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Zahra Bahadoran  (Bahadoran Z) 4 Articles
Obesity and Metabolism
Helicobacter pylori Stool Antigen Levels and Serological Biomarkers of Gastric Inflammation are Associated with Cardio-Metabolic Risk Factors in Type 2 Diabetic Patients
Zahra Bahadoran, Parvin Mirmiran, Maryam Zarif-yeaganeh, Homayoun Zojaji, Fereidoun Azizi
Endocrinol Metab. 2015;30(3):280-287.   Published online May 18, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.3.280
  • 3,132 View
  • 28 Download
  • 5 Web of Science
  • 4 Crossref
AbstractAbstract PDFPubReader   
Background

Helicobacter pylori infection and subsequent gastric inflammation have been proposed as risk factors for the development of insulin resistance and cardiovascular disease. In this study we assessed the possible association of H. pylori bacterial load, and serum biomarker of gastric inflammation with cardiometabolic risk factors in diabetic patients.

Methods

In this cross-sectional study, 84 H. pylori-infected type 2 diabetic patients were assessed for anthropometrics, biochemical and clinical measurements. Pearson correlation test, linear, and logarithmic regression curve estimation models were used to assess the association of H. pylori stool antigen (HpSAg) levels, and pepsinogen I (PGI) to pepsinogen II (PGII) ratio with fasting serum glucose, insulin, serum lipid and lipoprotein parameters, malondialdehyde, high-sensitive C-reactive protein (hs-CRP), systolic and diastolic blood pressure, body weight, waist circumference and lipid accumulation product (LAP) index.

Results

The mean age of participants was 54±10 years, and 44% were men. Mean HpSAg levels and PGI/PGII ratio were 0.24±0.23 µg/mL and 9.9±9.0, respectively. Higher HpSAg as well as lower PGI/PGII was correlated with higher anthropometric measures and LAP. A significant negative correlation between PGI/PGII ratio and blood pressure (r=-0.21 and r=-0.22, systolic and diastolic, respectively, P<0.05), serum insulin (r=-0.17, P=0.05), and hs-CRP (r=-0.17, P=0.05) was observed. A significant linear association between PGI/PGII ratio with serum triglycerides (β=-0.24, P<0.05), serum high density lipoprotein cholesterol (HDL-C; β=0.43, P<0.01), and triglycerides/HDL-C ratio (β=-0.28, P<0.05) were observed.

Conclusion

Higher H. pylori bacterial load and lower PGI/PGII ratio was associated with higher levels of cardiometabolic risk factors in H. pylori infected type 2 diabetic patients.

Citations

Citations to this article as recorded by  
  • Both diet and Helicobacter pylori infection contribute to atherosclerosis in pre- and postmenopausal cynomolgus monkeys
    Traci L. Testerman, Cristina Semino-Mora, Jennifer A. Cann, Beidi Qiang, Edsel A. Peña, Hui Liu, Cara H. Olsen, Haiying Chen, Susan E. Appt, Jay R. Kaplan, Thomas C. Register, D. Scott Merrell, Andre Dubois, Xianwu Cheng
    PLOS ONE.2019; 14(9): e0222001.     CrossRef
  • Associations of Helicobacter pylori infection and peptic disease with diabetic mellitus: Results from a large population-based study
    Saeda Haj, Gabriel Chodick, Rotem Refaeli, Sophy Goren, Varda Shalev, Khitam Muhsen, David M. Ojcius
    PLOS ONE.2017; 12(8): e0183687.     CrossRef
  • Helicobacter Pylori Infection Is Associated with Dyslipidemia and Increased Levels of Oxidized LDL in Type-2 Diabetes Mellitus
    Mohamed Hasan Mukhtar, Wesam Ahmed Nasif, Abdullatif Taha Babakr
    Journal of Diabetes Mellitus.2016; 06(03): 185.     CrossRef
  • Update on prevention and treatment of Helicobacter pylori infection
    Zhao-Chun Chi
    World Chinese Journal of Digestology.2016; 24(16): 2454.     CrossRef
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Obesity and Metabolism
Sugar-Sweetened Beverage Consumption Is Associated with Metabolic Syndrome in Iranian Adults: Tehran Lipid and Glucose Study
Hanieh-Sadat Ejtahed, Zahra Bahadoran, Parvin Mirmiran, Fereidoun Azizi
Endocrinol Metab. 2015;30(3):334-342.   Published online May 18, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.3.334
  • 3,731 View
  • 32 Download
  • 22 Web of Science
  • 23 Crossref
AbstractAbstract PDFPubReader   
Background

Metabolic syndrome (MetS), a cluster of multiple metabolic abnormalities, is one of the major public health challenges worldwide. The current study was conducted to evaluate the association between sugar-sweetened beverage (SSB) consumption and MetS and its components in Iranian adults.

Methods

This cross-sectional study was conducted among 5,852 men and women, aged 19 to 70 years, who participated in the fourth phase (2009 to 2011) of the Tehran Lipid and Glucose Study. Demographics, anthropometrics, biochemical measurements, and blood pressure (BP) were assessed and MetS was defined by National Cholesterol Education Program Adult Treatment Panel III definition. Frequency and quantity of SSB intakes including carbonated drinks and synthetic fruit juices were collected using a validated semiquantitative food frequency questionnaire.

Results

Mean age of participants (43%, men) was 40.6±12.9 years. Significant positive associations between SSBs and waist circumference, triglyceride level, systolic and diastolic BP in the third and fourth quartile of SSBs were observed, after adjustment for all potential confounding variables. The odds of MetS in the third and fourth quartiles compared to the first quartile category of SSBs was 1.21 (95% confidence interval [CI], 1.01 to 1.45) and 1.30 (95% CI, 1.06 to 1.58), respectively (P for trend=0.03). The odds of MetS, abdominal obesity, low high density lipoprotein cholesterol and elevated BP had increasing trends across increasing of SSB consumption (P for trend <0.05).

Conclusion

Higher intake of SSBs was associated with the higher odds of MetS in adults. It is suggested that reducing consumption of SSBs could be a practical approach to prevent metabolic abnormalities.

Citations

Citations to this article as recorded by  
  • Association between Sugar-Sweetened Beverage Consumption and the Risk of the Metabolic Syndrome: A Systematic Review and Meta-Analysis
    Ainara Muñoz-Cabrejas, Pilar Guallar-Castillón, Martín Laclaustra, Helena Sandoval-Insausti, Belén Moreno-Franco
    Nutrients.2023; 15(2): 430.     CrossRef
  • Relationship between Coffee, Tea, and Carbonated Beverages and Cardiovascular Risk Factors
    Hye-Ji An, Yejin Kim, Young-Gyun Seo
    Nutrients.2023; 15(4): 934.     CrossRef
  • The Association between the Consumption of Sugar-Sweetened Beverages and Metabolic Syndrome Components in Young Rural Adults in South Africa
    Mohlago Ablonia Seloka, Moloko Matshipi, Peter Modupi Mphekgwana, Kotsedi Daniel Monyeki
    Applied Sciences.2022; 12(6): 3015.     CrossRef
  • A comparison between body mass index and waist circumference for identifying continuous metabolic syndrome risk score components in Iranian school-aged children using a structural equation modeling approach: the CASPIAN-V study
    Hanieh-Sadat Ejtahed, Zohreh Mahmoodi, Mostafa Qorbani, Pooneh Angoorani, Mohammad Esmaeil Motlagh, Shirin Hasani-Ranjbar, Hasan Ziaodini, Majzoubeh Taheri, Ramin Heshmat, Roya Kelishadi
    Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2021; 26(5): 1609.     CrossRef
  • Dietary Intake and Health Status of Elderly Patients With Type 2 Diabetes Mellitus: Cross-sectional Study Using a Mobile App in Primary Care
    Joane Diomara Coleone, Ericles Andrei Bellei, Mateus Klein Roman, Vanessa Ramos Kirsten, Ana Carolina Bertoletti De Marchi
    JMIR Formative Research.2021; 5(8): e27454.     CrossRef
  • Prevalence and incidence of metabolic syndrome in Iran: A systematic review and meta-analysis
    Azad Fatahi, Amin Doosti-Irani, Zahra Cheraghi
    International Journal of Preventive Medicine.2020; 11(1): 64.     CrossRef
  • Sugar-sweetened beverages consumption in relation to hypertension among Iranian university students: the MEPHASOUS study
    Masoume Mansouri, Farshad Sharifi, Hamid Yaghubi, Mehdi Varmaghani, Yousef Moghadas Tabrizi, Morteza Nasiri, Omid Sadeghi
    Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2020; 25(4): 973.     CrossRef
  • Sugary beverages are associated with cardiovascular risk factors in diabetic patients
    Razieh Anari, Reza Amani, Masoud Veissi
    Journal of Diabetes & Metabolic Disorders.2019; 18(1): 7.     CrossRef
  • Consumo de bebidas açucaradas e fatores associados em adultos
    Danielle Cristina Guimarães da Silva, Wellington Segheto, Fernanda Cristina da Silva Amaral, Nínive de Almeida Reis, Ghéssica Santana Silva Veloso, Milene Cristine Pessoa, Juliana Farias de Novaes, Giana Zarbato Longo
    Ciência & Saúde Coletiva.2019; 24(3): 899.     CrossRef
  • The amounts and contributions of total drinking fluids and water from food to total water intake of young adults in Baoding, China
    Jianfen Zhang, Na Zhang, Shuxin Liang, Yan Wang, Shuzhuo Liu, Shufang Liu, Songming Du, Hairong He, Yifan Xu, Hao Cai, Xiaohui Guo, Lixin Ma, Guansheng Ma
    European Journal of Nutrition.2019; 58(7): 2669.     CrossRef
  • The association of glycemic index and glycemic load with elevated blood pressure in Iranian women
    Seyedeh Forough Sajjadi, Alireza Milajerdi, Leila Azadbakht
    Journal of Cardiovascular and Thoracic Research.2019; 11(4): 272.     CrossRef
  • Utility of waist circumference‐to‐height ratio as a screening tool for generalized and central obesity among Iranian children and adolescents: The CASPIAN‐V study
    Hanieh‐Sadat Ejtahed, Roya Kelishadi, Mostafa Qorbani, Mohammad Esmaeil Motlagh, Shirin Hasani‐Ranjbar, Pooneh Angoorani, Shaghayegh Beshtar, Hasan Ziaodini, Majzoubeh Taheri, Ramin Heshmat
    Pediatric Diabetes.2019;[Epub]     CrossRef
  • Discriminatory ability of visceral adiposity index as an indicator for modeling cardio-metabolic risk factors in pediatric population: the CASPIAN-V study
    Hanieh-Sadat Ejtahed, Roya Kelishadi, Shirin Hasani-Ranjbar, Pooneh Angoorani, Mohammad Esmaeil Motlagh, Gita Shafiee, Hasan Ziaodini, Majzoubeh Taheri, Mostafa Qorbani, Ramin Heshmat
    Journal of Cardiovascular and Thoracic Research.2019; 11(4): 280.     CrossRef
  • The Association between Various Lifestyle Patterns and the Body Mass Index in Adolescents
    Irina-Bianca Kosovski, Dana-Valentina Ghiga, Monica Tarcea, Cristina Nicoleta Ciurea, Ana Ioana Savin, Anca Bacârea
    Acta Medica Marisiensis.2019; 65(3): 111.     CrossRef
  • Sugar-Sweetened Beverages Consumption Positively Associated with the Risks of Obesity and Hypertriglyceridemia Among Children Aged 7–18 Years in South China
    Baoting He, Weiqing Long, Xiuhong Li, Wenhan Yang, Yajun Chen, Yanna Zhu
    Journal of Atherosclerosis and Thrombosis.2018; 25(1): 81.     CrossRef
  • Nutrition and Cardio-Metabolic Risk Factors: 20 Years of the Tehran Lipid and Glucose Study Findings
    Firoozeh Hosseini-Esfahani, Somaye Hosseinipour, Golaleh Asghari, Zahra Bahadoran, Nazanin Moslehi, Mahdieh Golzarand, Hanieh Ejtahed, Parvin Mirmiran, Fereidoun Azizi
    International Journal of Endocrinology and Metabolism.2018;[Epub]     CrossRef
  • Are non-high–density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study
    Pooneh Angoorani, Majid Khademian, Hanieh-Sadat Ejtahed, Ramin Heshmat, Mohammad Esmaeil Motlagh, Mahya Vafaeenia, Gita Shafiee, Armita Mahdivi-Gorabi, Mostafa Qorbani, Roya Kelishadi
    Lipids in Health and Disease.2018;[Epub]     CrossRef
  • Sugar-sweetened beverages consumption is associated with abdominal obesity risk in diabetic patients
    Razieh Anari, Reza Amani, Masoud Veissi
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2017; 11: S675.     CrossRef
  • Prevalence of metabolic syndrome and health-related quality of life in war-related bilateral lower limb amputees
    Hanieh-Sadat Ejtahed, Mohammad-Reza Soroush, Shirin Hasani-Ranjbar, Pooneh Angoorani, Batool Mousavi, Mehdi Masumi, Farhad Edjtehadi, Mahmood Soveid
    Journal of Diabetes & Metabolic Disorders.2017;[Epub]     CrossRef
  • Soft drink intake and the risk of metabolic syndrome: A systematic review and meta-analysis
    Aditya Narain, Chun Shing Kwok, Mamas A. Mamas
    International Journal of Clinical Practice.2017; 71(2): e12927.     CrossRef
  • Long-term consumption of sugar-sweetened beverage during the growth period promotes social aggression in adult mice with proinflammatory responses in the brain
    Jung-Yun Choi, Mi-Na Park, Chong-Su Kim, Young-Kwan Lee, Eun Young Choi, Woo Young Chun, Dong-Mi Shin
    Scientific Reports.2017;[Epub]     CrossRef
  • Frequent Consumption of Sugar- and Artificially Sweetened Beverages and Natural and Bottled Fruit Juices Is Associated with an Increased Risk of Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Disease Risk
    Cíntia Ferreira-Pêgo, Nancy Babio, Maira Bes-Rastrollo, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó, Lluís Serra-Majem, Fernando Arós, Miguel Fiol, José Manuel Santos-Lozano, Carlos Muñoz-Bravo, Xavier Pintó, Miguel Ruiz-Canela, Jordi Sala
    The Journal of Nutrition.2016; 146(8): 1528.     CrossRef
  • The effect of interaction between Melanocortin-4 receptor polymorphism and dietary factors on the risk of metabolic syndrome
    Gelareh Koochakpoor, Maryam S. Daneshpour, Parvin Mirmiran, Seyed Ahmad Hosseini, Firoozeh Hosseini-Esfahani, Bahareh Sedaghatikhayat, Fereidoun Azizi
    Nutrition & Metabolism.2016;[Epub]     CrossRef
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Obesity and Metabolism
Associations between Dietary Acid-Base Load and Cardiometabolic Risk Factors in Adults: The Tehran Lipid and Glucose Study
Zahra Bahadoran, Parvin Mirmiran, Hadise Khosravi, Fereidoun Azizi
Endocrinol Metab. 2015;30(2):201-207.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.201
  • 3,327 View
  • 28 Download
  • 31 Web of Science
  • 34 Crossref
AbstractAbstract PDFPubReader   
Background

In this study we investigated the associations of dietary acid-base load, identified by potential renal acid load (PRAL) and protein to potassium (Pro:K) ratio, with cardiometabolic risk factors in Tehranian adults.

Methods

A cross-sectional study was conducted within the framework of the fourth phase of the Tehran Lipid and Glucose Study (2009 to 2011) on 5,620 men and women aged 19 to 70 years. Dietary data were collected by a trained dietitian using a validated, 147-food item, semi-quantitative food frequency questionnaire, and dietary PRAL and Pro:K ratio were calculated. Multiple linear regression models with adjustment for potential confounding variables were used to evaluate the associations of dietary acid-base load with anthropometric measures, blood pressure, serum triglycerides, high density lipoprotein cholesterol (HDL-C), serum creatinine, and fasting blood glucose.

Results

The mean±SD age of the participants was 39.8±12.8 years and 54% of participants were women. Mean±SD PRAL was -22.0±29.1; mean PRAL was -15.6 in men and -26.8 in women. Dietary PRAL was associated with weight (β=0.098, P<0.001), waist circumference (β=0.062, P<0.01), serum triglycerides (β=0.143, P<0.01), HDL-C (β=-0.11, P<0.01), diastolic blood pressure (β=0.062, P<0.01), and serum creatinine (β=0.142, P<0.001). Pro:K ratio was associated with weight (β=0.055, P<0.001), waist circumference (β=0.04, P<0.01), serum HDL-C (β=-0.06, P<0.01), serum triglycerides (β=0.03, P<0.05), diastolic blood pressure (β=0.026, P<0.05), and serum creatinine (β=0.07, P<0.01).

Conclusion

A more acidic dietary acid-base load may be a risk factor for the development of metabolic disorders.

Citations

Citations to this article as recorded by  
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    Nutrition, Metabolism and Cardiovascular Diseases.2024;[Epub]     CrossRef
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    Nursel Sahın, Ugur Gunsen
    Critical Reviews in Food Science and Nutrition.2023; 63(28): 9033.     CrossRef
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    Maximilian Andreas Storz
    Journal of Racial and Ethnic Health Disparities.2023; 10(6): 2851.     CrossRef
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    Lifestyle Genomics.2023; 16(1): 61.     CrossRef
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    Tülay OMMA, Fatmanur Hümeyra ZENGİN, Süheyla AYDOĞMUŞ, Cavit ÇULHA
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    Nurefşan KONYALIGİL, Betül ÇİÇEK, Tuba TEKİN, Meltem ÜNLÜSAVURAN SÖNMEZ
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    International Journal for Vitamin and Nutrition Research.2021; 91(3-4): 343.     CrossRef
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    Firoozeh Hosseini-Esfahani, Somaye Hosseinipour, Golaleh Asghari, Zahra Bahadoran, Nazanin Moslehi, Mahdieh Golzarand, Hanieh Ejtahed, Parvin Mirmiran, Fereidoun Azizi
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Close layer
Obesity and Metabolism
Lipid Accumulation Product Is Associated with Insulin Resistance, Lipid Peroxidation, and Systemic Inflammation in Type 2 Diabetic Patients
Parvin Mirmiran, Zahra Bahadoran, Fereidoun Azizi
Endocrinol Metab. 2014;29(4):443-449.   Published online December 29, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.4.443
  • 3,997 View
  • 41 Download
  • 42 Web of Science
  • 43 Crossref
AbstractAbstract PDFPubReader   
Background

Lipid accumulation product (LAP) is a novel biomarker of central lipid accumulation related to risk of diabetes and cardiovascular disease. In this study, we assessed the association of LAP with glucose homeostasis, lipid and lipid peroxidation, and subclinical systemic inflammation in diabetic patients.

Methods

Thirty-nine male and 47 female type 2 diabetic patients were assessed for anthropometrics and biochemical measurements. LAP was calculated as [waist circumference (cm)-65]×[triglycerides (mmol/L)] in men, and [waist circumference (cm)-58]×[triglycerides (mmol/L)] in women. Associations of LAP with fasting glucose, insulin, insulin resistance index, lipid and lipoprotein levels, malondialdehyde, and high-sensitive C-reactive protein (hs-CRP) were assessed.

Results

Mean age and LAP index were 53.6±9.6 and 51.9±31.2 years, respectively. After adjustments for age, sex and body mass index status, a significant positive correlation was observed between LAP index and fasting glucose (r=0.39, P<0.001), and homeostasis model assessment of insulin resistance (r=0.31, P<0.05). After additional adjustment for fasting glucose levels, antidiabetic and antilipidemic drugs, the LAP index was also correlated to total cholesterol (r=0.45, P<0.001), high density lipoprotein cholesterol (HDL-C) levels (r=-0.29, P<0.05), triglycerides to HDL-C ratio (r=0.89, P<0.001), malondialdehyde (r=0.65, P<0.001), and hs-CRP levels (r=0.27, P<0.05).

Conclusion

Higher central lipid accumulation in diabetic patients was related to higher insulin resistance, oxidative stress and systemic inflammation.

Citations

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