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Yung Hsu 1 Article
Clinical Study
Efficacy of Ethanol Ablation for Benign Thyroid Cysts and Predominantly Cystic Nodules: A Systematic Review and Meta-Analysis
Cheng-Chun Yang, Yung Hsu, Jyun-Yan Liou
Endocrinol Metab. 2021;36(1):81-95.   Published online February 24, 2021
DOI: https://doi.org/10.3803/EnM.2020.833
  • 6,180 View
  • 232 Download
  • 11 Web of Science
  • 15 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Ultrasound-guided minimally invasive procedures are widely used to treat thyroid diseases. The objective of this study was to assess the efficacy and safety of ethanol ablation (EA) in comparison with other non-surgical options in the treatment of benign thyroid cystic nodules.
Methods
We conducted a systematic search of studies on EA for thyroid cystic nodules, mainly in the Ovid-MEDLINE and Embase, Web of Science, and Cochrane databases. The standardized mean difference (SMD) of the volume reduction ratio (VRR) after EA versus other non-surgical treatments comprised the primary outcome, whereas the odds ratio (OR) of therapeutic success rates between the two groups comprised the secondary outcome.
Results
The meta-analysis included 19 studies (four randomized controlled trials and 15 non-randomized studies) with 1,514 participants. The cumulative VRR of EA was 83.908% (95% confidence interval [CI], 79.358% to 88.457%). EA had a significantly higher pooled VRR (SMD, 0.381; 95% CI, 0.028 to 0.734; P=0.030), but not a significantly higher pooled therapeutic success rate (OR, 0.867; 95% CI, 0.132 to 5.689; P=0.880), than other forms of non-surgical management including radiofrequency ablation (RFA), polidocanol sclerotherapy, and simple aspiration with or without saline flush. However, the VRR and therapeutic success rate were not significantly different between EA and RFA. Major complications were recorded only in six patients (0.53%) with self-limiting dysphonia.
Conclusion
The role of EA as the first-line treatment for benign thyroid cysts and predominantly cystic nodules is supported by its high effectiveness and good safety profile compared to other currently available non-surgical options.

Citations

Citations to this article as recorded by  
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    Dongbin Ahn, Ji Hye Kwak, Gil Joon Lee, Jin Ho Sohn
    Ultrasonography.2024; 43(1): 25.     CrossRef
  • The Comparison of Efficacy and Safety between Radiofrequency Ablation Alone and Ethanol Ablation Followed by Radiofrequency Ablation in the Treatment of Mixed Cystic and Solid Thyroid Nodule
    Min Gang Jo, Min Kyoung Lee, Jae Ho Shin, Min Guk Seo, So Lyung Jung
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    Journal of Clinical Medicine.2023; 12(17): 5445.     CrossRef
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    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2023; 66(9): 624.     CrossRef
  • Sclerotherapy with a Viscum Album Extract for the Two Patients with Cystic Thyroid Nodule
    Jae Ha Lee, Seung Won Lee, Ki Nam Park
    International Journal of Thyroidology.2023; 16(1): 139.     CrossRef
  • Percutaneous ethanol injection in thyroid nodular pathology and metastatic cervical adenopathies: A systematic review, meta-analysis and economic evaluation
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  • Safety and Efficacy of Ultrasound-Guided Radiofrequency Ablation for Benign Nonfunctional Thyroid Nodules in Children: A Retrospective Study of 62 Patients with Over Four Years of Follow-Up
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    Thyroid.2022; 32(5): 525.     CrossRef
  • Ethanol ablation for the treatment of benign thyroid nodules
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    The American Journal of Surgery.2022; 224(1): 408.     CrossRef
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  • Image-Guided Percutaneous Ablation for Primary and Metastatic Tumors
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  • Approach to FNA of Thyroid Gland Cysts
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