Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Previous issues

Page Path
HOME > BROWSE ARTICLES > Previous issues
17 Previous issues
Filter
Filter
Article type
Keywords
Authors
Volume 30(2); June 2015
Prev issue Next issue
Review Articles
Thyroid
Mitochondrial Energy Metabolism and Thyroid Cancers
Junguee Lee, Joon Young Chang, Yea Eun Kang, Shinae Yi, Min Hee Lee, Kyong Hye Joung, Kun Soon Kim, Minho Shong
Endocrinol Metab. 2015;30(2):117-123.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.117
  • 4,043 View
  • 48 Download
  • 15 Web of Science
  • 16 Crossref
AbstractAbstract PDFPubReader   

Primary thyroid cancers including papillary, follicular, poorly differentiated, and anaplastic carcinomas show substantial differences in biological and clinical behaviors. Even in the same pathological type, there is wide variability in the clinical course of disease progression. The molecular carcinogenesis of thyroid cancer has advanced tremendously in the last decade. However, specific inhibition of oncogenic pathways did not provide a significant survival benefit in advanced progressive thyroid cancer that is resistant to radioactive iodine therapy. Accumulating evidence clearly shows that cellular energy metabolism, which is controlled by oncogenes and other tumor-related factors, is a critical factor determining the clinical phenotypes of cancer. However, the role and nature of energy metabolism in thyroid cancer remain unclear. In this article, we discuss the role of cellular energy metabolism, particularly mitochondrial energy metabolism, in thyroid cancer. Determining the molecular nature of metabolic remodeling in thyroid cancer may provide new biomarkers and therapeutic targets that may be useful in the management of refractory thyroid cancers.

Citations

Citations to this article as recorded by  
  • Exploring the clinical utility of DPP-IV and SGLT2 inhibitors in papillary thyroid cancer: a literature review
    Angelika Buczyńska, Maria Kościuszko, Adam Jacek Krętowski, Anna Popławska-Kita
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Liquid Biopsy as a Method for Minimally Invasive Diagnosis of Thyroid Cancer
    Tagir I. Rakhmatullin, Mark Jain, Larisa M. Samokhodskaya, Vladimir A. Zhivotov
    Journal of Clinical Practice.2023; 14(3): 69.     CrossRef
  • Development of Metabolic Synthetic Lethality and Its Implications for Thyroid Cancer
    Sang-Hyeon Ju, Seong Eun Lee, Yea Eun Kang, Minho Shong
    Endocrinology and Metabolism.2022; 37(1): 53.     CrossRef
  • Monensin Inhibits Anaplastic Thyroid Cancer via Disrupting Mitochondrial Respiration and AMPK/mTOR Signaling
    Yanli Li, Qianshu Sun, Sisi Chen, Xiongjie Yu, Hongxia Jing
    Anti-Cancer Agents in Medicinal Chemistry.2022; 22(14): 2539.     CrossRef
  • Growth Differentiation Factor 15 is a Cancer Cell-Induced Mitokine That Primes Thyroid Cancer Cells for Invasiveness
    Yea Eun Kang, Jin Man Kim, Mi Ae Lim, Seong Eun Lee, Shinae Yi, Jung Tae Kim, Chan Oh, Lihua Liu, Yanli Jin, Seung-Nam Jung, Ho-Ryun Won, Jae Won Chang, Jeong Ho Lee, Hyun Jung Kim, Hyun Yong Koh, Sangmi Jun, Sun Wook Cho, Minho Shong, Bon Seok Koo
    Thyroid.2021; 31(5): 772.     CrossRef
  • Clinical Significance of the D-Loop Gene Mutation in Mitochondrial DNA in Laryngeal Cancer
    Lei Wang, He-Xiang Cheng, Yan-Hui Zhou, Min Ma
    OncoTargets and Therapy.2021; Volume 14: 3461.     CrossRef
  • Transcriptomic and Genetic Associations between Alzheimer’s Disease, Parkinson’s Disease, and Cancer
    Jaume Forés-Martos, Cesar Boullosa, David Rodrigo-Domínguez, Jon Sánchez-Valle, Beatriz Suay-García, Joan Climent, Antonio Falcó, Alfonso Valencia, Joan Anton Puig-Butillé, Susana Puig, Rafael Tabarés-Seisdedos
    Cancers.2021; 13(12): 2990.     CrossRef
  • KLF5 influences cell biological function and chemotherapy sensitivity through the JNK signaling pathway in anaplastic thyroid carcinoma
    Zheng Wang, Xinguang Qiu, Hao Zhang, Weihan Li
    Journal of Biochemical and Molecular Toxicology.2020;[Epub]     CrossRef
  • Metabolic reprogramming related to whole-chromosome instability in models for Hürthle cell carcinoma
    Ruben D. Addie, Sarantos Kostidis, Willem E. Corver, Jan Oosting, Sepideh Aminzadeh-Gohari, René G. Feichtinger, Barbara Kofler, Mehtap Derya Aydemirli, Martin Giera, Hans Morreau
    Scientific Reports.2020;[Epub]     CrossRef
  • Inhibition of mitochondrial respiration by tigecycline selectively targets thyroid carcinoma and increases chemosensitivity
    Yuehua Wang, Fei Xie, Dejie Chen, Ling Wang
    Clinical and Experimental Pharmacology and Physiology.2019; 46(10): 890.     CrossRef
  • Investigating Therapeutic Effects of Retinoic Acid on Thyroid Cancer via Protein-Protein Interaction Network Analysis
    Majid Rezaei-Tavirani, Mostafa Rezaei-Tavirani, Mona Zamanian Azodi
    International Journal of Cancer Management.2019;[Epub]     CrossRef
  • CASE REPORT: An Extensively Necrotic Hürthle-Cell Carcinoma Mimicked a Thyroid Abscess
    Sanders H. Lin, Shih-Ming Huang, Su-Lin Peng
    Clinical Thyroidology.2018; 30(11): 529.     CrossRef
  • Atovaquone enhances doxorubicin’s efficacy via inhibiting mitochondrial respiration and STAT3 in aggressive thyroid cancer
    Zhuo Lv, Xintong Yan, Liying Lu, Chun Su, Yin He
    Journal of Bioenergetics and Biomembranes.2018; 50(4): 263.     CrossRef
  • Identification of novel biomarker and therapeutic target candidates for diagnosis and treatment of follicular carcinoma
    Xianyin Lai, Christopher B. Umbricht, Kurt Fisher, Justin Bishop, Qiuying Shi, Shaoxiong Chen
    Journal of Proteomics.2017; 166: 59.     CrossRef
  • Pathological processes and therapeutic advances in radioiodide refractory thyroid cancer
    Marika H Tesselaar, Johannes W Smit, James Nagarajah, Romana T Netea-Maier, Theo S Plantinga
    Journal of Molecular Endocrinology.2017; 59(4): R141.     CrossRef
  • Integrated microRNA, gene expression and transcription factors signature in papillary thyroid cancer with lymph node metastasis
    Nurul-Syakima Ab Mutalib, Sri Noraima Othman, Azliana Mohamad Yusof, Shahrun Niza Abdullah Suhaimi, Rohaizak Muhammad, Rahman Jamal
    PeerJ.2016; 4: e2119.     CrossRef
Close layer
Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders
Holly Clarke, Waljit S. Dhillo, Channa N. Jayasena
Endocrinol Metab. 2015;30(2):124-141.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.124
  • 9,111 View
  • 154 Download
  • 107 Web of Science
  • 100 Crossref
AbstractAbstract PDFPubReader   

Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of gonadotrophin releasing hormone (GnRH). Loss of kisspeptin signaling causes hypogonadotrophic hypogonadism in humans and other mammals. Kisspeptin interacts with other neuropeptides such as neurokinin B and dynorphin, to regulate GnRH pulse generation. In addition, a growing body of evidence suggests that kisspeptin signaling be regulated by nutritional status and stress. Kisspeptin may also represent a novel potential therapeutic target in the treatment of fertility disorders. Early human studies suggest that peripheral exogenous kisspeptin administration stimulates gonadotrophin release in healthy adults and in patients with certain forms of infertility. This review aims to concisely summarize what is known about kisspeptin as a regulator of reproductive function, and provide an update on recent advances within this field.

Citations

Citations to this article as recorded by  
  • A prospective study to evaluate whether serum kisspeptin is a marker predictive of the first-trimester miscarriage of women who conceive in IVF
    He Li, Wenbi Zhang, Xiaoxi Sun
    Journal of Assisted Reproduction and Genetics.2024; 41(1): 79.     CrossRef
  • Kisspeptin stimulates sheep ovarian follicular development in vitro through homologous receptors
    B. Divya Sri, S. Harsha Lekha, K. Narendra Gopal Reddy, Deepa Pathipati, B. Rambabu Naik, P. Jagapathy Ramayya, K. Veera Bramhaiah, L.S.S. Varaprasad Reddy, A.V.N. Siva Kumar
    Zygote.2024; 32(1): 49.     CrossRef
  • Multiomics Analysis–Based Biomarkers in Diagnosis of Polycystic Ovary Syndrome
    Shikha Rani, Piyush Chandna
    Reproductive Sciences.2023; 30(1): 1.     CrossRef
  • Female Infertility Is Associated with an Altered Expression Profile of Different Members of the Tachykinin Family in Human Granulosa Cells
    Víctor Blasco, Francisco M. Pinto, Ainhoa Fernández-Atucha, Nicolás Prados Dodd, Manuel Fernández-Sánchez, Luz Candenas
    Reproductive Sciences.2023; 30(1): 258.     CrossRef
  • Impact of Ovariectomy on the Anterior Pituitary Gland in Female Rats
    Aki Oride, Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Hiroe Okada, Zhuoma Cairang, Kyo Satoru, Anna Hejmej
    International Journal of Endocrinology.2023; 2023: 1.     CrossRef
  • Male infertility in diabetes mellitus: An insight into the pathophysiology
    AB. M. Kamrul-Hasan, FatemaTuz Zahura Aalpona, Sowrabha Bhat, Sunetra Mondal, Arundhati Dasgupta, Shahjada Selim
    Bangladesh Journal of Endocrinology and Metabolism.2023; 2(2): 65.     CrossRef
  • High Prolactin Concentration Induces Ovarian Granulosa Cell Oxidative Stress, Leading to Apoptosis Mediated by L-PRLR and S-PRLR
    Ruochen Yang, Chunhui Duan, Shuo Zhang, Yunxia Guo, Xinyu Shan, Meijing Chen, Sicong Yue, Yingjie Zhang, Yueqin Liu
    International Journal of Molecular Sciences.2023; 24(19): 14407.     CrossRef
  • Kisspeptin-mediated improvement of sensitivity to BRAF inhibitors in vemurafenib-resistant melanoma cells
    Carlotta Guzzetti, Cristina Corno, Elisabetta Vergani, Luca Mirra, Emilio Ciusani, Monica Rodolfo, Paola Perego, Giovanni L. Beretta
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Impose of KNDy/GnRH neural circuit in PCOS, ageing, cancer and Alzheimer’s disease: StAR actions in prevention of neuroendocrine dysfunction
    Siva Prasad Panda, Adarsh Kesharwani, Gaurav Deep Singh, DSNBK Prasanth, Bhaskara Raju Vatchavai, P.V. Kamala Kumari, Sunil Kumar Panda, Sarada Prasanna Mallick
    Ageing Research Reviews.2023; 92: 102086.     CrossRef
  • Elucidation of the genetic determination of clutch traits in Chinese local chickens of the Laiwu Black breed
    Jie Wang, Zhansheng Liu, Dingguo Cao, Jie Liu, Fuwei Li, Heguo Han, Haixia Han, Qiuxia Lei, Wei Liu, Dapeng Li, Jianxia Wang, Yan Zhou
    BMC Genomics.2023;[Epub]     CrossRef
  • Metabolic actions of kisspeptin signaling: Effects on body weight, energy expenditure, and feeding
    Alexandra D. Hudson, Alexander S. Kauffman
    Pharmacology & Therapeutics.2022; 231: 107974.     CrossRef
  • Intraperitoneal kisspeptin‐10 administration ameliorates sodium arsenite‐induced reproductive toxicity in adult male mice
    Iffat Fatima, Irfan Zia Qureshi
    Andrologia.2022;[Epub]     CrossRef
  • The relation between obesity, kisspeptin, leptin, and male fertility
    Saber Ghaderpour, Rafighe Ghiasi, Hamed Heydari, Rana Keyhanmanesh
    Hormone Molecular Biology and Clinical Investigation.2022; 43(2): 235.     CrossRef
  • Genistein affects gonadotrophin-releasing hormone secretion in GT1-7 cells via modulating kisspeptin receptor and key regulators
    Jingyuan Xiong, Ye Tian, Aru Ling, Zhenmi Liu, Li Zhao, Guo Cheng
    Systems Biology in Reproductive Medicine.2022; 68(2): 138.     CrossRef
  • Ovarian cancer and KiSS-1 gene expression: A consideration of the use of Kisspeptin plus Kisspeptin aptamers in diagnostics and therapy
    Navinder Singh, Richard Hutson, Nathaniel G.N. Milton, Farideh A. Javid
    European Journal of Pharmacology.2022; 917: 174752.     CrossRef
  • In vivo imaging of the GnRH pulse generator reveals a temporal order of neuronal activation and synchronization during each pulse
    Aleisha M. Moore, Lique M. Coolen, Michael N. Lehman
    Proceedings of the National Academy of Sciences.2022;[Epub]     CrossRef
  • The role of leptin and low testosterone in obesity
    Kajal Khodamoradi, Zahra Khosravizadeh, Deepa Seetharam, Suresh Mallepalli, Natoli Farber, Himanshu Arora
    International Journal of Impotence Research.2022; 34(7): 704.     CrossRef
  • Chlorobisphenol A activated kisspeptin/GPR54-GnRH neuroendocrine signals through ERα and GPER pathway in neuronal GT1-7 cells
    Bingli Lei, Lanbing Xu, Yaoyao Huang, Yun Liu, Mengjie Yu, Qianqian Tang
    Ecotoxicology and Environmental Safety.2022; 233: 113290.     CrossRef
  • Genetic factors in precocious puberty
    Young Suk Shim, Hae Sang Lee, Jin Soon Hwang
    Clinical and Experimental Pediatrics.2022; 65(4): 172.     CrossRef
  • Hyperandrogenism induces proportional changes in the expression of Kiss-1, Tac2, and DynA in hypothalamic KNDy neurons
    Hiroe Okada, Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Aki Oride, Satoru Kyo
    Reproductive Biology and Endocrinology.2022;[Epub]     CrossRef
  • Kisspeptin‐10 in cryodiluent improves the post‐thaw quality of Nili‐Ravi buffalo ( Bubalus bubalis ) bull spermatozoa
    Muhammad Hammad Fayyaz, Syed Murtaza Hassan Andrabi, Muhammad Shafiq Haider, Mubashir Ali Khalique, Syed Aftab Hussain Shah
    Andrologia.2022;[Epub]     CrossRef
  • The role of Kisspeptin signaling in Oocyte maturation
    Saeed Masumi, Eun Bee Lee, Iman Dilower, Sameer Upadhyaya, V. Praveen Chakravarthi, Patrick E. Fields, M. A. Karim Rumi
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Use of kisspeptin to trigger oocyte maturation during in vitro fertilisation (IVF) treatment
    Bhavna Sharma, Kanyada Koysombat, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Neurotransmitters, neuropeptides and calcium in oocyte maturation and early development
    Maitha M. Alhajeri, Rayyah R. Alkhanjari, Rawad Hodeify, Ali Khraibi, Hamdan Hamdan
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Sex-specific association between urinary kisspeptin and pubertal development
    Rafaella Sales de Freitas, Thiago F A França, Sabine Pompeia
    Endocrine Connections.2022;[Epub]     CrossRef
  • Overexpression of KiSS1 Induces the Proliferation of Hepatocarcinoma and Increases Metastatic Potential by Increasing Migratory Ability and Angiogenic Capacity
    Cho-Won Kim, Hong Kyu Lee, Min-Woo Nam, Youngdong Choi, Kyung-Chul Choi
    Molecules and Cells.2022; 45(12): 935.     CrossRef
  • Obesity and male infertility: Mechanisms and management
    Kristian Leisegang, Pallav Sengupta, Ashok Agarwal, Ralf Henkel
    Andrologia.2021;[Epub]     CrossRef
  • Interrelationships between kisspeptin and FSH in control of porcine ovarian cell functions
    Z. Fabová, A.V. Sirotkin
    Domestic Animal Endocrinology.2021; 74: 106520.     CrossRef
  • Effects of Recombinant Human Growth Hormone on the Onset of Puberty, Leydig Cell Differentiation, Spermatogenesis and Hypothalamic KISS1 Expression in Immature Male Rats
    Kyoung Huh, Won Heun Nah, Yang Xu, Mi Jung Park, Myung Chan Gye
    The World Journal of Men's Health.2021; 39(2): 381.     CrossRef
  • The effect of different exogenous kisspeptins on sex hormones and reproductive indices of the goldfish (Carassius auratus) broodstock
    AbdolMajid Valipour, Behrooz Heidari, S. Mohsen Asghari, Saeed Balalaie, Hanieh Rabouti, Navid Omidian
    Journal of Fish Biology.2021; 98(4): 1137.     CrossRef
  • Roles of kisspeptin in IVF/ICSI-treated infertile women and in human granulosa cells
    Lixian Qin, Chantacha Sitticharoon, Somsin Petyim, Issarawan Keadkraichaiwat, Rungnapa Sririwichitchai, Pailin Maikeaw, Malika Churintaraphan, Chanakarn Sripong
    Experimental Biology and Medicine.2021; 246(8): 996.     CrossRef
  • Expression analysis of neuropeptide FF receptors on neuroendocrine-related neurons in the rat brain using highly sensitive in situ hybridization
    Shimpei Higo, Moeko Kanaya, Hitoshi Ozawa
    Histochemistry and Cell Biology.2021; 155(4): 465.     CrossRef
  • Pyometra and estrous cycle modulate the uterine expression of the kisspeptin system and angiogenic and immune factors in cats
    Luciano Cardoso Santos, Jeane Martinha dos Anjos Cordeiro, Larissa da Silva Santana, Larissa Rodrigues Santana, Bianca Reis Santos, Erikles Macêdo Barbosa, Thayná Queiroz Menezes da Silva, Janaina Maria Xavier Corrêa, Mário Sergio Lima Lavor, Elisângela B
    Biology of Reproduction.2021; 104(3): 548.     CrossRef
  • Kisspeptin regulates the development of caprine primordial follicles in vitro
    Manjula Priyantha Sumith Magamage, Sriravali Sathagopam, Kiran Avula, Di Neththi Nimesh Madushanka, Sathya Velmurugan
    Journal of Animal Reproduction and Biotechnology.2021; 36(1): 51.     CrossRef
  • Kisspeptin-10 Administration Regulates mTOR and AKT Activities and Oxidative Stress in Mouse Cardiac Tissue
    H. Akkaya
    Journal of Evolutionary Biochemistry and Physiology.2021; 57(2): 270.     CrossRef
  • Gametogenic and steroidogenic action of kisspeptin-10 in the Asian catfish, Clarias batrachus: Putative underlying mechanistic cascade
    Ankur Singh, Bechan Lal, Jyoti Parkash, Robert P. Millar
    Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology.2021; 256: 110642.     CrossRef
  • Dopamine D2 Receptor Antagonist Alters the Testosterone Release and Kisspeptin/GPR54 Signaling in Food-Restricted Rats
    Khatereh Nourmohammadi, Farrin Babaei-Balderlou, Seyyed Meysam Abtahi-Foroushani
    Iranian Journal of Science and Technology, Transactions A: Science.2021; 45(6): 1879.     CrossRef
  • Expression of reproductive‐related genes and changes in oocyte maturation of goldfish broodstock (Carassius auratus) following injection of different exogenous kisspeptins
    AbdolMajid Valipour, Behrooz Heidari, Hamidreza Vaziri, S. Mohsen Asghari
    Reproduction in Domestic Animals.2021; 56(10): 1349.     CrossRef
  • Seasonal expression and distribution of kisspeptin1 (kiss1) in the ovary and testis of freshwater catfish, Clarias batrachus: A putative role in steroidogenesis
    Ankur Singh, Bechan Lal, Ishwar S. Parhar, Robert P. Millar
    Acta Histochemica.2021; 123(6): 151766.     CrossRef
  • Benzo[a]pyrene impairs the migratory pattern of human gonadotropin-releasing-hormone-secreting neuroblasts
    Giulia Guarnieri, Matteo Becatti, Paolo Comeglio, Linda Vignozzi, Mario Maggi, Gabriella Barbara Vannelli, Annamaria Morelli
    European Journal of Histochemistry.2021;[Epub]     CrossRef
  • Bu-Shen-Zhu-Yun decoction induces PRLR deubiquitination and JAK2/STAT5 activation via CSN5 in vitro
    Hua Feng, Huifang Zhou, Jianxia Lu, Qing Zhang, Xingran Tang, Yujie Shang
    Aging.2021; 13(16): 20418.     CrossRef
  • Endocrinopathies and Male Infertility
    Pallav Sengupta, Sulagna Dutta, Ivan Rolland Karkada, Suresh V. Chinni
    Life.2021; 12(1): 10.     CrossRef
  • The Correlation between Hormonal Disturbance in PCOS Women and Serum Level of Kisspeptin
    Razaw O. Ibrahim, Shirwan H. Omer, Chro N. Fattah
    International Journal of Endocrinology.2020; 2020: 1.     CrossRef
  • Investigating the kisspeptin system in the hermaphrodite teleost gilthead seabream (Sparus aurata)
    Catarina C.V. Oliveira, Elsbeth McStay, Elsa Cabrita, Maria Filipa Castanheira, Hervé Migaud, Maria Teresa Dinis, Andrew Davie
    Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology.2020; 241: 110624.     CrossRef
  • Maternal plasma kisspeptin‐10 level in preeclamptic pregnant women and its relation in changing their reproductive hormones
    Maysoun A. Al‐Kaabi, Farqad B. Hamdan, Hisham Al‐Matubsi
    Journal of Obstetrics and Gynaecology Research.2020; 46(4): 575.     CrossRef
  • The potential therapeutic effects of Lactobacillus plantarum and inulin on serum and testicular reproductive markers in diabetic male rats
    Marziyeh Rahimiyan-Heravan, Leila Roshangar, Pouran Karimi, Safa Sefidgari-Abrasi, Mohammad Morshedi, Maryam Saghafi-Asl, Khadijeh Bavafa-Valenlia
    Diabetology & Metabolic Syndrome.2020;[Epub]     CrossRef
  • Lifestyle, metabolic disorders and male hypogonadism – A one-way ticket?
    Luís Crisóstomo, Sara C. Pereira, Mariana P. Monteiro, João F. Raposo, Pedro F. Oliveira, Marco G. Alves
    Molecular and Cellular Endocrinology.2020; 516: 110945.     CrossRef
  • Female infertility is associated with an altered expression of the neurokinin B/neurokinin B receptor and kisspeptin/kisspeptin receptor systems in ovarian granulosa and cumulus cells
    Victor Blasco, Francisco M. Pinto, Ainhoa Fernández-Atucha, Cristina González-Ravina, Manuel Fernández-Sánchez, Luz Candenas
    Fertility and Sterility.2020; 114(4): 869.     CrossRef
  • Cafeteria diet-induced obesity reduces leptin-stimulated NADPH-diaphorase reactivity in the hypothalamic arcuate nucleus of rats
    Milen Hristov, Boycho Landzhov, Krassimira Yakimova
    Acta Histochemica.2020; 122(7): 151616.     CrossRef
  • Potential Cardiovascular and Metabolic Beneficial Effects of ω-3 PUFA in Male Obesity Secondary Hypogonadism Syndrome
    Annalisa Noce, Giulia Marrone, Francesca Di Daniele, Manuela Di Lauro, Anna Pietroboni Zaitseva, Georgia Wilson Jones, Antonino De Lorenzo, Nicola Di Daniele
    Nutrients.2020; 12(9): 2519.     CrossRef
  • Peripheral action of kisspeptin at reproductive tissues—role in ovarian function and embryo implantation and relevance to assisted reproductive technology in livestock: a review
    Michael J D’Occhio, Giuseppe Campanile, Pietro S Baruselli
    Biology of Reproduction.2020; 103(6): 1157.     CrossRef
  • Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring
    Vicente Mustieles, Shereen Cynthia D'Cruz, Stephan Couderq, Andrea Rodríguez-Carrillo, Jean-Baptiste Fini, Tim Hofer, Inger-Lise Steffensen, Hubert Dirven, Robert Barouki, Nicolás Olea, Mariana F. Fernández, Arthur David
    Environment International.2020; 144: 105811.     CrossRef
  • Neonatal exposure to genistein affects reproductive physiology and behavior in female and male Long-Evans rats
    Maryam Ali, Timothy Michael Broyles, Lourdes K. Davis, Chantal M.F. Gonzalez, Devon Lucero, Lainey Stary, Fay A. Guarraci
    Behavioural Pharmacology.2020; 31(7): 610.     CrossRef
  • The LH/FSH ratio is not a sex-dimorphic marker after infancy: data from 6417 healthy individuals and 125 patients with Differences of Sex Development
    Marie L Ljubicic, Kirstine Jespersen, Lise Aksglaede, Casper P Hagen, Jørgen H Petersen, Helle R Andersen, Allan Linneberg, Katharina M Main, Anna-Maria Andersson, Trine H Johannsen, Anders Juul
    Human Reproduction.2020; 35(10): 2323.     CrossRef
  • Kisspeptin Influences the Reproductive Axis and Circulating Levels of microRNAs in Senegalese Sole
    Catarina C. V. Oliveira, Elvira Fatsini, Ignacio Fernández, Catarina Anjos, François Chauvigné, Joan Cerdà, Robin Mjelle, Jorge M. O. Fernandes, Elsa Cabrita
    International Journal of Molecular Sciences.2020; 21(23): 9051.     CrossRef
  • Effects of sevoflurane on reproductive function of male rats and its main mechanism of action
    Yanhong Cui, Jingying Liu, Yulin Zhu, Kun Xie, Jingui Yu, Lingzhi Yu, Yanhao Wang
    Inhalation Toxicology.2019; 31(11-12): 392.     CrossRef
  • Male Obesity-related Secondary Hypogonadism – Pathophysiology, Clinical Implications and Management
    Cornelius J Fernandez, Elias C Chacko, Joseph M Pappachan
    European Endocrinology.2019; 15(2): 83.     CrossRef
  • Perturbation of Nuclear Hormone Receptors by Endocrine Disrupting Chemicals: Mechanisms and Pathological Consequences of Exposure
    Julie M. Hall, Callie W. Greco
    Cells.2019; 9(1): 13.     CrossRef
  • Duplications in 19p13.3 are associated with male infertility
    Vertika Singh, Renu Bala, Arijit Chakraborty, Singh Rajender, Sameer Trivedi, Kiran Singh
    Journal of Assisted Reproduction and Genetics.2019; 36(10): 2171.     CrossRef
  • The Chronic and Unpredictable Stress Suppressed Kisspeptin Expression during Ovarian Cycle in Mice
    Seung-Joon Kim
    Journal of Animal Reproduciton and Biotechnology.2019; 34(1): 40.     CrossRef
  • KiSS1 in regulation of metastasis and response to antitumor drugs
    Cristina Corno, Paola Perego
    Drug Resistance Updates.2019; 42: 12.     CrossRef
  • Kisspeptin and attributes of infertile males and females: A cross‐sectional study in a subset of Pakistani population
    Rehana Rehman, Syeda S. Fatima, Faiza Alam, Mussarat Ashraf, Shaheen Zafar
    Andrologia.2019;[Epub]     CrossRef
  • Puberty and the Evolution of Developmental Science
    Carol M. Worthman, Samantha Dockray, Kristine Marceau
    Journal of Research on Adolescence.2019; 29(1): 9.     CrossRef
  • Kisspeptin/Neurokinin B/Dynorphin (KNDy) cells as integrators of diverse internal and external cues: evidence from viral-based monosynaptic tract-tracing in mice
    Aleisha M. Moore, Lique M. Coolen, Michael N. Lehman
    Scientific Reports.2019;[Epub]     CrossRef
  • Region-specific changes in brain kisspeptin receptor expression during estrogen depletion and the estrous cycle
    Saeko Ozaki, Shimpei Higo, Kinuyo Iwata, Hidehisa Saeki, Hitoshi Ozawa
    Histochemistry and Cell Biology.2019; 152(1): 25.     CrossRef
  • Minireview: The Epigenetic Modulation of KISS1 in Reproduction and Cancer
    Maria Letizia Motti, Rosaria Meccariello
    International Journal of Environmental Research and Public Health.2019; 16(14): 2607.     CrossRef
  • Altered expression of the kisspeptin/KISS1R and neurokinin B/NK3R systems in mural granulosa and cumulus cells of patients with polycystic ovarian syndrome
    Victor Blasco, Francisco M. Pinto, Ainhoa Fernández-Atucha, Nicolás Prados, Manuel Tena-Sempere, Manuel Fernández-Sánchez, Luz Candenas
    Journal of Assisted Reproduction and Genetics.2019; 36(1): 113.     CrossRef
  • Non hormonal management options for menstrual cycle irregularities
    I. V. Kuznetsova
    Medical Council.2019; (13): 16.     CrossRef
  • New markers for the detection of polycystic ovary syndrome
    Elham Sharif
    Obstetrics & Gynecology International Journal.2019;[Epub]     CrossRef
  • Antisense techniques provide robust decrease in GnRH receptor expression with minimal cytotoxicity in GT1-7 cells
    Maurice Andre Recanati, Hongling Du, Katherine J. Kramer, Maik Hüttemann, Robert A. Welch
    Systems Biology in Reproductive Medicine.2018; 64(5): 389.     CrossRef
  • Additive effect of simultaneous continuous administration of degarelix and TAK-448 on LH suppression in a castrated rat model
    Jacek Stalewski, Diane M. Hargrove, Monica Wolfe, Trudy A. Kohout, Adeela Kamal
    European Journal of Pharmacology.2018; 824: 24.     CrossRef
  • Various responses of male pituitary–gonadal axis to different intensities of long-term exercise: Role of expression of KNDY-related genes
    Nazli Khajehnasiri, Homayoun Khazali, Farzam Sheikhzadeh
    Journal of Biosciences.2018; 43(4): 569.     CrossRef
  • The role of neuropeptides and neurotransmitters on kisspeptin/kiss1r-signaling in female reproduction
    Saman Saedi, Arezoo Khoradmehr, Jafarzadeh Shirazi Mohammad Reza, Amin Tamadon
    Journal of Chemical Neuroanatomy.2018; 92: 71.     CrossRef
  • Neuropeptidome of the Hypothalamus and Pituitary Gland of Indicine × Taurine Heifers: Evidence of Differential Neuropeptide Processing in the Pituitary Gland before and after Puberty
    Kasey L. DeAtley, Michelle L. Colgrave, Angela Cánovas, Gene Wijffels, Ryan L. Ashley, Gail A. Silver, Gonzalo Rincon, Juan F. Medrano, Alma Islas-Trejo, Marina R. S. Fortes, Antonio Reverter, Laercio Porto-Neto, Sigrid A. Lehnert, Milton G. Thomas
    Journal of Proteome Research.2018; 17(5): 1852.     CrossRef
  • Kisspeptin as a new serum biomarker to discriminate miscarriage from viable intrauterine pregnancy
    Chantae Sullivan-Pyke, Daniel J. Haisenleder, Suneeta Senapati, Olivia Nicolais, Esther Eisenberg, Mary D. Sammel, Kurt T. Barnhart
    Fertility and Sterility.2018; 109(1): 137.     CrossRef
  • Thalamic integration of social stimuli regulating parental behavior and the oxytocin system
    Arpad Dobolyi, Melinda Cservenák, Larry J. Young
    Frontiers in Neuroendocrinology.2018; 51: 102.     CrossRef
  • Aging and estradiol effects on gene expression in the medial preoptic area, bed nucleus of the stria terminalis, and posterodorsal medial amygdala of male rats
    Victoria L. Nutsch, Margaret R. Bell, Ryan G. Will, Weiling Yin, Andrew Wolfe, Ross Gillette, Juan M. Dominguez, Andrea C. Gore
    Molecular and Cellular Endocrinology.2017; 442: 153.     CrossRef
  • Naloxegol, an opioid antagonist with reduced CNS penetration: Mode-of-action and human relevance for rat testicular tumours
    Håkan Andersson, Terri Mitchard, Nakpangi Johnson, Eike Floettmann
    Toxicology and Applied Pharmacology.2017; 329: 85.     CrossRef
  • The Role of Kisspeptin in Female Reproduction
    Sareh Zeydabadi Nejad, Fahimeh Ramezani Tehrani, Azita Zadeh-Vakili
    International Journal of Endocrinology and Metabolism.2017;[Epub]     CrossRef
  • The impact of postnatal leuprolide acetate treatment on reproductive characteristics in a rodent model of polycystic ovary syndrome
    Lady Katerine Serrano Mujica, Kalyne Bertolin, Alessandra Bridi, Werner Giehl Glanzner, Vitor Braga Rissi, Flávia de los Santos de Camargo, Renato Zanella, Osmar Damian Prestes, Rafael Noal Moresco, Alfredo Quites Antoniazzi, Paulo Bayard Dias Gonçalves,
    Molecular and Cellular Endocrinology.2017; 442: 125.     CrossRef
  • GLP-1 increases Kiss-1 mRNA expression in kisspeptin-expressing neuronal cells†
    Aki Oride, Haruhiko Kanasaki, Tselmeg Mijiddorj, Unurjargal Sukhbaatar, Tomomi Hara, Tuvshintugs Tumurbaatar, Satoru Kyo
    Biology of Reproduction.2017; 97(2): 240.     CrossRef
  • Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells
    Ariel Poliandri, Duncan Miller, Sasha Howard, Muriel Nobles, Gerard Ruiz-Babot, Stephen Harmer, Andrew Tinker, Tristan McKay, Leonardo Guasti, Leo Dunkel
    Molecular and Cellular Endocrinology.2017; 447: 12.     CrossRef
  • How is GnRH regulated in GnRH-producing neurons? Studies using GT1-7 cells as a GnRH-producing cell model
    Haruhiko Kanasaki, Aki Oride, Tselmeg Mijiddorj, Unurjargal Sukhbaatar, Satoru Kyo
    General and Comparative Endocrinology.2017; 247: 138.     CrossRef
  • Obesity, male infertility, and the sperm epigenome
    James R. Craig, Timothy G. Jenkins, Douglas T. Carrell, James M. Hotaling
    Fertility and Sterility.2017; 107(4): 848.     CrossRef
  • Seasonal infertility in gilts and sows: Aetiology, clinical implications and treatments
    Fabio De Rensis, Adam J. Ziecik, Roy N. Kirkwood
    Theriogenology.2017; 96: 111.     CrossRef
  • Ovulation, A Sign of Health
    Pilar Vigil, Carolina Lyon, Betsi Flores, Hernán Rioseco, Felipe Serrano
    The Linacre Quarterly.2017; 84(4): 343.     CrossRef
  • Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock response
    Antônio Azambuja Miragem, Paulo Ivo Homem de Bittencourt
    Human Reproduction Update.2017; 23(5): 600.     CrossRef
  • Kisspeptin as a promising oocyte maturation trigger for in vitro fertilisation in humans
    Miro Kasum, Daniela Franulić, Ermin Čehić, Slavko Orešković, Albert Lila, Emina Ejubović
    Gynecological Endocrinology.2017; 33(8): 583.     CrossRef
  • Molecular cloning and characterization of kiss1 in Brandt's voles ( Lasiopodomys brandtii )
    Yan Chen, Lan Liu, Zhengguang Li, Dawei Wang, Ning Li, Ying Song, Cong Guo, Xiaohui Liu
    Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology.2017; 208-209: 68.     CrossRef
  • Loss of the Habenula Intrinsic Neuromodulator Kisspeptin1 Affects Learning in Larval Zebrafish
    Charlotte Lupton, Mohini Sengupta, Ruey-Kuang Cheng, Joanne Chia, Vatsala Thirumalai, Suresh Jesuthasan
    eneuro.2017; 4(3): ENEURO.0326-16.2017.     CrossRef
  • Correlation of Kisspeptin-10 level and fetal well-being in preeclamptic patients
    Maysoun A. Ziyaraa, Farqad B. Hamdan, Liqaa R. Mousa
    Taiwanese Journal of Obstetrics and Gynecology.2016; 55(6): 840.     CrossRef
  • Neuropeptide derivatives to regulate the reproductive axis: Kisspeptin receptor (KISS1R) ligands and neurokinin‐3 receptor (NK3R) ligands
    Shinya Oishi, Nobutaka Fujii
    Peptide Science.2016; 106(4): 588.     CrossRef
  • An update on the prevention of ovarian hyperstimulation syndrome
    Omar El Tokhy, Julia Kopeika, Tarek El-Toukhy
    Women's Health.2016; 12(5): 496.     CrossRef
  • Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells1
    Jordán García-Ortega, Francisco M. Pinto, Nicolás Prados, Aixa R. Bello, Teresa A. Almeida, Manuel Fernández-Sánchez, Luz Candenas
    Biology of Reproduction.2016;[Epub]     CrossRef
  • Kisspeptin Regulation of Neuronal Activity throughout the Central Nervous System
    Xinhuai Liu, Allan E. Herbison
    Endocrinology and Metabolism.2016; 31(2): 193.     CrossRef
  • RF-amide neuropeptides and their receptors in Mammals: Pharmacological properties, drug development and main physiological functions
    Raphaëlle Quillet, Safia Ayachi, Frédéric Bihel, Khadija Elhabazi, Brigitte Ilien, Frédéric Simonin
    Pharmacology & Therapeutics.2016; 160: 84.     CrossRef
  • Kisspeptin-mediated regulation of the morpho-functional state of the rat testicles under the effect of silver nanoparticles
    V. Kalinovskyi, A. Pustovalov, M. Dzerzhynskyi, G. Grodzyuk, N. Andriushina
    Bulletin of Taras Shevchenko National University of Kyiv. Series: Problems of Physiological Functions Regulation.2016; 20(1): 8.     CrossRef
  • Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin may alter LH release patterns by abolishing sex differences in GABA/glutamate cell number and modifying the transcriptome of the male anteroventral periventricular nucleus
    Javier Del Pino Sans, Kelsey J. Clements, Alexander Suvorov, Sudha Krishnan, Hillary L. Adams, Sandra L. Petersen
    Neuroscience.2016; 329: 239.     CrossRef
  • Control of puberty onset and fertility by gonadotropin-releasing hormone neurons
    Allan E. Herbison
    Nature Reviews Endocrinology.2016; 12(8): 452.     CrossRef
  • Patent Highlights June–July 2015
    Hermann AM Mucke
    Pharmaceutical Patent Analyst.2015; 4(6): 423.     CrossRef
Close layer
Obesity and Metabolism
Trends in the Diabetes Epidemic in Korea
Kyoung Hwa Ha, Dae Jung Kim
Endocrinol Metab. 2015;30(2):142-146.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.142
  • 4,676 View
  • 45 Download
  • 65 Web of Science
  • 77 Crossref
AbstractAbstract PDFPubReader   

Diabetes mellitus is a leading cause of mortality and increased disability-adjusted life years worldwide. In Korea, the prevalence of diabetes increased from 8.6% to 11.0% in 2001 to 2013 and the prevalence of adult obesity, which is the most important risk factor of diabetes, increased from 29.2% to 31.8% during the same period. There has been a dramatic increase in the number of obese Koreans with diabetes in recent decades and the prevalence of diabetes in people aged 40 years and older also increased in 2001 to 2013. Nevertheless, the mean age at the first diagnosis of diabetes was very similar for men in 2005 and 2013, while the mean age for women decreased slightly. There is an inverse linear relationship between body mass index and age at the diagnosis of diabetes among those who are newly diagnosed. Accordingly, the prevalence of diabetes is increasingly shifting to younger individuals and those who are obese. Therefore, public efforts should focus on healthy lifestyle changes, primary prevention measures, screening for the early detection of diabetes, and long-term management.

Citations

Citations to this article as recorded by  
  • Smoking behavior change and the risk of pneumonia hospitalization among smokers with diabetes mellitus
    Dong-Woo Han, Wonyoung Jung, Kyu Na Lee, Kyungdo Han, Sei Won Lee, Dong Wook Shin
    Scientific Reports.2023;[Epub]     CrossRef
  • Effects of Teneligliptin on HbA1c levels, Continuous Glucose Monitoring-Derived Time in Range and Glycemic Variability in Elderly Patients with T2DM (TEDDY Study)
    Ji Cheol Bae, Soo Heon Kwak, Hyun Jin Kim, Sang-Yong Kim, You-Cheol Hwang, Sunghwan Suh, Bok Jin Hyun, Ji Eun Cha, Jong Chul Won, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2022; 46(1): 81.     CrossRef
  • Rising Incidence of Diabetes in Young Adults in South Korea: A National Cohort Study
    Hyun Ho Choi, Giwoong Choi, Hojun Yoon, Kyoung Hwa Ha, Dae Jung Kim
    Diabetes & Metabolism Journal.2022; 46(5): 803.     CrossRef
  • Differences in health behavior and nutrient intake status between diabetes-aware and unaware Korean adults based on the Korea national health and nutrition examination survey 2016–18 data: A cross-sectional study
    Anshul Sharma, Chen Lulu, Kee-Ho Song, Hae-Jeung Lee
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Triglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort
    Byoungjin Park, Hye Sun Lee, Yong-Jae Lee
    Translational Research.2021; 228: 42.     CrossRef
  • Did Sejong the Great have ankylosing spondylitis? The oldest documented case of ankylosing spondylitis
    JiHwan Lee
    International Journal of Rheumatic Diseases.2021; 24(2): 203.     CrossRef
  • Diabetes Fact Sheets in Korea, 2020: An Appraisal of Current Status
    Chan-Hee Jung, Jang Won Son, Shinae Kang, Won Jun Kim, Hun-Sung Kim, Hae Soon Kim, Mihae Seo, Hye-Jung Shin, Seong-Su Lee, Su Jin Jeong, Yongin Cho, Seung Jin Han, Hyang Mi Jang, Mira Rho, Shinbi Lee, Mihyun Koo, Been Yoo, Jung-Wha Moon, Hye Young Lee, Ja
    Diabetes & Metabolism Journal.2021; 45(1): 1.     CrossRef
  • Association between living alone and incident type 2 diabetes among middle-aged individuals in Korea: a nationwide cohort study
    Ga Eun Nam, Wonsock Kim, Kyungdo Han, Jin-Hyung Jung, Byoungduck Han, Jinwook Kim, Nan Hee Kim, Kyung Mook Choi, Kyung Hwan Cho, Yong Gyu Park, Seon Mee Kim
    Scientific Reports.2021;[Epub]     CrossRef
  • White Blood Cell Count as a Predictor of Incident Type 2 Diabetes Mellitus Among Non-Obese Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study
    Jae-Min Park, Hye Sun Lee, Ju-Young Park, Dong-Hyuk Jung, Ji-Won Lee
    Journal of Inflammation Research.2021; Volume 14: 1235.     CrossRef
  • A 9-Year Comparison of Dementia Prevalence in Korea: Results of NaSDEK 2008 and 2017
    Seung Wan Suh, You Joung Kim, Kyung Phil Kwak, Kiwon Kim, Moon-Doo Kim, Byung-Soo Kim, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hui Kim, Seok Woo Moon, Kyung Won Park, Jong-Il Park, Joon Hyuk Park, Jae Nam Bae, Jiyeong Seo, Su Jeong Seong, Sang Joo
    Journal of Alzheimer's Disease.2021; 81(2): 821.     CrossRef
  • Trends of Diabetes and Prediabetes Prevalence among Korean Adolescents From 2007 to 2018
    Ji Hyun Kim, Jung Sub Lim
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Breast Cancer Statistics in Korea, 2018
    Sang Yull Kang, Sae Byul Lee, Yoo Seok Kim, Zisun Kim, Hyun Yul Kim, Hee Jeong Kim, Sungmin Park, Soo Youn Bae, Kwanghyun Yoon, Se Kyung Lee, Kyu-Won Jung, Jaihong Han, Hyun Jo Youn
    Journal of Breast Cancer.2021; 24(2): 123.     CrossRef
  • Longitudinal Changes in Clinical Features, Management, and Outcomes of Idiopathic Pulmonary Fibrosis. A Nationwide Cohort Study
    Sung Woo Moon, Song Yee Kim, Man Pyo Chung, Hongseok Yoo, Sung Hwan Jeong, Dong Soon Kim, Jin Woo Song, Hong Lyeol Lee, Sun Mi Choi, Young Whan Kim, Yong Hyun Kim, Choon-Sik Park, Sung-Woo Park, Jong Sun Park, Yangjin Jegal, Jongmin Lee, Soo-Taek Uh, Tae-
    Annals of the American Thoracic Society.2021; 18(5): 780.     CrossRef
  • Association between Inflammatory Markers and Glycemic Control in Korean Diabetic Patients
    Min Kang, Seok-Joon Sohn
    Journal of Health Informatics and Statistics.2021; 46(3): 247.     CrossRef
  • Associations between obesity, weight change and decreased renal function in Korean type 2 diabetic patients: a longitudinal follow-up study
    Bo-Yeon Kim, Dug-Hyun Choi, Chan-Hee Jung, Ji-Oh Mok, Chul-Hee Kim
    BMC Endocrine Disorders.2021;[Epub]     CrossRef
  • Role of Estrogen in Type 1 and Type 2 Diabetes Mellitus: A Review of Clinical and Preclinical Data
    Monica De Paoli, Geoff H. Werstuck
    Canadian Journal of Diabetes.2020; 44(5): 448.     CrossRef
  • Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea
    Suk Kyeong Kim, Ju-Young Jang, Dong-Lim Kim, Young A Rhyu, Suh Eun Lee, Seung-Hyun Ko, Kyungdo Han, Kee-Ho Song
    The Korean Journal of Internal Medicine.2020; 35(3): 641.     CrossRef
  • Alteration of Microbiome Profile by D-Allulose in Amelioration of High-Fat-Diet-Induced Obesity in Mice
    Youngji Han, Haryung Park, Bo-Ra Choi, Yosep Ji, Eun-Young Kwon, Myung-Sook Choi
    Nutrients.2020; 12(2): 352.     CrossRef
  • Type 2 diabetes: epidemiological changes at Instituto Mexicano del Seguro Social—associated with complications in Mexico
    Jessie N. Zurita-Cruz, Leticia Manuel-Apolinar, María Luisa Arellano-Flores, Alejandro Gutierrez-Gonzalez, Aleida de Jesús Rivera-Hernández, Rosa Angélica Carranza-Muleiro, Víctor Hugo Borja-Aburto, Nelly Cisneros-González
    International Journal of Diabetes in Developing Countries.2020; 40(2): 178.     CrossRef
  • Effects of Particulate Respirator Use on Cardiopulmonary Function in Elderly Women: a Quasi-Experimental Study
    Youn-Hee Lim, Woosung Kim, Yumi Choi, Hwan-Cheol Kim, Geunjoo Na, Hyoung-Ryoul Kim, Yun-Chul Hong
    Journal of Korean Medical Science.2020;[Epub]     CrossRef
  • GLP‑1 receptor agonist on cardiovascular complications of diabetes mellitus
    Fengjun Liu, Yanhua Kong
    Experimental and Therapeutic Medicine.2020;[Epub]     CrossRef
  • Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity
    Seung-Soon Im, Hyeon Young Park, Jong Cheol Shon, In-Sung Chung, Ho Chan Cho, Kwang-Hyeon Liu, Dae-Kyu Song, Kyoung Heon Kim
    PLOS ONE.2019; 14(3): e0213285.     CrossRef
  • Diabetes Fact Sheets in Korea, 2018: An Appraisal of Current Status
    Bo-Yeon Kim, Jong Chul Won, Jae Hyuk Lee, Hun-Sung Kim, Jung Hwan Park, Kyoung Hwa Ha, Kyu Chang Won, Dae Jung Kim, Kyong Soo Park
    Diabetes & Metabolism Journal.2019; 43(4): 487.     CrossRef
  • Analysis of diabetes quality assessment findings and future directions for the appropriate management of diabetes in Korea
    Yu Jin Kim, Suk Chon, Seungjoon Oh, Jeong-taek Woo, Sung Woon Kim, Sang Youl Rhee
    The Korean Journal of Internal Medicine.2019; 34(1): 125.     CrossRef
  • Diabetes and the Risk of Infection: A National Cohort Study
    Eun Jin Kim, Kyoung Hwa Ha, Dae Jung Kim, Young Hwa Choi
    Diabetes & Metabolism Journal.2019; 43(6): 804.     CrossRef
  • Age-specific diabetes risk by the number of metabolic syndrome components: a Korean nationwide cohort study
    Min-Kyung Lee, Kyungdo Han, Hyuk-Sang Kwon
    Diabetology & Metabolic Syndrome.2019;[Epub]     CrossRef
  • Changes in real-life practice for hepatocellular carcinoma patients in the Republic of Korea over a 12-year period: A nationwide random sample study
    Beom Kyung Kim, Do Young Kim, Kwang-Hyub Han, Jinsil Seong, Jung Weon Lee
    PLOS ONE.2019; 14(10): e0223678.     CrossRef
  • Association between continuity of care and type 2 diabetes development among patients with thyroid disorder
    Sang Ah Lee, Dong-Woo Choi, Junhyun Kwon, Doo Woong Lee, Eun-Cheol Park
    Medicine.2019; 98(52): e18537.     CrossRef
  • Association of C-Reactive Protein with Risk of Developing Type 2 Diabetes Mellitus, and Role of Obesity and Hypertension: A Large Population-Based Korean Cohort Study
    Suganya Kanmani, Minji Kwon, Moon-Kyung Shin, Mi Kyung Kim
    Scientific Reports.2019;[Epub]     CrossRef
  • Egg consumption is associated with a lower risk of type 2 diabetes in middle-aged and older men
    Jieul Lee, Jihye Kim
    Nutrition Research and Practice.2018; 12(5): 396.     CrossRef
  • Diabetes, Frequency of Exercise, and Mortality Over 12 Years: Analysis of the National Health Insurance Service-Health Screening (NHIS-HEALS) Database
    Woo Young Shin, Taehee Lee, Da-Hye Jeon, Hyeon Chang Kim
    Journal of Korean Medical Science.2018;[Epub]     CrossRef
  • Epidemiology of liver cancer in South Korea
    Bo Hyun Kim, Joong-Won Park
    Clinical and Molecular Hepatology.2018; 24(1): 1.     CrossRef
  • Letter: Clinical Characteristics of People with Newly Diagnosed Type 2 Diabetes between 2015 and 2016: Difference by Age and Body Mass Index (Diabetes Metab J 2018;42:137-46)
    Ah Reum Khang
    Diabetes & Metabolism Journal.2018; 42(3): 249.     CrossRef
  • Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo-controlled clinical trial
    Han Seok Choi, Sunmi Kim, Min Jung Kim, Myung-Sunny Kim, Juewon Kim, Chan-Woong Park, Daebang Seo, Song Seok Shin, Sang Woo Oh
    Journal of Ginseng Research.2018; 42(1): 90.     CrossRef
  • Response: Clinical Characteristics of People with Newly Diagnosed Type 2 Diabetes between 2015 and 2016: Difference by Age and Body Mass Index (Diabetes Metab J2018;42:137-46)
    Kyoung Hwa Ha, Dae Jung Kim, Sungrae Kim
    Diabetes & Metabolism Journal.2018; 42(3): 251.     CrossRef
  • Prediction of Type 2 Diabetes Remission after Bariatric or Metabolic Surgery
    Ji Yeon Park
    Journal of Obesity & Metabolic Syndrome.2018; 27(4): 213.     CrossRef
  • Waist‐to‐calf circumstance ratio is an independent predictor of hepatic steatosis and fibrosis in patients with type 2 diabetes
    Eun Yeong Choe, Yong‐ho Lee, Young Ju Choi, Byung Wook Huh, Byung‐Wan Lee, Soo‐Kyung Kim, Eun Seok Kang, Bong‐Soo Cha, Eun Jig Lee, Kap Bum Huh, Zobair M Younossi
    Journal of Gastroenterology and Hepatology.2018; 33(5): 1082.     CrossRef
  • Prevalence of Comorbidities among Patients with Diabetes
    Suyoung Kim, Eun-Hee Nah, Seon Cho
    Journal of Health Informatics and Statistics.2018; 43(3): 237.     CrossRef
  • Risk of new-onset diabetes among patients treated with statins according to hypertension and gender: Results from a nationwide health-screening cohort
    Sang-Eun Lee, Ji Min Sung, In-Jeong Cho, Hyeon Chang Kim, Hyuk-Jae Chang, Lamberto Manzoli
    PLOS ONE.2018; 13(4): e0195459.     CrossRef
  • Outcomes of living donor kidney transplantation in diabetic patients: age and sex matched comparison with non-diabetic patients
    Chung Hee Baek, Hyosang Kim, Seung Don Baek, Mun Jang, Wonhak Kim, Won Seok Yang, Duck Jong Han, Su-Kil Park
    The Korean Journal of Internal Medicine.2018; 33(2): 356.     CrossRef
  • An Analysis of The Morbidity and Mortality of Diabetes Mellitus in a Forensic Context
    Chong Zhou, Roger W. Byard
    Journal of Forensic Sciences.2018; 63(4): 1149.     CrossRef
  • Favorable glycemic response after pancreatoduodenectomy in both patients with pancreatic cancer and patients with non-pancreatic cancer
    Seo Young Sohn, Eun Kyung Lee, Sung-Sik Han, You Jin Lee, Yul Hwangbo, Young Hwa Kang, Seung Duk Lee, Seong Hoon Kim, Sang Myung Woo, Woo Jin Lee, Eun Kyung Hong, Sang-Jae Park
    Medicine.2018; 97(18): e0590.     CrossRef
  • Comparison of Open and Laparoscopic Gastrectomy in Elderly Patients
    Su Mi Kim, Ho Geun Youn, Ji Yeong An, Yoon Young Choi, Sung Hoon Noh, Seung Jong Oh, Tae Sung Sohn, Sung Kim
    Journal of Gastrointestinal Surgery.2018; 22(5): 785.     CrossRef
  • Development and Validation of the Korean Diabetes Risk Score: A 10-Year National Cohort Study
    Kyoung Hwa Ha, Yong-ho Lee, Sun Ok Song, Jae-woo Lee, Dong Wook Kim, Kyung-hee Cho, Dae Jung Kim
    Diabetes & Metabolism Journal.2018; 42(5): 402.     CrossRef
  • Trends in diabetes prevalence among Korean adults based on Korean National Health and Nutrition Examination Surveys III–VI
    Jae-woo Lee, Hee-Taik Kang, Hyoung-Ji Lim, Byoungjin Park
    Diabetes Research and Clinical Practice.2018; 138: 57.     CrossRef
  • Clinical Characteristics of People with Newly Diagnosed Type 2 Diabetes between 2015 and 2016: Difference by Age and Body Mass Index
    Kyoung Hwa Ha, Cheol Young Park, In Kyung Jeong, Hyun Jin Kim, Sang-Yong Kim, Won Jun Kim, Ji Sung Yoon, In Joo Kim, Dae Jung Kim, Sungrae Kim
    Diabetes & Metabolism Journal.2018; 42(2): 137.     CrossRef
  • Nonalcoholic fatty liver disease-associated hepatocellular carcinoma in a hepatitis B virus-endemic area
    Chang Hwi Yoon, Young-Joo Jin, Jin Woo Lee
    European Journal of Gastroenterology & Hepatology.2018; 30(9): 1090.     CrossRef
  • Prediction of Diabetes Remission after Bariatric or Metabolic Surgery
    Ji Yeon Park
    Journal of Metabolic and Bariatric Surgery.2018; 7(1): 22.     CrossRef
  • Incidence and predictors of type 2 diabetes among Koreans: A 12-year follow up of the Korean Genome and Epidemiology Study
    Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Kwan Woo Lee, Nam H. Cho
    Diabetes Research and Clinical Practice.2017; 123: 173.     CrossRef
  • Glycated Hemoglobin and All-Cause Mortality in Korean Type 2 Diabetes
    Mi Suk An, Sun A Kim, Jun-Ho Lee, Seong-Woo Choi, Min-Ho Shin
    Chonnam Medical Journal.2017; 53(3): 223.     CrossRef
  • Analysis and comparison of the cost-effectiveness of statins according to the baseline low-density lipoprotein cholesterol level in Korea
    Y. J. Jeong, H. Kim, S. J. Baik, T. M. Kim, S. J. Yang, S.-H. Lee, J.-H. Cho, H. Lee, H. W. Yim, I. Y. Choi, K.-H. Yoon, H.-S. Kim
    Journal of Clinical Pharmacy and Therapeutics.2017; 42(3): 292.     CrossRef
  • Governmental or Social Support of Bariatric Surgery in the Asia-Pacific Region
    Jisun Lim, Young Hye Cho, Hiroshi Yamamoto, Alvin Eng, Tania Markovic, Kyoung Kon Kim
    Journal of Obesity & Metabolic Syndrome.2017; 26(1): 10.     CrossRef
  • Application of the 2013 American College of Cardiology/American Heart Association Cholesterol Guideline to the Korean National Health and Nutrition Examination Surveys from 1998 to 2012
    Young Shin Song, Tae Jung Oh, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang, Kyong Soo Park, Soo Lim
    Diabetes & Metabolism Journal.2017; 41(1): 38.     CrossRef
  • The differences in the incidence of diabetes mellitus and prediabetes according to the type of HMG-CoA reductase inhibitors prescribed in Korean patients
    Tong Min Kim, Hyunah Kim, Yoo Jin Jeong, Sun Jung Baik, So Jung Yang, Seung-Hwan Lee, Jae-Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun-Ho Yoon, Hun-Sung Kim
    Pharmacoepidemiology and Drug Safety.2017; 26(10): 1156.     CrossRef
  • The Effect and Safety of Dapagliflozin in Patients with Type 2 Diabetes: A Single-Institution Pharmacovigilance Review
    Hyung Woo Lee, Sun Joon Moon, Hee Sim Han, Eun Jeong Shin, Jin Hee Baek, Hyun-Joo Han, Young Min Cho, Kwi Suk Kim
    The Journal of Korean Diabetes.2017; 18(4): 275.     CrossRef
  • Optimal glycemic target level for colon cancer patients with diabetes
    Shin Jun Lee, Jae Hyun Kim, Seun Ja Park, So Young Ock, Su Kyoung Kwon, Young Sik Choi, Bu Kyung Kim
    Diabetes Research and Clinical Practice.2017; 124: 66.     CrossRef
  • Physician-Directed Diabetes Education without a Medication Change and Associated Patient Outcomes
    Hun-Sung Kim, Hyunah Kim, Hae-Kyung Yang, Eun Young Lee, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Seo Yeon Baik, Seung-Hwan Lee, Jae Hyoung Cho, In Young Choi, Hyeon Woo Yim, Bong-Yun Cha
    Diabetes & Metabolism Journal.2017; 41(3): 187.     CrossRef
  • Does Weight Gain Associated with Thiazolidinedione Use Negatively Affect Cardiometabolic Health?
    Ki Dong Ko, Kyoung Kon Kim, Kyu Rae Lee
    Journal of Obesity & Metabolic Syndrome.2017; 26(2): 102.     CrossRef
  • Clinical Characteristics and Outcome of Acute Heart Failure in Korea: Results from the Korean Acute Heart Failure Registry (KorAHF)
    Sang Eun Lee, Hae-Young Lee, Hyun-Jai Cho, Won-Seok Choe, Hokon Kim, Jin Oh Choi, Eun-Seok Jeon, Min-Seok Kim, Jae-Joong Kim, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Hyun-Young Park, Myeon
    Korean Circulation Journal.2017; 47(3): 341.     CrossRef
  • Factors that could explain the increasing prevalence of type 2 diabetes among adults in a Canadian province: a critical review and analysis
    Véronique Thibault, Mathieu Bélanger, Emilie LeBlanc, Lise Babin, Stuart Halpine, Beverly Greene, Michelina Mancuso
    Diabetology & Metabolic Syndrome.2016;[Epub]     CrossRef
  • Association of Waist-Height Ratio with Diabetes Risk: A 4-Year Longitudinal Retrospective Study
    Yoon Jeong Son, Jihyun Kim, Hye-Jeong Park, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
    Endocrinology and Metabolism.2016; 31(1): 127.     CrossRef
  • Social Networking Services-Based Communicative Care for Patients with Diabetes Mellitus in Korea
    Hun-Sung Kim, Yoo Jeong, Sun Baik, So Yang, Tong Kim, Hyunah Kim, Hyunyong Lee, Seung-Hwan Lee, Jae Cho, In-Young Choi, Kun-Ho Yoon
    Applied Clinical Informatics.2016; 07(03): 899.     CrossRef
  • Relative and combined effects of socioeconomic status and diabetes on mortality
    Nam Hoon Kim, Tae Joon Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Yousung Park, Sin Gon Kim
    Medicine.2016; 95(30): e4403.     CrossRef
  • Recent Advances in Diagnostic Strategies for Diabetic Peripheral Neuropathy
    Jong Chul Won, Tae Sun Park
    Endocrinology and Metabolism.2016; 31(2): 230.     CrossRef
  • Patterns of Diagnosis and Risk Factors for Type 2 Diabetes in Women with a History of Gestational Diabetes Mellitus
    Mi Jin Choi, Chae Weon Chung
    Perspectives in Nursing Science.2016; 13(1): 17.     CrossRef
  • Mortality and causes of death in a national sample of type 2 diabetic patients in Korea from 2002 to 2013
    Yu Mi Kang, Ye-Jee Kim, Joong-Yeol Park, Woo Je Lee, Chang Hee Jung
    Cardiovascular Diabetology.2016;[Epub]     CrossRef
  • Health Performance and Challenges in Korea: a Review of the Global Burden of Disease Study 2013
    Yo Han Lee, Seok-Jun Yoon, Arim Kim, Hyeyoung Seo, Seulki Ko
    Journal of Korean Medical Science.2016; 31(Suppl 2): S114.     CrossRef
  • Pharmacological Management of Obesity in Patients with Type 2 Diabetes: An Update
    Eun Ju Lee, Tae Nyun Kim
    The Korean Journal of Obesity.2016; 25(3): 121.     CrossRef
  • Current status of managing diabetes mellitus in Korea
    Kyoung Hwa Ha, Dae Jung Kim
    The Korean Journal of Internal Medicine.2016; 31(5): 845.     CrossRef
  • Hyperglycemia at presentation is associated with in hospital mortality in non-diabetic patient with organophosphate poisoning
    Jeong Mi Moon, Byeong Jo Chun, Yong Soo Cho
    Clinical Toxicology.2016; 54(3): 252.     CrossRef
  • Effectiveness of Web-Based Interventions for Managing Diabetes in Korea
    Jee Young Joo
    CIN: Computers, Informatics, Nursing.2016; 34(12): 587.     CrossRef
  • Hypoglycemia and Health Costs
    Yong-ho Lee, Gyuri Kim, Eun Seok Kang
    The Journal of Korean Diabetes.2016; 17(1): 11.     CrossRef
  • Letter: Characterization of Patients with Type 2 Diabetes according to Body Mass Index: Korea National Health and Nutrition Examination Survey from 2007 to 2011 (Endocrinol Metab 2015;30:514-21, Dong-Hwa Lee et al.)
    Eun-Hee Cho
    Endocrinology and Metabolism.2016; 31(2): 345.     CrossRef
  • Gender-Specific Associations between Socioeconomic Status and Psychological Factors and Metabolic Syndrome in the Korean Population: Findings from the 2013 Korean National Health and Nutrition Examination Survey
    Kyoung Im Cho, Bo Hyun Kim, Hyung Gon Je, Jae Sik Jang, Yong Hyun Park
    BioMed Research International.2016; 2016: 1.     CrossRef
  • Need for Diabetes Prevention Study
    Ja Young Jeon, Dae Jung Kim
    The Journal of Korean Diabetes.2015; 16(3): 161.     CrossRef
  • Diabetes in Asians
    Eun-Jung Rhee
    Endocrinology and Metabolism.2015; 30(3): 263.     CrossRef
  • Epidemiologic Characteristics of Dyslipidemia in Korea
    Kyoung Hwa Ha, Hyuk-Sang Kwon, Dae Jung Kim
    Journal of Lipid and Atherosclerosis.2015; 4(2): 93.     CrossRef
Close layer
Obesity and Metabolism
Genetic Studies on Diabetic Microvascular Complications: Focusing on Genome-Wide Association Studies
Soo Heon Kwak, Kyong Soo Park
Endocrinol Metab. 2015;30(2):147-158.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.147
  • 3,733 View
  • 37 Download
  • 14 Web of Science
  • 12 Crossref
AbstractAbstract PDFPubReader   

Diabetes is a common metabolic disorder with a worldwide prevalence of 8.3% and is the leading cause of visual loss, end-stage renal disease and amputation. Recently, genome-wide association studies (GWASs) have identified genetic risk factors for diabetic microvascular complications of retinopathy, nephropathy, and neuropathy. We summarized the recent findings of GWASs on diabetic microvascular complications and highlighted the challenges and our opinion on future directives. Five GWASs were conducted on diabetic retinopathy, nine on nephropathy, and one on neuropathic pain. The majority of recent GWASs were underpowered and heterogeneous in terms of study design, inclusion criteria and phenotype definition. Therefore, few reached the genome-wide significance threshold and the findings were inconsistent across the studies. Recent GWASs provided novel information on genetic risk factors and the possible pathophysiology of diabetic microvascular complications. However, further collaborative efforts to standardize phenotype definition and increase sample size are necessary for successful genetic studies on diabetic microvascular complications.

Citations

Citations to this article as recorded by  
  • Genetics of diabetes
    Shiwali Goyal, Jyoti Rani, Mohd Akbar Bhat, Vanita Vanita
    World Journal of Diabetes.2023; 14(6): 656.     CrossRef
  • Plasma thrombin-activatable fibrinolysis inhibitor and the 1040C/T polymorphism are risk factors for diabetic kidney disease in Chinese patients with type 2 diabetes
    Qinghua Huang, Dujin Feng, Lianlian Pan, Huan Wang, Yan Wu, Bin Zhong, Jianguang Gong, Huijun Lin, Xianming Fei
    PeerJ.2023; 11: e16352.     CrossRef
  • The G Allele of the rs12050217 Polymorphism in the BDKRB1 Gene Is Associated with Protection for Diabetic Retinopathy
    Leticia A. Brondani, Daisy Crispim, Julia Pisco, Jorge A. Guimarães, Markus Berger
    Current Eye Research.2019; 44(9): 994.     CrossRef
  • Genome‐wide association study identifies new susceptibility loci for diabetic nephropathy in Korean patients with type 2 diabetes mellitus
    Kyung H. Jeong, Jin S. Kim, Jeong‐Taek Woo, Sang Y. Rhee, Yu H. Lee, Yang G. Kim, Ju‐Young Moon, Su K. Kim, Sun W. Kang, Sang H. Lee, Yeong H. Kim
    Clinical Genetics.2019; 96(1): 35.     CrossRef
  • Diabetic polyneuropathy, deep white matter lesions, and carotid atherosclerosis: is there any association?
    Sevgi Ferik, Hayat Güven, Mehlika Panpallı Ateş, Işık Conkbayır, Selçuk Çomoğlu, Bülent Güven
    Neurological Sciences.2018; 39(1): 103.     CrossRef
  • Altered expression of WFS1 and NOTCH2 genes associated with diabetic nephropathy in T2DM patients
    Sahar A. Sharaf, Nagwa A. Kantoush, Dina F. Ayoub, Alshaymaa A. Ibrahim, Amaal A. Abdelaal, Rokaya Abdel Aziz, Mahmoud M. ElHefnawi, Amira N. Ahmed
    Diabetes Research and Clinical Practice.2018; 140: 304.     CrossRef
  • Precision medicine in diabetes prevention, classification and management
    Fangying Xie, Juliana CN Chan, Ronald CW Ma
    Journal of Diabetes Investigation.2018; 9(5): 998.     CrossRef
  • Clinical worthlessness of genetic prediction of common forms of diabetes mellitus and related chronic complications
    R. Buzzetti, S. Prudente, M. Copetti, M. Dauriz, S. Zampetti, M. Garofolo, G. Penno, V. Trischitta
    Nutrition, Metabolism and Cardiovascular Diseases.2017; 27(2): 99.     CrossRef
  • Diabetic macular oedema: clinical risk factors and emerging genetic influences
    Ebony Liu, Jamie E Craig, Kathryn Burdon
    Clinical and Experimental Optometry.2017; 100(6): 569.     CrossRef
  • Normoalbuminuric diabetic kidney disease
    Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun
    Frontiers of Medicine.2017; 11(3): 310.     CrossRef
  • Biomarkers of Diabetic Retinopathy
    Daniel Shu Wei Ting, Kara-Anne Tan, Val Phua, Gavin Siew Wei Tan, Chee Wai Wong, Tien Yin Wong
    Current Diabetes Reports.2016;[Epub]     CrossRef
  • Association Between Heme Oxygenase-1 Promoter Polymorphisms and the Development of Albuminuria in Type 2 Diabetes
    Eun Young Lee, Yong-ho Lee, Soo Hyun Kim, Kyu Sik Jung, Obin Kwon, Beom Seok Kim, Chung Mo Nam, Chun Sik Park, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Hyun Chul Lee
    Medicine.2015; 94(43): e1825.     CrossRef
Close layer
Obesity and Metabolism
New Directions in Chronic Disease Management
Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon
Endocrinol Metab. 2015;30(2):159-166.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.159
  • 4,316 View
  • 35 Download
  • 20 Web of Science
  • 23 Crossref
AbstractAbstract PDFPubReader   

A worldwide epidemic of chronic disease, and complications thereof, is underway, with no sign of abatement. Healthcare costs have increased tremendously, principally because of the need to treat chronic complications of non-communicable diseases including cardiovascular disease, blindness, end-stage renal disease, and amputation of extremities. Current healthcare systems fail to provide an appropriate quality of care to prevent the development of chronic complications without additional healthcare costs. A new paradigm for prevention and treatment of chronic disease and the complications thereof is urgently required. Several clinical studies have clearly shown that frequent communication between physicians and patients, based on electronic data transmission from medical devices, greatly assists in the management of chronic disease. However, for various reasons, these advantages have not translated effectively into real clinical practice. In the present review, we describe current relevant studies, and trends in the use of information technology for chronic disease management. We also discuss limitations and future directions.

Citations

Citations to this article as recorded by  
  • Change in coronary heart disease hospitalization after chronic disease management: a programme policy in China
    Jingmin Zhu, Wei Wang, Jun Wang, Liang Zhu
    Health Policy and Planning.2023; 38(2): 161.     CrossRef
  • Evaluating the effect of the COVID-19 pandemic on hypertension and diabetes care in South Korea: an interrupted time series analysis
    Boram Sim, Sunmi Kim, Eun Woo Nam
    BMC Public Health.2023;[Epub]     CrossRef
  • Towards Telemedicine Adoption in Korea: 10 Practical Recommendations for Physicians
    Hun-Sung Kim
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • A family nurse-led intervention for reducing health services’ utilization in individuals with chronic diseases: The ADVICE pilot study
    Serenella Savini, Paolo Iovino, Dario Monaco, Roberta Marchini, Tiziana Di Giovanni, Giuseppe Donato, Ausilia Pulimeno, Carmela Matera, Giuseppe Quintavalle, Carlo Turci
    International Journal of Nursing Sciences.2021; 8(3): 264.     CrossRef
  • Palmitoylethanolamide: A Natural Compound for Health Management
    Paul Clayton, Mariko Hill, Nathasha Bogoda, Silma Subah, Ruchitha Venkatesh
    International Journal of Molecular Sciences.2021; 22(10): 5305.     CrossRef
  • Lack of Acceptance of Digital Healthcare in the Medical Market: Addressing Old Problems Raised by Various Clinical Professionals and Developing Possible Solutions
    Jong Il Park, Hwa Young Lee, Hyunah Kim, Jisan Lee, Jiwon Shinn, Hun-Sung Kim
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Lessons from Temporary Telemedicine Initiated owing to Outbreak of COVID-19
    Hun-Sung Kim
    Healthcare Informatics Research.2020; 26(2): 159.     CrossRef
  • Using Goal-Directed Design to Create a Mobile Health App to Improve Patient Compliance With Hypertension Self-Management: Development and Deployment
    Huilong Duan, Zheyu Wang, Yumeng Ji, Li Ma, Fang Liu, Mingwei Chi, Ning Deng, Jiye An
    JMIR mHealth and uHealth.2020; 8(2): e14466.     CrossRef
  • Physical Activity for Prevention and Management of Sleep Disturbances
    Ah Reum Jung, Jong Il Park, Hun-Sung Kim
    Sleep Medicine Research.2020; 11(1): 15.     CrossRef
  • Lessons from Use of Continuous Glucose Monitoring Systems in Digital Healthcare
    Hun-Sung Kim, Kun-Ho Yoon
    Endocrinology and Metabolism.2020; 35(3): 541.     CrossRef
  • Recent Technology-Driven Advancements in Cardiovascular Disease Prevention in Korea
    Jisan Lee, Hun-Sung Kim, Dai-Jin Kim
    Cardiovascular Prevention and Pharmacotherapy.2019; 1(2): 43.     CrossRef
  • Telemedicine-Based Health Coaching Is Effective for Inducing Weight Loss and Improving Metabolic Markers
    Kelly E. Johnson, Michelle K. Alencar, Kathryn E. Coakley, Damon L. Swift, Nathan H. Cole, Christine M. Mermier, Len Kravitz, Fabiano T. Amorim, Ann L. Gibson
    Telemedicine and e-Health.2019; 25(2): 85.     CrossRef
  • Economical Mobile Healthcare and Wellness Application System
    Mahendra Kumar Jangir, Karan Singh, Vishnu Shankar
    SSRN Electronic Journal .2018;[Epub]     CrossRef
  • Technology for Remote Health Monitoring in an Older Population: A Role for Mobile Devices
    Kate Dupuis, Lia Tsotsos
    Multimodal Technologies and Interaction.2018; 2(3): 43.     CrossRef
  • Axial Myopia and Low HbA1c Level are Correlated and Have a Suppressive Effect on Diabetes and Diabetic Retinopathy
    Hong Kyu Kim, Tyler Hyungtaek Rim, Jong Yun Yang, Soo Han Kim, Sung Soo Kim
    Journal of Retina.2018; 3(1): 26.     CrossRef
  • The Application of Medical Artificial Intelligence Technology in Rural Areas of Developing Countries
    Jonathan Guo, Bin Li
    Health Equity.2018; 2(1): 174.     CrossRef
  • An Internet-based health gateway device for interactive communication and automatic data uploading: Clinical efficacy for type 2 diabetes in a multi-centre trial
    Jae Hyoung Cho, Hun-Sung Kim, Seung Hyun Yoo, Chang Hee Jung, Woo Je Lee, Cheol Young Park, Hae Kyung Yang, Joong Yeol Park, Sung Woo Park, Kun Ho Yoon
    Journal of Telemedicine and Telecare.2017; 23(6): 595.     CrossRef
  • Impact of initial active engagement in self-monitoring with a telemonitoring device on glycemic control among patients with type 2 diabetes
    Min-Kyung Lee, Kwang-Hyeon Lee, Seung-Hyun Yoo, Cheol-Young Park
    Scientific Reports.2017;[Epub]     CrossRef
  • An information and communication technology-based centralized clinical trial to determine the efficacy and safety of insulin dose adjustment education based on a smartphone personal health record application: a randomized controlled trial
    Gyuri Kim, Ji Cheol Bae, Byoung Kee Yi, Kyu Yeon Hur, Dong Kyung Chang, Moon-Kyu Lee, Jae Hyeon Kim, Sang-Man Jin
    BMC Medical Informatics and Decision Making.2017;[Epub]     CrossRef
  • Satisfaction Survey on Information Technology-Based Glucose Monitoring System Targeting Diabetes Mellitus in Private Local Clinics in Korea
    Hun-Sung Kim, So Jung Yang, Yoo Jin Jeong, Young-Eun Kim, Seok-Won Hong, Jae Hyoung Cho
    Diabetes & Metabolism Journal.2017; 41(3): 213.     CrossRef
  • Social Networking Services-Based Communicative Care for Patients with Diabetes Mellitus in Korea
    Hun-Sung Kim, Yoo Jeong, Sun Baik, So Yang, Tong Kim, Hyunah Kim, Hyunyong Lee, Seung-Hwan Lee, Jae Cho, In-Young Choi, Kun-Ho Yoon
    Applied Clinical Informatics.2016; 07(03): 899.     CrossRef
  • Randomized, Open-Label, Parallel Group Study to Evaluate the Effect of Internet-Based Glucose Management System on Subjects with Diabetes in China
    Hun-Sung Kim, Chenglin Sun, So Jung Yang, Lin Sun, Fei Li, In Young Choi, Jae-Hyoung Cho, Guixia Wang, Kun-Ho Yoon
    Telemedicine and e-Health.2016; 22(8): 666.     CrossRef
  • Current Clinical Status of Telehealth in Korea: Categories, Scientific Basis, and Obstacles
    Hun-Sung Kim, Hyunah Kim, Suehyun Lee, Kye Hwa Lee, Ju Han Kim
    Healthcare Informatics Research.2015; 21(4): 244.     CrossRef
Close layer
Obesity and Metabolism
Clinical Implications of Glucose Variability: Chronic Complications of Diabetes
Hye Seung Jung
Endocrinol Metab. 2015;30(2):167-174.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.167
  • 5,349 View
  • 92 Download
  • 66 Web of Science
  • 68 Crossref
AbstractAbstract PDFPubReader   

Glucose variability has been identified as a potential risk factor for diabetic complications; oxidative stress is widely regarded as the mechanism by which glycemic variability induces diabetic complications. However, there remains no generally accepted gold standard for assessing glucose variability. Representative indices for measuring intraday variability include calculation of the standard deviation along with the mean amplitude of glycemic excursions (MAGE). MAGE is used to measure major intraday excursions and is easily measured using continuous glucose monitoring systems. Despite a lack of randomized controlled trials, recent clinical data suggest that long-term glycemic variability, as determined by variability in hemoglobin A1c, may contribute to the development of microvascular complications. Intraday glycemic variability is also suggested to accelerate coronary artery disease in high-risk patients.

Citations

Citations to this article as recorded by  
  • A randomized trial on the effect of transcutaneous electrical nerve stimulator on glycemic control in patients with type 2 diabetes
    Jin-Ying Lu, Horng-Yih Ou, Chung-Ze Wu, Chwen-Yi Yang, Ju-Ying Jiang, Chieh-Hsiang Lu, Yi-Der Jiang, Tien-Jyun Chang, Yi-Cheng Chang, Meng-Lun Hsieh, Wan-Chen Wu, Hung-Yuan Li, Ye-Fong Du, Ching-Han Lin, Hao-Chang Hung, Kai-Jen Tien, Nai-Cheng Yeh, Shang-
    Scientific Reports.2023;[Epub]     CrossRef
  • Association between initial in-hospital heart rate and glycemic control in patients with acute ischemic stroke and diabetes mellitus
    Ya-Wen Kuo, Jiann-Der Lee, Chuan-Pin Lee, Yen-Chu Huang, Meng Lee
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • Practical Application of Continuous Glucose Monitoring in Clinical Practice: Case Studies
    Jeff Unger, Denise R. Franco
    Diabetes Technology & Therapeutics.2023; 25(S3): S-21.     CrossRef
  • Comparison of Glycemia Risk Index with Time in Range for Assessing Glycemic Quality
    Ji Yoon Kim, Jee Hee Yoo, Jae Hyeon Kim
    Diabetes Technology & Therapeutics.2023; 25(12): 883.     CrossRef
  • Personalized diabetes monitoring platform leveraging IoMT and AI for non-invasive estimation
    Durga Padmavilochanan, Rahul Krishnan Pathinarupothi, K.A. Unnikrishna Menon, Harish Kumar, Ramesh Guntha, Maneesha V. Ramesh, P. Venkat Rangan
    Smart Health.2023; 30: 100428.     CrossRef
  • Acute effects of drinks containing blackcurrant and citrus (poly)phenols and dietary fibre on postprandial glycaemia, gut hormones, cognitive function and appetite in healthy adults: two randomised controlled trials
    Ana M. Pinto, Mark R. Hobden, Katherine D. Brown, Jonathan Farrimond, Darren Targett, Christopher P. Corpe, Peter R. Ellis, Yvanna Todorova, Klaudia Socha, Shatha Bahsoon, Claudia Haworth, Morgane Marcel, Xirui Nie, Wendy L. Hall
    Food & Function.2023; 14(22): 10163.     CrossRef
  • Metabolomics in diabetes mellitus: clinical insight
    Shereen M. Aleidi, Hiba Al Fahmawi, Afshan Masood, Anas Abdel Rahman
    Expert Review of Proteomics.2023; 20(12): 451.     CrossRef
  • Effects of Teneligliptin on HbA1c levels, Continuous Glucose Monitoring-Derived Time in Range and Glycemic Variability in Elderly Patients with T2DM (TEDDY Study)
    Ji Cheol Bae, Soo Heon Kwak, Hyun Jin Kim, Sang-Yong Kim, You-Cheol Hwang, Sunghwan Suh, Bok Jin Hyun, Ji Eun Cha, Jong Chul Won, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2022; 46(1): 81.     CrossRef
  • Glycemic Variability and Diabetes Mellitus
    Han Na Jang, Hye Seung Jung
    The Journal of Korean Diabetes.2022; 23(1): 12.     CrossRef
  • Comparison of the Impact of Insulin Degludec U100 and Insulin Glargine U300 on Glycemic Variability and Oxidative Stress in Insulin-Naive Patients With Type 2 Diabetes Mellitus: Pilot Study for a Randomized Trial
    Pavle Vrebalov Cindro, Mladen Krnić, Darko Modun, Jonatan Vuković, Tina Tičinović Kurir, Goran Kardum, Doris Rušić, Ana Šešelja Perišin, Josipa Bukić
    JMIR Formative Research.2022; 6(7): e35655.     CrossRef
  • Endothelial Dysfunction and Platelet Hyperactivation in Diabetic Complications Induced by Glycemic Variability
    Ye Huang, Long Yue, Jiahuang Qiu, Ming Gao, Sijin Liu, Jingshang Wang
    Hormone and Metabolic Research.2022; 54(07): 419.     CrossRef
  • Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective
    Wei Yu, Iqra Ilyas, Xuerui Hu, Suowen Xu, Hui Yu
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Effect of Dapagliflozin as an Add-on Therapy to Insulin on the Glycemic Variability in Subjects with Type 2 Diabetes Mellitus (DIVE): A Multicenter, Placebo-Controlled, Double-Blind, Randomized Study
    Seung-Hwan Lee, Kyung-Wan Min, Byung-Wan Lee, In-Kyung Jeong, Soon-Jib Yoo, Hyuk-Sang Kwon, Yoon-Hee Choi, Kun-Ho Yoon
    Diabetes & Metabolism Journal.2021; 45(3): 339.     CrossRef
  • Association of time in range, as assessed by continuous glucose monitoring, with painful diabetic polyneuropathy
    Junpeng Yang, Xueli Yang, Dongni Zhao, Xiaobing Wang, Wei Wei, Huijuan Yuan
    Journal of Diabetes Investigation.2021; 12(5): 828.     CrossRef
  • The Association Between Continuous Glucose Monitoring-Derived Metrics and Cardiovascular Autonomic Neuropathy in Outpatients with Type 2 Diabetes
    Min Young Kim, Gyuri Kim, Ji Yun Park, Min Sun Choi, Ji Eun Jun, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
    Diabetes Technology & Therapeutics.2021; 23(6): 434.     CrossRef
  • Current concepts and clinical importance of glycemic variability
    Ramya Ravi, V Balasubramaniam, Gowthamarajan Kuppusamy, Sivasankaran Ponnusankar
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2021; 15(2): 627.     CrossRef
  • Glycemic deviation index: a novel method of integrating glycemic numerical value and variability
    Yizhou Zou, Wanli Wang, Dongmei Zheng, Xu Hou
    BMC Endocrine Disorders.2021;[Epub]     CrossRef
  • Relationship between short and long-term glycemic variability and oxidative stress in type 1 diabetes mellitus under daily life insulin treatment
    Tatiana Valente, Fernando Valente, Maria Beatriz Bastos Lucchesi, Giovana Rita Punaro, Margaret Gori Mouro, Monica Andrade Lima Gabbay, Elisa Mieko Suemitsu Higa, Sergio Atala Dib
    Archives of Endocrinology and Metabolism.2021;[Epub]     CrossRef
  • Evidence of Early Diabetic Nephropathy in Pediatric Type 1 Diabetes
    Leena Mamilly, Lucy D. Mastrandrea, Claudia Mosquera Vasquez, Brett Klamer, Mahmoud Kallash, Ahmad Aldughiem
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Glucose Variability and Risk of Hepatocellular Carcinoma in Patients with Diabetes: A Nationwide Population-Based Study
    Jeong-Ju Yoo, Eun Ju Cho, Kyungdo Han, Soo Seong Heo, Bo-Yeon Kim, Dong Wook Shin, Su Jong Yu
    Cancer Epidemiology, Biomarkers & Prevention.2021; 30(5): 974.     CrossRef
  • Effect of glucose concentration and culture substrate on HUVECs viability in in vitro cultures: A literature review and own results
    Anna Ciechanowska, Ilona Gora, Stanislawa Sabalinska, Piotr Foltynski, Piotr Ladyzynski
    Biocybernetics and Biomedical Engineering.2021; 41(4): 1390.     CrossRef
  • Time to Reach Target Glycosylated Hemoglobin Is Associated with Long-Term Durable Glycemic Control and Risk of Diabetic Complications in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A 6-Year Observational Study
    Kyoung Jin Kim, Jimi Choi, Jae Hyun Bae, Kyeong Jin Kim, Hye Jin Yoo, Ji A Seo, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Sin Gon Kim, Nam Hoon Kim
    Diabetes & Metabolism Journal.2021; 45(3): 368.     CrossRef
  • Immunosuppressive PLGA TGF-β1 Microparticles Induce Polyclonal and Antigen-Specific Regulatory T Cells for Local Immunomodulation of Allogeneic Islet Transplants
    Ying Li, Anthony W. Frei, Irayme M. Labrada, Yanan Rong, Jia-Pu Liang, Magdalena M. Samojlik, Chuqiao Sun, Steven Barash, Benjamin G. Keselowsky, Allison L. Bayer, Cherie L. Stabler
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Retrospective study of glycemic variability, BMI, and blood pressure in diabetes patients in the Digital Twin Precision Treatment Program
    Paramesh Shamanna, Mala Dharmalingam, Rakesh Sahay, Jahangir Mohammed, Maluk Mohamed, Terrence Poon, Nathan Kleinman, Mohamed Thajudeen
    Scientific Reports.2021;[Epub]     CrossRef
  • Dulaglutide improves muscle function by attenuating inflammation through OPA-1-TLR-9 signaling in aged mice
    Phyu Phyu Khin, Yeonhee Hong, MyeongHoon Yeon, Dae Ho Lee, Jong Han Lee, Hee-Sook Jun
    Aging.2021; 13(18): 21962.     CrossRef
  • Glycemic Variability, Oxidative Stress, and Impact on Complications Related to Type 2 Diabetes Mellitus
    Tatiana Valente, Alberto K. Arbex
    Current Diabetes Reviews.2021;[Epub]     CrossRef
  • The impact of structured self-monitoring of blood glucose on glycaemic variability in non-insulin treated type 2 diabetes: The SMBG study, a 12-month randomised controlled trial
    David M. Williams, Sharon N. Parsons, Gareth J. Dunseath, Jeffrey W. Stephens, Stephen D. Luzio, David R. Owens
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(2): 101.     CrossRef
  • Model‐based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine
    Emma C. E. Meessen, Fianne L. P. Sips, Hannah M. Eggink, Martijn Koehorst, Johannes A. Romijn, Albert K. Groen, Natal A. W. Riel, Maarten R. Soeters
    Physiological Reports.2020;[Epub]     CrossRef
  • How tightly controlled do fluctuations in blood glucose levels need to be to reduce the risk of developing complications in people with Type 1 diabetes?
    R. Livingstone, J. G. Boyle, J. R. Petrie
    Diabetic Medicine.2020; 37(4): 513.     CrossRef
  • Simple Linear Support Vector Machine Classifier Can Distinguish Impaired Glucose Tolerance Versus Type 2 Diabetes Using a Reduced Set of CGM-Based Glycemic Variability Indices
    Enrico Longato, Giada Acciaroli, Andrea Facchinetti, Alberto Maran, Giovanni Sparacino
    Journal of Diabetes Science and Technology.2020; 14(2): 297.     CrossRef
  • Vascular Complication in Adolescents With Diabetes Mellitus
    Lara E. Graves, Kim C. Donaghue
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • The Association Between Glycemic Variability and Macronutrients in Young Children with T1D
    Alexandra D Monzon, Laura B Smith, Scott W Powers, Lawrence M Dolan, Susana R Patton
    Journal of Pediatric Psychology.2020; 45(7): 749.     CrossRef
  • Effect of sancai powder on glacemic variability of type 1 diabetes in China
    Weiwei Yu, Dongqi Zhou, Li Zhang, Chen Rumeng, Peishuai Zhang, Lisha Sun, Ziping Gao
    Medicine.2020; 99(34): e20772.     CrossRef
  • Glycemic variability in newly diagnosed diabetic cats treated with the glucagon‐like peptide‐1 analogue exenatide extended release
    Anna L. Krämer, Angelina Riederer, Federico Fracassi, Felicitas S. Boretti, Nadja S. Sieber‐Ruckstuhl, Thomas A. Lutz, Barbara Contiero, Eric Zini, Claudia E. Reusch
    Journal of Veterinary Internal Medicine.2020; 34(6): 2287.     CrossRef
  • The Association Between Glycemic Variability and Myocardial Infarction: A Review and Meta-Analysis of Prospective Studies and Randomized Trials
    Zinab Alatawi, Hyder Mirghani
    Cureus.2020;[Epub]     CrossRef
  • Epigenetic regulation by polyphenols in diabetes and related complications
    Hammad Ullah, Anna De Filippis, Cristina Santarcangelo, Maria Daglia
    Mediterranean Journal of Nutrition and Metabolism.2020; 13(4): 289.     CrossRef
  • A Protective Role of Paeoniflorin in Fluctuant Hyperglycemia-Induced Vascular Endothelial Injuries through Antioxidative and Anti-Inflammatory Effects and Reduction of PKCβ1
    Jing-Shang Wang, Ye Huang, Shuping Zhang, Hui-Jun Yin, Lei Zhang, Yan-Hong Zhang, Ye-Wen Song, Dan-Dan Li
    Oxidative Medicine and Cellular Longevity.2019; 2019: 1.     CrossRef
  • The mechanisms of glycemic variability accelerate diabetic central neuropathy and diabetic peripheral neuropathy in diabetic rats
    Junpeng Yang, Zhigang Zhao, Huijuan Yuan, Xiangxiang Ma, Yakun Li, Huimeng Wang, Xiaojun Ma, Guijun Qin
    Biochemical and Biophysical Research Communications.2019; 510(1): 35.     CrossRef
  • Glucose Variability and Coronary Artery Disease
    Jinggang Xia, Chunlin Yin
    Heart, Lung and Circulation.2019; 28(4): 553.     CrossRef
  • Phase 1 Study of the Pharmacology of BTI320 Before High‐Glycemic Meals
    David R. Luke, Karen Ka Yan Lee, Carl W. Rausch, Camille Cheng
    Clinical Pharmacology in Drug Development.2019; 8(3): 395.     CrossRef
  • Information Technology for Supporting Self-Control in the Formation of a Rational Lifestyle for Diabetics Patients
    S. KIFORENKO, T. HONTAR, V. ORLENKO, K. IVASKIVA, T. OBELETS
    Kibernetika i vyčislitelʹnaâ tehnika.2019; 2019(3(197)): 80.     CrossRef
  • Impact of Carbohydrate on Glucose Variability in Patients with Type 1 Diabetes Assessed Through Professional Continuous Glucose Monitoring: A Retrospective Study
    Yi-Hsuan Lin, Yu-Yao Huang, Hsin-Yun Chen, Sheng-Hwu Hsieh, Jui-Hung Sun, Szu-Tah Chen, Chia-Hung Lin
    Diabetes Therapy.2019; 10(6): 2289.     CrossRef
  • Tracking the Sugar Rush: Incorporating Continuous Glucose Monitoring Into Multisite Early Clinical Research With Type 2 Diabetes Subjects
    Sabina Paglialunga, Bruce H. Morimoto, Amparo de la Peña, Caroline Fortier
    Clinical Pharmacology in Drug Development.2018; 7(7): 676.     CrossRef
  • Higher Total Insulin Dose Has Positive Effect on Corneal Nerve Fibers in DM1 Patients
    Gabriela Mahelková, Marie Ceská Burdová, Šárka Malá, Lucie Hoskovcová, Dagmar Dotrelová, Katerina Štechová
    Investigative Opthalmology & Visual Science.2018; 59(10): 3800.     CrossRef
  • Relationship between Thyroid Function and Kidney Function in Patients with Type 2 Diabetes
    Ying Zhang, Yang Wang, Xiao Jun Tao, Qian Li, Feng Fei Li, Kok Onn Lee, Dong Mei Li, Jian Hua Ma
    International Journal of Endocrinology.2018; 2018: 1.     CrossRef
  • The correlation between glucose fluctuation from self-monitored blood glucose and the major adverse cardiac events in diabetic patients with acute coronary syndrome during a 6-month follow-up by WeChat application
    Jinggang Xia, Shaodong Hu, Ji Xu, Hengjian Hao, Chunlin Yin, Dong Xu
    Clinical Chemistry and Laboratory Medicine (CCLM).2018; 56(12): 2119.     CrossRef
  • Glycemic Variability Percentage: A Novel Method for Assessing Glycemic Variability from Continuous Glucose Monitor Data
    Thomas A. Peyser, Andrew K. Balo, Bruce A. Buckingham, Irl B. Hirsch, Arturo Garcia
    Diabetes Technology & Therapeutics.2018; 20(1): 6.     CrossRef
  • Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo-controlled clinical trial
    Han Seok Choi, Sunmi Kim, Min Jung Kim, Myung-Sunny Kim, Juewon Kim, Chan-Woong Park, Daebang Seo, Song Seok Shin, Sang Woo Oh
    Journal of Ginseng Research.2018; 42(1): 90.     CrossRef
  • Resistance to Data Loss of Glycemic Variability Measurements in Long-Term Continuous Glucose Monitoring
    Przemysław Kucharski, Konrad Pagacz, Agnieszka Szadkowska, Wojciech Młynarski, Andrzej Romanowski, Wojciech Fendler
    Diabetes Technology & Therapeutics.2018; 20(12): 833.     CrossRef
  • Investigation of glucose fluctuations by approaches of multi-scale analysis
    Yunyun Lai, Zhengbo Zhang, Peiyao Li, Xiaoli Liu, YiXin Liu, Yi Xin, Weijun Gu
    Medical & Biological Engineering & Computing.2018; 56(3): 505.     CrossRef
  • Shared Responsibility for Type 1 Diabetes Care Is Associated With Glycemic Variability and Risk of Glycemic Excursions in Youth
    Arwen M Marker, Amy E Noser, Mark A Clements, Susana R Patton
    Journal of Pediatric Psychology.2018; 43(1): 61.     CrossRef
  • Self Blood Glucose Monitoring Underestimates Hyperglycemia And Hypoglycemia As Compared To Continuous Glucose Monitoring In Type 1 And Type 2 Diabetes
    Devna Mangrola, Christine Cox, Arianne S. Furman, Sridevi Krishnan, Sidika E. Karakas
    Endocrine Practice.2018; 24(1): 47.     CrossRef
  • Risk factors for the development of micro-vascular complications of type 2 diabetes in a single-centre cohort of patients
    Marsida Teliti, Giulia Cogni, Lucia Sacchi, Arianna Dagliati, Simone Marini, Valentina Tibollo, Pasquale De Cata, Riccardo Bellazzi, Luca Chiovato
    Diabetes and Vascular Disease Research.2018; 15(5): 424.     CrossRef
  • Glucotypes reveal new patterns of glucose dysregulation
    Heather Hall, Dalia Perelman, Alessandra Breschi, Patricia Limcaoco, Ryan Kellogg, Tracey McLaughlin, Michael Snyder, Jason Locasale
    PLOS Biology.2018; 16(7): e2005143.     CrossRef
  • Glucose Outcomes with the In-Home Use of a Hybrid Closed-Loop Insulin Delivery System in Adolescents and Adults with Type 1 Diabetes
    Satish K. Garg, Stuart A. Weinzimer, William V. Tamborlane, Bruce A. Buckingham, Bruce W. Bode, Timothy S. Bailey, Ronald L. Brazg, Jacob Ilany, Robert H. Slover, Stacey M. Anderson, Richard M. Bergenstal, Benyamin Grosman, Anirban Roy, Toni L. Cordero, J
    Diabetes Technology & Therapeutics.2017; 19(3): 155.     CrossRef
  • Vildagliptin reduces plasma stromal cell‐derived factor‐1α in patients with type 2 diabetes compared with glimepiride
    Kyeong Seon Park, SooHeon Kwak, Young Min Cho, Kyong Soo Park, Hak C Jang, Seong Yeon Kim, Hye Seung Jung
    Journal of Diabetes Investigation.2017; 8(2): 218.     CrossRef
  • Role of the PKCβII/JNK signaling pathway in acute glucose fluctuation-induced apoptosis of rat vascular endothelial cells
    Na Wu, Haitao Shen, Yanjun Wang, Bing He, Yongyan Zhang, Yu Bai, Runyu Du, Qiang Du, Ping Han
    Acta Diabetologica.2017; 54(8): 727.     CrossRef
  • Association between glycemic variability and major adverse cardiovascular and cerebrovascular events (MACCE) in patients with acute coronary syndrome during 30-day follow-up
    Jinggang Xia, Ji Xu, Boyu Li, Zhi Liu, Hengjian Hao, Chunlin Yin, Dong Xu
    Clinica Chimica Acta.2017; 466: 162.     CrossRef
  • How Can We Realize the Clinical Benefits of Continuous Glucose Monitoring?
    Ramzi A. Ajjan
    Diabetes Technology & Therapeutics.2017; 19(S2): S-27.     CrossRef
  • The efficacy and safety of adding either vildagliptin or glimepiride to ongoing metformin therapy in patients with type 2 diabetes mellitus
    Gyuri Kim, Sewon Oh, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim, Moon-Kyu Lee
    Expert Opinion on Pharmacotherapy.2017; 18(12): 1179.     CrossRef
  • Association Between Coronary Artery Calcification and the Hemoglobin Glycation Index: The Kangbuk Samsung Health Study
    Eun-Jung Rhee, Jung-Hwan Cho, Hyemi Kwon, Se Eun Park, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
    The Journal of Clinical Endocrinology & Metabolism.2017; 102(12): 4634.     CrossRef
  • Glucose variability for cardiovascular risk factors in type 2 diabetes: a meta-analysis
    Shuang Liang, Hang Yin, Chunxiang Wei, Linjun Xie, Hua He, Xiaoquan Liu
    Journal of Diabetes & Metabolic Disorders.2017;[Epub]     CrossRef
  • Could angiotensin-(1–7) be connected with improvement of microvascular function in diabetic patients? Angiotensin-(1–7) iontophoresis may provide the answer
    Aleksandar Kibel
    Medical Hypotheses.2016; 93: 16.     CrossRef
  • Efficacy and Safety of PDM011011 Capsules as Compared to Metformin in Subjects with Type-2 Diabetes Mellitus: An Open-Label, Randomized, Active-Controlled, Multicentric, Phase III Study
    Ashish C. Suthar, Vikas G. Pai, Yogesh Kadam, Aniruddha Tongaonkar, Shailaja Kale, Atul B. Deshpande, Sharat Kolke, Snehal Tanna, Shrikant V. Deshpande, Purvi Chawla, Debjit Biswas, Somesh Sharma
    Journal of Diabetes Mellitus.2016; 06(01): 38.     CrossRef
  • 1,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin Therapy
    Min Kyeong Kim, Hye Seung Jung, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Seong Yeon Kim
    Endocrinology and Metabolism.2016; 31(2): 284.     CrossRef
  • The impact of glycemic variability on diabetic peripheral neuropathy
    Heung Yong Jin, Kyung Ae Lee, Tae Sun Park
    Endocrine.2016; 53(3): 643.     CrossRef
  • Serum bilirubin levels are positively associated with glycemic variability in women with type 2 diabetes
    Lee Kyung Kim, Eun Roh, Min Joo Kim, Min Kyeong Kim, Kyeong Seon Park, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Hak Chul Jang, Hye Seung Jung
    Journal of Diabetes Investigation.2016; 7(6): 874.     CrossRef
  • Wider Perioperative Glycemic Fluctuations Increase Risk of Postoperative Acute Kidney Injury
    Ming Ann Sim, Weiling Liu, Roderica R.G. Ng, Lian Kah Ti, Sophia T.H. Chew
    Medicine.2015; 94(44): e1953.     CrossRef
Close layer
Editorial
Obesity and Metabolism
Adipokine Profiles and Metabolic Health
Seung-Hwan Lee
Endocrinol Metab. 2015;30(2):175-176.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.175
  • 3,048 View
  • 30 Download
  • 5 Web of Science
  • 8 Crossref
PDFPubReader   

Citations

Citations to this article as recorded by  
  • Comparison of visceral adipose tissue in patients with autonomous cortisol secretion and patients with the nonfunctional adrenal masses
    Ferhat Can PİŞKİN, Fulya ODABAŞ, Ulcaz Perihan AKSOYDAN, Gamze AKKUŞ
    Cukurova Medical Journal.2023; 48(3): 911.     CrossRef
  • Association of adipokine levels and insulin resistance in prediabetes: hospital-based descriptive study in a tertiary care hospital in North Kerala
    C. P. Bineesh, M. V. Vimal, Vipin Viswanath, Pranav Kumar Prabhakar
    International Journal of Diabetes in Developing Countries.2023;[Epub]     CrossRef
  • Influence of BMI on Serum Adiponectin, Resistine, and FBG among Overweight and Obese Females Diabetic Patient Type2
    Salah Eldin Omar Hussein, Abd Elgadir Alamin Altoum, Ahmed L. Osman, Hassan M. K. I. Higazi, Sara Ali, Ayman Hussien Alfeel
    Open Access Macedonian Journal of Medical Sciences.2022; 10(B): 1218.     CrossRef
  • Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes
    Teresa Salvatore, Raffaele Galiero, Alfredo Caturano, Luca Rinaldi, Livio Criscuolo, Anna Di Martino, Gaetana Albanese, Erica Vetrano, Christian Catalini, Celestino Sardu, Giovanni Docimo, Raffaele Marfella, Ferdinando Carlo Sasso
    International Journal of Molecular Sciences.2022; 24(1): 658.     CrossRef
  • THE ROLE OF RESISTIN IN THE PROGRESSION OF NON-ALCOHOLIC FATTY LIVER DISEASE
    L.V. Zhuravlyova, O.V. Elhaj
    Inter Collegas.2021; 8(3): 157.     CrossRef
  • Serum leptin, resistin, and adiponectin levels in obese and non-obese patients with newly diagnosed type 2 diabetes mellitus
    Wei Liu, Xianghai Zhou, Yufeng Li, Simin Zhang, Xiaoling Cai, Rui Zhang, Siqian Gong, Xueyao Han, Linong Ji
    Medicine.2020; 99(6): e19052.     CrossRef
  • Adipose Tissue-Derived Signatures for Obesity and Type 2 Diabetes: Adipokines, Batokines and MicroRNAs
    Min-Woo Lee, Mihye Lee, Kyoung-Jin Oh
    Journal of Clinical Medicine.2019; 8(6): 854.     CrossRef
  • Effect of a new PPAR-gamma agonist, lobeglitazone, on neointimal formation after balloon injury in rats and the development of atherosclerosis
    Soo Lim, Kuy-Sook Lee, Jie Eun Lee, Ho Seon Park, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Kyong Soo Park, Young Bum Kim, Hak Chul Jang
    Atherosclerosis.2015; 243(1): 107.     CrossRef
Close layer
Original Articles
Obesity and Metabolism
Exendin-4 Inhibits the Expression of SEPP1 and Fetuin-A via Improvement of Palmitic Acid-Induced Endoplasmic Reticulum Stress by AMPK
Jinmi Lee, Seok-Woo Hong, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
Endocrinol Metab. 2015;30(2):177-184.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.177
  • 4,168 View
  • 40 Download
  • 12 Web of Science
  • 10 Crossref
AbstractAbstract PDFPubReader   
Background

Selenoprotein P (SEPP1) and fetuin-A, both circulating liver-derived glycoproteins, are novel biomarkers for insulin resistance and nonalcoholic fatty liver disease. However, the effect of exendin-4 (Ex-4), a glucagon-like peptide-1 receptor agonist, on the expression of hepatokines, SEPP1, and fetuin-A, is unknown.

Methods

The human hepatoma cell line HepG2 was treated with palmitic acid (PA; 0.4 mM) and tunicamycin (tuni; 2ug/ml) with or without exendin-4 (100 nM) for 24 hours. The change in expression of PA-induced SEPP1, fetuin-A, and endoplasmic reticulum (ER) stress markers by exendin-4 treatment were evaluated using quantitative real-time reverse transcription polymerase chain reaction and Western blotting. Transfection of cells with AMP-activated protein kinase (AMPK) small interfering RNA (siRNA) was performed to establish the effect of exendin-4-mediated AMPK in the regulation of SEPP1 and fetuin-A expression.

Results

Exendin-4 reduced the expression of SEPP1, fetuin-A, and ER stress markers including PKR-like ER kinase, inositol-requiring kinase 1α, activating transcription factor 6, and C/EBP homologous protein in HepG2 cells. Exendin-4 also reduced the expression of SEPP1 and fetuin-A in cells treated with tunicamycin, an ER stress inducer. In cells treated with the AMPK activator 5-aminoidazole-4-carboxamide ribonucleotide (AICAR), the expression of hepatic SEPP1 and fetuin-A were negatively related by AMPK, which is the target of exendin-4. In addition, exendin-4 treatment did not decrease SEPP1 and fetuin-A expression in cells transfected with AMPK siRNA.

Conclusion

These data suggest that exendin-4 can attenuate the expression of hepatic SEPP1 and fetuin-A via improvement of PA-induced ER stress by AMPK.

Citations

Citations to this article as recorded by  
  • Maternal Organic Selenium Supplementation Relieves Intestinal Endoplasmic Reticulum Stress in Piglets by Enhancing the Expression of Glutathione Peroxidase 4 and Selenoprotein S
    Dajiang Ding, Daolin Mou, Heng Zhu, Xuemei Jiang, Lianqiang Che, Zhengfeng Fang, Shengyu Xu, Yan Lin, Yong Zhuo, Jian Li, Chao Huang, Yuanfeng Zou, Lixia Li, De Wu, Bin Feng
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Alliin, capsaicin, and gingerol attenuate endoplasmic reticulum stress-induced hepatic steatosis in HepG2 cells and C57BL/6N mice
    Ye-Rang Yun, Ji-Eun Lee
    Journal of Functional Foods.2022; 95: 105186.     CrossRef
  • PNPLA3 I148M is involved in the variability in anti-NAFLD response to exenatide
    Yunzhi Chen, Xuemei Yan, Xiao Xu, Shuhua Yuan, Fen Xu, Hua Liang
    Endocrine.2020; 70(3): 517.     CrossRef
  • Green tea extracts reduce leukocyte cell–Derived chemotaxin 2 and selenoprotein P levels in the livers of C57BL/6J mice fed a high-fat diet
    Shintaro Onishi, Hidefumi Kitazawa, Shinichi Meguro, Ichiro Tokimitsu
    Bioscience, Biotechnology, and Biochemistry.2018; 82(9): 1568.     CrossRef
  • Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha‐2‐HS‐glycoprotein
    Jee‐In Heo, Dae Wui Yoon, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Nan Hee Kim
    Journal of Pineal Research.2018;[Epub]     CrossRef
  • Palmitic acid induces ceramide accumulation, mitochondrial protein hyperacetylation, and mitochondrial dysfunction in porcine oocytes†
    Nobuhiko Itami, Koumei Shirasuna, Takehito Kuwayama, Hisataka Iwata
    Biology of Reproduction.2018; 98(5): 644.     CrossRef
  • Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation
    Bing Zhou, Dan-li Zhou, Xiao-hong Wei, Rong-yu Zhong, Jie Xu, Liao Sun
    Acta Pharmacologica Sinica.2017; 38(7): 998.     CrossRef
  • New Potential Targets of Glucagon-Like Peptide 1 Receptor Agonists in Pancreatic β-Cells and Hepatocytes
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 1.     CrossRef
  • Selenoprotein P neutralizes lipopolysaccharide and participates in hepatic cell endoplasmic reticulum stress response
    Yongzhong Zhao, Shuvojit Banerjee, Ping Huang, Xinning Wang, Candece L. Gladson, Warren D. Heston, Charles B. Foster
    FEBS Letters.2016; 590(24): 4519.     CrossRef
  • Novel phenotypes of prediabetes?
    Hans-Ulrich Häring
    Diabetologia.2016; 59(9): 1806.     CrossRef
Close layer
Obesity and Metabolism
Comparison of Serum Adipocytokine Levels according to Metabolic Health and Obesity Status
Tae Hoon Lee, Won Seon Jeon, Ki Joong Han, Shin Yeoung Lee, Nam Hee Kim, Hyun Beom Chae, Choel Min Jang, Kyung Mo Yoo, Hae Jung Park, Min Kyung Lee, Se Eun Park, Hyung Geun Oh, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
Endocrinol Metab. 2015;30(2):185-194.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.185
  • 4,361 View
  • 33 Download
  • 15 Web of Science
  • 15 Crossref
AbstractAbstract PDFPubReader   
Background

Metabolic health is an emerging concept that is highly correlated with various metabolic complications, and adipocytokines have been causally linked to a wide range of metabolic diseases. Thus, this study compared serum adipocytokine levels according to metabolic health and obesity status.

Methods

Four hundred and fifty-six nondiabetic subjects (mean age, 40.5 years) were categorized into four groups according to metabolic health and obesity status: metabolically healthy nonobese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy nonobese (MUHNO), and metabolically unhealthy obese (MUHO). Being metabolically healthy was defined as the presence of fewer than two of the following five metabolic abnormalities: high blood pressure, high fasting blood glucose, high triglyceride, low high density lipoprotein cholesterol, and being in the highest decile of the homeostatic model assessment of insulin resistance index. Obesity status was assessed using body mass index (BMI), with obesity defined as a BMI higher than 25 kg/m2. Levels of serum interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor α (TNF-α), and adipocyte fatty acid binding protein (A-FABP) were also evaluated.

Results

Of the 456 subjects, 247 (54.2%) were in the MHNO group, 66 (14.5%) were in the MHO group, 66 (14.5%) were in the MUHNO group, and 77 (16.9%) were in the MUHO group. There were no significant differences in IL-6 or MCP-1 levels among the groups, but levels of TNF-α and A-FABP were significantly higher in the MUHNO group compared to the MHNO group.

Conclusion

High TNF-α and A-FABP levels are significantly associated with metabolically unhealthiness in nonobese Korean individuals.

Citations

Citations to this article as recorded by  
  • Relationship between the thrombospondin-1/Toll-like receptor 4 (TSP1/TLR4) pathway and vitamin D levels in obese and normal weight subjects with different metabolic phenotypes
    Eman Y. Khairy, Azza Saad
    The Journal of Physiological Sciences.2023;[Epub]     CrossRef
  • Differences in the levels of inflammatory markers between metabolically healthy obese and other obesity phenotypes in adults: A systematic review and meta-analysis
    Zhouli Su, Ljupcho Efremov, Rafael Mikolajczyk
    Nutrition, Metabolism and Cardiovascular Diseases.2023;[Epub]     CrossRef
  • Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?
    Lourdes Balcázar-Hernandez, Lourdes Basurto, Leticia Manuel-Apolinar, Sara Vega-García, Norma Basurto-Acevedo, Carlos Martínez-Murillo, Rosalinda Sánchez-Arenas
    Metabolites.2021; 11(11): 771.     CrossRef
  • Exploring Therapeutic Targets to Reverse or Prevent the Transition from Metabolically Healthy to Unhealthy Obesity
    Tenzin D. Dagpo, Christopher J. Nolan, Viviane Delghingaro-Augusto
    Cells.2020; 9(7): 1596.     CrossRef
  • Poor Vitamin D Status in Active Pulmonary Tuberculosis Patients and Its Correlation with Leptin and TNF-α
    Qiuzhen WANG, Aiguo MA, Tianlin GAO, Yufeng LIU, Lisheng REN, Lei HAN, Boyang WEI, Qian LIU, Chunjiang DONG, Yuze MU, Duo LI, Frans J KOK, Evert G SCHOUTEN
    Journal of Nutritional Science and Vitaminology.2019; 65(5): 390.     CrossRef
  • Metabolic Health—The Role of Adipo-Myokines
    Christine Graf, Nina Ferrari
    International Journal of Molecular Sciences.2019; 20(24): 6159.     CrossRef
  • Does the Metabolically Healthy Obese Phenotype Protect Adults with Class III Obesity from Biochemical Alterations Related to Bone Metabolism?
    Ligiane Marques Loureiro, Suzane Lessa, Rodrigo Mendes, Sílvia Pereira, Carlos José Saboya, Andrea Ramalho
    Nutrients.2019; 11(9): 2125.     CrossRef
  • Being Metabolically Healthy, the Most Responsible Factor for Vascular Health
    Eun-Jung Rhee
    Diabetes & Metabolism Journal.2018; 42(1): 19.     CrossRef
  • Association between Serum Dipeptidyl Peptidase-4 Concentration and Obesity-related Factors in Health Screen Examinees
    Ji Yeon Lee, Byoung Kuk Jang, Min Kyung Song, Hye Soon Kim, Mi-Kyung Kim
    Journal of Obesity & Metabolic Syndrome.2017; 26(3): 188.     CrossRef
  • Kofaktoren und Komorbiditäten bei Necrobiosis lipoidica – Analyse der deutschen DRG‐Daten von 2012
    Finja Jockenhöfer, Knut Kröger, Joachim Klode, Regina Renner, Cornelia Erfurt‐Berge, Joachim Dissemond
    JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2016; 14(3): 277.     CrossRef
  • The relationship between serum fatty-acid binding protein 4 level and lung function in Korean subjects with normal ventilatory function
    Hye-Jeong Park, Se Eun Park, Cheol-Young Park, Seong Yong Lim, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
    BMC Pulmonary Medicine.2016;[Epub]     CrossRef
  • Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012
    Finja Jockenhöfer, Knut Kröger, Joachim Klode, Regina Renner, Cornelia Erfurt‐Berge, Joachim Dissemond
    JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2016; 14(3): 277.     CrossRef
  • Response: Comparison of Serum Adipocytokine Levels according to Metabolic Health and Obesity Status (Endocrinol Metab2015;30:185-94, Tae Hoon Lee et al.)
    Eun-Jung Rhee
    Endocrinology and Metabolism.2015; 30(3): 416.     CrossRef
  • Letter: Comparison of Serum Adipocytokine Levels according to Metabolic Health and Obesity Status (Endocrinol Metab2015;30:185-94, Tae Hoon Lee et al.)
    Mikyung Kim
    Endocrinology and Metabolism.2015; 30(3): 414.     CrossRef
  • Adipokine Profiles and Metabolic Health
    Seung-Hwan Lee
    Endocrinology and Metabolism.2015; 30(2): 175.     CrossRef
Close layer
Thyroid
Anaplastic Thyroid Cancer: Experience of the Philippine General Hospital
Tom Edward Lo, Cecilia Alegado Jimeno, Elizabeth Paz-Pacheco
Endocrinol Metab. 2015;30(2):195-200.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.195
  • 3,257 View
  • 40 Download
  • 4 Web of Science
  • 4 Crossref
AbstractAbstract PDFPubReader   
Background

Anaplastic thyroid cancer (ATC) is a rare type of thyroid malignancy and one of the most aggressive solid tumors, responsible for between 14% and 50% of the total annual mortality associated with thyroid cancer.

Methods

A retrospective study was made of all ATC cases diagnosed by biopsy in the Philippine General Hospital between 2008 and 2013.

Results

A total of 15 patients were identified, with a median age at diagnosis of 63 years. All tumors were at least 6 cm in size upon diagnosis. All patients had a previous history of thyroid pathology, presenting with an average duration of 11 years. Eleven patients presented with cervical lymphadenopathies, whereas seven exhibited signs of distant metastases, for which the lungs appeared to be the most common site. More than 70% of the patients presented with a rapidly growing neck mass, leading to airway obstruction. Only three patients were treated using curative surgery; the majority received palliative and supportive forms of treatment. In addition, only three patients were offered radiotherapy. Chemotherapy was not offered to any patient. Only two patients were confirmed to still be alive during the study period. The median survival time for the other patients was 3 months; in the majority of cases the patient died within the first year following diagnosis.

Conclusion

Our experience with ATC demonstrated concordance with other institutions with respect to current clinical profile, presentation, and prognosis. An absence of distant metastases and lymph node involvement was associated with improved survival outcomes, whereas age at diagnosis and tumor size did not affect survival. Curative surgery offers the most effective means of prolonging survival. Radiotherapy and chemotherapy in combination with surgery represents a promising treatment strategy.

Citations

Citations to this article as recorded by  
  • Prior Thyroid and Nonthyroid Cancer History Do Not Significantly Alter Overall Survival in Patients Diagnosed with Anaplastic Thyroid Cancer
    Yu Han Chen, Maria Cabanillas, Jared Sperling, Li Xu, Maitrayee Goswami, Anastasios Maniakas, Michelle D. Williams, Stephen Y. Lai, Naifa Busaidy, Ramona Dadu, Mark E. Zafereo, Jennifer Rui Wang
    Thyroid.2023; 33(3): 321.     CrossRef
  • Clinical Outcome and Toxicity in the Treatment of Anaplastic Thyroid Cancer in Elderly Patients
    Teresa Augustin, Dmytro Oliinyk, Viktoria Florentine Koehler, Josefine Rauch, Claus Belka, Christine Spitzweg, Lukas Käsmann
    Journal of Clinical Medicine.2020; 9(10): 3231.     CrossRef
  • Poorly Differentiated Thyroid Carcinoma: 10-Year Experience in a Southeast Asian Population
    Marc Gregory Yu, Jonathan Rivera, Cecilia Jimeno
    Endocrinology and Metabolism.2017; 32(2): 288.     CrossRef
  • Macrophage Densities Correlated with CXC Chemokine Receptor 4 Expression and Related with Poor Survival in Anaplastic Thyroid Cancer
    Dae In Kim, Eunyoung Kim, Young A Kim, Sun Wook Cho, Jung Ah Lim, Young Joo Park
    Endocrinology and Metabolism.2016; 31(3): 469.     CrossRef
Close layer
Obesity and Metabolism
Associations between Dietary Acid-Base Load and Cardiometabolic Risk Factors in Adults: The Tehran Lipid and Glucose Study
Zahra Bahadoran, Parvin Mirmiran, Hadise Khosravi, Fereidoun Azizi
Endocrinol Metab. 2015;30(2):201-207.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.201
  • 3,323 View
  • 28 Download
  • 31 Web of Science
  • 34 Crossref
AbstractAbstract PDFPubReader   
Background

In this study we investigated the associations of dietary acid-base load, identified by potential renal acid load (PRAL) and protein to potassium (Pro:K) ratio, with cardiometabolic risk factors in Tehranian adults.

Methods

A cross-sectional study was conducted within the framework of the fourth phase of the Tehran Lipid and Glucose Study (2009 to 2011) on 5,620 men and women aged 19 to 70 years. Dietary data were collected by a trained dietitian using a validated, 147-food item, semi-quantitative food frequency questionnaire, and dietary PRAL and Pro:K ratio were calculated. Multiple linear regression models with adjustment for potential confounding variables were used to evaluate the associations of dietary acid-base load with anthropometric measures, blood pressure, serum triglycerides, high density lipoprotein cholesterol (HDL-C), serum creatinine, and fasting blood glucose.

Results

The mean±SD age of the participants was 39.8±12.8 years and 54% of participants were women. Mean±SD PRAL was -22.0±29.1; mean PRAL was -15.6 in men and -26.8 in women. Dietary PRAL was associated with weight (β=0.098, P<0.001), waist circumference (β=0.062, P<0.01), serum triglycerides (β=0.143, P<0.01), HDL-C (β=-0.11, P<0.01), diastolic blood pressure (β=0.062, P<0.01), and serum creatinine (β=0.142, P<0.001). Pro:K ratio was associated with weight (β=0.055, P<0.001), waist circumference (β=0.04, P<0.01), serum HDL-C (β=-0.06, P<0.01), serum triglycerides (β=0.03, P<0.05), diastolic blood pressure (β=0.026, P<0.05), and serum creatinine (β=0.07, P<0.01).

Conclusion

A more acidic dietary acid-base load may be a risk factor for the development of metabolic disorders.

Citations

Citations to this article as recorded by  
  • A high dietary acid load can potentially exacerbate cardiometabolic risk factors: An updated systematic review and meta-analysis of observational studies
    Shamim Dolati, Soha Razmjouei, Mohammad Alizadeh, Amir Hossein Faghfouri, Amir Hossein Moridpour
    Nutrition, Metabolism and Cardiovascular Diseases.2024;[Epub]     CrossRef
  • Dietary acid load and cardiovascular diseases
    Nursel Sahın, Ugur Gunsen
    Critical Reviews in Food Science and Nutrition.2023; 63(28): 9033.     CrossRef
  • Health Inequities in the USA: a Role for Dietary Acid Load? Results from the National Health and Nutrition Examination Surveys
    Maximilian Andreas Storz
    Journal of Racial and Ethnic Health Disparities.2023; 10(6): 2851.     CrossRef
  • Dietary acid load is associated with waist circumference in university students with low adherence to the Mediterranean diet: The potential role of ultra-processed foods
    Paraskevi Detopoulou, Vassilios Dedes, Ioanna Pylarinou, Dimitra Syka, Konstantinos Tzirogiannis, Georgios I. Panoutsopoulos
    Clinical Nutrition ESPEN.2023; 56: 43.     CrossRef
  • Dietary acid load and its interaction with CETP TaqB1 polymorphisms on lipid profile among patients with Type 2 diabetes mellitus
    Faezeh Abaj, Zahra Esmaeily, Zeinab Naeini, Ehsan Alvandi, Masoumeh Rafiee, Fariba Koohdani
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • A Nutrigenetic Approach to Investigate ApoB EcoR1 Polymorphism-Dietary Acid Load Interactions on Lipid and Anthropometric-Related Outcomes in Adults with Dyslipidemic Type 2 Diabetes
    Zeinab Naeini, Faezeh Abaj, Zahra Esmaeily, Ehsan Alvandi, Masoumeh Rafiee, Fariba Koohdani
    Lifestyle Genomics.2023; 16(1): 61.     CrossRef
  • Interaction of dietary acid load and general and central obesity with muscle strength and skeletal muscle mass
    Saba Mohammadpour, Parivash Ghorbaninejad, Mahshid Shahavandi, Sakineh Shab-Bidar
    Clinical Nutrition ESPEN.2022; 48: 361.     CrossRef
  • Dietary acid load modifies the effects of ApoA2–265 T > C polymorphism on lipid profile and serum leptin and ghrelin levels among type 2 diabetic patients
    Faezeh Abaj, Zahra Esmaeily, Zeinab Naeini, Masoumeh Rafiee, Fariba Koohdani
    BMC Endocrine Disorders.2022;[Epub]     CrossRef
  • The association between dietary acid load and adiposity measures among children and adolescents
    Nasim Sorraya, Arman Arab, Shokoofeh Talebi
    BMC Pediatrics.2022;[Epub]     CrossRef
  • Metabolic status is not related to dietary acid load in polycystic ovary syndrome
    Tülay OMMA, Fatmanur Hümeyra ZENGİN, Süheyla AYDOĞMUŞ, Cavit ÇULHA
    Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi.2022; 55(2): 111.     CrossRef
  • EVALUATION OF THE RELATIONSHİP BETWEEN QUALITY OF LIFE AND DIETARY ACID LOAD IN OBESE WOMEN
    Nurefşan KONYALIGİL, Betül ÇİÇEK, Tuba TEKİN, Meltem ÜNLÜSAVURAN SÖNMEZ
    Karya Journal of Health Science.2022; 3(2): 145.     CrossRef
  • Carbohydrate Intake and Its Association With Dietary Acid Load in U.S. Adults: Results From a Cross-Sectional Study
    Maximilian A. Storz, Alvaro L. Ronco
    American Journal of Lifestyle Medicine.2022; : 155982762211332.     CrossRef
  • The association between dietary acid load and body composition in physical education students aged 18–25 years
    Maryam Mansordehghan, Elnaz Daneshzad, Vahid Basirat, Bahram Pourghassem Gargari, Tohid Rouzitalab
    Journal of Health, Population and Nutrition.2022;[Epub]     CrossRef
  • Association of dietary acid load with anthropometric indices in children and adolescents
    Zahra Aslani, Maryam Bahreynian, Nazli Namazi, Nitin Shivappa, James R. Hébert, Hamid Asayesh, Mohammad Esmaeil Motlagh, Mohammad Ali Pourmirzaei, Amir Kasaeian, Armita Mahdavi-Gorabi, Mostafa Qorbani, Roya Kelishadi
    Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2021; 26(2): 555.     CrossRef
  • Dietary acid load, kidney function and risk of chronic kidney disease: A systematic review and meta-analysis of observational studies
    Manije Darooghegi Mofrad, Elnaz Daneshzad, Leila Azadbakht
    International Journal for Vitamin and Nutrition Research.2021; 91(3-4): 343.     CrossRef
  • The association between dietary acid load with cardiometabolic risk factors and inflammatory markers amongst elderly men: A cross‐sectional study
    Alireza Jafari, Mahtab Ghanbari, Hossein Shahinfar, Nick Bellissimo, Leila Azadbakht
    International Journal of Clinical Practice.2021;[Epub]     CrossRef
  • Dietary Acid Load and Its Interaction with IGF1 (rs35767 and rs7136446) and IL6 (rs1800796) Polymorphisms on Metabolic Traits among Postmenopausal Women
    Sook Yee Lim, Yoke Mun Chan, Vasudevan Ramachandran, Zalilah Mohd Shariff, Yit Siew Chin, Manohar Arumugam
    Nutrients.2021; 13(7): 2161.     CrossRef
  • Associations between dietary acid load and obesity among Iranian women
    Somaye Fatahi, Mostafa Qorbani, Pamela J. Surkan, Leila Azadbakht
    Journal of Cardiovascular and Thoracic Research.2021; 13(4): 285.     CrossRef
  • Higher dietary acid load is not associated with risk of breast cancer in Iranian women
    Maryam Safabakhsh, Hossein Imani, Mehdi Yaseri, Ramesh Omranipour, Sakineh Shab‐Bidar
    Cancer Reports.2020;[Epub]     CrossRef
  • Dietary acid load, blood pressure, fasting blood sugar and biomarkers of insulin resistance among adults: Findings from an updated systematic review and meta‐analysis
    Parvin Dehghan, Mahdieh Abbasalizad Farhangi
    International Journal of Clinical Practice.2020;[Epub]     CrossRef
  • Ameliorating Chronic Kidney Disease Using a Whole Food Plant-Based Diet
    Kathleen E. Adair, Rodney G. Bowden
    Nutrients.2020; 12(4): 1007.     CrossRef
  • Positive association between dietary acid load and future insulin resistance risk: findings from the Korean Genome and Epidemiology Study
    Kyung Won Lee, Dayeon Shin
    Nutrition Journal.2020;[Epub]     CrossRef
  • Dietary Acid Load and Cardiometabolic Risk Factors—A Narrative Review
    Joanna Ostrowska, Justyna Janiszewska, Dorota Szostak-Węgierek
    Nutrients.2020; 12(11): 3419.     CrossRef
  • Dietary acid load and cardiometabolic risk factors: a systematic review and meta-analysis of observational studies
    Elnaz Daneshzad, Fahimeh Haghighatdoost, Leila Azadbakht
    Public Health Nutrition.2019; 22(15): 2823.     CrossRef
  • The Associations of Dietary Acid Load with Insulin Resistance and Type 2 Diabetes: A Systematic Review of Existing Human Studies
    Hadi Emamat, Hadith Tangestani, Zahra Bahadoran, Sajjad Khalili-Moghadam, Parvin Mirmiran
    Recent Patents on Food, Nutrition & Agriculture.2019; 10(1): 27.     CrossRef
  • Association of dietary acid load with cardiovascular risk factors and the prevalence of metabolic syndrome in Iranian women: A cross-sectional study
    Hadis Mozaffari, Nazli Namazi, Bagher Larijani, Nick Bellissimo, Leila Azadbakht
    Nutrition.2019; 67-68: 110570.     CrossRef
  • Higher dietary acid load potentially increases serum triglyceride and obesity prevalence in adults: An updated systematic review and meta-analysis
    Mahdieh Abbasalizad Farhangi, Leila Nikniaz, Zeinab Nikniaz, Raffaele Serra
    PLOS ONE.2019; 14(5): e0216547.     CrossRef
  • Dietary acid load significantly predicts 10-years survival in patients underwent coronary artery bypass grafting (CABG) surgery
    Mahdieh Abbasalizad Farhangi, Mahdi Vajdi, Mahdi Najafi, Raffaele Serra
    PLOS ONE.2019; 14(10): e0223830.     CrossRef
  • Higher dietary acid load is associated with higher likelihood of peripheral arterial disease among American adults
    Mohsen Mazidi, Dimitri P. Mikhailidis, Maciej Banach
    Journal of Diabetes and its Complications.2018; 32(6): 565.     CrossRef
  • Nutrition and Cardio-Metabolic Risk Factors: 20 Years of the Tehran Lipid and Glucose Study Findings
    Firoozeh Hosseini-Esfahani, Somaye Hosseinipour, Golaleh Asghari, Zahra Bahadoran, Nazanin Moslehi, Mahdieh Golzarand, Hanieh Ejtahed, Parvin Mirmiran, Fereidoun Azizi
    International Journal of Endocrinology and Metabolism.2018;[Epub]     CrossRef
  • Higher dietary acid load is weakly associated with higher adiposity measures and blood pressure in Japanese adults: The National Health and Nutrition Survey
    Kentaro Murakami, M. Barbara E. Livingstone, Hitomi Okubo, Satoshi Sasaki
    Nutrition Research.2017; 44: 67.     CrossRef
  • Accuracy and precision of estimation equations to predict net endogenous acid excretion using the Australian food database
    Benjamin H. Parmenter, Gary J. Slater, Lynda A. Frassetto
    Nutrition & Dietetics.2017; 74(3): 308.     CrossRef
  • Dietary acid load and mortality among Japanese men and women: the Japan Public Health Center–based Prospective Study
    Shamima Akter, Akiko Nanri, Tetsuya Mizoue, Mitsuhiko Noda, Norie Sawada, Shizuka Sasazuki, Shoichiro Tsugane
    The American Journal of Clinical Nutrition.2017; 106(1): 146.     CrossRef
  • Association between Dietary Acid Load and Insulin Resistance: Tehran Lipid and Glucose Study
    Sajjad Khalili Moghadam, Zahra Bahadoran, Parvin Mirmiran, Maryam Tohidi, Fereidoun Azizi
    Preventive Nutrition and Food Science.2016; 21(2): 104.     CrossRef
Close layer
Obesity and Metabolism
Apolipoprotein B Is Related to Metabolic Syndrome Independently of Low Density Lipoprotein Cholesterol in Patients with Type 2 Diabetes
Younghyup Lim, Soyeon Yoo, Sang Ah Lee, Sang Ouk Chin, Dahee Heo, Jae Cheol Moon, Shinhang Moon, Kiyoung Boo, Seong Taeg Kim, Hye Mi Seo, Hyeyoung Jwa, Gwanpyo Koh
Endocrinol Metab. 2015;30(2):208-215.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.208
  • 4,198 View
  • 42 Download
  • 18 Web of Science
  • 20 Crossref
AbstractAbstract PDFPubReader   
Background

Increased low density lipoprotein cholesterol (LDL-C) level and the presence of metabolic syndrome (MetS) are important risk factors for cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM). Recent studies demonstrated apolipoprotein B (apoB), a protein mainly located in LDL-C, was an independent predictor of the development of CVD especially in patients with T2DM. The aim of this study was to investigate the relationship between apoB and MetS in T2DM patients.

Methods

We analyzed 912 patients with T2DM. Fasting blood samples were taken for glycated hemoglobin, high-sensitivity C-reactive protein, total cholesterol, triglyceride (TG), high density lipoprotein cholesterol, LDL-C, and apoB. MetS was defined by the modified National Cholesterol Education Program Adult Treatment Panel III criteria. We performed a hierarchical regression analysis with apoB as the dependent variable. Age, sex, the number of components of MetS and LDL-C were entered at model 1, the use of lipid-lowering medications at model 2, and the individual components of MetS were added at model 3.

Results

Seventy percent of total subjects had MetS. ApoB level was higher in subjects with than those without MetS (104.5±53.3 mg/dL vs. 87.7±33.7 mg/dL, P<0.01) even after adjusting for LDL-C. ApoB and LDL-C were positively correlated to the number of MetS components. The hierarchical regression analysis showed that the increasing number of MetS components was associated with higher level of apoB at step 1 and step 2 (β=0.120, P<0.001 and β=0.110, P<0.001, respectively). At step 3, TG (β=0.116, P<0.001) and systolic blood pressure (β=0.099, P<0.05) were found to significantly contribute to apoB.

Conclusion

In patients with T2DM, apoB is significantly related to MetS independently of LDL-C level. Of the components of MetS, TG, and systolic blood pressure appeared to be determinants of apoB.

Citations

Citations to this article as recorded by  
  • Association of apolipoproteins and lipoprotein(a) with metabolic syndrome: a systematic review and meta-analysis
    Juan R. Ulloque-Badaracco, Ali Al-kassab-Córdova, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Miguel Huayta-Cortez, Ximena L. Carballo-Tello, Rosa A. Seminario-Amez, Percy Herrera-Añazco, Vicente A. Benites-Zapata
    Lipids in Health and Disease.2023;[Epub]     CrossRef
  • Current Data and New Insights into the Genetic Factors of Atherogenic Dyslipidemia Associated with Metabolic Syndrome
    Lăcramioara Ionela Butnariu, Eusebiu Vlad Gorduza, Elena Țarcă, Monica-Cristina Pânzaru, Setalia Popa, Simona Stoleriu, Vasile Valeriu Lupu, Ancuta Lupu, Elena Cojocaru, Laura Mihaela Trandafir, Ștefana Maria Moisă, Andreea Florea, Laura Stătescu, Minerva
    Diagnostics.2023; 13(14): 2348.     CrossRef
  • Apolipoprotein B compared with low-density lipoprotein cholesterol in the atherosclerotic cardiovascular diseases risk assessment
    Federica Galimberti, Manuela Casula, Elena Olmastroni
    Pharmacological Research.2023; 195: 106873.     CrossRef
  • Circulating lipids and breast cancer prognosis in the Malmö diet and cancer study
    Sixten Harborg, Thomas P. Ahern, Maria Feldt, Ann H. Rosendahl, Deirdre Cronin-Fenton, Olle Melander, Signe Borgquist
    Breast Cancer Research and Treatment.2022; 191(3): 611.     CrossRef
  • Metabolic disorders in patients with impaired glucose tolerance, with or without underlying ischaemic heart disease
    Milena Brkić, Danijel Đekić, Jelena Jovanić, Goran Topić, Aleksandra Grbić, Tatjana Šutilović
    Scripta Medica.2022; 53(3): 175.     CrossRef
  • Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence
    Sok Kuan Wong, Fitri Fareez Ramli, Adli Ali, Nurul ‘Izzah Ibrahim
    Biomedicines.2022; 10(12): 3239.     CrossRef
  • Prevalence of ApoB100 rs693 gene polymorphism in metabolic syndrome among female students at King Abdulaziz University
    Rana A. Alghamdi, Maryam H. Al-Zahrani, Maha J. Balgoon, Nuha A. Alkhattabi
    Saudi Journal of Biological Sciences.2021; 28(6): 3249.     CrossRef
  • Local ablation of gastric cancer by reconstituted apolipoprotein B lipoparticles carrying epigenetic drugs
    Chia-Lung Yang, Ying-Jui Chao, Hao-Chen Wang, Ya-Chin Hou, Caleb Gonshen Chen, Chia-Ching Chang, Yan-Shen Shan
    Nanomedicine: Nanotechnology, Biology and Medicine.2021; 37: 102450.     CrossRef
  • Cardiovascular Biomarkers of Obesity and Overlap With Cardiometabolic Dysfunction
    Emily S. Lau, Samantha M. Paniagua, Shahrooz Zarbafian, Udo Hoffman, Michelle T. Long, Shih‐Jen Hwang, Paul Courchesne, Chen Yao, Jiantao Ma, Martin G. Larson, Daniel Levy, Ravi V. Shah, Jennifer E. Ho
    Journal of the American Heart Association.2021;[Epub]     CrossRef
  • The association of ecg TV1>TV6 phenomenon as electrophysiological sign of metabolic myocardial disorders with risk factors for ischemic heart disease in the population of 25–44 years
    N. A. Kuzminykh, L. V. Shcherbakova, V. S. Shramko, D. V. Denisova, Yu. I. Ragino
    Ateroscleroz.2021; 17(2): 22.     CrossRef
  • Regulation of Apolipoprotein B by Natural Products and Nutraceuticals: A Comprehensive Review
    Mohammad Bagherniya, Thomas P. Johnston, Amirhossein Sahebkar
    Current Medicinal Chemistry.2021; 28(7): 1363.     CrossRef
  • Apolipoprotein B and non-high-density lipoprotein cholesterol reveal a high atherogenicity in individuals with type 2 diabetes and controlled low-density lipoprotein-cholesterol
    Liliana Fonseca, Sílvia Paredes, Helena Ramos, José Carlos Oliveira, Isabel Palma
    Lipids in Health and Disease.2020;[Epub]     CrossRef
  • Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women
    Seong-Hee Ko, Hyun-Sook Kim
    Nutrients.2020; 12(1): 202.     CrossRef
  • Lipoprotein A, combined with alanine aminotransferase and aspartate aminotransferase, contributes to predicting the occurrence of NASH: a cross-sectional study
    Yu Zhang, He He, Yu-Ping Zeng, Li-Dan Yang, Dan Jia, Zhen-Mei An, Wei-Guo Jia
    Lipids in Health and Disease.2020;[Epub]     CrossRef
  • Novel and traditional lipid profiles in Metabolic Syndrome reveal a high atherogenicity
    Sílvia Paredes, Liliana Fonseca, Laura Ribeiro, Helena Ramos, José Carlos Oliveira, Isabel Palma
    Scientific Reports.2019;[Epub]     CrossRef
  • Serum apolipoprotein B is associated with increased risk of metabolic syndrome among middle‐aged and elderly Chinese: A cross‐sectional and prospective cohort study
    Rui Du, Xueyan Wu, Kui Peng, Lin Lin, Mian Li, Yu Xu, Min Xu, Yuhong Chen, Donghui Li, Jieli Lu, Yufang Bi, Weiqing Wang, Guang Ning
    Journal of Diabetes.2019; 11(9): 752.     CrossRef
  • The role of metabolism disorders, inflammation, myocardial injury in development chronic heart failure in metabolic syndrome patients
    A. P. Roytman, T. A. Fedorova, E. A. Ivanova, A. V. Bugrov, V. V. Dolgov
    Laboratornaya sluzhba.2018; 7(4): 5.     CrossRef
  • Serum apoB levels independently predict the development of non‐alcoholic fatty liver disease: A 7‐year prospective study
    Jinghua Wang, Wanlin Zhu, Shujun Huang, Lei Xu, Min Miao, Chenjiao Wu, Chaohui Yu, Youming Li, Chengfu Xu
    Liver International.2017; 37(8): 1202.     CrossRef
  • Comprehensive assessment of lipoprotein subfraction profiles according to glucose metabolism status, and association with insulin resistance in subjects with early-stage impaired glucose metabolism
    Jie-Eun Lee, Se Hee Min, Dong-Hwa Lee, Tae Jung Oh, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Soo Lim
    International Journal of Cardiology.2016; 225: 327.     CrossRef
  • Association of Serum Apolipoprotein B with the Increased Risk of Diabetes in Korean Men
    Hyo Hee Lim, Oh Yoen Kim
    Clinical Nutrition Research.2016; 5(3): 204.     CrossRef
Close layer
Brief Report
Obesity and Metabolism
Glucagon-Like Peptide-1 Increases Mitochondrial Biogenesis and Function in INS-1 Rat Insulinoma Cells
Mi Yeon Kang, Tae Jung Oh, Young Min Cho
Endocrinol Metab. 2015;30(2):216-220.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.216
  • 3,786 View
  • 41 Download
  • 40 Web of Science
  • 38 Crossref
AbstractAbstract PDFPubReader   

Glucagon-like peptide-1 (GLP-1) is a gut-derived incretin hormone that increases glucose-stimulated insulin secretion in pancreatic β-cells. Since mitochondrial function is crucial to insulin secretion, we hypothesized that GLP-1 may increase mitochondrial biogenesis in pancreatic β-cells. We treated INS-1 rat insulinoma cells with GLP-1 or exendin-4 for 48 hours and measured mitochondrial mass and function. Both GLP-1 and exendin-4 increased mitochondrial mass by approximately 20%. The mitochondria/cytosol ratio was increased from 7.60±3.12% to 10.53±2.70% by exendin-4. In addition, GLP-1 increased the mitochondrial membrane potential and oxygen consumption. Proliferator-activated receptor-gamma coactivator 1α expression was increased approximately 2-fold by GLP-1 treatment. In conclusion, the present study presents evidence for a new mechanism of action by which GLP-1 improves pancreatic β-cell function via enhanced mitochondrial mass and performance.

Citations

Citations to this article as recorded by  
  • New fraternine analogues: Evaluation of the antiparkinsonian effect in the model of Parkinson's disease
    Andréia Biolchi Mayer, Henrique de Oliveira Amaral, Danilo Gustavo R. de Oliveira, Gabriel Avohay Alves Campos, Priscilla Galante Ribeiro, Solange Cristina Rego Fernandes, Adolfo Carlos Barros de Souza, Raffael Júnio Araújo de Castro, Anamélia Lorenzetti
    Neuropeptides.2024; 103: 102390.     CrossRef
  • Liraglutide demonstrates a therapeutic effect on mitochondrial dysfunction in human SGBS adipocytes in vitro
    Maija Vaittinen, Mariana Ilha, Elena Herbers, Anita Wagner, Kirsi A. Virtanen, Kirsi H. Pietiläinen, Eija Pirinen, Jussi Pihlajamäki
    Diabetes Research and Clinical Practice.2023; 199: 110635.     CrossRef
  • The cardioprotective effect of human glucagon‐like peptide‐1 receptor agonist (semaglutide) on cisplatin‐induced cardiotoxicity in rats: Targeting mitochondrial functions, dynamics, biogenesis, and redox status pathways
    Marwa Mohamed Atef, Yasser Mostafa Hafez, Omnia Safwat El‐Deeb, Eman H. Basha, Radwa Ismail, Hanan Alshenawy, Rasha Osama El‐Esawy, Amira Kamel Eltokhy
    Cell Biochemistry and Function.2023; 41(4): 450.     CrossRef
  • Targeting mitochondrial quality control for diabetic cardiomyopathy: Therapeutic potential of hypoglycemic drugs
    Yutong Zhou, Wendong Suo, Xinai Zhang, Jiaojiao Liang, Weizhe Zhao, Yue Wang, Hong Li, Qing Ni
    Biomedicine & Pharmacotherapy.2023; 168: 115669.     CrossRef
  • Soft X-ray tomography to map and quantify organelle interactions at the mesoscale
    Valentina Loconte, Jitin Singla, Angdi Li, Jian-Hua Chen, Axel Ekman, Gerry McDermott, Andrej Sali, Mark Le Gros, Kate L. White, Carolyn A. Larabell
    Structure.2022; 30(4): 510.     CrossRef
  • Comparisons of pleiotropic effects of SGLT2 inhibition and GLP-1 agonism on cardiac glucose intolerance in heart dysfunction
    Belma Turan, Aysegul Durak, Yusuf Olgar, Erkan Tuncay
    Molecular and Cellular Biochemistry.2022; 477(11): 2609.     CrossRef
  • Modulation of Reactive Oxygen Species Homeostasis as a Pleiotropic Effect of Commonly Used Drugs
    Carolin Thomas, Lia Wurzer, Ernst Malle, Michael Ristow, Corina T. Madreiter-Sokolowski
    Frontiers in Aging.2022;[Epub]     CrossRef
  • Anti-cancer effects of sitagliptin, vildagliptin, and exendin-4 on triple-negative breast cancer cells via mitochondrial modulation
    POOJA JAISWAL, VERSHA TRIPATHI, ANSHUL ASSAIYA, DHARMENDRA KASHYAP, RAHUL DUBEY, ANAMIKA SINGH, JANESH KUMAR, HEM CHANDRA JHA, RAJESH SHARMA, AMIT KUMAR DIXIT, HAMENDRA SINGH PARMAR
    BIOCELL.2022; 46(12): 2645.     CrossRef
  • Effect of liraglutide on neural and peripheral markers of metabolic function during antipsychotic treatment in rats
    Ilijana Babic, Dominic Sellers, Paul L Else, Jessica Nealon, Ashleigh L Osborne, Nagesh Pai, Katrina Weston-Green
    Journal of Psychopharmacology.2021; 35(3): 284.     CrossRef
  • Sustained Release GLP-1 Agonist PT320 Delays Disease Progression in a Mouse Model of Parkinson’s Disease
    Vicki Wang, Tung-Tai Kuo, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Yu-Ching Chou, Zhao-Yang Fu, Li-Wen Lai, Jin Jung, Hoi-II Choi, Doo-Sup Choi, Yazhou Li, Lars Olson, Nigel H. Greig, Barry J. Hoffer, Yuan-Hao Chen
    ACS Pharmacology & Translational Science.2021; 4(2): 858.     CrossRef
  • Antioxidative Potentials of Incretin-Based Medications: A Review of Molecular Mechanisms
    Habib Yaribeygi, Mina Maleki, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar, Marina Sokovi
    Oxidative Medicine and Cellular Longevity.2021; 2021: 1.     CrossRef
  • Vernicia fordii (Hemsl.) Airy Shaw extract stimulates insulin secretion in pancreatic β-cells and improves insulin sensitivity in diabetic mice
    Jimin Hyun, Mi Hyeon Park, Yo Han Lee, Youngeun Lee, Su Ji Jeong, Sun Sil Choi, Keon Woo Khim, Hye Jin Eom, Jin-Hoe Hur, Chan Young Park, Jae-Ick Kim, Jiyoung Park, Hyung Won Ryu, Hyun-Jun Jang, Sei-Ryang Oh, Jang Hyun Choi
    Journal of Ethnopharmacology.2021; 278: 114238.     CrossRef
  • Connecting the dots between mitochondrial dysfunction and Parkinson’s disorder: focus mitochondria-targeting therapeutic paradigm in mitigating the disease severity
    Ishnoor Kaur, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Lotfi Aleya, Simona Bungau
    Environmental Science and Pollution Research.2021; 28(28): 37060.     CrossRef
  • Neuromodulatory effects of anti-diabetes medications: A mechanistic review
    Habib Yaribeygi, Milad Ashrafizadeh, Neil C. Henney, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar
    Pharmacological Research.2020; 152: 104611.     CrossRef
  • Antidiabetic Agents for Treatment of Parkinson’s Disease: A Meta-Analysis
    Shu-Yi Wang, Shey-Lin Wu, Ta-Cheng Chen, Chieh-Sen Chuang
    International Journal of Environmental Research and Public Health.2020; 17(13): 4805.     CrossRef
  • Visualizing subcellular rearrangements in intact β cells using soft x-ray tomography
    Kate L. White, Jitin Singla, Valentina Loconte, Jian-Hua Chen, Axel Ekman, Liping Sun, Xianjun Zhang, John Paul Francis, Angdi Li, Wen Lin, Kaylee Tseng, Gerry McDermott, Frank Alber, Andrej Sali, Carolyn Larabell, Raymond C. Stevens
    Science Advances.2020;[Epub]     CrossRef
  • Nutrient Sensor mTOR and OGT: Orchestrators of Organelle Homeostasis in Pancreatic β-Cells
    Nicholas Esch, Seokwon Jo, Mackenzie Moore, Emilyn U. Alejandro, Yingke Xu
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • Metabolic dynamics of human Sertoli cells are differentially modulated by physiological and pharmacological concentrations of GLP-1
    Ana D. Martins, Mariana P. Monteiro, Branca M. Silva, Alberto Barros, Mário Sousa, Rui A. Carvalho, Pedro F. Oliveira, Marco G. Alves
    Toxicology and Applied Pharmacology.2019; 362: 1.     CrossRef
  • Sarcopenia in Chronic Kidney Disease: Factors, Mechanisms, and Therapeutic Interventions
    Hiroshi Watanabe, Yuki Enoki, Toru Maruyama
    Biological and Pharmaceutical Bulletin.2019; 42(9): 1437.     CrossRef
  • Recent Advances in Drug Repurposing for Parkinson’s Disease
    Xin Chen, Giuseppe Gumina, Kristopher G. Virga
    Current Medicinal Chemistry.2019; 26(28): 5340.     CrossRef
  • Mitochondrial dysfunction in diabetes and the regulatory roles of antidiabetic agents on the mitochondrial function
    Habib Yaribeygi, Stephen L. Atkin, Amirhossein Sahebkar
    Journal of Cellular Physiology.2019; 234(6): 8402.     CrossRef
  • Liraglutide protects against glucolipotoxicity‐induced RIN‐m5F β‐cell apoptosis through restoration of PDX1 expression
    Edy Kornelius, Hsin‐Hua Li, Chiung‐Huei Peng, Yi‐Sun Yang, Wei‐Jen Chen, Yan‐Zin Chang, Yi‐Chiao Bai, Stanley Liu, Chien‐Ning Huang, Chih‐Li Lin
    Journal of Cellular and Molecular Medicine.2019; 23(1): 619.     CrossRef
  • The osteogenic effect of liraglutide involves enhanced mitochondrial biogenesis in osteoblasts
    Subhashis Pal, Shailendra K. Maurya, Sourav Chattopadhyay, Shyamsundar Pal China, Konica Porwal, Chirag Kulkarni, Sabyasachi Sanyal, Rohit A. Sinha, Naibedya Chattopadhyay
    Biochemical Pharmacology.2019; 164: 34.     CrossRef
  • Novel Treatment Opportunities Against Cognitive Impairment in Parkinson’s Disease with an Emphasis on Diabetes-Related Pathways
    Holly Green, Panagiota Tsitsi, Ioanna Markaki, Dag Aarsland, Per Svenningsson
    CNS Drugs.2019; 33(2): 143.     CrossRef
  • Mitral cells and the glucagon‐like peptide 1 receptor: The sweet smell of success?
    Enrico Bagnoli, Una FitzGerald
    European Journal of Neuroscience.2019; 49(4): 422.     CrossRef
  • Targeting the DPP-4-GLP-1 pathway improves exercise tolerance in heart failure patients: a systematic review and meta-analysis
    Chengcong Chen, Ying Huang, Yongmei Zeng, Xiyan Lu, Guoqing Dong
    BMC Cardiovascular Disorders.2019;[Epub]     CrossRef
  • Acute exposure to 3‑deoxyglucosone at high glucose levels impairs insulin secretion from β‑cells by downregulating the sweet taste receptor signaling pathway
    Xiudao Song, Guoqiang Liang, Min Shi, Liang Zhou, Fei Wang, Lurong Zhang, Fei Huang, Guorong Jiang
    Molecular Medicine Reports.2019;[Epub]     CrossRef
  • Translational approaches to restoring mitochondrial function in Parkinson's disease
    Heather Mortiboys, Ruby Macdonald, Thomas Payne, Matilde Sassani, Thomas Jenkins, Oliver Bandmann
    FEBS Letters.2018; 592(5): 776.     CrossRef
  • Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy
    Eridan Rocha-Ferreira, Laura Poupon, Aura Zelco, Anna-Lena Leverin, Syam Nair, Andrea Jonsdotter, Ylva Carlsson, Claire Thornton, Henrik Hagberg, Ahad A Rahim
    Brain.2018; 141(10): 2925.     CrossRef
  • Current perspective of mitochondrial biology in Parkinson's disease
    Navneet Ammal Kaidery, Bobby Thomas
    Neurochemistry International.2018; 117: 91.     CrossRef
  • Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells
    Qingqing Qin, Jieqiong Jin, Fang He, Yongqin Zheng, Tingting Li, Yun Zhang, Jundong He
    Biochemical and Biophysical Research Communications.2018; 497(1): 292.     CrossRef
  • Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial
    Dilan Athauda, Kate Maclagan, Simon S Skene, Martha Bajwa-Joseph, Dawn Letchford, Kashfia Chowdhury, Steve Hibbert, Natalia Budnik, Luca Zampedri, John Dickson, Yazhou Li, Iciar Aviles-Olmos, Thomas T Warner, Patricia Limousin, Andrew J Lees, Nigel H Grei
    The Lancet.2017; 390(10103): 1664.     CrossRef
  • Alogliptin, a Dipeptidyl Peptidase‐4 Inhibitor, Alleviates Atrial Remodeling and Improves Mitochondrial Function and Biogenesis in Diabetic Rabbits
    Xiaowei Zhang, Zhiwei Zhang, Yungang Zhao, Ning Jiang, Jiuchun Qiu, Yajuan Yang, Jian Li, Xue Liang, Xinghua Wang, Gary Tse, Guangping Li, Tong Liu
    Journal of the American Heart Association.2017;[Epub]     CrossRef
  • Potential therapeutic interventions for chronic kidney disease‐associated sarcopenia via indoxyl sulfate‐induced mitochondrial dysfunction
    Yuki Enoki, Hiroshi Watanabe, Riho Arake, Rui Fujimura, Kana Ishiodori, Tadashi Imafuku, Kento Nishida, Ryusei Sugimoto, Saori Nagao, Shigeyuki Miyamura, Yu Ishima, Motoko Tanaka, Kazutaka Matsushita, Hirotaka Komaba, Masafumi Fukagawa, Masaki Otagiri, To
    Journal of Cachexia, Sarcopenia and Muscle.2017; 8(5): 735.     CrossRef
  • The pancreas: Bandmaster of glucose homeostasis
    Nathalie Jouvet, Jennifer L. Estall
    Experimental Cell Research.2017; 360(1): 19.     CrossRef
  • The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action
    Dilan Athauda, Thomas Foltynie
    Drug Discovery Today.2016; 21(5): 802.     CrossRef
  • Effects of addition of a dipeptidyl peptidase IV inhibitor to metformin on sirolimus-induced diabetes mellitus
    Long Jin, Sun Woo Lim, Jian Jin, Byung Ha Chung, Chul Woo Yang
    Translational Research.2016; 174: 122.     CrossRef
  • Pharmacological Modulators of Endoplasmic Reticulum Stress in Metabolic Diseases
    Tae Jung, Kyung Choi
    International Journal of Molecular Sciences.2016; 17(2): 192.     CrossRef
Close layer
Case Reports
Thyroid
A Calcitonin-Negative Neuroendocrine Tumor Derived from Follicular Lesions of the Thyroid
Ga Young Kim, Chul Yun Park, Chang Ho Cho, June Sik Park, Eui Dal Jung, Eon Ju Jeon
Endocrinol Metab. 2015;30(2):221-225.   Published online December 9, 2014
DOI: https://doi.org/10.3803/EnM.2015.30.2.221
  • 3,185 View
  • 29 Download
  • 7 Web of Science
  • 8 Crossref
AbstractAbstract PDFPubReader   

Neuroendocrine lesions of the thyroid are rare. The most common types are medullary thyroid carcinomas (MTCs) and C-cell hyperplasia. MTCs originate from thyroid parafollicular cells that secrete calcitonin which serves as a serum marker of MTCs. Here, the rare case of a calcitonin-negative neuroendocrine tumor (NET) derived from follicular lesions of the thyroid is described. A 34-year-old man presented at our hospital for the surgical management of an incidental thyroid nodule that was observed on an ultrasound sonography (USG) of the neck. Initially, USG-guided aspiration cytology was performed, and a MTC was suspected. The expressions of thyroglobulin and thyroid transcription factor-1, which are thyroid follicular cell markers, and synaptophysin and chromogranin A, which are neuroendocrine markers, was confirmed following surgical pathology. However, the staining of calcitonin, a marker of MTCs, was not observed. A nonmedullary NET of the thyroid is uncommon, and the distinction between calcitonin-negative NETs and MTCs of the thyroid may be important due to differences in their clinical courses and management.

Citations

Citations to this article as recorded by  
  • Calcitonin-Negative Neuroendocrine Carcinoma of the Thyroid Gland: Case Report and Literature Review
    Ricardo Fernández-Ferreira, Ildefonso Roberto De la Peña-López, Karla Walkiria Zamudio-Coronado, Luis Antonio Delgado-Soler, María Eugenia Torres-Pérez, Christianne Bourlón-de los Ríos, Rubén Cortés-González
    Case Reports in Oncology.2021; 14(1): 112.     CrossRef
  • Calcitonin-negative neuroendocrine tumor of the thyroid with metastasis to liver-rare presentation of an unusual tumor: A case report and review of literature
    Huai-Jie Cai, Han Wang, Nan Cao, Bin Huang, Fan-Lei Kong, Li-Ren Lu, Ya-Yuan Huang, Wei Wang
    World Journal of Clinical Cases.2020; 8(1): 179.     CrossRef
  • Medullary thyroid carcinoma with double negative calcitonin and CEA: a case report and update of literature review
    Claudio Gambardella, Chiara Offi, Guglielmo Clarizia, Roberto Maria Romano, Immacolata Cozzolino, Marco Montella, Rosa Maria Di Crescenzo, Massimo Mascolo, Angelo Cangiano, Sergio Di Martino, Giancarlo Candela, Giovanni Docimo
    BMC Endocrine Disorders.2019;[Epub]     CrossRef
  • Calcitonin negative Medullary Thyroid Carcinoma: a challenging diagnosis or a medical dilemma?
    Claudio Gambardella, Chiara Offi, Renato Patrone, Guglielmo Clarizia, Claudio Mauriello, Ernesto Tartaglia, Francesco Di Capua, Sergio Di Martino, Roberto Maria Romano, Lorenzo Fiore, Alessandra Conzo, Giovanni Conzo, Giovanni Docimo
    BMC Endocrine Disorders.2019;[Epub]     CrossRef
  • Calcitonin-Negative Neuroendocrine Tumor of the Thyroid
    Megan Parmer, Stacey Milan, Alireza Torabi
    International Journal of Surgical Pathology.2017; 25(2): 191.     CrossRef
  • Clinical and pathological analysis of 19 cases of medullary thyroid carcinoma without an increase in calcitonin
    Qiufeng Zhou, Shuanglei Yue, Ye Cheng, Ju Jin, Haimiao Xu
    Experimental and Toxicologic Pathology.2017; 69(8): 575.     CrossRef
  • Primary Calcitonin-negative Neuroendocrine Tumor
    Sabri Özden, Aysel Colak, Baris Saylam, Ömer Cengiz
    World Journal of Endocrine Surgery.2017; 9(3): 104.     CrossRef
  • LONG-TERM RESULTS OF SURGICAL TREATMENT OF PATIENTS WITH FOLLICULAR TUMORS OF THE THYROID
    I. N. Zubarovskiy, M. V. Mikhailova, S. K. Osipenko
    Grekov's Bulletin of Surgery.2015; 174(5): 32.     CrossRef
Close layer
Partial Androgen Insensitivity Syndrome Presenting with Gynecomastia
Sung Won Lee, Dong Shin Kwak, In Sub Jung, Joo Hee Kwak, Jung Hwan Park, Sang Mo Hong, Chang Bum Lee, Yong Soo Park, Dong Sun Kim, Woong Hwan Choi, You Hern Ahn
Endocrinol Metab. 2015;30(2):226-230.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.226
  • 6,395 View
  • 68 Download
  • 4 Web of Science
  • 5 Crossref
AbstractAbstract PDFPubReader   

Gynecomastia is a benign enlargement of the male breast caused by the proliferation of glandular breast tissue. Determining the various causes of gynecomastia such as physiological causes, drugs, systemic diseases, and endocrine disorders is important. Androgen insensitivity syndrome (AIS) is a rare endocrine disorder presenting with gynecomastia and is a disorder of male sexual differentiation caused by mutations within the androgen receptor gene. All individuals with AIS have the 46 XY karyotype, although AIS phenotypes can be classified as mild, partial or complete and can differ among both males and females including ambiguous genitalia or infertility in males. We experienced a case of partial AIS presenting with gynecomastia and identified the androgen receptor gene mutation.

Citations

Citations to this article as recorded by  
  • Clinical outcomes and genotype-phenotype correlations in patients with complete and partial androgen insensitivity syndromes
    Nae-yun Lee, Ja Hye Kim, Ji-Hee Yoon, Soojin Hwang, Gu-Hwan Kim, Han-Wook Yoo, Jin-Ho Choi
    Annals of Pediatric Endocrinology & Metabolism.2023; 28(3): 184.     CrossRef
  • The Impact and Management of Gynaecomastia in Klinefelter Syndrome
    Amr Abdel Raheem, Ahmed Said Zaghloul, Ahmed M. G. Sadek, Bilal Rayes, Tarek M. Abdel-Raheem
    Frontiers in Reproductive Health.2021;[Epub]     CrossRef
  • Identification of Potential Genes in Pathogenesis and Diagnostic Value Analysis of Partial Androgen Insensitivity Syndrome Using Bioinformatics Analysis
    Yajie Peng, Hui Zhu, Bing Han, Yue Xu, Xuemeng Liu, Huaidong Song, Jie Qiao
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Adolescent Gynecomastia due to Minimal Androgen Resistance Syndrome: A Case Report and Literature Review
    Aureliano Fiorini, Margherita Sepich, Margherita Pontrelli, Giorgio Sangriso, Mirna Cosci o Di Coscio, Marcella Lauletta, Fulvia Baldinotti, Diego Peroni, Maria Rosaria Ambrosio, Silvano Bertelloni
    Sexual Development.2020; 14(1-6): 21.     CrossRef
  • Endocrine and molecular investigations in a cohort of 25 adolescent males with prominent/persistent pubertal gynecomastia
    F. Paris, L. Gaspari, F. Mbou, P. Philibert, F. Audran, Y. Morel, A. Biason‐Lauber, C. Sultan
    Andrology.2016; 4(2): 263.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism