Noel, Halie Nozolino, Jesse Paste
    JAMA Otolaryngology–Head & Neck Surgery.2022; 148(2): 99.     CrossRef
  • What's in a Name? A Cost-Effectiveness Analysis of the Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features' Nomenclature Revision
    Vikas Mehta, Ankita Naraparaju, David Liao, Louise Davies, Bryan R. Haugen, Peter A. Kopp, Susan J. Mandel, Yuri E. Nikiforov, Douglas S. Ross, Jennifer J. Shin, R. Michael Tuttle, Gregory W. Randolph
    Thyroid.2022; 32(4): 421.     CrossRef
  • Clinical management of low-risk papillary thyroid microcarcinoma
    Chie MASAKI, Kiminori SUGINO, Koichi ITO
    Minerva Endocrinology.2022;[Epub]     CrossRef
  • Can Active Surveillance Management be Developed for Patients With Low-Risk Papillary Thyroid Microcarcinoma? A Preliminary Investigation in a Chinese Population
    Wen Liu, Weihan Cao, Zhizhong Dong, Ruochuan Cheng
    Endocrine Practice.2022; 28(4): 391.     CrossRef
  • Assessment of Radiofrequency Ablation for Papillary Microcarcinoma of the Thyroid
    Sam P. J. van Dijk, Hannelore I. Coerts, Sabrina T. G. Gunput, Evert F. S. van Velsen, Marco Medici, Adriaan Moelker, Robin P. Peeters, Cornelis Verhoef, Tessa M. van Ginhoven
    JAMA Otolaryngology–Head & Neck Surgery.2022; 148(4): 317.     CrossRef
  • The Future of Thyroid Nodule Risk Stratification
    Nydia Burgos, Naykky Singh Ospina, Jennifer A. Sipos
    Endocrinology and Metabolism Clinics of North America.2022; 51(2): 305.     CrossRef
  • Complication Rates of Total Thyroidectomy vs Hemithyroidectomy for Treatment of Papillary Thyroid Microcarcinoma
    Vivian Hsiao, Tyler J. Light, Abdullah A. Adil, Michael Tao, Alexander S. Chiu, Mary Hitchcock, Natalia Arroyo, Sara Fernandes-Taylor, David O. Francis
    JAMA Otolaryngology–Head & Neck Surgery.2022; 148(6): 531.     CrossRef
  • Malignancy risk stratification of thyroid nodules smaller than 10 mm with ACR-TIRADS, K-TIRADS, and ATA-2015 guidelines: a prospective study
    Mehrdad Nabahati, Zoleika Moazezi
    Egyptian Journal of Radiology and Nuclear Medicine.2022;[Epub]     CrossRef
  • Thyroglobulin-Based Risk Factor Repositioning for Determining Radioactive Iodine Activity in Patients with Papillary Thyroid Carcinoma: a Multicenter Retrospective Cohort Study
    Subin Jeon, Seong Young Kwon, Sang-Woo Lee, Sang Kyun Bae
    Nuclear Medicine and Molecular Imaging.2022; 56(4): 173.     CrossRef
  • Quality of Life of Survivors of Thyroid Cancer Is Not Inferior to That in Subjects without Cancer: Long-Term after Over 5 Years
    Jeongmin Lee, Youn-Ju Lee, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Min-Hee Kim
    Endocrinology and Metabolism.2022; 37(4): 664.     CrossRef
  • Residual, regrowth, and new growth of radiofrequency ablation for benign thyroid nodules of different volumes: two-year follow-up results
    Meng-Hsiang Chen, Wei-Che Lin, Sheng-Dean Luo, Pi-Ling Chiang, Yueh-Sheng Chen, Wei-Chih Chen, An-Ni Lin, Cheng-Kang Wang, Jung-Hwan Baek, Hsiu-Ling Chen
    International Journal of Hyperthermia.2022; 39(1): 1172.     CrossRef
  • Progression of Low-Risk Papillary Thyroid Microcarcinoma During Active Surveillance: Interim Analysis of a Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma in Korea
    Eun Kyung Lee, Jae Hoon Moon, Yul Hwangbo, Chang Hwan Ryu, Sun Wook Cho, June Young Choi, Eun-Jae Chung, Woo-Jin Jeong, Yuh-Seog Jung, Junsun Ryu, Su-jin Kim, Min Joo Kim, Yeo Koon Kim, Chang Yoon Lee, Ji Ye Lee, Hyeong Won Yu, Jeong Hun Hah, Kyu Eun Lee,
    Thyroid.2022; 32(11): 1328.     CrossRef
  • Recent Changes in the Incidence of Thyroid Cancer in Korea between 2005 and 2018: Analysis of Korean National Data
    Yun Mi Choi, Jiwoo Lee, Mi Kyung Kwak, Min Ji Jeon, Tae Yong Kim, Eun-Gyoung Hong, Won Bae Kim, Won Gu Kim
    Endocrinology and Metabolism.2022; 37(5): 791.     CrossRef
  • Strain Versus 2D Shear-Wave Elastography Parameters—Which Score Better in Predicting Thyroid Cancer?
    Andreea Borlea, Ioan Sporea, Alexandru Popa, Mihnea Derban, Laura Taban, Dana Stoian
    Applied Sciences.2022; 12(21): 11147.     CrossRef
  • Estimating the risk of completion total thyroidectomy using real-world data to guide initial surgical decision-making for patients with clinical low-risk papillary thyroid carcinoma
    Wen Liu, Xiangxiang Zhan, Zhizhong Dong, Yanjun Su, Jianming Zhang, Jun Qian, Yunhai Ma, Chang Diao, Ruochuan Cheng
    Holistic Integrative Oncology.2022;[Epub]     CrossRef
  • Rigorous radiofrequency ablation can completely treat low-risk small papillary thyroid carcinoma without affecting subsequent surgical management
    Xinyang Li, Jie Li, Zhi Qiao, Lin Yan, Jing Xiao, Yingying Li, Mingbo Zhang, Yukun Luo
    European Radiology.2022;[Epub]     CrossRef
  • Whirling technique for thyroid fine needle aspiration biopsy: a preliminary study of effectiveness and safety
    Jae Ho Shin, Seung Wan Han, Hyang Lim Lee, Yon Kwon Ihn
    Ultrasonography.2021; 40(1): 147.     CrossRef
  • Value of dual-phase, contrast-enhanced CT combined with ultrasound for the diagnosis of metastasis to central lymph nodes in patients with papillary thyroid cancer
    Ying Liu, Sheng Li, Cuiju Yan, Caiyun He, Miao Yun, Min Liu, Jianhua Zhou, Longzhong Liu
    Clinical Imaging.2021; 75: 5.     CrossRef
  • Clinical outcomes of T4a papillary thyroid cancer with recurrent laryngeal nerve involvement: a retrospective analysis
    Han-Seul Na, Hyun-Keun Kwon, Sung-Chan Shin, Yong-Il Cheon, Myeonggu Seo, Jin-Choon Lee, Eui-Suk Sung, Minhyung Lee, In-Joo Kim, Bo Hyun Kim, Byung-Joo Lee
    Scientific Reports.2021;[Epub]     CrossRef
  • Protocol for a Korean Multicenter Prospective Cohort Study of Active Surveillance or Surgery (KoMPASS) in Papillary Thyroid Microcarcinoma
    Min Ji Jeon, Yea Eun Kang, Jae Hoon Moon, Dong Jun Lim, Chang Yoon Lee, Yong Sang Lee, Sun Wook Kim, Min-Hee Kim, Bo Hyun Kim, Ho-Cheol Kang, Minho Shong, Sun Wook Cho, Won Bae Kim
    Endocrinology and Metabolism.2021; 36(2): 359.     CrossRef
  • Thyroid nodules in childhood‐onset Hashimoto's thyroiditis: Frequency, risk factors, follow‐up course and genetic alterations of thyroid cancer
    Yun Jeong Lee, Yeon Jin Cho, You Joung Heo, Eun‐Jae Chung, Young Hun Choi, Jong‐Il Kim, Young Joo Park, Choong Ho Shin, Young Ah Lee
    Clinical Endocrinology.2021; 95(4): 638.     CrossRef
  • Clinical implications of age and excellent response to therapy in patients with high‐risk differentiated thyroid carcinoma
    Meihua Jin, Jonghwa Ahn, Yu‐Mi Lee, Tae‐Yon Sung, Dong Eun Song, Tae Yong Kim, Ki‐Wook Chung, Jin‐Sook Ryu, Won Bae Kim, Young Kee Shong, Min Ji Jeon, Won Gu Kim
    Clinical Endocrinology.2021; 95(6): 882.     CrossRef
  • Ecografía clínica de la glándula tiroides y del cuello
    Pepa Bertrán Culla, David Teixidó Gimeno, Pere Guirado Vila
    FMC - Formación Médica Continuada en Atención Primaria.2021; 28(7): 390.     CrossRef
  • Active Surveillance as an Effective Management Option for Low-Risk Papillary Thyroid Microcarcinoma
    Min Ji Jeon, Won Gu Kim, Tae Yong Kim, Young Kee Shong, Won Bae Kim
    Endocrinology and Metabolism.2021; 36(4): 717.     CrossRef
  • Clinical Effects of Microwave Ablation in the Treatment of Low-Risk Papillary Thyroid Microcarcinomas and Related Histopathological Changes
    Chenya Lu, Xingjia Li, Xiaoqiu Chu, Ruiping Li, Jie Li, Jianhua Wang, Yalin Wang, Yang Xu, Guofang Chen, Shuhang Xu, Chao Liu
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Optimization of follow-up in patients with papillary thyroid cancer who show no evidence of disease 9–12 months after treatment
    Fabian Nordell, Ghadir Hallal, Pernilla Asp, Martin Almquist
    BJS Open.2021;[Epub]     CrossRef
  • The most reliable time point for intact parathyroid hormone measurement to predict hypoparathyroidism after total thyroidectomy with central neck dissection to treat papillary thyroid carcinoma: a prospective cohort study
    Jae Won Chang, Ki Wan Park, Seung-Nam Jung, Lihua Liu, Sung Min Kim, Bon Seok Koo
    European Archives of Oto-Rhino-Laryngology.2020; 277(2): 549.     CrossRef
  • Time Trends for Prostate Cancer Incidence from 2003 to 2013 in South Korea: An Age-Period-Cohort Analysis
    Hyun Young Lee, Do Kyoung Kim, Seung Whan Doo, Won Jae Yang, Yun Seob Song, Bora Lee, Jae Heon Kim
    Cancer Research and Treatment.2020; 52(1): 301.     CrossRef
  • Clinical behavior and outcome of papillary T1 thyroid cancers: South Korea vs. Turkey vs. Colombia in a cohort study analyzing oncological outcomes
    Murat Ozdemir, Yong-Sang Lee, Ozer Makay, Juan Pablo Dueñas, Bulent Yazici, Aysegul Akgun, Gokhan Icoz, Mahir Akyildiz, Soo Young Kim, Seok-Mo Kim, Hojin Chang, Hang-Seok Chang, Cheong Soo Park
    Asian Journal of Surgery.2020; 43(8): 795.     CrossRef
  • Radioiodine ablation in thyroid cancer patients: renal function and external radiation dose rate at discharge according to patient preparation
    Yeon-Hee Han, Hwan-Jeong Jeong, Myung-Hee Sohn, Sun Y. Lee, Seok T. Lim
    The Quarterly Journal of Nuclear Medicine and Molecular Imaging.2020;[Epub]     CrossRef
  • Effect of the location and size of thyroid nodules on the diagnostic performance of ultrasound elastography: A retrospective analysis
    Xinxin Xie, Yongqiang Yu
    Clinics.2020; 75: e1720.     CrossRef
  • Fine-Needle Aspiration of Subcentimeter Thyroid Nodules in the Real-World Management


    Chaiho Jeong, Hyunsam Kim, Jeongmin Lee, Jeonghoon Ha, Min-Hee Kim, Moo Il Kang, Dong-Jun Lim
    Cancer Management and Research.2020; Volume 12: 7611.     CrossRef
  • Continuing controversy regarding individualized surgical decision-making for patients with 1–4 cm low-risk differentiated thyroid carcinoma: A systematic review
    Wen Liu, Xuejing Yan, Ruochuan Cheng
    European Journal of Surgical Oncology.2020; 46(12): 2174.     CrossRef
  • Clinical Implication of World Health Organization Classification in Patients with Follicular Thyroid Carcinoma in South Korea: A Multicenter Cohort Study
    Meihua Jin, Eun Sook Kim, Bo Hyun Kim, Hee Kyung Kim, Hyon-Seung Yi, Min Ji Jeon, Tae Yong Kim, Ho-Cheol Kang, Won Bae Kim, Young Kee Shong, Mijin Kim, Won Gu Kim
    Endocrinology and Metabolism.2020; 35(3): 618.     CrossRef
  • Clinical Outcomes of N1b Papillary Thyroid Cancer Patients Treated with Two Different Doses of Radioiodine Ablation Therapy
    Meihua Jin, Jonghwa Ahn, Yu-Mi Lee, Tae-Yon Sung, Won Gu Kim, Tae Yong Kim, Jin-Sook Ryu, Won Bae Kim, Young Kee Shong, Min Ji Jeon
    Endocrinology and Metabolism.2020; 35(3): 602.     CrossRef
  • A Propensity Score-matched Comparison Study of Surgical Outcomes in Patients with Differentiated Thyroid Cancer After Robotic Versus Open Total Thyroidectomy
    Dong Sik Bae, Do Hoon Koo
    World Journal of Surgery.2019; 43(2): 540.     CrossRef
  • Diagnostic value of cytology, thyroglobulin, and combination of them in fine-needle aspiration of metastatic lymph nodes in patients with differentiated thyroid cancer
    Yixin Xu, Dapeng Wu, Wenting Wu, Jian Jiang, Cheng Xi, Nianyuan Ye, Yibo Wang, Xuezhong Xu
    Medicine.2019; 98(45): e17859.     CrossRef
  • Investigation of blood groups in benign thyroid diseases in Turkey
    Murat Dağdeviren, İhsan Ateş, Burak Furkan Demir, Emine Ergün, Canan Yıldız, Mustafa Altay
    Endocrine Journal.2019; 66(11): 1001.     CrossRef
  • Tumor Volume Doubling Time in Active Surveillance of Papillary Thyroid Carcinoma
    Hye-Seon Oh, Hyemi Kwon, Eyun Song, Min Ji Jeon, Tae Yong Kim, Jeong Hyun Lee, Won Bae Kim, Young Kee Shong, Ki-Wook Chung, Jung Hwan Baek, Won Gu Kim
    Thyroid.2019; 29(5): 642.     CrossRef
  • Tumor doubling time predicts response to sorafenib in radioactive iodine-refractory differentiated thyroid cancer
    Min Joo Kim, Seok-Mo Kim, Eun Kyung Lee, Yul Hwangbo, You Jin Lee, Sun Wook Cho, Do Joon Park, Yumi Lee, Young Joo Park
    Endocrine Journal.2019; 66(7): 597.     CrossRef
  • Total thyroidectomy's association with survival in papillary thyroid cancers and the high proportion of total thyroidectomy in low-risk patients: Analysis of Korean nationwide data
    Hyun-Soo Zhang, Eun-Kyung Lee, Yuh-Seog Jung, Byung-Ho Nam, Kyu-Won Jung, Hyun-Joo Kong, Young-Joo Won, Boyoung Park
    Surgery.2019; 165(3): 629.     CrossRef
  • Individualized Follow-Up Strategy for Patients with an Indeterminate Response to Initial Therapy for Papillary Thyroid Carcinoma
    Hye-Seon Oh, Jong Hwa Ahn, Eyun Song, Ji Min Han, Won Gu Kim, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Min Ji Jeon
    Thyroid.2019; 29(2): 209.     CrossRef
  • Differentiated Thyroid Cancer and Radioactive Iodine: Past, Present and Future
    Jaetae Lee, Il Jo
    International Journal of Thyroidology.2019; 12(2): 71.     CrossRef
  • Diagnostic performance of HMGA2 gene expression for differentiation of malignant thyroid nodules: A systematic review and meta-analysis
    Bo Hyun Kim, Seong Jang Kim, Mijin Kim, Sang-Woo Lee, Shin Young Jeong, Kyoungjune Pak, Keunyoung Kim, In Joo Kim
    Clinical Endocrinology.2018; 89(6): 856.     CrossRef
  • Ultrasound risk evaluation of thyroid nodules that are “unspecified” in the 2015 American Thyroid Association management guidelines
    Luying Gao, Xuehua Xi, Juanjuan Wang, Xiao Yang, Ying Wang, Shenling Zhu, Xingjian Lai, Xiaoyan Zhang, Ruina Zhao, Bo Zhang
    Medicine.2018; 97(52): e13914.     CrossRef
  • Refining the eighth edition AJCC TNM classification and prognostic groups for papillary thyroid cancer with lateral nodal metastasis
    Hye In Kim, Kyunga Kim, So Young Park, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim, Young Lyun Oh, Soo Yeon Hahn, Jung Hee Shin, Hyeon Seon Ahn, Sun Wook Kim, Tae Hyuk Kim, Jae Hoon Chung
    Oral Oncology.2018; 78: 80.     CrossRef
  • Thyroid cancer surgery guidelines in an era of de-escalation
    K.J. Kovatch, C.W. Hoban, A.G. Shuman
    European Journal of Surgical Oncology.2018; 44(3): 297.     CrossRef
  • Changes in Serum Thyroglobulin Levels After Lobectomy in Patients with Low-Risk Papillary Thyroid Cancer
    Suyeon Park, Min Ji Jeon, Hye-Seon Oh, Yu-Mi Lee, Tae-Yon Sung, Minkyu Han, Ji Min Han, Tae Yong Kim, Ki-Wook Chung, Won Bae Kim, Young Kee Shong, Won Gu Kim
    Thyroid.2018; 28(8): 997.     CrossRef
  • Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro)
    Jae Hoon Moon, Ji-hoon Kim, Eun Kyung Lee, Kyu Eun Lee, Sung Hye Kong, Yeo Koon Kim, Woo-jin Jung, Chang Yoon Lee, Roh-Eul Yoo, Yul Hwangbo, Young Shin Song, Min Joo Kim, Sun Wook Cho, Su-jin Kim, Eun Jae Jung, June Young Choi, Chang Hwan Ryu, You Jin Lee
    Endocrinology and Metabolism.2018; 33(2): 278.     CrossRef
  • Low-Dose Radioactive Iodine Ablation Is Sufficient in Patients With Small Papillary Thyroid Cancer Having Minor Extrathyroidal Extension and Central Lymph Node Metastasis (T3 N1a): Reply
    Minjung Seo, Yon Seon Kim, Jong Cheol Lee, Myung Woul Han, Eun Sook Kim, Kyung Bin Kim, Seol Hoon Park
    Clinical Nuclear Medicine.2018; 43(8): 635.     CrossRef
  • Diagnosis and treatment of low-risk papillary thyroid microcarcinoma
    Jae Hoon Moon, Young Joo Park
    Journal of the Korean Medical Association.2018; 61(4): 232.     CrossRef
  • Efficacy of a Home-Based Exercise Program After Thyroidectomy for Thyroid Cancer Patients
    Kyunghee Kim, Mee Ock Gu, Jung Hwa Jung, Jong Ryeal Hahm, Soo Kyoung Kim, Jin Hyun Kim, Seung Hoon Woo
    Thyroid.2018; 28(2): 236.     CrossRef
  • Genome-Wide Association Study Reveals Distinct Genetic Susceptibility of Thyroid Nodules From Thyroid Cancer
    Yul Hwangbo, Eun Kyung Lee, Ho-Young Son, Sun-Wha Im, Soo-Jung Kwak, Ji Won Yoon, Min Joo Kim, Jeongseon Kim, Hoon Sung Choi, Chang Hwan Ryu, You Jin Lee, Jong-Il Kim, Nam H Cho, Young Joo Park
    The Journal of Clinical Endocrinology & Metabolism.2018; 103(12): 4384.     CrossRef
  • Active Surveillance of Low-Risk Papillary Thyroid Microcarcinoma: A Multi-Center Cohort Study in Korea
    Hye-Seon Oh, Jeonghoon Ha, Hye In Kim, Tae Hyuk Kim, Won Gu Kim, Dong-Jun Lim, Tae Yong Kim, Sun Wook Kim, Won Bae Kim, Young Kee Shong, Jae Hoon Chung, Jung Hwan Baek
    Thyroid.2018; 28(12): 1587.     CrossRef
  • Ultrasound criteria for risk stratification of thyroid nodules in the previously iodine deficient area of Austria - a single centre, retrospective analysis
    Christina Tugendsam, Veronika Petz, Wolfgang Buchinger, Brigitta Schmoll-Hauer, Iris Pia Schenk, Karin Rudolph, Michael Krebs, Georg Zettinig
    Thyroid Research.2018;[Epub]     CrossRef
  • Practical Initial Risk Stratification Based on Lymph Node Metastases in Pediatric and Adolescent Differentiated Thyroid Cancer
    Min Ji Jeon, Young Nam Kim, Tae-Yong Sung, Suck Joon Hong, Yoon Young Cho, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Sun Wook Kim, Jae Hoon Chung, Tae Hyuk Kim, Won Gu Kim
    Thyroid.2018; 28(2): 193.     CrossRef
  • Current Radiological Approach in Thyroid Nodules
    Duzgun Yildirim, Deniz Alis, Sabri Sirolu, Cesur Samanci, Fethi Emre Ustabasioglu, Bulent Colakoglu
    Journal of Cancer Therapy.2017; 08(05): 423.     CrossRef
  • A new paradigm in low-risk papillary microcarcinoma: active surveillance
    Alex González Bóssolo, Michelle Mangual Garcia, Paula Jeffs González, Miosotis Garcia, Guillermo Villarmarzo, Jose Hernán Martinez
    Endocrinology, Diabetes & Metabolism Case Reports.2017;[Epub]     CrossRef
  • Serial Neck Ultrasonographic Evaluation of Changes in Papillary Thyroid Carcinoma During Pregnancy
    Hye-Seon Oh, Won Gu Kim, Suyeon Park, Mijin Kim, Hyemi Kwon, Min Ji Jeon, Jeong Hyun Lee, Jung Hwan Baek, Dong Eun Song, Tae Yong Kim, Young Kee Shong, Won Bae Kim
    Thyroid.2017; 27(6): 773.     CrossRef
  • Restratification of survival prognosis of N1b papillary thyroid cancer by lateral lymph node ratio and largest lymph node size
    Hye In Kim, Tae Hyuk Kim, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim, Young Lyun Oh, Soo Yeon Hahn, Jung Hee Shin, Hye Won Jang, Young Nam Kim, Hosu Kim, Hyeon Seon Ahn, Kyunga Kim, Sun Wook Kim, Jae Hoon Chung
    Cancer Medicine.2017; 6(10): 2244.     CrossRef
  • Comparison on Fine Needle Aspiration Cytology (FNAC) and Thyroid Ultrasonography in Management of Thyroid Nodules
    Sandini A Gunaratne
    International Clinical Pathology Journal.2017;[Epub]     CrossRef
  • Current Practices of Thyroid Fine-Needle Aspiration in Asia: A Missing Voice
    Andrey Bychkov, Kennichi Kakudo, SoonWon Hong
    Journal of Pathology and Translational Medicine.2017; 51(6): 517.     CrossRef
  • Clinical outcomes after delayed thyroid surgery in patients with papillary thyroid microcarcinoma
    Min Ji Jeon, Won Gu Kim, Hyemi Kwon, Mijin Kim, Suyeon Park, Hye-Seon Oh, Minkyu Han, Tae-Yon Sung, Ki-Wook Chung, Suck Joon Hong, Tae Yong Kim, Young Kee Shong, Won Bae Kim
    European Journal of Endocrinology.2017; 177(1): 25.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
  • The Impact of Thyroid Nodule Size and Fine-Needle Aspiration Biopsy Result on the Risk of Malignancy in the Patients Who Underwent Thyroidectomy
    Hwibin Im, Yu-Young Park, Jae-Gu Cho, Seung-Kuk Baek, Soon-Young Kwon, Kwang-Yoon Jung, Jeong-Soo Woo
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2017; 60(6): 308.     CrossRef
  • Active Surveillance of Papillary Thyroid Microcarcinoma: A Mini-Review from Korea
    Tae Yong Kim, Young Kee Shong
    Endocrinology and Metabolism.2017; 32(4): 399.     CrossRef
Thyroid
Recent Advances in Autoimmune Thyroid Diseases
Won Sang Yoo, Hyun Kyung Chung
Endocrinol Metab. 2016;31(3):379-385.   Published online August 26, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.379
  • 4,728 View
  • 91 Download
  • 26 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM

Autoimmune thyroid disease (AITD) includes hyperthyroid Graves disease, hypothyroid autoimmune thyroiditis, and subtle subclinical thyroid dysfunctions. AITD is caused by interactions between genetic and environmental predisposing factors and results in autoimmune deterioration. Data on polymorphisms in the AITD susceptibility genes, related environmental factors, and dysregulation of autoimmune processes have accumulated over time. Over the last decade, there has been progress in the clinical field of AITD with respect to the available diagnostic and therapeutic methods as well as clinical consensus. The updated clinical guidelines allow practitioners to identify the most reasonable and current approaches for proper management. In this review, we focus on recent advances in understanding the genetic and environmental pathogenic mechanisms underlying AITD and introduce the updated set of clinical guidelines for AITD management. We also discuss other aspects of the disease such as management of subclinical thyroid dysfunction, use of levothyroxine plus levotriiodothyronine in the treatment of autoimmune hypothyroidism, risk assessment of long-standing antithyroid drug therapy in recurrent Graves' hyperthyroidism, and future research needs.

Citations

Citations to this article as recorded by  
  • Salenio: clinical study design
    Domenico Parmeggiani, Paola Bassi, Maddalena Claudia Donnarumma, Chiara Colonnese, Vincenzo Ieluzzi, Laura Pacca, Chiara Agresti, Massimo Agresti
    Endocrinology&Metabolism International Journal.2023; 11(1): 1.     CrossRef
  • Autoimmune thyroiditis in different age groups and subjects of reproductive age in Adzhariya population
    N. G. Tchelidze, S. Z. Glonti, D. Sh. Baratashvili, N. O. Kedelidze, J. Yu. Ungiadze, I. I. Nakashidze
    Obstetrics, Gynecology and Reproduction.2022; 16(1): 8.     CrossRef
  • Alterations and Mechanism of Gut Microbiota in Graves’ Disease and Hashimoto’s Thyroiditis
    Hong Zhao, Lijie Yuan, Dongli Zhu, Banghao Sun, Juan Du, Jingyuan Wang
    Polish Journal of Microbiology.2022; 71(2): 173.     CrossRef
  • The association of six autoimmune bullous diseases with thyroid disorders: a population‐based study
    K. Kridin, F. Hübner, R. Linder, E. Schmidt
    Journal of the European Academy of Dermatology and Venereology.2022; 36(10): 1826.     CrossRef
  • Investigation of comorbid autoimmune diseases in women with autoimmune bullous diseases: An interplay of autoimmunity and practical implications
    Meropi Karakioulaki, Dedee F. Murrell, Aikaterini Kyriakou, Aikaterini Patsatsi
    International Journal of Women’s Dermatology.2022; 8(3): e053.     CrossRef
  • Best Achievements in Translational and Basic Thyroidology in 2020
    Sun Wook Cho, Young Joo Park
    Endocrinology and Metabolism.2021; 36(1): 36.     CrossRef
  • Incidence and Clinical Implications of Autoimmune Thyroiditis in the Development of Acne in Young Patients
    Laura Endres, Delia Mirela Tit, Simona Bungau, Nicoleta Anamaria Pascalau, Laura Maghiar Țodan, Erika Bimbo-Szuhai, Gabriela Mariana Iancu, Nicoleta Negrut
    Diagnostics.2021; 11(5): 794.     CrossRef
  • Attaining Euthyroidism - Seal the Loopholes
    Payel Biswas, Subhankar Chatterjee
    International Journal of Thyroidology.2021; 14(1): 69.     CrossRef
  • Cardiac Autonomic Modulation and Anti-Thyroid Peroxidase (TPO) Antibodies in Subclinical Hypothyroidism – Does Any Correlation Exist?
    Manisha Mavai, Dr Bharti Bhandari , Anish Singhal, Sandeep K Mathur
    Cureus.2021;[Epub]     CrossRef
  • Chronic urticaria and thyroid pathology
    Sandra Nora Gonzalez-Diaz, Mario Sanchez-Borges, Diana Maria Rangel-Gonzalez, Rosa Ivett Guzman-Avilan, Jose Ignacio Canseco-Villarreal, Alfredo Arias-Cruz
    World Allergy Organization Journal.2020; 13(3): 100101.     CrossRef
  • Genome-Wide Analysis Identifies Two Susceptibility Loci for Positive Thyroid Peroxidase and Thyroglobulin Antibodies
    Antonela Matana, Thibaud Boutin, Vesela Torlak, Dubravka Brdar, Ivana Gunjača, Ivana Kolčić, Vesna Boraska Perica, Ante Punda, Ozren Polašek, Maja Barbalić, Caroline Hayward, Tatijana Zemunik
    The Journal of Clinical Endocrinology & Metabolism.2020; 105(3): 944.     CrossRef
  • Iodine and bromine in fish consumed by indigenous peoples of the Russian Arctic
    Nikita Sobolev, Andrey Aksenov, Tatiana Sorokina, Valery Chashchin, Dag G. Ellingsen, Evert Nieboer, Yulia Varakina, Elena Plakhina, Alexandra Onuchina, Magny Skinlo Thomassen, Yngvar Thomassen
    Scientific Reports.2020;[Epub]     CrossRef
  • Significance of arsenic and lead in Hashimoto's thyroiditis demonstrated on thyroid tissue, blood, and urine samples
    Aleksandar Stojsavljević, Branislav Rovčanin, Jovana Jagodić, Danijela Drašković Radojković, Ivan Paunović, Marija Gavrović-Jankulović, Dragan Manojlović
    Environmental Research.2020; 186: 109538.     CrossRef
  • Prognostic Value of Caspase-1, Interleukin-1β, Tumor Necrosis Factor-α and Interleukin-18 Activity in Patients with Gastroesophageal Reflux Disease and Autoimmune Thyroiditis
    T. M. Pasiieshvili, O. M. Kovaloyva, L. M. Pasiieshvili , N. M. Zhelezniakova
    Ukraïnsʹkij žurnal medicini, bìologìï ta sportu.2020; 5(4): 202.     CrossRef
  • A historical excursus of diagnostic methods for Hashimoto thyroiditis and Graves' disease
    Maria Trovato
    Gazzetta Medica Italiana Archivio per le Scienze Mediche.2020;[Epub]     CrossRef
  • Hydatid cyst of the thyroid gland with tracheal fistula: A case report and review of the literature
    Tiemin Jiang, Qiang Guo, Bo Ran, Ruiqing Zhang, Tuerganaili Aji, Yingmei Shao
    Experimental and Therapeutic Medicine.2019;[Epub]     CrossRef
  • Thyroid diseases and skin autoimmunity
    Enke Baldini, Teresa Odorisio, Chiara Tuccilli, Severino Persechino, Salvatore Sorrenti, Antonio Catania, Daniele Pironi, Giovanni Carbotta, Laura Giacomelli, Stefano Arcieri, Massimo Vergine, Massimo Monti, Salvatore Ulisse
    Reviews in Endocrine and Metabolic Disorders.2018; 19(4): 311.     CrossRef
  • Does severe vitamin D deficiency impact obstetric outcomes in pregnant women with thyroid autoimmunity?
    Halenur Bozdag, Esra Akdeniz
    The Journal of Maternal-Fetal & Neonatal Medicine.2018; : 1.     CrossRef
  • Constitutive Changes in Circulating Follicular Helper T Cells and Their Subsets in Patients with Graves’ Disease
    Yan Liu, Xinwang Yuan, Xiaofang Li, Dawei Cui, Jue Xie
    Journal of Immunology Research.2018; 2018: 1.     CrossRef
  • The value of preoperative antithyroidperoxidase antibody as a novel predictor of recurrence in papillary thyroid carcinoma
    Eyun Song, Hye‐Seon Oh, Min Ji Jeon, Ki Wook Chung, Suck Joon Hong, Jin Sook Ryu, Jung Hwan Baek, Jeong Hyun Lee, Won Gu Kim, Won Bae Kim, Young Kee Shong, Tae Yong Kim
    International Journal of Cancer.2018;[Epub]     CrossRef
  • Comorbidity of autoimmune thyroid disorders and psychiatric disorders during the postpartum period: a Danish nationwide register-based cohort study
    V. Bergink, V. J. M. Pop, P. R. Nielsen, E. Agerbo, T. Munk-Olsen, X. Liu
    Psychological Medicine.2018; 48(8): 1291.     CrossRef
  • Spontaneous conversion from Graves’ disease to Hashimoto’s thyroiditis: a case report
    Muharrem Bayrak, Kenan Çadırcı, Emine Kartal Baykan, Ünsal Aydın, Ayşe Çarlıoğlu
    Ortadoğu Tıp Dergisi.2018; 10(1): 81.     CrossRef
  • Role of T Follicular Helper (Tfh) Cells Plasticity in Autoimmune Thyroiditis among Hepatitis C Virus Infection
    Helal F Hetta
    Gastroenterology & Hepatology: Open Access.2017;[Epub]     CrossRef
  • Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease
    Rong-hua Song, Qian Li, Wen Wang, Qiu-ming Yao, Xiao-qing Shao, Jin-an Zhang
    International Journal of Endocrinology.2017; 2017: 1.     CrossRef
  • Thyroid Involvement in Hepatitis C Virus-Infected Patients with/without Mixed Cryoglobulinemia
    Clodoveo Ferri, Michele Colaci, Poupak Fallahi, Silvia Martina Ferrari, Alessandro Antonelli, Dilia Giuggioli
    Frontiers in Endocrinology.2017;[Epub]     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
Thyroid
Update on the Management of Thyroid Disease during Pregnancy
Chang Hoon Yim
Endocrinol Metab. 2016;31(3):386-391.   Published online August 16, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.386
  • 3,066 View
  • 52 Download
  • 11 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM

Thyroid dysfunction during pregnancy can result in serious complications for both the mother and infant; however, these complications can be prevented by optimal treatment of maternal overt thyroid dysfunction. Although several studies have demonstrated that maternal subclinical hypothyroidism is associated with obstetric complications and neurocognitive impairments in offspring, there is limited evidence that levothyroxine treatment can improve these complications. Therefore, most professional societies do not recommend universal screening for thyroid dysfunction during pregnancy, and instead recommend a case-finding approach in which only high-risk women are tested. However, recent studies have estimated that targeted thyroid function testing misses approximately 30% to 55% of hypothyroidism cases in pregnant women, and some associations and researchers have recommended universal screening of pregnant women to facilitate the early detection and treatment of overt hypothyroidism. This review summarizes recent data on thyroid function test changes, thyroid functional disorder management, and thyroid screening during pregnancy.

Citations

Citations to this article as recorded by  
  • Enfermedades tiroideas y embarazo en una unidad de cuidados intensivos. Experiencia 2014-2019
    J.G. Vázquez-Rodríguez, A.C. Andrade-Rodríguez
    Clínica e Investigación en Ginecología y Obstetricia.2021; 48(3): 100662.     CrossRef
  • Decreased Expression of Ileal Thyroid Hormone Transporters in a Hypothyroid Patient: A Case Report
    Chae Won Chung, Eun Young Mo, Gyung Seo Jung, Yoo Hyung Kim, Sun Wook Cho, Do Joon Park, Jeong Mo Bae, Young Joo Park
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Tiroidectomía en paciente embarazada con enfermedad de Graves sin respuesta a tratamiento médico: reporte de caso
    Elly Morros González, Leonardo Javier Rojas Melo, Viviana Cruz Ramírez, Angélica Imitola
    Universitas Médica.2020;[Epub]     CrossRef
  • Thyroid disorders in subfertility and early pregnancy
    Samantha Anandappa, Mamta Joshi, Lukasz Polanski, Paul V. Carroll
    Therapeutic Advances in Endocrinology and Metabolism.2020; 11: 204201882094585.     CrossRef
  • Addressing thyroid dysfunction in pregnancy
    Teodora Onciu, Remus Şipoş
    Medic.ro.2020; 3(135): 48.     CrossRef
  • Antenatal/early postnatal hypothyroidism increases the contribution of Rho-kinase to contractile responses of mesenteric and skeletal muscle arteries in adult rats
    Dina K. Gaynullina, Svetlana I. Sofronova, Anastasia A. Shvetsova, Ekaterina K. Selivanova, Anna P. Sharova, Andrey A. Martyanov, Olga S. Tarasova
    Pediatric Research.2018; 84(1): 112.     CrossRef
  • Voluntary exercise training restores anticontractile effect of NO in coronary arteries of adult rats with antenatal/early postnatal hypothyroidism
    D.K. Gaynullina, A.A. Borzykh, S.I. Sofronova, E.K. Selivanova, A.A. Shvetsova, A.A. Martyanov, I.V. Kuzmin, O.S. Tarasova
    Nitric Oxide.2018; 74: 10.     CrossRef
  • Impact of positive thyroid autoimmunity on pregnant women with subclinical hypothyroidism
    Cristina López-Tinoco, Amparo Rodríguez-Mengual, Almudena Lara-Barea, Julia Barcala, Laura Larrán, Ana Saez-Benito, Manuel Aguilar-Diosdado
    Endocrinología, Diabetes y Nutrición (English ed.).2018; 65(3): 150.     CrossRef
  • Impacto de la autoinmunidad antitiroidea positiva en gestantes con hipotiroidismo subclínico
    Cristina López-Tinoco, Amparo Rodríguez-Mengual, Almudena Lara-Barea, Julia Barcala, Laura Larrán, Ana Saez-Benito, Manuel Aguilar-Diosdado
    Endocrinología, Diabetes y Nutrición.2018; 65(3): 150.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
  • Maternal hypothyroidism: An overview of current experimental models
    Mahboubeh Ghanbari, Asghar Ghasemi
    Life Sciences.2017; 187: 1.     CrossRef
Thyroid
Recent Updates on the Management of Medullary Thyroid Carcinoma
Bo Hyun Kim, In Joo Kim
Endocrinol Metab. 2016;31(3):392-399.   Published online August 26, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.392
  • 3,863 View
  • 52 Download
  • 25 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor derived from the thyroid C cells producing calcitonin. MTC accounts for 0.6% of all thyroid cancers and incidence of MTC increased steadily between 1997 and 2011 in Korea. It occurs either sporadically or in a hereditary form based on germline rearranged during transfection (RET) mutations. MTC can be cured only by complete resection of the thyroid tumor and any loco-regional metastases. The most appropriate treatment is still less clear in patients with residual or recurrent disease after initial surgery or those with distant metastases because most patients even with metastatic disease have indolent courses with slow progression for several years and MTC is not responsive to either radioactive iodine therapy or thyroid-stimulating hormone suppression. Recently, two tyrosine kinase inhibitors (TKIs), vandetanib and cabozantinib, are approved for use in patients with advanced, metastatic or progressive MTC. In this review, we summarize the current approach according to revised American Thyroid Association guidelines and recent advances in systemic treatment such as TKIs for patients with persistent or recurrent MTC after surgery.

Citations

Citations to this article as recorded by  
  • Multiple endocrine neoplasia 2: an overview
    B Saravana-Bawan, JD Pasternak
    Therapeutic Advances in Chronic Disease.2022; 13: 204062232210792.     CrossRef
  • Total thyroidectomy vs thyroid lobectomy for localized medullary thyroid cancer in adults: A propensity-matched survival analysis
    Weili Liang, Jinyuan Shi, Hui Zhang, Guixu Lv, Tiantian Wang, Yong Wang, Bin Lv, Luchuan Li, Qingdong Zeng, Lei Sheng
    Surgery.2022; 172(5): 1385.     CrossRef
  • Naphthoquinones and derivatives as potential anticancer agents: An updated review
    Md Mominur Rahman, Md Rezaul Islam, Shopnil Akash, Sheikh Shohag, Limon Ahmed, Fatema Akter Supti, Abdur Rauf, Abdullah S.M. Aljohani, Waleed Al Abdulmonem, Anees Ahmed Khalil, Rohit Sharma, Muthu Thiruvengadam
    Chemico-Biological Interactions.2022; 368: 110198.     CrossRef
  • Metformin Decreases Serum Thyroglobulin Concentration in Nonmedullary Thyroid Carcinoma
    Celina Caetano, Paola Tabaro Pico, Charan Singh, Beatriz Tendler, Diana M Malchoff, Carl D Malchoff
    Journal of the Endocrine Society.2022;[Epub]     CrossRef
  • Long non-coding RNA LINC00488 facilitates thyroid cancer cell progression through miR-376a-3p/PON2
    Fuyuan Xie, Longgen Li, Yuting Luo, Rensheng Chen, Jinhong Mei
    Bioscience Reports.2021;[Epub]     CrossRef
  • Decision Making When Cancer Becomes Chronic: Needs Assessment for a Web-Based Medullary Thyroid Carcinoma Patient Decision Aid
    Danielle Shojaie, Aubri S Hoffman, Ruth Amaku, Maria E Cabanillas, Julie Ann Sosa, Steven G Waguespack, Mark E Zafereo, Mimi I Hu, Elizabeth E Grubbs
    JMIR Formative Research.2021; 5(7): e27484.     CrossRef
  • Long Non-coding RNA RUNDC3A-AS1 Promotes Lung Metastasis of Thyroid Cancer via Targeting the miR-182-5p/ADAM9
    Dawei Ma, Yan Zhu, Xiao Zhang, Jia Zhang, Wei Chen, Xinyuan Chen, Yichun Qian, Yanbin Zhao, Tingting Hu, Zhangyu Yao, Wei Zhao, Yuan Zhang, Fangzhou Liu
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • Effects of marital status on survival of medullary thyroid cancer stratified by age
    Lei Ai, Ning Li, Hai‐Long Tan, Bo Wei, Ya‐Xin Zhao, Pei Chen, Hui‐Yu Hu, Mian Liu, Deng‐Jie Ou‐Yang, Zi‐en Qin, Peng Huang, Shi Chang
    Cancer Medicine.2021; 10(24): 8829.     CrossRef
  • The prognostic value of lymph node ratio in Medullary thyroid carcinoma: A multi-center study
    Tal Rozenblat, Dania Hirsch, Eyal Robenshtok, Simona Grozinsky-Glasberg, David J. Gross, Haggi Mazeh, Carlos Benbassat, Orit Twito, Sigal Levy, Aviram Mizrachi, Thomas Shpitzer, Gideon Bachar
    European Journal of Surgical Oncology.2020; 46(11): 2023.     CrossRef
  • Multiple Auer Rods in Fine-Needle Aspiration Smears of Medullary Thyroid Carcinoma: An Unusual Finding


    Maryam Mohammadnia Avval, Perikala Vijayananda Kumar, Fereydoon Dehghani
    International Medical Case Reports Journal.2020; Volume 13: 85.     CrossRef
  • Lymph Node Metastases of Medullary Thyroid Cancer: Role of Calcitonin in the Washout Fluid of Fine-Needle Aspiration
    Bernardo Marques, Nuno Cunha, Raquel G. Martins, Ana Rita Elvas, Joana Couto, Jacinta Santos, Teresa Martins, Ana Paula Moniz, Olga Ilhéu, Frederico Valido, Fernando Rodrigues
    International Journal of Endocrinology.2020; 2020: 1.     CrossRef
  • Efficacy and Safety of Vandetanib in Progressive and Symptomatic Medullary Thyroid Cancer: Post Hoc Analysis From the ZETA Trial
    Michael C. Kreissl, Lars Bastholt, Rossella Elisei, Robert Haddad, Ole Hauch, Barbara Jarząb, Bruce Robinson, Raffaella Colzani, Meredith Foster, Richard Weiss, Martin Schlumberger
    Journal of Clinical Oncology.2020; 38(24): 2773.     CrossRef
  • Medullary thyroid cancer: epidemiological pattern and factors contributing to recurrence and metastasis
    O Hamdy, S Awny, IH Metwally
    The Annals of The Royal College of Surgeons of England.2020; 102(7): 499.     CrossRef
  • Carcinoma medular de tiroides estadio iv y gestación
    B. Sánchez Lechuga, C. López Tinoco, I. Gavilán Villarejo, F.J. Vílchez López, M. Aguilar Diosdado
    Clínica e Investigación en Ginecología y Obstetricia.2019; 46(1): 35.     CrossRef
  • Bildgebung beim medullären Schilddrüsenkarzinom
    M. Uhrig, S. Delorme
    Der Radiologe.2019; 59(11): 992.     CrossRef
  • Recent Development of Nuclear Molecular Imaging in Thyroid Cancer
    Huiting Liu, Xiaoqin Wang, Ran Yang, Wenbing Zeng, Dong Peng, Jason Li, Hu Wang
    BioMed Research International.2018; 2018: 1.     CrossRef
  • Radioguided hepatic resection with l -DOPA in metastatic medullary thyroid carcinoma
    Javier López-Gómez, Sevastian Medina-Ornelas, Ma. Alejandra Salazar-Álvarez, Mario Álvarez-Bojórquez, Noel Zaragoza-Cruz, Javier Melchor-Ruan, Alethia Álvarez-Cano
    Revista Española de Medicina Nuclear e Imagen Molecular (English Edition).2018; 37(4): 244.     CrossRef
  • EF24 (a Curcumin Analog) and ZSTK474 Emphasize the Effect of Cabozantinib in Medullary Thyroid Cancer
    Loris Bertazza, Francesca Sensi, Elisabetta Cavedon, Sara Watutantrige-Fernando, Simona Censi, Jacopo Manso, Federica Vianello, Eric Casal Ide, Maurizio Iacobone, Raffaele Pezzani, Caterina Mian, Susi Barollo
    Endocrinology.2018; 159(6): 2348.     CrossRef
  • Resección hepática radioguiada con 18 F-DOPA en un paciente con carcinoma medular de tiroides metastásico
    J. López-Gómez, S. Medina-Ornelas, M.A. Salazar-Álvarez, M. Álvarez-Bojórquez, N. Zaragoza-Cruz, J. Melchor-Ruan, A. Álvarez-Cano
    Revista Española de Medicina Nuclear e Imagen Molecular.2018; 37(4): 244.     CrossRef
  • Genotypic characteristics and their association with phenotypic characteristics of hereditary medullary thyroid carcinoma in Korea
    Kyong Yeun Jung, Seok-Mo Kim, Min Joo Kim, Sun Wook Cho, Bup-Woo Kim, Yong Sang Lee, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung, Kyu Eun Lee, Eun-Jae Chung, Hyo Jeong Kim, Do Joon Park, Myung-Whun Sung, Cheong Soo Park, Bo Youn Cho, Young Joo Park, Han
    Surgery.2018; 164(2): 312.     CrossRef
  • Thyroid cancer management
    Francesco Perri, Antonio Giordano, Salvatore Pisconti, Franco Ionna, Maria G. Chiofalo, Francesco Longo, Davide Leopardo, Giuseppina Della Vittoria Scarpati, Luciano Pezzullo
    Anti-Cancer Drugs.2018; 29(6): 483.     CrossRef
  • Clinicopathological Significance and Prognosis of Medullary Thyroid Microcarcinoma: A Meta-analysis
    Jin Hwa Kim, Jung-Soo Pyo, Won Jin Cho
    World Journal of Surgery.2017; 41(10): 2551.     CrossRef
  • A label-free electrochemical immunosensor based on gold nanoparticles and graphene oxide for the detection of tumor marker calcitonin
    Nawal A. Alarfaj, Maha F. El-Tohamy
    New Journal of Chemistry.2017; 41(19): 11029.     CrossRef
  • Evaluation of in vitro and in vivo activity of a multityrosine kinase inhibitor, AL3810, against human thyroid cancer
    Qin Xie, Hui Chen, Jing Ai, Ying-lei Gao, Mei-yu Geng, Jian Ding, Yi Chen
    Acta Pharmacologica Sinica.2017; 38(11): 1533.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
Editorial
Bone Metabolism
New Biological Markers of Bone Metabolism in Osteoporosis Treatment
Sun Wook Cho
Endocrinol Metab. 2016;31(3):400-401.   Published online September 26, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.400
  • 2,212 View
  • 24 Download
PDFPubReader   CrossRef-TDMCrossref - TDM
Original Articles
Clinical Study
Eligibility for Statin Treatment in Korean Subjects with Reduced Renal Function: An Observational Study
Byung Sub Moon, Jongho Kim, Ji Hyun Kim, Young Youl Hyun, Se Eun Park, Hyung-Geun Oh, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Kyu-Beck Lee, Hyang Kim, Sung-Woo Park, Eun-Jung Rhee
Endocrinol Metab. 2016;31(3):402-409.   Published online August 26, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.402
  • 2,996 View
  • 28 Download
  • 4 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM
Background

The purpose of this study was to investigate the relationship between statin eligibility and the degree of renal dysfunction using the Adult Treatment Panel (ATP) III and the American College of Cardiology (ACC)/American Heart Association (AHA) guidelines in Korean adults.

Methods

Renal function was assessed in 18,746 participants of the Kangbuk Samsung Health Study from January 2011 to December 2012. Subjects were divided into three groups according to estimated glomerular filtration rate (eGFR): stage 1, eGFR ≥90 mL/min/1.73 m2; stage 2, eGFR 60 to 89 mL/min/1.73 m2; and stages 3 to 5, eGFR <60 mL/min/1.73 m2. Statin eligibility in these groups was determined using the ATP III and ACC/AHA guidelines, and the risk for 10-year atherosclerotic cardiovascular disease (ASCVD) was calculated using the Framingham Risk Score (FRS) and Pooled Cohort Equation (PCE).

Results

There were 3,546 (18.9%) and 4,048 (21.5%) statin-eligible subjects according to ATP III and ACC/AHA guidelines, respectively. The proportion of statin-eligible subjects increased as renal function deteriorated. Statin eligibility by the ACC/AHA guidelines showed better agreement with the Kidney Disease Improving Global Outcomes (KDIGO) recommendations compared to the ATP III guidelines in subjects with stage 3 to 5 chronic kidney disease (CKD) (κ value, 0.689 vs. 0.531). When the 10-year ASCVD risk was assessed using the FRS and PCE, the mean risk calculated by both equations significantly increased as renal function declined.

Conclusions

The proportion of statin-eligible subjects significantly increased according to worsening renal function in this Korean cohort. ACC/AHA guideline showed better agreement for statin eligibility with that recommended by KDIGO guideline compared to ATP III in subjects with CKD.

Citations

Citations to this article as recorded by  
  • Association between atherosclerotic cardiovascular diseases risk and renal outcome in patients with type 2 diabetes mellitus
    Honghong Ren, Lijun Zhao, Yutong Zou, Yiting Wang, Junlin Zhang, Yucheng Wu, Rui Zhang, Tingli Wang, Jiali Wang, Yitao Zhu, Ruikun Guo, Huan Xu, Lin Li, Mark E. Cooper, Fang Liu
    Renal Failure.2021; 43(1): 477.     CrossRef
  • Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea
    Seo Yeon Baik, Hyunah Kim, So Jung Yang, Tong Min Kim, Seung-Hwan Lee, Jae Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, Kun-Ho Yoon, Hun-Sung Kim
    Frontiers of Medicine.2019; 13(6): 713.     CrossRef
  • Analysis and comparison of the cost-effectiveness of statins according to the baseline low-density lipoprotein cholesterol level in Korea
    Y. J. Jeong, H. Kim, S. J. Baik, T. M. Kim, S. J. Yang, S.-H. Lee, J.-H. Cho, H. Lee, H. W. Yim, I. Y. Choi, K.-H. Yoon, H.-S. Kim
    Journal of Clinical Pharmacy and Therapeutics.2017; 42(3): 292.     CrossRef
  • Comparison between Atorvastatin and Rosuvastatin in Renal Function Decline among Patients with Diabetes
    Eugene Han, Gyuri Kim, Ji-Yeon Lee, Yong-ho Lee, Beom Seok Kim, Byung-Wan Lee, Bong-Soo Cha, Eun Seok Kang
    Endocrinology and Metabolism.2017; 32(2): 274.     CrossRef
Clinical Study
Prevalence of Hyponatremia in Hypothyroid Patients during Radioactive 131I Ablation for Differentiated Thyroid Cancer: Single Institution Experience
Juan Carlo P. Dayrit, Elaine C. Cunanan, Sjoberg A. Kho
Endocrinol Metab. 2016;31(3):410-415.   Published online August 17, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.410
  • 2,697 View
  • 30 Download
  • 1 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM
Background

Hyponatremia developing in hypothyroid patients has been encountered in clinical practice; however, its prevalence has not been well established.

Methods

Thirty patients diagnosed with differentiated thyroid cancer, rendered hypothyroid after surgery and levothyroxine withdrawal, and who are for radioactive iodine (RAI) ablation were included. Serum sodium concentrations were measured twice, at the time of admission for RAI ablation, and before discharge after increased oral fluid intake. The outcome measures were to determine the prevalence of hyponatremia among hypothyroid patients prior to RAI ablation and after oral hydration post-RAI, and to correlate the serum sodium levels pre-RAI and post-RAI with thyroid-stimulating hormone (TSH) concentration and age.

Results

Thirty patients were included, with ages from 23 to 65 years old (median, 40). Two patients (6.7%) were hyponatremic prior to RAI ablation, and eight patients (26.7%) had mild hyponatremia (130 to 134 mEq/L) after RAI and hydration. There was no significant correlation between TSH levels and serum sodium levels prior to or after RAI. There was also no significant correlation between pre- and post-RAI sodium concentration and age.

Conclusions

The prevalence of hyponatremia pre-RAI was 6.7%, and 26.7% post-RAI. No significant correlation was noted between TSH concentration and age on pre- or post-RAI sodium concentrations. Routine measurement of serum sodium post-RAI/isolation is still not advised. Measurement of sodium post-RAI may be considered in patients who are elderly, with comorbid conditions or on medications.

Citations

Citations to this article as recorded by  
  • Endocrinopathy-induced euvolemic hyponatremia
    Talia Diker-Cohen, Benaya Rozen-Zvi, Dana Yelin, Amit Akirov, Eyal Robenshtok, Anat Gafter-Gvili, Daniel Shepshelovich
    Internal and Emergency Medicine.2018; 13(5): 679.     CrossRef
Clinical Study
Comparison of Age of Onset and Frequency of Diabetic Complications in the Very Elderly Patients with Type 2 Diabetes
Bong-Ki Lee, Sang-Wook Kim, Daehee Choi, Eun-Hee Cho
Endocrinol Metab. 2016;31(3):416-423.   Published online August 26, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.416
  • 2,590 View
  • 36 Download
  • 9 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM
Background

The prevalence of type 2 diabetes in elderly people has increased dramatically in the last few decades. This study was designed to clarify the clinical characteristics of type 2 diabetes in patients aged ≥80 years according to age of onset.

Methods

We reviewed the medical records of 289 patients aged ≥80 years with type 2 diabetes at the outpatient diabetes clinics of Kangwon National University Hospital from September 2010 to June 2014. We divided the patients into middle-age-onset diabetes (onset before 65 years of age) and elderly-onset diabetes (onset at 65+ years of age).

Results

There were 141 male and 148 female patients. The patients had a mean age of 83.2±2.9 years and the mean duration of diabetes was 14.3±10.4 years. One hundred and ninety-nine patients had elderly-onset diabetes. The patients with elderly-onset diabetes had a significantly lower frequency of diabetic retinopathy and nephropathy, lower serum creatinine levels, lower glycated hemoglobin (HbA1c) levels, and similar coronary revascularization and cerebral infarction rates compared to those with middle-age-onset diabetes. There was no frequency difference in coronary revascularization and cerebral infarction and HbA1c levels between three subgroups (<5, 5 to 15, and ≥15 years) of diabetes duration in elderly onset diabetes. However, both in the elderly onset diabetes and middle-age-onset diabetes, the cumulative incidence of retinopathy was increasing rapidly according to the duration of diabetes.

Conclusion

We report that individuals with elderly-onset diabetes have a lower frequency of diabetic retinopathy and nephropathy and similar cardiovascular complications compared to those with middle-age-onset diabetes.

Citations

Citations to this article as recorded by  
  • Rescue of High Glucose Impairment of Cultured Human Osteoblasts Using Cinacalcet and Parathyroid Hormone
    V. A. Shahen, A. Schindeler, M. S. Rybchyn, C. M. Girgis, B. Mulholland, R. S. Mason, I. Levinger, T. C. Brennan-Speranza
    Calcified Tissue International.2023;[Epub]     CrossRef
  • Factors Related to the Occurrence and Number of Chronic Diabetic Complications in Patients with Type 2 Diabetes Mellitus: Utilizing The National Health Insurance Service-National Health Screening Cohort in Korea, 2002~2015
    Haejung Lee, Misoon Lee, Gaeun Park, Ah Reum Khang
    Journal of Korean Gerontological Nursing.2022; 24(1): 22.     CrossRef
  • Prevalence of and Risk Factors for Diabetic Retinopathy and Diabetic Macular Edema in Patients with Early- and Late-Onset Diabetes Mellitus
    Yu Wang, Zhong Lin, Gang Zhai, Xiao Xia Ding, Liang Wen, Dong Li, Bo Zou, Ke Mi Feng, Yuan Bo Liang, Cong Xie
    Ophthalmic Research.2022; 65(3): 293.     CrossRef
  • Associations of Age at Diagnosis and Duration of Diabetes With Morbidity and Mortality Among Older Adults
    Christine T. Cigolle, Caroline S. Blaum, Chen Lyu, Jinkyung Ha, Mohammed Kabeto, Judy Zhong
    JAMA Network Open.2022; 5(9): e2232766.     CrossRef
  • Chart review of diagnostic methods, baseline characteristics and symptoms for European patients with pancreatic cancer
    Alfredo Carrato, Davide Melisi, Gerald Prager, Christoph B Westphalen, Anabel Ferreras, Nathalie D’Esquermes, Julien Taieb, Teresa M Mercadé
    Future Oncology.2021; 17(15): 1843.     CrossRef
  • Distinction of cardiometabolic profiles among people ≥75 years with type 2 diabetes: a latent profile analysis
    Antoine CHRISTIAENS, Michel P. HERMANS, Benoit BOLAND, Séverine HENRARD
    BMC Endocrine Disorders.2019;[Epub]     CrossRef
  • Validity of diagnostic codes and estimation of prevalence of diabetic foot ulcers using a large electronic medical record database
    Avivit Cahn, Talya Altaras, Tal Agami, Ori Liran, Colette E. Touaty, Michel Drahy, Rena Pollack, Itamar Raz, Gabriel Chodick, Inbar Zucker
    Diabetes/Metabolism Research and Reviews.2019; 35(2): e3094.     CrossRef
  • Response: Comparison of Age of Onset and Frequency of Diabetic Complications in the Very Elderly Patients with Type 2 Diabetes (Endocrinol Metab2016;31:416-23, Bong-Ki Lee et al.)
    Eun-Hee Cho
    Endocrinology and Metabolism.2017; 32(1): 142.     CrossRef
  • Letter: Comparison of Age of Onset and Frequency of Diabetic Complications in the Very Elderly Patients with Type 2 Diabetes (Endocrinol Metab2016;31:416-23, Bong-Ki Lee et al.)
    Mee Kyoung Kim
    Endocrinology and Metabolism.2017; 32(1): 140.     CrossRef
Clinical Study
Prognostic Factors in Patients Hospitalized with Diabetic Ketoacidosis
Avinash Agarwal, Ambuj Yadav, Manish Gutch, Shuchi Consul, Sukriti Kumar, Ved Prakash, Anil Kumar Gupta, Annesh Bhattacharjee
Endocrinol Metab. 2016;31(3):424-432.   Published online September 1, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.424
  • 3,277 View
  • 61 Download
  • 22 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM
Background

Diabetic ketoacidosis (DKA) is characterized by a biochemical triad of hyperglycemia, acidosis, and ketonemia. This condition is life-threatening despite improvements in diabetic care. The purpose of this study was to evaluate the clinical and biochemical prognostic markers of DKA. We assessed correlations in prognostic markers with DKA-associated morbidity and mortality.

Methods

Two hundred and seventy patients that were hospitalized with DKA over a period of 2 years were evaluated clinically and by laboratory tests. Serial assays of serum electrolytes, glucose, and blood pH were performed, and clinical outcome was noted as either discharged to home or death.

Results

The analysis indicated that significant predictors included sex, history of type 1 diabetes mellitus or type 2 diabetes mellitus, systolic blood pressure, diastolic blood pressure, total leukocyte count, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, blood urea nitrogen, serum creatinine, serum magnesium, serum phosphate, serum osmolality, serum glutamic oxaloacetic transaminases, serum glutamic pyruvic transaminases, serum albumin, which were further regressed and subjected to multivariate logistic regression (MLR) analysis. The MLR analysis indicated that males were 7.93 times more likely to have favorable outcome compared with female patients (odds ratio, 7.93; 95% confidence interval, 3.99 to 13.51), while decreases in mean APACHE II score (14.83) and serum phosphate (4.38) at presentation may lead to 2.86- and 2.71-fold better outcomes, respectively, compared with higher levels (APACHE II score, 25.00; serum phosphate, 6.04).

Conclusion

Sex, baseline biochemical parameters such as APACHE II score, and phosphate level were important predictors of the DKA-associated mortality.

Citations

Citations to this article as recorded by  
  • Clinical characteristics of people with diabetic ketoacidosis at a clinic in The Gambia: a retrospective study
    Orighomisan F Agboghoroma, Modou Jobe, Karen Forrest
    Journal of Endocrinology, Metabolism and Diabetes of South Africa.2023; 28(1): 14.     CrossRef
  • Elevated alanine transaminase is nonlinearly associated with in-hospital death in ICU-admitted diabetic ketoacidosis patients
    Qiaoling Liu, Chen Gong, Yunjie Geng, Jiuhong You
    Diabetes Research and Clinical Practice.2023; 197: 110555.     CrossRef
  • Clinical Profile and Outcome of Diabetic Ketoacidosis in Type 1 and Type 2 Diabetes: A Comparative Study
    Sachin Kamle, Madhuri Holay, Prashant Patil, Parimal Tayde
    Vidarbha Journal of Internal Medicine.2022; 32: 21.     CrossRef
  • Effect of subjective tool based aerobic exercise on pulmonary functions in patients with type 2 diabetes mellitus – a feasibility RCT
    M. Saini, J. Kaur
    Comparative Exercise Physiology.2022; 18(3): 239.     CrossRef
  • Clinical characteristics and outcomes of care in patients hospitalized with diabetic ketoacidosis
    Mohsen S. Eledrisi, Haifaa Alkabbani, Malk Aboawon, Aya Ali, Imad Alabdulrazzak, Maab Elhaj, Ashraf Ahmed, Hazim Alqahwachi, Joanne Daghfal, Salem A. Beshyah, Rayaz A. Malik
    Diabetes Research and Clinical Practice.2022; 192: 110041.     CrossRef
  • An Audit of Factors Impacting the Time to Resolution of the Metabolic Parameters in Diabetic Ketoacidosis Patients
    Muath F AlWahbi , Sami H Alharbi, Saleh A Almesned, Faisal A Alfawzan, Rayan T Alsager, Abdullah A AlHojailan, Emad A Alfadhel, Fahad G Al-Harbi
    Cureus.2022;[Epub]     CrossRef
  • Incidence of Diabetic Ketoacidosis among Adults with Type 1 Diabetes in Saudi Arabia: Systematic review
    Ayoub Ali Alshaikh, Rawan Zaifallh Alsalman, Nada Hamzah Albarqi, Razan Salem Alqahtani, Ali Ahmed Almontashri, Atheer Saud Alshahrani, Mohammed Abdullah Alshehri
    Pharmacophore.2022; 13(4): 105.     CrossRef
  • Features and long‐term outcomes of patients hospitalized for diabetic ketoacidosis
    Michal Michaelis, Tzippy Shochat, Ilan Shimon, Amit Akirov
    Diabetes/Metabolism Research and Reviews.2021;[Epub]     CrossRef
  • Incidence, characteristics and long-term outcomes of patients with diabetic ketoacidosis: a prospective prognosis cohort study in an emergency department
    Rachel Teixeira Leal Nunes, Carolina Frade Magalhães Girardin Pimentel Mota, Paulo Ricardo Gessolo Lins, Fernanda Salles Reis, Thais Castanheira de Freitas Resende, Ludmila de Andrade Barberino, Pedro Henrique Luiz da Silva, Aecio Flavio Teixeira de Gois
    Sao Paulo Medical Journal.2021; 139(1): 10.     CrossRef
  • Management of diabetic ketoacidosis in special populations
    Mohsen S. Eledrisi, Salem A. Beshyah, Rayaz A. Malik
    Diabetes Research and Clinical Practice.2021; 174: 108744.     CrossRef
  • Profile of diabetic ketoacidosis at the National Diabetes and Endocrine Center in Tripoli, Libya, 2015
    Aida Elkituni, Halla Elshwekh, Nesrein M. Bendala, Wafeya S. Atwear, Fawzia A. Aldaba, Abdulmunam M. Fellah
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2021; 15(3): 771.     CrossRef
  • Frequency of Diabetic Ketoacidosis and Its Determinants Among Pediatric Diabetes Mellitus Patients in Northwest Ethiopia
    Atitegeb Abera Kidie, Ayenew Molla Lakew, Tiruneh Ayele
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 4819.     CrossRef
  • Diabetic ketoacidosis
    Ketan K. Dhatariya, Nicole S. Glaser, Ethel Codner, Guillermo E. Umpierrez
    Nature Reviews Disease Primers.2020;[Epub]     CrossRef
  • Risk and Relevance of Insulin Pump Therapy in the Aetiology of Ketoacidosis in People with Type 1 Diabetes
    Lena Christina Giessmann, Peter Herbert Kann
    Experimental and Clinical Endocrinology & Diabetes.2020; 128(11): 745.     CrossRef
  • Clinical and biochemical profile, precipitants and prognostic factors of diabetic ketoacidosis: A retrospective study from a tertiary care center of north India
    Harpreet Singh, Atul Saroch, Ashok Kumar Pannu, H.J. Sachin, Navneet Sharma, Pinaki Dutta
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(4): 2357.     CrossRef
  • Sudden death due to diabetic ketoacidosis following power failure of an insulin pump: Autopsy and pump data
    Mette Louise Blouner Gram Kjærulff, Birgitte Schmidt Astrup
    Journal of Forensic and Legal Medicine.2019; 63: 34.     CrossRef
  • Defining and characterising diabetic ketoacidosis in adults
    Ketan K. Dhatariya
    Diabetes Research and Clinical Practice.2019; 155: 107797.     CrossRef
  • Effects of diabetic ketoacidosis in the respiratory system
    Alice Gallo de Moraes, Salim Surani
    World Journal of Diabetes.2019; 10(1): 16.     CrossRef
  • Increasing Hospitalizations for DKA: A Need for Prevention Programs
    Priyathama Vellanki, Guillermo E. Umpierrez
    Diabetes Care.2018; 41(9): 1839.     CrossRef
  • Guidelines and controversies in the management of diabetic ketoacidosis – A mini-review
    Tasnim Islam, Khalid Sherani, Salim Surani, Abhay Vakil
    World Journal of Diabetes.2018; 9(12): 226.     CrossRef
  • Closing the Mortality Gap in Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State: Implications of a Clinical Decision Support App
    Saperstein Y, Park J, McFarlane SI
    International Journal of Clinical Endocrinology and Metabolism.2018; : 008.     CrossRef
  • Incidence and prevalence of diabetic ketoacidosis (DKA) among adults with type 1 diabetes mellitus (T1D): a systematic literature review
    Soulmaz Fazeli Farsani, Kimberly Brodovicz, Nima Soleymanlou, Jan Marquard, Erika Wissinger, Brett A Maiese
    BMJ Open.2017; 7(7): e016587.     CrossRef
Clinical Study
Osteoporosis and Prevalent Fractures among Adult Filipino Men Screened for Bone Mineral Density in a Tertiary Hospital
Erick S. Mendoza, Amy A. Lopez, Valerie Ann U. Valdez, Leilani B. Mercado-Asis
Endocrinol Metab. 2016;31(3):433-438.   Published online August 16, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.433
  • 3,353 View
  • 36 Download
  • 5 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM
Background

Osteoporosis in men is markedly underdiagnosed and undertreated despite higher morbidity and mortality associated with fractures. This study aimed to characterize adult Filipino men with osteopenia, osteoporosis and prevalent fractures.

Methods

A cross-sectional study of 184 Filipino men ≥50 years screened for bone mineral density was performed. Age, weight, body mass index (BMI), Osteoporosis Self-Assessment Tool for Asians (OSTA) score, smoking status, family history of fracture, diabetes mellitus, physical inactivity, and T-score were considered.

Results

Of the 184 patients, 40.2% and 29.9% have osteopenia and osteoporosis. Sixteen (21.6%) and 18 (32.1%) osteopenic and osteoporotic men have fragility hip, spine, or forearm fractures. Men aged 50 to 69 years have the same risk of osteoporosis and fractures as those ≥70 years. While hip fractures are higher in osteoporotic men, vertebral fractures are increased in both osteopenic and osteoporotic men. Mere osteopenia predicts the presence of prevalent fractures. A high risk OSTA score can predict fracture. A BMI <21 kg/m2 (P<0.05) and current smoking are associated with osteoporosis.

Conclusion

A significant fraction of Filipino men with osteopenia and osteoporosis have prevalent fractures. Our data suggest that fractures occur in men <70 years even before osteoporosis sets in. Low BMI, high OSTA score, and smoking are significant risk factors of osteoporosis.

Citations

Citations to this article as recorded by  
  • Assessment of Osteoporosis Awareness and Osteoporosis Risk Level of Patients Admitted to a University Hospital
    Turkan Pasali Kilit, Kevser Onbasi, Filiz Ozyigit
    Journal of Clinical Densitometry.2022; 25(4): 528.     CrossRef
  • Current status and challenges in the management of osteoporosis among men in the Philippines
    Abraham C. Sianoya, Eric David B. Ornos, Jerico R. Santos, Ourlad Alzeus G. Tantengco, Cecilia A. Jimeno
    Archives of Osteoporosis.2022;[Epub]     CrossRef
  • Bone Mineral Density Among Men and Women Aged 35 to 50 Years
    Martha A. Bass, Ankita Sharma, Vinayak K. Nahar, Stacy Chelf, Brittany Zeller, Linda Pham, M. Allison Ford
    Journal of Osteopathic Medicine.2019; 119(6): 357.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
  • A review on the performance of osteoporosis self-assessment tool for Asians in determining osteoporosis and fracture risk
    Kok-Yong Chin
    Postgraduate Medicine.2017; 129(7): 734.     CrossRef
Clinical Study
Correlation of Glypican-4 Level with Basal Active Glucagon-Like Peptide 1 Level in Patients with Type 2 Diabetes Mellitus
Sang Ah Lee, Gwanpyo Koh, Suk Ju Cho, So-Yeon Yoo, Sang Ouk Chin
Endocrinol Metab. 2016;31(3):439-445.   Published online September 26, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.439
  • 3,277 View
  • 35 Download
  • 7 Citations
AbstractAbstract PDFSupplementary MaterialPubReader   CrossRef-TDMCrossref - TDM
Background

Previous studies have reported that glypican-4 (GPC4) regulates insulin signaling by interacting with insulin receptor and through adipocyte differentiation. However, GPC4 has not been studied with regard to its effects on clinical factors in patients with type 2 diabetes mellitus (T2DM). We aimed to identify factors associated with GPC4 level in T2DM.

Methods

Between January 2010 and December 2013, we selected 152 subjects with T2DM and collected serum and plasma into tubes pretreated with aprotinin and dipeptidyl peptidase-4 inhibitor to preserve active gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1). GPC4, active GLP-1, active GIP, and other factors were measured in these plasma samples. We performed a linear regression analysis to identify factors associated with GPC4 level.

Results

The subjects had a mean age of 58.1 years, were mildly obese (mean body mass index [BMI], 26.1 kg/m2), had T2DM of long-duration (mean, 101.3 months), glycated hemoglobin 7.5%, low insulin secretion, and low insulin resistance (mean homeostatic model assessment of insulin resistance [HOMA-IR], 1.2). Their mean GPC4 was 2.0±0.2 ng/mL. In multivariate analysis, GPC4 was independently associated with age (β=0.224, P=0.009), and levels of active GLP-1 (β=0.171, P=0.049) and aspartate aminotransferase (AST; β=–0.176, P=0.043) after being adjusted for other clinical factors.

Conclusion

GPC4 was independently associated with age, active GLP-1, and AST in T2DM patients, but was not associated with HOMA-IR and BMI, which are well known factors related to GPC4. Further study is needed to identify the mechanisms of the association between GPC4 and basal active GLP-1 levels.

Citations

Citations to this article as recorded by  
  • How Reliable are Commercially Available Glypican4 ELISA Kits?
    Joseph P. Buhl, Antje Garten, Jürgen Kratzsch, Wieland Kiess, Melanie Penke
    Experimental and Clinical Endocrinology & Diabetes.2022; 130(02): 110.     CrossRef
  • Serum glypican-4 is associated with the 10-year clinical outcome of patients with peripheral artery disease
    Axel Muendlein, Christine Heinzle, Andreas Leiherer, Kathrin Geiger, Eva Maria Brandtner, Stella Gaenger, Peter Fraunberger, Christoph H. Saely, Heinz Drexel
    International Journal of Cardiology.2022; 369: 54.     CrossRef
  • Berberine activates the β-catenin/TCF4 signaling pathway by down-regulating miR-106b to promote GLP-1 production by intestinal L cells
    Jiao Wang, Li-Rui Wei, Yan-Ling Liu, Cheng-Zhi Ding, Feng Guo, Jiao Wang, Qian Qin, Feng-Jiao Huang, Ying Xin, Sheng-Nan Ma, Qiu-Ran Zhai, Shou-Jun Wang, Gui-Jun Qin
    European Journal of Pharmacology.2021; 911: 174482.     CrossRef
  • Increased Glypican-4 Levels Are Associated with Obesity in Adolescents
    Huseyin Dag, Nevin Cetin Dag, Okan Dikker
    Iranian Journal of Pediatrics.2019;[Epub]     CrossRef
  • Serum glypican 4 level in obese children and its relation to degree of obesity
    Chutima Leelalertlauw, Manassawee Korwutthikulrangsri, Pat Mahachoklertwattana, Suwannee Chanprasertyothin, Patcharin Khlairit, Sarunyu Pongratanakul, Preamrudee Poomthavorn
    Clinical Endocrinology.2017; 87(6): 689.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
  • Efficacy and Safety of Single‐ or Double‐Drug Antidiabetic Regimens in the Treatment of Type 2 Diabetes Mellitus: A Network Meta‐Analysis
    Xi‐Ling Yang, Mi‐Ma Duo‐Ji, Zi‐Wen Long
    Journal of Cellular Biochemistry.2017; 118(12): 4536.     CrossRef
Clinical Study
Prevalence of Reduced Kidney Function by Estimated Glomerular Filtration Rate Using an Equation Based on Creatinine and Cystatin C in Metabolic Syndrome and Its Components in Korean Adults
Yang Ho Kang, Dong Wook Jeong, Seok Man Son
Endocrinol Metab. 2016;31(3):446-453.   Published online August 2, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.446
  • 2,755 View
  • 29 Download
  • 4 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM
Background

It is known that metabolic syndrome (MetS) is associated with chronic kidney disease. We evaluated and compared the prevalence of reduced kidney function in MetS and its components by estimated glomerular filtration rate (eGFR) using an equation based on creatinine (eGFRcr), cystatin C (eGFRcys), and combined creatinine-cystatin C (eGFRcr-cys) in Korean adults.

Methods

We analyzed data from 3,649 adults who participated in a comprehensive health examination.

Results

Mean values of eGFRcys were higher compared with mean values of eGFRcr (96.1±18.2 mL/min/1.73 m2 vs. 91.2±13.6 mL/min/1.73 m2) in total subjects. The prevalence of reduced kidney function increased with age (9.6% for eGFRcys vs. 5.8% for eGFRcr-cys vs. 4.9% for eGFRcr, in subjects aged ≥60 years), and significantly increased with MetS, abdominal obesity, hypertension, high triglyceride, low high density lipoprotein (HDL), and high insulin resistance. The prevalence of MetS, abdominal obesity, hypertension, high insulin resistance, low HDL, and hepatic steatosis was significantly increased in subjects with reduced kidney function. This increased prevalence and the odds ratio of reduced kidney function for prevalence of MetS was highest for eGFRcys, followed by those of eGFRcr-cys, and eGFRcr.

Conclusion

The prevalence of reduced kidney function by eGFR was significantly increased in subjects with MetS and its related components. eGFRcys and eGFRcr-cys were superior to eGFRcr in detecting reduced kidney function.

Citations

Citations to this article as recorded by  
  • Association Between CST3 Gene Polymorphisms and Large-Artery Atherosclerotic Stroke
    Yarong Ding, Zhe Xu, Yuesong Pan, Xia Meng, Xianglong Xiang, Hao Li, Liping Liu, Yongjun Wang
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea
    Seo Yeon Baik, Hyunah Kim, So Jung Yang, Tong Min Kim, Seung-Hwan Lee, Jae Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, Kun-Ho Yoon, Hun-Sung Kim
    Frontiers of Medicine.2019; 13(6): 713.     CrossRef
  • Gender specific association of parathyroid hormone and vitamin D with metabolic syndrome in population with preserved renal function
    Min-Hee Kim, Jeongmin Lee, Jeonghoon Ha, Kwanhoon Jo, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo-Il Kang, Bong Yun Cha
    Scientific Reports.2018;[Epub]     CrossRef
  • PROBLEM OF THE ASSESMENT OF GLOMERULAR FILTRATION RATE IN OBESITY
    A. V. Smirnov, I. G. Kayukov, A. Sh. Rumyantsev
    Nephrology (Saint-Petersburg).2017; 21(2): 20.     CrossRef

Endocrinol Metab : Endocrinology and Metabolism