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Volume 25(4); December 2010
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Review Articles
Biological Rhythms and Neuroendocrine Systems.
Gi Hoon Son, Sooyoung Chung, Kyungjin Kim
Endocrinol Metab. 2010;25(4):249-257.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.249
  • 2,070 View
  • 69 Download
  • 4 Crossref
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No abstract available.

Citations

Citations to this article as recorded by  
  • UP165, standardized corn leaf extract and its active component 6-methoxybenzoxazolinone induce non-rapid eye movement sleep through melatonergic and GABAergic mechanisms
    Hyun Jin Kim, Hyeongyeong Kim, Young Jun Kim, Seon Gil Do, Hyung Joo Suh, Yeok Boo Chang, Hyowon Lee
    Food Bioscience.2024; 61: 104584.     CrossRef
  • Circadian Rhythm and Health : Influence of Food Intake Timing and Regular Exercise
    Kyung-won Lee, Seung Kyum Kim
    Korean Journal of Sport Science.2023; 34(2): 187.     CrossRef
  • Development of a natural light reproduction system for maintaining the circadian rhythm
    Kyeong-Mi Kim, Young-Won Kim, Seung-Taek Oh, Jae-Hyun Lim
    Indoor and Built Environment.2020; 29(1): 132.     CrossRef
  • Effect of Mefloquine, a Gap Junction Blocker, on Circadian Period2 Gene Oscillation in the Mouse Suprachiasmatic NucleusEx Vivo
    Jinmi Koo, Han Kyoung Choe, Hee-Dae Kim, Sung Kook Chun, Gi Hoon Son, Kyungjin Kim
    Endocrinology and Metabolism.2015; 30(3): 361.     CrossRef
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Ghrelin.
Seungjoon Park
Endocrinol Metab. 2010;25(4):258-263.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.258
  • 1,910 View
  • 29 Download
  • 3 Crossref
AbstractAbstract PDF
No abstract available.

Citations

Citations to this article as recorded by  
  • Circadian Rhythm and Health : Influence of Food Intake Timing and Regular Exercise
    Kyung-won Lee, Seung Kyum Kim
    Korean Journal of Sport Science.2023; 34(2): 187.     CrossRef
  • Association between cancer metabolism and muscle atrophy
    Yeonju Seo, Ju-Ock Nam
    Journal of Applied Biological Chemistry.2022; 65(4): 387.     CrossRef
  • Effect of Ghrelin on Memory Impairment in a Rat Model of Vascular Dementia
    Jong-Min Park, Youn-Jung Kim
    Journal of Korean Academy of Nursing.2019; 49(3): 317.     CrossRef
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Molecular Understanding of Osteoclast Differentiation and Physiology.
Na Kyung Lee
Endocrinol Metab. 2010;25(4):264-269.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.264
  • 2,379 View
  • 55 Download
  • 14 Crossref
AbstractAbstract PDF
No abstract available.

Citations

Citations to this article as recorded by  
  • Sclareol inhibits RANKL-induced osteoclastogenesis and promotes osteoblastogenesis through promoting CCN1 expression via repressing the MAPK pathway
    Xiang Li, Yuxin Wang, Liangping Li, Shengji Zhou, Fengchao Zhao
    Cell Biology and Toxicology.2021; 37(6): 849.     CrossRef
  • The Role of Osteoclast Energy Metabolism in the Occurrence and Development of Osteoporosis
    Wacili Da, Lin Tao, Yue Zhu
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Targeted proteomic response to coffee consumption
    Alan Kuang, Iris Erlund, Christian Herder, Johan A. Westerhuis, Jaakko Tuomilehto, Marilyn C. Cornelis
    European Journal of Nutrition.2020; 59(4): 1529.     CrossRef
  • Smart Nanosacrificial Layer on the Bone Surface Prevents Osteoporosis through Acid–Base Neutralization Regulated Biocascade Effects
    Xianfeng Lin, Qingqing Wang, Chenhui Gu, Mobai Li, Kai Chen, Pengfei Chen, Zhibin Tang, Xin Liu, Haihua Pan, Zhaoming Liu, Ruikang Tang, Shunwu Fan
    Journal of the American Chemical Society.2020; 142(41): 17543.     CrossRef
  • Inhibition of osteoclastogenesis by mechanically stimulated osteoblasts is attenuated during estrogen deficiency
    H. Allison, L. M. McNamara
    American Journal of Physiology-Cell Physiology.2019; 317(5): C969.     CrossRef
  • Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases
    Taiwo Samuel Agidigbi, Chaekyun Kim
    International Journal of Molecular Sciences.2019; 20(14): 3576.     CrossRef
  • Targeted delivery of p-coumaric acid encapsulated mannosylated liposomes to the synovial macrophages inhibits osteoclast formation and bone resorption in the rheumatoid arthritis animal model
    Manoj Kumar Neog, Mahaboobkhan Rasool
    European Journal of Pharmaceutics and Biopharmaceutics.2018; 133: 162.     CrossRef
  • Bone resorptive activity of human peripheral blood mononuclear cells after fusion with polyethylene glycol
    Edwin Manrique, Luz M. Castillo, Oswaldo Lazala, Carlos A. Guerrero, Orlando Acosta
    Journal of Bone and Mineral Metabolism.2017; 35(2): 127.     CrossRef
  • Effects of Pulsed Electromagnetic Fields of Different Frequencies on the Gene Expression of RANK and NFATc1 in Rat Osteoclasts Co-Cultured with Osteoblasts
    Jian Chen, Hui Huang, Jianquan He, Zhang Xin
    Journal of Biomedical Science and Engineering.2017; 10(01): 21.     CrossRef
  • Characterization of MicroRNA Expression Profiles in Patients with Giant Cell Tumor
    Shu Qin, Neng‐bin He, Hong‐liang Yan, Yang Dong
    Orthopaedic Surgery.2016; 8(2): 212.     CrossRef
  • Cyclolinopeptides, cyclic peptides from flaxseed with osteoclast differentiation inhibitory activity
    Toshio Kaneda, Haruka Yoshida, Yuki Nakajima, Minako Toishi, Alfarius Eko Nugroho, Hiroshi Morita
    Bioorganic & Medicinal Chemistry Letters.2016; 26(7): 1760.     CrossRef
  • Commercial Honeybush (Cyclopia spp.) Tea Extract Inhibits Osteoclast Formation and Bone Resorption in RAW264.7 Murine Macrophages—An in vitro Study
    Amcois Visagie, Abe Kasonga, Vishwa Deepak, Shaakirah Moosa, Sumari Marais, Marlena Kruger, Magdalena Coetzee
    International Journal of Environmental Research and Public Health.2015; 12(11): 13779.     CrossRef
  • Chrotacumines G–J, chromone alkaloids from Dysoxylum acutangulum with osteoclast differentiation inhibitory activity
    Hiroshi Morita, Alfarius Eko Nugroho, Yuta Nagakura, Yusuke Hirasawa, Haruka Yoshida, Toshio Kaneda, Osamu Shirota, Intan Safinar Ismail
    Bioorganic & Medicinal Chemistry Letters.2014; 24(11): 2437.     CrossRef
  • Caffeine enhances osteoclast differentiation and maturation through p38 MAP kinase/Mitf and DC-STAMP/CtsK and TRAP pathway
    Jiwon Choi, So Yoen Choi, Sun Young Lee, Jae Yoon Lee, Hong Sung Kim, Soo Young Lee, Na Kyung Lee
    Cellular Signalling.2013; 25(5): 1222.     CrossRef
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Revised Korean Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Thyroid Cancer.
Ka Hee Yi, Young Joo Park, Sung Soo Koong, Jung Han Kim, Dong Gyu Na, Jin Sook Ryu, So Yeon Park, In Ae Park, Chung Hwan Baek, Young Kee Shong, Young Don Lee, Jaetae Lee, Jeong Hyun Lee, Jae Hoon Chung, Chan Kwon Jung, Seung Ho Choi, Bo Youn Cho
Endocrinol Metab. 2010;25(4):270-297.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.270
  • 3,866 View
  • 45 Download
  • 36 Crossref
AbstractAbstract PDF
No abstract available.

Citations

Citations to this article as recorded by  
  • Thyroid Cancer Incidence Among Korean Individuals: A Comparison of South Korea and the United States
    Dohun Kim, Guan Li, Peter K. Moon, Yifei Ma, Soohyun Sim, Sung Y. Park, Minkyung Oh, Uchechukwu C. Megwalu
    The Laryngoscope.2024; 134(9): 4156.     CrossRef
  • Imaging Recommendations for Diagnosis, Staging, and Management of Cancer of the Thyroid, Parathyroid, and Salivary Glands
    Abhishek Mahajan, Shreya Shukla, Suman Kumar Ankathi, Anuradha Shukla, Richa Vaish, Shubham Suryavanshi, Ujjwal Agarwal, Vasundhara Patil, Arpita Sahu, Shubham Padashetty, Sarbani Ghosh Laskar, Vijay Patil, Vanita Noronha, Nandini Menon, Kumar Prabhash, A
    Indian Journal of Medical and Paediatric Oncology.2023; 44(02): 159.     CrossRef
  • Authors’ Reply: A Time Trend Analysis of 5000 Robotic Thyroidectomies via Bilateral Axillo‐Breast Approach
    JungHak Kwak, Hyeong Won Yu, Jong‐hyuk Ahn, Su‐jin Kim, Young Jun Chai, June Young Choi, Kyu Eun Lee
    World Journal of Surgery.2023; 47(8): 2086.     CrossRef
  • 2023 Korean Thyroid Association Management Guidelines for Patients with Thyroid Nodules
    Young Joo Park, Eun Kyung Lee, Young Shin Song, Soo Hwan Kang, Bon Seok Koo, Sun Wook Kim, Dong Gyu Na, Seung-Kuk Baek, So Won Oh, Min Kyoung Lee, Sang-Woo Lee, Young Ah Lee, Yong Sang Lee, Ji Ye Lee, Dong-Jun Lim, Leehi Joo, Yuh-Seog Jung, Chan Kwon Jung
    International Journal of Thyroidology.2023; 16(1): 1.     CrossRef
  • Optimization of the design parameters for a thyroid care nuclide monitoring diverging collimator using Monte Carlo simulation
    Dong-Hee Han, Seung-Jae Lee, Jang-Oh Kim, Da-Eun Kwon, Kyung-Hwan Jung, Cheol-Ha Baek
    Journal of the Korean Physical Society.2022; 81(7): 675.     CrossRef
  • Active Surveillance for Papillary Thyroid Microcarcinoma in a Population with Restrictive Diagnostic Workup Strategies
    Ivona Lončar, Sam P.J. van Dijk, Madelon J.H. Metman, Jia Feng Lin, Schelto Kruijff, Robin P. Peeters, Anton F. Engelsman, Tessa M. van Ginhoven
    Thyroid.2021; 31(8): 1219.     CrossRef
  • Decreasing trends in thyroid cancer incidence in South Korea: What happened in South Korea?
    Chang‐Mo Oh, Jiwon Lim, Yuh Seog Jung, Yeol Kim, Kyu‐Won Jung, Seri Hong, Young‐Joo Won
    Cancer Medicine.2021; 10(12): 4087.     CrossRef
  • Efficacy of Differential Diagnosis of Thyroid Nodules by Shear Wave Elastography—the Stiffness Map
    Myung Hi Yoo, Hye Jeong Kim, In Ho Choi, Suyeon Park, Sumi Yun, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh
    Journal of the Endocrine Society.2021;[Epub]     CrossRef
  • Spatial distribution and determinants of thyroid cancer incidence from 1999 to 2013 in Korea
    Jieun Jang, Dae-Sung Yoo, Byung Chul Chun
    Scientific Reports.2021;[Epub]     CrossRef
  • Income differences in screening, incidence, postoperative complications, and mortality of thyroid cancer in South Korea: a national population-based time trend study
    Hee-Yeon Kang, Ikhan Kim, Yeon-Yong Kim, Jinwook Bahk, Young-Ho Khang
    BMC Cancer.2020;[Epub]     CrossRef
  • Differential Diagnosis of Thyroid Follicular Neoplasm from Nodular Hyperplasia by Shear Wave Elastography
    Myung Hi Yoo, Hye Jeong Kim, In Ho Choi, Ji-Oh Mok, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh
    Soonchunhyang Medical Science.2019; 25(1): 10.     CrossRef
  • Diagnostic Performance of Shear Wave Elastography as Add-on Test in Thyroid Nodules: a Systematic Review and Meta-Analysis
    Sun-young Park, Ji Yang Song, Min Jin Lee, Kyung Min Lee, Mi Hye Jeon, Ryeo Jin Ko, Seok-Hyun Kim, Bong Joo Kang
    International Journal of Thyroidology.2018; 11(1): 31.     CrossRef
  • Structural Equation Modeling on Health-related Quality of Life among Patients with Thyroid Cancer
    Seon Young Lee, Hyun Kyung Kim
    Korean Journal of Adult Nursing.2018; 30(2): 171.     CrossRef
  • Prevalence and Annual Incidence of Thyroid Disease in Korea from 2006 to 2015: A Nationwide Population-Based Cohort Study
    Hyemi Kwon, Jin-hyung Jung, Kyung-Do Han, Yong-Gyu Park, Jung-Hwan Cho, Da Young Lee, Ji Min Han, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
    Endocrinology and Metabolism.2018; 33(2): 260.     CrossRef
  • Ten Years of the Korean Thyroid Association: Achievement and Future
    Young Joo Park, Young Shin Song, Ka Hee Yi
    International Journal of Thyroidology.2018; 11(1): 1.     CrossRef
  • Prediction of Contralateral Occult Malignant Nodule in Patients with Unilaterally Confined Papillary Thyroid Carcinomas
    Sang Wook Jo, Ha Kyoung Park, Tae Kwun Ha
    Journal of Endocrine Surgery.2018; 18(3): 191.     CrossRef
  • Surgical Treatment Guidelines for Patients with Differentiated Thyroid Cancer: The Korean Association of Thyroid and Endocrine Surgeons (KATES) Guidelines Taskforce
    Jin-Woo Park, Ki-Wook Chung, Ji-Sup Yun, Hyungju Kwon, Hoon Yub Kim, Kee Hyun Nam, Kyoung Sik Park, Min Ho Park, Ja Sung Bae, Hyun Jo Youn, Kyu Eun Lee, Chi Young Lim, Jin Hyang Jung, Jun-Ho Choe, Lee Su Kim, Su Jung Lee, Jung Han Yoon
    Korean Journal of Endocrine Surgery.2017; 17(1): 1.     CrossRef
  • Thyroid fine-needle aspiration biopsy positively correlates with increased diagnosis of thyroid cancer in South Korean patients
    Yoon Jae Cho, Do Young Kim, Eun-Cheol Park, Kyu-Tae Han
    BMC Cancer.2017;[Epub]     CrossRef
  • Current trends of practical issues concerning micropapillary thyroid carcinoma
    Yoon Se Lee, Byung-Joo Lee, Hyun Joon Hong, Kang-Dae Lee
    Medicine.2017; 96(45): e8596.     CrossRef
  • The Use of the Bethesda System for Reporting Thyroid Cytopathology in Korea: A Nationwide Multicenter Survey by the Korean Society of Endocrine Pathologists
    Mimi Kim, Hyo Jin Park, Hye Sook Min, Hyeong Ju Kwon, Chan Kwon Jung, Seoung Wan Chae, Hyun Ju Yoo, Yoo Duk Choi, Mi Ja Lee, Jeong Ja Kwak, Dong Eun Song, Dong Hoon Kim, Hye Kyung Lee, Ji Yeon Kim, Sook Hee Hong, Jang Sihn Sohn, Hyun Seung Lee, So Yeon Pa
    Journal of Pathology and Translational Medicine.2017; 51(4): 410.     CrossRef
  • Does the Risk of Metabolic Syndrome Increase in Thyroid Cancer Survivors?
    Min-Hee Kim, Jin-young Huh, Dong-jun Lim, Moo-Il Kang
    Thyroid.2017; 27(7): 936.     CrossRef
  • Surgical Treatment Guidelines for Patients with Differentiated Thyroid Cancer: The Korean Association of Thyroid and Endocrine Surgeons (KATES) Guidelines Taskforce
    Jin-Woo Park, Ki-Wook Chung, Ji-Sup Yun, Hyungju Kwon, Hoon Yub Kim, Kee Hyun Nam, Kyoung Sik Park, Min Ho Park, Ja Sung Bae, Hyun Jo Youn, Kyu Eun Lee, Chi Young Lim, Jin Hyang Jung, Jun-Ho Choe, Lee Su Kim, Su Jung Lee, Jung Han Yoon
    Korean Journal of Endocrine Surgery.2017; 17(1): 1.     CrossRef
  • Incidental Detection of Struma Ovarii on the Whole Body Scan in a Differentiated Thyroid Cancer Patient
    Hye-Seon Oh, Eyun Song, Dong Eun Song, Won Bae Kim
    International Journal of Thyroidology.2016; 9(2): 180.     CrossRef
  • The Experience of Receiving Radioactive Iodine Therapy among Thyroid Cancer Patients
    Kyung Ok Kang, Hyun Kyung Kim, Ji Young Kim, Seok Tae Lim
    Journal of East-West Nursing Research.2016; 22(2): 148.     CrossRef
  • Comparison of two- and three-dimensional sonography for the prediction of the extrathyroidal extension of papillary thyroid carcinomas
    Yang Seon Yi, Sang Soo Kim, Won Jin Kim, Min Jung Bae, Ji Hyun Kang, Bo Gwang Choi, Yun Kyung Jeon, Bo Hyun Kim, Byung Joo Lee, Soo Geun Wang, In Joo Kim, Yong Ki Kim
    The Korean Journal of Internal Medicine.2016; 31(2): 313.     CrossRef
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    Yong Sang Lee, Hang-Seok Chang, Cheong Soo Park
    Endocrine Journal.2016; 63(6): 515.     CrossRef
  • Low Dose versus High Dose Radioiodine Therapy
    Kyoung Sook Won
    Journal of Korean Thyroid Association.2015; 8(1): 14.     CrossRef
  • History of Korean Thyroid Association and Recent Debates on Diagnosis and Treatment of Thyroid Cancer in Korea
    Kwang Woo Lee
    Journal of Korean Thyroid Association.2015; 8(1): 36.     CrossRef
  • Lowered cutoff of lymph node fine-needle aspiration thyroglobulin in thyroid cancer patients with serum anti-thyroglobulin antibody
    Kwanhoon Jo, Min-Hee Kim, Yejee Lim, So-Lyung Jung, Ja-Seong Bae, Chan-Kwon Jung, Moo-Il Kang, Bong-Yun Cha, Dong-Jun Lim
    European Journal of Endocrinology.2015; 173(4): 489.     CrossRef
  • Time Trends Analysis of Characteristics of Patients with Thyroid Cancer in a Single Medical Center
    Hyung Seo Jung, Min Ji Jeon, Dong Eun Song, Suck Joon Hong, Won Gu Kim, Tae Yong Kim, Young Kee Shong, Won Bae Kim
    Journal of Korean Thyroid Association.2014; 7(2): 159.     CrossRef
  • Unfounded Reports on Thyroid Cancer
    Jae Hoon Chung
    Journal of Korean Medical Science.2014; 29(8): 1033.     CrossRef
  • Regional Lymph Node Metastasis in Papillary Thyroid Cancer
    Jae Hyun Park, Kang San Lee, Keum-Seok Bae, Seong Joon Kang
    Journal of Korean Thyroid Association.2014; 7(2): 129.     CrossRef
  • Methods and Clinical Efficacy of Dosimetry-Based Treatment in Radioiodine Therapy of Thyroid Cancer
    Jin Chul Paeng, June-Key Chung
    Journal of Korean Thyroid Association.2013; 6(1): 43.     CrossRef
  • Two Cases of Non-Small Cell Lung Cancer Masquerading as Metastatic Papillary Thyroid Cancer
    Ju Hee Lee, Se-Hoon Lee, Hye Sook Min, Ji-hoon Kim, Do Joon Park, Young Joo Park
    Journal of Korean Thyroid Association.2012; 5(2): 157.     CrossRef
  • Diagnostic Dilemma of a Follicular Lesions/Neoplasm in Thyroid Fine Needle Aspiration Cytology
    Chan Kwon Jung
    Journal of Korean Thyroid Association.2012; 5(2): 104.     CrossRef
  • Updated guidelines for the diagnosis and management of thyroid nodules
    Ka Hee Yi
    Journal of the Korean Medical Association.2011; 54(6): 629.     CrossRef
Close layer
Editorial
Postoperative Findings of the Cytological Diagnosis of Follicular Neoplasm or Hurthle Cell Neoplasm and Risk of Malignancy.
Jung Uee Lee, Minho Shong
Endocrinol Metab. 2010;25(4):298-300.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.298
  • 1,888 View
  • 23 Download
AbstractAbstract PDF
No abstract available.
Close layer
Note
Management of Obesity, 2010 Recommendation.
Endocrinol Metab. 2010;25(4):301-304.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.301
  • 2,364 View
  • 28 Download
  • 50 Crossref
AbstractAbstract PDF
No abstract available.

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  • Understanding health‐related quality of life trajectories among older adults with diabetes mellitus: Mixed methods research
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    Journal of Nursing Research.2022; 30(2): e199.     CrossRef
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    Seok-Beom Kang, Woo-Seok Shon, Young-Jun Kim, Chang-Hoon Woo
    Journal of Korean Medicine Rehabilitation.2022; 32(2): 19.     CrossRef
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    Journal of Korean Medicine Rehabilitation.2022; 32(4): 1.     CrossRef
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    Taiwanese Journal of Obstetrics and Gynecology.2021; 60(3): 503.     CrossRef
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    Nutrients.2020; 12(2): 429.     CrossRef
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    L. F. Kuznetsova, О. F. Gopko
    Ukraïnsʹkij žurnal medicini, bìologìï ta sportu.2019; 4(4): 14.     CrossRef
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    Toxicology and Environmental Health Sciences.2019; 11(4): 295.     CrossRef
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    BMJ Open.2016; 6(6): e010183.     CrossRef
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    Public Health Nursing.2015; 32(3): 191.     CrossRef
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    Korean Journal of Health Education and Promotion.2015; 32(4): 37.     CrossRef
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    Journal of the Korea Academia-Industrial cooperation Society.2015; 16(10): 7043.     CrossRef
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    Healthcare Informatics Research.2015; 21(1): 10.     CrossRef
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    Asian Nursing Research.2015; 9(3): 251.     CrossRef
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    Respiratory Medicine.2015; 109(1): 96.     CrossRef
  • Health behaviors of Korean female nursing students in relation to obesity and osteoporosis
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    Nursing Outlook.2015; 63(4): 504.     CrossRef
  • The effect of the self-measurement frequency levels on SmartCare obesity management
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    Journal of the Korea Academia-Industrial cooperation Society.2015; 16(3): 1972.     CrossRef
  • The Effect of Nutrition and Exercise or Exercise Program alone on Macronutrients, Sodium Intake and Physical Strength in Middle Aged Obese Women
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Original Articles
The Effects of Combined Treatment of Alendronate Plus Active or Plain Vitamin D on the Vitamin D Metabolism and Bone Turnover Markers in Patients with Osteoporosis.
Jee Hoon Koo, Hyun Kyung Kim, In Sung Kim, Eun Kyung Kim, Yoon Sok Chung
Endocrinol Metab. 2010;25(4):305-309.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.305
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AbstractAbstract PDF
BACKGROUND
The purpose of this study was to evaluate the effects of combined treatment with alendronate plus active or plain vitamin D on the vitamin D metabolism and bone turnover markers in patients with osteoporosis. METHODS: We investigated 297 osteoporosis outpatients who were treated with Maxmarvil(R) (alendronate 5 mg plus calcitriol 0.5 microg) daily or Fosamax Plus(R) (alendronate 70 mg plus cholecalciferol 2,800 IU) weekly for 1 year. The serum levels of 25(OH)D, parathyroid hormone (PTH), calcium, phosphorus, osteocalcin and N-telopeptide were measured at baseline and after 3, 6, and 12 months of treatment. RESULTS: The data of 72 of the 297 patients were analyzed. In the Maxmarvil(R) group (n = 45), the serum PTH significantly decreased by 17% from baseline at 6 months (microd = -6.10; +/- 0.85 SE; P < 0.05) and it remained suppressed to 12 months. The serum 25(OH)D tended to increase, but without significance. In the Fosamax Plus(R) group (n = 27), the serum 25(OH)D significantly increased by 77% from baseline at 3 months (microd = 9.87; +/- 2.32 SE; P < 0.05) and it remained significantly higher than baseline at 6 months (microd = 3.49; +/- 0.86 SE; P < 0.05) and 12 months (microd = 10.47; +/- 0.71 SE; P < 0.001). However, the serum PTH showed no significant decrease. In the Maxmarvil(R) group, the serum osteocalcin significantly decreased by 26% from baseline at 12 months (microd = -5.15; +/- 0.35 SE; P < 0.05), and in the Fosamax Plus(R) group, the serum osteocalcin significantly decreased by 19% from baseline at 6months (microd = -2.64; +/- 0.73 SE; P < 0.05) and it remained suppressed to 12 months (microd = -2.99; +/- 0.37 SE; P = 0.32) without significance. CONCLUSION: Maxmarvil(R) and Fosamax Plus(R) both improved the bone metabolism in Korean osteoporosis patients. Maxmarvil(R) significantly lowered the serum PTH levels, whereas Fosamax Plus(R) significantly elevated the serum 25(OH)D levels.

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  • Efficacy and Safety of Weekly Alendronate Plus Vitamin D35600 IU versus Weekly Alendronate Alone in Korean Osteoporotic Women: 16-Week Randomized Trial
    Kwang Joon Kim, Yong-Ki Min, Jung-Min Koh, Yoon-Sok Chung, Kyoung Min Kim, Dong-Won Byun, In Joo Kim, Mikyung Kim, Sung-Soo Kim, Kyung Wan Min, Ki Ok Han, Hyoung Moo Park, Chan Soo Shin, Sung Hee Choi, Jong Suk Park, Dong Jin Chung, Ji Oh Mok, Hong Sun Ba
    Yonsei Medical Journal.2014; 55(3): 715.     CrossRef
Close layer
Correlation between Pituitary Insufficiency and Magnetic Resonance Imaging Finding in Non-Functioning Pituitary Adenomas.
Hyun Min Kim, Cheol Ryong Ku, Eun Young Lee, Woo Kyung Lee, Jung Soo Lim, Sena Hwang, Mi Jung Lee, Seung Ku Lee, Sun Ho Kim, Eun Jig Lee
Endocrinol Metab. 2010;25(4):310-315.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.310
  • 2,344 View
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  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
Non-functioning pituitary adenomas (NFPAs) are characterized by the absence of clinical and biochemical evidence of pituitary hormone hypersecretion, and these tumors constitute approximately one third of all the tumors of the anterior pituitary. Recently, hormonal deficiencies have gradually evolved to become the leading presenting signs and symptoms in patients with NFPAs. We investigated pituitary hormonal insufficiencies according to the magnetic resonance imaging (MRI) findings in patients with NFPA. METHODS: We evaluated the patients who were newly diagnosed with NFPA from 1997 through 2009. Among them, we analyzed 387 patients who were tested for their combined pituitary function and who underwent MRI. The severity of the hypopituitarism was determined by the number of deficient axes of the pituitary hormones. On the MRI study, the maximal diameter of the tumor, Hardy's classification, the thickness of the pituitary gland and the presence of stalk compression were evaluated. RESULTS: The mean age was 46.85 +/- 12.93 years (range: 15-86) and 186 patients (48.1%) were male. As assessed on MRI, the tumor diameter was 27.87 +/- 9.93 mm, the thickness of the normal pituitary gland was 1.42 +/- 2.07 mm and stalk compression was observed in 201 patients (51.9%). Hypopituitarism was observed in 333 patients (86.0%). Deficiency for each pituitary hormone was most severe in the patients with Hardy type IIIA. Hypopituitarism was severe in the older age patients (P = 0.001) and the patients with a bigger tumor size (P < 0.001) and the presence of stalk compression (P < 0.001). However, the patients who had a thicker pituitary gland showed less severe hypopituitarism (P < 0.001). Multivariate analysis showed that age, tumor diameter and the thickness of pituitary gland were important determinants for pituitary deficiency (P = 0.004, P < 0.001, P = 0.022, respectively). CONCLUSION: The results suggest that the hormonal deficiencies in patient with NFPA were correlated with the MRI findings, and especially the tumor diameter and preservation of the pituitary gland.

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  • Clinical Parameters to Distinguish Silent Corticotroph Adenomas from Other Nonfunctioning Pituitary Adenomas
    Daham Kim, Cheol Ryong Ku, Se Hee Park, Ju Hyung Moon, Eui Hyun Kim, Sun Ho Kim, Eun Jig Lee
    World Neurosurgery.2018; 115: e464.     CrossRef
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Postoperative Findings of the Cytological Diagnosis of Follicular Neoplasm or Hurthle Cell Neoplasm and the Risk of Malignancy.
Ji Hye Yim, Eui Young Kim, Won Gu Kim, Tae Yong Kim, Gyungyup Gong, Suck Joon Hong, Won Bae Kim, Young Kee Shong
Endocrinol Metab. 2010;25(4):316-320.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.316
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AbstractAbstract PDF
BACKGROUND
Follicular neoplasm (FN) or Hurthle cell neoplasm (HN) is a less well understood pitfall when evaluating thyroid nodule with fine-needle aspiration (FNA). This study aimed to determine the rates of malignancy and the predictive factors for malignancy in thyroid nodules with a cytological diagnosis of FN or HN. METHODS: The patients who were cytologically diagnosed as having FN or HN after FNA between 1995 and 2004 at Asan Medical Center were included in this study. We collected the pathology data until 2009 and we analyzed the clinical characteristics associated with malignancy. RESULTS: A total 478 patients were cytologically diagnosed as having FN or HN during the study period and 327 (68%) among them underwent thyroid surgery. Thyroid malignancy was confirmed in 157 (48%) of 327 patients. Malignancy was confirmed in 124 patients with FN (124/253, 49%). They were 48 papillary, 65 follicular, 7 Hurthle cell and 3 medullary carcinomas and 1 anaplastic carcinoma. The malignancy in the cases of HN (33/71, 44.6%) was 9 papillary, 4 follicular and 20 Hurthle cell carcinomas. The risk of malignancy was not associated with male gender, a larger tumor size (> 4 cm) or the diagnosis of HN. However, an age below 20 years (RR 3.6, P = 0.03) and above 60 years (RR 2.3, P = 0.04) was associated with an increased risk of malignancy. CONCLUSION: About half of the patients with FN or HN on FNA cytology were diagnosed as having thyroid cancer after surgery. The malignancy rate for the cytologic diagnosis of HN was similar to that for FN. Thyroid surgery should be recommended for this situation, and especially for patients younger than 20 years or older than 60 years.

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  • Diagnostic Value of Preoperative Serum Thyroglobulin Measurement for the Diagnosis of Malignancy in Follicular or Hürthle Cell Neoplasms of the Thyroid Gland
    Nam Kyu Kim, Seong Joo Kang, Weon Hyoung Lee, Go Eun Yeo, You Jin Han, Bu Kyung Kim, Su Kyoung Kwon, Yo-Han Park, Young Sik Choi
    Kosin Medical Journal.2014; 29(1): 17.     CrossRef
  • Fine Needle Aspiration Cytology of Thyroid Follicular Neoplasm: Cytohistologic Correlation and Accuracy
    Changyoung Yoo, Hyun Joo Choi, Soyoung Im, Ji Han Jung, Kiouk Min, Chang Suk Kang, Young-Jin Suh
    Korean Journal of Pathology.2013; 47(1): 61.     CrossRef
  • Predictive Factors of Malignancy in Thyroid Nodules with a Cytological Diagnosis of Follicular Neoplasm
    Seong Hyeon Lee, Jeong Su Baek, Joo Young Lee, Jung Ah Lim, Soo Youn Cho, Tae Hyun Lee, Yun Hyi Ku, Hong Il Kim, Min Joo Kim
    Endocrine Pathology.2013; 24(4): 177.     CrossRef
  • Postoperative Findings of the Cytological Diagnosis of Follicular Neoplasm or Hürthle Cell Neoplasm and Risk of Malignancy
    Jung Uee Lee, Minho Shong
    Endocrinology and Metabolism.2010; 25(4): 298.     CrossRef
Close layer
Clinical Characteristics of 16 Patients with Pituitary Tumor Incidentally Detected by 18F-Fluorodeoxyglucose PET-CT (18F-FDG PET-CT).
Hyung Jin Kim, Gi Jeong Cheon, A Ra Cho, Chang Hoon Lee, Sang Min Youn, Se jin Ahn, Sang Eon Jang, Jung Min Kim, Yun Yong Lee, Ka Hee Yi
Endocrinol Metab. 2010;25(4):321-325.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.321
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AbstractAbstract PDF
BACKGROUND
It is uncommon to unexpectedly discover pituitary tumor as a hypermetabolic lesion on an 18F-FDG PET-CT scan for the evaluation of an unrelated disease when the patient does not show neurological or endocrine signs and symptoms. METHODS: We retrospectively analyzed the medical records of 16 patients with pituitary tumor that was detected incidentally on 18FFDG PET-CT at the Korea Cancer Center Hospital from January 2002 to September 2009. We analyzed their clinical features in detail. RESULTS: On 35,505 18F-FDG PET-CT scans, 16 (0.045%) patients were diagnosed with pituitary incidentaloma. They underwent 18FFDG PET-CT for the evaluation of the state of malignancy. All of them had no signs and symptoms related to pituitary tumor. The average age of the patients was 63.3 +/- 12.0 years (49-85 years). Eleven patients were men and 5 were women. The mean diameter of the tumor was 17.9 +/- 5.7 mm. Most of the pituitary incidentalomas were macroadenoma. The result of tumor morphologic evaluation by the Hardy classification was as follows: 6 grade IV, 1 grade III, 3 grade II and 1 grade I. The mean standardized uptake value of the tumor was 10.6 +/- 6.7. Ten patients had endocrine evaluation and they showed a normal hormone level. Among 16 patients, 4 patients received TSA and they were diagnosed with pituitary adenoma. CONCLUSION: This study showed that pituitary incidentaloma discovered on 18F-FDG PET-CT was extremely rare. It was almost all non-functioning macroadenoma and this showed relatively high FDG uptake.
Close layer
Medical Service Utilization with Osteoporosis.
Sunmee Jang, Chanmi Park, Suhyun Jang, Hyun Koo Yoon, Chan Soo Shin, Deog Yoon Kim, Yong Chan Ha, Seong Su Lee, Hyung Jin Choi, Young Kyun Lee, Bom Taeck Kim, Ji Yeob Choi
Endocrinol Metab. 2010;25(4):326-339.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.326
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AbstractAbstract PDF
BACKGROUND
Although osteoporosis is increasing in the elderly population, attempts to analyze the patterns of medical service utilization for osteoporosis are currently not sufficient. The medical services and treatment patterns were investigated using Korea's National Health Insurance claims data, which includes all of the Korean population. METHODS: Through the patient identification algorithm developed by using the administrative claims data in 2007, the adult patients (between 50-100 years) with osteoporosis were identified. The age and gender of the patients who used medical service for osteoporosis were described, in relation with six dichotomous variables. The medical service use patterns such as the type of medical institution and conducting bone mineral density measurement were investigated. RESULTS: The number of patients who used medical service were 1,230,580 (females 89.9%). Sixty one point six percent of the patients were prescribed osteoporosis medicine (indicated for osteoporosis only), and 12.9% of the patients had experienced osteoporotic fracture. The primary medical institutions for treatment were clinics (54.3%), while hospitals were mainly used among the patients with a history of fracture and disease or drug use that may induce secondary osteoporosis. The number of visited medical institutions was 6.4 (as an outpatient) and 0.2 (as admissions) during 6 months. The proportion of patients who conducted bone mineral density measurements within one year before and after the diagnosis of osteoporosis was 66.7% and DXA was the most frequently used densitometry (46.3%). The average number of days for the prescriptions for osteoporosis medicine was 70 days. CONCLUSION: In order to prevent further osteoporotic fractures, appropriate management and treatment should be implemented for osteoporosis patients. To do this, we need to understand the current state of medical service utilization and the treatment of osteoporosis using the National Health Insurance claims data.

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    Yong Jun Choi, Han Jin Oh, Dae Jung Kim, Yunhwan Lee, Yoon-Sok Chung
    Journal of Bone and Mineral Research.2012; 27(9): 1879.     CrossRef
  • Dietary factors affecting bone mineral density in Korean rural postmenopausal women
    Jeong Sook Choe, Eun Mi Ahn, Sung Ok Kwon, Young Hee Park, Jinyoung Lee
    Korean Journal of Nutrition.2012; 45(5): 470.     CrossRef
  • Epidemiology and Economic Burden of Osteoporosis in South Korea
    Yong-Chan Ha
    Journal of the Korean Fracture Society.2011; 24(1): 114.     CrossRef
  • Factors associated with the hypertension outpatients' choice of healthcare providers in Korea
    Jung Chan Lee, Kye Hyun Kim, Han Nah Kim, Yoon Hyung Park
    Journal of the Korean Medical Association.2011; 54(9): 961.     CrossRef
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The Clinical Importance of Minimal Extrathyroid Extension on Tumor Recurrence in Patients with Papillary Thyroid Carcinoma.
Jung Min Kim, Yun Yong Lee, Chang Woon Choi, Sang Moo Lim, Seung Sook Lee, Soo Youn Cho, Guk Haeng Lee, Byeong Cheol Lee, Ka Hee Yi
Endocrinol Metab. 2010;25(4):340-346.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.340
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AbstractAbstract PDF
BACKGROUND
We wanted to evaluate whether a minimal extrathyroid extension (METE) is associated with the clinicopathological parameters that are indicative of a poor prognosis, including lymph node metastasis, distant metastasis at the time of the initial diagnosis and tumor recurrence, in patients with papillary thyroid carcinoma (PTC), and especially in the patients with papillary thyroid microcarcinoma (PTMC). METHODS: We retrospectively evaluated the medical records of patients with PTC and who had undergone total thyroidectomy with/without subsequent 131I remnant ablation at the Korea Cancer Center Hospital from January 1998 through December 2005. A total of 557 patients with PTC were enrolled in the study. We excluded 13 patients with an unknown status of extension and 29 patients with massive ETE. RESULTS: Of the 515 patients, 401 were found to have a METE. We analyzed the 464 patients who were without distant metastasis at the time of the initial diagnosis and who had a follow-up duration of more than 6 months. METE was not significantly associated with tumor recurrence during the follow-up period (median follow-up period: 122 months, range: 6-142 months): 8% vs. 15% of the patients with and without METE had tumor recurrence, respectively (P = 0.069 by the log-rank test). We analyzed the effect of tumor size in the patients with METE. Size was not significantly associated with tumor recurrence (P = 0.374 by the log-rank test). CONCLUSION: These findings suggest that METE might not be a prognostic factor to predict tumor recurrence in patients with PTC, including PTMC.

Citations

Citations to this article as recorded by  
  • Sonographic Assessment of the Extent of Extrathyroidal Extension in Thyroid Cancer
    Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee
    Korean Journal of Radiology.2020; 21(10): 1187.     CrossRef
  • Papillary thyroid microcarcinoma: the significance of high risk features
    Nori L. Bradley, Sam M. Wiseman
    BMC Cancer.2017;[Epub]     CrossRef
  • Clinical and Pathologic Predictors of Lymph Node Metastasis and Recurrence in Papillary Thyroid Microcarcinoma
    Saaduddin Siddiqui, Michael G. White, Tatjana Antic, Raymon H. Grogan, Peter Angelos, Edwin L. Kaplan, Nicole A. Cipriani
    Thyroid.2016; 26(6): 807.     CrossRef
  • High metabolic tumor volume and total lesion glycolysis are associated with lateral lymph node metastasis in patients with incidentally detected thyroid carcinoma
    Bo Hyun Kim, Seong-Jang Kim, Keunyoung Kim, Heeyoung Kim, So Jung Kim, Won Jin Kim, Yun Kyung Jeon, Sang Soo Kim, Yong Ki Kim, In Joo Kim
    Annals of Nuclear Medicine.2015; 29(8): 721.     CrossRef
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Case Reports
A Case of Giant Cell Granulomatous Hypophysitis with Recurrent Hypoosmolar Hyponatremia.
Yun Hyeong Lee, Yong Bum Kim, Ju Hee Lee, Kyoung Hye Jeong, Min Kyeong Kim, Kyu Sang Song, Young Suk Jo
Endocrinol Metab. 2010;25(4):347-353.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.347
  • 2,423 View
  • 24 Download
  • 2 Crossref
AbstractAbstract PDF
A 39-year-old woman presented with a 20 day history of recurrent hypoosmolar hyponatremia. Because her volume status seemed to be normal, the most suspected causes of her hyponatremia were adrenal insufficiency and hypothyroidism. Endocrinologic examination, including a combined pituitary function test, showed TSH and ACTH deficiency without GH deficiency, and hyperprolactinemia was also present. Sella MRI showed a pituitary mass, stalk thickening and loss of the normal neurohypophysial hyperintense signal on the T1 weighted image. Pathologic exam demonstrated granulomatous lesions and Langhans' multinucleated giant cells with inflammatory cell infiltration. After high dose methylprednisolone pulse therapy (1 g/day for 3 days) with subsequent prednisolone and levothyoxine replacement, there was no more recurrence of the hyponatremia. The sella MRI on the 6th month showed decreased mass size, narrowed stalk thickening and the reappearance of the normal neurohyphophysial hyperintense signal. She is currently in a good general condition and is receiving hormone replacement therapy.

Citations

Citations to this article as recorded by  
  • Primary Granulomatous Hypophysitis Presenting with Panhypopituitarism and Central Diabetes Insipidus
    Hyun Jin Oh, Ji Young Mok, Ji Eun Kim, Sung Bae Cho, Sang Ah Chang, Ji Hyun Kim, Jung Min Lee
    Korean Journal of Medicine.2015; 88(5): 581.     CrossRef
  • Idiopathic granulomatous hypophysitis: a systematic review of 82 cases in the literature
    Benjamin H. M. Hunn, William G. Martin, Steven Simpson, Catriona A. Mclean
    Pituitary.2014; 17(4): 357.     CrossRef
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A Case of Concurrent Papillary Thyroid Carcinoma in Familial Medullary Thyroid Microcarcinoma with a Germline C634W Mutation.
Ji Hye Kim, Ji Hyun Park, Tae Sun Park, Hong Sun Baek, Myoung Ja Chung, Ki Hwan Hong
Endocrinol Metab. 2010;25(4):354-359.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.354
  • 1,923 View
  • 34 Download
AbstractAbstract PDF
The origins of medullary carcinoma (MTC) and papillary carcinoma (PTC) of the thyroid are embryologically different. Tumors showing concurrent medullary and papillary features are rare and they represent less than 1% of all thyroid malignancies. Hereditary MTC is an autosomal dominantly inherited disease which is genetically determined as part of the MEN 2A, MEN 2B, or variants of MEN 2A such as familial MTC. Germline mutations of the RET gene are the underlying cause of the majority of cases of hereditary medullary carcinomas. The pathogenesis of concurrent PTC with familial MTC has rarely been known. Genetic analysis of the RET oncogene has so far provided conflicting results. Here we describe a family whose sibling was affected by both PTC & MTC, and the family carried a germ-line point mutation in the RET extracellular domain that converted cysteine 634 into tryptophan (C634W).
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A Case of Thyroid Amyloidosis Misrecognized as Subacute Thyroiditis.
Young Sil Lee, Seong Su Moon, Soon Kim, Jong Im Lee
Endocrinol Metab. 2010;25(4):360-364.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.360
  • 1,847 View
  • 29 Download
  • 1 Crossref
AbstractAbstract PDF
Amyloid deposition in the thyroid is found in about 30-80% of the patients with primary or secondary amyloidosis. In a few patients with amyloidosis, the thyroid is enlarged and so called amyloid goiter occurs. The thyroid function usually remains normal, but occasionally hypothyroidism or thyrotoxicosis occurs in patients with thyroid amyloidosis. We have experienced one case of thyroid amyloidosis due to bronchiectasis and the patient developed painful goiter and transient thyrotoxicosis resembling subacute thyroiditis. Biopsies from the gastric antrum, duodenum, colon, kidney and thyroid were positive for deposition of amyloid. When patients have signs and symptoms of subacute thyroiditis, but they develop an unusual course, then the diagnosis of thyroid amyloidosis should be considered.

Citations

Citations to this article as recorded by  
  • Amyloid goiter mimicking subacute thyroiditis on clinical and imaging findings: A case report
    Yoo Jin Lee, Soo Jin Jung, Dong Wook Kim, Hwa Jin Cho, Ki Jung Ahn
    Journal of Clinical Ultrasound.2018; 46(7): 497.     CrossRef
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