Endocrinology and Metabolism

Young Sun Hong (Hong YS)

10 Articles

Obesity and Metabolism
Neurocognitive Changes and Their Neural Correlates in Patients with Type 2 Diabetes Mellitus: Junghyun H Lee, Yera Choi, Chansoo Jun, Young Sun Hong, Han Byul Cho, Jieun E Kim, In Kyoon Lyoo; Endocrinol Metab. 2014;29(2):112-121. Published online June 26, 2014; DOI: https://doi.org/10.3803/EnM.2014.29.2.112

5,415 View
50 Download
34 Web of Science
31 Crossref

As the prevalence and life expectancy of type 2 diabetes mellitus (T2DM) continue to increase, the importance of effective detection and intervention for the complications of T2DM, especially neurocognitive complications including cognitive dysfunction and dementia, is receiving greater attention. T2DM is thought to influence cognitive function through an as yet unclear mechanism that involves multiple factors such as hyperglycemia, hypoglycemia, and vascular disease. Recent developments in neuroimaging methods have led to the identification of potential neural correlates of T2DM-related neurocognitive changes, which extend from structural to functional and metabolite alterations in the brain. The evidence indicates various changes in the T2DM brain, including global and regional atrophy, white matter hyperintensity, altered functional connectivity, and changes in neurometabolite levels. Continued neuroimaging research is expected to further elucidate the underpinnings of cognitive decline in T2DM and allow better diagnosis and treatment of the condition.

Citations

Citations to this article as recorded by

The level of serum retinol-binding protein is associated with diabetic mild cognitive impairment
Wenjie Zhang, Yuqi Yuan, Xiaoxia Cui, Shihong Chen, Xianghua Zhuang
Brain Research.2024; 1822: 148670. CrossRef
Research Progress on Lipocalin-2 in Diabetic Encephalopathy
Wenjie Zhang, Shihong Chen, Xianghua Zhuang
Neuroscience.2023; 515: 74. CrossRef
Voluntary Attention and Quality of Life in Patients With Type 1 and Type 2 Diabetes Mellitus: Differences in Changes Depending on Disease Type and Duration
N. E. Tadevosyan, A. S. Khachunts, M. Gohargani, A. A. Sahakyan, A. A. Tumanyan
Journal of Evolutionary Biochemistry and Physiology.2022; 58(2): 569. CrossRef
Modifiable risk factors for neurocognitive and psychosocial problems after Hodgkin lymphoma
AnnaLynn M. Williams, Sedigheh Mirzaei Salehabadi, Mengqi Xing, Nicholas S. Phillips, Matthew J. Ehrhardt, Rebecca Howell, Yutaka Yasui, Kevin C. Oeffinger, Todd Gibson, Eric J. Chow, Wendy Leisenring, Deokumar Srivastava, Melissa M. Hudson, Leslie L. Rob
Blood.2022; 139(20): 3073. CrossRef
Type 2 Diabetes Independent of Glycemic Control is Associated With Cognitive Impairments: Findings From NHANES
Rozmin Jiwani, Brittany Dennis, Alfonso L. Neri, Chandler Bess, Sara Espinoza, Jing Wang, Monica C. Serra
Clinical Nursing Research.2022; 31(7): 1225. CrossRef
Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis
Nathalie Marissal-Arvy, Marie-Pierre Moisan
Metabolism Open.2022; 15: 100202. CrossRef
Inside the diabetic brain: Insulin resistance and molecular mechanism associated with cognitive impairment and its possible therapeutic strategies
Bhaskar Jyoti Dutta, Shamsher Singh, Sanket Seksaria, Ghanshyam Das Gupta, Amrita Singh
Pharmacological Research.2022; 182: 106358. CrossRef
The role of LRP1 in Aβ efflux transport across the blood-brain barrier and cognitive dysfunction in diabetes mellitus
Xue P, Long Zz, Jiang Gg, Wang Lp, Bian Cm, Wang Yl, M.F. Chen, Li W
Neurochemistry International.2022; 160: 105417. CrossRef
Childhood Neurotoxicity and Brain Resilience to Adverse Events during Adulthood
AnnaLynn M. Williams, Yin Ting Cheung, Geehong Hyun, Wei Liu, Kirsten K. Ness, Matthew J. Ehrhardt, Daniel A. Mulrooney, Nickhill Bhakta, Pia Banerjee, Tara M. Brinkman, Daniel M. Green, Wassim Chemaitilly, I‐Chan Huang, Deokumar Srivastava, Melissa M. Hu
Annals of Neurology.2021; 89(3): 534. CrossRef
Metformin restores hippocampal neurogenesis and learning and memory via regulating gut microbiota in the obese mouse model
Xiaoyi Ma, Wenchang Xiao, Hao Li, Pei Pang, Feixiao Xue, Lu Wan, Lei Pei, Huanhuan Yan
Brain, Behavior, and Immunity.2021; 95: 68. CrossRef
Promoting Successful Cognitive Aging: A Ten-Year Update
Taylor J. Krivanek, Seth A. Gale, Brittany M. McFeeley, Casey M. Nicastri, Kirk R. Daffner
Journal of Alzheimer's Disease.2021; 81(3): 871. CrossRef
Association of Vitamin D Level and Nerve Conduction Study Parameters with Cognitive Function in Diabetic Neuropathy Patients
Aida Fithrie, Fasihah Irfani Fitri, Muhammad Reza Putra
Open Access Macedonian Journal of Medical Sciences.2021; 9(B): 72. CrossRef
Insulin resistance takes center stage: a new paradigm in the progression of bipolar disorder
Cynthia V. Calkin
Annals of Medicine.2019; 51(5-6): 281. CrossRef
Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial
Mary A. Byrn, William Adams, Sue Penckofer, Mary Ann Emanuele
Journal of Diabetes Research.2019; 2019: 1. CrossRef
Neurocognitive impairment in type 2 diabetes mellitus
Marianna Karvani, P. Simos, S. Stavrakaki, D. Kapoukranidou
Hormones.2019; 18(4): 523. CrossRef
Benefits of combination low-dose pioglitazone plus fish oil on aged type 2 diabetes mice
Yuzuru Iizuka, Hyounju Kim, Satoshi Hirako, Kanako Chiba, Masahiro Wada, Akiyo Matsumoto
Journal of Food and Drug Analysis.2018; 26(4): 1265. CrossRef
Association of ApoE Genetic Polymorphism and Type 2 Diabetes with Cognition in Non-Demented Aging Chinese Adults: A Community Based Cross-Sectional Study
Jie Zhen, Tong Lin, Xiaochen Huang, Huiqiang Zhang, Shengqi Dong, Yifan Wu, Linlin Song, Rong Xiao, Linhong Yuan
Aging and disease.2018; 9(3): 346. CrossRef
Chronic Health Conditions and Neurocognitive Function in Aging Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study
Yin Ting Cheung, Tara M Brinkman, Chenghong Li, Yasmin Mzayek, Deokumar Srivastava, Kirsten K Ness, Sunita K Patel, Rebecca M Howell, Kevin C Oeffinger, Leslie L Robison, Gregory T Armstrong, Kevin R Krull
JNCI: Journal of the National Cancer Institute.2018; 110(4): 411. CrossRef
Diabetes, Depression, and Cognition: a Recursive Cycle of Cognitive Dysfunction and Glycemic Dysregulation
Sheila Black, Kyle Kraemer, Avani Shah, Gaynell Simpson, Forrest Scogin, Annie Smith
Current Diabetes Reports.2018;[Epub] CrossRef
Hypoglycemia is associated with dementia in elderly patients with type 2 diabetes mellitus: An analysis based on the Korea National Diabetes Program Cohort
Sang Ouk Chin, Sang Youl Rhee, Suk Chon, Sei Hyun Baik, Yongsoo Park, Moon Suk Nam, Kwan Woo Lee, Ki Hong Chun, Jeong-taek Woo, Young Seol Kim
Diabetes Research and Clinical Practice.2016; 122: 54. CrossRef
Bipolar disorders, type 2 diabetes mellitus, and the brain
Tomas Hajek, Roger McIntyre, Martin Alda
Current Opinion in Psychiatry.2016; 29(1): 1. CrossRef
1,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin Therapy
Min Kyeong Kim, Hye Seung Jung, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Seong Yeon Kim
Endocrinology and Metabolism.2016; 31(2): 284. CrossRef
Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood
Seung-Hwan Lee, Janice M. Zabolotny, Hu Huang, Hyon Lee, Young-Bum Kim
Molecular Metabolism.2016; 5(8): 589. CrossRef
Toll-like receptor 2 and type 2 diabetes
Zahra Sepehri, Zohre Kiani, Ali Akbar Nasiri, Farhad Kohan
Cellular & Molecular Biology Letters.2016;[Epub] CrossRef
Long-term Variability in Glycemic Control Is Associated With White Matter Hyperintensities in APOE4 Genotype Carriers With Type 2 Diabetes
Abigail Livny, Ramit Ravona-Springer, Anthony Heymann, Rachel Priess, Tammar Kushnir, Galia Tsarfaty, Leeron Rabinov, Reut Moran, Hadass Hoffman, Itzik Cooper, Lior Greenbaum, Jeremy Silverman, Mary Sano, Sterling C. Johnson, Barbara B. Bendlin, Michal Sc
Diabetes Care.2016; 39(6): 1056. CrossRef
DIABETES MELLITUS Y SU ASOCIACIÓN CON DETERIORO COGNITIVO Y DEMENCIA
Gonzalo Muñoz A., Christina Degen, Johannes Schröder, Pablo Toro E.
Revista Médica Clínica Las Condes.2016; 27(2): 266. CrossRef
Blood electrolyte disturbances during severe hypoglycemia in Korean patients with type 2 diabetes
Mi Yeon Kang
The Korean Journal of Internal Medicine.2015; 30(5): 648. CrossRef
Whenever You Lose Connection, Take Intranasal Insulin?
Antje Gottschalk, Björn Ellger
Diabetes.2015; 64(3): 687. CrossRef
Spatial Patterns of Structural Brain Changes in Type 2 Diabetic Patients and Their Longitudinal Progression With Intensive Control of Blood Glucose
Guray Erus, Harsha Battapady, Tianhao Zhang, James Lovato, Michael E. Miller, Jeff D. Williamson, Lenore J. Launer, R. Nick Bryan, Christos Davatzikos
Diabetes Care.2015; 38(1): 97. CrossRef
Articles in 'Endocrinology and Metabolism' in 2014
Won-Young Lee
Endocrinology and Metabolism.2015; 30(1): 47. CrossRef
Cerebrolysin reverses hippocampal neural atrophy in a mice model of diabetes mellitus type 1
Lizzette Sanchez‐Vega, Ismael Juárez, Maria De Jesus Gomez‐Villalobos, Gonzalo Flores
Synapse.2015; 69(6): 326. CrossRef

Endocrine Disorders and Dyslipidemia.: Young Sun Hong; J Korean Endocr Soc. 2008;23(1):9-14. Published online February 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.1.9

1,925 View
32 Download
1 Crossref

Abstract PDF

No abstract available.

Citations

Citations to this article as recorded by

Comparison of Health Behaviors and Nutritional Status related to Dyslipidemia in Korean Middle-Aged Adults - From the Korean National Health and Nutrition Examination Surveys, 2007~2010 -
Myung-Gon Shin, Ki-Hong Yoon, Mi-Young Song
The Korean Journal of Food And Nutrition.2016; 29(5): 724. CrossRef

Phenotypic Variation of Polycystic Ovary Syndrome.: Gun Woo Pyun, Young Ju Choi, Hyejin Lee, Jee Young Oh, Young Sun Hong, Yeon Ah Sung, Hye Won Chung; J Korean Endocr Soc. 2007;22(5):326-331. Published online October 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.5.326

2,027 View
23 Download
4 Crossref

Abstract PDF

BACKGROUND
Polycystic ovary syndrome (PCOS) is a common disorder in premenopausal women, but there has been little agreement on its diagnostic criteria due to its uncertain pathogenesis and the heterogeneity of symptoms. This study was performed in order to assess the differences in clinical, metabolic, and hormonal characteristics of women in the PCOS subgroups defined by ESHRE criteria. METHODS: Subjects were divided into four PCOS subgroups based on ESHRE criteria. The grouping groupings included: 1) hyperandrogenism, oligomenorrhea, and polycystic ovary morphology (HA + OM + PCO); 2) hyperandrogenism and oligomenorrhea (HA + OM); 3) hyperandrogenism and polycystic ovary morphology (HA + PCO); and 4) oligomenorrhea and polycystic ovary morphology (OM + PCO). Reproductive hormones and metabolic profiles were measured. RESULTS: Of the total number of subjects, 60 (40%) fulfilled the criteria for HA + OM + PCO, 50 (33%) for HA + OM, 11 (7%) for HA + PCO, and 30 (20%) for OM + PCO. There were no significant differences in clinical or metabolic features among the groups, except for LH, total cholesterol, and HDL cholesterol. CONCLUSION: In this population defined by ESHRE criteria, 73% of the patients met the former NIH definition for PCOS. Different phenotypes of PCOS cases were clinically or biochemically similar. Whether these women have an increased risk of infertility or metabolic complications remains to be determine.

Citations

Citations to this article as recorded by

Epidemiology and Diagnostic Criteria of Polycystic Ovary Syndrome
Hyejin Lee, Yeon-Ah Sung
The Journal of Korean Diabetes.2015; 16(3): 189. CrossRef
Hyperandrogenism in Women: Polycystic Ovary Syndrome
Yeon-Ah Sung
Hanyang Medical Reviews.2012; 32(4): 197. CrossRef
Polycystic Ovary Syndrome in Korean Women: Clinical Characteristics and Diagnostic Criteria
Yeon-Ah Sung
Endocrinology and Metabolism.2011; 26(3): 203. CrossRef
Clinical Manifestation of Polycysticv Ovary Syndrome
Yu-Bae Ahn
Journal of Korean Endocrine Society.2007; 22(5): 323. CrossRef

Therapeutic Effects of Metformin and Rosiglitazone in Korean Women with Polycystic Ovary Syndrome.: Jee Young Oh, Eun Kyung Byun, Hwi Ra Park, Young Ju Choi, Hyo Jung Kim, Hye Jin Lee, Young Sun Hong, Yeon Ah Sung, Hye Won Chung; J Korean Endocr Soc. 2005;20(5):467-475. Published online October 1, 2005; DOI: https://doi.org/10.3803/jkes.2005.20.5.467

2,092 View
21 Download
1 Crossref

Abstract PDF

BACKGROUND
Insulin resistance is a central feature of polycystic ovary syndrome (PCOS), and hyperinsulinemia contributes to anovulation, oligo or amenorrhea, hyperandrogenism and infertility in women with PCOS. The use of insulin sensitizers, such as metformin or thiazolidinedione, in PCOS is becoming increasingly accepted. The purpose of our study was to evaluate the therapeutic effects of metformin and rosiglitazone on the metabolic and reproductive derangement, and find parameters predicting their therapeutic efficacy in Korean PCOS women. METHODS: Sixty-two women with PCOS were recruited. The baseline characteristics, including BMI, glucose tolerance test, lipid profiles, sex hormones and hyperinsulinemic euglycemic clamp test, were assessed. After the administration of the insulin sensitizer (metformin 1.5g/day or rosiglitazone 4mg/day) for 3 months, the insulin sensitivity was reassessed. A drug response was defined as menstrual restoration or pregnancy. RESULTS: Of the 62 women with PCOS, 36 gained restored regular menstruation, and a further 5 conceived (a drug response rate of 66.7%). There were no significant clinical differences between responders and nonresponders. Twelve weeks after taking the drugs, the insulin sensitivity was significantly improved (M-value 4.7+/-0.2 vs. 5.5+/-0.4mg/kg/min, P<0.05), and the free testosterone levels(72.5+/-39.9 vs. 45.8 +/-3.8pmol/L, P<0.05) were significantly decreased, without significant weight reduction. CONCLUSION: Metformin and rosiglitazone restored menstruation in 66.1% of women with PCOS. Hyperandrogenemia and insulin sensitivity were significantly improved with the use of the two drugs. However, metabolic or hormonal markers for predicting the drug response could not be found.

Citations

Citations to this article as recorded by

Diagnosis and Treatment of Polycystic Ovary Syndrome
Hyejin Lee, Yeon-ah Sung
Journal of Korean Endocrine Society.2007; 22(4): 252. CrossRef

The Prevalence of Polycystic Ovary Syndrome in College Students from Seoul.: Eun Kyung Byun, Hyo Jeong Kim, Jee Young Oh, Young Sun Hong, Yeon Ah Sung; J Korean Endocr Soc. 2005;20(2):120-126. Published online April 1, 2005; DOI: https://doi.org/10.3803/jkes.2005.20.2.120

2,265 View
46 Download
21 Crossref

Abstract PDF

BACKGROUND
Polycystic ovary syndrome(PCOS) is characterized by the presence of chronic anovulation and hyperandrogenism, The prevalence of PCOS in premenopausal women of about 5~ 10%. There may be significant ethnic and racial variations in the prevalence and clinical presentation of PCOS. The current study was undertaken to determine the prevalence of PCOS and to identify the clinical characteristics of PCOS in Korea. METHODS: From March 2003 to March 2004, medical students from Ewha Womans University were investigated for the prevalence of PCOS. The evaluation included a history and physical examination, a modified Ferriman-Gallwey hirsutism score and screening for hyperandrogenemia. PCOS was diagnosed by the presence of the following: 1) oligomenorrhea, 2) hyperandrogenemia and/or hirsutism(a modified Ferriman-Gallwey score> or =6), and 3) the exclusion of related disorders. Hyperandrogenemia was defined as a free testosterone level above the 95th percentile of that for normal cycling nonhirsute women. RESULTS: Out of 492 students, 386 replied to the questionnaire and 203 students(19~31 yr of age) participated in the physical examination and blood sampling. Eumenorrhea without hirsutism was present in 133 students(65.5%), oligomenorrhea was present in 39 students(19.2%), hyperandrogenism was present in 21 students(10.3%) and hirsutism was present in 3(1.5%) of the 203 women. The prevalence of PCOS was 4.9%(10 of 203 students), and only 2 of 10 women with PCOS were hirsute. The mean body mass index of students with PCOS was 22.7+/- 4.3kg/m2, and two women was obese. The plasma insulin levels during the 75g oral glucose tolerance test in women with PCOS was significantly higher when compared to the age and body mass index of the controls. CONCLUSION: The prevalence of PCOS was 4.9% in college students from Seoul. This rate is similar to those rates reported by other investigators in Greece(6.7%) and United States(4%). Obesity and hirsutism are not common in Korean women with PCOS. We are planning to survey a more diverse age groups to determine the prevalence of PCOS

Citations

Citations to this article as recorded by

The Association Between Obesity and Polycystic Ovary Syndrome: An Epidemiologic Study of Observational Data
Mina Amiri, Sana Hatoum, Dawnkimberly Hopkins, Richard P Buyalos, Uche Ezeh, Lauren A Pace, Fernando Bril, Ali Sheidaei, Ricardo Azziz
The Journal of Clinical Endocrinology & Metabolism.2024; 109(10): 2640. CrossRef
Ethnicity in polycystic ovary syndrome
D. Shah, S. Rasool
Climacteric.2023; 26(1): 15. CrossRef
Preventive Behavior Intentions for Polycystic Ovary Syndrome in Young Students
Deulle Min, In Sun Jang, Seungmi Park
Metabolic Syndrome and Related Disorders.2022;[Epub] CrossRef
Age-Adjusted Prevalence and Characteristics of Women with Polycystic Ovarian Syndrome in Korea: A Nationwide Population-Based Study (2010–2019)
Ju Hee Kim, Min Hyung Jung, Se Hwa Hong, Nalae Moon, Dae Ryong Kang
Yonsei Medical Journal.2022; 63(8): 794. CrossRef
Effects of Exposure Duration and Exposure Levels of Ambient Air Pollutants on the Risk of Polycystic Ovarian Syndrome: A 2015–2019 Korean Population-Based Cohort Study
Ju-Hee Kim, Se-Hwa Hong, Na-Lae Moon, Dae-Ryong Kang
Toxics.2022; 10(9): 542. CrossRef
Gamitaeeumjowee-tang for Weight Loss in Overweight and Obese Women with Polycystic Ovary Syndrome: A Retrospective Chart Review
Min-jeong Park, Eunjoo Kim, Ji-Myung Ok, Ka-Hye Choi, Young-Woo Lim
Journal of Korean Medicine for Obesity Research.2022; 22(2): 136. CrossRef
Prevalence of Gestational Diabetes Mellitus in Korea: A National Health Insurance Database Study
Bo Kyung Koo, Joon Ho Lee, Jimin Kim, Eun Jin Jang, Chang-Hoon Lee, Noel Christopher Barengo
PLOS ONE.2016; 11(4): e0153107. CrossRef
Ethnic differences: Is there an Asian phenotype for polycystic ovarian syndrome?
Zhongwei Huang, Eu-Leong Yong
Best Practice & Research Clinical Obstetrics & Gynaecology.2016; 37: 46. CrossRef
Oral Contraceptive Use, Micronutrient Deficiency, and Obesity among Premenopausal Females in Korea: The Necessity of Dietary Supplements and Food Intake Improvement
Boyoung Park, Jeongseon Kim, David O. Carpenter
PLOS ONE.2016; 11(6): e0158177. CrossRef
Metabolic effects of polycystic ovary syndrome in adolescents
Yejin Han, Hae Soon Kim, Hye-Jin Lee, Jee-Young Oh, Yeon-Ah Sung
Annals of Pediatric Endocrinology & Metabolism.2015; 20(3): 136. CrossRef
Epidemiology and Diagnostic Criteria of Polycystic Ovary Syndrome
Hyejin Lee, Yeon-Ah Sung
The Journal of Korean Diabetes.2015; 16(3): 189. CrossRef
Dietary intake, dietary habits, and depression in Korean women with polycystic ovary syndrome
Seung Hyun Kim, Hyesook Kim, Seung Hee Park, Ji Yun Hwang, Hey Won Chung, Namsoo Chang
Korean Journal of Nutrition.2012; 45(3): 229. CrossRef
Hyperandrogenism in Women: Polycystic Ovary Syndrome
Yeon-Ah Sung
Hanyang Medical Reviews.2012; 32(4): 197. CrossRef
Polymorphism T→C of gene CYP17 promoter and polycystic ovary syndrome risk: A meta-analysis
Ya Li, Fei Liu, Shan Luo, Han Hu, Xiao-Hong Li, Shang-Wei Li
Gene.2012; 495(1): 16. CrossRef
Polycystic Ovary Syndrome in Korean Women: Clinical Characteristics and Diagnostic Criteria
Yeon-Ah Sung
Endocrinology and Metabolism.2011; 26(3): 203. CrossRef
Pro12Ala and His447His polymorphisms of PPAR-γ are associated with polycystic ovary syndrome
Bon-Hee Gu, Kwang-Hyun Baek
Reproductive BioMedicine Online.2009; 18(5): 644. CrossRef
Association study between single nucleotide polymorphisms in the VEGF gene and polycystic ovary syndrome
Eung-Ji Lee, Bermseok Oh, Jong-Young Lee, Kuchan Kimm, Jung-Mi Park, Kwang-Hyun Baek
Fertility and Sterility.2008; 89(6): 1751. CrossRef
Androgen receptor gene CAG repeat polymorphism in women with polycystic ovary syndrome
Jin Ju Kim, Seon Ha Choung, Young Min Choi, Sang Ho Yoon, Seok Hyun Kim, Shin Yong Moon
Fertility and Sterility.2008; 90(6): 2318. CrossRef
A novel single nucleotide polymorphism of INSR gene for polycystic ovary syndrome
Eung-Ji Lee, Bermseok Oh, Jong-Young Lee, Kuchan Kimm, Sook-Hwan Lee, Kwang-Hyun Baek
Fertility and Sterility.2008; 89(5): 1213. CrossRef
Diagnosis and Treatment of Polycystic Ovary Syndrome
Hyejin Lee, Yeon-ah Sung
Journal of Korean Endocrine Society.2007; 22(4): 252. CrossRef
Single nucleotide polymorphism in exon 17 of the insulin receptor gene is not associated with polycystic ovary syndrome in a Korean population
Eung-Ji Lee, Kyong-Jai Yoo, So-Jeong Kim, Sook-Hwan Lee, Kwang Yul Cha, Kwang-Hyun Baek
Fertility and Sterility.2006; 86(2): 380. CrossRef

Association of Serum Adiponectin Levels with Insulin Resistance in Women with Polycystic Ovary Syndrome.: Young Sun Hong, Jee Young Oh, Eun Kyung Byun, Yeon Ah Sung; J Korean Endocr Soc. 2004;19(4):369-378. Published online August 1, 2004

1,166 View
17 Download

Abstract PDF: BACKGROUND
Polycystic ovary syndrome (PCOS) is known to be associated with obesity and insulin resistance. The exact mechanism of insulin resistance in PCOS is not completely understood, but there are several pieces of evidence suggesting humoral mediator involvement. Adiponectin, an adipocyte-secreted protein, could be a possible link between adiposity and insulin resistance. This study was performed to see whether the serum adiponectin levels are suppressed in woman with PCOS and if this is associated with the characteristic hormonal and metabolic features of PCOS. METHODS: 20 women with PCOS and 8 normal controls with regular cycles were recruited. The serum adiponectin levels were measured by RIA, and the fasting glucose to insulin ratio (GIR) used as an insulin sensitivity index. RESULTS: The patients with PCOS were classified as lean (BMI < 23 kg/m2, n=9) and obese groups (BMI 25 kg/m2, n=11) based on the WPRO criteria. The GIR was significantly lower in the obese compared to the control group. The adiponectin level was lower in women with PCOS than the controls, but without statistical significance. In 5 of the 20 patients, the GIR was higher than 0.30, which was the lowest limit in the controls, and the adiponectin level was significantly higher than in those patients with a lower GIR. The adiponectin level was significantly correlated with the BMI, subcutaneous and visceral fat areas, post challenge 2 hr glucose, fasting insulin, GIR and SHBG. After adjustment for BMI, adiponectin was significantly correlated with the GIR in all subjects, including the controls. CONCLUSION: The serum adiponectin level was associated with and related to adiposity in women with PCOS; however, adiponectin might be associated with insulin resistance independently from adiposity

Sex Hormone-Binding Globulin and Oxidative Stress in Korean Premenopausal Women.: Young Ju Choi, Jee Young Oh, Young Sun Hong, Yeon Ah Sung; J Korean Endocr Soc. 2004;19(1):48-57. Published online February 1, 2004

1,490 View
30 Download

Abstract PDF: BACKGROUND
Low levels of sex hormone-binding globulin(SHBG), an indirect index of androgenicity, are associated with insulin resistance and cardiovascular risk factors. The risk factors of the cardiovascular disease are known to be related to oxidative stress. In recent reports, sex hormones were associated with oxidative stress in women with polycystic ovarian syndrome(PCOS), which is characterized by increased androgenicity and insulin resistance. METHODS: To investigate the relationship between sex hormones and oxidative stress, we examined the association of malondialdehyde(MDA), total antioxidant status(TAS), oxidized low density lipoprotein cholesterol(ox-LDL), and SHBG in 46 Korean premenopausal women. RESULTS: 1. SHBG and MDA levels were not significantly different among the women with NGT and IGT. But, TAS was significantly lower(p=0.034) in the subjects with IGT than in the subjects with NGT. 2. The SHBG level was significantly lower(p=0.036) in obese women than in non-obese women. 3.The SHBG level was significantly inversely correlated with BMI(r=-0.394, p=0.007), post challenge glucose(r=-0.326, p=0.027), waist size(r=-0.323, p=0.029), waist-to-thigh ratio(WTR) (r=-0.308, p=0.037), fasting insulin level(r=-0.387, p=0.008), visceral fat area(VFA)(r=-0.339, p=0.021), and was significantly positively correlated with SI(r=0.397, p=0.008). 4. The SHBG level was significantly inversely correlated with levels of MDA(r=-0.357, p=0.015) and ox-LDL(r=-0.367, p=0.014). 5. In a multiple linear regression analysis, the SHBG level was a significant and independent factor for both MDA and ox-LDL. For TAS, the fasting insulin level and post challenge glucose were significant and independent factors. CONCLUSION: Increased androgenicity assessed by the decrease in serum SHBG levels is associated with the increase in MDA and ox-LDL. These results suggest that increased androgenicity in premenopausal women can contribute to the development of cardiovascular diseases via increased oxidative stress.

The Relationship between Dehydroepiandrosterone sulfate and Insulin Resistance Syndrome in Women.: Hyo Jeong Kim, Eun Soon Hong, Jee Young Oh, Young Sun Hong, Yeon Ah Sung; J Korean Endocr Soc. 2002;17(5):675-684. Published online October 1, 2002

1,343 View
23 Download

Abstract PDF: BACKGROUND
Dehydroepiandrosterone (DHEA) is an androgen precursor, and is known to be decreased by the aging process. DHEA has been known to have a protective effect on insulin resistance and cardiovascular disease in men, but remains controversial in women. The aim of this study was to elucidate the role of DHEA on insulin resistance, and the risk for cardiovascular disease, in women. METHODS: We analyzed the relationship between DHEA sulfate (DHEAS), known to have a longer half-life and less diurnal variation than DHEA, and insulin resistance syndrome (IRS) in 471 non-diabetic women from an urban community diabetes prevalence study. Serum DHEAS concentrations were measured using a commercially available radioimmunoassay kit. RESULTS: 1. The frequencies of obesity, impaired glucose tolerance, hypertension and dyslipidemia were 25.3, 8.5, 21.9 and 6.2%, respectively, and the frequency of IRS was 16.5%. 2. DHEAS was significantly inversely correlated with age (r=-0.47, p<0.001), systolic blood pressure (r=-0.18, p<0.001), diastolic blood pressure (r=-0.10, p<0.05), fasting serum glucose (r=-0.10, p<0.05), postchallenge 2 hour glucose (r=-0.12, p<0.01) and triglycerides (r=-0.16, p<0.01). 3. As serum DHEAS concentrations, by quartiles, were decreased, the age-adjusted frequency of hypertension was significantly increased (p<0.05). 4. A Multiple linear regression analysis revealed that DHEAS was significantly associated with age (p<0.0001) and BMI (p<0.05). 5. A Logistic regression analysis showed that DHEAS was not associated with IRS after adjustment for age. CONCLUSION: DHEAS is inversely associated with age. DHEAS has no harmful effect, and may even have a protective role, on insulin resistance syndrome. Prospective examinations of DHEAS and insulin resistance syndrome in women are needed to confirm the mechanism for the association between DHEAS and the development of cardiovascular disease.

Relationship of Dehydroepiandrosterone Sulfate, Sex Hormone Binding Globulin and Carotid Atherosclerosis in Women.: Young Sun Hong, Yeon Ah Sung, Nan Ho Kyung, Jee Young Oh, Hye Young Choi; J Korean Endocr Soc. 1998;13(2):205-215. Published online January 1, 2001

1,330 View
17 Download

Abstract PDF: BACKGROUND
Cardiovascular disease is the major cause of morbidity and mortality. It is well known that androgen and sex hormone-binding globulin(SHBG) in women were associated with risk factors for cardiovascular disease such as obesity, central fat accumulation and atherogenic lipid profile. High resolution B-mode ultrasonography can visualize directly both luminal and vessel wall characteristics, and ultrasonic measurement of carotid intima-medial thickness(IMT) can be used to investigate the atherosclerosis of coronary, cerebral and peripheral arteries. The aim of this study was to evaluate the relationship between the serum dehydroepiandrosterone sulfate(DHEA-S) and SHBG, and body fat distribution pattern, cardiovascular risk factor and carotid atherosclerosis in women. METHODS: Blood pressure, fasting serum glucose, insulin, lipid profile, SHBG and DHEA-S were measured. Body fat distribution pattern was assessed by waist to hip ratio, waist to thigh ratio and subscapular to triceps skin fold thickness ratio, faf mass measured by bioelectric impedance analyzer, subcutaneous fat area, visceral fat area, and visceral to subcutaneous fat area ratio(VSR) at the level of umbilicus using the computed tomography. The IMT of the carotid artery was measured by high resolution B mode ultrasound as a marker of atherosclerosis. RESULTS: 1) There was no significant difference of age-adjusted values of carotid IMT among subjects with NGT(0.426+/-0.09mm), IGT(0.46+/-10.09mm) and NIDDM(0.453+/-0.11mm). 2) In postrnenopausal women, carotid IMT was greater(0.484+/-0.11mm, p=0.05) than premenopausal women(0.426+/-0.08mm), but it was not significant after age adjustment. Serum SHBG and DHEA-S levels in postmenopausal women were significantly lower(p<0.05) than premenopausal women, but they were not significant after age adjustment. 3) Carotid IMT was significantly correlated with age(r=0.37, p<0.01), fasting serum glucose (r=0.32, p<0.01), total cholesterol(r= 0.25, p<0.05), LDL-cholesterol(r=0.26, p<0.05), visceral fat area(r=0.35, p<0.01) and VSR(r=0.31, p<0.05). 4) By the stepwise multiple regression analysis, carotid IMT was positively and significantly associated with age(p<0.01) and serum DHEA-S concentration(p<0.05) in dent of age, body mass index, waist to hip ratio, fasting serum glucose. CONCLUSION: Carotid IMT was associated with age and serum DHEA-S concentration in women without cardiovascular disease. Therefore, serum DHEA-S may be one of risk factors for cardiovascular disease in women. However, we could not conclude its cause-result relationship because of cross sectional nature of our study, and prospective study will be needed.

A Case of Pheochromocytoma associated with Ectopic ACTH Syndrome.: Young Sun Hong, Hee Jin Kim, Yeon Ah Sung, Nan Ho Kyung, Ho Jung Kim, Sung Sook Kim; J Korean Endocr Soc. 1997;12(1):99-104. Published online January 1, 2001

1,253 View
25 Download

Abstract PDF: The syndrome of ectopic production of ACTH by non-pituitary neoplasm occur with various types of tu#rnors. Pheochromocytoma is a rare, but one of the important causes of this syndrome. Recently we experienced a 36-year-old male patient with ACTH-producing pheochromocytoma. After left adrenalectomy, serum ACTH level retumed to the normal range. The patient became normotensive without antihypertensive agents and hyperglycemia resolved and insulin therapy was discontinued. Secretion of ACTH was confirmed by immunohistochemical stain.

Author index