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Young Hye Cho  (Cho YH) 1 Article
Obesity and Metabolism
Comparison of Serum Ferritin and Vitamin D in Association with the Severity of Nonalcoholic Fatty Liver Disease in Korean Adults
Dong Wook Jeong, Hye Won Lee, Young Hye Cho, Dong Won Yi, Sang Yeoup Lee, Seok Man Son, Yang Ho Kang
Endocrinol Metab. 2014;29(4):479-488.   Published online December 29, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.4.479
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  • 13 Web of Science
  • 13 Crossref
AbstractAbstract PDFPubReader   
Background

Increased serum ferritin and decreased vitamin D levels associated with nonalcoholic fatty liver disease (NAFLD). However, their association with the severity of NAFLD has not been fully evaluated. The aim of this study was to compare the association of serum ferritin and 25(OH)D3 levels with the severity of ultrasonographically detected NAFLD (US-NAFLD) and hepatic steatosis defined by fatty liver index (FLI) in Korean adults.

Methods

A cross-sectional analysis of clinical and anthropometric data, including serum ferritin and 25(OH)D3, from men (n=295) and women (n=263) who underwent a routine health check-up in 2012.

Results

In men, with an increase in the quartile of serum ferritin level, the incidences of subjects with metabolic syndrome (P=0.002), US-NAFLD (P=0.041), and FLI ≥60 (P=0.010) were significantly elevated. In women, the incidence of subjects with US-NAFLD was also significantly elevated with increases in the serum ferritin quartile (P=0.012). Regarding 25(OH)D3, no statistical differences were observed among the different quartiles in either gender. Serum ferritin level significantly increased as the severity of US-NAFLD increased (P<0.001); however, no significant differences in 25(OH)D3 level were observed in men. No significant differences in either serum ferritin or 25(OH)D3 level were observed among women with different levels of severity of US-NAFLD.

Conclusion

Increased serum ferritin level showed a closer association with severity of NAFLD compared with level of serum vitamin D, suggesting that serum ferritin level may be a better marker than vitamin D level for predicting the severity of US-NAFLD and hepatic steatosis in a clinical setting.

Citations

Citations to this article as recorded by  
  • Serum 25-hydroxyvitamin D levels and the risk of non-alcoholic fatty liver: A two-sample Mendelian randomization study
    Qi Sheng, Huanchen Shi, Shousheng Liu, Likun Zhuang, Zhenzhen Zhao, Yongning Xin
    Saudi Journal of Gastroenterology.2023; 29(1): 39.     CrossRef
  • 2019 Global NAFLD Prevalence: A Systematic Review and Meta-analysis
    Michael H. Le, Yee Hui Yeo, Xiaohe Li, Jie Li, Biyao Zou, Yuankai Wu, Qing Ye, Daniel Q. Huang, Changqing Zhao, Jie Zhang, Chenxi Liu, Na Chang, Feng Xing, Shiping Yan, Zi Hui Wan, Natasha Sook Yee Tang, Maeda Mayumi, Xinting Liu, Chuanli Liu, Fajuan Rui,
    Clinical Gastroenterology and Hepatology.2022; 20(12): 2809.     CrossRef
  • Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?
    Hatice Hamarat, Göknur Yorulmaz, Ayşe Ekim Aydemir, Emel Örge Gönüllü, Ahmet Musmul, Sinem Gürcü
    Turkish Journal of Osteoporosis.2022; 28(1): 26.     CrossRef
  • Associations between Abnormal Iron Metabolism and Elevated Alanine Aminotransferase in Adults
    Xin Su, Danping Zhang, Zhe Chen, Xu Han, Peichen Xia, Minhao Yin, Hong Zhu
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Ferritin as a key risk factor for nonalcoholic fatty liver disease in children with obesity
    Junfeng Zhang, Jiajia Cao, Hui Xu, Guanping Dong, Ke Huang, Wei Wu, Jingjing Ye, Junfen Fu
    Journal of Clinical Laboratory Analysis.2021;[Epub]     CrossRef
  • Serum ferritin level as a noninvasive marker for detection and staging of hepatocellular injury, liver fibrosis, and steatosis in children and adolescents with nonalcoholic fatty liver disease
    AhmedA Hassan, MohieeE.-D.A El-Aziz Awad, HananH Soliman, RedaA.F Usef, DinaS Ata
    Alexandria Journal of Pediatrics.2021; 34(3): 253.     CrossRef
  • Low vitamin D level was associated with metabolic syndrome and high leptin level in subjects with nonalcoholic fatty liver disease: a community-based study
    Li-Wei Chen, Cheng-Hung Chien, Sheng-Fong Kuo, Chia-Ying Yu, Chih-Lang Lin, Rong-Nan Chien
    BMC Gastroenterology.2019;[Epub]     CrossRef
  • Association between Vitamin D Levels and Nonalcoholic Fatty Liver Disease: Potential Confounding Variables
    Lucia Pacifico, John F. Osborn, Enea Bonci, Pasquale Pierimarchi, Claudio Chiesa
    Mini-Reviews in Medicinal Chemistry.2019; 19(4): 310.     CrossRef
  • The association between serum ferritin and 25-hydroxyvitamin D and metabolic syndrome in Korean women: the Korea National Health and Nutrition Examination Survey 2010–2012
    Hyun Yoon, Nan Young Bae, Mi Young Gi, Bu Yeon Park, Jeong Min Seong
    Journal of Clinical Biochemistry and Nutrition.2017; 61(1): 60.     CrossRef
  • Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults
    Jeong Min Seong, Yo Sang Yoon, Kyu Su Lee, Nan Young Bae, Mi Young Gi, Hyun Yoon, Andrzej T Slominski
    PLOS ONE.2017; 12(5): e0177722.     CrossRef
  • The Association of Serum Ferritin and Metabolic Syndrome and Metabolic Syndrome Score in Korean Adults
    Hyun Yoon, Jae Seong Go, Kang Uk Kim, Keon Woo Lee
    The Korean Journal of Clinical Laboratory Science.2016; 48(4): 287.     CrossRef
  • AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells
    Jinmi Lee, Seok-Woo Hong, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
    Molecular and Cellular Endocrinology.2015; 414: 148.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
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