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Won Seon Jeon  (Jeon WS) 6 Articles
Obesity and Metabolism
Comparison of Serum Adipocytokine Levels according to Metabolic Health and Obesity Status
Tae Hoon Lee, Won Seon Jeon, Ki Joong Han, Shin Yeoung Lee, Nam Hee Kim, Hyun Beom Chae, Choel Min Jang, Kyung Mo Yoo, Hae Jung Park, Min Kyung Lee, Se Eun Park, Hyung Geun Oh, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
Endocrinol Metab. 2015;30(2):185-194.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.185
  • 5,010 View
  • 34 Download
  • 16 Web of Science
  • 15 Crossref
AbstractAbstract PDFPubReader   
Background

Metabolic health is an emerging concept that is highly correlated with various metabolic complications, and adipocytokines have been causally linked to a wide range of metabolic diseases. Thus, this study compared serum adipocytokine levels according to metabolic health and obesity status.

Methods

Four hundred and fifty-six nondiabetic subjects (mean age, 40.5 years) were categorized into four groups according to metabolic health and obesity status: metabolically healthy nonobese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy nonobese (MUHNO), and metabolically unhealthy obese (MUHO). Being metabolically healthy was defined as the presence of fewer than two of the following five metabolic abnormalities: high blood pressure, high fasting blood glucose, high triglyceride, low high density lipoprotein cholesterol, and being in the highest decile of the homeostatic model assessment of insulin resistance index. Obesity status was assessed using body mass index (BMI), with obesity defined as a BMI higher than 25 kg/m2. Levels of serum interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor α (TNF-α), and adipocyte fatty acid binding protein (A-FABP) were also evaluated.

Results

Of the 456 subjects, 247 (54.2%) were in the MHNO group, 66 (14.5%) were in the MHO group, 66 (14.5%) were in the MUHNO group, and 77 (16.9%) were in the MUHO group. There were no significant differences in IL-6 or MCP-1 levels among the groups, but levels of TNF-α and A-FABP were significantly higher in the MUHNO group compared to the MHNO group.

Conclusion

High TNF-α and A-FABP levels are significantly associated with metabolically unhealthiness in nonobese Korean individuals.

Citations

Citations to this article as recorded by  
  • Differences in the levels of inflammatory markers between metabolically healthy obese and other obesity phenotypes in adults: A systematic review and meta-analysis
    Zhouli Su, Ljupcho Efremov, Rafael Mikolajczyk
    Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(2): 251.     CrossRef
  • Relationship between the thrombospondin-1/Toll-like receptor 4 (TSP1/TLR4) pathway and vitamin D levels in obese and normal weight subjects with different metabolic phenotypes
    Eman Y. Khairy, Azza Saad
    The Journal of Physiological Sciences.2023;[Epub]     CrossRef
  • Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?
    Lourdes Balcázar-Hernandez, Lourdes Basurto, Leticia Manuel-Apolinar, Sara Vega-García, Norma Basurto-Acevedo, Carlos Martínez-Murillo, Rosalinda Sánchez-Arenas
    Metabolites.2021; 11(11): 771.     CrossRef
  • Exploring Therapeutic Targets to Reverse or Prevent the Transition from Metabolically Healthy to Unhealthy Obesity
    Tenzin D. Dagpo, Christopher J. Nolan, Viviane Delghingaro-Augusto
    Cells.2020; 9(7): 1596.     CrossRef
  • Poor Vitamin D Status in Active Pulmonary Tuberculosis Patients and Its Correlation with Leptin and TNF-α
    Qiuzhen WANG, Aiguo MA, Tianlin GAO, Yufeng LIU, Lisheng REN, Lei HAN, Boyang WEI, Qian LIU, Chunjiang DONG, Yuze MU, Duo LI, Frans J KOK, Evert G SCHOUTEN
    Journal of Nutritional Science and Vitaminology.2019; 65(5): 390.     CrossRef
  • Metabolic Health—The Role of Adipo-Myokines
    Christine Graf, Nina Ferrari
    International Journal of Molecular Sciences.2019; 20(24): 6159.     CrossRef
  • Does the Metabolically Healthy Obese Phenotype Protect Adults with Class III Obesity from Biochemical Alterations Related to Bone Metabolism?
    Ligiane Marques Loureiro, Suzane Lessa, Rodrigo Mendes, Sílvia Pereira, Carlos José Saboya, Andrea Ramalho
    Nutrients.2019; 11(9): 2125.     CrossRef
  • Being Metabolically Healthy, the Most Responsible Factor for Vascular Health
    Eun-Jung Rhee
    Diabetes & Metabolism Journal.2018; 42(1): 19.     CrossRef
  • Association between Serum Dipeptidyl Peptidase-4 Concentration and Obesity-related Factors in Health Screen Examinees
    Ji Yeon Lee, Byoung Kuk Jang, Min Kyung Song, Hye Soon Kim, Mi-Kyung Kim
    Journal of Obesity & Metabolic Syndrome.2017; 26(3): 188.     CrossRef
  • Kofaktoren und Komorbiditäten bei Necrobiosis lipoidica – Analyse der deutschen DRG‐Daten von 2012
    Finja Jockenhöfer, Knut Kröger, Joachim Klode, Regina Renner, Cornelia Erfurt‐Berge, Joachim Dissemond
    JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2016; 14(3): 277.     CrossRef
  • The relationship between serum fatty-acid binding protein 4 level and lung function in Korean subjects with normal ventilatory function
    Hye-Jeong Park, Se Eun Park, Cheol-Young Park, Seong Yong Lim, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
    BMC Pulmonary Medicine.2016;[Epub]     CrossRef
  • Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012
    Finja Jockenhöfer, Knut Kröger, Joachim Klode, Regina Renner, Cornelia Erfurt‐Berge, Joachim Dissemond
    JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2016; 14(3): 277.     CrossRef
  • Response: Comparison of Serum Adipocytokine Levels according to Metabolic Health and Obesity Status (Endocrinol Metab2015;30:185-94, Tae Hoon Lee et al.)
    Eun-Jung Rhee
    Endocrinology and Metabolism.2015; 30(3): 416.     CrossRef
  • Letter: Comparison of Serum Adipocytokine Levels according to Metabolic Health and Obesity Status (Endocrinol Metab2015;30:185-94, Tae Hoon Lee et al.)
    Mikyung Kim
    Endocrinology and Metabolism.2015; 30(3): 414.     CrossRef
  • Adipokine Profiles and Metabolic Health
    Seung-Hwan Lee
    Endocrinology and Metabolism.2015; 30(2): 175.     CrossRef
Close layer
Obesity and Metabolism
Antiobesity Pharmacotherapy for Patients with Type 2 Diabetes: Focus on Long-Term Management
Won Seon Jeon, Cheol-Young Park
Endocrinol Metab. 2014;29(4):410-417.   Published online December 29, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.4.410
  • 3,901 View
  • 41 Download
  • 11 Web of Science
  • 14 Crossref
AbstractAbstract PDFPubReader   

Type 2 diabetes and obesity have a complex relationship; obesity is linked to insulin resistance, the precursor to type 2 diabetes. The management of obesity is an important method to delay onset of diabetes and improve the glycemic durability of antidiabetic agents. However, insulin and some of the oral hypoglycemic agents used to treat diabetes cause significant weight gain, and it is difficult for patients with diabetes to reduce and maintain their weight by life-style changes alone. Thus, antiobesity medications or bariatric surgery may be a necessary adjunct for certain obese patients with diabetes. In 2012, the U.S. Food and Drug Administration (FDA) approved lorcaserin and phentermine/topiramate extended-release for the management of chronic weight, and approval for naltrexone/bupropion sustained-release as an adjunct to exercise and reduced caloric intake followed in 2014. Liraglutide is pending FDA approval for antiobesity drug. Here we review the efficacy of approved and new promising drugs for the management of obesity.

Citations

Citations to this article as recorded by  
  • A new kind of diabetes medication approved by the FDA: is there hope for obesity?
    Danisha Dhirani, Ahmad Shahid, Hassan Mumtaz
    International Journal of Surgery.2023; 109(2): 81.     CrossRef
  • Current pharmacological approaches in obesity treatment
    Pelin TİRYAKİOĞLU, Hüseyin YILMAZ, İsmail DEMİR, İsmail YILMAZ
    DAHUDER Medical Journal.2023; 3(2): 32.     CrossRef
  • Estudio del potencial antidiabético y antiobesidad de las hojas de Neurolaena lobata (Asteraceae)
    Yohum S Lozada-Diaz, Oscar J Patiño-Ladino, Fabián H López-Vallejo, Kevin P Lévuok-Mena, Juliet A Prieto-Rodríguez
    Revista Productos Naturales.2022; 5(2): 70.     CrossRef
  • Indikationsstellung in der Adipositastherapie – Surgeons first? // Indications in obesity therapy - surgeons first?
    Maximilian von Heesen
    Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie.2022; 147(06): 525.     CrossRef
  • Anti-Obesity Drugs: Long-Term Efficacy and Safety: An Updated Review
    Young Jin Tak, Sang Yeoup Lee
    The World Journal of Men's Health.2021; 39(2): 208.     CrossRef
  • Long-Term Efficacy and Safety of Anti-Obesity Treatment: Where Do We Stand?
    Young Jin Tak, Sang Yeoup Lee
    Current Obesity Reports.2021; 10(1): 14.     CrossRef
  • Weight-centric pharmacological management of type 2 diabetes mellitus – An essential component of cardiovascular disease prevention
    Emir Muzurović, Siniša Dragnić, Sanja Medenica, Brigita Smolović, Predrag Bulajić, Dimitri P. Mikhailidis
    Journal of Diabetes and its Complications.2020; 34(8): 107619.     CrossRef
  • Diet-induced obese alters the expression and function of hepatic drug-metabolizing enzymes and transporters in rats
    Lei Zhang, Peipei Xu, Yi Cheng, Peili Wang, Xinrun Ma, Mingyao Liu, Xin Wang, Feng Xu
    Biochemical Pharmacology.2019; 164: 368.     CrossRef
  • Updates on obesity pharmacotherapy
    Amanda Velazquez, Caroline M. Apovian
    Annals of the New York Academy of Sciences.2018; 1411(1): 106.     CrossRef
  • Effects of Obex in Overweight and Obese Subjects With or Without Impaired Fasting Glucose: A Pilot Study
    Eduardo Cabrera-Rode, Janet Rodríguez, Aimee Álvarez, Ragmila Echevarría, Antonio Darwin Reyes, Ileana Cubas-Dueñas, Silvia Elena Turcios-Tristá, Oscar Díaz-Díaz
    Journal of Dietary Supplements.2017; 14(6): 626.     CrossRef
  • Obesity context of type 2 diabetes and medication perspectives
    Abha Pandit, Abhay Kumar Pandey
    Apollo Medicine.2016; 13(2): 91.     CrossRef
  • Fatty acid metabolism and the basis of brown adipose tissue function
    María Calderon-Dominguez, Joan F. Mir, Raquel Fucho, Minéia Weber, Dolors Serra, Laura Herrero
    Adipocyte.2016; 5(2): 98.     CrossRef
  • The Perioperative Implications of New Weight Loss Drugs
    Jessica A. Darnobid, Stephanie B. Jones
    Advances in Anesthesia.2016; 34(1): 1.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
Close layer
Obesity and Metabolism
Increased Risk of Diabetes Development in Subjects with the Hypertriglyceridemic Waist Phenotype: A 4-Year Longitudinal Study
Ki Joong Han, Shin Yeoung Lee, Nam Hee Kim, Hyun Beom Chae, Tae Hoon Lee, Choel Min Jang, Kyung Mo Yoo, Hae Jung Park, Min Kyung Lee, Won Seon Jeon, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
Endocrinol Metab. 2014;29(4):514-521.   Published online December 29, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.4.514
  • 4,854 View
  • 30 Download
  • 21 Web of Science
  • 21 Crossref
AbstractAbstract PDFPubReader   
Background

The hypertriglyceridemic waist (HTGW) phenotype is a simple and inexpensive screening parameter to identify people at increased risk of cardiovascular disease. We evaluated whether the HTGW phenotype predicts diabetes in urban Korean adults.

Methods

A total of 2,900 nondiabetic subjects (mean age 44.3 years), comprising 2,078 males (71.7%) and 822 females (28.3%) who underwent annual medical check-ups at our center between January 2005 and December 2009, were recruited. The subjects were divided into four groups according to baseline serum triglyceride (TG) level and waist circumference (WC): normal WC-normal TG (NWNT) level, normal WC-high TG level, enlarged WC-normal TG level, and enlarged WC-high TG (EWHT) level. High serum TG level was defined as ≥150 mg/dL and enlarged WC was defined as ≥90 cm for men and ≥85 cm for women. New cases of diabetes were determined according to questionnaires filled in by participants and the diagnostic criteria of the American Diabetes Association. Cox proportional hazards model analysis was used to assess the association of HTGW phenotype with the incidence of diabetes.

Results

A total of 101 (3.5%) new diabetes cases were diagnosed during the study period. The EWHT group had a higher incidence of diabetes (8.3%) compared with the NWNT group (2.2%). The adjusted hazard ratio for diabetes for subjects with the EWHT phenotype at baseline was 4.113 (95% confidence interval [CI], 2.397 to 7.059) after adjustment for age, and 2.429 (95% CI, 1.370 to 4.307) after adjustment for age, sex, total cholesterol, systolic blood pressure, and alcohol drinking history. It was attenuated by inclusion of baseline fasting glucose level in the model.

Conclusion

Subjects with the HTGW phenotype showed the highest risk of incident diabetes. This tool could be useful for identifying individuals at high risk of diabetes.

Citations

Citations to this article as recorded by  
  • Triglyceridemic Waist Phenotypes as Risk Factors for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
    Fiorella E. Zuzunaga-Montoya, Víctor Juan Vera-Ponce
    International Journal of Statistics in Medical Research.2024; 13: 19.     CrossRef
  • Association between hypertriglyceridemic-waist phenotype and circadian syndrome risk: a longitudinal cohort study
    Li-Kun Hu, Yu-Hong Liu, Kun Yang, Ning Chen, Lin-Lin Ma, Yu-Xiang Yan
    Hormones.2023; 22(3): 457.     CrossRef
  • Caracterización del fenotipo de cintura hipertrigliceridémica en pacientes con diabetes mellitus tipo 2 en España: un estudio epidemiológico
    I. Miñambres, J. Sánchez-Hernández, G. Cuixart, A. Sánchez-Pinto, J. Sarroca, A. Pérez
    Revista Clínica Española.2021; 221(10): 576.     CrossRef
  • Association of “hypertriglyceridemic waist” with increased 5-year risk of subclinical atherosclerosis in a multi-ethnic population: a prospective cohort study
    Peyman Namdarimoghaddam, Adeleke Fowokan, Karin H. Humphries, G. B. John Mancini, Scott Lear
    BMC Cardiovascular Disorders.2021;[Epub]     CrossRef
  • Characterization of the hypertriglyceridemic waist phenotype in patients with type 2 diabetes mellitus in Spain: an epidemiological study
    I. Miñambres, J. Sánchez-Hernandez, G. Cuixart, A. Sánchez-Pinto, J. Sarroca, A. Pérez
    Revista Clínica Española (English Edition).2021; 221(10): 576.     CrossRef
  • Association between Hypertriglyceridemic-Waist Phenotype and Risk of Type 2 Diabetes Mellitus in Middle-Aged and Older Chinese Population: A Longitudinal Cohort Study
    Dezhong Chen, Ziyun Liang, Huimin Sun, Ciyong Lu, Weiqing Chen, Harry H. X. Wang, Vivian Yawei Guo
    International Journal of Environmental Research and Public Health.2021; 18(18): 9618.     CrossRef
  • Metabolic Syndrome, and Particularly the Hypertriglyceridemic-Waist Phenotype, Increases Breast Cancer Risk, and Adiponectin Is a Potential Mechanism: A Case–Control Study in Chinese Women
    Yujuan Xiang, Wenzhong Zhou, Xuening Duan, Zhimin Fan, Shu Wang, Shuchen Liu, Liyuan Liu, Fei Wang, Lixiang Yu, Fei Zhou, Shuya Huang, Liang Li, Qiang Zhang, Qinye Fu, Zhongbing Ma, Dezong Gao, Shude Cui, Cuizhi Geng, Xuchen Cao, Zhenlin Yang, Xiang Wang,
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
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    Minrui Xu, Mingtao Huang, Deren Qiang, Jianxin Gu, Yong Li, Yingzi Pan, Xingjuan Yao, Wenchao Xu, Yuan Tao, Yihong Zhou, Hongxia Ma, Ulrike Rothe
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
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    Yong-Cheng Ren, Yu Liu, Xi-Zhuo Sun, Bing-Yuan Wang, Yi Liu, Hu Ni, Yang Zhao, Dechen Liu, Xuejiao Liu, Dongdong Zhang, Feiyan Liu, Cheng Cheng, Leilei Liu, Xu Chen, Qionggui Zhou, Ming Zhang, Dongsheng Hu
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    Physiological Research.2019; : 931.     CrossRef
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    Eun-Jung Rhee
    Diabetes & Metabolism Journal.2018; 42(1): 19.     CrossRef
  • Letter: Utility of the Visceral Adiposity Index and Hypertriglyceridemic Waist Phenotype for Predicting Incident Hypertension (Endocrinol Metab 2017;32:221-9, Mohsen Janghorbani et al.)
    Eun-Jung Rhee
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    Cardiorenal Medicine.2017; 7(4): 295.     CrossRef
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    Jing Zeng, Miao Liu, Lei Wu, Jianhua Wang, Shanshan Yang, Yiyan Wang, Yao Yao, Bin Jiang, Yao He
    International Journal of Environmental Research and Public Health.2016; 13(12): 1233.     CrossRef
  • Prevalence of hypertriglyceridemic waist and association with risk of type 2 diabetes mellitus: a meta‐analysis
    Yongcheng Ren, Xinping Luo, Chongjian Wang, Lei Yin, Chao Pang, Tianping Feng, Bingyuan Wang, Lu Zhang, Linlin Li, Xiangyu Yang, Hongyan Zhang, Jingzhi Zhao, Dongsheng Hu
    Diabetes/Metabolism Research and Reviews.2016; 32(4): 405.     CrossRef
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    Mohsen Janghorbani, Masoud Amini
    Journal of Diabetes Investigation.2016; 7(6): 860.     CrossRef
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    Diabetes.2015; 64(12): 4212.     CrossRef
  • Hypertriglyceridemic Waist – a Simple Clinical Tool to Detect Cardiometabolic Risk: Comparison With Harmonized Definition of Metabolic Syndrome
    H. VAVERKOVÁ, D. KARÁSEK, D. NOVOTNÝ, M. HALENKA, J. ORSÁG, L. SLAVÍK
    Physiological Research.2015; : S385.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
  • Changes in Metabolic Health Status Over Time and Risk of Developing Type 2 Diabetes
    Seung-Hwan Lee, Hae Kyung Yang, Hee-Sung Ha, Jin-Hee Lee, Hyuk-Sang Kwon, Yong-Moon Park, Hyeon-Woo Yim, Moo-Il Kang, Won-Chul Lee, Ho-Young Son, Kun-Ho Yoon
    Medicine.2015; 94(40): e1705.     CrossRef
Close layer
Age Is the Strongest Effector for the Relationship between Estimated Glomerular Filtration Rate and Coronary Artery Calcification in Apparently Healthy Korean Adults
Hyun Beom Chae, Shin Yeoung Lee, Nam Hee Kim, Ki Joong Han, Tae Hoon Lee, Choel Min Jang, Kyung Mo Yoo, Hae Jung Park, Min Kyung Lee, Won Seon Jeon, Se Eun Park, Heui-Soo Moon, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
Endocrinol Metab. 2014;29(3):312-319.   Published online September 25, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.3.312
  • 4,083 View
  • 33 Download
  • 6 Web of Science
  • 7 Crossref
AbstractAbstract PDFPubReader   
Background

Chronic kidney disease (CKD) is considered one of the most common risk factors for cardiovascular disease. Coronary artery calcification (CAC) is a potential mechanism that explains the association between renal function and cardiovascular mortality. We aimed to evaluate the association between renal function and CAC in apparently healthy Korean subjects.

Methods

A total of 23,617 participants in a health-screening program at Kangbuk Samsung Hospital were included in the study. Estimated glomerular filtration rate (eGFR) was assessed using the Cockcroft-Gault equation. Coronary artery calcium score (CACS) was measured via multidetector computed tomography. Subjects were divided into three groups according to the CKD Staging system with eGFR grade: stage 1, eGFR ≥90 mL/min/1.73 m2; stage 2, eGFR 60 to 89 mL/min/1.73 m2; and stage 3, eGFR 30 to 59 mL/min/1.73 m2.

Results

The mean age of the participants was 41.4 years and the mean eGFR was 103.6±21.7 mL/min/1.73 m2. Hypertension and diabetes were noted in 43.7% and 5.5% of the participants, respectively. eGFR showed a weakly negative but significant association with CACS in bivariate correlation analysis (r=-0.076, P<0.01). Mean CACS significantly increased from CKD stage 1 to 3. The proportion of subjects who had CAC significantly increased from CKD stage 1 to 3. Although the odds ratio for CAC significantly increased from stage 1 to 3 after adjustment for confounding factors, this significance was reversed when age was included in the model.

Conclusion

In early CKD, renal function negatively correlated with the degree of CAC in Korean subjects. Age was the strongest effector for this association.

Citations

Citations to this article as recorded by  
  • The Relationship of Fetuin-A with Coronary Calcification, Carotid Atherosclerosis, and Mortality Risk in Non-Dialysis Chronic Kidney Disease
    Osama Nady Mohamed, Mahmoud Ragab Mohamed Mohamed, Israa Gamal Hassan, Atef Farouk Alakkad, Ashraf Othman, Amr Setouhi, Ahmed S. Issa
    Journal of Lipid and Atherosclerosis.2024; 13(2): 194.     CrossRef
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    Yejin Kim, Jeonggyu Kang, Yoosoo Chang, Young Youl Hyun, Kyu-Beck Lee, Hocheol Shin, Sarah H Wild, Christopher D Byrne, Seungho Ryu
    Nephrology Dialysis Transplantation.2023; 38(6): 1439.     CrossRef
  • New Model for Predicting the Presence of Coronary Artery Calcification
    Samel Park, Min Hong, HwaMin Lee, Nam-jun Cho, Eun-Young Lee, Won-Young Lee, Eun-Jung Rhee, Hyo-Wook Gil
    Journal of Clinical Medicine.2021; 10(3): 457.     CrossRef
  • Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea
    Seo Yeon Baik, Hyunah Kim, So Jung Yang, Tong Min Kim, Seung-Hwan Lee, Jae Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, Kun-Ho Yoon, Hun-Sung Kim
    Frontiers of Medicine.2019; 13(6): 713.     CrossRef
  • Chronic kidney disease and coronary artery calcification in the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil)
    Cheng Suh‐Chiou, Rosa M. Moysés, Marcio S. Bittencourt, Isabela M. Bensenor, Paulo A. Lotufo
    Clinical Cardiology.2017; 40(12): 1309.     CrossRef
  • Eligibility for Statin Treatment in Korean Subjects with Reduced Renal Function: An Observational Study
    Byung Sub Moon, Jongho Kim, Ji Hyun Kim, Young Youl Hyun, Se Eun Park, Hyung-Geun Oh, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Kyu-Beck Lee, Hyang Kim, Sung-Woo Park, Eun-Jung Rhee
    Endocrinology and Metabolism.2016; 31(3): 402.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
Close layer
Obesity and Metabolism
Association of Serum Adipocyte-Specific Fatty Acid Binding Protein with Fatty Liver Index as a Predictive Indicator of Nonalcoholic Fatty Liver Disease
Won Seon Jeon, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
Endocrinol Metab. 2013;28(4):283-287.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.283
  • 3,655 View
  • 33 Download
  • 16 Crossref
AbstractAbstract PDFPubReader   
Background

Adipocyte-specific fatty acid-binding protein (A-FABP) is a cytoplasmic protein expressed in macrophages and adipocytes and it plays a role in insulin resistance and metabolic syndrome. Recently, the fatty liver index (FLI) was introduced as an indicator of nonalcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the relationship between baseline serum A-FABP levels and FLI after 4 years in apparently healthy subjects.

Methods

A total of 238 subjects without a past history of alcoholism or hepatitis were recruited from a medical check-up program. The NAFLD state was evaluated 4 years later in the same subjects using FLI. Fatty liver disease was diagnosed as diffusely increased echogenicity of the hepatic parenchyma compared to the kidneys, vascular blurring, and deep-echo attenuation. NAFLD was defined as subjects with fatty liver and no history of alcohol consumption (>20 g/day).

Results

Baseline serum A-FABP levels were significantly associated with FLI after adjustment for age and sex (P<0.001). The subjects with higher A-FABP levels had a higher mean FLI (P for trend=0.006). After adjusting for age and sex, serum A-FABP levels at baseline were shown to be significantly associated with FLI as a marker of development of NAFLD after 4 years (odds ratio, 2.68; 95% confidence interval, 1.24 to 5.80 for highest tertile vs. lowest tertile; P=0.012).

Conclusion

This study demonstrated that higher baseline serum A-FABP levels were associated with FLI as a predictive indicator of NAFLD after 4 years of follow-up in healthy Korean adults.

Citations

Citations to this article as recorded by  
  • Insulin Resistance, Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Clinical and Experimental Perspective
    Inha Jung, Dae-Jeong Koo, Won-Young Lee
    Diabetes & Metabolism Journal.2024; 48(3): 327.     CrossRef
  • FABP4 Expression in Subcutaneous Adipose Tissue Is Independently Associated with Circulating Triglycerides in Obesity
    Óscar Osorio-Conles, Ainitze Ibarzabal, José María Balibrea, Josep Vidal, Emilio Ortega, Ana de Hollanda
    Journal of Clinical Medicine.2023; 12(3): 1013.     CrossRef
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Obesity and Metabolism
The Relationship of Body Composition and Coronary Artery Calcification in Apparently Healthy Korean Adults
Jung-Hee Yu, Seo Hyoung Yim, Su Hyeon Yu, Ji Yong Lee, Jong Dae Kim, Mi Hae Seo, Won Seon Jeon, Se-Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
Endocrinol Metab. 2013;28(1):33-40.   Published online March 25, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.1.33
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AbstractAbstract PDFSupplementary MaterialPubReader   
Background

We investigated the association of coronary artery calcium score (CACS) with body composition and insulin resistance in apparently healthy Korean adults.

Methods

Nine hundred forty-five participants (mean age, 48.9 years; 628 men) in a medical check-up program were selected for analysis. Body composition was assessed by bioelectrical impedance analysis (BIA). Insulin resistance was evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). The CACS was assessed by multidetector computed tomography.

Results

One hundred forty-six subjects (15.4%) showed coronary artery calcification and 148 subjects (15.7%) had metabolic syndrome. CACS showed a significant positive correlation with age, fasting glucose level, waist circumference (WC), blood pressure, hemoglobin A1c, HOMA-IR, and waist-hip ratio (WHR) assessed by BIA. CACS had a negative correlation with high density lipoprotein cholesterol (HDL-C). Subjects with high CACS showed significantly higher mean WHRs and lower mean values for lean body mass compared with subjects without coronary artery calcification. In logistic regression analyses with coronary artery calcification as the dependent variable, the highest quartile of WHR showed a 3.125-fold increased odds ratio for coronary artery calcification compared with the lowest quartile after adjustment for confounding variables. When receiver operating characteristics analyses were performed with coronary artery calcification as the result variable, WHR showed the largest area under the curve (AUC) value among other variables except for age and WC in women (AUC=0.696 for WHR, 0.790 for age, and 0.719 for WC in women).

Conclusion

In our study population of apparently healthy Korean adults, WHR was the most significant predictor for coronary artery calcification among other confounding factors, suggesting that it may have implication as a marker for early atherosclerosis.

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