Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Article category

Page Path
HOME > Article category > Article category
781 Article category
Filter
Filter
Article type
Article category
Keywords
Publication year
Authors
Funded articles
Review Articles
Thyroid
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach
Chan Kwon Jung, Andrey Bychkov, Kennichi Kakudo
Endocrinol Metab. 2022;37(5):703-718.   Published online October 4, 2022
DOI: https://doi.org/10.3803/EnM.2022.1553
  • 14,920 View
  • 2,004 Download
  • 45 Web of Science
  • 56 Crossref
AbstractAbstract PDFPubReader   ePub   
The fifth edition of the World Health Organization (WHO) histologic classification of thyroid neoplasms released in 2022 includes newly recognized tumor types, subtypes, and a grading system. Follicular cell-derived neoplasms are categorized into three families (classes): benign tumors, low-risk neoplasms, and malignant neoplasms. The terms “follicular nodular disease” and “differentiated high-grade thyroid carcinoma” are introduced to account for multifocal hyperplastic/neoplastic lesions and differentiated thyroid carcinomas with high-grade features, respectively. The term “Hürthle cells” is replaced with “oncocytic cells.” Invasive encapsulated follicular and cribriform morular variants of papillary thyroid carcinoma (PTC) are now redefined as distinct tumor types, given their different genetic alterations and clinicopathologic characteristics from other PTC subtypes. The term “variant” to describe a subclass of tumor has been replaced with the term “subtype.” Instead, the term “variant” is reserved to describe genetic alterations. A histologic grading system based on the mitotic count, necrosis, and/or the Ki67 index is used to identify high-grade follicular-cell derived carcinomas and medullary thyroid carcinomas. The 2022 WHO classification introduces the following new categories: “salivary gland-type carcinomas of the thyroid” and “thyroid tumors of uncertain histogenesis.” This review summarizes the major changes in the 2022 WHO classification and their clinical relevance.

Citations

Citations to this article as recorded by  
  • Tumeurs de la thyroïde : nouveautés de la classification OMS 2022
    Serge Guyétant, Myriam Decaussin Petrucci, Emmanuelle Leteurtre
    Annales de Pathologie.2024; 44(1): 5.     CrossRef
  • Diagnostic Performance of [18F]TFB PET/CT Compared with Therapeutic Activity [131I]Iodine SPECT/CT and [18F]FDG PET/CT in Recurrent Differentiated Thyroid Carcinoma
    David Ventura, Matthias Dittmann, Florian Büther, Michael Schäfers, Kambiz Rahbar, Daniel Hescheler, Michael Claesener, Philipp Schindler, Burkhard Riemann, Robert Seifert, Wolfgang Roll
    Journal of Nuclear Medicine.2024; 65(2): 192.     CrossRef
  • Clinicopathological features of differentiated thyroid carcinoma as predictors of the effects of radioactive iodine therapy
    Wen Liu, Beibei Jiang, Jingli Xue, Ruijing Liu, Yuqing Wei, Peifeng Li
    Annals of Diagnostic Pathology.2024; 69: 152243.     CrossRef
  • Management of aggressive variants of papillary thyroid cancer
    Ying Ki Lee, Aleix Rovira, Paul V. Carroll, Ricard Simo
    Current Opinion in Otolaryngology & Head & Neck Surgery.2024; 32(2): 125.     CrossRef
  • Artificial Intelligence Detected the Relationship Between Nuclear Morphological Features and Molecular Abnormalities of Papillary Thyroid Carcinoma
    Toui Nishikawa, Ibu Matsuzaki, Ayata Takahashi, Iwamoto Ryuta, Fidele Yambayamba Musangile, Kanako Sagan, Mizuki Nishikawa, Yurina Mikasa, Yuichi Takahashi, Fumiyoshi Kojima, Shin-ichi Murata
    Endocrine Pathology.2024;[Epub]     CrossRef
  • Review of the 2023 World Congress on Thyroid Cancer (WCTC 2023, London): is there light at the end of the tunnel for patients with neglected cancer?
    S.M. Cherenko
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2024; 19(8): 609.     CrossRef
  • Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma
    Lindsay A. Bischoff, Ian Ganly, Laura Fugazzola, Erin Buczek, William C. Faquin, Bryan R. Haugen, Bryan McIver, Caitlin P. McMullen, Kate Newbold, Daniel J. Rocke, Marika D. Russell, Mabel Ryder, Peter M. Sadow, Eric Sherman, Maisie Shindo, David C. Shonk
    JAMA Otolaryngology–Head & Neck Surgery.2024;[Epub]     CrossRef
  • Malignancy in a Solitary Thyroid Nodule: A Retrospective Histopathological Evaluation
    Hassan Alzahrani
    International Journal of General Medicine.2024; Volume 17: 135.     CrossRef
  • Thyroïde : actualités et problèmes pratiques. Introduction
    Serge Guyétant
    Annales de Pathologie.2024;[Epub]     CrossRef
  • Diagnostic implication of thyroid spherules for cytological diagnosis of thyroid nodules
    Heeseung Sohn, Kennichi Kakudo, Chan Kwon Jung
    Cytopathology.2024;[Epub]     CrossRef
  • Aggressive Primary Thyroid Mucoepidermoid Carcinoma with Extensive Pulmonary Involvement
    Marius Mitrache, Dana Terzea, Anca Sirbu, Simona Fica
    Biomedicines.2024; 12(2): 285.     CrossRef
  • Unravelling the role of long non-coding RNAs in modulating the Hedgehog pathway in cancer
    Shailendra Singh Chandel, Anurag Mishra, Gaurav Dubey, Ravindra Pal Singh, Mithilesh Singh, Mohit Agarwal, Himmat Singh Chawra, Neelima Kukreti
    Pathology - Research and Practice.2024; 254: 155156.     CrossRef
  • Hürthle cell (Oncocytic) carcinoma – Is hemithyroidectomy enough?
    Taylor O. Julsrud, Trenton R. Foster, Robert A. Vierkant, Melanie L. Lyden, Travis J. McKenzie, Mabel Ryder, Benzon M. Dy
    Surgical Oncology Insight.2024; 1(1): 100010.     CrossRef
  • Échographie des carcinomes thyroïdiens différenciés de souche folliculaire
    P.Y. Marcy, M. Tassart, J.G. Marchand, J. Sanglier, A. Bizeau, E. Ghanassia
    Journal d'imagerie diagnostique et interventionnelle.2024;[Epub]     CrossRef
  • Differentiating BRAF V600E- and RAS-like alterations in encapsulated follicular patterned tumors through histologic features: a validation study
    Chankyung Kim, Shipra Agarwal, Andrey Bychkov, Jen-Fan Hang, Agnes Stephanie Harahap, Mitsuyoshi Hirokawa, Kennichi Kakudo, Somboon Keelawat, Chih-Yi Liu, Zhiyan Liu, Truong Phan-Xuan Nguyen, Chanchal Rana, Huy Gia Vuong, Yun Zhu, Chan Kwon Jung
    Virchows Archiv.2024;[Epub]     CrossRef
  • Histoséminaire SFP Thyroïde : actualités et problèmes pratiques. Cas no 5
    Myriam Decaussin-Petrucci
    Annales de Pathologie.2024;[Epub]     CrossRef
  • Current and future of immunotherapy for thyroid cancer based on bibliometrics and clinical trials
    Ke Wang, Ying Zhang, Yang Xing, Hong Wang, Minghua He, Rui Guo
    Discover Oncology.2024;[Epub]     CrossRef
  • Histoséminaire / Thyroïde : actualités et problèmes pratiques. Cas no 6
    Myriam Decaussin-Petrucci
    Annales de Pathologie.2024;[Epub]     CrossRef
  • Papillary Thyroid Carcinoma With Lymphoepithelial Features and Lacking Association With Epstein-Barr Virus (EBV): A Rare Case
    Ahmed Bendari, Saroja Devi Geetha, Reham Al-Refai, Xuelin Zhong, Sunder Sham, Manju Harshan
    Cureus.2024;[Epub]     CrossRef
  • Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma
    Chan Kwon Jung, Shipra Agarwal, Jen-Fan Hang, Dong-Jun Lim, Andrey Bychkov, Ozgur Mete
    Endocrine Pathology.2023; 34(1): 1.     CrossRef
  • The 5th edition of WHO classification of tumors of endocrine organs: changes in the diagnosis of follicular-derived thyroid carcinoma
    Fulvio Basolo, Elisabetta Macerola, Anello Marcello Poma, Liborio Torregrossa
    Endocrine.2023; 80(3): 470.     CrossRef
  • Preoperative Risk Stratification of Follicular-patterned Thyroid Lesions on Core Needle Biopsy by Histologic Subtyping and RAS Variant-specific Immunohistochemistry
    Meejeong Kim, Sora Jeon, Chan Kwon Jung
    Endocrine Pathology.2023; 34(2): 247.     CrossRef
  • Ultrasound evolution of parenchymal changes in the thyroid gland with autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma – a follow-up study
    Dominika Januś, Monika Kujdowicz, Małgorzata Wójcik, Anna Taczanowska-Niemczuk, Aleksandra Kiszka-Wiłkojć, Wojciech Górecki, Jerzy B. Starzyk
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Papillary thyroid carcinoma with aggressive fused follicular and solid growth pattern: A unique histological subtype with high‐grade malignancy?
    Shin‐ichi Murata, Ibu Matsuzaki, Mitsuo Kishimoto, Naomi Katsuki, Toshinori Onishi, Mitsuyoshi Hirokawa, Fumiyoshi Kojima
    Pathology International.2023; 73(5): 207.     CrossRef
  • Multi-Omics and Management of Follicular Carcinoma of the Thyroid
    Thifhelimbilu Emmanuel Luvhengo, Ifongo Bombil, Arian Mokhtari, Maeyane Stephens Moeng, Demetra Demetriou, Claire Sanders, Zodwa Dlamini
    Biomedicines.2023; 11(4): 1217.     CrossRef
  • Molecular Genetics of Diffuse Sclerosing Papillary Thyroid Cancer
    Meshael Alswailem, Balgees Alghamdi, Anwar Alotaibi, Abeer Aljomiah, Hindi Al-Hindi, Avaniyapuram Kannan Murugan, Mohamed Abouelhoda, Yufei Shi, Ali S Alzahrani
    The Journal of Clinical Endocrinology & Metabolism.2023; 108(9): e704.     CrossRef
  • Multifunctional Phase-Transition Nanoparticles for Effective Targeted Sonodynamic-Gene Therapy Against Thyroid Papillary Carcinoma
    Shihui Guan, Dengke Teng, Hui Wang, Qimeihui Wang, Xi Zhen, Guoqing Sui, Yang Wang, Lingyu Zhu, Yuanqiang Lin, Dan Jiao, Feng Guo
    International Journal of Nanomedicine.2023; Volume 18: 2275.     CrossRef
  • Utilizing Dynamic Risk Stratification in Patients With Tall Cell Variant Papillary Thyroid Cancer
    David Zimmer, Gilman Plitt, Brandon Prendes, Jamie Ku, Natalie Silver, Eric Lamarre, Emrullah Yilmaz, Jessica Geiger, Christian Nasr, Lea El Hage, Mario Skugor, Shauna Cambpell, Shlomo Koyfman, Jacob Miller, Neil Woody, Katherine Heiden, Nikhil Joshi, Tar
    The Laryngoscope.2023; 133(9): 2430.     CrossRef
  • Ultrasound, laboratory and histopathological insights in diagnosing papillary thyroid carcinoma in a paediatric population: a single centre follow-up study between 2000-2022
    Dominika Januś, Małgorzata Wójcik, Anna Taczanowska-Niemczuk, Aleksandra Kiszka-Wiłkojć, Monika Kujdowicz, Małgorzata Czogała, Wojciech Górecki, Jerzy B. Starzyk
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Medullary Thyroid Carcinoma: A Single Institute Experience
    Sonal Trivedi, T. Salahuddin, Mohamed Taher Mithi, Priyank Rathod, Arpit Bandi, Shashank J. Pandya, Mohit Sharma, Shailesh Patel, Vikas Warikoo, Ketul Puj, Abhijeet Salunkhe, Keval Patel, Shivam Pandya
    Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(4): 2884.     CrossRef
  • FNAC (Fine needle aspiration cytology) and histopathological correlation and reclassification of thyroid neoplasm in accordance with WHO classification 2022
    Fareeda Joshi, Shreya Hegde
    Indian Journal of Pathology and Oncology.2023; 10(2): 132.     CrossRef
  • Papillary thyroid carcinoma associated with non‑functioning parathyroid carcinoma with Warthin's tumor of the parotid gland: A case report and brief literature review
    Ari Abdullah, Aras Qaradakhy, Yadgar Saeed, Abdulwahid Salih, Seema Karim, Osama Ali, Shko Hassan, Shalaw Nasraldeen, Shvan Mohammed, Fahmi Kakamad
    Medicine International.2023;[Epub]     CrossRef
  • Warthin-like papillary thyroid carcinoma: a case report and comprehensive review of the literature
    Abdel Mouhaymen Missaoui, Fatma Hamza, Wafa Belabed, Manel Mellouli, Mohamed Maaloul, Slim Charfi, Issam Jardak, Tahya Sellami-Boudawara, Nabila Rekik, Mohamed Abid
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Reevaluating diagnostic categories and associated malignancy risks in thyroid core needle biopsy
    Chan Kwon Jung
    Journal of Pathology and Translational Medicine.2023; 57(4): 208.     CrossRef
  • Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street
    Ioana Balinisteanu, Monica-Cristina Panzaru, Lavinia Caba, Maria-Christina Ungureanu, Andreea Florea, Ana Maria Grigore, Eusebiu Vlad Gorduza
    Biomedicines.2023; 11(8): 2143.     CrossRef
  • Deep learning prediction model for central lymph node metastasis in papillary thyroid microcarcinoma based on cytology
    Wenhao Ren, Yanli Zhu, Qian Wang, Yuntao Song, Zhihui Fan, Yanhua Bai, Dongmei Lin
    Cancer Science.2023; 114(10): 4114.     CrossRef
  • Cytology and Histology of Thyroid Nodules: Exploring Novel Insights in the Molecular Era for Enhanced Patient Management
    Beatrix Cochand-Priollet, Zahra Maleki
    Current Oncology.2023; 30(8): 7753.     CrossRef
  • Agrin is a novel oncogenic protein in thyroid cancer
    Anna Adamiok‑Ostrowska, Małgorzata Grzanka, Barbara Czarnocka
    Oncology Letters.2023;[Epub]     CrossRef
  • Analysis of Pathological Features of Thyroid Carcinoma in the Western Yunnan
    身吾 王
    Advances in Clinical Medicine.2023; 13(10): 15820.     CrossRef
  • Insight of novel biomarkers for papillary thyroid carcinoma through multiomics
    Wei Liu, Junkan Zhu, Zhen Wu, Yongxiang Yin, Qiao Wu, Yiming Wu, Jiaojiao Zheng, Cong Wang, Hongyan Chen, Talal Jamil Qazi, Jun Wu, Yuqing Zhang, Houbao Liu, Jingmin Yang, Daru Lu, Xumin Zhang, Zhilong Ai
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Identification of NIFTP-Specific mRNA Markers for Reliable Molecular Diagnosis of Thyroid Tumors
    So-Yeon Lee, Jong-Lyul Park, Kwangsoon Kim, Ja Seong Bae, Jae-Yoon Kim, Seon-Young Kim, Chan Kwon Jung
    Endocrine Pathology.2023; 34(3): 311.     CrossRef
  • Somatostatin Receptor Type 2 and Thyroid-Stimulating Hormone Receptor Expression in Oncocytic Thyroid Neoplasms: Implications for Prognosis and Treatment
    Andrea Gillis, Rui Zheng-Pywell, Chandler McLeod, Dezhi Wang, John M. Ness, Rachael Guenter, Jason Whitt, Tomas A. Prolla, Herbert Chen, Manuel Lora Gonzalez, Bart Rose, Ricardo V. Lloyd, Renata Jaskula-Sztul, Diana Lin
    Modern Pathology.2023; 36(12): 100332.     CrossRef
  • Comparison of Treatment and Prognosis Between Follicular Variant Papillary Thyroid Carcinoma and Classical Papillary Thyroid Carcinoma
    Bing Zhang, Wenming Wu, Jinjing Liu, Zhou Liang, Liang Zong
    Hormone and Metabolic Research.2023; 55(12): 855.     CrossRef
  • Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma
    Isabella Merante Boschin, Loris Bertazza, Carla Scaroni, Caterina Mian, Maria Rosa Pelizzo
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Utility of the Growth Differentiation Factor-15 in the Differential Diagnosis of Follicular-Patterned Lesions of the Thyroid on Cytopathologic and Histopathologic Samples
    Prasanna V Perumal, Neelaiah Siddaraju, Sunil K Saxena, Soundravally Rajendiran, Ramachandra V Bhat
    Cureus.2023;[Epub]     CrossRef
  • Investigation of pre‐operative demographic, biochemical, sonographic and cytopathological findings in low‐risk thyroid neoplasms
    Muzaffer Serdar Deniz, Didem Özdemir, Narin Nasıroğlu İmga, Hüsniye Başer, Fatma Neslihan Çuhacı Seyrek, Ayşegül Aksoy Altınboğa, Oya Topaloğlu, Reyhan Ersoy, Bekir Çakır
    Clinical Endocrinology.2023; 99(5): 502.     CrossRef
  • Applications of machine and deep learning to thyroid cytology and histopathology: a review
    Greg Slabaugh, Luis Beltran, Hasan Rizvi, Panos Deloukas, Eirini Marouli
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • The Asian Thyroid Working Group, from 2017 to 2023
    Kennichi Kakudo, Chan Kwon Jung, Zhiyan Liu, Mitsuyoshi Hirokawa, Andrey Bychkov, Huy Gia Vuong, Somboon Keelawat, Radhika Srinivasan, Jen-Fan Hang, Chiung-Ru Lai
    Journal of Pathology and Translational Medicine.2023; 57(6): 289.     CrossRef
  • Anaplastic thyroid cancer: Pathogenesis, prognostic factors and genetic landscape (Review)
    Abdul-Mohsen Alhejaily, Omar Alhuzim, Yazeed Alwelaie
    Molecular and Clinical Oncology.2023;[Epub]     CrossRef
  • Simultaneous Occurrence of Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma: A Case Series with Literature Review
    Poupak Fallahi, Armando Patrizio, Giulio Stoppini, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Eugenia Balestri, Valeria Mazzi, Chiara Botrini, Gilda Varricchi, Salvatore Ulisse, Marco Ghionzoli, Alessandro Antonelli, Silvia Martina Ferrari
    Current Oncology.2023; 30(12): 10237.     CrossRef
  • Construction and validation of a nomogram for predicting cervical lymph node metastasis in diffuse sclerosing variant of papillary thyroid carcinoma
    Xunyi Lin, Jiaxing Huo, Huan Zhang, Hang Su, Fenghua Zhang
    Langenbeck's Archives of Surgery.2023;[Epub]     CrossRef
  • Canine follicular cell and medullary thyroid carcinomas: Immunohistochemical characterization
    Jana Jankovic, Eve Tièche, Martina Dettwiler, Kerstin Hahn, Stephanie Scheemaeker, Martin Kessler, Sylvie Daminet, Sven Rottenberg, Miguel Campos
    Veterinary Pathology.2023;[Epub]     CrossRef
  • A 16-Year Single-Center Series of Trachea Resections for Locally Advanced Thyroid Carcinoma
    Julia I. Staubitz-Vernazza, Sina Schwind, Oana Lozan, Thomas J. Musholt
    Cancers.2023; 16(1): 163.     CrossRef
  • Reprogramming of Cellular Metabolism and Its Therapeutic Applications in Thyroid Cancer
    Yuji Nagayama, Koichiro Hamada
    Metabolites.2022; 12(12): 1214.     CrossRef
  • Developments to improve outcomes in thyroid surgery
    Thomas J. Musholt
    Innovative Surgical Sciences.2022; 7(3-4): 77.     CrossRef
  • The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure
    Tetiana Bogdanova, Serhii Chernyshov, Liudmyla Zurnadzhy, Tatiana I. Rogounovitch, Norisato Mitsutake, Mykola Tronko, Masahiro Ito, Michael Bolgov, Sergii Masiuk, Shunichi Yamashita, Vladimir A. Saenko
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
Close layer
Diabetes
Therapeutic Role of Yoga in Type 2 Diabetes
Arkiath Veettil Raveendran, Anjali Deshpandae, Shashank R. Joshi
Endocrinol Metab. 2018;33(3):307-317.   Published online August 14, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.307
  • 11,033 View
  • 276 Download
  • 42 Web of Science
  • 56 Crossref
AbstractAbstract PDFPubReader   ePub   

Yoga originated in India more than 5,000 years ago and is a means of balancing and harmonizing the body, mind, and emotions. Yoga practice is useful in the management of various lifestyle diseases, including type 2 diabetes. Psycho-neuro-endocrine and immune mechanisms are involved in the beneficial effects of yoga on diabetes. Incorporation of yoga practice in daily life helps to attain glycaemic control and reduces the risk of complications in people with diabetes. In this review, we briefly describe the role of various yoga practices in the management of diabetes based on evidence from various clinical studies.

Citations

Citations to this article as recorded by  
  • Clinical Practice Guidelines for mental health and well-being in patients with chronic medical illnesses
    Sandeep Grover, Ajit Avasthi, Abdul Majid
    Indian Journal of Psychiatry.2024; 66(Suppl 2): S338.     CrossRef
  • Complementary and alternative system of medicine for type 2 diabetes mellitus and its complications: A scoping review
    Shradha S Parsekar, Nachiket Gudi, Sujata Chodankar Walke, Prabhu Dutta Shaw, Aditi Hombali, Anupama V Nayak, Basavaraj S Hadapad
    F1000Research.2024; 11: 526.     CrossRef
  • CLINICAL STUDY OF YOGASANA AND PATHYAAHARA IN MANAGEMENT OF MADHUMEHA (DIABETES MELLITUS-2)
    Jyoti Prajapati, Pramod Kumar Mishra, Brahmanand Sharma
    International Ayurvedic Medical Journal.2024; 12(02): 346.     CrossRef
  • Therapeutic role of yoga in hypertension
    Anjali Mangesh Joshi, Arkiath Veettil Raveendran, Muruganathan Arumugam
    World Journal of Methodology.2024;[Epub]     CrossRef
  • A self-management plus mind body intervention for adolescents and young adults with type 2 diabetes: Trial design and methodological report
    Molly McVoy, David Miller, Irina Bransteter, Rose Gubitosi-Klug, Tracy Segal, Jessica Surdam, Martha Sajatovic, Jeffery A. Dusek
    Contemporary Clinical Trials.2023; 133: 107317.     CrossRef
  • Epidemiology of type 2 diabetes mellitus and treatment utilization patterns among the elderly from the first wave of Longitudinal Aging study in India (2017-18)using a Heckman selection model
    Papai Barman, Milan Das, Madhur Verma
    BMC Public Health.2023;[Epub]     CrossRef
  • Is Type 2 Diabetes Mellitus a Behavioural Disorder? An Evidence Review for Type 2 Diabetes Mellitus Prevention and Remission through Lifestyle Modification
    Matthias Li, Mohammad Sadiq Jeeyavudeen, Ganesan Arunagirinathan, Joseph Pappachan
    European Endocrinology.2023; 19(1): 7.     CrossRef
  • Yoga practice can reduce metabolic syndrome and cardiovascular risk in climacteric women
    Laura Alves Cota e Souza, Thiago Magalhães Gouvea, Francielle Caroline Fernandes, Maria Ruth Gonçalves Gaede Carrillo, Vanja Maria Veloso, Ariosvaldo Figueiredo Santos Filho, Angélica Alves Lima
    Journal of Behavioral Medicine.2023;[Epub]     CrossRef
  • Yogic practices for dyslipidemia in type 2 diabetes mellitus: A systematic review of randomized-controlled trials
    Bandana Sairem, Khushbu Jain
    BLDE University Journal of Health Sciences.2023; 8(1): 20.     CrossRef
  • Effect of yoga protocol in primary snoring: A pilot study
    JojanJ Jerone, Ashok Patil, SavitaS Angadi, AmalS Chandran
    Journal of Ayurveda.2023; 17(2): 114.     CrossRef
  • Effects of different mind-body exercises on glucose and lipid metabolism in patients with type 2 diabetes: A network meta-analysis
    Sijun Wu, Lin Wang, Yuxuan He, Fengrui Shi, Huiqi Zhuang, Linqi Mei, Youling Qian
    Complementary Therapies in Clinical Practice.2023; 53: 101802.     CrossRef
  • Mechanisms of improved body composition among perimenopausal women practicing Meditative Movement: a proposed biobehavioral model
    Dara L. James, Linda K. Larkey, Bronwynne Evans, Ann Sebren, Kimberley Goldsmith, Erica Ahlich, Nanako A. Hawley, Afton Kechter, Dorothy D. Sears
    Menopause.2023; 30(11): 1114.     CrossRef
  • A comparative analysis of Vamana and Shamana Chikitsa in prediabetes management: A randomized clinical trial
    Uttamram Yadav, Santosh Kumar Bhatted
    Journal of Ayurveda and Integrative Medicine.2023; 14(5): 100764.     CrossRef
  • Siddha Therapeutic Approach to Diabetic Nephropathy – A Review
    P. Parvathy, G. S. Lekha, S. Aparna, A. Kanagarajan
    Journal of Natural Remedies.2023; : 1359.     CrossRef
  • Enhancing Type 2 Diabetes Management: Exploring the Synergistic Impact of Vestibular Exercise and Yoga
    Athira MS, Sheela Joice P P, Mohan Varughese, Suresh Babu Sayana
    Cureus.2023;[Epub]     CrossRef
  • Dynamic In Silico Model of Type 2 Diabetes Treated With Metformin Combined With Exercise: A Sobol Sensitivity Analysis
    Darshna M. Joshi
    Avicenna Journal of Pharmaceutical Research.2023; 3(2): 91.     CrossRef
  • Complementary and alternative system of medicine for type 2 diabetes mellitus and its complications: A scoping review
    Shradha S Parsekar, Nachiket Gudi, Sujata Chodankar Walke, Prabhu Dutta Shaw, Aditi Hombali, Anupama V Nayak, Basavaraj S Hadapad
    F1000Research.2023; 11: 526.     CrossRef
  • Exploring the Impact of Combined Thai Yoga and Elastic Band Exercise on Physical Fitness and Exercise Capacity in Older Patients with Type 2 Diabetes
    Nattha Muangritdech, Tichanon Promsrisuk, Ratchaniporn Kongsui, Napatr Sriraksa, Sitthisak Thongrong, Arunrat Srithawong
    Physical Education Theory and Methodology.2023; 23(6): 894.     CrossRef
  • Role of Yoga and Its Plausible Mechanism in the Mitigation of DNA Damage in Type-2 Diabetes: A Randomized Clinical Trial
    Rajesh G Nair, Mithila M Vasudev, Ramesh Mavathur
    Annals of Behavioral Medicine.2022; 56(3): 235.     CrossRef
  • Efficacy of Integrated Ayurveda treatment protocol in type 2 Diabetes Mellitus – A case report
    Suketha Kumari, Laxmikant S.D, Sonika B, Suman Khanal
    Journal of Ayurveda and Integrative Medicine.2022; 13(1): 100512.     CrossRef
  • Role of structured exercise therapy on cognitive markers and stress parameters in young patients with Type 2 diabetes mellitus
    Harpreet Kour, VA Kothiwale, ShivaprasadS Goudar
    Indian Journal of Health Sciences and Biomedical Research (KLEU).2022; 15(1): 70.     CrossRef
  • The Influence of Amateur Sports on Health Quality
    M. M. Vovchenko
    Ukraïnsʹkij žurnal medicini, bìologìï ta sportu.2022; 7(1): 8.     CrossRef
  • Complementary and alternative system of medicine for type 2 diabetes mellitus and its complications: A scoping review
    Shradha S Parsekar, Nachiket Gudi, Sujata Chodankar Walke, Prabhu Dutta Shaw, Aditi Hombali, Anupama V Nayak, Basavaraj S Hadapad
    F1000Research.2022; 11: 526.     CrossRef
  • Neuroimaging perspective in targeted treatment for type 2 diabetes melitus and sleep disorders
    Karen M. von Deneen, Malgorzata A. Garstka
    Intelligent Medicine.2022; 2(4): 209.     CrossRef
  • Efficacy of yoga practices on emotion regulation and mindfulness in type 2 diabetes mellitus patients
    Amit Kanthi, Singh Deepeshwar, Chidananda Kaligal, Mahadevappa Vidyashree, Dwivedi Krishna
    Yoga Mimamsa.2022; 54(1): 12.     CrossRef
  • Inside the diabetic brain: Insulin resistance and molecular mechanism associated with cognitive impairment and its possible therapeutic strategies
    Bhaskar Jyoti Dutta, Shamsher Singh, Sanket Seksaria, Ghanshyam Das Gupta, Amrita Singh
    Pharmacological Research.2022; 182: 106358.     CrossRef
  • LINKAGE OF YOGA TO OXIDATIVE STRESS IN PATIENTS WITH DIABETES MELLITUS, TYPE 2
    Deepika Khatri, Yuliya Tyravska
    InterConf.2022; (15(117)): 215.     CrossRef
  • An Observational Study on the Effect of Yoga and Sudarshan Kriya in Type 2 Diabetes Mellitus Patients
    Meenakshi R Verma, Deepakkumar G Langade, Rahul D Rao, Shreya Shivangi, Sonali Khedkar, Divya Kanchibhotla
    Cureus.2022;[Epub]     CrossRef
  • The most effective exercise to prevent obesity: A longitudinal study of 33,731 Taiwan biobank participants
    Wan-Yu Lin
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Type 2 diabetes mellitus, its impact on quality of life and how the disease can be managed-a review
    Priyanka Garg, Navneet Duggal
    Obesity Medicine.2022; 35: 100459.     CrossRef
  • Effect of om chanting and yoga nidra on blood pressure and lipid profile in hypertension – A randomized controlled trial
    K. Anjana, R. Archana, J.K. Mukkadan
    Journal of Ayurveda and Integrative Medicine.2022; 13(4): 100657.     CrossRef
  • Effect of yoga intervention on skeletal muscle linked glucose homeostasis in pre-diabetic individuals: Study protocol for a randomized controlled trial
    Supriya Bhalerao, Jayshree Kharche, Shubhangi Harke
    Advances in Integrative Medicine.2022; 9(4): 230.     CrossRef
  • Popular Complementary and Alternative Therapy Methods in Different Conditions
    Akın SÜZER, Nevriye ÜNAL SÜZER, Raziye ŞAVKIN, Nihal BÜKER
    International Journal of Traditional and Complementary Medicine Research.2022; 3(3): 201.     CrossRef
  • Add on Hypoglycemic effect of customized Yoga module in diabetes mellitus: A case report
    KK Resmi, MB Kavita, Gurubasavaraj Yalagachin
    Journal of Ayurveda Case Reports.2022; 5(4): 163.     CrossRef
  • Modern Postural Yoga and the Health-Spirituality-Neoliberalism Nexus
    Matteo Di Placido, Anna Strhan, Stefania Palmisano
    Fieldwork in Religion.2022;[Epub]     CrossRef
  • Metabolic syndrome and possible treatments (consecutive therapies): a literature review
    Jitender Sorout, Sudhanshu Kacker, Neha Saboo
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2022; 18(6): 351.     CrossRef
  • Umbilical Cord-Mesenchymal Stem Cell-Conditioned Medium Improves Insulin Resistance in C2C12 Cell
    Kyung-Soo Kim, Yeon Kyung Choi, Mi Jin Kim, Jung Wook Hwang, Kyunghoon Min, Sang Youn Jung, Soo-Kyung Kim, Yong-Soo Choi, Yong-Wook Cho
    Diabetes & Metabolism Journal.2021; 45(2): 260.     CrossRef
  • Yoga as a complementary therapy for metabolic syndrome: A narrative review
    Dastan M. Khoshnaw, Abhijit A. Ghadge
    Journal of Integrative Medicine.2021; 19(1): 6.     CrossRef
  • Effect of yoga on glycemia and lipid parameters in type-2 diabetes: a meta-analysis
    Deep Dutta, Saptarshi Bhattacharya, Meha Sharma, Deepak Khandelwal, Vineet Surana, Sanjay Kalra
    Journal of Diabetes & Metabolic Disorders.2021; 20(1): 349.     CrossRef
  • Effect of Yoga on Glucose Control and Quality of Life in Patients of Prediabetes
    Rajesh Rajput, Karamvir Yadav, Meena Rajput, Jyoti Yadav, Neharika Saini
    Metabolic Syndrome and Related Disorders.2021; 19(8): 417.     CrossRef
  • Effect of long-term Yogic practices in type 2 diabetes mellitus: a single case study
    KetakiH Patil, Vidya Wasnik (Thatere), VijayG Patrikar
    Journal of Indian System of Medicine.2021; 9(2): 135.     CrossRef
  • Effectiveness of Yoga Lifestyle on Lipid Metabolism in a Vulnerable Population—A Community Based Multicenter Randomized Controlled Trial
    Raghuram Nagarathna, Saurabh Kumar, Akshay Anand, Ishwara N. Acharya, Amit Kumar Singh, Suchitra S. Patil, Ramesh H Latha, Purnima Datey, Hongasandra Ramarao Nagendra
    Medicines.2021; 8(7): 37.     CrossRef
  • Yoga for Healthy Aging: Science or Hype?

    Advances in Geriatric Medicine and Research.2021;[Epub]     CrossRef
  • A Prospective Study on Type-2 Diabetic Complications and Efficacy of Integrated Yoga: A Pan India 2017
    Suchitra S. Patil, Nagarathna Raghuram, Amit Singh, S. K. Rajesh, Sabzar Ahmed, Nagendra Hongasandra
    Annals of Neurosciences.2021; 28(1-2): 21.     CrossRef
  • Effects of Yoga Therapy and Walking Therapy in Reducing Blood Sugar Levels on Diabetes Mellitus Patients in the Community
    Wachidah Yuniartika, Agus Sudaryanto, Abi Muhlisin, Dian Hudiyawati, Dimas Ria Angga Pribadi
    Open Access Macedonian Journal of Medical Sciences.2021; 9(E): 906.     CrossRef
  • Yoga nidra practice shows improvement in sleep in patients with chronic insomnia: A randomized controlled trial
    KARUNA DATTA, MANJARI TRIPATHI, MANSI VERMA, DEEPIKA MASIWAL, HRUDA NANDA MALLICK
    The National Medical Journal of India.2021; 34: 143.     CrossRef
  • MANAGEMENT THROUGH AYURVEDIC MEDICATIONS AND LIFESTYLE MODIFICATION (PATHYASEVANA AND YOGASANA) IN A CASE OF POST-COVID COMPLICATION DIABETES MELLITUS (TYPE 2 DM): A SINGLE CASE STUDY
    Prajakta D. Nimje, Vidya Wasnik (Thatere), Sumeeta Jain
    International Ayurvedic Medical Journal.2021; 9(10): 2619.     CrossRef
  • Efficacy of palliative herbal decoction (Darvyadi Kwatha) with lifestyle modification in the management of prediabetes (Prameha): a single-arm clinical trial
    Uttamram Yadav, SantoshK Bhatted
    Journal of Indian System of Medicine.2021; 9(4): 265.     CrossRef
  • Role of yoga as an adjuvant therapy in the management of metabolic syndrome – A randomized control pilot study
    Rajasekaran Balaji, Meena Ramanathan, AnandaBalayogi Bhavanani
    Yoga Mimamsa.2021; 53(2): 116.     CrossRef
  • Effect of an 8-Week Yoga-Based Lifestyle Intervention on Psycho-Neuro-Immune Axis, Disease Activity, and Perceived Quality of Life in Rheumatoid Arthritis Patients: A Randomized Controlled Trial
    Surabhi Gautam, Manoj Kumar, Uma Kumar, Rima Dada
    Frontiers in Psychology.2020;[Epub]     CrossRef
  • Type 2 diabetes mellitus: pathogenesis and genetic diagnosis
    D. Himanshu, Wahid Ali, Mohd Wamique
    Journal of Diabetes & Metabolic Disorders.2020; 19(2): 1959.     CrossRef
  • Prevalence and Awareness of Stroke and Other Comorbidities Associated with Diabetes in Northwest India
    Vivek Podder, Vinod Srivastava, Saurabh Kumar, Raghuram Nagarathna, Madhava Sai Sivapuram, Navneet Kaur, Kanupriya Sharma, Amit Kumar Singh, Neeru Malik, Akshay Anand, Hongasandra R. Nagendra
    Journal of Neurosciences in Rural Practice.2020; 11: 467.     CrossRef
  • Patterns of concomitant use of Ayurveda and conventional anti-diabetic formulations - Experiences at a tertiary care Ayurveda hospital, India
    R Galib, Poonam Dang, Vijay Kumar, Rakesh Rana, Pramod Yadav, PK Prajapati
    AYU (An international quarterly journal of research in Ayurveda).2020; 41(2): 72.     CrossRef
  • A perspective on yoga as a preventive strategy for coronavirus disease 2019
    R Nagarathna, HR Nagendra, Vijaya Majumdar
    International Journal of Yoga.2020; 13(2): 89.     CrossRef
  • Effect of Ayurveda intervention, lifestyle modification and Yoga in prediabetic and type 2 diabetes under the National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS)–AYUSH integration project
    Ramavtar Sharma, VinodKumar Shahi, Shruti Khanduri, Arun Goyal, Suhas Chaudhary, RakeshKumar Rana, Richa Singhal, Narayanam Srikanth, KartarSingh Dhiman
    AYU (An international quarterly journal of research in Ayurveda).2019; 40(1): 8.     CrossRef
  • Type 2 diabetes mellitus, physical activity, yoga and telomere length: A literature review
    Reepa A. Ughreja, Reena A. Ughreja
    Journal of Metabolic Health.2019;[Epub]     CrossRef
Close layer
Thyroid
Radioactive Iodine-Refractory Differentiated Thyroid Cancer and Redifferentiation Therapy
Jierui Liu, Yanqing Liu, Yansong Lin, Jun Liang
Endocrinol Metab. 2019;34(3):215-225.   Published online September 26, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.3.215
  • 10,557 View
  • 318 Download
  • 59 Web of Science
  • 56 Crossref
AbstractAbstract PDFPubReader   ePub   

The retained functionality of the sodium iodide symporter (NIS) expressed in differentiated thyroid cancer (DTC) cells allows the further utilization of post-surgical radioactive iodine (RAI) therapy, which is an effective treatment for reducing the risk of recurrence, and even the mortality, of DTC. Whereas, the dedifferentiation of DTC could influence the expression of functional NIS, thereby reducing the efficacy of RAI therapy in advanced DTC. Genetic alternations (such as BRAF and the rearranged during transfection [RET]/papillary thyroid cancer [PTC] rearrangement) have been widely reported to be prominently responsible for the onset, progression, and dedifferentiation of PTC, mainly through activating the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling cascades. These genetic alternations have been suggested to associate with the reduced expression of iodide-handling genes in thyroid cancer, especially the NIS gene, disabling iodine uptake and causing resistance to RAI therapy. Recently, novel and promising approaches aiming at various targets have been attempted to restore the expression of these iodine-metabolizing genes and enhance iodine uptake through in vitro studies and studies of RAI-refractory (RAIR)-DTC patients. In this review, we discuss the regulation of NIS, known mechanisms of dedifferentiation including the MAPK and PI3K pathways, and the current status of redifferentiation therapy for RAIR-DTC patients.

Citations

Citations to this article as recorded by  
  • Long-term impact of prophylactic central neck dissection in non-invasive classic papillary thyroid carcinoma
    Zehang Xu, Zhuochao Mao, Shitu Chen, Zhe Mo, Jie Zhou, Zhendong Chen, Rasa Zarnegar, Thomas J. Fahey III, Weibin Wang, Lisong Teng
    European Journal of Surgical Oncology.2024; 50(1): 107305.     CrossRef
  • The role of MAPK, notch and Wnt signaling pathways in papillary thyroid cancer: Evidence from a systematic review and meta-analyzing microarray datasets employing bioinformatics knowledge and literature
    Elham Amjad, Solmaz Asnaashari, Ali Jahanban-Esfahlan, Babak Sokouti
    Biochemistry and Biophysics Reports.2024; 37: 101606.     CrossRef
  • Diagnostic Performance of [18F]TFB PET/CT Compared with Therapeutic Activity [131I]Iodine SPECT/CT and [18F]FDG PET/CT in Recurrent Differentiated Thyroid Carcinoma
    David Ventura, Matthias Dittmann, Florian Büther, Michael Schäfers, Kambiz Rahbar, Daniel Hescheler, Michael Claesener, Philipp Schindler, Burkhard Riemann, Robert Seifert, Wolfgang Roll
    Journal of Nuclear Medicine.2024; 65(2): 192.     CrossRef
  • Lipid‐Peptide‐mRNA Nanoparticles Augment Radioiodine Uptake in Anaplastic Thyroid Cancer
    Qinglin Li, Lizhuo Zhang, Jiayan Lang, Zhuo Tan, Qingqing Feng, Fei Zhu, Guangna Liu, Zhangguo Ying, Xuefei Yu, He Feng, Heqing Yi, Qingliang Wen, Tiefeng Jin, Keman Cheng, Xiao Zhao, Minghua Ge
    Advanced Science.2023;[Epub]     CrossRef
  • Case Report: Regaining radioiodine uptake following PRRT in radioiodine-refractory thyroid cancer: A new re-differentiation strategy?
    Bentolhoda Hadad, Emran Askari, Seyed Rasoul Zakavi, Kamran Aryana, Soheila Erfani, Pegah Sahafi, Nima Nabavi, Atena Aghaee
    Frontiers in Nuclear Medicine.2023;[Epub]     CrossRef
  • Radioiodine therapy in advanced differentiated thyroid cancer: Resistance and overcoming strategy
    Yujia Liu, Jiafeng Wang, Xiaoping Hu, Zongfu Pan, Tong Xu, Jiajie Xu, Liehao Jiang, Ping Huang, Yiwen Zhang, Minghua Ge
    Drug Resistance Updates.2023; 68: 100939.     CrossRef
  • The role of miR-139-5p in radioiodine-resistant thyroid cancer
    V. Pecce, M. Sponziello, A. Verrienti, G. Grani, L. Abballe, S. Bini, S. Annunziata, G. Perotti, M. Salvatori, L. Zagaria, V. Maggisano, D. Russo, S. Filetti, C. Durante
    Journal of Endocrinological Investigation.2023; 46(10): 2079.     CrossRef
  • Anti-Cancer SERCA Inhibitors Targeting Sorafenib-Resistant Human Papillary Thyroid Carcinoma
    Hang-Seok Chang, Yonjung Kim, So Young Lee, Hyeok Jun Yun, Ho-Jin Chang, Ki Cheong Park
    International Journal of Molecular Sciences.2023; 24(8): 7069.     CrossRef
  • Modulation of EZH2 Activity Induces an Antitumoral Effect and Cell Redifferentiation in Anaplastic Thyroid Cancer
    Diego Claro de Mello, Kelly Cristina Saito, Marcella Maringolo Cristovão, Edna Teruko Kimura, Cesar Seigi Fuziwara
    International Journal of Molecular Sciences.2023; 24(9): 7872.     CrossRef
  • Effects of apitherapy against salivary gland disorder after radioactive iodine therapy for differentiated thyroid cancer
    Kenta Nomura, Michihiro Nakayama, Atsutaka Okizaki
    Annals of Nuclear Medicine.2023; 37(8): 462.     CrossRef
  • Could Oxidative Stress Play a Role in the Development and Clinical Management of Differentiated Thyroid Cancer?
    Maria Kościuszko, Angelika Buczyńska, Adam Jacek Krętowski, Anna Popławska-Kita
    Cancers.2023; 15(12): 3182.     CrossRef
  • The efficacy and safety in radioactive iodine refractory thyroid cancer patients treated with sorafenib
    Yuanna Ling, Xiaoli Xiong, Jiaxin Luo, Quanliang Zou, Pan Chen, Liqin Pan, Man Long, Huijuan Feng, Wei Ouyang
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Advances in the molecular mechanism and targeted therapy of radioactive-iodine refractory differentiated thyroid cancer
    Lu Zhang, Zhi Li, Meng Zhang, Huangren Zou, Yuke Bai, Yanlin Liu, Juan Lv, Ling Lv, Pengjie Liu, Zhiyong Deng, Chao Liu
    Medical Oncology.2023;[Epub]     CrossRef
  • Multicenter Randomized Double-Blind Phase III Trial of Donafenib in Progressive Radioactive Iodine-Refractory Differentiated Thyroid Cancer
    Yansong Lin, Shukui Qin, Hui Yang, Feng Shi, Aimin Yang, Xingmin Han, Bin Liu, Zhiyong Li, Qinghai Ji, Lijun Tang, Zhiyong Deng, Yong Ding, Wei Fu, Xianhe Xie, Linfa Li, Xiaohui He, Zhongwei Lv, Qingjie Ma, Zan Shen, Zhuming Guo, Zhendong Chen, Yali Cui,
    Clinical Cancer Research.2023; 29(15): 2791.     CrossRef
  • A review of Glycogen Synthase Kinase-3 (GSK3) inhibitors for cancers therapies
    Riya Thapa, Gaurav Gupta, Asif Ahmad Bhat, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Shakir Saleem, Ruqaiyah Khan, Najla Altwaijry, Harish Dureja, Sachin Kumar Singh, Kamal Dua
    International Journal of Biological Macromolecules.2023; 253: 127375.     CrossRef
  • Discovery of New Anti-Cancer Agents against Patient-Derived Sorafenib-Resistant Papillary Thyroid Cancer
    Yuna Kim, Hyeok Jun Yun, Kyung Hwa Choi, Chan Wung Kim, Jae Ha Lee, Raymond Weicker, Seok-Mo Kim, Ki Cheong Park
    International Journal of Molecular Sciences.2023; 24(22): 16413.     CrossRef
  • Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas
    A.C.L. Mortensen, J. Imgenberg-Kreuz, D. Spiegelberg, J. Botling, M. Nestor
    Heliyon.2023; 9(12): e22594.     CrossRef
  • Canine follicular cell and medullary thyroid carcinomas: Immunohistochemical characterization
    Jana Jankovic, Eve Tièche, Martina Dettwiler, Kerstin Hahn, Stephanie Scheemaeker, Martin Kessler, Sylvie Daminet, Sven Rottenberg, Miguel Campos
    Veterinary Pathology.2023;[Epub]     CrossRef
  • Advancements in theranostic applications: exploring the role of fibroblast activation protein inhibition tracers in enhancing thyroid health assessment
    Yuhua Wang, Ye Liu, Huixia Geng, Wanchun Zhang
    EJNMMI Research.2023;[Epub]     CrossRef
  • Tyrosine Kinase Inhibitors for Radioactive Iodine Refractory Differentiated Thyroid Cancer
    Christos Cortas, Haris Charalambous
    Life.2023; 14(1): 22.     CrossRef
  • microRNA-181a promotes the oncogene S100A2 and enhances papillary thyroid carcinoma growth by mediating the expression of histone demethylase KDM5C
    Y. Wang, H. Ye, Y. Yang, J. Li, A. Cen, L. Zhao
    Journal of Endocrinological Investigation.2022; 45(1): 17.     CrossRef
  • Systemic Therapy in Thyroid Cancer
    Amit Kumar Agrawal, Vanita Noronha, Vijay Patil, Nandini Menon, Akhil Kapoor, Anuradha Chougule, Pratik Chandrani, Kumar Prabhash
    Indian Journal of Surgical Oncology.2022; 13(1): 68.     CrossRef
  • Small activating RNA-activated NIS gene promotes 131I uptake and inhibits thyroid cancer via AMPK/mTOR pathway
    Li Jia, Yan Chen, Fukun Chen, Juan Lv, Yanling Li, Fei Hou, Zhixian Yang, Zhiyong Deng
    Pathology - Research and Practice.2022; 229: 153735.     CrossRef
  • Effects of Anti-Cancer Drug Sensitivity-Related Genetic Differences on Therapeutic Approaches in Refractory Papillary Thyroid Cancer
    Hyeok Jun Yun, Minki Kim, Sang Yong Kim, Sungsoon Fang, Yonjung Kim, Hang-Seok Chang, Ho-Jin Chang, Ki Cheong Park
    International Journal of Molecular Sciences.2022; 23(2): 699.     CrossRef
  • Comprehensive Analysis of the Prognosis and Drug Sensitivity of Differentiation-Related lncRNAs in Papillary Thyroid Cancer
    Wenlong Wang, Ning Bai, Xinying Li
    Cancers.2022; 14(5): 1353.     CrossRef
  • American Head and Neck Society Endocrine Surgery Section and International Thyroid Oncology Group consensus statement on mutational testing in thyroid cancer: Defining advanced thyroid cancer and its targeted treatment
    David C. Shonka, Alan Ho, Ashish V. Chintakuntlawar, Jessica L. Geiger, Jong C. Park, Nagashree Seetharamu, Sina Jasim, Amr H. Abdelhamid Ahmed, Keith C. Bible, Marcia S. Brose, Maria E. Cabanillas, Kirsten Dabekaussen, Louise Davies, Dora Dias‐Santagata,
    Head & Neck.2022; 44(6): 1277.     CrossRef
  • State of the Art in the Current Management and Future Directions of Targeted Therapy for Differentiated Thyroid Cancer
    Horatiu Silaghi, Vera Lozovanu, Carmen Emanuela Georgescu, Cristina Pop, Bogdana Adriana Nasui, Adriana Florinela Cătoi, Cristina Alina Silaghi
    International Journal of Molecular Sciences.2022; 23(7): 3470.     CrossRef
  • Targeting GLI1 Transcription Factor for Restoring Iodine Avidity with Redifferentiation in Radioactive-Iodine Refractory Thyroid Cancers
    Ji Min Oh, Ramya Lakshmi Rajendran, Prakash Gangadaran, Chae Moon Hong, Ju Hye Jeong, Jaetae Lee, Byeong-Cheol Ahn
    Cancers.2022; 14(7): 1782.     CrossRef
  • The Role of the Kinase Inhibitors in Thyroid Cancers
    Francesca Cuomo, Claudio Giani, Gilda Cobellis
    Pharmaceutics.2022; 14(5): 1040.     CrossRef
  • In Silico Screening and Validation of PDGFRA Inhibitors Enhancing Radioiodine Sensitivity in Thyroid Cancer
    Xuefei Yu, Xuhang Zhu, Lizhuo Zhang, Jiang-Jiang Qin, Chunlai Feng, Qinglin Li
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Clinical and prognosis value of the number of metastatic lymph nodes in patients with papillary thyroid carcinoma
    Ling Zhan, Hong-fang Feng, Xi-zi Yu, Ling-rui Li, Jun-long Song, Yi Tu, Jing-ping Yuan, Chuang Chen, Sheng-rong Sun
    BMC Surgery.2022;[Epub]     CrossRef
  • Radionuclide 131I-labeled albumin-indocyanine green nanoparticles for synergistic combined radio-photothermal therapy of anaplastic thyroid cancer
    Xuemei Zhang, Ziyu Yan, Zhaowei Meng, Ning Li, Qiang Jia, Yiming Shen, Yanhui Ji
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Re-evaluation of the role of autophagy in thyroid cancer treatment
    Darya Kazakova, Mika Shimamura, Tomomi Kurashige, Koichiro Hamada, Yuji Nagayama
    Endocrine Journal.2022; 69(7): 847.     CrossRef
  • Radiopharmaceutical Treatments for Cancer Therapy, Radionuclides Characteristics, Applications, and Challenges
    Suliman Salih, Ajnas Alkatheeri, Wijdan Alomaim, Aisyah Elliyanti
    Molecules.2022; 27(16): 5231.     CrossRef
  • Potential Therapeutic Agents against Paclitaxel—And Sorafenib-Resistant Papillary Thyroid Carcinoma
    Seok-Mo Kim, Keunwan Park, Jin Hong Lim, Hyeok Jun Yun, Sang Yong Kim, Kyung Hwa Choi, Chan Wung Kim, Jae Ha Lee, Raymond Weicker, Cheol-Ho Pan, Ki Cheong Park
    International Journal of Molecular Sciences.2022; 23(18): 10378.     CrossRef
  • Research Progress of BRAF V600E Gene Mutation in Papillary Thyroid Carcinoma
    延泽 刘
    Advances in Clinical Medicine.2022; 12(09): 8499.     CrossRef
  • Sinomenine Hydrochloride Promotes TSHR-Dependent Redifferentiation in Papillary Thyroid Cancer
    Jing Zhang, Aomei Zhao, Xi Jia, Xinru Li, Yiqian Liang, Yan Liu, Xin Xie, Xijie Qu, Qi Wang, Yuemin Zhang, Rui Gao, Yan Yu, Aimin Yang
    International Journal of Molecular Sciences.2022; 23(18): 10709.     CrossRef
  • miR-451a suppresses papillary thyroid cancer cell proliferation and invasion and facilitates apoptosis through targeting DCBLD2 and AKT1
    Jiuting Tan, Chunpu Li, Lijue Ren, Xiaohui Zhu, Fei Hua, Yuming Fu
    Molecular and Cellular Probes.2022; 66: 101863.     CrossRef
  • Anxiety and depression status prior to radioactive iodine therapy among differentiated thyroid cancer patients during the COVID‑19 pandemic
    Tingting Qiao, Dingwei Gao, Junyu Tong, Yun Shen, Jiayue Ma, Zhongwei Lv, Dan Li
    Supportive Care in Cancer.2022; 30(12): 10169.     CrossRef
  • Different Expression of Thyroid-Specific Proteins in Thyroid Cancer Cells between 2-Dimensional (2D) and 3-Dimensional (3D) Culture Environment
    Ji Min Oh, Prakash Gangadaran, Ramya Lakshmi Rajendran, Chae Moon Hong, Jaetae Lee, Byeong-Cheol Ahn
    Cells.2022; 11(22): 3559.     CrossRef
  • Histone acetylation modifications: A potential targets for the diagnosis and treatment of papillary thyroid cancer
    Chongyang Chen, Jingfang Liu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Effect to Therapy of Sodium-Iodine Symporter Expression by Alpha-Ray Therapeutic Agent via Sodium/Iodine Symporter
    Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Tadashi Watabe, Kazuhiro Ooe, Takashi Yoshimura, Atsushi Toyoshima, Yang Wang, Hiromitsu Haba, Koichi Fukase
    International Journal of Molecular Sciences.2022; 23(24): 15509.     CrossRef
  • Reinducing Radioiodine-Sensitivity in Radioiodine-Refractory Thyroid Cancer Using Lenvatinib (RESET): Study Protocol for a Single-Center, Open Label Phase II Trial
    Maaike Dotinga, Dennis Vriens, Floris H. P. van Velden, Mette K. Stam, Jan W. T. Heemskerk, Petra Dibbets-Schneider, Martin Pool, Daphne D. D. Rietbergen, Lioe-Fee de Geus-Oei, Ellen Kapiteijn
    Diagnostics.2022; 12(12): 3154.     CrossRef
  • Non-Apoptotic Programmed Cell Death in Thyroid Diseases
    Feihong Ji, Xinguang Qiu
    Pharmaceuticals.2022; 15(12): 1565.     CrossRef
  • Donafenib in Progressive Locally Advanced or Metastatic Radioactive Iodine-Refractory Differentiated Thyroid Cancer: Results of a Randomized, Multicenter Phase II Trial
    Yan-Song Lin, Hui Yang, Yong Ding, Yi-Zhuang Cheng, Feng Shi, Jian Tan, Zhi-Yong Deng, Zhen-Dong Chen, Rong-Fu Wang, Qing-Hai Ji, Rui Huang, Lin-Fa Li
    Thyroid.2021; 31(4): 607.     CrossRef
  • Radioactive iodine therapy may not improve disease‐specific survival in follicular variant papillary thyroid cancer without distant metastasis: A propensity score‐matched analysis
    Xiaofei Wang, Xun Zheng, Jingqiang Zhu, Zhihui Li, Tao Wei
    Head & Neck.2021; 43(6): 1730.     CrossRef
  • Serum CYFRA 21.1 Level Predicts Disease Course in Thyroid Cancer with Distant Metastasis
    Chaiho Jeong, Jeongmin Lee, Hyukjin Yoon, Jeonghoon Ha, Min-Hee Kim, Ja-Seong Bae, Chan-Kwon Jung, Jeong-Soo Kim, Moo-Il Kang, Dong-Jun Lim
    Cancers.2021; 13(4): 811.     CrossRef
  • Radio-Iodide Treatment: From Molecular Aspects to the Clinical View
    Antonio De la Vieja, Garcilaso Riesco-Eizaguirre
    Cancers.2021; 13(5): 995.     CrossRef
  • Advances of Nanomedicine in Radiotherapy
    Wei Liu, Bo Chen, Haocheng Zheng, Yun Xing, Guiyuan Chen, Peijie Zhou, Liting Qian, Yuanzeng Min
    Pharmaceutics.2021; 13(11): 1757.     CrossRef
  • Treatment Effect of Combining Lenvatinib and Vemurafenib for BRAF Mutated Anaplastic Thyroid Cancer
    Chae Moon Hong, Ji Min Oh, Prakash Gangadaran, Ramya Lakshmi Rajendran, Byeong-Cheol Ahn
    International Journal of Thyroidology.2021; 14(2): 127.     CrossRef
  • TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells
    Márcia Faria, Rita Domingues, Francisca Paixão, Maria João Bugalho, Paulo Matos, Ana Luísa Silva, Salvatore Papa
    PLOS ONE.2020; 15(2): e0228794.     CrossRef
  • Novel Targeted Therapies for Metastatic Thyroid Cancer—A Comprehensive Review
    Mohammad Al-Jundi, Shilpa Thakur, Sriram Gubbi, Joanna Klubo-Gwiezdzinska
    Cancers.2020; 12(8): 2104.     CrossRef
  • Managing radioiodine refractory thyroid cancer: the role of dosimetry and redifferentiation on subsequent I-131 therapy
    Maaike Dotinga, Dennis Vriens, Floris van Velden, Linda Heijmen, James Nagarajah, Rodney Hicks, Ellen Kapiteijn, Lioe-Fee de Geus-Oei
    The Quarterly Journal of Nuclear Medicine and Molecular Imaging.2020;[Epub]     CrossRef
  • Mediator complex subunit 16 is down-regulated in papillary thyroid cancer, leading to increased transforming growth factor-β signaling and radioiodine resistance
    Hongwei Gao, Peirong Bai, Lin Xiao, Mengjia Shen, Qiuxiao Yu, Yuanyuan Lei, Wenting Huang, Xiang Lin, Xinyi Zheng, Tao Wei, Yong Jiang, Feng Ye, Hong Bu
    Journal of Biological Chemistry.2020; 295(31): 10726.     CrossRef
  • Peptide Receptor Radionuclide Therapy in Patients With Differentiated Thyroid Cancer
    Dong Yun Lee, Yong-il Kim
    Clinical Nuclear Medicine.2020; 45(8): 604.     CrossRef
  • Combination of peroxisome proliferator–activated receptor gamma and retinoid X receptor agonists induces sodium/iodide symporter expression and inhibits cell growth of human thyroid cancer cells
    Jui-Yu Chen, Jane-Jen Wang, Hsin-Chen Lee, Chin-Wen Chi, Chen-Hsen Lee, Yi-Chiung Hsu
    Journal of the Chinese Medical Association.2020; 83(10): 923.     CrossRef
Close layer
Original Articles
Bone Metabolism
Age-Related Changes in the Prevalence of Osteoporosis according to Gender and Skeletal Site: The Korea National Health and Nutrition Examination Survey 2008-2010
Jongseok Lee, Sungwha Lee, Sungok Jang, Ohk Hyun Ryu
Endocrinol Metab. 2013;28(3):180-191.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.180
  • 5,032 View
  • 76 Download
  • 56 Crossref
AbstractAbstract PDFPubReader   
Background

The incidence of osteoporosis and its related fractures are expected to increase significantly in the rapidly aging Korean population. Reliable data on the prevalence of this disease is essential for treatment planning. However, sparse data on Korean patients is available.

Methods

We analyzed data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2008 to 2010. Bone mineral density (BMD) was measured at the femoral neck and lumbar spine using dual-energy X-ray absorptiometry. Osteopenia and osteoporosis were diagnosed according to the World Health Organization T-score criteria. We analyzed the BMD data of 17,208 people (men, 7,837; women, 9,368).

Results

The adjusted prevalence of osteoporosis was 7.8% in men versus 37.0% in women. No significant difference was observed in the prevalence of osteopenia between genders (men, 47.0%; women, 48.7%). The prevalence of osteoporosis in men in their 50s was 4.0%, in their 60s was 7.2%, in their 70s was 15.1%, and in their 80s was 26.7%. The figures in women were 15.2%, 36.5%, 62.7%, and 85.8%, respectively. The age group with the maximal BMD differed between genders. In the men, 20s had the highest value in all the skeletal sites. However, in the women, the maximal BMD in the femoral neck, lumbar spine, and the total hip was observed in their 20s, 30s, and 40s, respectively. The onset age of osteoporosis differed between genders. Osteoporosis in the femoral neck began at 55 years in the women and at 60 years in the men.

Conclusion

The prevalence of osteoporosis in Korea was significantly high. In addition, the age-related changes in the prevalence of osteoporosis differed according to gender and skeletal site.

Citations

Citations to this article as recorded by  
  • The entrancing role of dietary polyphenols against the most frequent aging‐associated diseases
    Muhammad Ajmal Shah, Hafiza Ishmal Faheem, Ayesha Hamid, Rimsha Yousaf, Muhammad Haris, Uzma Saleem, Ghulam Mujtaba Shah, Reem H. Alhasani, Norah A. Althobaiti, Ifat Alsharif, Ana Sanches Silva
    Medicinal Research Reviews.2024; 44(1): 235.     CrossRef
  • Chronic health conditions after childhood Langerhans cell histiocytosis: Results from the Swiss Childhood Cancer Survivor Study
    Tomáš Sláma, Luzius Mader, Maša Žarković, Reta Malär, Alexandra Schifferli, Nicolas X. von der Weid, Claudia E. Kuehni, Christina Schindera
    Journal of Cancer Survivorship.2024;[Epub]     CrossRef
  • Osteoporosis and its associated factors among patients attending Manakamana Hospital, Chitwan, Nepal
    Shankar Dhakal, Kalpana Sharma, Kishor Adhikari, Alisha Joshi, Sunita Poudyal, Chiranjivi Adhikari
    PLOS ONE.2024; 19(2): e0289517.     CrossRef
  • Closed-wedge high tibial osteotomy is more advantageous to maintain the correction than open-wedge high tibial osteotomy in osteopenic patients
    Sang Jun Song, Kyoung Ho Yoon, Kang Il Kim, Cheol Hee Park
    Knee Surgery, Sports Traumatology, Arthroscopy.2023; 31(4): 1563.     CrossRef
  • Influence of the Changes in the Bone Mineral Density on the Guided Bone Regeneration Using Bioinspired Grafts: A Systematic Review and Meta-analysis
    Angelica M. Castillo-Paz, Brandon A. Correa-Piña, Harol D. Martinez-Hernandez, Omar M. Gomez-Vazquez, Dorian F. Cañon-Davila, Luis F. Zubieta-Otero, Sandra M. Londoño-Restrepo, Esther Perez-Torrero, Mario E. Rodriguez-Garcia
    Biomedical Materials & Devices.2023; 1(1): 162.     CrossRef
  • Effective Treatment of Femur Diaphyseal Fracture with Compression Plate – A Finite Element and In Vivo Study Comparing the Healing Outcomes of Nailing and Plating
    Sandeep Rathor, Rashmi Uddanwadiker, Nandram Saryam, Ashutosh Apte
    Indian Journal of Orthopaedics.2023; 57(1): 146.     CrossRef
  • Vertebral trabecular bone texture analysis in opportunistic MRI and CT scan can distinguish patients with and without osteoporotic vertebral fracture: A preliminary study
    François Poullain, Pierre Champsaur, Vanessa Pauly, Paul Knoepflin, Thomas Le Corroller, Maud Creze, Martine Pithioux, David Bendahan, Daphne Guenoun
    European Journal of Radiology.2023; 158: 110642.     CrossRef
  • INFLUENCE OF FIXATION STABILIZATION ON FEMUR DIAPHYSEAL FRACTURE HEALING — A FINITE ELEMENT STUDY COMPARING HEALING OUTCOMES OF NAILING AND PLATING
    SANDEEP RATHOR, RASHMI UDDANWADIKER, ASHUTOSH APTE
    Journal of Mechanics in Medicine and Biology.2023;[Epub]     CrossRef
  • Vitamin C Deficiency Deteriorates Bone Microarchitecture and Mineralization in a Sex-Specific Manner in Adult Mice
    Stéphane Blouin, Farzaneh Khani, Phaedra Messmer, Paul Roschger, Markus A. Hartmann, Andre J. van Wijnen, Roman Thaler, Barbara M. Misof
    Journal of Bone and Mineral Research.2023; 38(10): 1509.     CrossRef
  • Comparison of HU histogram analysis and BMD for proximal femoral fragility fracture assessment: a retrospective single-center case–control study
    Sun-Young Park, Hong Il Ha, Injae Lee, Hyun Kyung Lim
    European Radiology.2022; 32(3): 1448.     CrossRef
  • Effect of osteoporosis-related reduction in the mechanical properties of bone on the acetabular fracture during a sideways fall: A parametric finite element approach
    Shahab Khakpour, Amir Esrafilian, Petri Tanska, Mika E. Mononen, Rami K. Korhonen, Timo Jämsä, Ewa Tomaszewska
    PLOS ONE.2022; 17(2): e0263458.     CrossRef
  • Evaluation of the bone mineral density in the Mexican female population using the Radiofrequency Echographic Multi Spectrometry (REMS) technology
    Rosales-Ortiz Sergio, Rivera García Elaín Nayelli
    Archives of Osteoporosis.2022;[Epub]     CrossRef
  • Non‐fermented tea consumption protects against osteoporosis among Chinese male elders using the Taiwan biobank database
    Chiao-Lin Hsu, Wei-Lun Huang, Hung-Hui Chen, Jerry Cheng-Yen Lai
    Scientific Reports.2022;[Epub]     CrossRef
  • Prevalence of osteopenic syndrome and osteoporosis among residents of the older age group of Kyrgyzstan
    T. J. Tagaev, F. E. Imanalieva, S. M. Mamatov, E. Marishbek kyzy, B. T. Tagaeva
    Acta Biomedica Scientifica.2022; 7(4): 130.     CrossRef
  • Do antihypertensive medications effect the mandibular cortical bone thickness? A study using cone beam computed tomography images
    Brett Spenrath, Antonia Kolokythas
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2022; 134(6): 687.     CrossRef
  • Topical application of the plant extract SDTL-E in ovariectomized rats: A potential new approach for treating osteoporosis
    Hui-Yuan Shih, Jun-Hua Lu, Ai-Hua Xiong, Juliana Man-Wai Tse, Ben Siu-Tak Wong
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Measures of physical performance as a predictor of fracture risk independent of BMD: The Chungju metabolic disease cohort study
    Yejee Lim, Jeonghoon Ha, Kun Ho Yoon, Ki Hyun Baek, Moo-Il Kang
    Bone.2021; 145: 115878.     CrossRef
  • Alendronate use in older patients with reduced renal function: challenges and opportunities in clinical practice
    N. Naganathar, W. -P. Yau, Z. H. Mok, Z. Y. F. Tan, S. T. H. Chew
    Osteoporosis International.2021; 32(10): 1981.     CrossRef
  • Efficacy and Safety of Denosumab in Osteoporosis or Low Bone Mineral Density Postmenopausal Women
    Yi Chen, Jun Zhu, Yiqin Zhou, Jinhui Peng, Bo Wang
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Chronic active non-lethal human-type tuberculosis in a high royal Bavarian officer of Napoleonic times–a mummy study
    Andreas G. Nerlich, Sonja M. Kirchhoff, Stephanie Panzer, Christine Lehn, Beatrice E. Bachmeier, Birgit Bayer, Katja Anslinger, Pascale Röcker, Oliver K. Peschel, Mark Spigelman
    PLOS ONE.2021; 16(5): e0249955.     CrossRef
  • Sex-related differences in bone metabolism in osteoporosis observational study
    Kyu Hwan Choi, Jong Ho Lee, Dong Gyu Lee
    Medicine.2021; 100(21): e26153.     CrossRef
  • Analysis of Bone Mineral Density of Ankle Fracture Patients
    Tae Hyung Kim, Jae Hyung Lee, Seung-Hwan Park
    Journal of the Korean Orthopaedic Association.2021; 56(4): 334.     CrossRef
  • The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis
    Nader Salari, Hooman Ghasemi, Loghman Mohammadi, Mohammad hasan Behzadi, Elham Rabieenia, Shamarina Shohaimi, Masoud Mohammadi
    Journal of Orthopaedic Surgery and Research.2021;[Epub]     CrossRef
  • Systemic oxidative stress in old rats is associated with both osteoporosis and cognitive impairment
    María Luz Torres, Nahuel Ezequiel Wanionok, Antonio Desmond McCarthy, Gustavo Ramón Morel, Juan Manuel Fernández
    Experimental Gerontology.2021; 156: 111596.     CrossRef
  • Association of Sarcopenia with Osteopenia and Osteoporosis in Community-Dwelling Older Korean Adults: A Cross-Sectional Study
    Do-Youn Lee, Sunghoon Shin
    Journal of Clinical Medicine.2021; 11(1): 129.     CrossRef
  • Prevalence of osteopenia and osteoporosis in elderly and senile individuals of Kyrgyzstan
    Tugolbai J. Tagaev
    Science and Innovations in Medicine.2021; 7(1): 26.     CrossRef
  • Young cancer survivors have lower bone mineral density compared with healthy controls: a nationwide population-based study in Korea
    Hyoeun Kim, Sunmi Yoo, Seung Guk Park
    Scientific Reports.2020;[Epub]     CrossRef
  • Underestimated fracture risk in postmenopausal women—application of the hybrid intervention threshold
    Y. Wang, S. Yu, C. Hsu, C. Tsai, T. Cheng
    Osteoporosis International.2020; 31(3): 475.     CrossRef
  • Does the skull Hounsfield unit predict shunt dependent hydrocephalus after decompressive craniectomy for traumatic acute subdural hematoma?
    In-Suk Bae, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Kyu-Sun Choi, Myung-Hoon Han, Michael C. Burger
    PLOS ONE.2020; 15(4): e0232631.     CrossRef
  • The health and economic burden of osteoporotic fractures in Singapore and the potential impact of increasing treatment rates through more pharmacological options
    Manju Chandran, Tang Ching Lau, Isabelle Gagnon-Arpin, Alexandru Dobrescu, Wenshan Li, Man Yee Mallory Leung, Narendra Patil, Zhongyun Zhao
    Archives of Osteoporosis.2019;[Epub]     CrossRef
  • Prevalence and Predictors of Osteoporosis Among the Chinese Population in Klang Valley, Malaysia
    Shaanthana Subramaniam, Chin-Yi Chan, Ima-Nirwana Soelaiman, Norazlina Mohamed, Norliza Muhammad, Fairus Ahmad, Mohd Rizal Abd Manaf, Pei-Yuen Ng, Nor Aini Jamil, Kok-Yong Chin
    Applied Sciences.2019; 9(9): 1820.     CrossRef
  • Elevated Red Blood Cell Distribution Width Is Associated with Morphometric Vertebral Fracture in Community-Dwelling Older Adults, Independent of Anemia, Inflammation, and Nutritional Status: The Korean Urban Rural Elderly (KURE) Study
    Namki Hong, Chang Oh Kim, Yoosik Youm, Jin-Young Choi, Hyeon Chang Kim, Yumie Rhee
    Calcified Tissue International.2019; 104(1): 26.     CrossRef
  • Different impacts of dementia on two-year mortality after osteosynthesis and hemiarthroplasty in treating geriatric hip fractures
    Yu-Cheng Lai, Pei-Ling Tang, Tsu-Jen Kuo, Chien-Jen Hsu
    Archives of Gerontology and Geriatrics.2018; 79: 116.     CrossRef
  • Association between metabolic syndrome and blepharoptosis in the Korean adults: the Korea National Health and Nutrition Examination Survey 2010–2012
    Changhyun Koh, Geunyeong Kim, Kyungdo Han, Juwan Park
    Journal of Cosmetic Medicine.2018; 2(2): 85.     CrossRef
  • The Relationship of Serum Serotonin Levels to the Rate of Bone Loss and Fractures in Men
    Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Ho Song, Moo-Il Kang, Ki-Hyun Baek
    Journal of Clinical Densitometry.2018; 21(1): 35.     CrossRef
  • Utilization of Osteoporosis-Related Health Services: Use of Data from the Korean National Health Insurance Database 2008–2012
    Tae Yang Yu, Hyemin Cho, Tae-Young Kim, Yong-Chan Ha, Sunmee Jang, Ha Young Kim
    Journal of Korean Medical Science.2018;[Epub]     CrossRef
  • Association between liver enzymes and bone mineral density in Koreans: a cross-sectional study
    Ho Jeong Do, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-riong Kim, Dongwoo Nam, Eun-Jung Kim, Yeoncheol Park, Kristin Suhr, In-Hyuk Ha
    BMC Musculoskeletal Disorders.2018;[Epub]     CrossRef
  • The prevalence of osteoporosis and the rate of bone loss in Korean adults: the Chungju metabolic disease cohort (CMC) study
    Y. Lim, K. Jo, H.-S. Ha, H.-W. Yim, K.-H. Yoon, W.-C. Lee, H.-Y. Son, K. H. Baek, M.-I. Kang
    Osteoporosis International.2017; 28(4): 1453.     CrossRef
  • Strong familial association of bone mineral density between parents and offspring: KNHANES 2008–2011
    H. S. Choi, J. H. Park, S. H. Kim, S. Shin, M. J. Park
    Osteoporosis International.2017; 28(3): 955.     CrossRef
  • Gender- and age-group-specific associations between physical performance and bone mineral density, falls, and osteoporotic fractures in Koreans: the Chungju Metabolic Disease Cohort study
    Yejee Lim, Kyunghee Kim, Sun-Hee Ko, Kwanhoon Cho, Eun-Hee Jang, Seung-Hwan Lee, Dong Jun Lim, Ki Hyun Baek, Hee-Sung Ha, Mi Sun Park, Hyeon-Woo Yim, Won-Chul Lee, Kun-Ho Yoon, Ho Young Son, Ki Won Oh, Moo-Il Kang
    Journal of Bone and Mineral Metabolism.2016; 34(3): 336.     CrossRef
  • Males seropositive for hepatitis B surface antigen are at risk of lower bone mineral density: the 2008–2010 Korea National Health and Nutrition Examination Surveys
    Myong Ki Baeg, Seung Kew Yoon, Sun-Hye Ko, Kyung-Do Han, Hye Jin Choi, Si Hyun Bae, Jong Young Choi, Myung-Gyu Choi
    Hepatology International.2016; 10(3): 470.     CrossRef
  • Age- and Sex-Specific Relationships between Household Income, Education, and Diabetes Mellitus in Korean Adults: The Korea National Health and Nutrition Examination Survey, 2008-2010
    So-Ra Kim, Kyungdo Han, Jin-Young Choi, Jennifer Ersek, Junxiu Liu, Sun-Jin Jo, Kang-Sook Lee, Hyeon Woo Yim, Won-Chul Lee, Yong Gyu Park, Seung-Hwan Lee, Yong-Moon Park, C. Mary Schooling
    PLOS ONE.2015; 10(1): e0117034.     CrossRef
  • A novel criterion for identifying metabolically obese but normal weight individuals using the product of triglycerides and glucose
    S-H Lee, K Han, H K Yang, H-S Kim, J-H Cho, H-S Kwon, Y-M Park, B-Y Cha, K-H Yoon
    Nutrition & Diabetes.2015; 5(4): e149.     CrossRef
  • Hydrogeochemistry of the drinking water sources of Derebogazi Village (Kahramanmaras) and their effects on human health
    Yusuf Uras, Yagmur Uysal, Tugba Atilan Arikan, Alican Kop, Mustafa Caliskan
    Environmental Geochemistry and Health.2015; 37(3): 475.     CrossRef
  • Lower serum zinc levels are associated with unhealthy metabolic status in normal-weight adults: The 2010 Korea National Health and Nutrition Examination Survey
    H.K. Yang, S.H. Lee, K. Han, B. Kang, S.Y. Lee, K.H. Yoon, H.S. Kwon, Y.M. Park
    Diabetes & Metabolism.2015; 41(4): 282.     CrossRef
  • The effects of the Korean reference value on the prevalence of osteoporosis and the prediction of fracture risk
    Sungwha Lee, Moon-Gi Choi, Jaemyung Yu, Ohk-Hyun Ryu, Hyung Joon Yoo, Sung-Hee Ihm, Doo-Man Kim, Eun-Gyung Hong, Kyutae Park, Myungjin Choi, Hyunhee Choi
    BMC Musculoskeletal Disorders.2015;[Epub]     CrossRef
  • Gender Difference in Osteoporosis Prevalence, Awareness and Treatment: Based on the Korea National Health and Nutrition Examination Survey 2008~2011
    Yunmi Kim, Jung Hwan Kim, Dong Sook Cho
    Journal of Korean Academy of Nursing.2015; 45(2): 293.     CrossRef
  • The effects of thyrotropin-suppressing therapy on bone metabolism in patients with well-differentiated thyroid carcinoma
    Mee Kyoung Kim, Kyung-Jin Yun, Min-Hee Kim, Dong-Jun Lim, Hyuk-Sang Kwon, Ki-Ho Song, Moo-Il Kang, Ki Hyun Baek
    Bone.2015; 71: 101.     CrossRef
  • Prevalence and clinical characteristics of blepharoptosis in patients with diabetes in the Korea National Health and Nutrition Examination Survey (KNHANES) 2009–2010
    Seong-Su Moon, Young-Sil Lee
    Endocrine.2015; 48(2): 504.     CrossRef
  • Biomechanical rationale for implant choices in femoral neck fracture fixation in the non-elderly
    Michalis Panteli, Paul Rodham, Peter V. Giannoudis
    Injury.2015; 46(3): 445.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • Discordance in Diagnosis of Osteoporosis by Skeletal Site in Korean Women: KNHANES 2008-2010
    Jongseok Lee, Sungwha Lee
    Journal of the Korea Academia-Industrial cooperation Society.2014; 15(3): 1590.     CrossRef
  • Effect of Transdermal Estrogen Therapy on Bone Mineral Density in Postmenopausal Korean Women
    Hyo Jeong Kim, Yoon Kyung Oh, Ji Soo Lee, Dong-Yun Lee, DooSeok Choi, Byung-Koo Yoon
    Journal of Menopausal Medicine.2014; 20(3): 111.     CrossRef
  • New Reference Data on Bone Mineral Density and the Prevalence of Osteoporosis in Korean Adults Aged 50 Years or Older: The Korea National Health and Nutrition Examination Survey 2008-2010
    Kyung-Shik Lee, Su-Hyun Bae, Seung Hwa Lee, Jungun Lee, Dong Ryul Lee
    Journal of Korean Medical Science.2014; 29(11): 1514.     CrossRef
  • Two Sides of Obesity: Metabolic Syndrome and Osteoporosis in Elderly Women, Gangwon-do, Korea
    Sungok Jang, Sungwha Lee, Jongseok Lee
    Korean Journal of Health Education and Promotion.2014; 31(1): 13.     CrossRef
  • Testosterone Replacement Therapy and Bone Mineral Density in Men with Hypogonadism
    Se Hwa Kim
    Endocrinology and Metabolism.2014; 29(1): 30.     CrossRef
Close layer
Thyroid
Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies
Shinje Moon, Hye Soo Chung, Jae Myung Yu, Hyung Joon Yoo, Jung Hwan Park, Dong Sun Kim, Young Joo Park
Endocrinol Metab. 2018;33(4):473-484.   Published online November 30, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.4.473
  • 7,829 View
  • 113 Download
  • 56 Web of Science
  • 55 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

Epidemiological studies have suggested an association between Hashimoto thyroiditis (HT) and papillary thyroid cancer (PTC) development. Other studies, however, have reported a protective role of HT against PTC progression. Through this updated meta-analysis, we aimed to clarify the effects of HT on the progression of PTC.

Methods

We searched citation databases, including PubMed and Embase, for relevant studies from inception to September 2017. From these studies, we calculated the pooled odds ratios (ORs) of clinicopathologic features and the relative risk (RR) of PTC recurrence with 95% confidence intervals (CIs) using the Mantel-Haenszel method. Additionally, the Higgins I2 statistic was used to test for heterogeneity.

Results

The meta-analysis included 71 published studies with 44,034 participants, among whom 11,132 had HT. We observed negative associations between PTC with comorbid HT and extrathyroidal extension (OR, 0.74; 95% CI, 0.68 to 0.81), lymph node metastasis (OR, 0.82; 95% CI, 0.72 to 0.94), distant metastasis (OR, 0.49; 95% CI, 0.32 to 0.76), and recurrence (RR, 0.50; 95% CI, 0.41 to 0.61).

Conclusion

In this meta-analysis, PTC patients with HT appeared to exhibit more favorable clinicopathologic characteristics and a better prognosis than those without HT.

Citations

Citations to this article as recorded by  
  • Malignancy risk of indeterminate lymph node at the central compartment in patients with thyroid cancer and concomitant sonographic thyroiditis
    Jung Hyo Rhim, Ji Ye Lee, Sun‐Won Park, Younghen Lee, So Lyung Jung, Tae Jin Yun, Eun Ju Ha, Jung Hwan Baek, Jinna Kim, Dong Gyu Na, Ji‐hoon Kim
    Head & Neck.2024;[Epub]     CrossRef
  • Hashimoto Thyroiditis and Mortality in Patients with Differentiated Thyroid Cancer: The National Epidemiologic Survey of Thyroid Cancer in Korea and Meta-Analysis
    Injung Yang, Jae Myung Yu, Hye Soo Chung, Yoon Jung Kim, Yong Kyun Roh, Min Kyu Choi, Sung-ho Park, Young Joo Park, Shinje Moon
    Endocrinology and Metabolism.2024;[Epub]     CrossRef
  • Interaction of BANCR in the relationship between Hashimoto’s thyroiditis and papillary thyroid carcinoma expression patterns and possible molecular mechanisms
    Jiabo Zhang, Lingli Yao, Yu Guo
    The Journal of Gene Medicine.2024;[Epub]     CrossRef
  • Association between Thyroid Cancer Treatment Outcomes and the Presence of Autoimmune Thyroiditis
    Jie Liu
    Clinical Thyroidology®.2024; 36(1): 26.     CrossRef
  • Risk prediction for central lymph node metastasis in isolated isthmic papillary thyroid carcinoma by nomogram: A retrospective study from 2010 to 2021
    Yu Zhao, Wei Shi, Fang Dong, Xiuhua Wang, Chong Lu, Chunping Liu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • The evaluation of locoregional tumoral involvement in the cooccurrence of hashimoto thyroiditis with papillary thyroid cancer: a case controlled study
    Shirzad Nasiri, Seyed Mostafa Meshkati Yazd, Mahsa Gholami, Sepehr Shahriarirad, Sina Sharghi, Reza Shahriarirad
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • Hashimoto’s Thyroiditis: A Protective Factor against Recurrence in BRAF-Wild Type Differentiated Thyroid Carcinoma
    Peter P. Issa, Mahmoud Omar, Yusef Buti, Mohamed Aboueisha, Ruhul Munshi, Mohammad Hussein, Muhib Haidari, Graham Blair, Chad P. Issa, Mohamed Shama, Eman Toraih, Emad Kandil
    Cancers.2023; 15(8): 2371.     CrossRef
  • VITAMIN D AND AUTOIMMUNE THYROIDITIS
    K. V. Pivtorak, O. V Ivanhuk O. V
    Bulletin of Problems Biology and Medicine.2023; 1(1): 44.     CrossRef
  • Does the Association of Hashimoto's Thyroiditis with Differentiated Thyroid Cancer Really Have a Protective Role?
    Ahmet Numan Demir, Zehra Kara, Cem Sulu, Serhat Uysal, Serdar Sahin, Guldana Zulfaliyeva, Oznur Aydin Atar, Nahida Valikhanova, Tulin Ozturk, Hande Mefkure Ozkaya, Mustafa Sait Gonen
    Hormone and Metabolic Research.2023; 55(06): 388.     CrossRef
  • Ultrasound, laboratory and histopathological insights in diagnosing papillary thyroid carcinoma in a paediatric population: a single centre follow-up study between 2000-2022
    Dominika Januś, Małgorzata Wójcik, Anna Taczanowska-Niemczuk, Aleksandra Kiszka-Wiłkojć, Monika Kujdowicz, Małgorzata Czogała, Wojciech Górecki, Jerzy B. Starzyk
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Early Post-operative Stimulated Serum Thyroglobulin: Role in Preventing Unnecessary Radioactive Iodine Treatment in Low to Intermediate Risk Papillary Thyroid Cancer
    Havva Sezer, Dilek Yazıcı, Tarık Terzioğlu, Serdar Tezelman, Hande Bulut Canbaz, Aslıhan Yerlikaya, Mehmet Onur Demirkol, Yersu Kapran, Bülent Çolakoğlu, Eda Nur Çilingiroğlu, Faruk Alagöl
    The American Surgeon™.2023; 89(12): 5996.     CrossRef
  • 2023 Korean Thyroid Association Management Guidelines for Patients with Thyroid Nodules
    Young Joo Park, Eun Kyung Lee, Young Shin Song, Soo Hwan Kang, Bon Seok Koo, Sun Wook Kim, Dong Gyu Na, Seung-Kuk Baek, So Won Oh, Min Kyoung Lee, Sang-Woo Lee, Young Ah Lee, Yong Sang Lee, Ji Ye Lee, Dong-Jun Lim, Leehi Joo, Yuh-Seog Jung, Chan Kwon Jung
    International Journal of Thyroidology.2023; 16(1): 1.     CrossRef
  • Clonal redemption of B cells in cancer
    Tyler R. McCaw, Serena Y. Lofftus, Joseph G. Crompton
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Prevalence and Impact of BRAF mutation in patients with concomitant papillary thyroid carcinoma and Hashimoto’s thyroiditis: a systematic review with meta-analysis
    Lukasz Janicki, Agastya Patel, Jarosław Jendrzejewski, Andrzej Hellmann
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • The role of vascular endothelial growth factor in the development of papillary thyroid carcinoma in patients with lymphocytic thyroiditis
    Nese E. GULCELIK, Safak AKIN, Kadriye AYDIN, Cisel AYDIN MERICOZ, Yesim G. GULER TEZEL, Aydan USMAN
    Minerva Endocrinology.2023;[Epub]     CrossRef
  • Chronic Lymphocytic Thyroiditis and Aggressiveness of Pediatric Differentiated Thyroid Cancer
    Richard M. Yeker, Amber D. Shaffer, Pushpa Viswanathan, Selma F. Witchel, Kevin Mollen, Linwah Yip, Sara E. Monaco, Umamaheswar Duvvuri, Jeffrey P. Simons
    The Laryngoscope.2022; 132(8): 1668.     CrossRef
  • Bisphenol A drives di(2-ethylhexyl) phthalate promoting thyroid tumorigenesis via regulating HDAC6/PTEN and c-MYC signaling
    Xuan Zhang, Nan Guo, Hao Jin, Renqi Liu, Zhen Zhang, Cheng Cheng, Zhijun Fan, Guopei Zhang, Mingyang Xiao, Shengwen Wu, Yuejiao Zhao, Xiaobo Lu
    Journal of Hazardous Materials.2022; 425: 127911.     CrossRef
  • Squamous Differentiation in the Thyroid: Metaplasia, Neoplasia, or Bystander?
    Meagan A. Chambers, Peter M. Sadow, Darcy A. Kerr
    International Journal of Surgical Pathology.2022; 30(4): 385.     CrossRef
  • Vitamin D Implications and Effect of Supplementation in Endocrine Disorders: Autoimmune Thyroid Disorders (Hashimoto’s Disease and Grave’s Disease), Diabetes Mellitus and Obesity
    Dorina Galușca, Mihaela Simona Popoviciu, Emilia Elena Babeș, Mădălina Vidican, Andreea Atena Zaha, Vlad Victor Babeș, Alexandru Daniel Jurca, Dana Carmen Zaha, Florian Bodog
    Medicina.2022; 58(2): 194.     CrossRef
  • Central Compartment Lymph Nodes Have Distinct Metastatic Patterns in Different Age Groups
    Caigu Yan, Xianghui He, Zuoyu Chen, Yizeng Wang
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Synchronous occurrence of papillary thyroid microcarcinoma, medullary thyroid carcinoma and Hashimoto thyroiditis in a single thyroid: A case report with literature review
    Ari M. Abdullah, Rawa M. Ali, Karzan M. Salih, Karukh K. Mohammed, Fahmi H. Kakamad, Abdulwahid M. Salih
    International Journal of Surgery Case Reports.2022; 93: 106888.     CrossRef
  • Benign and malignant thyroid nodules with autoimmune thyroiditis
    Georgia N. Kassi, Catherine C. Evangelopoulou, Konstantinos D. Papapostolou, Helen J. Karga
    Archives of Endocrinology and Metabolism.2022;[Epub]     CrossRef
  • Association between Hashimoto thyroiditis and clinical outcomes of papillary thyroid carcinoma: A meta-analysis
    Qizhi Tang, Weiyu Pan, Liangyue Peng, Francis Moore
    PLOS ONE.2022; 17(6): e0269995.     CrossRef
  • A Narrative Review of Preventive Central Lymph Node Dissection in Patients With Papillary Thyroid Cancer - A Necessity or an Excess
    David D. Dolidze, Alexey V. Shabunin, Robert B. Mumladze, Arshak V. Vardanyan, Serghei D. Covantsev, Alexander M. Shulutko, Vasiliy I. Semikov, Khalid M. Isaev, Airazat M. Kazaryan
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Role of papillary thyroid carcinoma patients with Hashimoto thyroiditis: evaluation of oxidative stress and inflammatory markers
    Natália Medeiros Dias Lopes, Hannah Hamada Mendonça Lens, Walison Augusto da Silva Brito, Julya Karen Bianchi, Poliana Camila Marinello, Rubens Cecchini, André Armani, Alessandra Lourenço Cecchini
    Clinical and Translational Oncology.2022; 24(12): 2366.     CrossRef
  • Emerging trends and hot spots in autoimmune thyroiditis research from 2000 to 2022: A bibliometric analysis
    Qiuxian Li, Wanyu Yang, Jiashu Li, Zhongyan Shan
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • The Immune Landscape of Papillary Thyroid Cancer in the Context of Autoimmune Thyroiditis
    Fabiana Pani, Paola Caria, Yoshinori Yasuda, Miyara Makoto, Stefano Mariotti, Laurence Leenhardt, Solmaz Roshanmehr, Patrizio Caturegli, Camille Buffet
    Cancers.2022; 14(17): 4287.     CrossRef
  • Comprehensive analysis of lncRNA-mediated ceRNA regulatory networks and key genes associated with papillary thyroid cancer coexistent with Hashimoto’s thyroiditis
    Yuepeng Zhang, Yueli Tian
    BMC Endocrine Disorders.2022;[Epub]     CrossRef
  • Elastographic Evaluation of Thyroid Nodules in Children and Adolescents with Hashimoto’s Thyroiditis and Nodular Goiter with Reference to Cytological and/or Histopathological Diagnosis
    Hanna Borysewicz-Sańczyk, Beata Sawicka, Filip Bossowski, Janusz Dzięcioł, Artur Bossowski
    Journal of Clinical Medicine.2022; 11(21): 6339.     CrossRef
  • Prognostic value of the preoperative and early trends in postoperative serum thyroglobulin antibody levels among patients with papillary thyroid carcinoma and concomitant Hashimoto’s thyroiditis
    Siyuan Xu, Hui Huang, Jiaxin Qian, Xiaolei Wang, Zhengang Xu, Shaoyan Liu, Jie Liu
    Endocrine.2022; 80(2): 392.     CrossRef
  • What has changed in the last 20 years in the postoperative specimen findings of the papillary thyroid cancer cases? A retrospective analysis
    Burak Bakar, Pınar Taşar, Turkay Kırdak, Sadık Kılıçturgay
    Turkish Journal of Surgery.2022; 38(4): 345.     CrossRef
  • A nomogram model based on the preoperative clinical characteristics of papillary thyroid carcinoma with Hashimoto's thyroiditis to predict central lymph node metastasis
    Wanjun Zhao, Linye He, Jingqiang Zhu, Anping Su
    Clinical Endocrinology.2021; 94(2): 310.     CrossRef
  • The Association of Histologically Proven Chronic Lymphocytic Thyroiditis with Clinicopathological Features, Lymph Node Metastasis, and Recurrence Rates of Differentiated Thyroid Cancer
    Berna İmge Aydoğan, Adile Begüm Bahçecioğlu Mutlu, Seher Yüksel, Sevim Güllü, Rıfat Emral, Özgür Demir, Mustafa Şahin, Vedia Tonyukuk Gedik, Demet Çorapçıoğlu, Serpil Dizbay Sak, Murat Faik Erdoğan
    Endocrine Pathology.2021; 32(2): 280.     CrossRef
  • Beneficial autoimmunity improves cancer prognosis
    Laurence Zitvogel, Claude Perreault, Olivera J. Finn, Guido Kroemer
    Nature Reviews Clinical Oncology.2021; 18(9): 591.     CrossRef
  • Influence Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: Hashimoto’s Thyroiditis Has a Weak Effect on Central or Lateral Lymph Node Metastasis
    Liguang Zhou, Gang Chen, Lei Sheng, Nan Liu, Bin Zhang, Qingdong Zeng, Bo Chen
    Cancer Management and Research.2021; Volume 13: 3953.     CrossRef
  • Implications of a background of Hashimoto’s thyroiditis on the current conservative surgical trend towards papillary thyroid carcinoma
    Shadi Hamouri, Sohail Bakkar, Almoutuz Aljaafreh, Mohammed Bani Hani, Hussein Heis, Ghazi Qasaimeh, Nasr Alrabadi, Wisam Al Gargaz, Haitham Odat, Yazan Alkurdi, Tarek Manasreh, Mohammad Matalka, Moamin Badwan
    Updates in Surgery.2021; 73(5): 1931.     CrossRef
  • Thyroid nodules in childhood‐onset Hashimoto's thyroiditis: Frequency, risk factors, follow‐up course and genetic alterations of thyroid cancer
    Yun Jeong Lee, Yeon Jin Cho, You Joung Heo, Eun‐Jae Chung, Young Hun Choi, Jong‐Il Kim, Young Joo Park, Choong Ho Shin, Young Ah Lee
    Clinical Endocrinology.2021; 95(4): 638.     CrossRef
  • Prevalence of Hashimoto Thyroiditis in Adults With Papillary Thyroid Cancer and Its Association With Cancer Recurrence and Outcomes
    Siyuan Xu, Hui Huang, Jiaxin Qian, Yang Liu, Ying Huang, Xiaolei Wang, Shaoyan Liu, Zhengang Xu, Jie Liu
    JAMA Network Open.2021; 4(7): e2118526.     CrossRef
  • The Effects of Chronic Lymphocytic Thyroiditis on Clinicopathologic Factors in Papillary Thyroid Cancer
    Davut Sakiz, Muhammed Erkam Sencar, Murat Calapkulu, Ilknur Ozturk Unsal, Levent Aktas, Bekir Ucan, Mustafa Ozbek, Erman Cakal
    Endocrine Practice.2021; 27(12): 1199.     CrossRef
  • Significance of DMBT1 in Papillary Thyroid Carcinoma Concurrent With Hashimoto’s Thyroiditis
    Xiao-xiong Gan, Ya-yi Li, Si-jin Li, Shi-sen Mo, Jian-hua Feng, Fei Shen, Wen-song Cai, Ye-qian Lai, Bo Xu
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Pre-existing Thyroiditis Ameliorates Papillary Thyroid Cancer: Insights From a New Mouse Model
    Fabiana Pani, Yoshinori Yasuda, Giulia Di Dalmazi, Paulina Chalan, Kathleen Gabrielson, Luigi Adamo, Elena Sabini, Stefano Mariotti, Patrizio Caturegli
    Endocrinology.2021;[Epub]     CrossRef
  • Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
    Juliette Paillet, Céleste Plantureux, Sarah Lévesque, Julie Le Naour, Gautier Stoll, Allan Sauvat, Pamela Caudana, Jimena Tosello Boari, Norma Bloy, Sylvie Lachkar, Isabelle Martins, Paule Opolon, Andrea Checcoli, Agathe Delaune, Noémie Robil, Pierre de l
    Journal of Experimental Medicine.2021;[Epub]     CrossRef
  • Papillary Thyroid Cancer Prognosis: An Evolving Field
    Salvatore Ulisse, Enke Baldini, Augusto Lauro, Daniele Pironi, Domenico Tripodi, Eleonora Lori, Iulia Catalina Ferent, Maria Ida Amabile, Antonio Catania, Filippo Maria Di Matteo, Flavio Forte, Alberto Santoro, Piergaspare Palumbo, Vito D’Andrea, Salvator
    Cancers.2021; 13(21): 5567.     CrossRef
  • Overexpression of PD-L1 in Papillary Carcinoma and Its Association with Clinicopathological Variables
    Servet KOCAÖZ, Gülay TURAN
    Düzce Tıp Fakültesi Dergisi.2021; 23(3): 252.     CrossRef
  • Correlation Between Hashimoto's Thyroiditis–Related Thyroid Hormone Levels and 25-Hydroxyvitamin D
    Guanqun Chao, Yue Zhu, Lizheng Fang
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Oncological impact of hypothyroidism and levothyroxine supplementation following hemithyroidectomy in patients with papillary thyroid carcinoma
    Dongbin Ahn, Gil J. Lee, Jin H. Sohn, Jae H. Jeon
    Head & Neck.2020; 42(5): 1004.     CrossRef
  • Suspicious ultrasound characteristics correlate with multiple factors that predict central lymph node metastasis of papillary thyroid carcinoma: Significant role of HBME-1
    Li Jianming, Liu Jibin, Qian Linxue
    European Journal of Radiology.2020; 123: 108801.     CrossRef
  • Unexpected high‐risk pathologic features following thyroidectomy in the chinese immigrant population
    Arvind K. Badhey, Erin Moshier, Ameya Jategaonkar, Anni Wong, Kristen Echanique, Raymond L. Chai
    The Laryngoscope.2020; 130(7): 1844.     CrossRef
  • Hashimoto's thyroiditis attenuates progression of papillary thyroid carcinoma: deciphering immunological links
    Oksana Sulaieva, Oleksii Selezniov, Dmytro Shapochka, Nataliia Belemets, Oleksandr Nechay, Yelizaveta Chereshneva, Dibakhan Tsomartova, Marina Ivanova
    Heliyon.2020; 6(1): e03077.     CrossRef
  • Changes in Treg numbers and activity in papillary thyroid carcinoma with and without Hashimoto’s thyroiditis
    Na Zhao, Xin Liu, Chao Wu, Yuanchao Liu, Xiangnan Zhao, Xianghui He
    Journal of International Medical Research.2020; 48(4): 030006052091922.     CrossRef
  • Genetic relationship between Hashimoto`s thyroiditis and papillary thyroid carcinoma with coexisting Hashimoto`s thyroiditis
    Ohoud Subhi, Hans-Juergen Schulten, Nadia Bagatian, Roa'a Al-Dayini, Sajjad Karim, Sherin Bakhashab, Reem Alotibi, Alaa Al-Ahmadi, Manar Ata, Aisha Elaimi, Saad Al-Muhayawi, Majid Mansouri, Khalid Al-Ghamdi, Osman Abdel Hamour, Awatif Jamal, Jaudah Al-Mag
    PLOS ONE.2020; 15(6): e0234566.     CrossRef
  • Hashimoto's thyroiditis as a risk factor for thyroid cancer
    Ulla Feldt-Rasmussen
    Current Opinion in Endocrinology, Diabetes & Obesity.2020; 27(5): 364.     CrossRef
  • Predictive Factors of Recurrence for Multifocal Papillary Thyroid Microcarcinoma With Brafv600e Mutation: A Single Center Study of 1,207 Chinese Patients
    Shuai Xue, Li Zhang, Peisong Wang, Jia Liu, Yue Yin, Meishan Jin, Liang Guo, Yuhua Zhou, Guang Chen
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Hashimotos’ thyroiditis: Epidemiology, pathogenesis, clinic and therapy
    Francesca Ragusa, Poupak Fallahi, Giusy Elia, Debora Gonnella, Sabrina Rosaria Paparo, Claudia Giusti, Leonid P. Churilov, Silvia Martina Ferrari, Alessandro Antonelli
    Best Practice & Research Clinical Endocrinology & Metabolism.2019; 33(6): 101367.     CrossRef
  • Características anatomopatológicas del carcinoma papilar de tiroides en especimenes con y sin tiroiditis linfocitica crónica.
    Carlos Osorio Covo, Jorge Ballestas Barrera, Jorge Martínez Castro, Zully Acevedo Meza, Diego Barrios Castellar, Francisco Herrera Sáenz, Cesar Redondo Bermúdez, Katherine Redondo De Oro
    Revista Ciencias Biomédicas.2019; 8(2): 32.     CrossRef
Close layer
Review Articles
Thyroid
Genome-Wide Association Studies of Autoimmune Thyroid Diseases, Thyroid Function, and Thyroid Cancer
Yul Hwangbo, Young Joo Park
Endocrinol Metab. 2018;33(2):175-184.   Published online June 21, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.2.175
  • 7,811 View
  • 136 Download
  • 55 Web of Science
  • 54 Crossref
AbstractAbstract PDFPubReader   ePub   

Thyroid diseases, including autoimmune thyroid diseases and thyroid cancer, are known to have high heritability. Family and twin studies have indicated that genetics plays a major role in the development of thyroid diseases. Thyroid function, represented by thyroid stimulating hormone (TSH) and free thyroxine (T4), is also known to be partly genetically determined. Before the era of genome-wide association studies (GWAS), the ability to identify genes responsible for susceptibility to thyroid disease was limited. Over the past decade, GWAS have been used to identify genes involved in many complex diseases, including various phenotypes of the thyroid gland. In GWAS of autoimmune thyroid diseases, many susceptibility loci associated with autoimmunity (human leukocyte antigen [HLA], protein tyrosine phosphatase, non-receptor type 22 [PTPN22], cytotoxic T-lymphocyte associated protein 4 [CTLA4], and interleukin 2 receptor subunit alpha [IL2RA]) or thyroid-specific genes (thyroid stimulating hormone receptor [TSHR] and forkhead box E1 [FOXE1]) have been identified. Regarding thyroid function, many susceptibility loci for levels of TSH and free T4 have been identified through genome-wide analyses. In GWAS of differentiated thyroid cancer, associations at FOXE1, MAP3K12 binding inhibitory protein 1 (MBIP)-NK2 homeobox 1 (NKX2-1), disrupted in renal carcinoma 3 (DIRC3), neuregulin 1 (NRG1), and pecanex-like 2 (PCNXL2) have been commonly identified in people of European and Korean ancestry, and many other susceptibility loci have been found in specific populations. Through GWAS of various thyroid-related phenotypes, many susceptibility loci have been found, providing insights into the pathogenesis of thyroid diseases and disease co-clustering within families and individuals.

Citations

Citations to this article as recorded by  
  • A new, all‐encompassing aetiology of type 1 diabetes
    Piet C. de Groen
    Immunology.2024; 171(1): 77.     CrossRef
  • The role of primary cilia in thyroid diseases
    Zijiao Tian, Xinlin Li, Xue Yu, Shuxin Yan, Jingwei Sun, Wenxin Ma, Xiaoyun Zhu, Yang Tang
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Exome sequencing to explore the possibility of predicting genetic susceptibility to the joint occurrence of polycystic ovary syndrome and Hashimoto’s thyroiditis
    Natalia Zeber-Lubecka, Katarzyna Suchta, Maria Kulecka, Anna Kluska, Magdalena Piątkowska, Michal J. Dabrowski, Katarzyna Jankowska, Monika Grymowicz, Roman Smolarczyk, Ewa E. Hennig
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Molecular Mechanisms in Autoimmune Thyroid Disease
    Hernando Vargas-Uricoechea
    Cells.2023; 12(6): 918.     CrossRef
  • Identification of multiple novel susceptibility genes associated with autoimmune thyroid disease
    Xueying Liu, Yahu Miao, Chao Liu, Wan Lu, Qing Feng, Qiu Zhang
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Novel Susceptibility Genes Drive Familial Non-Medullary Thyroid Cancer in a Large Consanguineous Kindred
    Pierre Majdalani, Uri Yoel, Tayseer Nasasra, Merav Fraenkel, Alon Haim, Neta Loewenthal, Raz Zarivach, Eli Hershkovitz, Ruti Parvari
    International Journal of Molecular Sciences.2023; 24(9): 8233.     CrossRef
  • An Optimized Flow Cytometric Method to Demonstrate the Differentiation Stage-Dependent Ca2+ Flux Responses of Peripheral Human B Cells
    Anna Bajnok, Timea Serény-Litvai, Viktória Temesfői, Jasper Nörenberg, Róbert Herczeg, Ambrus Kaposi, Timea Berki, Emese Mezosi
    International Journal of Molecular Sciences.2023; 24(10): 9107.     CrossRef
  • FOXE1 Contributes to the Development of Psoriasis by Regulating WNT5A
    Meng Liu, Guanfei Zhang, Ziyang Wang, Xinyi Liu, Ke He, Ruiting Luo, Qiqi Duan, Ruimin Bai, Yuqian Wang, Wenqian Du, Yan Zheng, Yongping Shao
    Journal of Investigative Dermatology.2023; 143(12): 2366.     CrossRef
  • Correlation analysis of HHV-6A viral load and anti-TPO antibody levels in patients with Hashimoto's thyroiditis
    Noorossadat Seyyedi, Fariba Esfandiyari, Gholamreza Rafiei Dehbidi, Ali Farhadi, Farahnaz Zare, Sepide Namdari, Golrokh Bahmani, Banafsheh Rastegari, Farzaneh Zarghampoor, Abbas Behzad-Behbahani
    Future Virology.2023; 18(8): 527.     CrossRef
  • Primary cell cultures for the personalized therapy in aggressive thyroid cancer of follicular origin
    Poupak Fallahi, Silvia Martina Ferrari, Giusy Elia, Francesca Ragusa, Armando Patrizio, Sabrina Rosaria Paparo, Gianni Marone, Maria Rosaria Galdiero, Giovanni Guglielmi, Rudy Foddis, Alfonso Cristaudo, Alessandro Antonelli
    Seminars in Cancer Biology.2022; 79: 203.     CrossRef
  • The Relationship between PTPN22 R620W Polymorphisms and the Susceptibility to Autoimmune Thyroid Diseases: An Updated Meta-analysis
    Huaiyong Wu, Siyuan Wan, Mengying Qu, Bingxuan Ren, Lixiang Liu, Hongmei Shen
    Immunological Investigations.2022; 51(2): 438.     CrossRef
  • Identification of Transcriptional Pattern Related to Immune Cell Infiltration With Gene Co-Expression Network in Papillary Thyroid Cancer
    Meiye Li, Jimei Zhang, Zongjing Zhang, Ying Qian, Wei Qu, Zhaoshun Jiang, Baochang Zhao
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank
    Sean J. Jurgens, Seung Hoan Choi, Valerie N. Morrill, Mark Chaffin, James P. Pirruccello, Jennifer L. Halford, Lu-Chen Weng, Victor Nauffal, Carolina Roselli, Amelia W. Hall, Matthew T. Oetjens, Braxton Lagerman, David P. vanMaanen, Goncalo Abecasis, Xiao
    Nature Genetics.2022; 54(3): 240.     CrossRef
  • Factors affecting recurrence in subacute granulomatous thyroiditis
    Çiğdem Tura Bahadir, Merve Yilmaz, Elif Kiliçkan
    Archives of Endocrinology and Metabolism.2022;[Epub]     CrossRef
  • Shared etiology of type 1 diabetes and Hashimoto’s thyroiditis: a population-based twin study
    Jakob Skov, Ralf Kuja-Halkola, Patrik K E Magnusson, Soffia Gudbjörnsdottir, Olle Kämpe, Sophie Bensing
    European Journal of Endocrinology.2022; 186(6): 677.     CrossRef
  • High Prevalence of Common Human Viruses in Thyroid Tissue
    Therese Weider, Angelo Genoni, Francesco Broccolo, Trond H. Paulsen, Knut Dahl-Jørgensen, Antonio Toniolo, Sara Salehi Hammerstad
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • B cells from anti-thyroid antibody positive, infertile women show hyper-reactivity to BCR stimulation
    Timea Serény-Litvai, Anna Bajnok, Viktoria Temesfoi, Jasper Nörenberg, Greta Pham-Dobor, Ambrus Kaposi, Akos Varnagy, Kalman Kovacs, Sandor Pentek, Tamas Koszegi, Emese Mezosi, Timea Berki
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • What do the structures of GCN5-containing complexes teach us about their function?
    Dominique Helmlinger, Gábor Papai, Didier Devys, László Tora
    Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms.2021; 1864(2): 194614.     CrossRef
  • Genetic Susceptibility to Joint Occurrence of Polycystic Ovary Syndrome and Hashimoto’s Thyroiditis: How Far Is Our Understanding?
    Natalia Zeber-Lubecka, Ewa E. Hennig
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Type 1 Diabetes and Autoimmune Thyroid Disease—The Genetic Link
    Lara Frommer, George J. Kahaly
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Familial Risk of Hashimoto's Thyroiditis Among First-Degree Relatives: A Population-Based Study in Korea
    Hyun Jung Kim, Sayada Zartasha Kazmi, Taeuk Kang, Seo Young Sohn, Dong-Sook Kim, Hoo Jae Hann, Hyeong Sik Ahn
    Thyroid.2021; 31(7): 1096.     CrossRef
  • Limited Genetic Overlap Between Overt Hashimoto’s Thyroiditis and Graves’ Disease in Twins: A Population-based Study
    Jakob Skov, Jan Calissendorff, Daniel Eriksson, Patrik Magnusson, Olle Kämpe, Sophie Bensing, Ralf Kuja-Halkola
    The Journal of Clinical Endocrinology & Metabolism.2021; 106(4): e1101.     CrossRef
  • Endogenous and Synthetic Regulators of the Peripheral Components of the Hypothalamo-Hypophyseal-Gonadal and -Thyroid Axes
    A. O. Shpakov
    Neuroscience and Behavioral Physiology.2021; 51(3): 332.     CrossRef
  • Programmed Cell Death-Ligand 1 (PD-L1) gene Single Nucleotide Polymorphism in Graves’ Disease and Hashimoto’s Thyroiditis in Korean Patients
    Jee Hee Yoon, Min-ho Shin, Hee Nam Kim, Wonsuk Choi, Ji Yong Park, A Ram Hong, Hee Kyung Kim, Ho-Cheol Kang
    Endocrinology and Metabolism.2021; 36(3): 599.     CrossRef
  • Predisposition to Graves’ disease and Graves’ ophthalmopathy by genetic variants of IL2RA
    Juan Du, Xin Wang, Guiqin Tan, Wenwen Wei, Fangyu Zhou, Zhongzhi Liang, Hua Li, Hongsong Yu
    Journal of Molecular Medicine.2021; 99(10): 1487.     CrossRef
  • Association of IL-1β, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population
    Zahra Heidari, Saeedeh Salimi, Mohsen Rokni, Mahnaz Rezaei, Neshat Khalafi, Mahdieh Jafari Shahroudi, Azizallah Dehghan, Mohsen Saravani, Rafael S. De Molon
    BioMed Research International.2021; 2021: 1.     CrossRef
  • Genetic polymorphisms in the PCNXL2 gene are risk factors for thyroid cancer in the Chinese population
    Runmei Hao, Peng Han, Ling Zhang, Ying Bi, Jinfeng Yan, Honghui Li, Yanxia Bai, Chongwen Xu, Baiya Li, Huajing Li
    Future Oncology.2021; 17(34): 4677.     CrossRef
  • Genetic Variants Associated with Thyroid Cancer Risk: Comprehensive Research Synopsis, Meta-Analysis, and Cumulative Epidemiological Evidence
    Ran Ran, Gang Tu, Hui Li, Hao Wang, Exian Mou, Caiyang Liu, Yuan Seng Wu
    Journal of Oncology.2021; 2021: 1.     CrossRef
  • The Identification of Three Key Genes Related to Stemness in Thyroid Carcinoma through Comprehensive Analysis
    Tonglong Zhang, Chunhong Yan, Zhengdu Ye, Xingling Yin, Tian-an Jiang
    Combinatorial Chemistry & High Throughput Screening.2021; 24(3): 423.     CrossRef
  • Епідеміологія автоімунного тиреоїдиту
    V.I. Кravchenko, О.А. Тоvkay, О.V. Rakov, М.D. Тronko
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2021; 17(2): 136.     CrossRef
  • Thyroid autoimmune disorders and cancer
    Silvia Martina Ferrari, Poupak Fallahi, Giusy Elia, Francesca Ragusa, Ilaria Ruffilli, Sabrina Rosaria Paparo, Alessandro Antonelli
    Seminars in Cancer Biology.2020; 64: 135.     CrossRef
  • Association of FCRL3 rs7528684 polymorphism with risk of Hashimoto's thyroiditis in Iranian patients
    Kurosh Kalantar, Farzad Ghandehari, Saeed Malek-Hosseini, Hossein Golmoghaddam, Davood Rostamzadeh, Mohamad Hossein Dabbaghmanesh, Zahra Amirghofran
    Meta Gene.2020; 24: 100663.     CrossRef
  • Differentiated thyroid cancer and Hashimoto thyroiditis: Utility of the Afirma gene expression classifier
    Vardan Papoian, Jennifer E. Rosen, Wen Lee, Leonard Wartofsky, Erin A. Felger
    Journal of Surgical Oncology.2020; 121(7): 1053.     CrossRef
  • Familial risks between Graves disease and Hashimoto thyroiditis and other autoimmune diseases in the population of Sweden
    Hauke Thomsen, Xinjun Li, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki
    Journal of Translational Autoimmunity.2020; 3: 100058.     CrossRef
  • Association of rs944289, rs965513, and rs1443434 in TITF1/TITF2 with Risks of Papillary Thyroid Carcinoma and with Nodular Goiter in Northern Chinese Han Populations
    Xin Zhang, Yulu Gu, Yong Li, Heran Cui, Xiaoli Liu, Hui Sun, Qiong Yu, Yaqin Yu, Yawen Liu, Siyan Zhan, Yi Cheng
    International Journal of Endocrinology.2020; 2020: 1.     CrossRef
  • FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease
    Saedis Saevarsdottir, Thorunn A. Olafsdottir, Erna V. Ivarsdottir, Gisli H. Halldorsson, Kristbjorg Gunnarsdottir, Asgeir Sigurdsson, Ari Johannesson, Jon K. Sigurdsson, Thorhildur Juliusdottir, Sigrun H. Lund, Asgeir O. Arnthorsson, Edda L. Styrmisdottir
    Nature.2020; 584(7822): 619.     CrossRef
  • Genetic relationship between Hashimoto`s thyroiditis and papillary thyroid carcinoma with coexisting Hashimoto`s thyroiditis
    Ohoud Subhi, Hans-Juergen Schulten, Nadia Bagatian, Roa'a Al-Dayini, Sajjad Karim, Sherin Bakhashab, Reem Alotibi, Alaa Al-Ahmadi, Manar Ata, Aisha Elaimi, Saad Al-Muhayawi, Majid Mansouri, Khalid Al-Ghamdi, Osman Abdel Hamour, Awatif Jamal, Jaudah Al-Mag
    PLOS ONE.2020; 15(6): e0234566.     CrossRef
  • Thyroid cancer and thyroid autoimmune disease: A review of molecular aspects and clinical outcomes
    Natália Medeiros Dias Lopes, Hannah Hamada Mendonça Lens, André Armani, Poliana Camila Marinello, Alessandra Lourenço Cecchini
    Pathology - Research and Practice.2020; 216(9): 153098.     CrossRef
  • Immune gene signature delineates a subclass of thyroid cancer with unfavorable clinical outcomes
    Jingtai Zhi, Jiaoyu Yi, Mengran Tian, Huijuan Wang, Ning Kang, Xiangqian Zheng, Ming Gao
    Aging.2020; 12(7): 5733.     CrossRef
  • VARIETY OF COMBINATIONS OF HASHIMOTO’S THYROIDITIS WITH OTHER BACKGROUND PATHOLOGY OF THYROID PARENCHEMA IN DIFFERENT FORMS OF THYROID CANCER
    Yu. I. Karachentsev, V. M. Dubovik, I. V. Gopkalova, V. V. Khaziev, S. S. Sokolova, Y. P. Korchagin, N. G. Filonenko, M. Y. Sazonov, L. V. Gerasimenko
    Bulletin of Problems Biology and Medicine.2020; 3(1): 105.     CrossRef
  • Analysis of Polymorphisms rs7093069-IL-2RA, rs7138803-FAIM2, and rs1748033-PADI4 in the Group of Adolescents With Autoimmune Thyroid Diseases
    Beata Sawicka, Hanna Borysewicz-Sańczyk, Natalia Wawrusiewicz-Kurylonek, Tommaso Aversa, Domenico Corica, Joanna Gościk, Adam Krętowski, Małgorzata Waśniewska, Artur Bossowski
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Familial associations for rheumatoid autoimmune diseases
    Hauke Thomsen, Xinjun Li, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki
    Rheumatology Advances in Practice.2020;[Epub]     CrossRef
  • Familial risks between giant cell arteritis and Takayasu arteritis and other autoimmune diseases in the population of Sweden
    Hauke Thomsen, Xinjun Li, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki
    Scientific Reports.2020;[Epub]     CrossRef
  • The Association of Obesity with Autoimmune Thyroiditis and Thyroid Function-Possible Mechanisms of Bilateral Interaction
    Agnieszka Baranowska-Bik, Wojciech Bik, Henrik Falhammar
    International Journal of Endocrinology.2020; 2020: 1.     CrossRef
  • The Risk of Recurrence of Subacute Thyroiditis Is HLA-Dependent
    Magdalena Stasiak, Bogusław Tymoniuk, Bartłomiej Stasiak, Andrzej Lewiński
    International Journal of Molecular Sciences.2019; 20(5): 1089.     CrossRef
  • FOXE1 inhibits cell proliferation, migration and invasion of papillary thyroid cancer by regulating PDGFA
    Zheng Ding, Ronghu Ke, Yong Zhang, Youben Fan, Jianxia Fan
    Molecular and Cellular Endocrinology.2019; 493: 110420.     CrossRef
  • Current Knowledge of Germline Genetic Risk Factors for the Development of Non-Medullary Thyroid Cancer
    Kinga Hińcza, Artur Kowalik, Aldona Kowalska
    Genes.2019; 10(7): 482.     CrossRef
  • Thyroid Cancer: The Quest for Genetic Susceptibility Involving DNA Repair Genes
    Santos, Gomes, Bastos, Gil, Azevedo, Ferreira, Limbert, Silva, Rueff
    Genes.2019; 10(8): 586.     CrossRef
  • Genetic Polymorphisms on 4q21.1 Contributed to the Risk of Hashimoto's Thyroiditis
    Dachao Mo, Junjiu Li, Liang Peng, Zhiyuan Liu, Jieyun Wang, Jiru Yuan
    Genetic Testing and Molecular Biomarkers.2019; 23(12): 837.     CrossRef
  • A Weighted Genetic Risk Score Using Known Susceptibility Variants to Predict Graves Disease Risk
    Yu-Ru Ma, Shuang-Xia Zhao, Lu Li, Feng Sun, Xiao-Ping Ye, Fei-Fei Yuan, Dan Jiang, Zheng Zhou, Qian-Yue Zhang, Yue-Yue Wan, Guang-Ya Zhang, Jing Wu, Rui-Jia Zhang, Ya Fang, Huai-Dong Song
    The Journal of Clinical Endocrinology & Metabolism.2019; 104(6): 2121.     CrossRef
  • Architects meets Repairers: The interplay between homeobox genes and DNA repair
    Bruno César Feltes
    DNA Repair.2019; 73: 34.     CrossRef
  • Development of a prognostic index based on an immunogenomic landscape analysis of papillary thyroid cancer
    Peng Lin, Yi-nan Guo, Lin Shi, Xiao-jiao Li, Hong Yang, Yun He, Qing Li, Yi-wu Dang, Kang-lai Wei, Gang Chen
    Aging.2019; 11(2): 480.     CrossRef
  • Selenium and Selenoproteins in Immune Mediated Thyroid Disorders
    Liliana Santos, Celestino Neves, Miguel Melo, Paula Soares
    Diagnostics.2018; 8(4): 70.     CrossRef
  • Sex-specific genetic influence on thyroid-stimulating hormone and free thyroxine levels, and interactions between measurements: KNHANES 2013–2015
    Young Ki Lee, Dong Yeob Shin, Hyejung Shin, Eun Jig Lee, Silvia Naitza
    PLOS ONE.2018; 13(11): e0207446.     CrossRef
Close layer
Thyroid
The Diagnosis and Management of Hyperthyroidism in Korea: Consensus Report of the Korean Thyroid Association
Jae Hoon Moon, Ka Hee Yi
Endocrinol Metab. 2013;28(4):275-279.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.275
  • 5,187 View
  • 67 Download
  • 54 Crossref
AbstractAbstract PDFPubReader   

Hyperthyroidism is one of the causes of thyrotoxicosis and the most common cause of hyperthyroidism in Korea is Graves disease. The diagnosis and treatment of Graves disease are different according to geographical area. Recently, the American Thyroid Association and the American Association of Clinical Endocrinologists suggested new management guidelines for hyperthyroidism. However, these guidelines are different from clinical practice in Korea and are difficult to apply. Therefore, the Korean Thyroid Association (KTA) conducted a survey of KTA members regarding the diagnosis and treatment of hyperthyroidism, and reported the consensus on the management of hyperthyroidism. In this review, we summarized the KTA report on the contemporary practice patterns in the diagnosis and management of hyperthyroidism, and compared this report with guidelines from other countries.

Citations

Citations to this article as recorded by  
  • Effect of previous administration of potassium iodine and different durations of low iodine diets for radioiodine therapy on the treatment of Graves' disease in iodine-rich areas
    Mika Tamura, Kunihiro Nakada, Haruna Iwanaga, Naotoshi Fujita, Katsuhiko Kato
    European Journal of Nuclear Medicine and Molecular Imaging.2024; 51(4): 1060.     CrossRef
  • Effects of altitude on thyroid disorders according to Chinese three-rung, ladder-like topography: national cross-sectional study
    Boshen Gong, Youmin Wang, Jin-an Zhang, Qiao Zhang, Jiajun Zhao, Jiashu Li, Xichang Wang, Yutong Han, Ziwei Yu, Chenyu Zhang, Bingcong Peng, Yumin Xing, Qiuxian Li, Ping Wang, Yongze Li, Weiping Teng, Zhongyan Shan
    BMC Public Health.2024;[Epub]     CrossRef
  • MACE and Hyperthyroidism Treated With Medication, Radioactive Iodine, or Thyroidectomy
    Carol Chiung-Hui Peng, Yu-Jie Lin, Sun Y. Lee, Shu-Man Lin, Cheng Han, Ching-Hui Loh, Huei-Kai Huang, Elizabeth N. Pearce
    JAMA Network Open.2024; 7(3): e240904.     CrossRef
  • Increased risk of incident gout in patients with hyperthyroidism: a nationwide retrospective cohort study
    Ju-Yeun Lee, So-Yeon Park, Seo Young Sohn
    Rheumatology International.2023; 44(3): 451.     CrossRef
  • The Current Status of Hyperthyroidism in Korea
    Hyemi Kwon
    Endocrinology and Metabolism.2023; 38(4): 392.     CrossRef
  • A machine learning-assisted system to predict thyrotoxicosis using patients’ heart rate monitoring data: a retrospective cohort study
    Kyubo Shin, Jongchan Kim, Jaemin Park, Tae Jung Oh, Sung Hye Kong, Chang Ho Ahn, Joon Ho Moon, Min Joo Kim, Jae Hoon Moon
    Scientific Reports.2023;[Epub]     CrossRef
  • Immunometabolic signatures predict recovery from thyrotoxic myopathy in patients with Graves' disease
    Daiki Setoyama, Ho Yeop Lee, Ji Sun Moon, Jingwen Tian, Yea Eun Kang, Ju Hee Lee, Minho Shong, Dongchon Kang, Hyon‐Seung Yi
    Journal of Cachexia, Sarcopenia and Muscle.2022; 13(1): 355.     CrossRef
  • Comparison of 99mTc Pertechnetate Thyroid Uptake Rates by Gamma Probe and Gamma Camera Methods for Differentiating Graves’ Disease and Thyroiditis
    Meihua Jin, Jonghwa Ahn, Seong-gil Jo, Jangwon Park, Min Ji Jeon, Won Gu Kim, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Jin-Sook Ryu
    Nuclear Medicine and Molecular Imaging.2022; 56(1): 42.     CrossRef
  • KSNM60 in Nuclear Endocrinology: from the Beginning to the Future
    Chae Moon Hong, Young Jin Jeong, Hae Won Kim, Byeong-Cheol Ahn
    Nuclear Medicine and Molecular Imaging.2022; 56(1): 17.     CrossRef
  • Graves’ disease and the risk of Parkinson’s disease: a Korean population-based study
    Yoon Young Cho, Bongseong Kim, Dong Wook Shin, Jinyoung Youn, Ji Oh Mok, Chul-Hee Kim, Sun Wook Kim, Jae Hoon Chung, Kyungdo Han, Tae Hyuk Kim
    Brain Communications.2022;[Epub]     CrossRef
  • Graves’ Disease and the Risk of End-Stage Renal Disease: A Korean Population-Based Study
    Yoon Young Cho, Bongseong Kim, Dong Wook Shin, Hye Ryoun Jang, Bo-Yeon Kim, Chan-Hee Jung, Jae Hyeon Kim, Sun Wook Kim, Jae Hoon Chung, Kyungdo Han, Tae Hyuk Kim
    Endocrinology and Metabolism.2022; 37(2): 281.     CrossRef
  • Evaluation and Management of Bone Health in Patients with Thyroid Diseases: a Position Statement from the Korean Thyroid Association
    A Ram Hong, Hwa Young Ahn, Bu Kyung Kim, Seong Hee Ahn, So Young Park, Min-Hee Kim, Jeongmin Lee, Sun Wook Cho, Ho-Cheol Kang
    International Journal of Thyroidology.2022; 15(1): 1.     CrossRef
  • Patient Population and Test Utilization for Thyroid Function in Local Clinics and Hospitals in Korea
    Rihwa Choi, Sang Gon Lee, Eun Hee Lee
    Diagnostics.2022; 12(7): 1638.     CrossRef
  • 2021 Asia-Pacific Graves’ Disease Consortium Survey of Clinical Practice Patterns in the Management of Graves’ Disease
    Rajeev Parameswaran, Mechteld Christine de Jong, James Lee Wai Kit, Kathleen Sek, Tran Quang Nam, Tran Viet Thang, Nguyen Thy Khue, Than Than Aye, Phone Myint Tun, Timothy Cole, Julie A. Miller, Michael Villa, Benjapa Khiewvan, Sirinart Sirinvaravong, Yon
    Endocrine.2022; 79(1): 135.     CrossRef
  • Graves’ disease, its treatments, and the risk of atrial fibrillation: A Korean population-based study
    Yoon Young Cho, Bongseong Kim, Dughyun Choi, Chul-Hee Kim, Dong Wook Shin, Jee Soo Kim, Seung-Jung Park, Sun Wook Kim, Jae Hoon Chung, Kyungdo Han, Tae Hyuk Kim
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Forty Years Together, New Leap Forward! The 40th Anniversary of the Korean Endocrine Society
    Jong Chul Won, Ki-Hyun Baek
    Endocrinology and Metabolism.2022; 37(6): 851.     CrossRef
  • Evaluation of the role of thyroid scintigraphy in the differential diagnosis of thyrotoxicosis
    Carolina M. Perdomo, Marta García‐Goñi, Lidia Sancho, José J. Paricio, María D. Lozano, Magdalena de la Higuera, María Currás, Javier Arbizu, Juan C. Galofré
    Clinical Endocrinology.2021; 94(3): 466.     CrossRef
  • Treatment of patients with Graves’ disease in Sweden compared to international surveys of an ‘index patient’
    Gabriel Sjölin, Kristina Byström, Mats Holmberg, Ove Törring, Selwan Khamisi, Jan Calissendorff, Mikael Lantz, Bengt Hallengren, Helena Filipsson Nyström, Tereza Planck, Göran Wallin
    Endocrinology, Diabetes & Metabolism.2021;[Epub]     CrossRef
  • Secular Trends in Ablation Therapy for Graves’ Disease: An Analysis of a 15-Year Experience at a Tertiary Hospital in South Korea
    Min Joo Kim, Ye An Kim, Sun Wook Cho, Su-jin Kim, Kyu Eun Lee, Young Joo Park, Do Joon Park, Bo Youn Cho
    Journal of Clinical Medicine.2021; 10(8): 1629.     CrossRef
  • Long-Term Antithyroid Drug Treatment of Graves’ Disease in Children and Adolescents: A 20-Year Single-Center Experience
    Ari Song, Su Jin Kim, Min-Sun Kim, Jiyeon Kim, Insung Kim, Ga Young Bae, Eunseop Seo, Young Seok Cho, Joon Young Choi, Sung Yoon Cho, Dong-Kyu Jin
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Association of Polygenetic Risk Scores Related to Immunity and Inflammation with Hyperthyroidism Risk and Interactions between the Polygenetic Scores and Dietary Factors in a Large Cohort
    Mi Young Song, Sunmin Park, Anjali Mishra
    Journal of Thyroid Research.2021; 2021: 1.     CrossRef
  • Treatment Modality and Risk of Heart Failure in Patients With Long-Standing Graves’ Disease: A Nationwide Population-Based Cohort Study
    Eyun Song, Mina Kim, Sojeong Park, Min Jeong Park, Jung A. Kim, Eun Roh, Ji Hee Yu, Nam Hoon Kim, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Risk of Diabetes in Patients with Long-Standing Graves’ Disease: A Longitudinal Study
    Eyun Song, Min Ji Koo, Eunjin Noh, Soon Young Hwang, Min Jeong Park, Jung A Kim, Eun Roh, Kyung Mook Choi, Sei Hyun Baik, Geum Joon Cho, Hye Jin Yoo
    Endocrinology and Metabolism.2021; 36(6): 1277.     CrossRef
  • Diabetes and Hyperthyroidism: Is There a Causal Link?
    Sang Yong Kim
    Endocrinology and Metabolism.2021; 36(6): 1175.     CrossRef
  • Incidence and Mortality of Myocardial Infarction and Stroke in Patients with Hyperthyroidism: A Nationwide Cohort Study in Korea
    Hyun Jung Kim, Taeuk Kang, Min Ji Kang, Hyeong Sik Ahn, Seo Young Sohn
    Thyroid.2020; 30(7): 955.     CrossRef
  • Diagnosis and Management of Graves’ Disease in Thailand: A Survey of Current Practice
    Chutintorn Sriphrapradang
    Journal of Thyroid Research.2020; 2020: 1.     CrossRef
  • The success rate of radioactive iodine therapy for Graves’ disease in iodine-replete area and affecting factors: a single-center study
    Hyunju Park, Hye In Kim, Jun Park, So Young Park, Tae Hyuk Kim, Jae Hoon Chung, Joon Young Choi, Sun Wook Kim
    Nuclear Medicine Communications.2020; 41(3): 212.     CrossRef
  • Tirotoksikoz nedenli erektil disfonksiyon üzerine sildenafil etkisinin histopatolojik olarak değerlendirilmesi
    Murat ÖZDEMİR, Canberk TOMRUK, Gürkan YİĞİTTÜRK, Varlık EROL, Emel Öykü ÇETİN, Ilgın YILDIRIM ŞİMŞİR, Çiğdem YENİSEY, Yiğit UYANIKGİL, Adnan ŞİMŞİR, Özer MAKAY
    Ege Tıp Dergisi.2020; 59(3): 215.     CrossRef
  • The Management of Thyroid Disease in COVID-19 Pandemic
    Won Sang Yoo, Hyun-Kyung Chung
    International Journal of Thyroidology.2020; 13(2): 65.     CrossRef
  • Is Hyperthyroidism Diagnosed and Treated Appropriately in the United States?
    Ammar Asban, Sophie Dream, Brenessa Lindeman
    Advances in Surgery.2019; 53: 117.     CrossRef
  • Long-term remission following antithyroid drug withdrawal in patients with Graves’ hyperthyroidism: parameters with prognostic value
    Ricardo V. García-Mayor, Paula Álvarez-Vázquez, Enrique Fluiters, Diana Valverde, Amalia Andrade
    Endocrine.2019; 63(2): 316.     CrossRef
  • Safety of long-term antithyroid drug treatment? A systematic review
    F. Azizi, R. Malboosbaf
    Journal of Endocrinological Investigation.2019; 42(11): 1273.     CrossRef
  • Changes in Thyroid Peroxidase and Thyroglobulin Antibodies Might Be Associated with Graves' Disease Relapse after Antithyroid Drug Therapy
    Yun Mi Choi, Mi Kyung Kwak, Sang Mo Hong, Eun-Gyoung Hong
    Endocrinology and Metabolism.2019; 34(3): 268.     CrossRef
  • Prevalence and Annual Incidence of Thyroid Disease in Korea from 2006 to 2015: A Nationwide Population-Based Cohort Study
    Hyemi Kwon, Jin-hyung Jung, Kyung-Do Han, Yong-Gyu Park, Jung-Hwan Cho, Da Young Lee, Ji Min Han, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
    Endocrinology and Metabolism.2018; 33(2): 260.     CrossRef
  • An update in the treatment preference for hyperthyroidism
    Obin Kwon
    Nature Reviews Endocrinology.2018; 14(7): 438.     CrossRef
  • Clinical Feasibility of Monitoring Resting Heart Rate Using a Wearable Activity Tracker in Patients With Thyrotoxicosis: Prospective Longitudinal Observational Study
    Jie-Eun Lee, Dong Hwa Lee, Tae Jung Oh, Kyoung Min Kim, Sung Hee Choi, Soo Lim, Young Joo Park, Do Joon Park, Hak Chul Jang, Jae Hoon Moon
    JMIR mHealth and uHealth.2018; 6(7): e159.     CrossRef
  • Graves' Disease Patients with Large Goiters Respond Best to Radioactive Iodine Doses of at Least 15 mCi: a Sonographic Volumetric Study
    Yun Ah Jeong, Jee Hee Yoon, Hee Kyung Kim, Ho-Cheol Kang
    International Journal of Thyroidology.2018; 11(2): 137.     CrossRef
  • Chylothorax Associated with Substernal Goiter in Graves’ Disease Treated with Radioactive Iodine
    Seo Young Oh, Bo Hyun Kim, Do Young Kim, Kyu Min Lee, Min Jin Lee, Sung Su Kim, Jong Ho Kim, Yun Kyung Jeon, Sang Soo Kim, Yong Ki Kim, In Joo Kim
    International Journal of Endocrinology and Metabolism.2017;[Epub]     CrossRef
  • Vitiligo and overt thyroid diseases: A nationwide population-based study in Korea
    Jung Min Bae, June Hyunkyung Lee, Jae Seung Yun, Byeol Han, Tae Young Han
    Journal of the American Academy of Dermatology.2017; 76(5): 871.     CrossRef
  • Increased risk of thyroid diseases in patients with systemic lupus erythematosus: A nationwide population-based Study in Korea
    Jae-Seung Yun, Jung Min Bae, Ki-Jo Kim, Yu Seok Jung, Gyong Moon Kim, Hyung-Rae Kim, Jun-Seok Lee, Seung-Hyun Ko, Seon-Ah Cha, Yu-Bae Ahn, Ludmila Prokunina-Olsson
    PLOS ONE.2017; 12(6): e0179088.     CrossRef
  • The Second Antithyroid Drug Treatment Is Effective in Relapsed Graves' Disease Patients: A Median 11-Year Follow-Up Study
    Ye An Kim, Sun Wook Cho, Hoon Sung Choi, Shinje Moon, Jae Hoon Moon, Kyung Won Kim, Do Joon Park, Ka Hee Yi, Young Joo Park, Bo Youn Cho
    Thyroid.2017; 27(4): 491.     CrossRef
  • Free Thyroxine, Anti-Thyroid Stimulating Hormone Receptor Antibody Titers, and Absence of Goiter Were Associated with Responsiveness to Methimazole in Patients with New Onset Graves' Disease
    Hoon Sung Choi, Won Sang Yoo
    Endocrinology and Metabolism.2017; 32(2): 281.     CrossRef
  • Long-Term Antithyroid Drug Treatment: A Systematic Review and Meta-Analysis
    Fereidoun Azizi, Ramin Malboosbaf
    Thyroid.2017; 27(10): 1223.     CrossRef
  • The Recurrence Rate of Graves' Disease among Patients with Subclinical Thyrotoxicosis after Initial Remission with Antithyroid Agents
    Myoung Sook Shim, Soo Min Nam, Jin Sae Yoo, Hae Kyung Kim, Sang Jun Lee, Mi Young Lee
    International Journal of Thyroidology.2017; 10(2): 77.     CrossRef
  • Serum 25-hydroxyvitamin D might be an independent prognostic factor for Graves disease recurrence
    Hwa Young Ahn, Yun Jae Chung, Bo Youn Cho
    Medicine.2017; 96(31): e7700.     CrossRef
  • Recent Advances in Autoimmune Thyroid Diseases
    Won Sang Yoo, Hyun Kyung Chung
    Endocrinology and Metabolism.2016; 31(3): 379.     CrossRef
  • Usefulness of Measuring Thyroid Stimulating Antibody at the Time of Antithyroid Drug Withdrawal for Predicting Relapse of Graves Disease
    Hyemi Kwon, Won Gu Kim, Eun Kyung Jang, Mijin Kim, Suyeon Park, Min Ji Jeon, Tae Yong Kim, Jin-Sook Ryu, Young Kee Shong, Won Bae Kim
    Endocrinology and Metabolism.2016; 31(2): 300.     CrossRef
  • Hyperthyroidism
    Simone De Leo, Sun Y Lee, Lewis E Braverman
    The Lancet.2016; 388(10047): 906.     CrossRef
  • Differentiating Graves' disease from subacute thyroiditis using ratio of serum free triiodothyronine to free thyroxine
    Chutintorn Sriphrapradang, Adikan Bhasipol
    Annals of Medicine and Surgery.2016; 10: 69.     CrossRef
  • Management of hyperthyroid patients in dental emergencies: a case report
    Kyung-Jin Lee, Wonse Park, Nan-Sim Pang, Jin-Hyung Cho, Kee-Deog Kim, Bock Young Jung, Eun-Jung Kwak
    Journal of Dental Anesthesia and Pain Medicine.2016; 16(2): 147.     CrossRef
  • The Presence of Thyroid-Stimulation Blocking Antibody Prevents High Bone Turnover in Untreated Premenopausal Patients with Graves’ Disease
    Sun Wook Cho, Jae Hyun Bae, Gyeong Woon Noh, Ye An Kim, Min Kyong Moon, Kyoung Un Park, Junghan Song, Ka Hee Yi, Do Joon Park, June-Key Chung, Bo Youn Cho, Young Joo Park, Jung-Eun Kim
    PLOS ONE.2015; 10(12): e0144599.     CrossRef
  • Refractory Graves' Disease Successfully Cured by Adjunctive Cholestyramine and Subsequent Total Thyroidectomy
    Yeoree Yang, Seawon Hwang, Minji Kim, Yejee Lim, Min-Hee Kim, Sohee Lee, Dong-Jun Lim, Moo-Il Kang, Bong-Yun Cha
    Endocrinology and Metabolism.2015; 30(4): 620.     CrossRef
  • Improved quality of life in hyperthyroidism patients after surgery
    Branka Bukvic, Vladan Zivaljevic, Sandra Sipetic, Aleksandar Diklic, Katarina Tausanovic, Dragos Stojanovic, Dejan Stevanovic, Ivan Paunovic
    Journal of Surgical Research.2015; 193(2): 724.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
Close layer
Obesity and Metabolism
Recent Advances in Diagnostic Strategies for Diabetic Peripheral Neuropathy
Jong Chul Won, Tae Sun Park
Endocrinol Metab. 2016;31(2):230-238.   Published online May 27, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.2.230
  • 7,465 View
  • 128 Download
  • 51 Web of Science
  • 53 Crossref
AbstractAbstract PDFPubReader   

Diabetes is an increasing epidemic in Korea, and associated diabetic peripheral neuropathy (DPN) is its most common and disabling complication. DPN has an insidious onset and heterogeneous clinical manifestations, making it difficult to detect high-risk patients of DPN. Early diagnosis is recommended and is the key factor for a better prognosis and preventing diabetic foot ulcers, amputation, or disability. However, diagnostic tests for DPN are not clearly established because of the various pathophysiology developing from the nerve injury to clinical manifestations, differences in mechanisms according to the type of diabetes, comorbidities, and the unclear natural history of DPN. Therefore, DPN remains a challenge for physicians to screen, diagnose, follow up, and evaluate for treatment response. In this review, diagnosing DPN using various methods to assess clinical symptoms and/or signs, sensorineural impairment, and nerve conduction studies will be discussed. Clinicians should rely on established modalities and utilize current available testing as complementary to specific clinical situations.

Citations

Citations to this article as recorded by  
  • The Relationship Between UA/HDL and Diabetic Peripheral Neuropathy: A Cross-Sectional Analysis
    Ruoxi Zhen, Shuqi Wang, Shuchun Chen
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 969.     CrossRef
  • Role of Regenerative Therapeutics in Diabetic Peripheral Neuropathy: Current Advances and Future Prospects
    Sanjay Sharma, Ravi Velamoor Rangarajan
    European Journal of Medical and Health Sciences.2024; 6(2): 1.     CrossRef
  • DSPNet: A Self-ONN Model for Robust DSPN Diagnosis From Temperature Maps
    Amith Khandakar, Muhammad E. H. Chowdhury, Mamun Bin Ibne Reaz, Serkan Kiranyaz, Anwarul Hasan, Tawsifur Rahman, Sawal Hamid Md. Ali, Mohd Ibrahim bin Shapiai @ Abd. Razak, Ahmad Ashrif A. Bakar, Kanchon Kanti Podder, Moajjem Hossain Chowdhury, Md. Ahasan
    IEEE Sensors Journal.2023; 23(5): 5370.     CrossRef
  • A Machine Learning-Based Severity Prediction Tool for the Michigan Neuropathy Screening Instrument
    Fahmida Haque, Mamun B. I. Reaz, Muhammad E. H. Chowdhury, Mohd Ibrahim bin Shapiai, Rayaz A. Malik, Mohammed Alhatou, Syoji Kobashi, Iffat Ara, Sawal H. M. Ali, Ahmad A. A. Bakar, Mohammad Arif Sobhan Bhuiyan
    Diagnostics.2023; 13(2): 264.     CrossRef
  • Screening for diabetic peripheral neuropathy in resource-limited settings
    Ken Munene Nkonge, Dennis Karani Nkonge, Teresa Njeri Nkonge
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Assessment of Lumbosacral Nerve Roots in Patients with Type 2 Diabetic Peripheral Neuropathy Using Diffusion Tensor Imaging
    He Chen, Yanyan Xu, Wei Wang, Ruifen Deng, Zhaoqing Li, Sheng Xie, Jinsong Jiao
    Brain Sciences.2023; 13(5): 828.     CrossRef
  • Evidence of impaired H-reflex and H-reflex rate-dependent depression in diabetes, prediabetes and obesity: a mini-review
    Rebeca Kababie-Ameo, Gabriela Gutiérrez-Salmeán, Carlos A. Cuellar
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • The effect of polyneuropathy severity on nerve conduction and pain syndrome in patients with type 2 diabetes
    A.Ya. Sabovchyk, M.M. Oros
    INTERNATIONAL NEUROLOGICAL JOURNAL.2023; 19(6): 161.     CrossRef
  • Effects of Neural Mobilization in Diabetic Peripheral Neuropathy: A Scoping Review
    Muhammad Azharuddin, Sarah Parveen, Majumi M. Noohu
    Journal of Chiropractic Medicine.2023; 22(4): 313.     CrossRef
  • Effect of massage, passive neural mobilization and transcutaneous electrical nerve stimulation on magnetic resonance diffusion tensor imaging (MR-DTI) of the tibial nerve in a patient with type 2 diabetes mellitus induced neuropathy: a case report
    Goyal Manu, Mittal Amit, Samuel Asir John
    Physiotherapy Theory and Practice.2022; 38(13): 3273.     CrossRef
  • Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy
    WeiZheng So, NatalieShi Qi Wong, HongChang Tan, MollyTzu Yu Lin, IsabelleXin Yu Lee, JodhbirS Mehta, Yu-Chi Liu
    Neural Regeneration Research.2022; 17(10): 2172.     CrossRef
  • SUDOSCAN in Combination with the Michigan Neuropathy Screening Instrument Is an Effective Tool for Screening Diabetic Peripheral Neuropathy
    Tae Jung Oh, Yoojung Song, Hak Chul Jang, Sung Hee Choi
    Diabetes & Metabolism Journal.2022; 46(2): 319.     CrossRef
  • Performance Analysis of Conventional Machine Learning Algorithms for Diabetic Sensorimotor Polyneuropathy Severity Classification Using Nerve Conduction Studies
    Fahmida Haque, Mamun B. I. Reaz, Muhammad E. H. Chowdhury, Serkan Kiranyaz, Sawal H. M. Ali, Mohammed Alhatou, Rumana Habib, Ahmad A. A. Bakar, Norhana Arsad, Geetika Srivastava, Paolo Crippa
    Computational Intelligence and Neuroscience.2022; 2022: 1.     CrossRef
  • The Presence of Clonal Hematopoiesis Is Negatively Associated with Diabetic Peripheral Neuropathy in Type 2 Diabetes
    Tae Jung Oh, Han Song, Youngil Koh, Sung Hee Choi
    Endocrinology and Metabolism.2022; 37(2): 243.     CrossRef
  • Advances in traditional Chinese medicine as adjuvant therapy for diabetic foot
    Fa-Shun Liu, Yue Li, Xian-Shan Guo, Rui-Chen Liu, Hong-Ya Zhang, Zhen Li
    World Journal of Diabetes.2022; 13(10): 851.     CrossRef
  • Magnitude of diabetic peripheral neuropathy in Saudi Arabia: a systematic review and meta-analysis
    Lukman Femi Owolabi, Mushabab Alghamdi, Bappa Adamu, Magaji Garba Taura, Abubakar Jibo, Mohammed Almansour, Saeed Naseer Alaklabi, Mohammed Ali Alghamdi, Yousef Ayesh Alotaibi, Isa Adamu Imam, Reda Abdelrazak, Ahmad Rafaat, Muktar Hassan Aliyu
    BMC Endocrine Disorders.2022;[Epub]     CrossRef
  • Artificial Intelligence Methodologies Applied to Technologies for Screening, Diagnosis and Care of the Diabetic Foot: A Narrative Review
    Gaetano Chemello, Benedetta Salvatori, Micaela Morettini, Andrea Tura
    Biosensors.2022; 12(11): 985.     CrossRef
  • Diabetic foot ulcer: Challenges and future
    Li Yang, Gui-Chuan Rong, Qi-Nan Wu
    World Journal of Diabetes.2022; 13(12): 1014.     CrossRef
  • A review of the current evidence on the sensitivity and specificity of the Ipswich touch test for the screening of loss of protective sensation in patients with diabetes mellitus
    Arnold Hu, Beatrice Koh, Melissa- Raye Teo
    Diabetology International.2021; 12(2): 145.     CrossRef
  • Prevalence of diabetic peripheral neuropathy in patients with type 2 diabetes mellitus at a tertiary referral centre in Singapore
    Arnold Hu Hanquan, Melissa-Raye Teo Li Wen
    Proceedings of Singapore Healthcare.2021; 30(4): 265.     CrossRef
  • Performance Analysis of Conventional Machine Learning Algorithms for Diabetic Sensorimotor Polyneuropathy Severity Classification
    Fahmida Haque, Mamun Bin Ibne Reaz, Muhammad Enamul Hoque Chowdhury, Geetika Srivastava, Sawal Hamid Md Ali, Ahmad Ashrif A. Bakar, Mohammad Arif Sobhan Bhuiyan
    Diagnostics.2021; 11(5): 801.     CrossRef
  • Thai version of the Questionnaire for Diabetes-Related Foot Disease (Thai Q-DFD): validity and reliability
    Rapeepun Thungtak, Jirabhorn Wannapakhe, Saitida Lapanantasin
    Heliyon.2021; 7(8): e07832.     CrossRef
  • A nomogram-based diabetic sensorimotor polyneuropathy severity prediction using Michigan neuropathy screening instrumentations
    Fahmida Haque, Mamun Bin Ibne Reaz, Muhammad E.H. Chowdhury, Sawal Hamid Md Ali, Ahmad Ashrif A Bakar, Tawsifur Rahman, Syoji Kobashi, Chitra A. Dhawale, Mohammad Arif Sobhan Bhuiyan
    Computers in Biology and Medicine.2021; 139: 104954.     CrossRef
  • Correlation Between Hemoglobin Glycosylation Index and Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus
    Zelin Li, Yuan Gao, Yujiao Jia, Shuchun Chen
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 4757.     CrossRef
  • Liver fibrosis indices are related to diabetic peripheral neuropathy in individuals with type 2 diabetes
    Kyuho Kim, Tae Jung Oh, Hyen Chung Cho, Yun Kyung Lee, Chang Ho Ahn, Bo Kyung Koo, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang
    Scientific Reports.2021;[Epub]     CrossRef
  • Standard clinical screening tests, sural radial amplitude ratio and f wave latency compared to conventional nerve conduction studies in the assessment of sensorimotor polyneuropathy in patients with type 2 diabetes mellitus
    Saraswathi Ramanathan, Raji Thomas, AsemRangita Chanu, Dukhabandu Naik, Felix Jebasingh, Ajit Sivadasan, Nihal Thomas
    Indian Journal of Endocrinology and Metabolism.2021; 25(6): 509.     CrossRef
  • IFN‐γ/mTORC1 decreased Rab11 in Schwann cells of diabetic peripheral neuropathy, inhibiting cell proliferation via GLUT1 downregulation
    Wei Du, Song Zhao, Fan Gao, Mengyu Wei, Jiahui An, Keqi Jia, Fan Li, Lin Zhu, Jun Hao
    Journal of Cellular Physiology.2020; 235(7-8): 5764.     CrossRef
  • Diagnosis and treatment of the early stages of diabetic polyneuropathy
    V. N. Khramilin, A. N. Zavyalov, I. Yu. Demidova
    Meditsinskiy sovet = Medical Council.2020; (7): 56.     CrossRef
  • Diabetic Peripheral Neuropathy: Is it Underdiagnosed?
    Rizaldy T. Pinzon, M. Kes, Rosa De Lima R. Sa
    Asian Journal of Biological Sciences.2020; 13(2): 168.     CrossRef
  • The Effects of Tocotrienol-Rich Vitamin E (Tocovid) on Diabetic Neuropathy: A Phase II Randomized Controlled Trial
    Yeek Tat Ng, Sonia Chew Wen Phang, Gerald Chen Jie Tan, En Yng Ng, Nevein Philip Botross Henien, Uma Devi M. Palanisamy, Badariah Ahmad, Khalid Abdul Kadir
    Nutrients.2020; 12(5): 1522.     CrossRef
  • Prevalence of diabetic peripheral neuropathy in Africa: a systematic review and meta-analysis
    Wondimeneh Shibabaw Shiferaw, Tadesse Yirga Akalu, Yeshamble Work, Yared Asmare Aynalem
    BMC Endocrine Disorders.2020;[Epub]     CrossRef
  • Choosing a Vibratory Test to Pair With Semmes Weinstein Monofilament Testing for Evaluating Lower Extremity Sensation in Patients With Diabetes: A Comparison of Three Vibratory Methodologies
    Bryan Raymond, James Steriovski, KaNesha Gillyard, Chalen Yang, Stephanie C. Wu, Ryan T. Crews
    Journal of Diabetes Science and Technology.2020; 14(1): 8.     CrossRef
  • Is it possible to substitute the monofilament test for the Ipswich Touch Test in screening for peripheral diabetic neuropathy?
    Luz Marina Alfonso Dutra, Mirian Conceição Moura, Flaviene Alves do Prado, Giselle De Oliveira Lima, Manuela Costa Melo, Rubens Nelson Morato Fernandez, Maria Rita Carvalho Garbi Novaes
    Diabetology & Metabolic Syndrome.2020;[Epub]     CrossRef
  • Correlation Between Thioredoxin-Interacting Protein and Nerve Conduction Velocity in Patients With Type 2 Diabetes Mellitus
    Yuan Gao, Shuchun Chen, Minmin Peng, Zi Wang, Luping Ren, Shumin Mu, Meiling Zheng
    Frontiers in Neurology.2020;[Epub]     CrossRef
  • Performance analysis of noninvasive electrophysiological methods for the assessment of diabetic sensorimotor polyneuropathy in clinical research: a systematic review and meta-analysis with trial sequential analysis
    Fahmida Haque, Mamun Bin Ibne Reaz, Sawal Hamid Md Ali, Norhana Arsad, Muhammad Enamul Hoque Chowdhury
    Scientific Reports.2020;[Epub]     CrossRef
  • The impact of demographic and clinical characteristics on diabetic painful neuropathy
    António Assunção, Dina Campos, Rui Marques, Inês Cunha, Patrícia Santos, Adriana Martins, Ana Sofia Gonçalves, Ana Rebelo, Carolina Lima, César Matos, Ana Cristina Prata, José Tiago Teixeira, Luís Duarte, Mariana Belo, Patrícia Figueiredo, Tiago Letras Ro
    Romanian Journal of Internal Medicine.2020; 58(1): 13.     CrossRef
  • Nanotechnology in peripheral nerve repair and reconstruction
    Cristiana R. Carvalho, Joana Silva-Correia, Joaquim M. Oliveira, Rui L. Reis
    Advanced Drug Delivery Reviews.2019; 148: 308.     CrossRef
  • The risk factors for diabetic peripheral neuropathy: A meta-analysis
    Xiuxiu Liu, Yuyan Xu, Miaomiao An, Qibing Zeng, Antonio Palazón-Bru
    PLOS ONE.2019; 14(2): e0212574.     CrossRef
  • Association between deterioration in muscle strength and peripheral neuropathy in people with diabetes
    Tae Jung Oh, Sunyoung Kang, Jie-Eun Lee, Jae Hoon Moon, Sung Hee Choi, Soo Lim, Hak Chul Jang
    Journal of Diabetes and its Complications.2019; 33(8): 598.     CrossRef
  • Characterizing distal peripheral neuropathy in type 2 diabetes mellitus in a semi-urban community setting in Peru
    Meera F Iyengar, Antonio Bernabe-Ortiz
    Journal of Global Health Reports.2019;[Epub]     CrossRef
  • A study protocol on nerve mobilization induced diffusion tensor imaging values in posterior tibial nerve in healthy controls and in patients with diabetic neuropathy-multigroup pretest posttest design
    Manu Goyal, Vandana Esht, Amit Mittal
    Contemporary Clinical Trials Communications.2019; 16: 100451.     CrossRef
  • The Akt/mTOR cascade mediates high glucose-induced reductions in BDNF via DNMT1 in Schwann cells in diabetic peripheral neuropathy
    Cui-Hong Zhang, Xin Lv, Wei Du, Mei-Juan Cheng, Ya-Ping Liu, Lin Zhu, Jun Hao
    Experimental Cell Research.2019; 383(1): 111502.     CrossRef
  • Transcriptome analysis of dorsal root ganglia's diabetic neuropathy reveals mechanisms involved in pain and regeneration
    Maria Carolina Pedro Athie, Andre Schwambach Vieira, Juliana Maia Teixeira, Gilson Gonçalves dos Santos, Elayne Vieira Dias, Claudia Herrera Tambeli, Cesar Renato Sartori, Carlos A. Parada
    Life Sciences.2018; 205: 54.     CrossRef
  • Diagnosis and Management of Diabetic Peripheral Neuropathy
    Seong-Su Moon
    The Journal of Korean Diabetes.2018; 19(3): 153.     CrossRef
  • Efficacy of epalrestat plus α-lipoic acid combination therapy versus monotherapy in patients with diabetic peripheral neuropathy: a meta-analysis of 20 randomized controlled trials
    Ming Zhao, Jia-Yi Chen, Yu-Dong Chu, Ya-Bin Zhu, Lin Luo, Shi-Zhong Bu
    Neural Regeneration Research.2018; 13(6): 1087.     CrossRef
  • Interactions between and Shared Molecular Mechanisms of Diabetic Peripheral Neuropathy and Obstructive Sleep Apnea in Type 2 Diabetes Patients
    Hong Shen, Junrong Zhao, Ying Liu, Guangdong Sun
    Journal of Diabetes Research.2018; 2018: 1.     CrossRef
  • Evaluation of the healthy median nerve elasticity
    Bihui Zhu, Feng Yan, Ying He, Liyun Wang, Xi Xiang, Yuanjiao Tang, Yujia Yang, Li Qiu
    Medicine.2018; 97(43): e12956.     CrossRef
  • Association between thermal threshold abnormalities and peripheral artery disease in patients with type 2 diabetes
    Yi-Jing Sheen, Tsai-Chung Li, Jiann-Liang Lin, Wen-Chen Tsai, Chuen-Der Kao, Cho-Tsan Bau, Wayne H.-H. Sheu
    Medicine.2018; 97(51): e13803.     CrossRef
  • Neurogenic Pain Disorder in the Foot and Ankle: Peripheral Neuropathy
    Hak Jun Kim, Young Hwan Park, Soo Hyun Kim
    Journal of the Korean Orthopaedic Association.2017; 52(4): 305.     CrossRef
  • Diabetes-Related Microvascular Complications: What Every Nurse Practitioner Needs to Know
    Eileen Egan
    The Journal for Nurse Practitioners.2017; 13(3): 192.     CrossRef
  • Comparison of electrochemical skin conductance and vibration perception threshold measurement in the detection of early diabetic neuropathy
    Amit Goel, Channabasappa Shivaprasad, Anish Kolly, Vijaya Sarathi H. A., Sridevi Atluri, Rayaz Ahmed Malik
    PLOS ONE.2017; 12(9): e0183973.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
  • Nailfold capillary abnormalities are associated with type 2 diabetes progression and correlated with peripheral neuropathy
    Po-Chi Hsu, Pei-Yung Liao, Hen-Hong Chang, John Y. Chiang, Yu-Chuen Huang, Lun-Chien Lo
    Medicine.2016; 95(52): e5714.     CrossRef
Close layer
Obesity and Metabolism
The Diabetes Epidemic in Korea
Junghyun Noh
Endocrinol Metab. 2016;31(3):349-353.   Published online August 26, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.349
  • 6,143 View
  • 49 Download
  • 49 Web of Science
  • 53 Crossref
AbstractAbstract PDFPubReader   

Diabetes is one of the foremost public health issues worldwide that can lead to complications in many organ systems, and has become a significant cause of morbidity and mortality in Korea. According to data from the National Health Insurance Service (NHIS), about 2.7 million Koreans (8.0%) aged 30 years or older had type 2 diabetes mellitus (T2DM) in 2013. The prevalence of T2DM increased with age and rose from 5.6% in 2006 to 8.0% in 2013. Using data based on The Health Screening Service of the NHIS, 25% of Korean adults were reported to have prediabetes in 2013. The prevalence of an impaired fasting glucose tended to increase over time from 21.5% in 2006 to 25.0% in 2013. Even though nationwide health screening has been regularly conducted as a public service, the proportion of undiagnosed cases of diabetes was still reported to be on the higher side in the latest study. Based on the results of these epidemic studies, further actions will be needed to effectively implement lifestyle changes on a social level and increase measures for the early detection of diabetes to stem the tide of the epidemic.

Citations

Citations to this article as recorded by  
  • A Nationwide Population‐Based Study for the Recurrence and Comorbidities in Sudden Sensorineural Hearing Loss
    Hye Yeon Ko, Hae Jeong Nam, Min Hee Kim
    The Laryngoscope.2024; 134(3): 1417.     CrossRef
  • Real-World Outcomes of Individualized Targeted Therapy with Insulin Glargine 300 Units/mL in Insulin-Naïve Korean People with Type 2 Diabetes: TOBE Study
    Eun-Gyoung Hong, Kyung-Wan Min, Jung Soo Lim, Kyu-Jeung Ahn, Chul Woo Ahn, Jae-Myung Yu, Hye Soon Kim, Hyun Jin Kim, Won Kim, Dong Han Kim, Hak Chul Jang
    Advances in Therapy.2024;[Epub]     CrossRef
  • Cancer risk according to fasting blood glucose trajectories: a population-based cohort study
    Thi Minh Thu Khong, Thi Tra Bui, Hee-Yeon Kang, Jinhee Lee, Eunjung Park, Jin-Kyoung Oh
    BMJ Open Diabetes Research & Care.2024; 12(1): e003696.     CrossRef
  • Nomenclature Dilemma of Metabolic Associated Fatty Liver Disease (MAFLD): Considerable Proportions of MAFLD Are Metabolic Healthy
    Huiyul Park, Eileen L. Yoon, Mimi Kim, Seon Cho, Eun-Hee Nah, Dae Won Jun
    Clinical Gastroenterology and Hepatology.2023; 21(4): 1041.     CrossRef
  • Efficacy of Polydeoxyribonucleotide in Promoting the Healing of Diabetic Wounds in a Murine Model of Streptozotocin-Induced Diabetes: A Pilot Experiment
    Jiyoung Yun, SaeGwang Park, Ha Young Park, Kyung Ah Lee
    International Journal of Molecular Sciences.2023; 24(3): 1932.     CrossRef
  • Influence of Fasting Glucose Level on Gastric Cancer Incidence in a Prospective Cohort Study
    Tao Thi Tran, Jeonghee Lee, Madhawa Gunathilake, Hyunsoon Cho, Jeongseon Kim
    Cancer Epidemiology, Biomarkers & Prevention.2022; 31(1): 254.     CrossRef
  • A Comparative analysis of type 2 diabetes management quality indicators in cancer survivors
    Eun J. Ko, Su J. Lee
    Asia-Pacific Journal of Oncology Nursing.2022; 9(11): 100116.     CrossRef
  • Comparative Effects of Sodium-Glucose Cotransporter 2 Inhibitor and Thiazolidinedione Treatment on Risk of Stroke among Patients with Type 2 Diabetes Mellitus
    Seung Eun Lee, Hyewon Nam, Han Seok Choi, Hoseob Kim, Dae-Sung Kyoung, Kyoung-Ah Kim
    Diabetes & Metabolism Journal.2022; 46(4): 567.     CrossRef
  • Prevalence and diagnosis experience of osteoporosis in postmenopausal women over 50: Focusing on socioeconomic factors
    Min Hyeok Choi, Ji Hee Yang, Jae Seung Seo, Yoon-ji Kim, Suk-Woong Kang, Jose M. Moran
    PLOS ONE.2021; 16(3): e0248020.     CrossRef
  • Effect of Teneligliptin versus Sulfonylurea on Major Adverse Cardiovascular Outcomes in People with Type 2 Diabetes Mellitus: A Real-World Study in Korea
    Da Hea Seo, Kyoung Hwa Ha, So Hun Kim, Dae Jung Kim
    Endocrinology and Metabolism.2021; 36(1): 70.     CrossRef
  • A nationwide study of patients with monoclonal gammopathy of undetermined significance with a 10-year follow-up in South Korea
    Ka-Won Kang, Ji Eun Song, Byung-Hyun Lee, Min Ji Jeon, Eun Sang Yu, Dae Sik Kim, Se Ryeon Lee, Hwa Jung Sung, Chul Won Choi, Yong Park, Byung Soo Kim
    Scientific Reports.2021;[Epub]     CrossRef
  • Fibrosis Burden of Missed and Added Populations According to the New Definition of Metabolic Dysfunction-Associated Fatty Liver
    Huiyul Park, Eileen L. Yoon, Mimi Kim, Jung-Hwan Kim, Seon Cho, Dae Won Jun, Eun-Hee Nah
    Journal of Clinical Medicine.2021; 10(19): 4625.     CrossRef
  • The Effects of Glucose Lowering Agents on the Secondary Prevention of Coronary Artery Disease in Patients with Type 2 Diabetes
    Inha Jung, Hyemi Kwon, Se Eun Park, Kyung-Do Han, Yong-Gyu Park, Eun-Jung Rhee, Won-Young Lee
    Endocrinology and Metabolism.2021; 36(5): 977.     CrossRef
  • Decreased Vagal Activity and Deviation in Sympathetic Activity Precedes Development of Diabetes
    Da Young Lee, Mi Yeon Lee, Jung Hwan Cho, Hyemi Kwon, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Won-Young Lee, Sung-Woo Park, Seungho Ryu, Se Eun Park
    Diabetes Care.2020; 43(6): 1336.     CrossRef
  • Efficacy and safety of ertugliflozin in East/Southeast Asian patients with type 2 diabetes mellitus
    Jie Liu, Shrita Patel, Nilo B. Cater, Larry Wu, Susan Huyck, Steven G. Terra, Anne Hickman, Amanda Darekar, Annpey Pong, Ira Gantz
    Diabetes, Obesity and Metabolism.2020; 22(4): 574.     CrossRef
  • Outcomes for Inappropriate Renal Dose Adjustment of Dipeptidyl Peptidase-4 Inhibitors in Patients With Type 2 Diabetes Mellitus: Population-Based Study
    Sangmo Hong, Kyungdo Han, Cheol-Young Park
    Mayo Clinic Proceedings.2020; 95(1): 101.     CrossRef
  • Longitudinal Study of Diabetic Differences between International Migrants and Natives among the Asian Population
    Heng Piao, Jae Moon Yun, Aesun Shin, Belong Cho
    Biomolecules & Therapeutics.2020; 28(1): 110.     CrossRef
  • Risk of active tuberculosis development in contacts exposed to infectious tuberculosis in congregate settings in Korea
    Shin Young Park, Sunmi Han, Young-Man Kim, Jieun Kim, Sodam Lee, Jiyeon Yang, Un-Na Kim, Mi-sun Park
    Scientific Reports.2020;[Epub]     CrossRef
  • The Combined Impact of Chronic Kidney Disease and Diabetes on the Risk of Colorectal Cancer Depends on Sex: A Nationwide Population-Based Study
    Hyung Jung Oh, Hye Ah Lee, Chang Mo Moon, Dong-Ryeol Ryu
    Yonsei Medical Journal.2020; 61(6): 506.     CrossRef
  • Coffee Consumption, Genetic Polymorphisms, and the Risk of Type 2 Diabetes Mellitus: A Pooled Analysis of Four Prospective Cohort Studies
    An Na Kim, Hyun Jeong Cho, Jiyoung Youn, Taiyue Jin, Moonil Kang, Joohon Sung, Jung Eun Lee
    International Journal of Environmental Research and Public Health.2020; 17(15): 5379.     CrossRef
  • Current findings of kidney biopsy including nephropathy associated with hypertension and diabetes mellitus in Korea
    Kipyo Kim, Sang Ho Lee, Sung Woo Lee, Jung Pyo Lee, Ho Jun Chin
    The Korean Journal of Internal Medicine.2020; 35(5): 1173.     CrossRef
  • A Diabetes-Related Dietary Pattern Is Associated with Incident Diabetes in Obese Men in the Korean Genome Epidemiology Study
    Hye Ah Lee, NaYeong Son, Won Kyung Lee, Hyesook Park
    The Journal of Nutrition.2019; 149(2): 323.     CrossRef
  • Associations of postmenopausal hormone therapy with metabolic syndrome among diabetic and non-diabetic women
    Ji-Eun Kim, Jaesung Choi, JooYong Park, Jong-koo Lee, Aesun Shin, Sang Min Park, Daehee Kang, Ji-Yeob Choi
    Maturitas.2019; 121: 76.     CrossRef
  • The changing epidemiology of herpes zoster over a decade in South Korea, 2006–2015
    Jae-Ki Choi, Sun Hee Park, Sanghyun Park, Sung-Yeon Cho, Hyo-Jin Lee, Si-Hyun Kim, Su-Mi Choi, Dong-Gun Lee, Jung-Hyun Choi, Jin-Hong Yoo
    Vaccine.2019; 37(36): 5153.     CrossRef
  • Prevalence of undiagnosed diabetes and pre-diabetes and its associated risk factors in Vietnam
    Van Dat Nguyen, Quang Mai Vien, Thai Hung Do, Cong Danh Phan, Huu Chau Nguyen, Van Tuyen Nguyen, Dinh Luong Nguyen, Won Seok Sir, Yun Chon
    Journal of Global Health Science.2019;[Epub]     CrossRef
  • Heterogeneous Trajectories of Cognitive Function in Older Adults with Diabetes: Findings from the Korean Longitudinal Study of Aging (KLoSA)
    Chanhee Kim, Min Jung Kim, Chang Gi Park
    Stress.2019; 27(1): 1.     CrossRef
  • The Effect of Coffee Consumption on the Prevalence of Diabetes Mellitus: The 2012–2016 Korea National Health and Nutrition Examination Survey
    Yejee Lim, Youngmi Park, Sun Kyu Choi, Soyeon Ahn, Jung Hun Ohn
    Nutrients.2019; 11(10): 2377.     CrossRef
  • Effects of sodium-glucose cotransporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors on diabetic retinopathy and its progression: A real-world Korean study
    Yoo-Ri Chung, Kyoung Hwa Ha, Kihwang Lee, Dae Jung Kim, Ping-Hsun Wu
    PLOS ONE.2019; 14(10): e0224549.     CrossRef
  • Letter: Projection of Diabetes Prevalence in Korean Adults for the Year 2030 Using Risk Factors Identified from National Data (Diabetes Metab J 2019;43:90–6)
    Bo Kyung Koo
    Diabetes & Metabolism Journal.2019; 43(2): 242.     CrossRef
  • Changes of computed tomography‐based body composition after adrenalectomy in patients with endogenous hypercortisolism
    Namki Hong, Jooyeon Lee, Cheol Ryong Ku, Kichang Han, Cho Rok Lee, Sang Wook Kang, Yumie Rhee
    Clinical Endocrinology.2019; 90(2): 267.     CrossRef
  • Estimating Lifetime Duration of Diabetes by Age and Gender in the Korean Population Using a Markov Model
    Seung Woo Cho, Seon Ha Kim, Young-Eun Kim, Seok-Jun Yoon, Min-Woo Jo
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Hospital-Based Korean Diabetes Prevention Study: A Prospective, Multi-Center, Randomized, Open-Label Controlled Study
    Sang Youl Rhee, Suk Chon, Kyu Jeung Ahn, Jeong-Taek Woo
    Diabetes & Metabolism Journal.2019; 43(1): 49.     CrossRef
  • Medical Big Data Is Not Yet Available: Why We Need Realism Rather than Exaggeration
    Hun-Sung Kim, Dai-Jin Kim, Kun-Ho Yoon
    Endocrinology and Metabolism.2019; 34(4): 349.     CrossRef
  • Implementation of the Chronic Disease Care System and its association with health care costs and continuity of care in Korean adults with type 2 diabetes mellitus
    Woorim Kim, Yoon Soo Choy, Sang Ah Lee, Eun-Cheol Park
    BMC Health Services Research.2018;[Epub]     CrossRef
  • Trends in diabetes prevalence among Korean adults based on Korean National Health and Nutrition Examination Surveys III–VI
    Jae-woo Lee, Hee-Taik Kang, Hyoung-Ji Lim, Byoungjin Park
    Diabetes Research and Clinical Practice.2018; 138: 57.     CrossRef
  • Insulin Resistance and the Risk of Diabetes and Dysglycemia in Korean General Adult Population
    Jong Ha Baek, Hosu Kim, Kyong Young Kim, Jaehoon Jung
    Diabetes & Metabolism Journal.2018; 42(4): 296.     CrossRef
  • Relationship Between Circulating Netrin-1 Concentration, Impaired Fasting Glucose, and Newly Diagnosed Type 2 Diabetes
    Jisook Yim, Gyuri Kim, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Jeong-Ho Kim, Jin Won Cho, Sang-Guk Lee, Yong-ho Lee
    Frontiers in Endocrinology.2018;[Epub]     CrossRef
  • Serum metabolite profile associated with incident type 2 diabetes in Koreans: findings from the Korean Genome and Epidemiology Study
    Soo Jin Yang, So-Young Kwak, Garam Jo, Tae-Jin Song, Min-Jeong Shin
    Scientific Reports.2018;[Epub]     CrossRef
  • Trends in the prevalence of metabolic syndrome and its components in South Korea: Findings from the Korean National Health Insurance Service Database (2009–2013)
    Seung Eun Lee, Kyungdo Han, Yu Mi Kang, Seon-Ok Kim, Yun Kyung Cho, Kyung Soo Ko, Joong-Yeol Park, Ki-Up Lee, Eun Hee Koh, Ying-Mei Feng
    PLOS ONE.2018; 13(3): e0194490.     CrossRef
  • Effect of Change in Total Cholesterol Levels on Cardiovascular Disease Among Young Adults
    Su‐Min Jeong, Seulggie Choi, Kyuwoong Kim, Sung Min Kim, Gyeongsil Lee, Seong Yong Park, Yeon‐Yong Kim, Joung Sik Son, Jae‐Moon Yun, Sang Min Park
    Journal of the American Heart Association.2018;[Epub]     CrossRef
  • Age, sex, and the association of chronic kidney disease with all-cause mortality in Buddhist priests
    Hyo Jin Kim, Yunmi Kim, Sejoong Kim, Ho Jun Chin, Hajeong Lee, Jung Pyo Lee, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Deuk-Young Nah, Sung Joon Shin, Kyung Soo Kim, Jae Yoon Park, Kyung Don Yoo
    Medicine.2018; 97(45): e13099.     CrossRef
  • Association of change in total cholesterol level with mortality: A population-based study
    Su-Min Jeong, Seulggie Choi, Kyuwoong Kim, Sung-Min Kim, Gyeongsil Lee, Joung Sik Son, Jae-Moon Yun, Sang Min Park, Katriina Aalto-Setala
    PLOS ONE.2018; 13(4): e0196030.     CrossRef
  • High hemoglobin levels are associated with decreased risk of diabetic retinopathy in Korean type 2 diabetes
    Min-Kyung Lee, Kyung-Do Han, Jae-Hyuk Lee, Seo-Young Sohn, Jee-Sun Jeong, Mee-Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
    Scientific Reports.2018;[Epub]     CrossRef
  • Impact of systemic inflammation on the relationship between insulin resistance and all-cause and cancer-related mortality
    Da Young Lee, Eun-Jung Rhee, Yoosoo Chang, Chong Il Sohn, Ho-Cheol Shin, Seungho Ryu, Won-Young Lee
    Metabolism.2018; 81: 52.     CrossRef
  • The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus
    Il Young Kim, Sang Soo Kim, Hye Won Lee, Sun Sik Bae, Hong Koo Ha, Eun Soon Jung, Min Young Lee, Miyeun Han, Harin Rhee, Eun Young Seong, Dong Won Lee, Soo Bong Lee, David H. Lovett, Sang Heon Song
    BMC Nephrology.2018;[Epub]     CrossRef
  • The optimal cut-off of blood pressure related to left ventricular diastolic dysfunction and remodeling in Asian diabetic patients
    Ju Young Jung, Sung Keun Park, Jae-Hong Ryoo, Chang-Mo Oh, Jeong Gyu Kang, Kanghee Moon, Keum Ok Lee, Joong-Myung Choi
    Journal of Cardiology.2018; 71(1): 16.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
  • Factors Associated with Smoking Cessation Intention among Current Smokers with Diabetes: Analysis of the 2013 Community Health Survey in Korea
    Young-Hoon Lee, Jum Suk Ko
    Korean Journal of Health Promotion.2017; 17(3): 184.     CrossRef
  • The differences in the incidence of diabetes mellitus and prediabetes according to the type of HMG-CoA reductase inhibitors prescribed in Korean patients
    Tong Min Kim, Hyunah Kim, Yoo Jin Jeong, Sun Jung Baik, So Jung Yang, Seung-Hwan Lee, Jae-Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun-Ho Yoon, Hun-Sung Kim
    Pharmacoepidemiology and Drug Safety.2017; 26(10): 1156.     CrossRef
  • Analysis and comparison of the cost-effectiveness of statins according to the baseline low-density lipoprotein cholesterol level in Korea
    Y. J. Jeong, H. Kim, S. J. Baik, T. M. Kim, S. J. Yang, S.-H. Lee, J.-H. Cho, H. Lee, H. W. Yim, I. Y. Choi, K.-H. Yoon, H.-S. Kim
    Journal of Clinical Pharmacy and Therapeutics.2017; 42(3): 292.     CrossRef
  • Associations of Dietary Antioxidants and Risk of Type 2 Diabetes: Data from the 2007–2012 Korea National Health and Nutrition Examination Survey
    Dan Quansah, Kyungho Ha, Shinyoung Jun, Seong-Ah Kim, Sangah Shin, Gyung-Ah Wie, Hyojee Joung
    Molecules.2017; 22(10): 1664.     CrossRef
  • Accuracy of Capillary Blood Glucose Test When Fasting in Diabetes Patients or General Population: Performance Evaluation of G300 Based on ISO 15197:2013 Standards
    Young-min Jee, Min-hee Seo, Byung-wook Yoo, Sung-ho Hong, Choo-yon Cho, Yong-jin Cho, Jung-eun Oh, Kyung-suk Shin
    Korean Journal of Health Promotion.2017; 17(4): 259.     CrossRef
  • Increased Vascular Disease Mortality Risk in Prediabetic Korean Adults Is Mainly Attributable to Ischemic Stroke
    Nam Hoon Kim, Tae Yeon Kwon, Sungwook Yu, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yousung Park, Sin Gon Kim
    Stroke.2017; 48(4): 840.     CrossRef
Close layer
Obesity and Metabolism
Brain Regulation of Energy Metabolism
Eun Roh, Min-Seon Kim
Endocrinol Metab. 2016;31(4):519-524.   Published online December 20, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.4.519
  • 9,644 View
  • 175 Download
  • 52 Web of Science
  • 52 Crossref
AbstractAbstract PDFPubReader   

In healthy individuals, energy intake is in balance with energy expenditure, which helps to maintain a normal body weight. The brain's inability to control energy homeostasis underlies the pathology of hyperphagia and obesity. The brain detects body energy excess and deficit by sensing the levels of circulating metabolic hormones and nutrients and by receiving metabolic information from the periphery via the autonomic nervous system. A specialized neuronal network coordinates energy intake behavior and the metabolic processes affecting energy expenditure. Here, we briefly review neuronal mechanisms by which our body maintains energy balance.

Citations

Citations to this article as recorded by  
  • Hypothalamic AMP-Activated Protein Kinase as a Whole-Body Energy Sensor and Regulator
    Se Hee Min, Do Kyeong Song, Chan Hee Lee, Eun Roh, Min-Seon Kim
    Endocrinology and Metabolism.2024; 39(1): 1.     CrossRef
  • Adipokines from white adipose tissue in regulation of whole body energy homeostasis
    Bijayashree Sahu, Naresh C. Bal
    Biochimie.2023; 204: 92.     CrossRef
  • Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in a sex-specific manner
    Lukas Stilgenbauer, Juliana Bezerra Medeiros de Lima, Lucas Kniess Debarba, Manal Khan, Lisa Koshko, John J. Kopchick, Andrzej Bartke, Augusto Schneider, Marianna Sadagurski
    GeroScience.2023; 45(3): 1745.     CrossRef
  • Living high - training low model applied to C57BL/6J mice: Effects on physiological parameters related to aerobic fitness and acid-base balance
    Pedro Paulo Menezes Scariot, Marcelo Papoti, Emanuel Elias Camolese Polisel, Juan Bordon Orsi, Paul R. Van Ginkel, Tomas A. Prolla, Fúlvia Barros Manchado-Gobatto, Claudio Alexandre Gobatto
    Life Sciences.2023; 317: 121443.     CrossRef
  • Whole Transcriptome Analysis of Hypothalamus in Mice during Short-Term Starvation
    Eun-Young Oh, Byong Seo Park, Hye Rim Yang, Ho Gyun Lee, Thai Hien Tu, Sunggu Yang, Mi-Ryung Han, Jae Geun Kim
    International Journal of Molecular Sciences.2023; 24(4): 3204.     CrossRef
  • Hormonal Gut–Brain Signaling for the Treatment of Obesity
    Eun Roh, Kyung Mook Choi
    International Journal of Molecular Sciences.2023; 24(4): 3384.     CrossRef
  • Neuronal Blockade of Thyroid Hormone Signaling Increases Sensitivity to Diet-Induced Obesity in Adult Male Mice
    Eva Rial-Pensado, Laurence Canaple, Romain Guyot, Christoffer Clemmensen, Joëlle Wiersema, Shijia Wu, Sabine Richard, Anita Boelen, Timo D Müller, Miguel López, Frédéric Flamant, Karine Gauthier
    Endocrinology.2023;[Epub]     CrossRef
  • Genetic Contributors to Obesity
    Ramya Sivasubramanian, Sonali Malhotra
    Gastroenterology Clinics of North America.2023; 52(2): 323.     CrossRef
  • Neurocomputational mechanisms of food and physical activity decision-making in male adolescents
    Seung-Lark Lim, Amanda S. Bruce, Robin P. Shook
    Scientific Reports.2023;[Epub]     CrossRef
  • Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound
    Yaoheng Yang, Jinyun Yuan, Rachael L. Field, Dezhuang Ye, Zhongtao Hu, Kevin Xu, Lu Xu, Yan Gong, Yimei Yue, Alexxai V. Kravitz, Michael R. Bruchas, Jianmin Cui, Jonathan R. Brestoff, Hong Chen
    Nature Metabolism.2023; 5(5): 789.     CrossRef
  • Changes in hypothalamic mu-opioid receptor expression following acute olanzapine treatment in female rats: Implications for feeding behavior
    Maiken Krogsbaek, Nick Yao Larsen, Anne M. Landau, Connie Sanchez, Jens Randel Nyengaard
    Journal of Chemical Neuroanatomy.2023; 132: 102324.     CrossRef
  • Insulin Resistance and Glucose Metabolism during Infection
    Borros Arneth
    Endocrines.2023; 4(4): 685.     CrossRef
  • The PACAP Paradox: Dynamic and Surprisingly Pleiotropic Actions in the Central Regulation of Energy Homeostasis
    Nikki Le, Sarah Sayers, Veronica Mata-Pacheco, Edward J. Wagner
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • The Link Between Energy-Related Sensations and Metabolism: Implications for Treating Fatigue
    Marco Filippi, Rainer Krähenmann, Patrick Fissler
    Frontiers in Psychology.2022;[Epub]     CrossRef
  • Unaltered Tonic Inhibition in the Arcuate Nucleus of Diet-induced Obese Mice
    Moonsun Sa, Jung Moo Lee, Mingu Gordon Park, Jiwoon Lim, Jong Min Joseph Kim, Wuhyun Koh, Bo-Eun Yoon, C. Justin Lee
    Experimental Neurobiology.2022; 31(3): 147.     CrossRef
  • Hypothalamus–Muscle Parallel Induction of Metabolic Pathways Following Physical Exercise
    Almog Katz, Meital Gonen, Yael Shahar, Asael Roichman, Batia Lerrer, Haim Yosef Cohen
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • Monocarboxylate transporters (MCTs) in skeletal muscle and hypothalamus of less or more physically active mice exposed to aerobic training
    P.P.M. Scariot, F.B. Manchado-Gobatto, W.R. Beck, M. Papoti, P.R. Van Ginkel, C.A. Gobatto
    Life Sciences.2022; 307: 120872.     CrossRef
  • Obesity-Related Genes Expression in Testes and Sperm Parameters Respond to GLP-1 and Caloric Restriction
    Ana S. Correia, Sara C. Pereira, Tiago Morais, Ana D. Martins, Mariana P. Monteiro, Marco G. Alves, Pedro F. Oliveira
    Biomedicines.2022; 10(10): 2609.     CrossRef
  • A pilot study of contrast-enhanced electrical impedance tomography for real-time imaging of cerebral perfusion
    Yuyan Zhang, Jian’an Ye, Yang Jiao, Weirui Zhang, Tao Zhang, Xiang Tian, Xuetao Shi, Feng Fu, Liang Wang, Canhua Xu
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • Repercussions of maternal exposure to high-fat diet on offspring feeding behavior and body composition: a systematic review
    Wenicios Ferreira Chaves, Isabeli Lins Pinheiro, Jacqueline Maria da Silva, Raul Manhães-de-Castro, Raquel da Silva Aragão
    Journal of Developmental Origins of Health and Disease.2021; 12(2): 220.     CrossRef
  • Obesity-associated Pathways of Anthocyanins
    Elif YILDIZ, Metin GULDAS, Pinar ELLERGEZEN, Asli Gul ACAR, Ozan GURBUZ
    Food Science and Technology.2021; 41( suppl 1): 1.     CrossRef
  • Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism
    Ming-Liang Lee, Hirokazu Matsunaga, Yuki Sugiura, Takahiro Hayasaka, Izumi Yamamoto, Taiga Ishimoto, Daigo Imoto, Makoto Suematsu, Norifumi Iijima, Kazuhiro Kimura, Sabrina Diano, Chitoku Toda
    Nature Communications.2021;[Epub]     CrossRef
  • Sleep and Cardiovascular Risk
    Lyudmila Korostovtseva, Mikhail Bochkarev, Yurii Sviryaev
    Sleep Medicine Clinics.2021; 16(3): 485.     CrossRef
  • Evaluation and Management of Early Onset Genetic Obesity in Childhood
    Sonali Malhotra, Ramya Sivasubramanian, Gitanjali Srivastava
    Journal of Pediatric Genetics.2021; 10(03): 194.     CrossRef
  • Gene expression atlas of energy balance brain regions
    Maria Caterina De Rosa, Hannah J. Glover, George Stratigopoulos, Charles A. LeDuc, Qi Su, Yufeng Shen, Mark W. Sleeman, Wendy K. Chung, Rudolph L. Leibel, Judith Y. Altarejos, Claudia A. Doege
    JCI Insight.2021;[Epub]     CrossRef
  • New Peptides as Potential Players in the Crosstalk Between the Brain and Obesity, Metabolic and Cardiovascular Diseases
    Magdalena Czerwińska, Katarzyna Czarzasta, Agnieszka Cudnoch-Jędrzejewska
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • A putative role for lncRNAs in epigenetic regulation of memory
    Ashleigh B. Irwin, Rudhab Bahabry, Farah D. Lubin
    Neurochemistry International.2021; 150: 105184.     CrossRef
  • Alteration of Relative Rates of Biodegradation and Regeneration of Cervical Spine Cartilage through the Restoration of Arterial Blood Flow Access to Rhomboid Fossa: A Hypothesis
    Kirill V. Zhukov, Alexandre A. Vetcher, Bagrat A. Gasparuan, Alexander Y. Shishonin
    Polymers.2021; 13(23): 4248.     CrossRef
  • Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children
    E Breton, V Gagné-Ouellet, K Thibeault, R Guérin, Rj Van Lieshout, P Perron, Mf Hivert, L Bouchard
    Epigenetics.2020; 15(3): 323.     CrossRef
  • The dorsomedial hypothalamus and nucleus of the solitary tract as key regulators in a rat model of chronic obesity
    Chen Zhang, Pernille Barkholt, Jens Christian Nielsen, Ditte Dencker Thorbek, Kristoffer Rigbolt, Niels Vrang, David Paul Drucker Woldbye, Jacob Jelsing
    Brain Research.2020; 1727: 146538.     CrossRef
  • Hypothalamic NAD+-Sirtuin Axis: Function and Regulation
    Eun Roh, Min-Seon Kim
    Biomolecules.2020; 10(3): 396.     CrossRef
  • The Rho/Rac Guanine Nucleotide Exchange Factor Vav1 Regulates Hif-1α and Glut-1 Expression and Glucose Uptake in the Brain
    Jaewoo Hong, Yurim Kim, Sudhirkumar Yanpallewar, P. Charles Lin
    International Journal of Molecular Sciences.2020; 21(4): 1341.     CrossRef
  • Sirtuin (SIRT)-1: At the crossroads of puberty and metabolism
    Carlos F. Aylwin, Alejandro Lomniczi
    Current Opinion in Endocrine and Metabolic Research.2020; 14: 65.     CrossRef
  • Metabolomics Reveals the Alteration of Metabolic Pathway by Alpha-Melanocyte-Stimulating Hormone in B16F10 Melanoma Cells
    Seung-Ho Seo, Jae Kwon Jo, Eun-Ju Kim, Seong-Eun Park, Seo Yeon Shin, Kyung Mok Park, Hong-Seok Son
    Molecules.2020; 25(15): 3384.     CrossRef
  • Noninvasive real-time detection of cerebral blood perfusion in hemorrhagic shock rabbits based on whole-brain magnetic induction phase shift: an experimental study
    Wencai Pan, Wei Zhuang, Yinbao Chong, Mingxin Qin, Yang Li, Jingjing Xiao, Qing Wang, Shihui Zhang, Shuanglin Zhao, Peng Zhao
    Physiological Measurement.2020; 41(9): 095004.     CrossRef
  • Neurochemical regulators of food behavior for pharmacological treatment of obesity: current status and future prospects
    Gayane Sargis Vardanyan, Hasmik Samvel Harutyunyan, Michail Iosif Aghajanov, Ruben Sargis Vardanyan
    Future Medicinal Chemistry.2020; 12(20): 1865.     CrossRef
  • The Co-occurrence of Pediatric Obesity and ADHD: an Understanding of Shared Pathophysiology and Implications for Collaborative Management
    Valerie M. O’Hara, Jennifer L. Curran, Nancy T. Browne
    Current Obesity Reports.2020; 9(4): 451.     CrossRef
  • Constitutive Androstane Receptor: A Peripheral and a Neurovascular Stress or Environmental Sensor
    Fabiana Oliviero, Céline Lukowicz, Badreddine Boussadia, Isabel Forner-Piquer, Jean-Marc Pascussi, Nicola Marchi, Laila Mselli-Lakhal
    Cells.2020; 9(11): 2426.     CrossRef
  • Automated diffusion-based parcellation of the hypothalamus reveals subunit-specific associations with obesity
    Melanie Spindler, Jale Özyurt, Christiane M. Thiel
    Scientific Reports.2020;[Epub]     CrossRef
  • SIRT1 in Astrocytes Regulates Glucose Metabolism and Reproductive Function
    Irene Choi, Emily Rickert, Marina Fernandez, Nicholas J G Webster
    Endocrinology.2019; 160(6): 1547.     CrossRef
  • Hypothalamic mechanisms associated with corticotropin-releasing factor-induced anorexia in chicks
    Jinxin Wang, Justin Matias, Elizabeth R. Gilbert, Tetsuya Tachibana, Mark A. Cline
    Neuropeptides.2019; 74: 95.     CrossRef
  • HMG-CoA synthase 2 drives brain metabolic reprogramming in cocaine exposure
    Xue Shao, Yunxuan Tang, Hailei Long, Hui Gu, Jie Zhang, Pengchi Deng, Yinglan Zhao, Xiaobo Cen
    Neuropharmacology.2019; 148: 377.     CrossRef
  • The Effect of Feeding Behavior on Hypothalamus in Obese Type 2 Diabetic Rats with Glucagon-like Peptide-1 Receptor Agonist Intervention
    Ke Lu, Xiaoyan Chen, Jianhua Yan, Xinchun Li, Chen Huang, Qi Wan, Xuelian Deng, Qiao Zou
    Obesity Facts.2018; 11(3): 181.     CrossRef
  • The Long-Term Impact of High Levels of Alpha-Melanocyte-Stimulating Hormone in Energy Balance Among Obese Adolescents
    Ana Claudia Pelissari Kravchychyn, Raquel Munhoz da Silveira Campos, Flávia Campos Corgosinho, Deborah Cristina Landi Masquio, Sofia Emanuelle de Castro Ferreira Vicente, Yasmin Alaby Martins Ferreira, Patrícia Leão Silva, Aline de Piano Ganen, Lila Missa
    Annals of Nutrition and Metabolism.2018; 72(4): 279.     CrossRef
  • Psychopharmacological advances in eating disorders
    Hubertus Himmerich, Janet Treasure
    Expert Review of Clinical Pharmacology.2018; 11(1): 95.     CrossRef
  • Food engineering into the XXI century
    José Miguel Aguilera
    AIChE Journal.2018; 64(1): 2.     CrossRef
  • The Role of Glucagon-Like Peptide 1 (GLP1) in Type 3 Diabetes: GLP-1 Controls Insulin Resistance, Neuroinflammation and Neurogenesis in the Brain
    Choon Bae, Juhyun Song
    International Journal of Molecular Sciences.2017; 18(11): 2493.     CrossRef
  • “I Am I and My Bacterial Circumstances”: Linking Gut Microbiome, Neurodevelopment, and Depression
    Juan M. Lima-Ojeda, Rainer Rupprecht, Thomas C. Baghai
    Frontiers in Psychiatry.2017;[Epub]     CrossRef
  • Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity
    Katharina Timper, Jens C. Brüning
    Disease Models & Mechanisms.2017; 10(6): 679.     CrossRef
  • Brain glucose metabolism: Role of Wnt signaling in the metabolic impairment in Alzheimer’s disease
    Pedro Cisternas, Nibaldo C. Inestrosa
    Neuroscience & Biobehavioral Reviews.2017; 80: 316.     CrossRef
  • Astrocyte-Specific Deletion of Peroxisome-Proliferator Activated Receptor-γ Impairs Glucose Metabolism and Estrous Cycling in Female Mice
    Marina O Fernandez, Katherine Hsueh, Hyun Tae Park, Consuelo Sauceda, Vicky Hwang, Deepak Kumar, Sun Kim, Emily Rickert, Sumana Mahata, Nicholas J G Webster
    Journal of the Endocrine Society.2017; 1(11): 1332.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
Close layer
Thyroid
Mutation Profile of Well-Differentiated Thyroid Cancer in Asians
Young Shin Song, Jung Ah Lim, Young Joo Park
Endocrinol Metab. 2015;30(3):252-262.   Published online September 22, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.3.252
  • 4,952 View
  • 60 Download
  • 60 Web of Science
  • 52 Crossref
AbstractAbstract PDFPubReader   

Recent advances in molecular diagnostics have led to significant insights into the genetic basis of thyroid tumorigenesis. Among the mutations commonly seen in thyroid cancers, the vast majority are associated with the mitogen-activated protein kinase pathway. B-Raf proto-oncogene (BRAF) mutations are the most common mutations observed in papillary thyroid cancers (PTCs), followed by RET/PTC rearrangements and RAS mutations, while follicular thyroid cancers are more likely to harbor RAS mutations or PAX8/peroxisome proliferator-activated receptor γ (PPARγ) rearrangements. Beyond these more common mutations, alterations in the telomerase reverse transcriptase (TERT) promoter have recently been associated with clinicopathologic features, disease prognosis, and tumorigenesis in thyroid cancer. While the mutations underlying thyroid tumorigenesis are well known, the frequency of these mutations is strongly associated with geography, with clear differences reported between Asian and Western countries. Of particular interest is the prevalence of BRAF mutations, with Korean patients exhibiting the highest rate of BRAF-associated thyroid cancers in the world. Here, we review the prevalence of each of the most common mutations in Asian and Western countries, and identify the characteristics of well-differentiated thyroid cancer in Asians.

Citations

Citations to this article as recorded by  
  • BRAF V600E Mutation Lacks Association with Poorer Clinical Prognosis in Papillary Thyroid Carcinoma
    Hon-Fan Lai, Jen-Fan Hang, Po-Chung Kuo, Chin-Sung Kuo, San-Fan Yao, Jui-Yu Chen, Chen-Hsen Lee
    Annals of Surgical Oncology.2024;[Epub]     CrossRef
  • Clinical value of multi-gene testing in distinguishing benign and malignant thyroid nodules
    Murui Zhang, Xiaotong Hu, Lunming Liu, Yihong Wang, Junchang Jiang, Hui Li, Weiqiang Fei, Tingting Zhong, Zhinong Jiang
    Medicine.2024; 103(4): e35960.     CrossRef
  • The Association of Socioeconomic Factors and Well-Differentiated Thyroid Cancer
    Andrew Bonner, Brendon Herring, Rongzhi Wang, Andrea Gillis, Polina Zmijewski, Brenessa Lindeman, Jessica Fazendin, Herbert Chen
    Journal of Surgical Research.2023; 283: 973.     CrossRef
  • BRAFV600E and TERT promoter C228T mutations on ThyroSeq v3 analysis of delayed skin metastasis from papillary thyroid cancer: a case report and literature review
    Jee-Hye Choi, Hyeong Won Yu, Ja Kyung Lee, Woochul Kim, June Young Choi, Hee Young Na, So Yeon Park, Chang Ho Ahn, Jae Hoon Moon, Sang Il Choi, Ho-Young Lee, Won Woo Lee, Wonjae Cha, Woo-Jin Jeong
    World Journal of Surgical Oncology.2023;[Epub]     CrossRef
  • Less is more meets do more with less: Exploring differences in thyroid FNA molecular testing between Asian and Western practices
    Michiya Nishino
    Cancer Cytopathology.2023; 131(7): 421.     CrossRef
  • Histological and Genetic Diversity in Ovarian Mucinous Carcinomas: A Pilot Study
    Sultana Razia, Kentaro Nakayama, Hitomi Yamashita, Tomoka Ishibashi, Masako Ishikawa, Kosuke Kanno, Seiya Sato, Satoru Kyo
    Current Oncology.2023; 30(4): 4052.     CrossRef
  • Effective Use of microRNA, BRAF and Sonographic Risk Assessment in Bethesda III Thyroid Nodules Requires a Different Approach to Nodules with Features of Nuclear Atypia and Other Types of Atypia
    Dorota Słowińska-Klencka, Bożena Popowicz, Dominika Kulczycka-Wojdala, Bożena Szymańska, Joanna Duda-Szymańska, Martyna Wojtaszek-Nowicka, Krzysztof Kaczka, Mariusz Klencki
    Cancers.2023; 15(17): 4287.     CrossRef
  • Long-Term Changes in the Mortality Rates of Thyroid Cancer in Korea: Analysis of Korean National Data from 1985 to 2020
    Yun Mi Choi, Min-Ju Kim, Jiwoo Lee, Mi Kyung Kwak, Min Ji Jeon, Tae Yong Kim, Eun-Gyoung Hong, Won Bae Kim, Won Gu Kim
    Endocrinology and Metabolism.2023; 38(5): 588.     CrossRef
  • 遺伝子から頭頸部がんを診る : 甲状腺癌 (分化癌を中心に)
    季吉 森谷
    Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo).2023; 126(12): 1277.     CrossRef
  • Toward Systems-Level Metabolic Analysis in Endocrine Disorders and Cancer
    Aliya Lakhani, Da Hyun Kang, Yea Eun Kang, Junyoung O. Park
    Endocrinology and Metabolism.2023; 38(6): 619.     CrossRef
  • Risk and Prognostic Factors for BRAFV600E Mutations in Papillary Thyroid Carcinoma
    Xiaojing Wei, Xiaodong Wang, Jie Xiong, Chen Li, Yixuan Liao, Yongjun Zhu, Jingxin Mao, Gitana Maria Aceto
    BioMed Research International.2022; 2022: 1.     CrossRef
  • Disparities in the impact of the AJCC 8th edition staging system on differentiated thyroid cancer outcomes
    Juan A. Santamaria‐Barria, Amanda N. Graff‐Baker, Shu‐Ching Chang, Adam Khader, Anthony J. Scholer, Mary Garland‐Kledzik, Melanie Goldfarb
    Head & Neck.2022; 44(10): 2129.     CrossRef
  • Relationship Between The BRAF V600E And Tumor Size, Lymph Node, And Distant Metastasis In Papillary Thyroid Carcinoma
    Edmond Rukmana Wikanta, Yan Wisnu Prajoko, Benny Issakh, Hermawan Istiadi, Dik Puspasari
    Russian Open Medical Journal.2022;[Epub]     CrossRef
  • Lactate Dehydrogenase A as a Potential New Biomarker for Thyroid Cancer
    Eun Jeong Ban, Daham Kim, Jin Kyong Kim, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung, Kunhong Kim
    Endocrinology and Metabolism.2021; 36(1): 96.     CrossRef
  • Association of Hyperparathyroidism and Papillary Thyroid Cancer: A Multicenter Retrospective Study (Endocrinol Metab 2020;35:925-32, Chaiho Jeong et al.)
    Chaiho Jeong, Jeonghoon Ha, Moo Il Kang
    Endocrinology and Metabolism.2021; 36(1): 205.     CrossRef
  • Molecular pathogenesis of pediatric thyroid carcinoma
    Norisato Mitsutake, Vladimir Saenko
    Journal of Radiation Research.2021; 62(Supplement): i71.     CrossRef
  • The Incidence of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Meta-Analysis Assessing Worldwide Impact of the Reclassification
    Chanchal Rana, Huy Gia Vuong, Thu Quynh Nguyen, Hoang Cong Nguyen, Chan Kwon Jung, Kennichi Kakudo, Andrey Bychkov
    Thyroid.2021;[Epub]     CrossRef
  • The Association Between Radioiodine Refractory in Papillary Thyroid Carcinoma, Sodium/Iodide Symporter Expression, and BRAFV600E Mutation
    Tauangtham Anekpuritanang, Maythad Uataya, Apichaya Claimon, Natthawadee Laokulrath, Warut Pongsapich, Paveena Pithuksurachai
    OncoTargets and Therapy.2021; Volume 14: 3959.     CrossRef
  • Genomic landscape of metastatic papillary thyroid carcinoma and novel biomarkers for predicting distant metastasis
    Xiabin Lan, Hua Bao, Xinyang Ge, Jun Cao, Xiaojun Fan, Qihong Zhang, Kaihua Liu, Xian Zhang, Zhuo Tan, Chuanming Zheng, Ao Wang, Chao Chen, Xin Zhu, Jiafeng Wang, Jiajie Xu, Xuhang Zhu, Xue Wu, Xiaonan Wang, Yang Shao, Minghua Ge
    Cancer Science.2020; 111(6): 2163.     CrossRef
  • Did Introducing a New Category of Thyroid Tumors (Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features) Decrease the Risk of Malignancy for the Diagnostic Categories in the Bethesda System for Reporting Thyroid Cytopathology?
    Janusz Kopczyński, Agnieszka Suligowska, Kornelia Niemyska, Iwona Pałyga, Agnieszka Walczyk, Danuta Gąsior-Perczak, Artur Kowalik, Kinga Hińcza, Ryszard Mężyk, Stanisław Góźdź, Aldona Kowalska
    Endocrine Pathology.2020; 31(2): 143.     CrossRef
  • The Significance of Transcriptomic Signatures in the Multifocal Papillary Thyroid Carcinoma: Two mRNA Expression Patterns with Distinctive Clinical Behavior from The Cancer Genome Atlas (TCGA) Database
    Yea Eun Kang, Boyoung Hwang, Ju Hee Lee, Minho Shong, Hyon-Seung Yi, Bon Seok Koo, Dong Jin Lee
    International Journal of Thyroidology.2020; 13(1): 1.     CrossRef
  • High Genetic Diversity and No Evidence of Clonal Relation in Synchronous Thyroid Carcinomas Associated with Hashimoto’s Thyroiditis: A Next-Generation Sequencing Analysis
    Csaba Molnár, Emese Sarolta Bádon, Attila Mokánszki, Anikó Mónus, Lívia Beke, Ferenc Győry, Endre Nagy, Gábor Méhes
    Diagnostics.2020; 10(1): 48.     CrossRef
  • Low Prevalence of TERT Promoter, BRAF and RAS Mutations in Papillary Thyroid Cancer in the Greek Population
    Marilena Argyropoulou, Aristidis S. Veskoukis, Pagona-Maria Karanatsiou, Aikaterini Manolakelli, Ifigenia Kostoglou-Athanassiou, George Vilaras, Andreas Karameris, Kalliopi Liadaki
    Pathology & Oncology Research.2020; 26(1): 347.     CrossRef
  • Predominant DICER1 Pathogenic Variants in Pediatric Follicular Thyroid Carcinomas
    Young Ah Lee, Sun-Wha Im, Kyeong Cheon Jung, Eun-Jae Chung, Choong Ho Shin, Jong-Il Kim, Young Joo Park
    Thyroid.2020; 30(8): 1120.     CrossRef
  • BRAF and KRAS mutations in papillary thyroid carcinoma in the United Arab Emirates
    Suhail Al-Salam, Charu Sharma, Bachar Afandi, Khaled Al Dahmani, Ali S. Al-Zahrani, Amal Al Shamsi, Juma Al Kaabi, Paula Soares
    PLOS ONE.2020; 15(4): e0231341.     CrossRef
  • VE1 Immunohistochemistry Improves the Limit of Genotyping for Detecting BRAFV600E Mutation in Papillary Thyroid Cancer
    Sonam Choden, Somboon Keelawat, Chan Kwon Jung, Andrey Bychkov
    Cancers.2020; 12(3): 596.     CrossRef
  • Highly Sensitive and Specific Molecular Test for Mutations in the Diagnosis of Thyroid Nodules: A Prospective Study of BRAF-Prevalent Population
    Yoon Young Cho, So Young Park, Jung Hee Shin, Young Lyun Oh, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim, Hyun Sook Yim, Yoo-Li Kim, Chang-Seok Ki, Tae Hyuk Kim, Jae Hoon Chung, Sun Wook Kim
    International Journal of Molecular Sciences.2020; 21(16): 5629.     CrossRef
  • Is there adenoma-carcinoma sequence between benign adenoma and papillary cancer of thyroid: A genomic linkage study
    Ramesh Bangaraiahgari, Ramakanth Bhargav Panchangam, Pradeep Puthenveetil, Sabaretnam Mayilvaganan, Rajesh Bangaraiahgari, Rajkiran reddy Banala, Poongkodi Karunakaran, Rafi Md
    Annals of Medicine and Surgery.2020; 60: 695.     CrossRef
  • Genomic Characterization of Differentiated Thyroid Carcinoma
    Young Shin Song, Young Joo Park
    Endocrinology and Metabolism.2019; 34(1): 1.     CrossRef
  • Association between BRAFV600E Mutations and Clinicopathological Features of Papillary Thyroid Microcarcinoma (PTMC)
    Sung Min Lee, Cho Rok Lee, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung, Cheong Soo Park
    Journal of Endocrine Surgery.2019; 19(3): 76.     CrossRef
  • Combined quantitation of HMGA2 mRNA, microRNAs, and mitochondrial-DNA content enables the identification and typing of thyroid tumors in fine-needle aspiration smears
    Sergei E. Titov, Mikhail K. Ivanov, Pavel S. Demenkov, Gevork A. Katanyan, Eugenia S. Kozorezova, Anastasia V. Malek, Yulia A. Veryaskina, Igor F. Zhimulev
    BMC Cancer.2019;[Epub]     CrossRef
  • Interaction of BRAF-induced ETS factors with mutant TERT promoter in papillary thyroid cancer
    Young Shin Song, Seong-Keun Yoo, Hwan Hee Kim, Gyeongseo Jung, Ah-Reum Oh, Ji-Young Cha, Su-jin Kim, Sun Wook Cho, Kyu Eun Lee, Jeong-Sun Seo, Young Joo Park
    Endocrine-Related Cancer.2019; 26(6): 629.     CrossRef
  • Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features in Asian Practice: Perspectives for Surgical Pathology and Cytopathology
    Andrey Bychkov, Chan Kwon Jung, Zhiyan Liu, Kennichi Kakudo
    Endocrine Pathology.2018; 29(3): 276.     CrossRef
  • Understanding Malignancies of the Thyroid Gland: Institutional Experience
    Jaimanti Bakshi, Sourabha Kumar Patro, Navjot Kaur, Naresh Kumar Panda, Grace Budhiraja
    Indian Journal of Otolaryngology and Head & Neck Surgery.2018; 70(4): 482.     CrossRef
  • Case–Control Study of Papillary Thyroid Carcinoma on Urinary and Dietary Iodine Status in South Korea
    Joon‐Hyop Lee, Ra‐Yeong Song, Jin Wook Yi, Hyeong Won Yu, Hyungju Kwon, Su‐jin Kim, Young Jun Chai, June Young Choi, Jae Hoon Moon, Kyu Eun Lee, Young Joo Park, Sue K. Park
    World Journal of Surgery.2018; 42(5): 1424.     CrossRef
  • Impact of non-invasive follicular thyroid neoplasm with papillary-like nuclear features on the Bethesda system for reporting thyroid cytopathology: a multi-institutional study in five Asian countries
    Andrey Bychkov, Somboon Keelawat, Shipra Agarwal, Deepali Jain, Chan Kwon Jung, SoonWon Hong, Chiung-Ru Lai, Shinya Satoh, Kennichi Kakudo
    Pathology.2018; 50(4): 411.     CrossRef
  • Genetic landscape of papillary thyroid carcinoma in the Chinese population
    Jialong Liang, Wanshi Cai, Dongdong Feng, Huajing Teng, Fengbiao Mao, Yi Jiang, Shanshan Hu, Xianfeng Li, Yujie Zhang, Baoguo Liu, Zhong Sheng Sun
    The Journal of Pathology.2018; 244(2): 215.     CrossRef
  • Aberrant expression of CD20 in thyroid cancer and its clinicopathologic significance
    Andrey Bychkov, Chan Kwon Jung
    Human Pathology.2018; 71: 74.     CrossRef
  • Molecular markers in well-differentiated thyroid cancer
    Anil K. D’Cruz, Richa Vaish, Abhishek Vaidya, Iain J. Nixon, Michelle D. Williams, Vincent Vander Poorten, Fernando López, Peter Angelos, Ashok R. Shaha, Avi Khafif, Alena Skalova, Alessandra Rinaldo, Jennifer L. Hunt, Alfio Ferlito
    European Archives of Oto-Rhino-Laryngology.2018; 275(6): 1375.     CrossRef
  • Meta-Analysis Confirms the Deleterious Effects of CombinedBRAFV600Eand Telomerase Reverse Transcriptase Promoter Mutations on the Course and Mortality of Papillary Thyroid Carcinoma
    Charles H. Emerson
    Clinical Thyroidology.2017; 29(5): 176.     CrossRef
  • Genetic Alterations and Their Clinical Implications in High-Recurrence Risk Papillary Thyroid Cancer
    Min-Young Lee, Bo Mi Ku, Hae Su Kim, Ji Yun Lee, Sung Hee Lim, Jong-Mu Sun, Se-Hoon Lee, Keunchil Park, Young Lyun Oh, Mineui Hong, Han-Sin Jeong, Young-Ik Son, Chung-Hwan Baek, Myung-Ju Ahn
    Cancer Research and Treatment.2017; 49(4): 906.     CrossRef
  • Frequent BRAF V600E and Absence of TERT Promoter Mutations Characterize Sporadic Pediatric Papillary Thyroid Carcinomas in Japan
    Naoki Oishi, Tetsuo Kondo, Tadao Nakazawa, Kunio Mochizuki, Tomohiro Inoue, Kazunari Kasai, Ippei Tahara, Tomonori Yabuta, Mitsuyoshi Hirokawa, Akira Miyauchi, Ryohei Katoh
    Endocrine Pathology.2017; 28(2): 103.     CrossRef
  • Predicting Factors for Bilaterality in Papillary Thyroid Carcinoma with Tumor Size <4 cm
    Seo Ki Kim, Inhye Park, Jung-Woo Woo, Jun Ho Lee, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim
    Thyroid.2017; 27(2): 207.     CrossRef
  • Low Rate of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features in Asian Practice
    Andrey Bychkov, Mitsuyoshi Hirokawa, Chan Kwon Jung, Zhiyan Liu, Yun Zhu, Soon Won Hong, Shinya Satoh, Chiung-Ru Lai, Lien Huynh, Kennichi Kakudo
    Thyroid.2017; 27(7): 983.     CrossRef
  • Changes in the clinicopathological characteristics and genetic alterations of follicular thyroid cancer
    Young Shin Song, Jung Ah Lim, Hye Sook Min, Min Joo Kim, Hoon Sung Choi, Sun Wook Cho, Jae Hoon Moon, Ka Hee Yi, Do Joon Park, Bo Youn Cho, Young Joo Park
    European Journal of Endocrinology.2017; 177(6): 465.     CrossRef
  • Effects of CoexistentBRAFV600EandTERTPromoter Mutations on Poor Clinical Outcomes in Papillary Thyroid Cancer: A Meta-Analysis
    Shinje Moon, Young Shin Song, Ye An Kim, Jung Ah Lim, Sun Wook Cho, Jae Hoon Moon, Seokyung Hahn, Do Joon Park, Young Joo Park
    Thyroid.2017; 27(5): 651.     CrossRef
  • TERT Promoter Mutation in an Aggressive Cribriform Morular Variant of Papillary Thyroid Carcinoma
    Eun Ji Oh, Sohee Lee, Ja Seong Bae, Yourha Kim, Sora Jeon, Chan Kwon Jung
    Endocrine Pathology.2017; 28(1): 49.     CrossRef
  • TERT Promoter Mutation Predicts Radioiodine-Refractory Character in Distant Metastatic Differentiated Thyroid Cancer
    Xue Yang, Jiao Li, Xiaoyi Li, Zhiyong Liang, Wen Gao, Jun Liang, Shujun Cheng, Yansong Lin
    Journal of Nuclear Medicine.2017; 58(2): 258.     CrossRef
  • Molecular Diagnosis Using Residual Liquid-Based Cytology Materials for Patients with Nondiagnostic or Indeterminate Thyroid Nodules
    Hyemi Kwon, Won Gu Kim, Markus Eszlinger, Ralf Paschke, Dong Eun Song, Mijin Kim, Suyeon Park, Min Ji Jeon, Tae Yong Kim, Young Kee Shong, Won Bae Kim
    Endocrinology and Metabolism.2016; 31(4): 586.     CrossRef
  • TERT promoter mutations and long-term survival in patients with thyroid cancer
    Tae Hyuk Kim, Young-Eun Kim, Soomin Ahn, Ji-Youn Kim, Chang-Seok Ki, Young Lyun Oh, Kyunga Kim, Jae Won Yun, Woong-Yang Park, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim, Sun Wook Kim, Jae Hoon Chung
    Endocrine-Related Cancer.2016; 23(10): 813.     CrossRef
  • Reply:
    Y. Che
    American Journal of Neuroradiology.2016; 37(1): E9.     CrossRef
  • Prognostic effects of TERT promoter mutations are enhanced by coexistence with BRAF or RAS mutations and strengthen the risk prediction by the ATA or TNM staging system in differentiated thyroid cancer patients
    Young Shin Song, Jung Ah Lim, Hoonsung Choi, Jae‐Kyung Won, Jae Hoon Moon, Sun Wook Cho, Kyu Eun Lee, Young Joo Park, Ka Hee Yi, Do Joon Park, Jeong‐Sun Seo
    Cancer.2016; 122(9): 1370.     CrossRef
Close layer
Obesity and Metabolism
Metabolic and Cardiovascular Implications of a Metabolically Healthy Obesity Phenotype
Mi Hae Seo, Eun-Jung Rhee
Endocrinol Metab. 2014;29(4):427-434.   Published online December 29, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.4.427
  • 4,296 View
  • 44 Download
  • 50 Web of Science
  • 49 Crossref
AbstractAbstract PDFPubReader   

Metabolically healthy obesity (MHO) is a new concept in which an individual may exhibit an obese phenotype in the absence of any metabolic abnormalities. There are a number of definitions of MHO that utilize a variety of components. The findings of clinical and basic studies indicate that subjects with MHO do not exhibit an increased mortality, an increased risk of cardiovascular disease, or an increased risk of type 2 diabetes mellitus, as compared to normal-weight controls. Although these findings imply that metabolic health is a more important factor than obesity, several studies have shown that subjects with MHO have a similar risk of metabolic or cardiovascular diseases as those with metabolically unhealthy obesity. Thus, there is still debate regarding not only the implications of the MHO phenotype but its very existence. Accordingly, future studies should focus on developing a unified definition of MHO and distinguishing subjects who will be at a high risk for metabolic and cardiovascular diseases.

Citations

Citations to this article as recorded by  
  • Effect of obesity and metabolic health on urolithiasis: A nationwide population-based study
    Changil Choi, Jong Keun Kim, Kyungdo Han, Young Goo Lee, Jun Hyun Han
    Investigative and Clinical Urology.2022; 63(1): 63.     CrossRef
  • The Influence of Obesity and Metabolic Health on Vascular Health
    Eun-Jung Rhee
    Endocrinology and Metabolism.2022; 37(1): 1.     CrossRef
  • Relationship between military test scores and obesity-related health risk scores in air defense troops
    Alexander Piddubny, Serhii Palevych, Vitaliy Kirpenko, Michael Anthonny Martinez Velez, Federico Anibal Martinez Velez
    Health, sport, rehabilitation.2022; 8(1): 71.     CrossRef
  • New metabolic health definition might not be a reliable predictor for mortality in the nonobese Chinese population
    Ziqiong Wang, Yan He, Liying Li, Muxin Zhang, Haiyan Ruan, Ye Zhu, Xin Wei, Jiafu Wei, Xiaoping Chen, Sen He
    BMC Public Health.2022;[Epub]     CrossRef
  • Nephrolithiasis: A Red Flag for Cardiovascular Risk
    Alessia Gambaro, Gianmarco Lombardi, Chiara Caletti, Flavio Luciano Ribichini, Pietro Manuel Ferraro, Giovanni Gambaro
    Journal of Clinical Medicine.2022; 11(19): 5512.     CrossRef
  • Differences of Regional Fat Distribution Measured by Magnetic Resonance Imaging According to Obese Phenotype in Koreans
    Ha-Neul Choi, Hyunjung Lim, Young-Seol Kim, Sang-Youl Rhee, Jung-Eun Yim
    Metabolic Syndrome and Related Disorders.2022; 20(10): 551.     CrossRef
  • Diagnostic accuracy of the waist-to-height ratio and other anthropometric indices for metabolically healthy obesity in the working population
    José-Miguel Guzmán-García, Manuel Romero-Saldaña, Guillermo Molina-Recio, Carlos Álvarez-Fernández, Elena Raya-Cano, Rafael Molina-Luque
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Tabebuia rosea (Bertol.) DC. ethanol extract attenuates body weight gain by activation of molecular mediators associated with browning
    Elsa Cecilia Pagaza-Straffon, Carla Elena Mezo-González, David Armando Chavaro-Pérez, Jorge Cornejo-Garrido, Laurence A. Marchat, Claudia G. Benítez-Cardoza, Maricruz Anaya-Reyes, Cynthia Ordaz-Pichardo
    Journal of Functional Foods.2021; 86: 104740.     CrossRef
  • A Study on Metabolic Health Status as a Risk Factor for Female Bladder Cancer Incidence: Analysis From the National Health Checkups Database of Korea
    Da Eun Han, Sun Tae Ahn, Jong Wook Kim, Mi Mi Oh, Du Geon Moon, Kyungdo Han, Hong Seok Park
    The Korean Journal of Urological Oncology.2021; 19(4): 223.     CrossRef
  • Thickness of epicardial fat tissue as a marker of various obesity phenotypes in young patients with bronchial asthma
    I. A. Solov'eva, I. V. Demko, E. A. Sobko, A. Yu. Kraposhina, N. V. Gordeeva, N. S. Eidemiller, D. A. Anikin, D. A. Anikina
    Russian Pulmonology.2020; 30(1): 7.     CrossRef
  • Health impact of the Anthropocene: the complex relationship between gut microbiota, epigenetics, and human health, using obesity as an example
    Cecilie Torp Austvoll, Valentina Gallo, Doreen Montag
    Global Health, Epidemiology and Genomics.2020;[Epub]     CrossRef
  • Obesity and Body Composition in Man and Woman: Associated Diseases and the New Role of Gut Microbiota
    Ennio Avolio, Paola Gualtieri , Lorenzo Romano, Claudio Pecorella, Simona Ferraro, Giuseppe Palma, Laura Di Renzo, Antonino De Lorenzo
    Current Medicinal Chemistry.2020; 27(2): 216.     CrossRef
  • Different Patterns of Left Ventricular Hypertrophy in Metabolically Healthy and Insulin-Resistant Obese Subjects
    Angela Sciacqua, Antonio Cimellaro, Luana Mancuso, Sofia Miceli, Velia Cassano, Maria Perticone, Teresa V. Fiorentino, Francesco Andreozzi, Elena Succurro, Giorgio Sesti, Francesco Perticone
    Nutrients.2020; 12(2): 412.     CrossRef
  • Phenotypic classification and biochemical profile of obesity for cardiovascular prevention
    Marco A. Perrone, Jagadish Babu Dasari, Alfredo Intorcia, Paola Gualtieri, Massimo Marche, Marco Di Luozzo, Giuseppe Merra, Sergio Bernardini, Francesco Romeo, Domenico Sergi
    Gazzetta Medica Italiana Archivio per le Scienze Mediche.2020;[Epub]     CrossRef
  • Are young Iranian women with metabolically healthy obesity at increased risk of CVD incidence?
    Seyed Ahmad Hosseini, Vahideh Aghamohammadi, Damoon Ashtary-Larky, Meysam Alipour, Matin Ghanavati, Nasrin Lamuchi-Deli
    Jornal Vascular Brasileiro.2020;[Epub]     CrossRef
  • Metabolically healthy obese phenotype and risk of cardiovascular disease: Results from the China Health and Retirement Longitudinal Study
    Haibin Li, Dian He, Deqiang Zheng, Endawoke Amsalu, Anxin Wang, Lixin Tao, Jin Guo, Xia Li, Wei Wang, Xiuhua Guo
    Archives of Gerontology and Geriatrics.2019; 82: 1.     CrossRef
  • Metabolic phenotypes of obese, overweight, and normal weight individuals and risk of chronic kidney disease: a systematic review and meta-analysis
    Shahab Alizadeh, Hamed Esmaeili, Mohammad Alizadeh, Elnaz Daneshzad, Loghman Sharifi, Hossein Radfar, Mohammad Kazem Radaei
    Archives of Endocrinology and Metabolism.2019;[Epub]     CrossRef
  • Metabolic health is more closely associated with decrease in lung function than obesity
    Hea Yon Lee, Hae Kyung Yang, Ho Jin Song, Hee Jae Chang, Ji Young Kang, Sang Haak Lee, Solji Han, Young Kyoon Kim, Anna Halama
    PLOS ONE.2019; 14(1): e0209575.     CrossRef
  • Relations of major dietary patterns and metabolically unhealthy overweight/obesity phenotypes among Iranian women
    Atieh Mirzababaei, Seyedeh Forough Sajjadi, Nasim Ghodoosi, Sara Pooyan, Hana Arghavani, Mir Saeed Yekaninejad, Khadijeh Mirzaei
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 322.     CrossRef
  • The Relationship between Thyroid Function and Different Obesity Phenotypes in Korean Euthyroid Adults
    Jeong Mi Kim, Bo Hyun Kim, Hyungi Lee, Eun Heui Kim, Mijin Kim, Jong Ho Kim, Yun Kyung Jeon, Sang Soo Kim, In Joo Kim, Yong Ki Kim
    Diabetes & Metabolism Journal.2019; 43(6): 867.     CrossRef
  • Risk of hypertension among different metabolic phenotypes: a systematic review and meta-analysis of prospective cohort studies
    Atieh Mirzababaei, Hadis Mozaffari, Sakineh Shab-Bidar, Alireza Milajerdi, Kurosh Djafarian
    Journal of Human Hypertension.2019; 33(5): 365.     CrossRef
  • Being Metabolically Healthy, the Most Responsible Factor for Vascular Health
    Eun-Jung Rhee
    Diabetes & Metabolism Journal.2018; 42(1): 19.     CrossRef
  • Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes
    Hye Soo Chung, Hyun Jung Lee, Soon Young Hwang, Ju-Hee Choi, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Dong Seop Choi, Sei Hyun Baik, Kyung Mook Choi
    International Journal of Endocrinology.2018; 2018: 1.     CrossRef
  • Obesity is more closely related with hepatic steatosis and fibrosis measured by transient elastography than metabolic health status
    Ji Hye Huh, Kwang Joon Kim, Seung Up Kim, Seung Hwan Han, Kwang-Hyub Han, Bong-Soo Cha, Choon Hee Chung, Byung-Wan Lee
    Metabolism.2017; 66: 23.     CrossRef
  • Can psychobiotics intake modulate psychological profile and body composition of women affected by normal weight obese syndrome and obesity? A double blind randomized clinical trial
    Antonino De Lorenzo, Micaela Costacurta, Giuseppe Merra, Paola Gualtieri, Giorgia Cioccoloni, Massimiliano Marchetti, Dimitrios Varvaras, Raffaella Docimo, Laura Di Renzo
    Journal of Translational Medicine.2017;[Epub]     CrossRef
  • The influence of physical activity on risk of cardiovascular disease in people who are obese but metabolically healthy
    Shinje Moon, Chang-Myung Oh, Moon-Ki Choi, Yoo-Kyung Park, Sukyung Chun, Minkyung Choi, Jae Myung Yu, Hyung Joon Yoo, Pedro Tauler
    PLOS ONE.2017; 12(9): e0185127.     CrossRef
  • Changes in Body Composition According to Age and Sex among Young Non-Diabetic Korean Adults: the Kangbuk Samsung Health Study
    Seul-Ki Kim, Yu-Hyun Kwon, Jung Hwan Cho, Da Young Lee, Se Eun Park, Hyung-Geun Oh, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
    Endocrinology and Metabolism.2017; 32(4): 442.     CrossRef
  • Impact of Mediterranean diet on metabolic syndrome, cancer and longevity
    Nicola Di Daniele, Annalisa Noce, Maria Francesca Vidiri, Eleonora Moriconi, Giulia Marrone, Margherita Annicchiarico-Petruzzelli, Gabriele D’Urso, Manfredi Tesauro, Valentina Rovella, Antonino De Lorenzo
    Oncotarget.2017; 8(5): 8947.     CrossRef
  • Characterization of lipid profile by nuclear magnetic resonance spectroscopy (1H NMR) of metabolically healthy obese women after weight loss with Mediterranean diet and physical exercise
    Enrique Rodriguez-Garcia, Josefina Ruiz-Nava, Sonia Santamaria-Fernandez, Jose Carlos Fernandez-Garcia, Antonio Vargas-Candela, Raquel Yahyaoui, Francisco J. Tinahones, Maria Rosa Bernal-Lopez, Ricardo Gomez-Huelgas
    Medicine.2017; 96(27): e7040.     CrossRef
  • Sex‐related differences in abdominal obesity impact on ischemic stroke risk
    A. Rodríguez‐Campello, J. Jiménez‐Conde, Á. Ois, E. Cuadrado‐Godia, E. Giralt‐Steinhauer, R. M. Vivanco, C. Soriano‐Tárraga, I. Subirana, D. Muñoz, A. Gómez‐González, A. Puig‐Pijoan, J. Roquer
    European Journal of Neurology.2017; 24(2): 397.     CrossRef
  • Letter: Utility of the Visceral Adiposity Index and Hypertriglyceridemic Waist Phenotype for Predicting Incident Hypertension (Endocrinol Metab 2017;32:221-9, Mohsen Janghorbani et al.)
    Eun-Jung Rhee
    Endocrinology and Metabolism.2017; 32(3): 396.     CrossRef
  • Clinical Characteristics of Non-Alcoholic Fatty Liver Disease Based on Analyses from the Kangbuk Samsung Health Study
    Eun-Jung Rhee
    The Journal of Korean Diabetes.2017; 18(2): 81.     CrossRef
  • Fatty liver disease determines the progression of coronary artery calcification in a metabolically healthy obese population
    Yu Mi Kang, Chang Hee Jung, Yun Kyung Cho, Seung Eun Lee, Min Jung Lee, Jenie Yoonoo Hwang, Eun Hee Kim, Joong-Yeol Park, Woo Je Lee, Hong-Kyu Kim, Petter Bjornstad
    PLOS ONE.2017; 12(4): e0175762.     CrossRef
  • Visceral adiposity index predicts the conversion of metabolically healthy obesity to an unhealthy phenotype
    Yu Mi Kang, Chang Hee Jung, Yun Kyung Cho, Jung Eun Jang, Jenie Yoonoo Hwang, Eun Hee Kim, Woo Je Lee, Joong-Yeol Park, Hong-Kyu Kim, Clemens Fürnsinn
    PLOS ONE.2017; 12(6): e0179635.     CrossRef
  • Vasculoprotective Effects of 3-Hydroxybenzaldehyde against VSMCs Proliferation and ECs Inflammation
    Byung Soo Kong, Soo Jung Im, Yang Jong Lee, Yoon Hee Cho, Yu Ri Do, Jung Woo Byun, Cheol Ryong Ku, Eun Jig Lee, Maria Cristina Vinci
    PLOS ONE.2016; 11(3): e0149394.     CrossRef
  • New obesity classification criteria as a tool for bariatric surgery indication
    Antonino De Lorenzo
    World Journal of Gastroenterology.2016; 22(2): 681.     CrossRef
  • Obesity, metabolic health, and mortality in adults: a nationwide population-based study in Korea
    Hae Kyung Yang, Kyungdo Han, Hyuk-Sang Kwon, Yong-Moon Park, Jae-Hyoung Cho, Kun-Ho Yoon, Moo-Il Kang, Bong-Yun Cha, Seung-Hwan Lee
    Scientific Reports.2016;[Epub]     CrossRef
  • Predictive Value of Triglyceride Glucose Index for the Risk of Incident Diabetes: A 4-Year Retrospective Longitudinal Study
    Da Young Lee, Eun Seo Lee, Ji Hyun Kim, Se Eun Park, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee, Won-Young Lee, Fernando Guerrero-Romero
    PLOS ONE.2016; 11(9): e0163465.     CrossRef
  • Association of meat and dairy consumption with normal weight metabolic obesity in men: the Qazvin Metabolic Diseases Study
    Sima Hashemipour, Neda Esmailzadehha, Mahdieh Mohammadzadeh, Amir Ziaee
    Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2016; 21(3): 419.     CrossRef
  • Obesity and Cancer—Opportunities to Break the Link
    Daniel F. Argolo, Clifford A. Hudis, Neil M. Iyengar
    Current Breast Cancer Reports.2016; 8(1): 22.     CrossRef
  • Circadian Rhythms of Carbohydrate Metabolism in Women with Different Types of Obesity
    B. B. Pinkhasov, V. G. Selyatinskaya, E. L. Astrakhantseva, E. V. Anufrienko
    Bulletin of Experimental Biology and Medicine.2016; 161(3): 323.     CrossRef
  • Serum metabolic biomarkers distinguish metabolically healthy peripherally obese from unhealthy centrally obese individuals
    Xiang Gao, Weidong Zhang, Yongbo Wang, Pardis Pedram, Farrell Cahill, Guangju Zhai, Edward Randell, Wayne Gulliver, Guang Sun
    Nutrition & Metabolism.2016;[Epub]     CrossRef
  • Prevalence of overweight/obesity, abdominal obesity and metabolic syndrome and atypical cardiometabolic phenotypes in the adult Romanian population: PREDATORR study
    S. Popa, M. Moţa, A. Popa, E. Moţa, C. Serafinceanu, C. Guja, D. Catrinoiu, N. Hâncu, R. Lichiardopol, C. Bala, A. Popa, G. Roman, G. Radulian, R. Timar, B. Mihai
    Journal of Endocrinological Investigation.2016; 39(9): 1045.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
  • Changes in Metabolic Health Status Over Time and Risk of Developing Type 2 Diabetes
    Seung-Hwan Lee, Hae Kyung Yang, Hee-Sung Ha, Jin-Hee Lee, Hyuk-Sang Kwon, Yong-Moon Park, Hyeon-Woo Yim, Moo-Il Kang, Won-Chul Lee, Ho-Young Son, Kun-Ho Yoon
    Medicine.2015; 94(40): e1705.     CrossRef
  • Adiposity Measurements and Non‐Surgical Periodontal Therapy Outcomes
    Wiem Bouaziz, Jean‐Luc Davideau, Henri Tenenbaum, Olivier Huck
    Journal of Periodontology.2015; 86(9): 1030.     CrossRef
  • Obesity and Cancer: Concepts and Challenges
    Daniel F. Argolo, Neil M. Iyengar, Clifford A. Hudis
    Indian Journal of Surgical Oncology.2015; 6(4): 390.     CrossRef
  • Vasodilator responses and endothelin-dependent vasoconstriction in metabolically healthy obesity and the metabolic syndrome
    Francesca Schinzari, Micaela Iantorno, Umberto Campia, Nadia Mores, Valentina Rovella, Manfredi Tesauro, Nicola Di Daniele, Carmine Cardillo
    American Journal of Physiology-Endocrinology and Metabolism.2015; 309(9): E787.     CrossRef
  • Adipokine Profiles and Metabolic Health
    Seung-Hwan Lee
    Endocrinology and Metabolism.2015; 30(2): 175.     CrossRef
Close layer
Adrenal gland
Recent Updates on the Diagnosis and Management of Cushing's Syndrome
Lynnette K. Nieman
Endocrinol Metab. 2018;33(2):139-146.   Published online June 21, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.2.139
  • 11,588 View
  • 707 Download
  • 50 Web of Science
  • 47 Crossref
AbstractAbstract PDFPubReader   ePub   

Cushing's syndrome, a potentially lethal disorder characterized by endogenous hypercortisolism, may be difficult to recognize, especially when it is mild and the presenting features are common in the general population. However, there is a need to identify the condition at an early stage, as it tends to progress, accruing additional morbidity and increasing mortality rates. Once a clinical suspicion is raised, screening tests involve timed measurement of urine, serum or salivary cortisol at baseline or after administration of dexamethasone, 1 mg. Each test has caveats, so that the choice of tests must be individualized for each patient. Once the diagnosis is established, and the cause is determined, surgical resection of abnormal tumor/tissue is the optimal treatment. When this cannot be achieved, medical treatment (or bilateral adrenalectomy) must be used to normalize cortisol production. Recent updates in screening for and treating Cushing's syndrome are reviewed here.

Citations

Citations to this article as recorded by  
  • Considerations for cutaneous physiologic changes of pregnancy that fail to resolve postpartum
    Madison J. Anzelc, Mark A. Bechtel
    International Journal of Dermatology.2023; 62(2): 190.     CrossRef
  • Hypertension in Turner syndrome: a review of proposed mechanisms, management and new directions
    Lily Jones, Joanne Blair, Daniel B. Hawcutt, Gregory Y.H. Lip, Alena Shantsila
    Journal of Hypertension.2023; 41(2): 203.     CrossRef
  • Methyl-Prednisolone and Betamethasone Induced Iatrogenic Cushing Syndrome - A Rare Case Report
    Faaiz Khan, Jumana Hakeem, Mitta Raghavendra, Sushanta Kumar Das, Vallala Venakata Rajesham, Tadikonda Rama Rao
    International Journal of Pharmaceutical Research and Allied Sciences.2023; 12(2): 40.     CrossRef
  • Toward Systems-Level Metabolic Analysis in Endocrine Disorders and Cancer
    Aliya Lakhani, Da Hyun Kang, Yea Eun Kang, Junyoung O. Park
    Endocrinology and Metabolism.2023; 38(6): 619.     CrossRef
  • Metabolic profile differences in ACTH‐dependent and ACTH‐independent Cushing syndrome
    Zhengyang Li, Chen Zhang, Chong Geng, Yongfeng Song
    Chronic Diseases and Translational Medicine.2022; 8(1): 36.     CrossRef
  • Stressing the need for validated measures of cortisol in HIV research: A scoping review
    Shayda A. Swann, Elizabeth M. King, Hélène C. F. Côté, Melanie C. M. Murray
    HIV Medicine.2022; 23(8): 880.     CrossRef
  • Concomitant coexistence of ACTH‐dependent and independent Cushing syndrome
    Ach Taieb, Saad Ghada, Gorchène Asma, Ben Abdelkrim Asma, Kacem Maha, Ach Koussay
    Clinical Case Reports.2022;[Epub]     CrossRef
  • Incretin Response to Mixed Meal Challenge in Active Cushing’s Disease and after Pasireotide Therapy
    Mattia Barbot, Alessandro Mondin, Daniela Regazzo, Valentina Guarnotta, Daniela Basso, Carla Giordano, Carla Scaroni, Filippo Ceccato
    International Journal of Molecular Sciences.2022; 23(9): 5217.     CrossRef
  • Intermittent Blurry Vision: An Unexpected Presentation of Cushing’s Syndrome Due to Primary Bilateral Macronodular Adrenal Hyperplasia (PBMAH)
    Christopher Fernandez, Smriti Bhatia, Ariana Rucker, Lee Celio
    Cureus.2022;[Epub]     CrossRef
  • Recurrent Metatarsal Fractures in a Patient With Cushing Disease: A Case Report
    Jose Iturregui, Glenn Shi
    Cureus.2022;[Epub]     CrossRef
  • Recognising and diagnosing Cushing’s syndrome in primary care: challenging but not impossible
    Kate Scoffings, Damian Morris, Andrew Pullen, Sharon Temple, Anna Trigell, Mark Gurnell
    British Journal of General Practice.2022; 72(721): 399.     CrossRef
  • Recurrent Cushing Syndrome From Metastatic Adrenocortical Carcinoma With Fumarate Hydratase Allelic Variant
    Emily Silverman, Noor Addasi, Muaataz Azzawi, Ernesto Martinez Duarte, Dali Huang, Benjamin Swanson, Apar Kishor Ganti, Gwen Reiser, Abbey L. Fingeret, Anupam Kotwal
    AACE Clinical Case Reports.2022; 8(6): 259.     CrossRef
  • Multiple Bone Fractures in a Patient With Difficult-to-Treat Cushing’s Disease
    Sara Correia, Diogo Ramalho, Gustavo Rocha, Maria J Oliveira
    Cureus.2022;[Epub]     CrossRef
  • Management of patients on systemic steroids: An oral surgery perspective
    Vikash Patel, Shrina Nathwani, Naomi Rahman
    Dental Update.2022; 49(9): 749.     CrossRef
  • Importancia del cateterismo de senos petrosos inferiores en el diagnóstico de síndrome de Cushing, a propósito de un caso
    Clara Jiménez García, Paula Sirera Sirera, María Eugenia Torregrosa Quesada, Victoria González Bueno, Rocío Alfayate Guerra
    Advances in Laboratory Medicine / Avances en Medicina de Laboratorio.2022; 3(4): 411.     CrossRef
  • Cushing's Syndrome Behind Hypokalemia and Severe Infection: A Case Report
    Catarina Elias, Diana Oliveira, Maria Manuel Silva, Patrícia Lourenço
    Cureus.2022;[Epub]     CrossRef
  • Relevance of inferior petrosal sinus sampling in the diagnosis of Cushing’s syndrome: a case report
    Clara Jiménez García, Paula Sirera Sirera, María Eugenia Torregrosa Quesada, Victoria González Bueno, Rocío Alfayate Guerra
    Advances in Laboratory Medicine / Avances en Medicina de Laboratorio.2022; 3(4): 407.     CrossRef
  • Proximal muscle weakness as the sole manifestation of Cushing’s disease, misdiagnosed as dermatomyositis: a case report
    Marjan Jeddi, Mesbah Shams
    Journal of Medical Case Reports.2022;[Epub]     CrossRef
  • Differences in outcomes of bilateral adrenalectomy in patients with ectopic ACTH producing tumor of known and unknown origin
    Thomas Szabo Yamashita, Alaa Sada, Irina Bancos, William F. Young, Benzon M Dy, David R. Farley, Melanie L. Lyden, Geoffrey B. Thompson, Travis J. McKenzie
    The American Journal of Surgery.2021; 221(2): 460.     CrossRef
  • A key role for conservative treatment in the management of pituitary apoplexy
    Claire Marx, Muriel Rabilloud, Françoise Borson Chazot, Caroline Tilikete, Emmanuel Jouanneau, Gerald Raverot
    Endocrine.2021; 71(1): 168.     CrossRef
  • 7-T Magnetic Resonance Imaging in the Management of Brain Tumors
    Melanie A. Morrison, Janine M. Lupo
    Magnetic Resonance Imaging Clinics of North America.2021; 29(1): 83.     CrossRef
  • Medical therapy in severe hypercortisolism
    Júlia Vieira Oberger Marques, Cesar Luiz Boguszewski
    Best Practice & Research Clinical Endocrinology & Metabolism.2021; 35(2): 101487.     CrossRef
  • Metabolic changes in serum steroids for diagnosing and subtyping Cushing’s syndrome
    Chang Ho Ahn, Chaelin Lee, Jaeyoon Shim, Sung Hye Kong, Su-jin Kim, Yong Hwy Kim, Kyu Eun Lee, Chan Soo Shin, Jung Hee Kim, Man Ho Choi
    The Journal of Steroid Biochemistry and Molecular Biology.2021; 210: 105856.     CrossRef
  • Method-Specific Cortisol and Dexamethasone Thresholds Increase Clinical Specificity of the Dexamethasone Suppression Test for Cushing Syndrome
    Nora Vogg, Max Kurlbaum, Timo Deutschbein, Benedict Gräsl, Martin Fassnacht, Matthias Kroiss
    Clinical Chemistry.2021; 67(7): 998.     CrossRef
  • Untargeted Plasma Metabolomics Unravels a Metabolic Signature for Tissue Sensitivity to Glucocorticoids in Healthy Subjects: Its Implications in Dietary Planning for a Healthy Lifestyle
    Nicolas C. Nicolaides, Maria-Konstantina Ioannidi, Eleni Koniari, Ifigeneia Papageorgiou, Anastasia Bartzeliotou, Amalia Sertedaki, Maria I. Klapa, Evangelia Charmandari
    Nutrients.2021; 13(6): 2120.     CrossRef
  • Endocrine hypertension secondary to adrenal tumors: clinical course and predictive factors of clinical remission
    Uriel Clemente-Gutiérrez, Rafael H. Pérez-Soto, Juan D. Hernández-Acevedo, Nicole M. Iñiguez-Ariza, Enrique Casanueva-Pérez, Juan Pablo Pantoja-Millán, Mauricio Sierra-Salazar, Miguel F. Herrera, David Velázquez-Fernández
    Langenbeck's Archives of Surgery.2021; 406(6): 2027.     CrossRef
  • Development of 68Ga DOTA-CRH for PET/CT Imaging of ACTH-Dependent Cushing's Disease: Initial Study
    Jaya Shukla, Rakhee Vatsa, Rama Walia, Anupriya Chhabra, Nivedita Rana, Harmandeep Singh, Rajender Kumar, Bhagwant Rai Mittal
    Cancer Biotherapy and Radiopharmaceuticals.2021; 36(8): 642.     CrossRef
  • Cushing Syndrome Associated Myopathy: It Is Time for a Change
    Martin Reincke
    Endocrinology and Metabolism.2021; 36(3): 564.     CrossRef
  • Cushing’s disease presenting with psychosis
    Ahmed Saeed Mubarak Mohamed, Ahmed Iqbal, Suveera Prasad, Nigel Hoggard, Daniel Blackburn
    Practical Neurology.2021; 21(4): 351.     CrossRef
  • ACTH-independent Cushing's syndrome due to bilateral adrenocortical adenoma: A case report
    Majd Sharaf, Rama Al-Saqqa, Mouhammad Kourabi
    Radiology Case Reports.2021; 16(11): 3168.     CrossRef
  • A New Clinical Model to Estimate the Pre-Test Probability of Cushing’s Syndrome: The Cushing Score
    Mirko Parasiliti-Caprino, Fabio Bioletto, Tommaso Frigerio, Valentina D’Angelo, Filippo Ceccato, Francesco Ferraù, Rosario Ferrigno, Marianna Minnetti, Carla Scaroni, Salvatore Cannavò, Rosario Pivonello, Andrea Isidori, Fabio Broglio, Roberta Giordano, M
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Bilateral Adrenalectomy: Differences between Cushing Disease and Ectopic ACTH-Producing Tumors
    Thomas Szabo Yamashita, Alaa Sada, Irina Bancos, William F. Young, Benzon M. Dy, David R. Farley, Melanie L. Lyden, Geoffrey B. Thompson, Travis J. McKenzie
    Annals of Surgical Oncology.2020; 27(10): 3851.     CrossRef
  • Decision-Making in Artificial Intelligence: Is It Always Correct?
    Hun-Sung Kim
    Journal of Korean Medical Science.2020;[Epub]     CrossRef
  • Cushing's syndrome: Overview of clinical presentation, diagnostic tools and complications
    Mattia Barbot, Marialuisa Zilio, Carla Scaroni
    Best Practice & Research Clinical Endocrinology & Metabolism.2020; 34(2): 101380.     CrossRef
  • Cortisol Measurements in Cushing’s Syndrome: Immunoassay or Mass Spectrometry?
    Gregori Casals, Felicia Alexandra Hanzu
    Annals of Laboratory Medicine.2020; 40(4): 285.     CrossRef
  • Cardiopatías de origen endocrino: una etiología frecuentemente olvidada
    Laura Duque-González, Luis Miguel Ruiz-Velásquez, José Luis Torres-Grajales, Mauricio Duque-Ramírez
    Medicina y Laboratorio.2020; 24(3): 207.     CrossRef
  • Reference ranges of late-night salivary cortisol and cortisone measured by LC–MS/MS and accuracy for the diagnosis of Cushing’s syndrome
    F. Ponzetto, F. Settanni, M. Parasiliti-Caprino, F. Rumbolo, A. Nonnato, M. Ricciardo, E. Amante, G. Priolo, S. Vitali, L. Anfossi, E. Arvat, E. Ghigo, R. Giordano, G. Mengozzi
    Journal of Endocrinological Investigation.2020; 43(12): 1797.     CrossRef
  • Assessment of 1 mg Dexamethasone Suppression Test in Patients with Obesity Before Bariatric Surgery
    Dilek Gogas Yavuz, Tugce Apaydin, Hatice Gizem Gunhan, Meliha Melin Uygur
    Obesity Surgery.2020; 30(12): 4981.     CrossRef
  • Prospective Evaluation of Late-Night Salivary Cortisol and Cortisone by EIA and LC-MS/MS in Suspected Cushing Syndrome
    Joshua Kannankeril, Ty Carroll, James W Findling, Bradley Javorsky, Ian L Gunsolus, Jonathan Phillips, Hershel Raff
    Journal of the Endocrine Society.2020;[Epub]     CrossRef
  • Infantile Iatrogenic Cushing Syndrome due to Topical Steroids
    Lulwah Alkhuder, Horia Mawlawi
    Case Reports in Pediatrics.2019; 2019: 1.     CrossRef
  • Synchronous bilateral adrenalectomy in ACTH-dependent hypercortisolism: predictors, biomarkers and outcomes
    S. Chiloiro, A. Giampietro, M. Raffaelli, G. D’Amato, C. Bima, L. Lauretti, C. Anile, C. P. Lombardi, G. Rindi, R. Bellantone, L. De Marinis, A. Pontecorvi, A. Bianchi
    Endocrine.2019; 66(3): 642.     CrossRef
  • Low-dose etomidate for the management of severe hypercortisolaemia in different clinical scenarios: a case series and review of the literature
    Agnieszka Łebek-Szatańska, Karolina M. Nowak, Wojciech Zgliczyński, Elżbieta Baum, Agnieszka Żyłka, Lucyna Papierska
    Therapeutic Advances in Endocrinology and Metabolism.2019; 10: 204201881982554.     CrossRef
  • Drug design strategies for Cushing’s syndrome
    S. A. Usanov, A. V. Kliuchenovich, N. V. Strushkevich
    Expert Opinion on Drug Discovery.2019; 14(2): 143.     CrossRef
  • Pharmacological and analytical interference in hormone assays for diagnosis of adrenal incidentaloma
    Antoine-Guy Lopez, François Fraissinet, Herve Lefebvre, Valéry Brunel, Frédéric Ziegler
    Annales d'Endocrinologie.2019; 80(4): 250.     CrossRef
  • Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis
    Daniela D’Angelo, Marco De Martino, Claudio Arra, Alfredo Fusco
    Cancers.2019; 11(9): 1302.     CrossRef
  • Glucocorticoid Receptor Antagonist Administration Prevents Adrenal Gland Atrophy in an ACTH-Independent Cushing’s Syndrome Rat Model
    Atsushi Yasuda, Toshiro Seki, Yoshie Kametani, Masahiro Koizumi, Natsumi Kitajima, Masayuki Oki, Masami Seki, Takatoshi Kakuta, Masafumi Fukagawa
    International Journal of Endocrinology.2019; 2019: 1.     CrossRef
  • Cushing’s Disease
    Nishioka, Yamada
    Journal of Clinical Medicine.2019; 8(11): 1951.     CrossRef
Close layer
Miscellaneous
Medical Big Data Is Not Yet Available: Why We Need Realism Rather than Exaggeration
Hun-Sung Kim, Dai-Jin Kim, Kun-Ho Yoon
Endocrinol Metab. 2019;34(4):349-354.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.349
  • 5,573 View
  • 137 Download
  • 32 Web of Science
  • 46 Crossref
AbstractAbstract PDFPubReader   ePub   

Most people are now familiar with the concepts of big data, deep learning, machine learning, and artificial intelligence (AI) and have a vague expectation that AI using medical big data can be used to improve the quality of medical care. However, the expectation that big data could change the field of medicine is inconsistent with the current reality. The clinical meaningfulness of the results of research using medical big data needs to be examined. Medical staff needs to be clear about the purpose of AI that utilizes medical big data and to focus on the quality of this data, rather than the quantity. Further, medical professionals should understand the necessary precautions for using medical big data, as well as its advantages. No doubt that someday, medical big data will play an essential role in healthcare; however, at present, it seems too early to actively use it in clinical practice. The field continues to work toward developing medical big data and making it appropriate for healthcare. Researchers should continue to engage in empirical research to ensure that appropriate processes are in place to empirically evaluate the results of its use in healthcare.

Citations

Citations to this article as recorded by  
  • Current status of remote collaborative care for hypertension in medically underserved areas
    Seo Yeon Baik, Kyoung Min Kim, Hakyoung Park, Jiwon Shinn, Hun-Sung Kim
    Cardiovascular Prevention and Pharmacotherapy.2024; 6(1): 33.     CrossRef
  • Prediction of Cardiovascular Complication in Patients with Newly Diagnosed Type 2 Diabetes Using an XGBoost/GRU-ODE-Bayes-Based Machine-Learning Algorithm
    Joonyub Lee, Yera Choi, Taehoon Ko, Kanghyuck Lee, Juyoung Shin, Hun-Sung Kim
    Endocrinology and Metabolism.2024; 39(1): 176.     CrossRef
  • Dark Data in Real-World Evidence: Challenges, Implications, and the Imperative of Data Literacy in Medical Research
    Hun-Sung Kim
    Journal of Korean Medical Science.2024;[Epub]     CrossRef
  • Long-Term Risk of Cardiovascular Disease Among Type 2 Diabetes Patients According to Average and Visit-to-Visit Variations of HbA1c Levels During the First 3 Years of Diabetes Diagnosis
    Hyunah Kim, Da Young Jung, Seung-Hwan Lee, Jae-Hyoung Cho, Hyeon Woo Yim, Hun-Sung Kim
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Comparison of cardiocerebrovascular disease incidence between angiotensin converting enzyme inhibitor and angiotensin receptor blocker users in a real-world cohort
    Suehyun Lee, Hyunah Kim, Hyeon Woo Yim, Kim Hun-Sung, Ju Han Kim
    Journal of Applied Biomedicine.2023; 21(1): 7.     CrossRef
  • Multi-Omics and Management of Follicular Carcinoma of the Thyroid
    Thifhelimbilu Emmanuel Luvhengo, Ifongo Bombil, Arian Mokhtari, Maeyane Stephens Moeng, Demetra Demetriou, Claire Sanders, Zodwa Dlamini
    Biomedicines.2023; 11(4): 1217.     CrossRef
  • Correlation analysis of cancer incidence after pravastatin treatment
    Jin Yu, Raeun Kim, Jiwon Shinn, Man Young Park, Hun-Sung Kim
    Cardiovascular Prevention and Pharmacotherapy.2023; 5(2): 61.     CrossRef
  • A New Strategy for Evaluating the Quality of Laboratory Results for Big Data Research: Using External Quality Assessment Survey Data (2010–2020)
    Eun-Jung Cho, Tae-Dong Jeong, Sollip Kim, Hyung-Doo Park, Yeo-Min Yun, Sail Chun, Won-Ki Min
    Annals of Laboratory Medicine.2023; 43(5): 425.     CrossRef
  • Weight loss and side-effects of liraglutide and lixisenatide in obesity and type 2 diabetes mellitus
    Jeongmin Lee, Raeun Kim, Min-Hee Kim, Seung-Hwan Lee, Jae-Hyoung Cho, Jung Min Lee, Sang-Ah Jang, Hun-Sung Kim
    Primary Care Diabetes.2023; 17(5): 460.     CrossRef
  • Cohort profile for development of machine learning models to predict healthcare-related adverse events (Demeter): clinical objectives, data requirements for modelling and overview of data set for 2016–2018
    Svetlana Artemova, Ursula von Schenck, Rui Fa, Daniel Stoessel, Hadiseh Nowparast Rostami, Pierre-Ephrem Madiot, Jean-Marie Januel, Daniel Pagonis, Caroline Landelle, Meghann Gallouche, Christophe Cancé, Frederic Olive, Alexandre Moreau-Gaudry, Sigurd Pri
    BMJ Open.2023; 13(8): e070929.     CrossRef
  • The Present and Future of Artificial Intelligence-Based Medical Image in Diabetes Mellitus: Focus on Analytical Methods and Limitations of Clinical Use
    Ji-Won Chun, Hun-Sung Kim
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Construction and application on the training course of information literacy for clinical nurses
    Chao Wu, Yinjuan Zhang, Jing Wu, Linyuan Zhang, Juan Du, Lu Li, Nana Chen, Liping Zhu, Sheng Zhao, Hongjuan Lang
    BMC Medical Education.2023;[Epub]     CrossRef
  • Lightweight Histological Tumor Classification Using a Joint Sparsity-Quantization Aware Training Framework
    Dina Aboutahoun, Rami Zewail, Keiji Kimura, Mostafa I. Soliman
    IEEE Access.2023; 11: 119342.     CrossRef
  • Long-Term Cumulative Exposure to High γ-Glutamyl Transferase Levels and the Risk of Cardiovascular Disease: A Nationwide Population-Based Cohort Study
    Han-Sang Baek, Bongseong Kim, Seung-Hwan Lee, Dong-Jun Lim, Hyuk-Sang Kwon, Sang-Ah Chang, Kyungdo Han, Jae-Seung Yun
    Endocrinology and Metabolism.2023; 38(6): 770.     CrossRef
  • Comorbidity Patterns and Management in Inpatients with Endocrine Diseases by Age Groups in South Korea: Nationwide Data
    Sung-Soo Kim, Hun-Sung Kim
    Journal of Personalized Medicine.2023; 14(1): 42.     CrossRef
  • Angiotensin‐converting enzyme inhibitors versus angiotensin receptor blockers: New‐onset diabetes mellitus stratified by statin use
    Juyoung Shin, Hyunah Kim, Hyeon Woo Yim, Ju Han Kim, Suehyun Lee, Hun‐Sung Kim
    Journal of Clinical Pharmacy and Therapeutics.2022; 47(1): 97.     CrossRef
  • Physician Knowledge Base: Clinical Decision Support Systems
    Sira Kim, Eung-Hee Kim, Hun-Sung Kim
    Yonsei Medical Journal.2022; 63(1): 8.     CrossRef
  • Sodium-Glucose Cotransporter-2 Inhibitor-Related Diabetic Ketoacidosis: Accuracy Verification of Operational Definition
    Dong Yoon Kang, Hyunah Kim, SooJeong Ko, HyungMin Kim, Jiwon Shinn, Min-Gyu Kang, Sun-ju Byeon, Jeong-Hee Choi, Soo-Yong Shin, Hun-Sung Kim
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Drug Repositioning: Exploring New Indications for Existing Drug-Disease Relationships
    Hun-Sung Kim
    Endocrinology and Metabolism.2022; 37(1): 62.     CrossRef
  • A Study on Methodologies of Drug Repositioning Using Biomedical Big Data: A Focus on Diabetes Mellitus
    Suehyun Lee, Seongwoo Jeon, Hun-Sung Kim
    Endocrinology and Metabolism.2022; 37(2): 195.     CrossRef
  • Development of a predictive model for the side effects of liraglutide
    Jiyoung Min, Jiwon Shinn, Hun-Sung Kim
    Cardiovascular Prevention and Pharmacotherapy.2022; 4(2): 87.     CrossRef
  • Understanding and Utilizing Claim Data from the Korean National Health Insurance Service (NHIS) and Health Insurance Review & Assessment (HIRA) Database for Research
    Dae-Sung Kyoung, Hun-Sung Kim
    Journal of Lipid and Atherosclerosis.2022; 11(2): 103.     CrossRef
  • The Impact of the Association between Cancer and Diabetes Mellitus on Mortality
    Sung-Soo Kim, Hun-Sung Kim
    Journal of Personalized Medicine.2022; 12(7): 1099.     CrossRef
  • Development of Various Diabetes Prediction Models Using Machine Learning Techniques
    Juyoung Shin, Jaewon Kim, Chanjung Lee, Joon Young Yoon, Seyeon Kim, Seungjae Song, Hun-Sung Kim
    Diabetes & Metabolism Journal.2022; 46(4): 650.     CrossRef
  • Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes
    Han-sang Baek, Ji-Yeon Park, Jin Yu, Joonyub Lee, Yeoree Yang, Jeonghoon Ha, Seung Hwan Lee, Jae Hyoung Cho, Dong-Jun Lim, Hun-Sung Kim
    Endocrinology and Metabolism.2022; 37(4): 641.     CrossRef
  • Retrospective cohort analysis comparing changes in blood glucose level and body composition according to changes in thyroid‐stimulating hormone level
    Hyunah Kim, Da Young Jung, Seung‐Hwan Lee, Jae‐Hyoung Cho, Hyeon Woo Yim, Hun‐Sung Kim
    Journal of Diabetes.2022; 14(9): 620.     CrossRef
  • Long-Term Changes in HbA1c According to Blood Glucose Control Status During the First 3 Months After Visiting a Tertiary University Hospital
    Hyunah Kim, Da Young Jung, Seung-Hwan Lee, Jae-Hyoung Cho, Hyeon Woo Yim, Hun-Sung Kim
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Medication based machine learning to identify subpopulations of pediatric hemodialysis patients in an electronic health record database
    Autumn M. McKnite, Kathleen M. Job, Raoul Nelson, Catherine M.T. Sherwin, Kevin M. Watt, Simon C. Brewer
    Informatics in Medicine Unlocked.2022; 34: 101104.     CrossRef
  • Improving Machine Learning Diabetes Prediction Models for the Utmost Clinical Effectiveness
    Juyoung Shin, Joonyub Lee, Taehoon Ko, Kanghyuck Lee, Yera Choi, Hun-Sung Kim
    Journal of Personalized Medicine.2022; 12(11): 1899.     CrossRef
  • A Study on Weight Loss Cause as per the Side Effect of Liraglutide
    Jin Yu, Jeongmin Lee, Seung-Hwan Lee, Jae-Hyung Cho, Hun-Sung Kim, Heng Zhou
    Cardiovascular Therapeutics.2022; 2022: 1.     CrossRef
  • Risk Classification and Subphenotyping of Acute Kidney Injury: Concepts and Methodologies
    Javier A. Neyra, Jin Chen, Sean M. Bagshaw, Jay L. Koyner
    Seminars in Nephrology.2022; 42(3): 151285.     CrossRef
  • Estimation of sodium‐glucose cotransporter 2 inhibitor–related genital and urinary tract infections via electronic medical record–based common data model
    SooJeong Ko, HyungMin Kim, Jiwon Shinn, Sun‐ju Byeon, Jeong‐Hee Choi, Hun‐Sung Kim
    Journal of Clinical Pharmacy and Therapeutics.2021; 46(4): 975.     CrossRef
  • Blood glucose levels and bodyweight change after dapagliflozin administration
    Hyunah Kim, Seung‐Hwan Lee, Hyunyong Lee, Hyeon Woo Yim, Jae‐Hyoung Cho, Kun‐Ho Yoon, Hun‐Sung Kim
    Journal of Diabetes Investigation.2021; 12(9): 1594.     CrossRef
  • Artificial intelligence in healthcare: possibilities of patent protection
    T. N. Erivantseva, Yu. V. Blokhina
    FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Pharmacoepidemiology.2021; 14(2): 270.     CrossRef
  • Lack of Acceptance of Digital Healthcare in the Medical Market: Addressing Old Problems Raised by Various Clinical Professionals and Developing Possible Solutions
    Jong Il Park, Hwa Young Lee, Hyunah Kim, Jisan Lee, Jiwon Shinn, Hun-Sung Kim
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Prospect of Artificial Intelligence Based on Electronic Medical Records
    Suehyun Lee, Hun-Sung Kim
    Journal of Lipid and Atherosclerosis.2021; 10(3): 282.     CrossRef
  • Data Pseudonymization in a Range That Does Not Affect Data Quality: Correlation with the Degree of Participation of Clinicians
    Soo-Yong Shin, Hun-Sung Kim
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Development of a Predictive Model for Glycated Hemoglobin Values and Analysis of the Factors Affecting It
    HyeongKyu Park, Da Young Lee, So young Park, Jiyoung Min, Jiwon Shinn, Dae Ho Lee, Soon Hyo Kwon, Hun-Sung Kim, Nan Hee Kim
    Cardiovascular Prevention and Pharmacotherapy.2021; 3(4): 106.     CrossRef
  • Modeling of Changes in Creatine Kinase after HMG-CoA Reductase Inhibitor Prescription
    Hun-Sung Kim, Jiyoung Min, Jiwon Shinn, Oak-Kee Hong, Jang-Won Son, Seong-Su Lee, Sung-Rae Kim, Soon Jib Yoo
    Cardiovascular Prevention and Pharmacotherapy.2021; 3(4): 115.     CrossRef
  • TRAINING IN BIG DATA TECHNOLOGIES OF MEDICAL UNIVERSITY STUDENTS
    K.S ITINSON
    AZIMUTH OF SCIENTIFIC RESEARCH: PEDAGOGY AND PSYCHOLOGY.2021;[Epub]     CrossRef
  • Machine Learning Applications in Endocrinology and Metabolism Research: An Overview
    Namki Hong, Heajeong Park, Yumie Rhee
    Endocrinology and Metabolism.2020; 35(1): 71.     CrossRef
  • Lessons from Use of Continuous Glucose Monitoring Systems in Digital Healthcare
    Hun-Sung Kim, Kun-Ho Yoon
    Endocrinology and Metabolism.2020; 35(3): 541.     CrossRef
  • Apprehensions about Excessive Belief in Digital Therapeutics: Points of Concern Excluding Merits
    Hun-Sung Kim
    Journal of Korean Medical Science.2020;[Epub]     CrossRef
  • Medical Ethics in the Era of Artificial Intelligence Based on Medical Big Data
    Hae-Ran Na, Hun-Sung Kim
    The Journal of Korean Diabetes.2020; 21(3): 126.     CrossRef
  • Machine Learning Application in Diabetes and Endocrine Disorders
    Namki Hong, Heajeong Park, Yumie Rhee
    The Journal of Korean Diabetes.2020; 21(3): 130.     CrossRef
  • Real World Data and Artificial Intelligence in Diabetology
    Kwang Joon Kim
    The Journal of Korean Diabetes.2020; 21(3): 140.     CrossRef
Close layer
Thyroid
Graves' Disease: Can It Be Cured?
Wilmar M. Wiersinga
Endocrinol Metab. 2019;34(1):29-38.   Published online March 21, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.1.29
  • 15,701 View
  • 502 Download
  • 43 Web of Science
  • 45 Crossref
AbstractAbstract PDFPubReader   ePub   

Whether or not Graves' hyperthyroidism can be really cured, depends on the definition of “cure.” If eradication of thyroid hormone excess suffices for the label “cure,” then all patients can be cured because total thyroidectomy or high doses of 131I will abolish hyperthyroidism albeit at the expense of creating another disease (hypothyroidism) requiring lifelong medication with levothyroxine. I would not call this a “cure,” which I would like to define as a state with stable thyroid stimulating hormone (TSH), free thyroxine, and triiodothyronine serum concentrations in the normal range in the absence of any thyroid medication. Surgery and radioiodine are unlikely to result in so-defined cures, as their preferable aim as stated in guidelines is to cause permanent hypothyroidism. Discontinuation of antithyroid drugs is followed by 50% recurrences within 4 years; before starting therapy the risk of recurrences can be estimated with the Graves' Recurrent Events After Therapy (GREAT) score. At 20-year follow-up about 62% had developed recurrent hyperthyroidism, 8% had subclinical hypothyroidism, and 3% overt hypothyroidism related to TSH receptor blocking antibodies and thyroid peroxidase antibodies. Only 27% was in remission, and might be considered cured. If the definition of “cure” would also include the disappearance of thyroid antibodies in serum, the proportion of cured patients would become even lower.

Citations

Citations to this article as recorded by  
  • Multifunctional nanoparticle-mediated combining therapy for human diseases
    Xiaotong Li, Xiuju Peng, Makhloufi Zoulikha, George Frimpong Boafo, Kosheli Thapa Magar, Yanmin Ju, Wei He
    Signal Transduction and Targeted Therapy.2024;[Epub]     CrossRef
  • Prenatal double-hit with aluminium and cadmium mediate testicular atrophy and hypothalamic hypoplasia: the role of oxido-nitrergic stress and endocrine perturbations
    Emmanuel Okhue, Helen Ejiro Kadiri, Patrick Chukwuyenum Ichipi-Ifukor, Benneth Ben-Azu, Samuel Ogheneovo Asagba, Fidelis Ifeakachuku Achuba, John Chukwuma Oyem
    BioMetals.2024;[Epub]     CrossRef
  • Surgical outcome after thyroidectomy due to Graves’ disease and Lugol iodine treatment: a retrospective register-based cohort study
    Fredric Hedberg, Henrik Falhammar, Jan Calissendorff, Robert Bränström
    Endocrine.2024;[Epub]     CrossRef
  • Graves disease is associated with increased risk of clinical Alzheimer’s disease: evidence from the Medicare system
    Arseniy Pavlovich Yashkin, Stanislav Kolpakov, Svetlana Ukraintseva, Anatoliy Yashin, Igor Akushevich
    Clinical Diabetes and Endocrinology.2024;[Epub]     CrossRef
  • Predictors of Prolonged Euthyroidism After Radioactive Iodine Treatment for Graves’ Disease: A Pilot Study
    Jin-Ying Lu, Kuan-Hua Chen, Shyang-Rong Shih, Fang-Yu Wen, Wan-Chen Wu, Ting-Chu Chen, Fu-Chang Hu
    Endocrine Practice.2023; 29(2): 89.     CrossRef
  • Case of Graves’ disease recovery
    Andrey Valerievich Ushakov
    Journal of Clinical and Translational Endocrinology: Case Reports.2023; 27: 100139.     CrossRef
  • Outcomes of Radioactive Iodine Versus Surgery for the Treatment of Graves’ Disease: a Systematic Review and Meta-analysis
    Mohamed AbdAlla Salman, Mohamed Moustafa Assal, Ahmed Salman, Mohammed Elsherbiney
    Indian Journal of Surgery.2023;[Epub]     CrossRef
  • Association between high mobility group box-1 circulation level and Graves' ophthalmopathy
    Mohammad Robikhul Ikhsan, Nyoman Kertia, Supanji Supanji, Bambang Udji djoko Rianto, Dhite Bayu Nugroho
    F1000Research.2023; 12: 767.     CrossRef
  • New-onset and relapsed Graves’ disease following COVID-19 vaccination: a comprehensive review of reported cases
    Kan Chen, Yiyang Gao, Jing Li
    European Journal of Medical Research.2023;[Epub]     CrossRef
  • REVIEW OF SARS-CORONAVIRUS-2 REPERCUSSIONS ON THYROID GLAND IN THE CONTEXT OF HYPERTHYROIDISM
    SHUBHAM SINGH, MONIKA, RUPA MAZUMDER, AVIJIT MAZUMDER
    International Journal of Applied Pharmaceutics.2023; : 17.     CrossRef
  • Effectiveness and potential mechanism of Jiawei-Xiaoyao-San for hyperthyroidism: a systematic review
    Wenxin Ma, Xiaowen Zhang, Ruotong Zhao, Yang Tang, Xiaoyun Zhu, Longkun Liu, Mingyuan Xu, Ge Wang, Peiyue Peng, Jianping Liu, Zhaolan Liu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Associations of serum keratin 1 with thyroid function and immunity in Graves’ disease
    Chao-Wen Cheng, Wen-Fang Fang, Jiunn-Diann Lin, Appuwawadu Mestri Nipun Lakshitha de Silva
    PLOS ONE.2023; 18(11): e0289345.     CrossRef
  • Management of Graves’ hyperthyroidism: present and future
    Luigi Bartalena, Eliana Piantanida, Daniela Gallo, Silvia Ippolito, Maria Laura Tanda
    Expert Review of Endocrinology & Metabolism.2022; 17(2): 153.     CrossRef
  • The Prediction Model Using Thyroid-stimulating Immunoglobulin Bioassay For Relapse of Graves’ Disease
    Han-Sang Baek, Jaejun Lee, Chai-Ho Jeong, Jeongmin Lee, Jeonghoon Ha, Kwanhoon Jo, Min-Hee Kim, Jae Hyoung Cho, Moo Il Kang, Dong-Jun Lim
    Journal of the Endocrine Society.2022;[Epub]     CrossRef
  • Efficacy of Radioiodine Therapy in Patients With Primary Hyperthyroidism: An Institutional Review From Pakistan
    Asim Munir Alvi, Umal Azmat, Waqas Shafiq, Abdul Hannan Ali Rasheed, Ahmed Imran Siddiqi, Sardar Khan, Sara Ashfaq, Hira Irfan , Humayun Bashir, Muhammad Abu Bakar, Kashif Asghar
    Cureus.2022;[Epub]     CrossRef
  • Clinical Outcomes of Repeated Radioactive Iodine Therapy for Graves’ Disease
    Min Joo Kim, Sun Wook Cho, Ye An Kim, Hoon Sung Choi, Young Joo Park, Do Joon Park, Bo Youn Cho
    Endocrinology and Metabolism.2022; 37(3): 524.     CrossRef
  • Endocrine Surgery and Pediatic Surgery Partnership Reduces Complication Rate of Pediatric Thyroidectomy
    Ali Sayan, Mehmet Üstün, Mehmet Mert, Cem Karaali, Gökhan Köylüoğlu
    Journal of Dr Behcet Uz Children s Hospital.2022; 12(2): 164.     CrossRef
  • Thyroid-related adverse events induced by immune checkpoint inhibitors
    Alexandra Chera, Andreea Lucia Stancu, Octavian Bucur
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • A case of Hashimoto's thyroiditis following Graves' disease
    Ibtissem Oueslati, Salma Salhi, Meriem Yazidi, Fatma Chaker, Melika Chihaoui
    Clinical Case Reports.2022;[Epub]     CrossRef
  • Changes in the T and B lymphocyte subset profiles upon treatment of patients with Graves’ disease with radioactive iodine
    A. A. Savchenko, M. A. Dudina, S. A. Dogadin, A. G. Borisov, I. V. Kudryavtsev, D. V. Fomina, V. D. Belenyuk
    Medical Immunology (Russia).2022; 24(5): 1007.     CrossRef
  • A survey of the young person’s experience of Graves’ disease and its management
    Laura Claire Lane, Judith Rankin, Tim Cheetham
    Clinical Endocrinology.2021; 94(2): 330.     CrossRef
  • Serum T3 Level and Duration of Minimum Maintenance Dose Therapy Predict Relapse in Methimazole-Treated Graves Disease
    Yotsapon Thewjitcharoen, Krittadhee Karndumri, Waralee Chatchomchuan, Sriurai Porramatikul, Sirinate Krittiyawong, Ekgaluck Wanothayaroj, Siriwan Butadej, Soontaree Nakasatien, Rajata Rajatanavin, Thep Himathongkam
    Journal of the Endocrine Society.2021;[Epub]     CrossRef
  • Dosimetry-guided radioiodine therapy of hyperthyroidism: long-term experience and implications for guidelines
    Thomas Leitha, Manuela Schartel, Ingrid Hurtl, Rudolf Bednar, Franz König, Karl Mayrhofer, Flavia Pietschmann
    Nuclear Medicine Communications.2021; 42(2): 150.     CrossRef
  • Practice patterns and outcomes in the management of Thai patients with Graves’ disease
    Yotsapon Thewjitcharoen, Krittadhee Karndumri, Waralee Chatchomchuan, Sriurai Porramatikul, Sirinate Krittiyawong, Ekgaluck Wanathayanoroj, Nampetch Lekpittaya, Worawit Kittipoom, Tawee Anuntakulnatee, Somboon Vongterapak, Siriwan Butadej, Soontaree Nakas
    Thyroid Research.2021;[Epub]     CrossRef
  • Un case report letterario di tireotossicosi in La coscienza di Zeno di Italo Svevo
    Francesco Trimarchi, Luigi Bartalena, Stefano Arieti, Roberto Toni
    L'Endocrinologo.2021; 22(2): 149.     CrossRef
  • Medical treatment of thyrotoxicosis
    Lorenzo SCAPPATICCIO, Giuseppe BELLASTELLA, Maria I. MAIORINO, Luca GIOVANELLA, Katherine ESPOSITO
    The Quarterly Journal of Nuclear Medicine and Molecular Imaging.2021;[Epub]     CrossRef
  • Hiccups as a Rare Presentation of Thyrotoxicosis Triaged by an Epidural Steroid Injection
    Omar Al-Radideh, Iyad Farouji, Theodore DaCosta, Hossam Abed, Nicholas Baranestky
    Cureus.2021;[Epub]     CrossRef
  • Long-term antithyroid drug therapy
    David S. Cooper
    Current Opinion in Endocrinology, Diabetes & Obesity.2021; 28(5): 510.     CrossRef
  • The Continuum of Thyroid Disorders Related to Immune Checkpoint Inhibitors: Still Many Pending Queries
    Maria V. Deligiorgi, Sofia Sagredou, Lampros Vakkas, Dimitrios T. Trafalis
    Cancers.2021; 13(21): 5277.     CrossRef
  • Recurrence of Graves’ Disease: What Genetics of HLA and PTPN22 Can Tell Us
    Daniela Vejrazkova, Josef Vcelak, Eliska Vaclavikova, Marketa Vankova, Katerina Zajickova, Jana Vrbikova, Michaela Duskova, Petra Pacesova, Zdenek Novak, Bela Bendlova
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Most Patients with Graves’ Disease Treated with Antithyroid Drugs Eventually Require Additional Therapies
    Mary H. Samuels
    Clinical Thyroidology.2020; 32(1): 9.     CrossRef
  • Patterns of Use, Efficacy, and Safety of Treatment Options for Patients with Graves' Disease: A Nationwide Population-Based Study
    Juan P. Brito, Stephanie Payne, Naykky Singh Ospina, Rene Rodriguez-Gutierrez, Spyridoula Maraka, Lindsey R. Sangaralingham, Nicole M. Iñiguez-Ariza, Victor M. Montori, Marius N. Stan
    Thyroid.2020; 30(3): 357.     CrossRef
  • Long-Term Treatment of Hyperthyroidism with Antithyroid Drugs: 35 Years of Personal Clinical Experience
    Fereidoun Azizi
    Thyroid.2020; 30(10): 1451.     CrossRef
  • Predictive factors for early hypothyroidism following the radioactive iodine therapy in Graves’ disease patients
    Rui-Ting Hu, De-Shan Liu, Bin Li
    BMC Endocrine Disorders.2020;[Epub]     CrossRef
  • The Concept of Cure in Thyroid Diseases
    Fereidoun Azizi
    International Journal of Endocrinology and Metabolism.2020;[Epub]     CrossRef
  • Der Biomarker TSH bei Schilddrüsenautonomien
    K. Passek, N. Zulauf, E. Wanke, G. M. Oremek
    Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie.2020; 70(4): 177.     CrossRef
  • Management of Graves’ Hyperthyroidism: More Than a Century of Progression
    Hengameh Abdi, Atieh Amouzegar
    International Journal of Endocrinology and Metabolism.2020;[Epub]     CrossRef
  • Corticosteroid Pulse Therapy for Graves' Ophthalmopathy Reduces the Relapse Rate of Graves' Hyperthyroidism
    Rosario Le Moli, Pasqualino Malandrino, Marco Russo, Fabrizio Lo Giudice, Francesco Frasca, Antonino Belfiore, Riccardo Vigneri
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Prediction of Relapse After Antithyroid Drugs Withdrawal: A Narrative Review
    Pei-Wen Wang
    International Journal of Endocrinology and Metabolism.2020;[Epub]     CrossRef
  • Radioiodine-131 therapy (RIT) in benign thyroid diseases: Personalized prescription based on objectives with optional use of pharmacological modulators
    J. Clerc
    Médecine Nucléaire.2020; 44(4): 250.     CrossRef
  • Predicting the Risk of Graves Disease Relapse: Commentary on “Thyroid Peroxidase Antibody Positivity is Associated with Relapse-Free Survival Following Antithyroid Drug Treatment for Graves Disease”
    D. Gallo, M.L. Tanda, E. Piantanida
    Endocrine Practice.2020; 26(9): 1039.     CrossRef
  • Integrating Five Feature Types Extracted From Ultrasonograms to Improve the Prediction of Thyroid Papillary Carcinoma
    Renxiang Zhu, Zhongyu Wang, Yifan Zhang, Bingxin Yu, Mingran Qi, Xin Feng, Chenjun Wu, Yuxuan Cui, Lan Huang, Fan Li, Fengfeng Zhou
    IEEE Access.2019; 7: 101820.     CrossRef
  • Serum TSH Receptor Antibodies Fall Gradually and Only Rarely Switch Functional Activity in Treated Graves’ Disease
    Mary H. Samuels
    Clinical Thyroidology.2019; 31(8): 330.     CrossRef
  • Changes in Thyroid Peroxidase and Thyroglobulin Antibodies Might Be Associated with Graves' Disease Relapse after Antithyroid Drug Therapy
    Yun Mi Choi, Mi Kyung Kwak, Sang Mo Hong, Eun-Gyoung Hong
    Endocrinology and Metabolism.2019; 34(3): 268.     CrossRef
  • A transgenic mouse that spontaneously develops pathogenic TSH receptor antibodies will facilitate study of antigen-specific immunotherapy for human Graves’ disease
    Sandra M. McLachlan, Basil Rapoport
    Endocrine.2019; 66(2): 137.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism