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Yeong Gi Kim  (Kim YG) 1 Article
Transformation of Nonfunctioning Pancreatic Neuroendocrine Carcinoma Cells into Insulin Producing Cells after Treatment with Sunitinib
Jung Hun Ohn, Yeong Gi Kim, Se-Hoon Lee, Hye Seung Jung
Endocrinol Metab. 2013;28(2):149-152.   Published online June 18, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.2.149
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  • 13 Crossref
AbstractAbstract PDFPubReader   

We report a rare case of severe hypoglycemia after sunitinib treatment for pancreatic neuroendocrine carcinoma. We describe the initial clinical presentation, laboratory results, pathologic findings, and managment in a patient with a nonfunctioning pancreatic neuroendocrine carcinoma with liver metastases who developed life threatening hypoglycemia after 2 months of sunitinib therapy. A 46-year-old woman presented to the emergency department with loss of consciousness from hypoglycemia. Serum C-peptide and insulin levels at fasting state revealed that the hypoglycemia resulted from endogenous hyperinsulinemia. She had been diagnosed with nonfunctioning pancreatic neuroendocrine carcinoma based on a biopsy of metastatic cervical lymph node and was being treated with sunitinib, a small molecule tyrosine kinase inhibitor. Immunohistochemical stain of the metastatic liver mass demonstrated that the initially nonfunctioning neuroendocrine carcinoma cells had changed into insulin-producing cells after sunitinib therapy. Transarterial chemoembolization of the liver masses and systemic chemotherapy with streptozotocin/adriamycin relieved the hypoglycemia. A nonfunctioning pancreatic neuroendocrine carcinoma was transformed into an insulin-producing tumor after treatment with sunitinib, causing endogenous hyperinsulinemia and severe hypoglycemia.

Citations

Citations to this article as recorded by  
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    Todd Clover, Amrou Abdelkader, Guru Subramanian Guru Murthy
    Journal of Oncology Pharmacy Practice.2019; 25(6): 1516.     CrossRef
  • Hyperglycaemia Induced by Novel Anticancer Agents: An Undesirable Complication or a Potential Therapeutic Opportunity?
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  • Medical management of secretory syndromes related to gastroenteropancreatic neuroendocrine tumours
    Georgios K Dimitriadis, Martin O Weickert, Harpal S Randeva, Gregory Kaltsas, Ashley Grossman
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    Archives of Endocrinology and Metabolism.2015; 59(3): 270.     CrossRef
  • Pancreatic neuroendocrine tumors with transformation to insulinoma: an unusual presentation of a rare disease
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    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
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