Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism


Author index

Page Path
Yoon Hee Cho  (Cho YH) 2 Articles
Endocrine Research
Danshen Extracts Prevents Obesity and Activates Mitochondrial Function in Brown Adipose Tissue
Yoon Hee Cho, Cheol Ryong Ku, Young-Suk Choi, Hyeon Jeong Lee, Eun Jig Lee
Endocrinol Metab. 2021;36(1):185-195.   Published online February 24, 2021
  • 4,197 View
  • 127 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDFPubReader   ePub   
Danshen has been widely used in oriental medicine to improve body function. The purpose of this study is to investigate the effect of water-soluble Danshen extract (DE) on weight loss and on activation proteins involved in mitochondrial biogenesis in brown adipose tissue (BAT) in obese mice.
BAT was isolated from 7-week-old male Sprague-Dawley rats, and expression of proteins related to mitochondrial biogenesis was confirmed in both brown preadipocytes and mature brown adipocytes treated with DE. For the in vivo study, low-density lipoprotein receptor knock out mice were divided into three groups and treated for 17 weeks with: standard diet; high fat diet (HFD); HFD+DE. Body weight was measured every week, and oral glucose tolerance test was performed after DE treatment in streptozotocin-induced diabetic mice. To observe the changes in markers related to thermogenesis and adipogenesis in the BAT, white adipose tissue (WAT) and liver of experimental animals, tissues were removed and immediately frozen in liquid nitrogen.
DE increased the expression of uncoupling protein 1 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha in brown preadipocytes, and also promoted the brown adipocyte differentiation and mitochondrial function in the mature brown adipocytes. Reactive oxygen species production in brown preadipocytes was increased depending on the concentration of DE. DE activates thermogenesis in BAT and normalizes increased body weight and adipogenesis in the liver due to HFD. Browning of WAT was increased in WAT of DE treatment group.
DE protects against obesity and activates mitochondrial function in BAT.


Citations to this article as recorded by  
  • Pharmacological Benefits and Underlying Mechanisms of Salvia miltiorrhiza against Molecular Pathology of Various Liver Diseases: A Review
    Cho Hyun Hwang, Eungyeong Jang, Jang-Hoon Lee
    The American Journal of Chinese Medicine.2023; 51(07): 1675.     CrossRef
Close layer
Endocrine Research
The Effects of High Fat Diet and Resveratrol on Mitochondrial Activity of Brown Adipocytes
Cheol Ryong Ku, Yoon Hee Cho, Zhen-Yu Hong, Ha Lee, Sue Ji Lee, Seung-soo Hong, Eun Jig Lee
Endocrinol Metab. 2016;31(2):328-335.   Published online April 8, 2016
  • 3,891 View
  • 49 Download
  • 25 Web of Science
  • 25 Crossref
AbstractAbstract PDFPubReader   

Resveratrol (RSV) is a polyphenolic phytoalexin that has many effects on metabolic diseases such as diabetes and obesity. Given the importance of brown adipose tissue (BAT) for energy expenditure, we investigated the effects of RSV on brown adipocytes.


For the in vitro study, interscapular BAT was isolated from 7-week-old male Sprague Dawley rats. For the in vivo study, 7-week-old male Otsuka Long Evans Tokushima Fatty (OLETF) rats were divided into four groups and treated for 27 weeks with: standard diet (SD); SD+RSV (10 mg/kg body weight, daily); high fat diet (HFD); HFD+RSV. RSV was provided via oral gavage once daily during the in vivo experiments.


RSV treatment of primary cultured brown preadipocytes promoted mitochondrial activity, along with over-expression of estrogen receptor α (ER-α). In OLETF rats, both HFD and RSV treatment increased the weight of BAT and the differentiation of BAT. However, only RSV increased the mitochondrial activity and ER-α expression of BAT in the HFD-fed group. Finally, RSV improved the insulin sensitivity of OLETF rats by increasing the mitochondrial activity of BAT, despite having no effects on white adipocytes and muscles in either diet group.


RSV could improve insulin resistance, which might be associated with mitochondrial activity of brown adipocyte. Further studies evaluating the activity of RSV for both the differentiation and mitochondrial activity of BAT could be helpful in investigating the effects of RSV on metabolic parameters.


Citations to this article as recorded by  
  • Natural Bioactive Compounds from Foods Inhibited Pigmentation Especially Potential Application of Fucoxanthin to Chloasma: a Mini-Review
    Yida Wang, Hang Qi
    Food Reviews International.2024; 40(1): 20.     CrossRef
  • Resveratrol combats chronic diseases through enhancing mitochondrial quality
    Weichu Tao, Hu Zhang, Xia Jiang, Ning Chen
    Food Science and Human Wellness.2024; 13(2): 597.     CrossRef
  • The Potential to Fight Obesity with Adipogenesis Modulating Compounds
    Jiaqi Zhao, Ailin Zhou, Wei Qi
    International Journal of Molecular Sciences.2022; 23(4): 2299.     CrossRef
  • Macrophage and Adipocyte Mitochondrial Dysfunction in Obesity-Induced Metabolic Diseases
    Liwen Wang, Jie Hu, Haiyan Zhou
    The World Journal of Men's Health.2021; 39(4): 606.     CrossRef
  • Precision Nutrition to Activate Thermogenesis as a Complementary Approach to Target Obesity and Associated-Metabolic-Disorders
    Marina Reguero, Marta Gómez de Cedrón, Sonia Wagner, Guillermo Reglero, José Carlos Quintela, Ana Ramírez de Molina
    Cancers.2021; 13(4): 866.     CrossRef
  • Natural Antioxidant Application on Fat Accumulation: Preclinical Evidence
    Proshanta Roy, Daniele Tomassoni, Enea Traini, Ilenia Martinelli, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Francesco Amenta, Seyed Khosrow Tayebati
    Antioxidants.2021; 10(6): 858.     CrossRef
  • Activation of Brown Adipose Tissue and Promotion of White Adipose Tissue Browning by Plant-based Dietary Components in Rodents: A Systematic Review
    Francisco J Osuna-Prieto, Borja Martinez-Tellez, Antonio Segura-Carretero, Jonatan R Ruiz
    Advances in Nutrition.2021; 12(6): 2147.     CrossRef
  • Role of Dietary Polyphenols in Adipose Tissue Browning: A Narrative Review
    Juan Salazar, Clímaco Cano, José L. Pérez, Ana Castro, María P. Díaz, Bermary Garrido, Rubén Carrasquero, Maricarmen Chacín, Manuel Velasco, Luis D´Marco, Joselyn Rojas-Quintero, Valmore Bermúdez
    Current Pharmaceutical Design.2020; 26(35): 4444.     CrossRef
  • Brown and Brite: The Fat Soldiers in the Anti-obesity Fight
    Shireesh Srivastava, Richard L. Veech
    Frontiers in Physiology.2019;[Epub]     CrossRef
  • Effect of resveratrol on adipokines and myokines involved in fat browning: Perspectives in healthy weight against obesity
    Oh Yoen Kim, Ji Yeon Chung, Juhyun Song
    Pharmacological Research.2019; 148: 104411.     CrossRef
  • Ginsenoside Rb2 Alleviates Obesity by Activation of Brown Fat and Induction of Browning of White Fat
    Yilian Hong, Yi Lin, Qiya Si, Lijuan Yang, Weisong Dong, Xuejiang Gu
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Programming of the Beige Phenotype in White Adipose Tissue of Adult Mice by Mild Resveratrol and Nicotinamide Riboside Supplementations in Early Postnatal Life
    Alba Serrano, Madhu Asnani-Kishnani, Ana María Rodríguez, Andreu Palou, Joan Ribot, María Luisa Bonet
    Molecular Nutrition & Food Research.2018;[Epub]     CrossRef
  • Effects of Polyphenols on Thermogenesis and Mitochondrial Biogenesis
    Tanila Wood dos Santos, Quélita Cristina Pereira, Lucimara Teixeira, Alessandra Gambero, Josep A. Villena, Marcelo Lima Ribeiro
    International Journal of Molecular Sciences.2018; 19(9): 2757.     CrossRef
  • Programming mediated by fatty acids affects uncoupling protein 1 (UCP-1) in brown adipose tissue
    Perla P. Argentato, Helena de Cássia César, Débora Estadella, Luciana P. Pisani
    British Journal of Nutrition.2018; 120(6): 619.     CrossRef
  • Effects of Genistein on Differentiation and Viability of Human Visceral Adipocytes
    Elena Grossini, Serena Farruggio, Giulia Raina, David Mary, Giacomo Deiro, Sergio Gentilli
    Nutrients.2018; 10(8): 978.     CrossRef
  • A comprehensive review of the health perspectives of resveratrol
    Abdur Rauf, Muhammad Imran, Hafiz Ansar Rasul Suleria, Bashir Ahmad, Dennis G. Peters, Mohammad S. Mubarak
    Food & Function.2017; 8(12): 4284.     CrossRef
  • The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus
    Yea Eun Kang, Sorim Choung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
    Endocrinology and Metabolism.2017; 32(3): 383.     CrossRef
  • A nutritional perspective on UCP1-dependent thermogenesis
    M. Luisa Bonet, Josep Mercader, Andreu Palou
    Biochimie.2017; 134: 99.     CrossRef
  • The Beneficial Effects of Quercetin, Curcumin, and Resveratrol in Obesity
    Yueshui Zhao, Bo Chen, Jing Shen, Lin Wan, Yinxin Zhu, Tao Yi, Zhangang Xiao
    Oxidative Medicine and Cellular Longevity.2017; 2017: 1.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
  • Antiobesity effects of resveratrol: which tissues are involved?
    Alfredo Fernández‐Quintela, Iñaki Milton‐Laskibar, Marcela González, Maria P. Portillo
    Annals of the New York Academy of Sciences.2017; 1403(1): 118.     CrossRef
  • Resveratrol attenuates triglyceride accumulation associated with upregulation of Sirt1 and lipoprotein lipase in 3T3-L1 adipocytes
    Haruki Imamura, Daiji Nagayama, Noriko Ishihara, Syo Tanaka, Rena Watanabe, Yasuhiro Watanabe, Yuta Sato, Takashi Yamaguchi, Noriko Ban, Hidetoshi Kawana, Masahiro Ohira, Kei Endo, Atsuhito Saiki, Kohji Shirai, Ichiro Tatsuno
    Molecular Genetics and Metabolism Reports.2017; 12: 44.     CrossRef
  • Resveratrol has dose-dependent effects on DNA fragmentation and mitochondrial activity of ovine secondary follicles cultured in vitro
    T.J.S. Macedo, V.R.P. Barros, A.P.O. Monte, B.B. Gouveia, M.É.S. Bezerra, A.Y.P. Cavalcante, R.S. Barberino, V.G. Menezes, M.H.T. Matos
    Zygote.2017; 25(4): 434.     CrossRef
  • Response: The Effects of High Fat Diet and Resveratrol on Mitochondrial Activity of Brown Adipocytes (Endocrinol Metab2016;31:328-35, Cheol Ryong Ku et al.)
    Cheol Ryong Ku, Eun Jig Lee
    Endocrinology and Metabolism.2016; 31(3): 482.     CrossRef
  • Letter: The Effects of High Fat Diet and Resveratrol on Mitochondrial Activity of Brown Adipocytes (Endocrinol Metab2016;31:328-35, Cheol Ryong Ku et al.)
    Ji-Young Cha
    Endocrinology and Metabolism.2016; 31(3): 480.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism