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Yoo Jin Jeong  (Jeong YJ) 1 Article
Development of Clinical Data Mart of HMG-CoA Reductase Inhibitor for Varied Clinical Research
Hun-Sung Kim, Hyunah Kim, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Sun Jung Baik, Seung-Hwan Lee, Jae Hyoung Cho, In Young Choi, Kun-Ho Yoon
Endocrinol Metab. 2017;32(1):90-98.   Published online February 28, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.90
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  • 12 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM
Background

The increasing use of electronic medical record (EMR) systems for documenting clinical medical data has led to EMR data being increasingly accessed for clinical trials. In this study, a database of patients who were prescribed statins for the first time was developed using EMR data. A clinical data mart (CDM) was developed for cohort study researchers.

Methods

Seoul St. Mary's Hospital implemented a clinical data warehouse (CDW) of data for ~2.8 million patients, 47 million prescription events, and laboratory results for 150 million cases. We developed a research database from a subset of the data on the basis of a study protocol. Data for patients who were prescribed a statin for the first time (between the period from January 1, 2009 to December 31, 2015), including personal data, laboratory data, diagnoses, and medications, were extracted.

Results

We extracted initial clinical data of statin from a CDW that was established to support clinical studies; the data was refined through a data quality management process. Data for 21,368 patients who were prescribed statins for the first time were extracted. We extracted data every 3 months for a period of 1 year. A total of 17 different statins were extracted. It was found that statins were first prescribed by the endocrinology department in most cases (69%, 14,865/21,368).

Conclusion

Study researchers can use our CDM for statins. Our EMR data for statins is useful for investigating the effectiveness of treatments and exploring new information on statins. Using EMR is advantageous for compiling an adequate study cohort in a short period.

Citations

Citations to this article as recorded by  
  • Long-term stroke and major bleeding risk in patients with non-valvular atrial fibrillation: A comparative analysis between non-vitamin K antagonist oral anticoagulants and warfarin using a clinical data warehouse
    Hancheol Lee, Jung Hwa Hong, Kwon-Duk Seo
    Frontiers in Neurology.2023;[Epub]     CrossRef
  • Carpal tunnel syndrome and tenosynovitis in women with breast cancer associated with hormone therapy
    Dong Jae Shin, Kyung Eun Nam, Dae Heon Song, Sun Im, Sun Jae Won, Yeo Hyung Kim, Seong Hoon Lim, Jong In Lee
    Medicine.2022; 101(5): e28786.     CrossRef
  • Data Pseudonymization in a Range That Does Not Affect Data Quality: Correlation with the Degree of Participation of Clinicians
    Soo-Yong Shin, Hun-Sung Kim
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Ten-year patient journey of stage III non-small cell lung cancer patients: A single-center, observational, retrospective study in Korea (Realtime autOmatically updated data warehOuse in healTh care; UNIVERSE-ROOT study)
    Hyun Ae Jung, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park
    Lung Cancer.2020; 146: 112.     CrossRef
  • Real-time autOmatically updated data warehOuse in healThcare (ROOT: An Innovative and Automated Data Collection System) (Preprint)
    Hyun Ae Jung, Oksoon Jeong, Dong Kyung Chang, Sehhoon Park, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park
    JMIR Medical Informatics.2020;[Epub]     CrossRef
  • Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea
    Seo Yeon Baik, Hyunah Kim, So Jung Yang, Tong Min Kim, Seung-Hwan Lee, Jae Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, Kun-Ho Yoon, Hun-Sung Kim
    Frontiers of Medicine.2019; 13(6): 713.     CrossRef
  • Proceed with Caution When Using Real World Data and Real World Evidence
    Hun-Sung Kim, Ju Han Kim
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Change in ALT levels after administration of HMG-CoA reductase inhibitors to subjects with pretreatment levels three times the upper normal limit in clinical practice
    Hyunah Kim, Hyeseon Lee, Tong Min Kim, So Jung Yang, Seo Yeon Baik, Seung-Hwan Lee, Jae-Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun-Ho Yoon, Hun-Sung Kim
    Cardiovascular Therapeutics.2018; 36(3): e12324.     CrossRef
  • Developing a multi-center clinical data mart of ACEI and ARB for real-world evidence (RWE)
    Hun-Sung Kim, Sue Hyun Lee, Tong Min Kim, Ju Han Kim
    Clinical Hypertension.2018;[Epub]     CrossRef
  • Comparative Analysis of the Suspected Heparin-Induced Thrombocytopenia Level in Korea
    Hun-Sung Kim, Hyunah Kim, Yoo Jin Jeong, Hyunyong Lee, Hyeon Woo Yim, Ji il Kim, In Sung Moon, Jang-Yong Kim
    Basic & Clinical Pharmacology & Toxicology.2017; 121(4): 360.     CrossRef
  • The differences in the incidence of diabetes mellitus and prediabetes according to the type of HMG-CoA reductase inhibitors prescribed in Korean patients
    Tong Min Kim, Hyunah Kim, Yoo Jin Jeong, Sun Jung Baik, So Jung Yang, Seung-Hwan Lee, Jae-Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun-Ho Yoon, Hun-Sung Kim
    Pharmacoepidemiology and Drug Safety.2017; 26(10): 1156.     CrossRef
  • Use of Moderate-Intensity Statins for Low-Density Lipoprotein Cholesterol Level above 190 mg/dL at Baseline in Koreans
    Hun-Sung Kim, Hyeseon Lee, Sue Hyun Lee, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Sun Jung Baik, Hyunah Kim, Seung-Hwan Lee, Jae Hyoung Cho, In-Young Choi, Kun-Ho Yoon, Ju Han Kim
    Basic & Clinical Pharmacology & Toxicology.2017; 121(4): 272.     CrossRef

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