- Diabetes, Obesity and Metabolism
- Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal Fat
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Sun Ok Song, You-Cheol Hwang, Han Uk Ryu, Steven E. Kahn, Donna L. Leonetti, Wilfred Y. Fujimoto, Edward J. Boyko
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Endocrinol Metab. 2021;36(4):835-844. Published online August 27, 2021
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DOI: https://doi.org/10.3803/EnM.2021.1130
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 Abstract
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- Background
Both intra-abdominal fat (IAF) and high-density lipoprotein cholesterol (HDL-C) are known to be associated with cardiometabolic health. We evaluated whether the accumulation of computed tomography (CT)-measured IAF over 5 years was related to baseline HDL-C concentration in a prospective cohort study.
Methods
All participants were Japanese-Americans between the ages of 34 and 74 years. Plasma HDL-C concentration and CT measurements of IAF, abdominal subcutaneous fat (SCF), and thigh SCF cross-sectional areas were assessed at baseline and at 5-year follow-up visits.
Results
A total of 397 subjects without diabetes were included. The mean±standard deviation HDL-C concentration was 51.6±13.0 mg/dL in men and 66.0±17.0 mg/dL in women, and the IAF was 91.9±48.4 cm2 in men and 63.1±39.5 cm2 in women. The baseline plasma concentration of HDL-C was inversely associated with the change in IAF over 5 years using multivariable regression analysis with adjustment for age, sex, family history of diabetes, weight change over 5 years, and baseline measurements of body mass index, IAF, abdominal SCF, abdominal circumference, thigh SCF, and homeostatic model assessment for insulin resistance.
Conclusion
These results demonstrate that HDL-C concentration significantly predicts future accumulation of IAF over 5 years independent of age, sex, insulin sensitivity, and body composition in Japanese-American men and women without diabetes.
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Citations
Citations to this article as recorded by  - Visceral Fat Area and Subcutaneous Fat Area Increase in Hyperthyroidism Patients After Treatment—A Single-Group Repeated-Measures Trial
Mengnan Li, Xifeng Yang, Ru Li, Baofeng Wu, Jinxuan Hao, Yijie Qi, Tao Bai, Luyang Yang, Yi Zhang, Yunfeng Liu
Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 2165. CrossRef - Fenofibrate add-on to statin treatment is associated with low all-cause death and cardiovascular disease in the general population with high triglyceride levels
Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park
Metabolism.2022; 137: 155327. CrossRef - The associations between lipid profiles and visceral obesity among gastrointestinal cancer patients: a cross-sectional study
Bo Gao, Xiangrui Li, Wenqing Chen, Shu’an Wang, Jian He, Yu Liu, Chao Ding, Xiaotian Chen
Lipids in Health and Disease.2022;[Epub] CrossRef
- Obesity and Metabolism
- Sulfonylurea: Personalized Medicine for Type 2 Diabetes
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You-Cheol Hwang
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Endocrinol Metab. 2015;30(4):467-468. Published online December 31, 2015
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DOI: https://doi.org/10.3803/EnM.2015.30.4.467
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- Obesity and Metabolism
- Letter: The Association between Serum Endogenous Secretory Receptor for Advanced Glycation End Products and Vertebral Fractures in Type 2 Diabetes (Endocrinol Metab 2012;27:289-94, Cheol Ho Lee et al.)
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You-Cheol Hwang
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Endocrinol Metab. 2013;28(1):76-77. Published online March 25, 2013
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DOI: https://doi.org/10.3803/EnM.2013.28.1.76
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Citations
Citations to this article as recorded by - Actualización de las recomendaciones para la evaluación y tratamiento de la osteoporosis asociada a enfermedades endocrinas y nutricionales. Grupo de trabajo de osteoporosis y metabolismo mineral de la SEEN
Rebeca Reyes-García, Antonia García-Martín, Mariela Varsavsky, Pedro Rozas-Moreno, María Cortés-Berdonces, Inés Luque-Fernández, José Manuel Gómez Sáez, Alfonso Vidal Casariego, Manuel Romero Muñoz, Sonsoles Guadalix Iglesias, Diego Fernández García, Este
Endocrinología y Nutrición.2015; 62(5): e47. CrossRef
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