Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > BROWSE ARTICLES > Author index
Search
Young A Kim  (Kim YA) 2 Articles
Endocrine Research
Macrophage Densities Correlated with CXC Chemokine Receptor 4 Expression and Related with Poor Survival in Anaplastic Thyroid Cancer
Dae In Kim, Eunyoung Kim, Young A Kim, Sun Wook Cho, Jung Ah Lim, Young Joo Park
Endocrinol Metab. 2016;31(3):469-475.   Published online August 2, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.469
  • 4,881 View
  • 52 Download
  • 23 Web of Science
  • 17 Crossref
AbstractAbstract PDFPubReader   
Background

Tumor associated macrophages (TAMs) and CXC chemokine receptor 4 (CXCR4) have emerged as potential biomarkers in various human cancers. The aims of this study were to investigate the clinical characteristics of anaplastic thyroid cancer (ATC) patients according to the TAM numbers in the tumor tissue, and to evaluate the associations between CXCR4 expressions and macrophage densities in ATC tumor microenvironment.

Methods

Total 14 ATC samples from thyroid tissue microarray were used. Immunohistochemical staining was performed using anti-CD163 and anti-CXCR4 antibodies. According to the immunoreactivity of CD163, all subjects were divided into two groups: low-CD163 (n=8) and high-CD163 (n=6) groups.

Results

The mean diagnostic age was 65±7 years and the median tumor size was 4.3 cm, ranging 2.5 to 15 cm. Clinicopathological characteristics were not significantly different between low-CD163 and high-CD163 groups, while age of diagnosis was younger in high-CD163 group than that of low-CD163 group with marginal significance (56.9±5.5 years vs. 67.5±6.8 years, P=0.09). However, overall survival was significantly reduced in high-CD163 group (5.5 months [range, 1 to 10]) compared with low-CD163 groups (8.8 months [range, 6 to 121); log-rank test, P=0.0443). Moreover, high-CD163 group showed strong CXCR4 expressions in both cancer and stromal compartments, while low-CD163 group showed relatively weak, stromal-dominant CXCR4 expressions. Additionally, CD163 and CXCR4 expressions showed a strong positive correlation (γ2=0.432, P=0.013).

Conclusion

Increased number of TAMs showed poor overall survival in ATC, suggesting TAMs are potentially a prognostic biomarker for ATC. CXCR4 expression was significantly correlated with CD163-positive TAM densities, which suggest the possible role of CXCR4 in TAM recruitments.

Citations

Citations to this article as recorded by  
  • Emerging therapeutic options for follicular-derived thyroid cancer in the era of immunotherapy
    Naimah Turner, Sarah Hamidi, Rim Ouni, Rene Rico, Ying C. Henderson, Maria Puche, Sayan Alekseev, Jocelynn G. Colunga-Minutti, Mark E. Zafereo, Stephen Y. Lai, Sang T. Kim, Maria E. Cabanillas, Roza Nurieva
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • IL2RA+VSIG4+ tumor-associated macrophage is a key subpopulation of the immunosuppressive microenvironment in anaplastic thyroid cancer
    Zongfu Pan, Lisha Bao, Xixuan Lu, Xiaoping Hu, Lu Li, Jinming Chen, Tiefeng Jin, Yiwen Zhang, Zhuo Tan, Ping Huang, Minghua Ge
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(1): 166591.     CrossRef
  • Crosstalk between Thyroid Carcinoma and Tumor-Correlated Immune Cells in the Tumor Microenvironment
    Mingyuan Song, Qi Liu, Wei Sun, Hao Zhang
    Cancers.2023; 15(10): 2863.     CrossRef
  • Modeling the tumor microenvironment of anaplastic thyroid cancer: an orthotopic tumor model in C57BL/6 mice
    Zhen Xu, Hyo Shik Shin, Yoo Hyung Kim, Seong Yun Ha, Jae-Kyung Won, Su-jin Kim, Young Joo Park, Sareh Parangi, Sun Wook Cho, Kyu Eun Lee
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Tumor-associated macrophages as a potential therapeutic target in thyroid cancers
    Liya Zhu, Xiu Juan Li, Prakash Gangadaran, Xiuli Jing, Byeong-Cheol Ahn
    Cancer Immunology, Immunotherapy.2023; 72(12): 3895.     CrossRef
  • Functional Phenotypes of Peritoneal Macrophages Upon AMD3100 Treatment During Colitis-Associated Tumorigenesis
    Shuai Wu, Weiwei Luo, Xing Wu, Zhaohua Shen, Xiaoyan Wang
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Integrated analysis of novel macrophage related signature in anaplastic thyroid cancer
    Yi Luo, Yi-Chen Yang, Ben Ma, Wei-Bo Xu, Tian Liao, Yu Wang
    Endocrine.2022; 78(3): 517.     CrossRef
  • Secreted Factors by Anaplastic Thyroid Cancer Cells Induce Tumor-Promoting M2-like Macrophage Polarization through a TIM3-Dependent Mechanism
    Cinthia Carolina Stempin, Romina Celeste Geysels, Sunmi Park, Luz Maria Palacios, Ximena Volpini, Claudia Cristina Motran, Eva Virginia Acosta Rodríguez, Juan Pablo Nicola, Sheue-yann Cheng, Claudia Gabriela Pellizas, Laura Fozzatti
    Cancers.2021; 13(19): 4821.     CrossRef
  • Immunotherapy for anaplastic thyroid carcinoma: the present and future
    Xixuan LU, Lisha BAO, Zongfu PAN, Minghua GE
    Journal of Zhejiang University (Medical Sciences).2021; 50(6): 675.     CrossRef
  • CXCL12/CXCR4 signal transduction in diseases and its molecular approaches in targeted-therapy
    Ashraf Mousavi
    Immunology Letters.2020; 217: 91.     CrossRef
  • Nobiletin Alone or in Combination with Cisplatin Decreases the Viability of Anaplastic Thyroid Cancer Cell Lines
    Diana P. Sousa, Marta Pojo, Ana T. Pinto, Valeriano Leite, Ana Teresa Serra, Branca M. Cavaco
    Nutrition and Cancer.2020; 72(2): 352.     CrossRef
  • The Thyroid Tumor Microenvironment: Potential Targets for Therapeutic Intervention and Prognostication
    Laura MacDonald, Jonathan Jenkins, Grace Purvis, Joshua Lee, Aime T. Franco
    Hormones and Cancer.2020; 11(5-6): 205.     CrossRef
  • Mouse Models as a Tool for Understanding Progression in BrafV600E-Driven Thyroid Cancers
    Iñigo Landa, Jeffrey A. Knauf
    Endocrinology and Metabolism.2019; 34(1): 11.     CrossRef
  • Low Lymphocyte-to-Monocyte Ratios Are Associated with Poor Overall Survival in Anaplastic Thyroid Carcinoma Patients
    Jonghwa Ahn, Eyun Song, Hye-Seon Oh, Dong Eun Song, Won Gu Kim, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Min Ji Jeon
    Thyroid.2019; 29(6): 824.     CrossRef
  • Targeting CD47 in Anaplastic Thyroid Carcinoma Enhances Tumor Phagocytosis by Macrophages and Is a Promising Therapeutic Strategy
    Christian M. Schürch, Matthias A. Roelli, Stefan Forster, Marie-Hélène Wasmer, Frido Brühl, Renaud S. Maire, Sergio Di Pancrazio, Marc-David Ruepp, Roland Giger, Aurel Perren, Anja M. Schmitt, Philippe Krebs, Roch-Philippe Charles, Matthias S. Dettmer
    Thyroid.2019; 29(7): 979.     CrossRef
  • Recent advances and emerging therapies in anaplastic thyroid carcinoma
    Maria E. Cabanillas, Mark Zafereo, Michelle D. Williams, Renata Ferrarotto, Ramona Dadu, Neil Gross, G. Brandon Gunn, Heath Skinner, Gilbert Cote, Horiana B. Grosu, Priyanka Iyer, Naifa L. Busaidy
    F1000Research.2018; 7: 87.     CrossRef
  • Pathological processes and therapeutic advances in radioiodide refractory thyroid cancer
    Marika H Tesselaar, Johannes W Smit, James Nagarajah, Romana T Netea-Maier, Theo S Plantinga
    Journal of Molecular Endocrinology.2017; 59(4): R141.     CrossRef
Close layer
A Case of Acute Suppurative Thyroiditis Caused by Pyriform Sinus Fistula with Thyrotoxicosis.
Kyung Won Kim, Young Joo Park, Tae Yong Kim, Min Kyung Moon, Sae Won Han, Cheon Jung Eun, Young A Kim, Tae Hoon Jin, Hee Soon Chung, Do Joon Park, Bo Youn Cho
J Korean Endocr Soc. 2004;19(1):69-75.   Published online February 1, 2004
  • 997 View
  • 22 Download
AbstractAbstract PDF
This is the first case report about acute suppurative thyroiditis with thyrotoxicosis and pyriform sinus in Korea. A female patient, who was previously healthy, visited our hospital for the treatment of common cold symptoms and neck pain which developed 2 weeks before the visit. The condition of the patient did not improve through the use of antipyretics and even worsened. The patient was admitted to the hospital and was diagnosed with acute suppurative thyroiditis. The culture result of the drained fluid revealed group D Streptococcus. The patients condition was improved after using antibiotics and drainage. After recovery from acute thyroiditis, esophagography was performed and the pyriform sinus was found to be obliterated by chemical cauterization. It is very important yet difficult to differentiate acute thyroiditis with thyrotoxicosis from subacute thyroiditis. In this study, we discussed the differential diagnosis between acute thyroiditis and subacute thyroiditis with a review of literature.
Close layer

Endocrinol Metab : Endocrinology and Metabolism